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Publisher: Elsevier   (Total: 3031 journals)

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Showing 1 - 200 of 3031 Journals sorted alphabetically
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 20, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 16, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 79, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 22, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 27, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 4)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 5, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 302, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 3)
Acta Biomaterialia     Hybrid Journal   (Followers: 25, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription  
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 195, SJR: 3.683, h-index: 202)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.615, h-index: 21)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 9, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription   (Followers: 1)
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 3, SJR: 0.311, h-index: 16)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 2)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 21, SJR: 1.365, h-index: 73)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 5, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 4)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.383, h-index: 19)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 2)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 5, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 4, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 4)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 5)
Additive Manufacturing     Hybrid Journal   (Followers: 7, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 20)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 119, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 16, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 8, SJR: 0.299, h-index: 15)
Advances in Agronomy     Full-text available via subscription   (Followers: 15, SJR: 2.071, h-index: 82)
Advances in Anesthesia     Full-text available via subscription   (Followers: 24, SJR: 0.169, h-index: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 3)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 6, SJR: 1.054, h-index: 35)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 10, SJR: 0.801, h-index: 26)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 21, SJR: 1.286, h-index: 49)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
Advances in Botanical Research     Full-text available via subscription   (Followers: 3, SJR: 0.619, h-index: 48)
Advances in Cancer Research     Full-text available via subscription   (Followers: 26, SJR: 2.215, h-index: 78)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 0.9, h-index: 30)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 2.139, h-index: 42)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 24, SJR: 0.183, h-index: 23)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 8, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 16, SJR: 0.223, h-index: 22)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 11)
Advances in Digestive Medicine     Open Access   (Followers: 4)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Ecological Research     Full-text available via subscription   (Followers: 39, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 25, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 7)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 38, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 3)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 41, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 14)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 18, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.497, h-index: 31)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 22)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 33, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 3, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 4)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 4)
Advances in Life Course Research     Hybrid Journal   (Followers: 7, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 8)
Advances in Marine Biology     Full-text available via subscription   (Followers: 16, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 5, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 21)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 10)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 6, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 3)
Advances in Oncobiology     Full-text available via subscription   (Followers: 3)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 20, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 14)
Advances in Pharmacology     Full-text available via subscription   (Followers: 13, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 7, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 4)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 17, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 56)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 1, SJR: 0.1, h-index: 2)
Advances in Space Research     Full-text available via subscription   (Followers: 332, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 7)
Advances in Surgery     Full-text available via subscription   (Followers: 6, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 28, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 14)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 12)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 42, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 5, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 303, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 4, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 7, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 389, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 29, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 36, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access  
Agriculture and Natural Resources     Open Access   (Followers: 1)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 48, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 3, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 9, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 5)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access  
Algal Research     Partially Free   (Followers: 7, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 5, SJR: 0.776, h-index: 35)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 6, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 45, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 5)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 3)
American Heart J.     Hybrid Journal   (Followers: 45, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 47, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 34, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 6, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 32, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 25, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 31, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 48, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 173, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 51, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 2)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 22, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 23, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 21, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 32, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 13, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 5)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 52, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 3)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 2, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 38, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 152, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 7, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 10)
Anesthésie & Réanimation     Full-text available via subscription  
Anesthesiology Clinics     Full-text available via subscription   (Followers: 21, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access  
Animal Behaviour     Hybrid Journal   (Followers: 141, SJR: 1.907, h-index: 126)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 5, SJR: 1.151, h-index: 83)
Animal Reproduction Science     Hybrid Journal   (Followers: 5, SJR: 0.711, h-index: 78)
Annales d'Endocrinologie     Full-text available via subscription   (SJR: 0.394, h-index: 30)
Annales d'Urologie     Full-text available via subscription  
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (SJR: 0.177, h-index: 13)
Annales de Chirurgie de la Main et du Membre Supérieur     Full-text available via subscription  
Annales de Chirurgie Plastique Esthétique     Full-text available via subscription   (Followers: 2, SJR: 0.354, h-index: 22)
Annales de Chirurgie Vasculaire     Full-text available via subscription   (Followers: 1)

        1 2 3 4 5 6 7 8 | Last   [Sort by number of followers]   [Restore default list]

Journal Cover Alcohol
  [SJR: 0.922]   [H-I: 66]   [9 followers]  Follow
    
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 0741-8329
   Published by Elsevier Homepage  [3031 journals]
  • Phosphatidylethanol as a biomarker to identify patients with alcohol
           misuse
    • Authors: M. Afshar; E.L. Burnham; E.J. Kovacs; R.S. Cooper; M. Yong; J. Gaydos; B.J. Clark; E.M. Lowery
      First page: 70
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): M. Afshar, E.L. Burnham, E.J. Kovacs, R.S. Cooper, M. Yong, J. Gaydos, B.J. Clark, E.M. Lowery


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.013
      Issue No: Vol. 59 (2017)
       
  • Chronic ethanol consumption disrupts intestinal microbiota and mucosal
           gene expression
    • Authors: T. Barr; S. Sureshchandra; P. Ruegger; J. Borneman; K. Grant; I. Messaoudi
      First page: 70
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): T. Barr, S. Sureshchandra, P. Ruegger, J. Borneman, K. Grant, I. Messaoudi


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.015
      Issue No: Vol. 59 (2017)
       
  • The effects of alcohol and cannabis abuse on TLR expression in airway
           epithelium
    • Authors: K. Bailey; D. Katafiasz; E.L. Burnham
      Pages: 70 - 71
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): K. Bailey, D. Katafiasz, E.L. Burnham


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.016
      Issue No: Vol. 59 (2017)
       
  • Alcohol intoxication accelerates aging: Assessment of biomarkers of
           healthy aging in alcohol consumers
    • Authors: L.A. Boule; J. Gaydos; E.L. Burnham; E.J. Kovacs
      First page: 71
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): L.A. Boule, J. Gaydos, E.L. Burnham, E.J. Kovacs


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.017
      Issue No: Vol. 59 (2017)
       
  • Alcohol exacerbates an ulcerative colitis flare period
    • Authors: A.R. Cannon; A.M. Hammer; N.L. Morris; R.C. Gagnon; P. Kuprys; X. Li; M.A. Choudhry
      First page: 71
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): A.R. Cannon, A.M. Hammer, N.L. Morris, R.C. Gagnon, P. Kuprys, X. Li, M.A. Choudhry


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.018
      Issue No: Vol. 59 (2017)
       
  • Long-term alcohol exposure impairs allogeneic heterotopic heart transplant
           rejection in a mouse model
    • Authors: T. Cisneros; X. Qu; D. Dillard; C. Esquivel; S. Krams; O. Martinez
      Pages: 71 - 72
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): T. Cisneros, X. Qu, D. Dillard, C. Esquivel, S. Krams, O. Martinez


