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Publisher: Elsevier   (Total: 3043 journals)

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Showing 1 - 200 of 3043 Journals sorted alphabetically
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 20, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 18, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 83, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 23, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 27, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 4)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 5, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 331, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 3)
Acta Biomaterialia     Hybrid Journal   (Followers: 25, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 1)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 211, SJR: 3.683, h-index: 202)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.615, h-index: 21)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 9, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription   (Followers: 1)
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 3, SJR: 0.311, h-index: 16)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 2)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 23, SJR: 1.365, h-index: 73)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 4)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 4, SJR: 0.383, h-index: 19)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 2)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 5, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 4, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 3)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 5)
Additive Manufacturing     Hybrid Journal   (Followers: 8, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 20)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 128, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 16, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 9, SJR: 0.299, h-index: 15)
Advances in Agronomy     Full-text available via subscription   (Followers: 15, SJR: 2.071, h-index: 82)
Advances in Anesthesia     Full-text available via subscription   (Followers: 25, SJR: 0.169, h-index: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 3)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 6, SJR: 1.054, h-index: 35)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 10, SJR: 0.801, h-index: 26)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 22, SJR: 1.286, h-index: 49)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
Advances in Botanical Research     Full-text available via subscription   (Followers: 3, SJR: 0.619, h-index: 48)
Advances in Cancer Research     Full-text available via subscription   (Followers: 25, SJR: 2.215, h-index: 78)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 0.9, h-index: 30)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 2.139, h-index: 42)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 24, SJR: 0.183, h-index: 23)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 10, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 16, SJR: 0.223, h-index: 22)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 11)
Advances in Digestive Medicine     Open Access   (Followers: 4)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Ecological Research     Full-text available via subscription   (Followers: 41, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 25, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 7)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 40, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 3)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 47, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 15)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 21, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.497, h-index: 31)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 25)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 35, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 3, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 5)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 4)
Advances in Life Course Research     Hybrid Journal   (Followers: 8, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 2)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Marine Biology     Full-text available via subscription   (Followers: 16, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 22)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 10)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 4)
Advances in Oncobiology     Full-text available via subscription   (Followers: 3)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 24, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 13)
Advances in Pharmacology     Full-text available via subscription   (Followers: 15, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 7, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 4)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 19, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 60)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 2, SJR: 0.1, h-index: 2)
Advances in Space Research     Full-text available via subscription   (Followers: 343, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 8)
Advances in Surgery     Full-text available via subscription   (Followers: 7, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 30, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 15)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 43, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 5, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 307, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 5, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 8, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 405, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 30, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 38, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access  
Agriculture and Natural Resources     Open Access   (Followers: 1)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 53, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 5, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 9, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 6)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access  
Algal Research     Partially Free   (Followers: 8, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 4, SJR: 0.776, h-index: 35)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 7, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 48, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 5)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 3)
American Heart J.     Hybrid Journal   (Followers: 48, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 45, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 38, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 6, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 16, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 31, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 24, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 33, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 46, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 191, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 54, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 3)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 23, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 26, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 21, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 34, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 5)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 55, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 10)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 2, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 38, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 162, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 8, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 11)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 1)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 22, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access  
Animal Behaviour     Hybrid Journal   (Followers: 157, SJR: 1.907, h-index: 126)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 5, SJR: 1.151, h-index: 83)
Animal Reproduction Science     Hybrid Journal   (Followers: 5, SJR: 0.711, h-index: 78)
Annales d'Endocrinologie     Full-text available via subscription   (Followers: 1, SJR: 0.394, h-index: 30)
Annales d'Urologie     Full-text available via subscription  
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (SJR: 0.177, h-index: 13)
Annales de Chirurgie de la Main et du Membre Supérieur     Full-text available via subscription  
Annales de Chirurgie Plastique Esthétique     Full-text available via subscription   (Followers: 2, SJR: 0.354, h-index: 22)
Annales de Chirurgie Vasculaire     Full-text available via subscription   (Followers: 1)

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Journal Cover Advances in Radiation Oncology
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  This is an Open Access Journal Open Access journal
   ISSN (Online) 2452-1094
   Published by Elsevier Homepage  [3043 journals]
  • Outcomes and toxicity of 313 prostate cancer patients receiving helical
           tomotherapy after radical prostatectomy

    • Authors: Lindsay Jensen; Bertram Yuh, Jeffrey Y.C. Wong, Timothy Schultheiss, Jonathan Cheng, Nora Ruel, Przemyslaw Twardowski, Sagus Sampath
      Abstract: There are limited long-term data on patients treated with image-guided intensity-modulated radiation therapy (IG-IMRT) for prostate cancer recurrence or high risk disease features following radical prostatectomy. We report single institution results for patients treated with IG-IMRT and identify variables associated with outcome.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-08-08
      DOI: 10.1016/j.adro.2017.08.004
       
  • Factors influencing the utilization of prophylactic cranial irradiation in
           patients with limited-stage small cell lung cancer

