Journal Cover Jurnal Sain Veteriner
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   ISSN (Print) 0126-0421 - ISSN (Online) 2407-3733
   Published by Universitas Gadjah Mada Homepage  [27 journals]
  • Ancaman Masuknya Virus Penyakit Mulut dan Kuku Melalui Daging Ilegal di
           Entikong, Perbatasan Darat Indonesia dan Malaysia

    • Authors: Risma JP Silitonga
      Pages: 147 - 154
      Abstract: This study was aimed to analyze the risk of FMD virus to enter Indonesia by the presence of illegal meat at Entikong, a borderland between Indonesia and Malaysia. The primary datas were collected using questionnaires method to collect expertise, in-depth interviews, and direct field observations. Secondary datas were obtained from scientific publications and articles or unpublished datas (statistics, goverment documents and reports). The respondents were choosen by purposive sampling. The circulating illegal meat was possibly originate from
      different countries, including FMD-endemic countries/zones such as Peninsular Malaysia, Thailand, India and even unidentified countries/zones according to our respondends. The types of illegal meat such as frozen deglanded bonein-meat and frozen deglanded offal that enter Entikong carry the risk of becoming a source of FMD infection. Based on the entry route, delivery frequency, and meat volume, ilegal meat was possibly also entered into Indonesia using non-vehicular transportation. These conditions indicated that the entrance of illegal meat could pose risk of the FMD virus entry to Indonesia, especially at the borderland between Indonesia and Malaysia at Entikong. It is highly recommended to apply strict inspection at the border entraces and increase collaboration with related institutions to prevent the entrance of illegal meat and to reduce the entry risk of FMD virus.
      PubDate: 2017-08-16
      DOI: 10.22146/jsv.27222
      Issue No: Vol. 34, No. 2 (2017)
  • Pengembangan Metode Identifikasi Kerusakan DNA Spermatozoa Ternak

    • Authors: Teguh Ari Prabowo, R. Iis Arifiantini, Dondin Sajuthi, Uus Saefullah
      Pages: 166 - 171
      Abstract: The success of artificial insemination is very much determined by the quality of spermatozoa. The detection or identification of damaged chromatin of spermatozoa DNA is very important to forsee the adverse clinical outcome. However, the method of identification is still depended on expensive imported kits. Therefore, the objective of this research was to developed an identification kit to determine the quality of livestock spermatozoa DNA chromatin.This study consist of three step. Step 1) Determination of low melting point agarose (LMP-agarose) concentration which is 0,6%, 0,7% and 0,8%. 2) Comparison of three lysis solution (LS) which is LS I (0.4M Tris, 0.8M DTT, 1% SDS, pH 7.5), LS II (0.4M Tris,2 M NaCl, 1% SDS , pH 7.5), and LS III (0.4M Tris-HCl, 2M NaCl, 1% SDS 0,05 M EDTA, pH 7.5). 3) Comparison different staining which is Eosin yellow and Methylene blue. The results showed that 0.6% LMP-agarose demonstrated the best concentration to “trapped the spermatozoa” compared for sheep and goats. whereas the three concentration of spermatozoa cows can not be used to trap spermatozoa cow. The best formulation to lysis the membrane was LS III (0.4M Tris -HCl, 2M NaCl, 1% SDS 0,05 M EDTA). The best staining was eosin yellow and methylene blue with 2:1 ratio.
      PubDate: 2017-08-16
      DOI: 10.22146/jsv.27538
      Issue No: Vol. 34, No. 2 (2017)
  • Peran Makromineral pada Reproduksi Ruminansia

    • Authors: Yanuartono Yanuartono, Soedarmanto Indarjulianto, Alfarisa Nururrozi, Hary Purnamaningsih
      Pages: 155 - 165
      Abstract: Macromineral is one component of a nutrient that has an important role in the growth, health, production,reproduction and immune system of animals. Ruminants need makromineral such as Ca, P, Mg, K, Na , Cl and S. Mineral needs of ruminant affected by several factors such as their age, pregnancy and lactation status.
      Mineral deficiency can cause disturbances in reproduction ruminant. Ca and P have direct influence while Mg, K, Na, Cl and S acted indirectly on reproductive function. A complete understanding of the role macromineral on ruminant reproductive function is indispensable for the prevention of their reproductive disorders due to
      improper feeding minerals.
      PubDate: 2016-12-01
      DOI: 10.22146/jsv.27541
      Issue No: Vol. 34, No. 2 (2016)
  • Deteksi Spesies Brucella pada Kambing di Rumah Potong Hewan Jakarta

