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Pharmacology and Clinical Pharmacy Research
Number of Followers: 2  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2614-0020
Published by Universitas Padjadjaran Homepage  [25 journals]
  • Antibacterial Activity of Polygonum pulchrum Blume Ethanol Extract on
           Staphylococcus aureus and Escherichia coli

    • Authors: Asman Sadino, Idin Sahidin, Wahyuni Wahyuni
      Pages: 26 - 32
      Abstract: The emergence of resistant bacteria strain has become a global health concern. It encourages the exploration of potential antibacterial agents, particularly from natural sources. The aim of this study was to investigate the antibacterial activity of ethanol extract of root, stems, leaves, and flowers of Polygonum pulchrum Blume against Staphylococcus aureus and Escherichia coli, through disc diffusion method using cup-plate method. Inhibition zone against S. aureus from roots, stems, leaves, and flowers ethanol extract were 3.5 mm, 2.5 mm, 2.25 mm, and 2.62 mm, respectively, while the inhibition zone against E. coli were 2.25 mm, 2.12 mm, 1.62 mm, and 1.75 mm, respectively. In conclusion, ethanol extract of root, stem, leaves, and flower of P. pulchrum Bl possessed weak antibacterial activity against S. aureus and E. coli.Keywords: P. pulchrum Bl, antibacterial, E. coli, S. aureus, cup-plate technique
      PubDate: 2018-08-01
      Issue No: Vol. 3, No. 2 (2018)
  • Performance Evaluation of Four Activated Partial Thromboplastin Time

    • Authors: Peppi Z. Yuzaqi, Eli Halimah, Tatat Noviani
      Pages: 33 - 40
      Abstract: Activated Partial Thromboplastin Time (APTT) is a hematological examination to identify hemostatic abnormalities. This study aimed to compare the performance evaluation of four APTT reagents, i.e., CK Prest, Pathromtin SL, Actin SL, and Cephascreen. The methods used were photo optical, percent detection, and viscosity-based detection system (VDS). The analysis was performed on blood specimen of 43 subjects. The results indicated that the accuracy and precision in normal plasma control using C. K. Prest reagent in Coag-A-Mate® MTX II were d% -0.605 and CV% 2.252%, Pathromtin SL reagent in CA 560® (Sysmex®) were d% 6.9345 and CV%1.687, Actin FSL reagent in CA 560® (Sysmex®) were d% -1.51 and CV% 1.74, and Cephascreeen reagent in STA Compact® were d% 10.81 and CV% 1.60. The accuracy and precision in pathological plasma control using Pathromtin SL reagent in CA 560® (Sysmex®) were d% -1,11 and CV% 8.82, Cephascreen reagent in STA Compact® were d% 4.64 and CV% 2.72. The coefficient of correlation between C. K. Prest reagent and Pathromtin SL reagent was 0.880 with the regresion equation y=2.31x–33.70. The coefficient of correlation between C. K. Prest reagent and Actin FSL reagent was 0.986 with the regretion equation y=0.78x+2.93. The coefficient of correlation between C. K. Prest reagent and Cephascreen reagent was 0.987 with the regretion equation y=1.70x–3.97. In conclusion, the best precision was obtained from Cephascreen reagents in STA compact®devices for both normal and pathologic control plasma, with eligible accuracy.Keywords : Activated Partial Thromboplastin Time (APTT), Photo-optical, Viscosity-based Detection System (VDS)
      PubDate: 2018-08-01
      Issue No: Vol. 3, No. 2 (2018)
  • Synthesis of Silver Nanoparticles from Cucumis melo L. and Assessment of
           Its Antimicrobial Properties

    • Authors: Yuli Haryani, Iswatun Nabella, Yuharmen Yuharmen, Ganis F. Kartika
      Pages: 46 - 50
      Abstract: Over the past decade, the use of biological agents such as plants, cyanobacteria, bacteria, and fungi for synthesis of metal nanoparticles has been developed. The aim of this study was to investigate antibacterial activity of Cucumis melo L. peel extract and its nanoparticles formulation against Eschericia coli. The nanoparticles were made using silver nitrate with the ratio between C. melo L. extract and silver nitrate aqueous solution (1 mM) were 1:10 and 1:15. The formation of silver nanoparticles was observed after microwaved for 30, 60, 90, 120, 150, and 180 seconds by visible spectrophotometry analysis. Phytochemical screening revealed the presence of flavonoid and terpenoid within the extract. However, the characteristic of surface plasmon resonance band, which occurs in the range of 410-500 nm were not found in the nanoparticle extract, even though the reaction time was extended to 330s. Antibacterial activity against E. coli of the extract and its nanoparticle formulations was determined using Resazurin microtiter assay and compared to Amoxsan® as positive control. The highest E. coli inhibition was exhibited by the nanoparticles (79.8739±0.3859), followed by the extract (65.2821±0.9949). The nanoparticles and the extract have potent antibacterial activity compared to positive control (84.5519 ± 0.2544). In conclusion, the antibacterial activity of the C. melo L. silver nanoparticles formulation was better than its extract.Keywords: Cucumis melo, silver nanoparticles, UV-Vis spectra
      PubDate: 2018-08-01
      Issue No: Vol. 3, No. 2 (2018)
  • Hypoglicemia Risk Factors on Hospitalized Type 2 Diabetes Mellitus

    • Authors: Meilani Jayanti, Keri Lestari, Rizky Abdulah
      Pages: 51 - 56
      Abstract: Hypoglycemia is one of the most important complications of diabetes treatment and it becomes an obstacle in hypoglycemia medication. Besides, hypoglycemia can cause nerve damage and impaired cognitive function so that it influences the patients mortality, morbidity, and quality of life. Recognition of hypoglycemia risk factors, blood glucose monitoring, selection of appropriate regimens and educational programs for healthcare professionals and patients with diabetes are the major issues to maintain good glycemic control, minimize the risk of hypoglycemia, and prevent long-term complications. This research employs retrospective method and the design of the research is case control.  The sample of this research is 72 patients with type 2 diabetes which is divided into two groups.  The first group is case and It consists of 23 patients (31,9%) getting hypoglycemia. Then, the second group is control and it consists of 49 patients (68,1%). In the second group the 49 patients do not get hypoglycemia and they do not receive any hypoglycemia medication in the hospital. The Results of multivariate logistic regression analysis shows that there is a significant different between the variables reduction in food intake (p 0,011) and lower laboratory result of HbA1C (p 0,003) on the incidence of hypoglycemic, where the variable reduction in food intake has the strong relationship with most major hypoglycemic (OR 9,329). On the other hand, other variables such as the use of antidiabetic drugs, diabetes duration, age, comorbidities and polypharmacy showed no significant association with hypoglycemic events. Thus, the hypoglycemic risk factors in patients with type 2 diabetes receiving antidiabetic therapy due to reduction in food intake and lower laboratory results of HbA1C. Patients with reduction in food intake at risk of hypoglycemic events nine times greater than patients with normal food intake. Keywords: type 2 diabetes mellitus, hypoglycemia, food intake, HbA1C
      PubDate: 2018-08-01
      Issue No: Vol. 3, No. 2 (2018)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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