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Publisher: Smart Science and Technology LLC   (Total: 20 journals)   [Sort by number of followers]

Showing 1 - 20 of 20 Journals sorted alphabetically
Abdomen     Open Access  
Cancer Cell & Microenvironment     Open Access   (Followers: 10)
Cardiovascular Regenerative Medicine     Open Access  
Evidence-based Medicine & Public Health     Open Access   (Followers: 8)
Immunoendocrinology     Open Access   (Followers: 1)
Itch & Pain     Open Access   (Followers: 2)
J. of Advanced Nutrition and Human Metabolism     Open Access   (Followers: 15)
Macrophage     Open Access  
Molecular & Cellular Epilepsy     Open Access   (Followers: 2)
Musculoskeletal Regeneration     Open Access   (Followers: 3)
Neurotransmitter     Open Access  
Precision Medicine     Open Access   (Followers: 2)
Receptors & Clinical Investigation     Open Access   (Followers: 1)
RNA & Disease     Open Access   (Followers: 1)
Science Proceedings     Open Access   (Followers: 1)
Stem Cell and Translational Investigation     Open Access   (Followers: 2)
Stem Cell Epigenetics     Open Access   (Followers: 3)
Telomere and Telomerase     Open Access  
Therapeutic Targets for Neurological Diseases     Open Access   (Followers: 1)
Uterus & Ovary     Open Access  
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Science Proceedings
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2375-7795
Published by Smart Science and Technology LLC Homepage  [20 journals]
  • The Subcellular Compartment for Endoplasmic Reticulum-Associated
           Degradation of Exogenous Antigens from dendritic cells

    • Authors: Mayu Otani, Takahiro Sakai, Shinichi Hatta
      Abstract: Dendritic cells (DCs) have the unique ability of processing and presenting exogenous antigens upon major histocompatibility class I (MHC I) molecules. This ability is called antigen cross-presentation (CP) and plays not only in the activation of naïve CD8+ T into anti-infectious and anti-tumoral cytotoxic CD8+ T cells, but also in the inactivation of self-acting naïve T cells by T cell anergy or T cells deletion. Since antigen CP was first described more than four decades ago, so many numbers of studies, by using a variety of sources of antigens and antigen-presenting cells (APCs), had been carried out to solve the cellular process of CP. There are accumulating in vivo and in vitro evidences that endoplasmic reticulum (ER)-associated degradation (ERAD) acts as a key player in CP. But for all these efforts, the precious molecular mechanisms for CP are still remained to be elucidated. It may be partially because there are several pathways for CP running alongside with each other and each cell uses these several pathways redundantly responding against environmental conditions. Here, we review the intracellular transport routes for exogenous antigens and the subcellular compartment in which exogenous antigens undergo ERAD.
      PubDate: 2017-01-17
      DOI: 10.14800/sp.1490
      Issue No: Vol. 4 (2017)
  • Rituximab dosing in B cell lymphoma

    • Authors: Mitchell R Smith
      Abstract: Rituximab has been extensively used in the treatment of CD20-expressing B cell neoplasms in the last two decades. Despite that, its dose and scheduling are still being questioned as they are supported my minimal scientific evidence. Our retrospective study of patients with indolent B cell lymphoma showed that older males and patients with higher weight had worse outcomes when treated with first line rituximab-containing chemotherapy, probably due to faster rituximab clearance. This suggests that a subset of patients with indolent B cell lymphoma may be sub-optimally dosed with rituximab as commonly administered. These results are in line with other studies in aggressive lymphoma where rituximab pharmacokinetics were shown to be affected by gender, age and weight and can affect outcomes. Our study also highlights the challenge of presenting the newer anti-CD20 monoclonal antibodies as intrinsically superior to rituximab when they are given at higher dose and more frequent administration.
      PubDate: 2016-12-05
      DOI: 10.14800/sp.1463
      Issue No: Vol. 3 (2016)
  • Effects of Acrolein on Adrenal Glands