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.019
      Issue No: Vol. 59 (2017)
       
  • Alcohol, brain neuroimmune/inflammatory signaling, and neurodamage
    • Authors: M.A. Collins; N. Tajuddin; E.J. Neafsey; H.-Y. Kim
      First page: 72
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): M.A. Collins, N. Tajuddin, E.J. Neafsey, H.-Y. Kim


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.020
      Issue No: Vol. 59 (2017)
       
  • Butyrate protects intestinal immune response during chronic-binge ethanol
           exposure
    • Authors: G.A. Cresci; B. Glueck; L.E. Nagy
      First page: 72
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): G.A. Cresci, B. Glueck, L.E. Nagy


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.021
      Issue No: Vol. 59 (2017)
       
  • Alcohol intoxication and advanced age impair the pulmonary inflammatory
           response to infection
    • Authors: B.J. Curtis; J.M. Albright; D.M. Boe; E.J. Kovacs
      First page: 72
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): B.J. Curtis, J.M. Albright, D.M. Boe, E.J. Kovacs


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.022
      Issue No: Vol. 59 (2017)
       
  • Mechanistic role of Per2 and PPAR-gamma in ethanol mediated
           hyperpermeability
    • Authors: B.T. Davis; M. Shaikh; C.B. Forsyth; A. Keshavarzian
      Pages: 72 - 73
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): B.T. Davis, M. Shaikh, C.B. Forsyth, A. Keshavarzian


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.023
      Issue No: Vol. 59 (2017)
       
  • PPAR-γ agonists suppress neuroinflammation in a FASD animal model
    • Authors: P.D. Drew; J.C. Douglas; J.W. Johnson; K.D. Phelan; C.J.M. Kane
      First page: 73
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): P.D. Drew, J.C. Douglas, J.W. Johnson, K.D. Phelan, C.J.M. Kane


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.024
      Issue No: Vol. 59 (2017)
       
  • IL-18 inhibition protects intestines from excessive inflammation
           independent of IL-22 administration following alcohol and burn injury
    • Authors: A.M. Hammer; N.L. Morris; A.R. Cannon; R.C. Gagnon; P.V. Kuprys; X. Li; M.A. Choudhry
      First page: 73
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): A.M. Hammer, N.L. Morris, A.R. Cannon, R.C. Gagnon, P.V. Kuprys, X. Li, M.A. Choudhry


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.025
      Issue No: Vol. 59 (2017)
       
  • PX-478 prevents gut inflammation and normalizes the expression of tight
           junction proteins following ethanol and burn injury
    • Authors: N.L. Morris; A.M. Hammer; A.R. Cannon; R. Gagnon; X. Li; M.A. Choudhry
      Pages: 73 - 74
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): N.L. Morris, A.M. Hammer, A.R. Cannon, R. Gagnon, X. Li, M.A. Choudhry


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.026
      Issue No: Vol. 59 (2017)
       
  • Acute alcohol intoxication combined with burn injury alters the HSP-27
           level in mouse hepatocytes
    • Authors: T. Murungi; A.C. Azim
      First page: 74
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): T. Murungi, A.C. Azim


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.027
      Issue No: Vol. 59 (2017)
       
  • Histone H4 modification landscape due to chronic alcohol treatment in
           human monocyte-derived dendritic cells (MDDCs)
    • Authors: T. Parira; G. Figueroa; A. Laverde; G. Casteleiro; M. Agudelo
      First page: 74
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): T. Parira, G. Figueroa, A. Laverde, G. Casteleiro, M. Agudelo


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.028
      Issue No: Vol. 59 (2017)
       
  • Oxidation of airway cilia localized protein phosphatase 1 drives
           alcohol-induced ciliary dysfunction
    • Authors: M.E. Price; A.J. Case; M.C. Zimmerman; T.A. Wyatt; J.H. Sisson
      First page: 74
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): M.E. Price, A.J. Case, M.C. Zimmerman, T.A. Wyatt, J.H. Sisson


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.029
      Issue No: Vol. 59 (2017)
       
  • Alcohol activates FoxO-specific signaling in mesenchymal stem cells:
           Implications for MSC osteo-chondrodifferentiation
    • Authors: P.M. Roper; P. Abbasnia; J.J. Callaci
      First page: 75
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): P.M. Roper, P. Abbasnia, J.J. Callaci


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.030
      Issue No: Vol. 59 (2017)
       
  • Analysis of the respiratory tract microbial biogeography in alcohol use
           disorder populations
    • Authors: D.R. Samuelson; E.L. Burnham; V.J. Maffei; W. Vandivier; E.E. Blanchard; J.E. Shellito; M. Luo; C.M. Taylor; D.A. Welsh
      First page: 75
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): D.R. Samuelson, E.L. Burnham, V.J. Maffei, W. Vandivier, E.E. Blanchard, J.E. Shellito, M. Luo, C.M. Taylor, D.A. Welsh


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.031
      Issue No: Vol. 59 (2017)
       
  • Potential role of mucosal inflammation and histone modifications in
           alcohol-mediated promotion of colonic tumorigenesis in mice
    • Authors: P.K. Shukla; K.K. Chaudhry; H. Mir; R. Gangwar; N. Yadav; B. Manda; A.S. Meena; R.K. Rao
      Pages: 75 - 76
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): P.K. Shukla, K.K. Chaudhry, H. Mir, R. Gangwar, N. Yadav, B. Manda, A.S. Meena, R.K. Rao


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.033
      Issue No: Vol. 59 (2017)
       
  • Chronic ethanol consumption alters monocyte transcriptional program by
           modifying chromatin accessibility
    • Authors: S. Sureshchandra; M. Rais; C. Stull; K. Grant; I. Messaoudi
      First page: 76
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): S. Sureshchandra, M. Rais, C. Stull, K. Grant, I. Messaoudi


      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2016.10.034
      Issue No: Vol. 59 (2017)
       