    • Authors: Mujiatun Mujiatun, Retno Damajanti Soejoedono, Etih Sudarnika, Susan Maphilindawati Noor
      Pages: 172 - 181
      Abstract: Brucellosis is a zoonosis and occupational diseases transmision. The diseases caused by bacterial and attack multiple species of animals. Common species that infects goats as the most pathogenic species (zoonotic) is Brucella melitensis; however, the species B. abortus could also infect goats. The study purposed to find out the brucellosis seropositive in goat in Jakarta slaughterhouse and to detect caused agent of brucellosis. Sampling was done through slaughtered goats that come from brucellosis endemic area. The samples were collected from
      slaughtered mature female goats i.e serum, goat milk, vaginal swab, mamary gland, limphoglandula supramamary, limph, and uterus. The detection method was used i.e patological lession, serological, culture and Polymerase
      Chain Reaction (PCR) technique. The serological detection of brucellosis in goats was done parallelly between Rose Bengal Test (RBT), Complement Fixation Test (CFT) and Enzyme Linked Immunosorbent Assay (ELISA). The results of this study demonstrated that out of the 119 serum samples serologically tested, negative for RBT, one was positive for CFT and none were positive with ELISA. Patological observation in the Brucella predilection organs, there were 5 goat carcases showed pathological lession (vagina discharge, hemoragy at limph
      and limphoglandula, crumbly limph and there were pus in uterus). The serum samples that had reacted positively and the organs with pathological lesion were confirmed further with PCR, bacterial isolation and identification.
      The PCR test results and the culture of milk samples, vaginal swabs and organs did not reveal any Brucella spp bacteria (B. abortus, B. melitensis, B. ovis dan B. suis) and also vaccine strains of RB51. Based on these results, it was concluded that brucellosis in goats on Java Island was a 0.84% seropositive (confidence interval 95%; 0.00826 - 0.00854) (1/119), although the species of Brucella that had infected them remains unknown.
      PubDate: 2016-12-01
      DOI: 10.22146/jsv.27546
      Issue No: Vol. 34, No. 2 (2016)
  • Sonogram Pemeriksaan Kebuntingan Dini pada Kambing Kacang (Capra hircus)

    • Authors: Santoso Santoso, Amrozi Amrozi, Bambang Purwantara, Herdis Herdis
      Pages: 188 - 192
      Abstract: This study was conducted to determine the earliest day of pregnancy diagnosis in kacang goat using transrectal ultrasonography. The goat were synchronized by using prostaglandin in the luteal phase. Pregnancy was determined by isoechogenic visualization surrounded by hypoechogenic. Early pregnancy was detected on days 20 of embryonic vesicle diameter 1.2±0.1 cm. Fetus was detected on days 22 with a long gestation fetus 0.4±0.1 cm. Average increase until days 30 pregnancy was 0.19 ± 0.1 cm per day. Development of fetus was followed by an increasing the diameter and thickness of uterus. The diameter of uterus increased from days 14 (0.8 ± 0.3 cm) until days 30 (3.6 ± 0.2 cm), and thickness of uterus increased from days 14 (0.4 ± 0, 2 cm) until days 30 (1.8 ± 0.2 cm). It could be concluded that the earliest pregnancy diagnosis showed positive sign on days 20 and fetus was earliest observed on days 22.
      PubDate: 2016-12-01
      DOI: 10.22146/jsv.27548
      Issue No: Vol. 34, No. 2 (2016)
  • Efek Antikariogenik Ekstrak Daun Beluntas (Pluchea indica) sebagai
           Penghambat Pertumbuhan Streptococcus Mutans penyebab Karies Gigi