    • Authors: Kai-Lee Wang
      Abstract: Aldosterone and cortisol, two major hormones secreted from adrenal glands, are vital to life by maintaining electrolyte, body fluid and energy homeostasis in human. Both of hormones are regulated precisely. Acrolein, the well-known cytotoxic agent released during the incomplete combustion. It abounds in the smoke of cigarette and in enclosed fires. Previous studies have demonstrated that smoking has the adverse effects on cardiovascular, nerve and other system. In particular, the pathogenic functions of tobacco inhalation in cardiovascular disorders as well as alters plasma electrolyte levels have been well documented. It is thus important to evaluate cellular/molecular mechanisms of smoking that change these responses. In a recent paper published in Steroids, we demonstrated that the major chemical in cigarette, acrolein, has the abilities to enhance aldosterone secretion and decrease corticosterone secretion. These effects may associate with the progression of cardiovascular and other diseases.
      PubDate: 2016-09-26
      DOI: 10.14800/sp.1428
      Issue No: Vol. 3 (2016)
  • Dual-targeting of MEK and CDK4/6 in KRAS-mutated Non-Small Cell Lung

    • Authors: Justin M Le Blanc, Nicholas G Zaorsky, Bo Lu
      Abstract: Discovering new ways to modulate the responsiveness of non-small cell lung cancer (NSCLC) to treatment represents one of the forefronts of cancer research. KRAS mutations, present in roughly 30% of NSCLCs, lead to increased levels of cellular proliferation and decreased responsiveness to treatment modalities. The present study examined the RB/p16/CDK4 pathway as a way to modulate the responsiveness of these cell lines. The diverse downstream effects of these pathways suggest that molecular profiling of NSCLCs may assist clinicians and researchers to predict the effectiveness in the application of particular therapeutics.
      PubDate: 2016-07-05
      DOI: 10.14800/sp.1363
      Issue No: Vol. 3 (2016)
  • Novel role of Parkinson’s protein DJ-1/Park7 in the development of
           Foxp3+ regulatory T cells

    • Authors: Yogesh Singh, Madhuri S Salker, Florian Lang
      Abstract: Parkinson’s protein DJ-1/Park7, is a key regulator of redox signalling in neurons and muscles by regulating reactive oxygen species (ROS) production. Defects in DJ-1 are suggested to cause autosomal recessive early-onset Parkinson's disease. Further, deregulated DJ-1 signalling has been ascribed to other pathologies including diabetes (type II) and in obesity. How DJ-1/Park7 is involved in the maintenance of immune T cells especially suppressor regulatory T cells (Tregs) is not well defined. We explored this important question by using DJ-1 knock-out mice at cellular and molecular level. We found that DJ-1 is involved, both in vivo and in vitro, in the development of natural and induced Tregs. Differentiation of induced Tregs is regulated by mammalian target of rapamycin (mTOR)/Serum and glucocorticoid kinase 1 (Sgk1) and ROS/NFƙB pathway. Thus, our data highlights the importance of DJ-1 in the development of Tregs.
      PubDate: 2016-05-09
      DOI: 10.14800/sp.1285
      Issue No: Vol. 3 (2016)
  • Conceptual design for critically-high power generation efficiency by using
           multi-stage solid oxide fuel cells (SOFCs) or proton-conducting ceramic
           fuel cells (PCFCs)