  • Dopamine synthesis in alcohol drinking-prone and -resistant mouse strains
    • Authors: Cody A. Siciliano; Jason L. Locke; Tiffany A. Mathews; Marcelo F. Lopez; Howard C. Becker; Sara R. Jones
      Pages: 25 - 32
      Abstract: Publication date: February 2017
      Source:Alcohol, Volume 58
      Author(s): Cody A. Siciliano, Jason L. Locke, Tiffany A. Mathews, Marcelo F. Lopez, Howard C. Becker, Sara R. Jones
      Alcoholism is a prevalent and debilitating neuropsychiatric disease, and much effort has been aimed at elucidating the neurobiological mechanisms underlying maladaptive alcohol drinking in an effort to design rational treatment strategies. In preclinical literature, the use of inbred mouse lines has allowed for the examination of ethanol effects across vulnerable and resistant phenotypes. C57BL/6J mice consistently show higher rates of ethanol drinking compared to most mouse strains. Conversely, DBA/2J mice display low rates of ethanol consumption. Given that the reinforcing and rewarding effects of ethanol are thought to be in part mediated by its actions on dopamine neurotransmission, we hypothesized that alcohol-preferring C57BL/6J and alcohol-avoiding DBA/2J mice would display basal differences in dopamine system function. By administering an L-aromatic acid decarboxylase inhibitor and measuring L-Dopa accumulation via high-performance liquid chromatography as a measure of tyrosine hydroxylase activity, we found no difference in dopamine synthesis between mouse strains in the midbrain, dorsal striatum, or ventral striatum. However, we did find that quinpirole-induced inhibition of dopamine synthesis was greater in the ventral striatum of C57BL/6J mice, suggesting increased presynaptic D2-type dopamine autoreceptor sensitivity. To determine whether dopamine synthesis or autoreceptor sensitivity was altered by a history of ethanol, we exposed C57BL/6J mice to one or two weekly cycles of chronic intermittent ethanol (CIE) exposure and withdrawal. We found that there was an attenuation of baseline dopamine synthesis in the ventral striatum after two cycles of CIE. Finally, we examined tissue content of dopamine and dopamine metabolites across recombinant inbred mice bred from a C57BL/6J × DBA/2J cross (BXD). We found that low dopaminergic activity, as indicated by high dopamine/metabolite ratios, was positively correlated with drinking. Together, these findings show differential autoreceptor effects on dopamine synthesis between C57BL/6J and DBA/2J mice, and suggest that decreased dopaminergic activity is associated with excessive drinking.

      PubDate: 2017-01-22T22:01:05Z
      DOI: 10.1016/j.alcohol.2016.05.005
      Issue No: Vol. 58 (2017)
       
  • Differential potassium channel gene regulation in BXD mice reveals novel
           targets for pharmacogenetic therapies to reduce heavy alcohol drinking
    • Authors: Jennifer A. Rinker; Diana B. Fulmer; Heather Trantham-Davidson; Maren L. Smith; Robert W. Williams; Marcelo F. Lopez; Patrick K. Randall; L. Judson Chandler; Michael F. Miles; Howard C. Becker; Patrick J. Mulholland
      Pages: 33 - 45
      Abstract: Publication date: February 2017
      Source:Alcohol, Volume 58
      Author(s): Jennifer A. Rinker, Diana B. Fulmer, Heather Trantham-Davidson, Maren L. Smith, Robert W. Williams, Marcelo F. Lopez, Patrick K. Randall, L. Judson Chandler, Michael F. Miles, Howard C. Becker, Patrick J. Mulholland
      Alcohol (ethanol) dependence is a chronic relapsing brain disorder partially influenced by genetics and characterized by an inability to regulate harmful levels of drinking. Emerging evidence has linked genes that encode KV7, KIR, and KCa2 K+ channels with variation in alcohol-related behaviors in rodents and humans. This led us to experimentally test relations between K+ channel genes and escalation of drinking in a chronic-intermittent ethanol (CIE) exposure model of dependence in BXD recombinant inbred strains of mice. Transcript levels for K+ channel genes in the prefrontal cortex (PFC) and nucleus accumbens (NAc) covary with voluntary ethanol drinking in a non-dependent cohort. Transcripts that encode KV7 channels covary negatively with drinking in non-dependent BXD strains. Using a pharmacological approach to validate the genetic findings, C57BL/6J mice were allowed intermittent access to ethanol to establish baseline consumption before they were treated with retigabine, an FDA-approved KV7 channel positive modulator. Systemic administration significantly reduced drinking, and consistent with previous evidence, retigabine was more effective at reducing voluntary consumption in high-drinking than low-drinking subjects. We evaluated the specific K+ channel genes that were most sensitive to CIE exposure and identified a gene subset in the NAc and PFC that were dysregulated in the alcohol-dependent BXD cohort. CIE-induced modulation of nine genes in the NAc and six genes in the PFC covaried well with the changes in drinking induced by ethanol dependence. Here we identified novel candidate genes in the NAc and PFC that are regulated by ethanol dependence and correlate with voluntary drinking in non-dependent and dependent BXD mice. The findings that Kcnq expression correlates with drinking and that retigabine reduces consumption suggest that KV7 channels could be pharmacogenetic targets to treat individuals with alcohol addiction.

      PubDate: 2017-01-22T22:01:05Z
      DOI: 10.1016/j.alcohol.2016.05.007
      Issue No: Vol. 58 (2017)
       
  • Reduced ethanol drinking following selective cortical interneuron deletion
           of the GluN2B NMDA receptors subunit
    • Authors: Anna K. Radke; Nicholas J. Jury; Eric Delpire; Kazu Nakazawa; Andrew Holmes
      Pages: 47 - 51
      Abstract: Publication date: February 2017
      Source:Alcohol, Volume 58
      Author(s): Anna K. Radke, Nicholas J. Jury, Eric Delpire, Kazu Nakazawa, Andrew Holmes
      N-Methyl-d-aspartate receptors (NMDAR) are involved in the regulation of alcohol drinking, but the contribution of NMDAR subunits located on specific neuronal populations remains incompletely understood. The current study examined the role of GluN2B-containing NMDARs expressed on cortical principal neurons and cortical interneurons in mouse ethanol drinking. Consumption of escalating concentrations of ethanol was measured in mice with GluN2B gene deletion in either cortical principal neurons (GluN2BCxNULL) or interneurons (GluN2BInterNULL), using a two-bottle choice paradigm. Results showed that GluN2BInterNULL, but not GluN2BCxNULL, mice consumed significantly less ethanol, at relatively high concentrations, than non-mutant controls. In a second paradigm in which mice were offered a 15% ethanol concentration, without escalation, GluN2BCxNULL mice were again no different from controls. These findings provide novel evidence for a contribution of interneuronal GluN2B-containing NMDARs in the regulation of ethanol drinking.
      Graphical abstract image

      PubDate: 2017-01-22T22:01:05Z
      DOI: 10.1016/j.alcohol.2016.07.005
      Issue No: Vol. 58 (2017)
       