    • Authors: Nungki Fatimatuzzahra, Nourmalita Safitri Ningsih, Feny Feny, Adam Darsono, Siti Isrina Oktavia Salasia
      Pages: 182 - 187
      Abstract: Anti-plaque agents are known to reduce the formation of dental biofilms such as fluoride and chlorhexidine. However, excessive use of fluoride causes fluorosis and chlorhexidine side effects caused genotoxic. Pluchea indica L is one of the abundance of tropical herbs in the Asia-Pacific reported to have antiinflammatory
      properties and reduces the incidence of gastric necrosis, antinociception, neutralizing toxic venom, antioxidant, antiulcerative, hepatoprotective, antimoeba and broad-spectrum antimicrobial. This study examines
      the effectiveness anticariogenic Pluchea indica leaf extract in inhibiting the growth of Streptococcus mutans causing dental caries in vitro. Determination of Minimum Inhibitoric Concentration (MIC) on Pluchea indica leaf
      extract is by diffusion test on the growth of Streptococcus mutans by Kirby Bauer Test. S. mutans concentration Mc Farland 0.5 standard (108 CFU ml-1) were inoculated in media Müller-Hinton agar (MHA). Paper disk
      containing Pluchea indica leaf extract at each concentration of 10%, 20%, 30%, 40%, 50%, 60%, and 70% were placed in an agar medium inoculated bacteria then incubated at 37°C on condition microaerophilia using candle
      jar. Determination of significance various Pluchea indica leaf extract concentration using one-way ANOVA test. The result of the diffusion method showed Pluchea indica leaf extract at a minimum concentration of 10% been
      able to establish inhibited zone of Streptococcus mutans growth in MHA media. By one-way ANOVA test to various concentrations of extracts using Microsoft Excel 2007 have been obtained with F=4.85, Fcrit = 2.85 and
      P-value = 0.0071. Based on this research, it was concluded that Inhibitoric Minimum Concentration Pluchea indica leaf extract is capable of effective concentration of 10% and it has a significant (P-value< 0,05) of various
      DOI: 10.22146/jsv.27547
      Issue No: Vol. 34, No. 2
  • Studi Respon Imun Humoral Mencit, Tikus, dan Ayam terhadap Infeksi
           Toxoplasma Gondii

    • Authors: Gifti Rosalina Ratnaningrum, Dana Meida, Andhini Mutiara Putri, Hilda Syara Shita Devi, Dwi Priyowidodo
      Pages: 194 - 197
      Abstract: Toxoplasmosis is a disease caused by the protozoan Toxoplasma gondii. T. gondii is an obligate intracellular parasite that is transmitted by congenital and acquisition. T. gondii can infect all warm-blooded animals and are zoonotic. It is estimated that more than a third of the world’s population is infected by T. gondii. Chicken is one of the animals that can be infected with T. gondii and plays an important role in the spread of this disease to humans because it is one of the animals used as a source of animal feed. Mice and rats are also play an important role in the spread of toxoplasmosis in the definitive host, especially in cats. T. gondii infection is usually asymptomatic, but in certain circumstances, such as when the host’s immune system is weakened, this parasite can cause
      serious illness. This study were aimed to determine the humoral immune response against T. gondii infection in mice, rats and chickens by serological Latex Agglutination Test (LAT) using Pastorex-Toxo® kit. Two weeks old
      broiler chickens were 8 heads, Wistar strain rats aged 8 weeks as many as 18 heads and strain Balb C mice aged 8 weeks as many as 13 cows used in this study. Animals were grouped into two groups, namely the control and
      infection groups. Mice, rats, and chickens were infected each with 103, 107 and 105 takizoit by intra-peritoneal injection. Blood samples were taken from the animals and infection control from day to-1, 2, 3, 4, 5, 6 for mice,
      the to-1, 2, 3, 4, 5, 6, 7, 8 for rats, and day - 2, 4, 14 for chicken by intracardia 3 ml, then put in a non-EDTA tubes and centrifuged at a speed of 10,000 rpm for 5 minutes to collect serum. The results showed a humoral immune
      response against T. gondii in rats began to appear on day 5 post-infection, chickens began to emerge the 2nd day post infection, whereas mice do not indicate a humoral immune response against T. gondii post infection.
      DOI: 10.22146/jsv.27556
      Issue No: Vol. 34, No. 2
  • Potensi Ekstrak Daun Sage (Salvia officinalis.L) sebagai
           anti-Streptococcus suis Penyebab Zoonotik Meningitis