    • Authors: Benjamin H. Lok; Jennifer Ma, Amanda Foster, Carmen A. Perez, Weiji Shi, Zhigang Zhang, Bob T. Li, Charles M. Rudin, Andreas Rimner, Abraham J. Wu
      Abstract: Brain metastases are common in limited-stage small cell lung cancer (LS-SCLC) due to the inability of most chemotherapeutics to penetrate the blood-brain barrier. Prophylactic cranial irradiation (PCI) is therefore recommended for use in patients with a good response to concurrent chemoradiotherapy. However, PCI is not always delivered; therefore we investigate the reasons for PCI omission in patients who underwent therapy with curative intent.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-08-08
      DOI: 10.1016/j.adro.2017.08.001
       
  • SBRT to adrenal metastases provides high local control with minimal
           toxicity

    • Authors: Kristin Plichta; Nathan Camden, Muhammed Furqan, Taher Abu Hejleh, Gerald H. Clamon, Jun Zhang, Ryan T. Flynn, Sudershan K. Bhatia, Mark C. Smith, John M. Buatti, Bryan G. Allen
      Abstract: The adrenal glands are a common site of metastases because of their rich blood supply. Previously, adrenal metastases were treated with systemic chemotherapy or, more rarely, with surgical resection or palliative radiation therapy. Stereotactic body radiation therapy (SBRT) has recently emerged as an attractive non-invasive approach to definitively treat these lesions. We present our experience in treating adrenal metastases with SBRT and review the currentliterature.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-08-04
      DOI: 10.1016/j.adro.2017.07.011
       
  • Long-term analysis of two prospective studies that incorporate mitomycin C
           into an adjuvant chemoradiation regimen for pancreatic and periampullary
           cancers

    • Authors: Kathryn J. Schunke; Lauren M. Rosati, Marianna Zahurak, Joseph M. Herman, Amol K. Narang, Irina Usach, Alison P. Klein, Charles J. Yeo, Larry T. Korman, Ralph H. Hruban, John L. Cameron, Daniel A. Laheru, Ross A. Abrams
      Abstract: To report toxicity and long-term survival outcomes of two prospective trials evaluating mitomycin C (MMC) with 5-fluorouracil-based adjuvant chemoradiation in resected periampullary adenocarcinoma.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-08-03
      DOI: 10.1016/j.adro.2017.07.008
       
  • Serum testosterone changes in patients treated with radiotherapy alone for
           prostate cancer on nrg oncology rtog 9408

    • Authors: R. Charles Nichols; Chen Hu, Jean-Paul Bahary, Kenneth L. Zeitzer, Luis Souhami, Mark H. Leibenhaut, Marvin Rotman, Elizabeth M. Gore, Alexander G. Balogh, David McGowan, Jeff Michalski, Adam Raben, Shari Rudoler, Christopher U. Jones, Howard Sandler
      Abstract: We reviewed testosterone changes for patients treated with radiotherapy (RT) alone on XXXX.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-08-03
      DOI: 10.1016/j.adro.2017.07.004
       
  • The pervasive crisis of diminishing radiotherapy access for vulnerable
           populations in the united states – part 1: african-american patients

    • Authors: Shearwood McClelland; Brandi R Page, Jerry J Jaboin, Christina H Chapman, Curtiland Deville, Charles R Thomas
      Abstract: African-Americans suffer the highest burden of cancer incidence and mortality in the United States, and have been persistently less likely to receive interventional care, even when such care has been proven superior to conservative management by randomized controlled trials. The presence of disparities in access to radiotherapy (RT) for African-American cancer patients has rarely been examined in an expansive fashion.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-08-03
      DOI: 10.1016/j.adro.2017.07.002
       
  • The long-term economic value of hypofractionated prostate radiation:
           secondary analysis of a randomized trial

    • Authors: K. Ranh Voong; Lincy S. Lal, Deborah A. Kuban, Thomas J. Pugh, J. Michael Swint, Joy Godby, Seungtaek Choi, Andrew K. Lee, Pamela J. Schlembach, Steven J. Frank, Sean E. McGuire, Karen E. Hoffman
      Abstract: Moderately hypofractionated prostate radiation (HIMRT) shortens the treatment course while providing outcomes comparable to conventionally fractionated radiation (CIMRT). To determine the long-term economic value of HIMRT including the costs of managing long-term radiation toxicities, a cost minimization analysis compared CIMRT to dose-escalated HIMRT using patient-level data from a randomized trial.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-08-01
      DOI: 10.1016/j.adro.2017.07.010
       
  • Oncological outcomes from trimodality therapy receiving definitive doses
           of neoadjuvant chemoradiation (≥60 gy) and factors influencing
           consideration for surgery in stage III non-small cell lung cancer