  • Sex differences in the behavioral sequelae of chronic ethanol exposure
    • Authors: Nicholas J. Jury; Jeffrey F. DiBerto; Thomas L. Kash; Andrew Holmes
      Pages: 53 - 60
      Abstract: Publication date: February 2017
      Source:Alcohol, Volume 58
      Author(s): Nicholas J. Jury, Jeffrey F. DiBerto, Thomas L. Kash, Andrew Holmes
      Rates of alcohol use disorders (AUDs) differ between men and women, and there is also marked variation between sexes in the effects of acute and chronic alcohol. In parallel to observations in humans, prior studies in rodents have described male/female differences across a range of ethanol-related behaviors, including ethanol drinking. Nonetheless, there remain gaps in our knowledge of the role of sex in moderating the effects of ethanol, particularly in models of chronic ethanol exposure. The goal of the current study was to assess various behavioral sequelae of exposing female C57BL/6J mice to chronic intermittent ethanol (CIE) via ethanol vapors. Following four weeks of CIE exposure, adult male and female mice were compared for ethanol drinking in a two-bottle paradigm, for sensitivity to acute ethanol intoxication (via loss of righting reflex [LORR]) and for anxiety-like behaviors in the novelty-suppressed feeding and marble burying assays. Next, adult and adolescent females were tested on two different two-bottle drinking preparations (fixed or escalating ethanol concentration) after CIE. Results showed that males and females exhibited significantly blunted ethanol-induced LORR following CIE, whereas only males showed increased anxiety-like behavior after CIE. Increased ethanol drinking after CIE was also specific to males, but high baseline drinking in females may have occluded detection of a CIE-induced effect. The failure to observe elevated drinking in females in response to CIE was also seen in females exposed to CIE during adolescence, regardless of whether a fixed or escalating ethanol-concentration two-bottle procedure was employed. Collectively, these data add to the literature on sex differences in ethanol-related behaviors and provide a foundation for future studies examining how the neural consequences of CIE might differ between males and females.

      PubDate: 2017-01-22T22:01:05Z
      DOI: 10.1016/j.alcohol.2016.07.007
      Issue No: Vol. 58 (2017)
       
  • Binge alcohol alters PNPLA3 levels in liver through epigenetic mechanism
           involving histone H3 acetylation
    • Authors: Ricardo J. Restrepo; Robert W. Lim; Ronald J. Korthuis; Shivendra D. Shukla
      Abstract: Publication date: Available online 12 March 2017
      Source:Alcohol
      Author(s): Ricardo J. Restrepo, Robert W. Lim, Ronald J. Korthuis, Shivendra D. Shukla
      The human PNPLA3 (patatin-like phospholipase domain-containing 3) gene codes for a protein which is highly expressed in adipose tissue and liver, and is implicated in lipid homeostasis. While PNPLA3 protein contains regions homologous to functional lipolytic proteins, the regulation of its tissue expression is reflective of lipogenic genes. A naturally occurring genetic variant of PNPLA3 in humans has been linked to increased susceptibility to alcoholic liver disease. We have examined the modulatory effect of alcohol on PNPLA3 protein and mRNA expression as well as the association of its gene promoter with acetylated histone H3K9 by chromatin immunoprecipitation (ChIP) assay in rat hepatocytes in vitro, and in vivo in mouse and rat models of acute binge, chronic, and chronic followed by acute binge ethanol administration. Protein expression of PNPLA3 was significantly increased by alcohol in all three models used. PNPLA3 mRNA also increased, albeit to a varying degree. ChIP assay using H3AcK9 antibody showed increased association with the promoter of PNPLA3 in hepatocytes and in mouse liver. This was less evident in rat livers in vivo except under chronic treatment. It is concluded for the first time that histone acetylation plays a role in the modulation of PNPLA3 levels in the liver exposed to binge ethanol both in vitro and in vivo.

      PubDate: 2017-03-12T22:40:46Z
      DOI: 10.1016/j.alcohol.2017.01.009
       
  • Mechanistic insights into epigenetic modulation of ethanol consumption
    • Authors: Igor Ponomarev; Claire E. Stelly; Hitoshi Morikawa; Yuri A. Blednov; R. Dayne Mayfield; R. Adron Harris
      Abstract: Publication date: Available online 12 March 2017
      Source:Alcohol
      Author(s): Igor Ponomarev, Claire E. Stelly, Hitoshi Morikawa, Yuri A. Blednov, R. Dayne Mayfield, R. Adron Harris
      There is growing evidence that small-molecule inhibitors of epigenetic modulators, such as histone deacetylases (HDAC) and DNA methyltransferases (DNMT), can reduce voluntary ethanol consumption in animal models, but molecular and cellular processes underlying this behavioral effect are poorly understood. We used C57BL/6J male mice to investigate the effects of two FDA-approved drugs, decitabine (a DNMT inhibitor) and SAHA (an HDAC inhibitor), on ethanol consumption using two tests: binge-like drinking in the dark (DID) and chronic intermittent every other day (EOD) drinking. Decitabine but not SAHA reduced ethanol consumption in both tests. We further investigated decitabine's effects on the brain's reward pathway by gene expression profiling in the ventral tegmental area (VTA), using RNA sequencing and electrophysiological recordings from VTA dopaminergic neurons. Decitabine-induced decreases in EOD drinking were associated with global changes in gene expression, implicating regulation of cerebral blood flow, extracellular matrix organization, and neuroimmune functions in decitabine actions. In addition, an in vivo administration of decitabine shortened ethanol-induced excitation of VTA dopaminergic neurons in vitro, suggesting that decitabine reduces ethanol drinking via changes in the reward pathway. Taken together, our data suggest a contribution of both neuronal and non-neuronal mechanisms in the VTA in the regulation of ethanol consumption. Decitabine and other epigenetic compounds have been approved for cancer treatment, and understanding their mechanisms of actions in the brain may assist in repurposing these drugs and developing novel therapies for central disorders, including drug addiction.

      PubDate: 2017-03-12T22:40:46Z
      DOI: 10.1016/j.alcohol.2017.01.016
       
  • Epigenetic mediators and consequences of excessive alcohol consumption
    • Authors: Amanda H. Mahnke; Rajesh C. Miranda; Gregg E. Homanics
      Abstract: Publication date: Available online 11 March 2017
      Source:Alcohol
      Author(s): Amanda H. Mahnke, Rajesh C. Miranda, Gregg E. Homanics


      PubDate: 2017-03-12T22:40:46Z
      DOI: 10.1016/j.alcohol.2017.02.357
       
  • Alcohol effects on the epigenome in the germline: Role in the inheritance
           of alcohol-related pathology
    • Authors: Lucy G. Chastain; Dipak K. Sarkar
      Abstract: Publication date: Available online 6 March 2017
      Source:Alcohol
      Author(s): Lucy G. Chastain, Dipak K. Sarkar
      Excessive alcohol exposure has severe health consequences, and clinical and animal studies have demonstrated that disruptions in the epigenome of somatic cells, such as those in brain, are an important factor in the development of alcohol-related pathologies, such as alcohol-use disorders (AUDs) and fetal alcohol spectrum disorders (FASDs). It is also well known that alcohol-related health problems are passed down across generations in human populations, but the complete mechanisms for this phenomenon are currently unknown. Recent studies in animal models have suggested that epigenetic factors are also responsible for the transmission of alcohol-related pathologies across generations. Alcohol exposure has been shown to induce changes in the epigenome of sperm of exposed male animals, and these epimutations are inherited in the offspring. This paper reviews evidence for multigenerational and transgenerational epigenetic inheritance of alcohol-related pathology through the germline. We also review the literature on the epigenetic effects of alcohol exposure on somatic cells in brain, and its contribution to AUDs and FASDs. We note gaps in knowledge in this field, such as the lack of clinical studies in human populations and the lack of data on epigenetic inheritance via the female germline, and we suggest future research directions.