    • Authors: Mitra Slipranata, Fajar Budi Lestari, Novra Arya Sandi, Siti Isrina Oktavia Salasia
      Pages: 198 - 202
      Abstract: The phenomenon of microbial resistance to an antibiotic or some kind of specific antibiotics (multi drugs resistance) greatly complicate the treatment process, one of which is Streptococcus suis (S. suis) which is known to cause meningitis in animals and humans. Today, with rising bacterial resistance to a wide range
      of antibiotics, it takes an effort to assess the potential medicinal plants as an antibiotic that is appropriate and safe. Sage (Salvia officinalis.L) is reported to have antibacterial and fungicidal effect. Phenolic acids such as
      salvin and ether monomethyl salvin which isolated from the sage thought to have antimicrobial activity against several bacterial strains. The purpose of this study was to prove the ability of sage leaf extract as an antibacterial
      against S. suis causes streptococcal meningitis in vitro. In-vitro method used in this research through a two-stage dilution test and the diffusion test on Mueller Hinton Agar (MHA). S. suis isolates (code 225) were tested in vitro against 8 levels sage leaf extract concentration, ie a concentration of 1%, 3% 5%, 7%, 10%, 20%, 40% and 60%. The results of the test obtained by minimum inhibitory concentrations (MICs) and minimum sage known to potentially inhibit the growth of S. suis.
      DOI: 10.22146/jsv.27558
      Issue No: Vol. 34, No. 2
  • Kesembuhan Skin Flap H-Plasty dan Linear Closure untuk Penutupan Luka Area
           Lateral Thoraks

    • Authors: Erwin Erwin, Deni Noviana, Gunanti Gunanti, I Gusti Agung Ngurah Arphan Eka Putra
      Pages: 203 - 209
      Abstract: Skin flap is one of the techniques use for large wound closure. This study were aimed to determine the rate of cure of skin flap H-plasty and linear closure based on subjective and objective clinical observation. Six male local cats at 1-2 years old, weighing 3-4 kg, were divided into two treatment groups. All cats were made 3 x 3 cm wound in the thoracic area for skin graft. Thoracic defects were treated with skin flap techniques H-plasty (group I) and linear closure (group II). Subjective observations was performed on days 3, 6, 9 and 12 after skin flap which was covering skin discoloration, pain response, time hair growth as well a bleeding tests that performed on the 18th day after the skin flap. Objective observation was made on day 18 by administration of 0.9% NaCl
      and observed the absorption time, while the onset of drug effect was noticed by pupillary reflex observation after 0.2 ml adrenaline injection under the skin flap. The observation on day 9 showed that skin flap linear closure was
      better than skin flap H-plasty, which was characterized by similar skin color with surrounding skin, reduced pain response and rapid hair growth. Bleeding blood test was showed a glowing red colored and immediately came out
      after incision in both groups. The absorption time of 0.9% NaCl and the effects of adrenaline were faster in the
      group skin flap linear closure. Skin flap H-plasty and linear closure techniques can be applied to repair wounds
      in the thoracic area of cat skin, however, the linear closure flap of skin was healing faster than skin flap H-plasty.
      DOI: 10.22146/jsv.27559
      Issue No: Vol. 34, No. 2
  • Konsumsi, Kecernaan Nutrien, Perubahan Berat Badan dan Status Fisiologis
           Kambing Bligon Jantan dengan Pembatasan Pakan

