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Publisher: Smart Science and Technology LLC   (Total: 20 journals)   [Sort by number of followers]

Showing 1 - 20 of 20 Journals sorted alphabetically
Abdomen     Open Access  
Cancer Cell & Microenvironment     Open Access   (Followers: 9)
Cardiovascular Regenerative Medicine     Open Access  
Evidence-based Medicine & Public Health     Open Access   (Followers: 7)
Immunoendocrinology     Open Access   (Followers: 1)
Itch & Pain     Open Access   (Followers: 2)
J. of Advanced Nutrition and Human Metabolism     Open Access   (Followers: 14)
Macrophage     Open Access  
Molecular & Cellular Epilepsy     Open Access   (Followers: 2)
Musculoskeletal Regeneration     Open Access   (Followers: 3)
Neurotransmitter     Open Access  
Precision Medicine     Open Access   (Followers: 2)
Receptors & Clinical Investigation     Open Access   (Followers: 1)
RNA & Disease     Open Access   (Followers: 1)
Science Proceedings     Open Access   (Followers: 1)
Stem Cell and Translational Investigation     Open Access   (Followers: 2)
Stem Cell Epigenetics     Open Access   (Followers: 3)
Telomere and Telomerase     Open Access  
Therapeutic Targets for Neurological Diseases     Open Access   (Followers: 1)
Uterus & Ovary     Open Access  
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ISSN (Online) 2378-1351
Published by Smart Science and Technology LLC Homepage  [20 journals]
  • Nurse's role in the screening path of Colorectal Cancer

    • Authors: Emanuele Sinagra
      Abstract: The nurse has an important role in screening path of  colorectal cancer. It represents a point of reference for many patients who seek advice correct and accurate to solve many doubts and concerns that inevitably arise after receiving a letter of invitation to the prevention program. The nurse is involved in the emotional support at time of diagnosis of positivity of the fecal immunochemical test, in the information and support through treatment decision making, in the preparation for colonoscopy, and, finally, in the ongoing assessment and care during and after colonoscopy.
      PubDate: 2017-08-28
      DOI: 10.14800/abdomen.1586
      Issue No: Vol. 4 (2017)
  • Changes in the Microvasculature of Small Bowel Mesentery in Rats with
           Prehepatic Portal Hypertension: the Preliminary Study in vivo

    • Authors: Nikolay Olegovich Arefyev, Dmitry Victorovich Garbuzenko, Ilya Vladimirovich Emelyanov, Linar Rinatovich Khasanov, Lyubov’ Vladimirovna Mineeva
      Abstract: According to the literature, neoangiogenesis in the mesentery of the small intestine is the trigger of portosystemic collateral circulation in portal hypertension. However, the types of blood vessels involved in this process have not been established. The aim of this study was to determine which type of the mesenteric microvessels participates in angiogenesis in portal hypertension. Studies were performed in 12 adult outbred female rats weighing 250 ± 50 g which were divided into two groups: sham-operated (n = 5) and experimental (n = 7). The mesenteric microcirculation of rats in both groups was examined by intravital microscopy during the first laparotomy and relaparotomy on the 15th day of the experiment. In contrast to the sham-operated animals, prehepatic portal hypertension was induced in rats of the experimental group by partial portal vein ligation during the first operation. Portal pressure was measured in both groups at the time of the second operation. The portal pressure in rats of the experimental group was significantly higher than in sham-operated rats: 12,53 ± 1,26 mm Hg and 9,34 ± 0,14 mm Hg, respectively (p<0,01). There was a significant increase in the number of capillaries (p <0,05) and total vascular density (p <0,05) in rats of both groups by the 15th day of the experiment. At the same time, a greater increase in the capillary network was observed in rats of the experimental group (p <0,05), whereas no significant differences were found in the values of vascular density of the other types of blood vessels. Changes in the mesenteric microvasculature in portal hypertension lay in the increase in the values of vascular density, which occurred mostly at the expense of capillaries.
      PubDate: 2017-08-14
      DOI: 10.14800/abdomen.1580
      Issue No: Vol. 4 (2017)
  • Cardiac portion of the stomach: a deep region within the abdomen

    • Authors: kanji hirashima, Fengming Yue, Daihachiro Tomotsune, Katsunori Sasaki
      Abstract: The cardiac portion of the stomach is situated deeply in the upper abdomen and relatively well hidden. The topographic space around it is very narrow and complicated. These topographical features are produced by the liver, especially segments I, II, and III. An understanding of the relationships among compacted organs facilitates operative access by surgeons.
      PubDate: 2017-07-31
      DOI: 10.14800/abdomen.1550
      Issue No: Vol. 4 (2017)
  • The Role of Probiotics and Synbiotics in Preventing Postoperative Sepsis
           in Gastrointestinal Surgery