      PubDate: 2017-03-10T22:27:30Z
      DOI: 10.1016/j.alcohol.2016.12.007
       
  • Epigenetic mechanisms of alcoholism and stress-related disorders
    • Authors: Martina Palmisano; Subhash C. Pandey
      Abstract: Publication date: Available online 3 March 2017
      Source:Alcohol
      Author(s): Martina Palmisano, Subhash C. Pandey
      Stress-related disorders, such as anxiety, early life stress, and posttraumatic stress disorder appear to be important factors in promoting alcoholism, as alcohol consumption can temporarily attenuate the negative affective symptoms of these disorders. Several molecules involved in signaling pathways may contribute to the neuroadaptation induced during alcohol dependence and stress disorders, and among these, brain-derived neurotrophic factor (BDNF), corticotropin releasing factor (CRF), neuropeptide Y (NPY) and opioid peptides (i.e., nociceptin and dynorphin) are involved in the interaction of stress and alcohol. In fact, alterations in the expression and function of these molecules have been associated with the pathophysiology of stress-related disorders and alcoholism. In recent years, various studies have focused on the epigenetic mechanisms that regulate chromatin architecture, thereby modifying gene expression. Interestingly, epigenetic modifications in specific brain regions have been shown to be associated with the neurobiology of psychiatric disorders, including alcoholism and stress. In particular, the enzymes responsible for chromatin remodeling (i.e., histone deacetylases and methyltransferases, DNA methyltransferases) have been identified as common molecular mechanisms for the interaction of stress and alcohol and have become promising therapeutic targets to treat or prevent alcoholism and associated emotional disorders.

      PubDate: 2017-03-04T21:46:37Z
      DOI: 10.1016/j.alcohol.2017.01.001
       
  • Alcohol induces epigenetic immunomodulation of human monocyte-derived
           dendritic cells
    • Authors: Agudelo
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): M. Agudelo


      PubDate: 2017-03-04T21:46:37Z
       
  • Mucosa-associated bacteria as a therapeutic target of alcoholic liver
           disease
    • Authors: Schnabl
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): B. Schnabl


      PubDate: 2017-03-04T21:46:37Z
       
  • Role of macrophages in alcoholic liver disease
    • Authors: Wang
      Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59
      Author(s): M. Wang, C. Ju


      PubDate: 2017-03-04T21:46:37Z
       
  • Instructions to Authors
    • Abstract: Publication date: March 2017
      Source:Alcohol, Volume 59


      PubDate: 2017-03-04T21:46:37Z
       
  • DNA Methylation program in normal and alcohol-induced thinning cortex
    • Authors: Nail Can Öztürk; Marisol Resendiz; Hakan Öztürk; Feng C. Zhou
      Abstract: Publication date: Available online 20 February 2017
      Source:Alcohol
      Author(s): Nail Can Öztürk, Marisol Resendiz, Hakan Öztürk, Feng C. Zhou
      While cerebral underdevelopment is a hallmark of fetal alcohol spectrum disorders (FASD), the mechanism(s) guiding the broad cortical neurodevelopmental deficits are not clear. DNA methylation is known to regulate early development and tissue specification through gene regulation. Here, we examined DNA methylation in the onset of alcohol-induced cortical thinning in a mouse model of FASD. C57BL/6J mice were administered a 4% alcohol (v/v) liquid diet from embryonic (E) days 7–16, and their embryos were harvested at E17, along with isocaloric liquid diet and lab chow controls. Cortical neuroanatomy, neural phenotypes, and epigenetic markers of methylation were assessed using immunohistochemistry, Western blot, and methyl-DNA assays. We report that cortical thickness, neuroepithelial proliferation, and neuronal migration and maturity were found to be deterred by alcohol at E17. Simultaneously, DNA methylation, including 5-methylcytosine (5 mC) and 5-hydroxcylmethylcytosine (5hmC), which progresses as an intrinsic program guiding normal embryonic cortical development, was severely affected by in utero alcohol exposure. The intricate relationship between cortical thinning and this DNA methylation program disruption is detailed and illustrated. DNA methylation, dynamic across the multiple cortical layers during the late embryonic stage, is highly disrupted by fetal alcohol exposure; this disruption occurs in tandem with characteristic developmental abnormalities, ranging from structural to molecular. Finally, our findings point to a significant question for future exploration: whether epigenetics guides neurodevelopment or whether developmental conditions dictate epigenetic dynamics in the context of alcohol-induced cortical teratogenesis.

      PubDate: 2017-02-26T06:10:22Z
      DOI: 10.1016/j.alcohol.2017.01.006
       
  • Alcohol drinking during adolescence increases consumptive responses to
           alcohol in adulthood in Wistar rats
    • Authors: Leslie R. Amodeo; Diana Kneiber; Derek N. Wills; Cindy L. Ehlers
      Abstract: Publication date: Available online 7 February 2017
      Source:Alcohol
      Author(s): Leslie R. Amodeo, Diana Kneiber, Derek N. Wills, Cindy L. Ehlers
      Binge drinking and the onset of alcohol-use disorders usually peak during the transition between late adolescence and early adulthood, and early adolescent onset of alcohol consumption has been demonstrated to increase the risk for alcohol dependence in adulthood. In the present study, we describe an animal model of early adolescent alcohol consumption where animals drink unsweetened and unflavored ethanol in high concentrations (20%). Using this model, we investigated the influence of drinking on alcohol-related appetitive behavior and alcohol consumption levels in early adulthood. Further, we also sought to investigate whether differences in alcohol-related drinking behaviors were specific to exposure in adolescence versus exposure in adulthood. Male Wistar rats were given a 2-bottle choice between 20% ethanol and water in one group and between two water bottles in another group during their adolescence (Postnatal Day [PD] 26–59) to model voluntary drinking in adolescent humans. As young adults (PD85), rats were trained in a paradigm that provided free access to 20% alcohol for 25 min after completing up to a fixed-ratio (FR) 16 lever press response. A set of young adult male Wistar rats was exposed to the same paradigm using the same time course, beginning at PD92. The results indicate that adolescent exposure to alcohol increased consumption of alcohol in adulthood. Furthermore, when investigating differences between adolescent high and low drinkers in adulthood, high consumers continued to drink more alcohol, had fewer FR failures, and faster completion of FR schedules in adulthood, whereas the low consumers were no different from controls. Rats exposed to ethanol in young adulthood also increased future intake, but there were no differences in any other components of drinking behavior. Both adolescent- and adult-exposed rats did not exhibit an increase in lever pressing during the appetitive challenge session. These data indicate that adolescent and early adult alcohol exposure can increase consumptive aspects of drinking but that adolescent exposure may preferentially influence the motivation to drink.