    • Authors: Bambang Suwignyo, Ulil Amri Wijaya, Rieska Indriani, Asih Kurniawati, Irkham Widiyono, Sarmin Sarmin
      Pages: 210 - 219
      Abstract: This study were aimed to determine the dry matter and organic matter intake, nutrients digestibility, body weight gain and physiological status of male Bligon goats treated with feed restriction. Six Bligon goats average age of 12 months and an average body weight of 23.6 kg were fed 40% of peanut raughages (rendeng) and 60% concentrate. Goats were divided into two (2) treatment groups. Control goat treatment were fed diets based on dry matter (DM) requirements 3.5% of body weight, and feed restriction goat treatment were fed diets with 50% reduction of DM requirement. Feed restriction was conducted for 35 days. The variables measured were dry matter (DM) and organic matter (OM) intake, total digestibility nutrient (TDN) intake, body weigh gain, dry matter (DM) and organic matter (OM) digestibility, rectal temperature, respiration frequency, and heart rate. Data were analyzed by independent samples T-test. The results showed that the feed restriction significantly decreased
      consumption of DM (676.07 ± 14.76 into 372.30 ± 53.08) and OM (639.38 ± 15.89 into 349.88 ± 49.35), consumption of TDN (461.60 ± 10.23 into 253.99 ± 36.17), DM digestibility (74.39 ± 1.60 into 71.27 ± 0.89) and OM digestibility (79.42 ± 1.54 into 76.34 ± 0.24), but had no significant effect on body  temperature, respiration frequency and heart rate (pulsus) of male Bligon goat. Value of ADG was 55.24 g/day (P0) then increased to 131.43 g/day when the feed was filled back. A feed restriction up to 50% decreased goat production performance, but did not interfere with the health status of livestock (can be indicated from physiological status of goat still in the normal range).
      DOI: 10.22146/jsv.27560
      Issue No: Vol. 34, No. 2
  • MPPA (Most Probable Producing Ability) Estimation of Kebumen Ongole
           Crossbred Cattle based on Offsprings Weaning Weight

    • Authors: Sumadi Sumadi, Nono Ngadiyono, Diah Tri Widayati, Cuk Tri Noviandi, Akhmad Fathoni, Mukhamad Khusnudin
      Pages: 220 - 224
      Abstract: Tujuan dari penelitian ini yaitu untuk menghitung nilai MPPA induk pada sapi PO Kebumen. Penelitian ini telah dilakukan pada bulan Juli sampai dengan Oktober 2015 di wilayah Urut Sewu, Kebumen. Materi penelitian yang digunakan adalah data recording tiga tahun terakhir (2013-2015) terdiri dari 41 ekor pejantan, 51 induk dan 244 pedet. Data berat sapih anak sebelumnya telah dikoreksi berdasarkan umur induk, jenis kelamin dan umur penyapihan 120 hari. Ripitabilitas dihitung menggunakan metode korelasi antarkelas. Nilai MPPA induk dihitung berdasarkan nilai ripitabilitas berat sapih keturunan. Hasil penelitian menunjukkan bahwa nilai ripitabilitas berat sapih anak termasuk dalam kategori tinggi (0.32 ± 0.15). Nilai MPPA induk sapi PO Kebumen kemudian dihitung menggunakan nilai tersebut dan juga rata-rata performan populasi (83.45 kg). Dihasilkan 10 besar induk sapi PO Kebumen dengan nilai MPPA tertinggi. Nilai MPPA kemudian diurutkan dari nilai tertinggi ke terendah. Nilai MPPA tertinggi dimiliki oleh SAJ0315078 (110.69) dan terendah dimiliki oleh TA1112020 (97.20). Hasil dari penelitian ini kemudian dapat digunakan sebagai dasar dalam seleksi induk sapi PO Kebumen di dalam populasinya.
      DOI: 10.22146/jsv.27561
      Issue No: Vol. 34, No. 2
  • Kemampuan Fertilisasi Spermatozoa Sexing dan Perkembangan Awal Embrio
           Secara In Vitro pada Sapi