    • Authors: Christine SM Lau, Sudha Arumugam, Ronald S. Chamberlain
      Abstract: Sepsis is a potentially fatal condition, accounting for over 1 million hospitalizations annually in the United States, with mortality rates as high as 40%.  Patients undergoing gastrointestinal (GI) surgery are especially susceptible to sepsis, due to bacterial translocation secondary to surgical trauma and the use of antibiotics. Probiotics and synbiotics, which have been hypothesized to counteract disturbances in the intestinal flora and reduce pathogenic bacterial colonization, have been proposed for the prevention and treatment of a variety of GI conditions, including sepsis. Recent randomized control trials and meta-analyses evaluating the use of probiotic/symbiotic supplementation in elective surgical patients have demonstrated a significant reduction in the risk of developing postoperative sepsis in patients with the use of probiotic/synbiotics. Coupled with the prevention of numerous other GI symptoms, such as diarrhea, probiotics should be considered in all elective surgical GI patients.
      PubDate: 2016-12-05
      DOI: 10.14800/abdomen.1462
      Issue No: Vol. 3 (2016)
  • Phosphorylation-Mediated Interaction of Hepatitis C Virus NS5A and the
           Cellular YB-1 Controls HCV Propagation and the Early Stage of Viral RNA

    • Authors: Yan-Hwa Wu Lee, Wei-Ting Wang
      Abstract: About 130-150 million individuals worldwide are chronically infected by hepatitis C virus (HCV); HCV infection has become a leading cause of liver cirrhosis and hepatocellular carcinoma. The HCV life cycle relies on the cooperation of specific viral proteins and various cellular factors. The cellular protein Y-box binding protein 1 (YB-1) has recently been identified as a HCV host cofactor; however, its mechanism has not been fully characterized. The HCV nonstructural protein NS5A plays critical roles in almost every stage of HCV propagation, and has been proposed to control the switch between the defined stages of the HCV life cycle. Moreover, NS5A has recently emerged as a target for the development of novel anti-HCV drugs. Our studies have found that YB-1 not only interacts with NS5A, but also protects NS5A from degradation. Furthermore, both the NS5A/YB-1 interaction and the NS5A-stabilizing activity of YB-1 are dependent on the phosphorylation of YB-1 at serine 102 (S102). Interestingly, the YB-1 S102 site has previously been reported to be phosphorylated by Akt, which is in turn activated by HCV infection. Our study also reveals that DDX3, an YB-1-interacting partner, is another NS5A-binding protein, which plays a different role than YB-1 in HCV RNA replication and infectious virus production. Taken together, the elucidation of YB-1 participation in the HCV life cycle has led to a proposed mechanism of efficient virus propagation via coordination of the different stages of the viral life cycle through controlling stage-wise switches in the viral life cycle. Our finding also provides a novel niche for designing strategies for the development of new anti-HCV drugs by blocking specific virus-host interactions. 
      PubDate: 2016-03-22
      DOI: 10.14800/abdomen.1212
      Issue No: Vol. 3 (2016)
  • An unusual and unvoluntary hemostatic technique for an incidental
           postprocedural bleeding

    • Authors: marco giunta, cristina linea, dario raimondo, Emanuele Sinagra
      Abstract: N/A
      PubDate: 2015-01-28
      DOI: 10.14800/abdomen.513
      Issue No: Vol. 3 (2015)
  • Efficacy of pneumatic dilatation for the treatment of idiopatic achalasia:
           a single-center experience

    • Authors: Emanuele Sinagra, Dario Raimondo, luigi maria montalbano, cristina linea, marco giunta, georgios amvrosiadis, gaetano cristian morreale, marco ciofalo, aroldo gabriele rizzo, giovanni tomasello, attilio ignazio lo monte, gennaro d'amico
      Abstract: Pneumatic dilatation (PD) and Surgical Miotomy (SM) are presently the best treatments for untreated achalasia, with similar efficacy. There is no information on the relative efficacy of PD in younger compared to older patients. Aim of our study was to compare success rate and safety of PD in patients under fifty years old and in those over fifty years old affected by achalasia.Twenty consecutive symptomatic patients were treated in our Unit with graded PD under fluoroscopic view. Five male and 15 female with a median age of 47 years were treated. Twelve patients were less than fifty years old (group I) while 8 were older (group II). Median dysphagia questionnaire score was 14 and13 ingroup I and II respectively. Technical success was achieved in all patients. Seven patients were previously treated through other techniques. In group I all patients achieved a complete remission of symptoms with significant decrease of the dysphagia questionnaire score (3). In group II all patients achieved a complete remission of symptoms with significant decrease of the dysphagia questionnaire score (4.5) but 3 of them repeated the procedure. In boths groups the efficacy of the dilation was radiologically confirmed. Neither early nor late complication were reported in either groups. In our experience PD was an effective and safe procedure both in young and old patients although the older group had more recurrences, all successfully re-dilated.
      PubDate: 2015-01-28
      DOI: 10.14800/abdomen.512
      Issue No: Vol. 3 (2015)
  • Clinical outcomes of self-expandable metallic stents in palliation of
           malignant anastomotic strictures: a single center experience