      PubDate: 2017-02-12T00:22:30Z
      DOI: 10.1016/j.alcohol.2016.12.002
       
  • An investigation into the effect of alcohol consumption on health status
           and health care utilization in Ireland
    • Authors: Gillian Ormond; Rosemary Murphy
      Abstract: Publication date: Available online 4 February 2017
      Source:Alcohol
      Author(s): Gillian Ormond, Rosemary Murphy
      This paper presents a study of the effect of alcohol consumption on individual health status and health care utilization in Ireland using the 2007 Slán National Health and Lifestyle Survey, while accounting for the endogenous relationship between alcohol and health. Drinkers are categorized as those who never drank, non-drinkers, moderate drinkers, or heavy drinkers, based on national recommended weekly drinking levels in Ireland. The drinking-status equation is estimated using an ordered probit model. Predicted values for the inverse mills ratio are generated, which are then included in the health and health-care utilization equations. Differences in health status for each category of drinker are examined, and the relationship between both alcohol consumption and health with a host of other personal and socio-economic variables is also identified. Given that the measure of health status available is self-assessed, the effect of alcohol consumption on health-care utilization is also analyzed as an alternative measure of health. Findings show that in Ireland, moderate drinkers enjoy the best health status. More moderate drinkers report having very good or excellent health compared with heavy drinkers, non-drinkers, or those who never drank. While heavy drinkers do not report having as good a health status as moderate drinkers, they are better off in terms of health when compared with non-drinkers and those who are lifetime abstainers.

      PubDate: 2017-02-05T23:29:51Z
      DOI: 10.1016/j.alcohol.2017.01.008
       
  • Changes to histone modifications following prenatal alcohol exposure: An
           emerging picture
    • Authors: Eric J. Chater-Diehl; Benjamin I. Laufer; Shiva M. Singh
      Abstract: Publication date: Available online 4 February 2017
      Source:Alcohol
      Author(s): Eric J. Chater-Diehl, Benjamin I. Laufer, Shiva M. Singh
      Epigenetic mechanisms are important for facilitating gene-environment interactions in many disease etiologies, including Fetal Alcohol Spectrum Disorders (FASD). Extensive research into the role of DNA methylation and miRNAs in animal models has illuminated the complex role of these mechanisms in FASD. In contrast, histone modifications have not been as well researched, due in part to being less stable than DNA methylation and less well-characterized in disease. It is now apparent that even changes in transient marks can have profound effects if they alter developmental trajectories. In addition, many histone methylations are now known to be relatively stable and can propagate themselves. As technologies and knowledge have advanced, a small group has investigated the role of histone modifications in FASD. Here, we synthesize the data on the effects of prenatal alcohol exposure (PAE) on histone modifications. Several key points are evident. AS with most alcohol-induced outcomes, timing and dosage differences yield variable effects. Nevertheless, these studies consistently find enrichment of H3K9ac, H3K27me2,3, and H3K9me2, and increased expression of histone acetyltransferases and methyltransferases. The consistency of these alterations may implicate them as key mechanisms underlying FASD. Histone modification changes do not often correlate with gene expression changes, though some important examples exist. Encouragingly, attempts to reproduce specific histone modification changes are very often successful. We comment on possible directions for future studies, focusing on further exploration of current trends, expansion of time-point and dosage regimes, and evaluation of biomarker potential.

      PubDate: 2017-02-05T23:29:51Z
      DOI: 10.1016/j.alcohol.2017.01.005
       
  • Urine methanol concentration and alcohol hangover severity
    • Authors: M. Mackus; A.J.A.E. Van de Loo; G.A.H. Korte-Bouws; R.H.P. Van Neer; X. Wang; T.T. Nguyen; K.A. Brookhuis; J. Garssen; J.C. Verster
      Abstract: Publication date: Available online 14 December 2016
      Source:Alcohol
      Author(s): M. Mackus, A.J.A.E. Van de Loo, G.A.H. Korte-Bouws, R.H.P. Van Neer, X. Wang, T.T. Nguyen, K.A. Brookhuis, J. Garssen, J.C. Verster
      Background Congeners are substances, other than ethanol, that are produced during fermentation. Previous research found that the consumption of congener rich drinks contributes to the severity of alcohol hangover. Methanol is such a congener that has been related to alcohol hangover. Therefore, the aim of this study was to examine the relationship between urine methanol concentration and alcohol hangover severity. Methods N = 36 healthy social drinkers (22 females, 14 males), aged 18–30 years old, participated in a naturalistic study, comprising a hangover day and a control day (no alcohol consumed the previous three days). N = 18 of them have regular hangovers (the hangover group), while the other N = 18 claim to be hangover immune (hangover-immune group). Overall hangover severity was assessed, and that of 23 individual hangover symptoms. Urine methanol concentration on the hangover and control day were compared, and correlated to hangover (symptom) severity. Results Urine methanol concentration was significantly higher on hangover days compared to control days (p = 0.0001). No significant differences in urine methanol concentration were found between the hangover group and hangover immune group. However, urine methanol concentration did not significantly correlate with overall hangover severity (r = −0.011, p = 0.948), nor with any of the individual hangover symptoms. These findings were observed also when analyzing the data separately for the hangover-immune group. In the hangover group, a significant correlation urine methanol concentration was found only with vomiting (r = 0.489, p = 0.037). Conclusion No significant correlation was observed between urine methanol concentration and hangover severity, nor with individual core hangover symptoms.