    • Authors: Alvien Nur Aini, Mohamad Agus Setiadi, Ni Wayan Kurniani Karja
      Pages: 225 - 232
      Abstract: The aim of the present study was to investigate the fertilization ability of bovine oocytes and early bovine embryonic development in vitro, fertilized by frozen X and Y sperm separated by bovine serum albumin (BSA) gradient column. Oocytes were collected from slaughter house ovarian by flushing and slicing technique. Oocytes were than maturated in tissue culture medium (TCM) 199 supplemented with 10 IU/ml pregnant mare’s serum gonadotropin (PMSG), 10 IU/ml human chorionic gonadotropin (hCG) and 10% fetal bovine serum (FBS) for 24 h in 5% CO2 incubator 39oC. Oocytes then fertilized with three kind of different frozen spermatozoa (X,Y and unsexing spermatozoa as control) for 14 h with final concentration 2x106 spermatozoa/mL. Embryos were cultured in
      synthetic oviductal fluid (SOF) supplemented with essential and non essential amino acid and 0.3% bovine serum albumin (BSA) for 96 h. Results of the experiments revealed that there was no significant difference (P>0.05) in the
      fertilization ability (49.17%; 51.40%; 53.42%) for X, Y and control group, respectively. No significant difference (P>0.05) in the number of embryos development (47.77%; 48.25%; 54.43%) for X, Y and control group, respectively. Furthermore, only small number of embryos could pass development blockade (23.80%; 26.08%; 23.61%) for X, Y and control spermatozoa with statistically no significant difference (P>0.05). It is concluded that sexed spermatozoa separated by BSA gradient column had comparable fertilization ability with unsexing spermatozoa and had ability to supported early embryonic development.
      DOI: 10.22146/jsv.27562
      Issue No: Vol. 34, No. 2
  • Efektivitas Ekstrak Biji Kapas (Gossypium hirsutum L.) terhadap Jumlah dan
           Viabilitas Embrio Mencit (Mus musculus L.)

    • Authors: Nofri Zayani, Iman Supriatna, Mohamad Agus Setiadi
      Pages: 233 - 242
      Abstract: The cottonseed (Gossypium hirsutum L.) contained gossypol as antifertility agent. The effect of cottonseed extract treatment could be decrease and impaired follicles development were accompanied by oocytes
      damage. Damage of oocytes resulted reduction of number and viability of embryos. The objective of this study was to evaluate the effectiveness of cottonseed extract (Gossypium hirsutum L.) on the number and viability of
      mice embryo (Mus musculus L.). Doses of the cottonseed extract were used consists of 0 (control), 1.5; 2.1; and 2.7 g/kg of body weight (BW) for 24 days via the oral route. This research used 24 animals healthy of female
      DDY mice 14-15 weeks old and 30-35 g BW. Embryos were collected at day 4 of pregnancy by flushing the utery cornua. The collected embryos were cultured in vitro for 48 hours in modified phosphate buffered saline (PBS) supplemented with 10% fetal bovine serum (FBS) culture medium according to the stage of its development to observe the viability of embryos. The result showed that the cottonseed extract with doses 1.5; 2.1; and 2.7 g/kg of body weight (BW) made the number of embryos which collected in D4 of pregnancy significantly lower
      than control (P<0.05). Data from embryos culture in vitro for 48 hours decreased embryos number (P<0.05) that developed in to the expanded and hatched blastocysts. At 2.7 g/kg BW, embryos only can develop to the
      blastocysts stage. Retardation (4-8 cells) and degeneration embryos did not develop in culture
      DOI: 10.22146/jsv.27563
      Issue No: Vol. 34, No. 2
  • Isolasi dan Identifikasi Enterobacter sakazakii pada Susu Mentah dan
           Produk Susu Segar di Daerah Istimewa Yogyakarta

    • Authors: Tri Yahya Budiarso, Hutri Catur Sad Winarni
      Pages: 243 - 250
      Abstract: Enterobacter sakazakii is an opportunistic pathogen that causes infections such as necrotizing enterocolitis, bacteremia, and meningitis which, in many cases, have been associated with the consumption of powdered infant formula. Raw milk has been considered to be a potential source of contamination. The aim of
      this study was to detect and identify the presence of E. sakazakii in raw milk from local farms and fresh dairy products sold by street vendors and cafés in the Special Region of Yogyakarta. A total of 80 milk samples were cultured in Enterobacterriaceae Enrichment Broth. The cell cultures were then enumerated on Tryptone Soya Agar and Chromocult Coliform Agar. For the isolation of suspect colonies, Chromogenic Druggan-Forsythe-Iversen (DFI) Agar was used. Presumptive colonies of E.sakazakii were characterized biochemically using API
      20E and molecularly through the amplification of the 16S rRNA gene using primer pairs 16_SUNI-L/Saka-2b and ESA-1/16_SUNI-R. Based on the α-glucosidase test of DFI Agar, only 9 isolates out of the 80 samples were
      identified as suspected E.sakazakii. Biochemical and molecular identification suggested that 5 isolates resulted positive for E.sakazakii, while the other 4 were Panthoea spp1.
      DOI: 10.22146/jsv.27565
      Issue No: Vol. 34, No. 2
  • Kinerja Anak Kambing Bligon Setelah Introduksi Pejantan Unggul di Kelompok
           Ternak Purwo Manunggal, Gunungkidul