    • Authors: Dario Raimondo, Emanuele Sinagra, tiziana facella, francesca rossi, marco messina, massimiliano spada, guido martorana, pierenrico marchesa, rosario squatrito, giovanni tomasello, attilio ignazio lo monte, giancarlo pompei, gaetano cristian morreale, georgios amvrosiadis, marco ciofalo, ennio la rocca
      Abstract: Background: Self-expandable metallic stents (SEMS) are used as the main nonsurgical palliative treatment for malignant gastric outlet obstruction. Metal stents are also used to treat malignant anastomotic obstructions after esophagojejunostomy, gastrojejunostomy and esophagogastrojejunostomy. Methods: This case series reports prospectively the clinical outcomes of SEMS in the palliation of malignant anastomotic strictures caused by recurrent gastric cancer following gastric surgery as oncological curative treatment, in a series of nine consecutive patients, treated between January 2009 and December 2012 in our center.Results: Nine patients (M:F=8:1) were included. The operation was a total gastrectomy with esophagogastrojejunostomy (n=4), subtotal gastrectomy with Billroth-II reconstruction (n=3), and subtotal gastrectomy with esophagogastrostomy (n=2) .The technical and clinical success rates were 88,9 % and 88,9 %, respectively. The reobstruction of the stent, caused by tumor ingrowth, occurred in 1 patient (11,1%) within 1 month after stenting. Stent migration occurred with a covered stent in 1 patient who underwent a subtotal gastrectomy with Billroth-II reconstruction. A case of partial stent migration was easily treated with a second stent. The median survival period was 180 days (range, 30-240 days) and the median stent patency was 45 days (range, 30-90 days).Conclusions: Although the number of the patients treated with SEMS results, in this series, almost small to certainly judge the safety and feasibility of SEMS, we believe that the endoscopic insertion of  SEMS seems to be a safe, technically feasible, and effective treatment for the palliation of anastomotic strictures caused by recurrent gastric cancer. The technical and clinical success, and the onset of complications of this procedure are influenced by several factors, such as the type of anastomosis, the technical features of the stent, and the extent of the underlying tumor.
      PubDate: 2015-01-28
      DOI: 10.14800/abdomen.511
      Issue No: Vol. 3 (2015)
  • Quality assessment of YouTube videos as a source of information on

    • Authors: Nancy Gupta, Gurprataap Sandhu, Arun Aggarwal, Harkirat Singh, Leanne Forman
      First page: 10
      PubDate: 2015-09-02
      DOI: 10.14800/abdomen.953
      Issue No: Vol. 2, No. 2 (2015)
  • Treatment of acute esophageal variceal bleeding in cirrhotic patients

    • Authors: Dmitry Victorovich Garbuzenko
      First page: 10
      Abstract: Esophageal variceal bleeding is the most dangerous complication in cirrhotic patients and is accompanied by high mortality. Treatment strategy involves early diagnosis, maintaining vital body functions and specific therapy aimed at the provision of local hemostasis and reduction of portal pressure. To this end, it is currently recommended to combine vasoactive drug (mainly, terlipressin or somatostatin) therapy with endoscopic methods of hemostasis (sclerotherapy or ligation). The use of Sengstaken-Blakemore tube is appropriate only in cases of refractory bleeding if the above methods cannot be used. An alternative to balloon tamponade may be the installation of self-expandable metal stents. Although transjugular intrahepatic portosystemic shunting is an extremely useful technique for the treatment of acute bleeding from esophageal varices, currently it is viewed as second-line therapy. Urgent surgical intervention is rarely performed and can be considered only in case of failure of conservative and/or endoscopic therapy and being unable to use a transjugular intrahepatic portosystemic shunt for technical or organizational reasons or due to anatomic problems. Among surgical operations described in the literature are various kinds of portocaval anastomoses and azygoportal disconnection procedure. To improve the results of treatment of cirrhotic patients with acute esophageal variceal bleeding it seems important to stratify them by risk groups, which will allow one to tailor therapeutic approaches to the expected results. For example, to initiate early use of more aggressive methods in patients with predictors of poor outcomes, and to protect individuals with a good prognosis from unnecessary invasive procedures. It is hoped that further research will refine this hypothesis.
      PubDate: 2015-08-25
      DOI: 10.14800/abdomen.958
      Issue No: Vol. 2, No. 2 (2015)
  • Adult hepatic hemangioma; An Updated Review with focus on the natural
           course and treatment options