      PubDate: 2016-12-19T11:58:36Z
      DOI: 10.1016/j.alcohol.2016.12.004
       
  • Cognitive sequelae of methanol poisoning involve executive dysfunction and
           memory impairment in cross-sectional and long-term perspective
    • Authors: O. Bezdicek; J. Michalec; M. Vaneckova; J. Klempir; I. Liskova; Z. Seidl; B. Janikova; M. Miovsky; J. Hubacek; P. Diblik; P. Kuthan; A. Pilin; I. Kurcova; Z. Fenclova; V. Petrik; T. Navratil; D. Pelclova; S. Zakharov; E. Ruzicka
      Abstract: Publication date: Available online 10 December 2016
      Source:Alcohol
      Author(s): O. Bezdicek, J. Michalec, M. Vaneckova, J. Klempir, I. Liskova, Z. Seidl, B. Janikova, M. Miovsky, J. Hubacek, P. Diblik, P. Kuthan, A. Pilin, I. Kurcova, Z. Fenclova, V. Petrik, T. Navratil, D. Pelclova, S. Zakharov, E. Ruzicka
      Methanol poisoning leads to lesions in the basal ganglia and subcortical white matter, as well as to demyelination and atrophy of the optic nerve. However, information regarding cognitive deficits in a large methanol sample is lacking. The principal aim of the present study was to identify the cognitive sequelae of methanol poisoning and their morphological correlates. A sample of 50 patients (METH; age 48 ± 13), 3–8 months after methanol poisoning and 57 control subjects (CS; age 49 ± 13) were administered a neuropsychological battery, 46 patients were followed in two years perspective. Patients additionally underwent 1.5T magnetic resonance imaging (MRI). Three biochemical and toxicological metabolic markers and questionnaire regarding alcohol abuse facilitated the classification of 24 patients with methanol poisoning without alcohol abuse (METHna) and 22 with methanol poisoning and alcohol abuse (METHa). All groups were compared to correspondingly sized one control group, matched for age, education, premorbid intelligence level, global cognitive performance, and level of depressive symptoms. Using hierarchical multiple regression we found significant differences between METH and CS especially in executive and memory domains. METHa showed a similar pattern of cognitive impairment with generally more severe executive dysfunction. Moreover, all METH patients with extensive involvement on brain MRI (lesions in ≥2 anatomical regions) had a more severe cognitive impairment. From a longitudinal perspective, we did not find any changes in their cognitive functioning after two years follow-up. Our findings suggest that methanol poisoning is associated with executive dysfunction and explicit memory impairment, supposedly due to basal ganglia dysfunction and disruption of frontostriatal circuitry proportional to the number of brain lesions and these changes are persistent after two years follow-up.

      PubDate: 2016-12-12T11:31:46Z
      DOI: 10.1016/j.alcohol.2016.12.003
       
  • Effects of the serotonin transporter gene, sensitivity of response to
           alcohol, and parental monitoring on risk for problem alcohol use
    • Authors: Lora M. Cope; Emily C. Munier; Elisa M. Trucco; Jillian E. Hardee; Margit Burmeister; Robert A. Zucker; Mary M. Heitzeg
      Abstract: Publication date: Available online 6 December 2016
      Source:Alcohol
      Author(s): Lora M. Cope, Emily C. Munier, Elisa M. Trucco, Jillian E. Hardee, Margit Burmeister, Robert A. Zucker, Mary M. Heitzeg
      The serotonin transporter-linked polymorphic region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) has been previously associated with alcohol-related risk. Most findings point to short (S) allele carriers being at increased risk for negative alcohol outcomes relative to long allele homozygotes, although some work indicates a more complex relationship. The current prospective study aimed to clarify how and under what circumstances variations in 5-HTTLPR transmit risk for various alcohol-related outcomes. Participants were 218 adolescents and young adults (29% female) enrolled in the Michigan Longitudinal Study. We tested a moderated mediation model with 5-HTTLPR as the predictor, Self-Rating of the Effects of Alcohol (SRE) score as the mediator, alcohol-related outcomes as the dependent variables, parental monitoring as the moderator of the SRE to alcohol outcomes path, and prior drinks, sex, age, and body mass index as covariates. Four alcohol-related outcomes were tested. The S allele was associated with higher SRE scores (i.e., lower response to alcohol). Parental monitoring was a significant moderator: At low levels of parental monitoring, higher SRE scores predicted more drinks consumed and binge drinking episodes. At high levels of monitoring, higher SRE scores were significantly related to fewer alcohol-related problems. Findings suggest that one mechanism by which 5-HTTLPR variation transmits alcohol-related risk is through level of response to alcohol. Furthermore, the strength and direction of this effect varied by level of parental monitoring, indicating that even in the presence of genetic and physiological vulnerability, parents can influence the likelihood of offspring developing problematic alcohol-related behaviors.

      PubDate: 2016-12-12T11:31:46Z
      DOI: 10.1016/j.alcohol.2016.12.001
       
  • Initial subjective reward to alcohol in Sprague-Dawley rats
    • Authors: Todd B. Nentwig; Kevin P. Myers; Judith E. Grisel
      Abstract: Publication date: Available online 23 November 2016
      Source:Alcohol
      Author(s): Todd B. Nentwig, Kevin P. Myers, Judith E. Grisel
      Initial subjective response to the rewarding properties of alcohol predicts voluntary consumption and the risk for alcohol use disorders. We assessed the initial subjective reward to alcohol in rats using a single exposure conditioned place preference (SE-CPP) paradigm. Sprague-Dawley rats demonstrate preference for a context paired with a single systemic injection of ethanol (1.0 g/kg, delivered intraperitoneally). However, expression of SE-CPP in males depended on pairing ethanol with the first exposure to the conditioning apparatus and procedures, while conditioning day did not appreciably affect SE-CPP in females, consistent with the view that females experience heightened addiction vulnerability. This model offers researchers a high throughput assay for investigating factors that influence alcohol reward and may point the way toward more effective prevention and treatment efforts.

      PubDate: 2016-11-28T10:22:33Z
      DOI: 10.1016/j.alcohol.2016.11.005
       
  • Resting state synchrony in long-term abstinent alcoholics: Effects of a
           current major depressive disorder diagnosis
    • Authors: George Fein; Jazmin Camchong; Valerie A. Cardenas; Andy Stenger
      Abstract: Publication date: Available online 23 November 2016
      Source:Alcohol
      Author(s): George Fein, Jazmin Camchong, Valerie A. Cardenas, Andy Stenger
      Alcoholism is characterized by a lack of control over an impulsive and compulsive drive toward excessive alcohol consumption despite significant negative consequences; our previous work demonstrated that successful abstinence is characterized by decreased resting-state synchrony (RSS) as measured with functional magnetic resonance imaging (fMRI), within appetitive drive networks and increased RSS in emotion regulation and inhibitory executive control networks. Our hypothesis is that LTAA (Long-Term Abstinent Alcoholics) with a current major depressive disorder (MDD) drank primarily to deal with the negative affect associated with their MDD and not because of a heightened externalizing diathesis (including heightened appetitive drive), and consequently, in achieving and maintaining abstinence, such individuals would not exhibit the RSS adaptations characteristic of pure alcoholics. We studied 69 NSAC (Non Substance Abusing Controls) and 40 LTAA (8 with current MDD, 32 without a current MDD) using resting-state fMRI and seed based connectivity analyses. In the inhibitory executive control network (nucleus accumbens vs. left dorsolateral prefrontal cortex), LTAA with a current MDD showed increased synchrony compared to NSAC. In the emotion regulation executive control network (subgenual anterior cingulate cortex vs. right dorsolateral prefrontal cortex), LTAA with current MDD did not show increased RSS. In the appetitive drive networks (nucleus accumbens vs, aspects of the caudate nucleus and thalamus), LTAA with a current MDD did not show a reduction of RSS compared to NSAC, but LTAA without a current MDD did. These results suggest different pathways to their alcohol dependence in LTAA with vs. without a current MDD, and different patterns of brain activity in long-term abstinence, suggesting different treatment needs.