    • Authors: Yoshio Matsuzaki, Yuya Tachikawa, Takaaki Somekawa, Koki Sato, Hiroshige Matsumoto, Shunsuke Taniguchi, Kazunari Sasaki
      Abstract: Recently we have developed the conceptual design for realizing a critically-high electrical efficiency with solid oxide fuel cells (SOFCs). SOFCs are promising electrochemical devices that enable the highest fuel-to-electricity conversion efficiencies under high operating temperatures. The concept of multi-stage electrochemical oxidation using SOFCs has been proposed and studied over the past several decades for further improving the electrical efficiency. However, the improvement is limited by fuel dilution downstream of the fuel flow. Recently we developed and reported a conceptual design that has a potential to realize a critically-high fuel-to-electricity conversion efficiency of up to as high as 85% (LHV, gross DC), in which a high-temperature multi-stage solid oxide fuel cells (SOFCs) is combined with a proton-conducting solid oxide electrolyte. Switching a solid electrolyte material from a conventional oxide-ion conducting material to a proton-conducting material under the high-temperature multi-stage electrochemical oxidation mechanism has proven to be highly advantageous for the electrical efficiency. The DC efficiency of 85% (LHV) corresponds to a net AC efficiency of approximately 77% (LHV), where the net AC efficiency refers to the transmission-end AC efficiency. This evolved concept will yield a considerably higher efficiency with a much smaller generation capacity than the state-of-the-art several tens-of-MW-class most advanced combined cycle (MACC). In the conceptual design the proton-conducting electrolyte was assumed to have a protonic transport number of 1. However, the protonic transport number of the proton-conducting solid oxide electrolyte depends on the material and operating conditions such as temperature, oxygen partial pressure, kinds of fuel and so on, and would affect the electrical efficiency. Therefore, to realize the critically-high electrical efficiency by using the multi-stage electrochemical oxidation, proton-conducting solid oxide having a high ionic transport number should be developed.
      PubDate: 2016-05-02
      DOI: 10.14800/sp.1272
      Issue No: Vol. 3 (2016)
  • Nicotine and the taste allure for salty food

    • Authors: Albertino Bigiani
      Abstract: Smoking has been recognized as one agent that may decrease the effectiveness of the gustatory system to detect salt (Na+) in foodstuffs. As a consequence, smokers tend to ingest saltier foods than nonsmokers. An increase in sodium intake has been associated with hypertension: thus, smoking may concur to the development of  hypertension by impairing salt perception. Understanding the mechanisms underlying the action of smoking on salty taste represents the premise to design proper intervention aiming at restoring normal sensitivity to sodium in smokers. I addressed this issue by studying the effect of nicotine, one of the main components of tobacco smoke, on the sodium detection mechanism in rat taste cells. Electrophysiological analysis of these cells revealed that long-term exposure to nicotine reduced the ion current mediated by the Epithelial Sodium Channel (ENaC), one of the sodium receptors occurring in taste cells. As to the molecular mechanism responsible for such a current decrease, data were consistent with a reduction in the number of functional ENaCs in the membrane of taste cells. Therefore, nicotine reduces the capability of taste cells to respond to sodium ions. This might explain, at least in part, why smokers tend to use salt more abundantly when flavoring their food: they are just boosting the sensory information to be relayed to the brain.
      PubDate: 2016-01-04
      DOI: 10.14800/sp.1133
      Issue No: Vol. 3 (2016)
  • Osteogenic Differentiation of Adipose-Derived Stromal Cells: Advancements
           and Future Directions for Bone Tissue Engineering

    • Authors: Graham G Walmsley, Alexander T Cheung, Michael S Hu, H. Peter Lorenz, Michael T Longaker
      Abstract: Adipose-derived stromal cells (ASCs) present a promising cell source for tissue engineering applications. ASCs are attractive due to their abundance and ease of procurement through subcutaneous liposuction and subsequent isolation from lipoaspirates. ASCs are also preferable to more controversial stem cell sources due to ethical considerations and potential for teratoma formation. Recent approaches to promote osteogenesis have incorporated potent agents such as exogenous osteogenic growth factors, substrate-induced differentiation using mechanical properties of scaffolds, and genetic modification using viral vectors, RNAi, and nanotechnology. In this manuscript we review current literature on methods for the differentiation of ASCs for the purpose of improving bone tissue engineering.
      PubDate: 2016-01-04
      DOI: 10.14800/sp.1085
      Issue No: Vol. 3 (2016)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
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