    • Authors: tawfik khoury
      First page: 10
      Abstract: Hemangiomas are the most common benign tumor of the liver; females are affected more than males. Mostly, hepatic hemangiomas are asymptomatic and incidentally diagnosed. In this review, we provide an updated discussion on the clinical presentation of hepatic HA as well as on the natural history and available treatment options. Overall the natural history of hepatic HA is benign, although a caution should be taken for the catastrophic complication. Mostly a conservative treatment is recommended unless there is an absolute indication for surgical intervention. Until now, there is no approved effective oral treatment for hepatic HA and given the high efficacy and safety of propranolol treatment in infantile hepatic and cutaneous HA. The use propranolol should be encouraged in adult patients with giant hepatic HA.
      PubDate: 2015-07-28
      DOI: 10.14800/abdomen.908
      Issue No: Vol. 2, No. 2 (2015)
  • Cirrhotic Cardiomyopathy; Pathophysiology and Clinical Approach

    • Authors: Dalia Omran
      First page: 10
      Abstract: Cardiac dysfunction is frequently observed in patients with cirrhosis. Cirrhotic cardiomyopathy (CCM) has recently been identified as an entity independent of the cirrhosis etiology. Increased cardiac output due to hyperdynamic circulation, systolic and diastolic left ventricular dysfunction and certain electrophysiological abnormalities are the pathophysiological features of the disease. The main underlying mechanisms are complex, including the impaired β-receptor and calcium signaling, altered cardiomyocyte membrane physiology, elevated sympathetic nervous tone and increased activity of vasodilatory pathways.  CCM is characterized by impaired cardiac response to physical, physiological and pharmacological stress. Currently, no specific therapy has proved effective yet. Echocardiography and electrocardiography are the corner stones for diagnosis. In this review, we discuss in brief the pathophysiological bachground and clinical features of cirrhotic cardiomyopathy, diagnosis and the currently available treatment options.
      PubDate: 2015-06-08
      DOI: 10.14800/abdomen.836
      Issue No: Vol. 2, No. 2 (2015)
  • Research progress on hepatic encephalopathy: animal models and disease

    • Authors: Jingjing Li, Jia Xiao, Kwok Fai So
      First page: 10
      Abstract:  Hepatic encephalopathy (HE) is a hepatic disease with neuronal confusion, altered level of consciousness, and coma as a result of severe liver damage/failure. HE is with complicated pathological mechanisms and high mortality, which seriously affects patients' daily life. Roughly, it can be divided into three types, A, B and C. Type A is acute HE and Types B and C are chronic. At present, the pathogenesis of HE is still unclear. In addition, there is no specific clinical treatment. Therefore, establishing appropriate HE animal model is vital for the mechanistic study of the disease and the development of clinical therapy. This review makes a summary on the recent progress of HE animal model establishment and current study of its underlying molecular mechanisms. 
      PubDate: 2015-04-13
      DOI: 10.14800/abdomen.770
      Issue No: Vol. 2, No. 2 (2015)
  • Regulation of tonicity-dependent activation of NFAT5 by mitogen-activated
           protein kinases

    • Authors: Xiaoming Zhou
      First page: 10
      Abstract: Various tissues, most notably the kidney medulla, are normally exposed to a hypertonic environment. The transcription factor NFAT5 is essential for these tissues to survive and function properly by activating expression of the osmoprotective genes and genes that are unique for the functions of these tissues. Moreover, hypertonicity causes or is associated with certain diseases and disorders such as diabetes mellitus and inflammation. NFAT5 plays an important role in pathogenesis of these diseases and disorders. Hypertonicity activates NFAT5 through phosphorylation of signaling molecules or NFAT5 itself. More than a dozen of kinases have been identified. This mini-review will focus on mitogen-activated protein kinases (MAPKs), which include p38, ERK and JNK families, because they are the most studied kinases in regulation of NFAT5. p38alpha, ERK1/2 and some of their upstream kinases have been demonstrated to contribute to tonicity-dependent activation of NFAT5 by increasing its transactivating activity without significantly affecting its nuclear accumulation. However, many important questions remain. For example, hypotonicity, which inhibits NFAT5 activity, also activates p38 and ERK1/2, raising a question concerning how p38 and ERK1/2 relay the hypertonic signal to NFAT5.  The present mini-review calls for attention to MAPKs isoforms, duration and strength of activation, cellular localization and interaction with specific scaffolds and other signaling molecules, when they are studied for their roles in regulation of NFAT5. Further, whether MAPKs regulate NFAT5 in the tissues remains to be addressed.    
      PubDate: 2015-04-13
      DOI: 10.14800/abdomen.767
      Issue No: Vol. 2, No. 2 (2015)
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