      PubDate: 2016-11-28T10:22:33Z
      DOI: 10.1016/j.alcohol.2016.11.008
       
  • Preface to a special issue on genetic models of alcoholism and
           alcohol-stress interactions
    • Authors: Robert W. Williams; Andrew Holmes
      Abstract: Publication date: Available online 23 November 2016
      Source:Alcohol
      Author(s): Robert W. Williams, Andrew Holmes


      PubDate: 2016-11-28T10:22:33Z
      DOI: 10.1016/j.alcohol.2016.11.010
       
  • Involvement of Wnt pathway in ethanol-induced inhibition of mouse
           embryonic stem cell differentiation
    • Authors: Qian Wang; Jing-wen Song; Yang Liu; Xian-xian Zhao
      Abstract: Publication date: Available online 16 November 2016
      Source:Alcohol
      Author(s): Qian Wang, Jing-wen Song, Yang Liu, Xian-xian Zhao
      Ethanol has been reported to have toxicity on embryonic stem cells (ESCs). The present study aims to address the teratogenic effects of ethanol on the growth and cardiac differentiation of ESCs. Mouse embryonic stem D3 cells were employed. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays were used to determine cytotoxicity. Quantitative real time polymerase chain reaction (qRT-PCR) and Western blotting were used to analyze the expressions of cardiac differentiation-related and Wnt signaling factors. The beating profile of cardiomyocytes was recorded to assess cardiac differentiation. Ethanol induced growth inhibition in both undifferentiated and differentiated ESCs after 5 days of exposure. Ethanol inhibited the loss of pluripotent gene expressions including Nanog, Sox2 and Oct4. The expressions of cardiac markers, Nkx2.5, Mef2c, Tbx5, dHand, αMHC, Cx43 and troponin C1, were suppressed by ethanol treatment. Furthermore, ethanol delayed cardiac differentiation of ESCs till 11 days of differentiation. The expressions of Wnt-related regulators, β-catenin and its target cyclin D1, were downregulated by ethanol. Wnt pathway agonist wnt3a could greatly rescue ethanol-induced inhibition of cardiac differentiation and Wnt-pathway-related protein expressions. These finding suggested that ethanol suppresses mouse ESC differentiation largely by inhibiting Wnt signaling pathway.

      PubDate: 2016-11-20T15:47:48Z
      DOI: 10.1016/j.alcohol.2016.11.006
       
  • Developmental lead exposure induces opposite effects on ethanol intake and
           locomotion in response to central vs. systemic cyanamide administration
    • Authors: Mara Soledad Mattalloni; Romina Deza-Ponzio; Paula Alejandra Albrecht; Liliana Marina Cancela; Miriam Beatriz Virgolini
      Abstract: Publication date: Available online 10 November 2016
      Source:Alcohol
      Author(s): Mara Soledad Mattalloni, Romina Deza-Ponzio, Paula Alejandra Albrecht, Liliana Marina Cancela, Miriam Beatriz Virgolini
      Lead (Pb) is a developmental neurotoxicant that elicits differential responses to drugs of abuse. Particularly, ethanol consumption has been demonstrated to be increased as a consequence of environmental Pb exposure, with catalase (CAT) and brain acetaldehyde (ACD, the first metabolite of ethanol) playing a role. The present study sought to interfere with ethanol metabolism by inhibiting ALDH2 (mitochondrial aldehyde dehydrogenase) activity in both liver and brain of control and Pb-exposed rats as a strategy to accumulate ACD, a substance that plays a major role in the drug's reinforcing and/or aversive effects. To evaluate the impact on a 2-h chronic voluntary ethanol intake test, developmentally Pb-exposed and control rats were administered with cyanamide (CY, an ALDH inhibitor) either systemically or intracerebroventricularly (i.c.v.) on the last 4 sessions of the experiment. Furthermore, on the last session and after locomotor activity was assessed, all animals were sacrificed to obtain brain and liver samples for ALDH2 and CAT activity determination. Systemic CY administration reduced the elevated ethanol intake already reported in the Pb-exposed animals (but not in the controls) accompanied by complete liver (but not brain) ALDH2 inactivation. On the other hand, a 0.3 mg i.c.v. CY administration enhanced both ethanol intake and locomotor activity accompanied by brain ALDH2 inactivation in control animals, while an increase in ethanol consumption was also observed in the Pb-exposed group, although in the absence of brain ALDH2 blockade. No changes were observed in CAT activity as a consequence of CY administration. These results support the participation of liver and brain ACD in ethanol intake and locomotor activity, responses that are modulated by developmental Pb exposure.
      Graphical abstract image

      PubDate: 2016-11-13T15:01:30Z
      DOI: 10.1016/j.alcohol.2016.11.002
       
  • Seeking mental health care from private health practitioners among
           individuals with alcohol dependence/abuse; results from a study in the
           French general population
    • Authors: Aymery Constant; William Sherlaw; Viviane Kovess-Masfety
      Abstract: Publication date: Available online 24 September 2016
      Source:Alcohol
      Author(s): Aymery Constant, William Sherlaw, Viviane Kovess-Masfety
      Introduction Better knowledge of the factors that have an impact on pathways to mental health care may contribute greatly to organizing optimum health-care delivery. However, surveillance systems concerning alcohol problems in the French general population are suboptimal. The objectives of this study were to investigate: 1) the prevalence of mental health-care seeking in individuals with alcohol abuse/dependence in France, 2) which category of medical practitioner was consulted, and 3) psychological and socio-environmental factors associated with mental health-care seeking. Methods A total sample of 22,138 individuals was interviewed in a telephone survey. Individual data on alcohol dependence/abuse and other mental health disorders were collected using the Composite International Diagnosis Interview – short form. Mental health-care seeking was assessed, together with data on living conditions, deprivation, and self-reported drinking problems. Only respondents meeting criteria for alcohol dependence/abuse were included in analyses. Results Less than half of the 722 respondents with alcohol abuse/dependence had sought mental health care in the preceding 12 months, of whom 90.5% consulted their general practitioner (GP) (56.1%), or both a general practitioner and a psychiatrist (34.4%). Mental health-care seeking was associated with female sex, previous alcohol discussion with a doctor, and the presence of psychiatric comorbidities arising in the preceding 12 months. Living environment, socio-economic status, or self-reported drinking problems had no influence. Discussion A minority of people with alcohol abuse/dependence sought mental health care, mainly in relation to psychiatric comorbidities. In addition, most people consulting a GP were not referred to a psychiatrist. However, social deprivation and living in rural areas did not hinder mental health-care seeking among respondents. Adequate protocols to treat alcohol disorders could be implemented among private health-care providers to improve management of alcohol problems in France.

      PubDate: 2016-09-26T20:14:29Z
      DOI: 10.1016/j.alcohol.2016.09.028
       
 
 
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