    • Authors: Tri Satya Mastuti Widi, Endang Baliarti, Febri Ariyanti, Nono Ngadiono, I Gede Suparta Budisatria, Panjono Panjono, Muhamad Danang Eko Yulianto
      Pages: 251 - 258
      Abstract: Goats have become increasingly popular among smallholder mixed-crop-livestock farmers, such as in Gunungkidul District. Farmers in this district have good access to the market. However, farmers keep local breed,
      Bligon, without any improvement within breed. This study was started by introducing superior bucks to local does and aimed to evaluate the productivity of their progenies. Nineteenth kids, resulted from mating of local does and
      local bucks and 28 kids, resulted from mating of local does and superior Ettawa crossbred bucks were used in this study. Birth and weaning weights, average daily gain and body size of pre-weaning kids were measured. Birth and
      weaning weights of pre-weaning crossbred kids tended to be higher than local those of local kids but not significantly different. The average daily gain of crossbred kids were significantly higher than local kids. Body sizes in
      terms of girth of chest (GC), height at the wither (HW) and length of the body (LB) of crossbreed kids were significantly higher than those of local kids. Productivity of pre-weaning kids in the preliminary phase of the introduction
      of superior bucks were highly varied. Continuous improvement of breeding system is then needed. Introduction of superior bucks has to be supported by good keeping management.
      DOI: 10.22146/jsv.27568
      Issue No: Vol. 34, No. 2
  • Efek Protektif Andrografolid terhadap Kejadian Kardiotoksisitas Pasca
           Aplikasi Doksorubisin pada Tikus

    • Authors: Sri Wahyuni Salam, Agus Setiyono, Vetnizah Juniantito
      Pages: 259 - 266
      Abstract: Cardiotoxicity is one of the important side effects of doxorubicin, an anthracycline antibiotic and chemotherapeutic drug. The aim of this study was to explore the potential protective effect of andrographolide (Andro), an anti-inflammatory and anti-oxidant agents, against cardiotoxicity induced by doxorubicin (DXR). Thirty Sprague Dawley rats (80-100 g) were divided into four groups: (a) Control (b) DXR (4 mg/kg intraperitoneally (IP) were made weekly for 4 weeks), (c) DXR+Andro20 (low dose andro; 20 mg/kg IP were
      made daily for 4 weeks, 24 h after DXR), (d) DXR+Andro100 (high dose andro; 100 mg/kg IP were made daily for 4 weeks, 24 h after DXR). Furthermore, at the end of experimental period, all rats were euthanized and hearts were removed for hispatological analyses. Hematoxylin-eosin (HE) and Masson Trichrome (MT) staining were used to observe the histomorphological alterations and fibrosis of hearts, respectively. Our results showed that andrographolide treatment (20 mg/kg) augmented the detrimental effects of DXR such as decreased body weight and heart weight, as compared with those in DXR-treated rats. Histopathologically, heart tissue from control group showed compact myocardial architecture without any noticeable lesions. Histopathological analysis from
      DXR group showed severe inflammation and fibrosis, whereas DXR+Andro20 group showed almost normal heart morphology. Andrographolide at a dosage of 100 mg/kg did not show protective effects against doxorubicin,
      and even aggravated myocardial inflammation, as compared with DXR-treated rats. These results indicate that low dose of andrographolide compromised doxorubicin-induced decreased body weight, heart inflammation, and
      DOI: 10.22146/jsv.27569
      Issue No: Vol. 34, No. 2
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Heriot-Watt University
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