    • Authors: Melissa A.L. Vyfhuis; Neha Bhooshan, Whitney M. Burrows, Michelle Turner, Mohan Suntharalingam, James Donahue, Elizabeth M. Nichols, Josephine Feliciano, Søren Bentzen, Shahed Badiyan, Shamus R. Carr, Joseph Friedberg, Charles B. Simone, Martin J. Edelman, Steven J. Feigenberg, Pranshu Mohindra
      Abstract: Guidelines for locally advanced non-small cell lung cancer (LA-NSCLC) recommend definitive chemoradiation for cN2-N3 disease, reserving surgery for patients with minimal nodal involvement at presentation. Current literature suggests that surgery after chemoradiation (CRT) for stage III NSCLC can improve freedom-from-recurrence (FFR), but has not consistently demonstrated an improvement in overall survival (OS), perhaps partly due to low (45-50.4Gy) preoperative doses delivered resulting in low rates of mediastinal nodal clearance (MNC).
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-07-31
      DOI: 10.1016/j.adro.2017.07.009
       
  • Outcomes and patterns of care in a nationwide cohort of pediatric
           medulloblastoma: factors affecting proton therapy utilization

    • Authors: Andrew S. Kopecky; Atif J Khan, Wilbur Pan, Richard Drachtman, Rahul R. Parikh
      Abstract: We examined national outcomes and patterns of care for pediatric patients with medulloblastoma (MB) in a large observational cohort.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-07-19
      DOI: 10.1016/j.adro.2017.07.007
       
  • Fractionated stereotactic radiation therapy for intact brain metastases

    • Authors: Samuel R. Marcrom; Andrew M. McDonald, Jonathan W. Thompson, Richard A. Popple, Kristen O. Riley, James M. Markert, Christopher D. Willey, Markus Bredel, John B. Fiveash
      Abstract: Limited data exists on fractionated stereotactic radiation therapy (FSRT) for brain metastases. We sought to evaluate the safety and efficacy of FSRT while further defining its role in brain metastasis management.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-07-19
      DOI: 10.1016/j.adro.2017.07.006
       
  • Axillary lymph node coverage with 3D tangential field irradiation and
           correlation with heart and lung dose

    • Authors: Geraldine Jacobson; Nicole Bunda-Randall, Sijin Wen, Matthew Miller
      Abstract: Purpose: The ACOSOG Z0011 trial indicated no benefit of axillary lymph node (LN) dissection following positive sentinel LN biopsy in patients receiving breast irradiation, suggesting that level I/II LNs were covered in tangential fieldsMethods and materials: We evaluated 50 CT-based tangential breast plans and contoured level I-III axillary LNs using RTOG guidelines. Volumes of level I-III LN regions covered by 90% and 95% of the prescription dose (PD) were calculated and correlated with the V20 ipsilateral lung and mean heart dose (MHD).
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-07-17
      DOI: 10.1016/j.adro.2017.07.005
       
  • Initiative to reduce bone scans for low-risk prostate cancer patients: a
           quasi-experimental before-and-after study in a veterans affairs hospital

    • Authors: Eric Ojerholm; Keith N. Van Arsdalen, Robert E. Roses, Patrick Tripp
      Abstract: Bone scans (BS) are a low-value test for asymptomatic men with low-risk prostate cancer. We performed a quality improvement intervention aimed at reducing BS for these patients.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-07-11
      DOI: 10.1016/j.adro.2017.07.001
       
  • Elective nodal dose of 60gy or 50gy in head and neck cancers: a matched
           pair analysis of outcomes and toxicity

    • Authors: Vedang Murthy; Lavanya Gurram, Sadhana Kannan, Minakshi Gandhi, Tejpal Gupta, Sarbani Ghosh Laskar, Ashwini Budrukkar, Jai Prakash Agarwal
      Abstract: The main objective of the present study was to evaluate appropriate doses for elective nodal irradiation (ENI) in head and neck squamous cell carcinoma (HNSCC) patients to optimize therapeutic ratio.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-06-21
      DOI: 10.1016/j.adro.2017.06.005
       
  • Effectiveness of low-dose radiation for primary cutaneous anaplastic large
           cell lymphoma

    • Authors: Grace L Smith; Madeleine Duvic, Zeinab Abou Yehia, Pamela Allen, Naveen Garg, Tina Suki, Sarah A Milgrom, Chelsea C Pinnix, Yasuhiro Oki, Joseph D. Khoury, Bouthaina S Dabaja
      Abstract: Primary cutaneous anaplastic large cell lymphoma (pcALCL) is conventionally treated with radiation (RT) doses ≥30 Gray (Gy), but effectiveness of lower doses is unclear. We compared responses after a range of RT doses for pcALCL.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-06-14
      DOI: 10.1016/j.adro.2017.06.004
       
  • Tweet for the cure: a Snapshot of Twitter Usage by Three U.S. Oncologic
           Professional Societies

    • Authors: Sachin R. Jhawar; Vinay Prabhu, Matthew S. Katz, Sabin B. Motwani
      Abstract: Medical societies are incorporating Twitter to communicate with their members and connect with their patients. This study compares the online presence of three major oncologic societies.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-06-13
      DOI: 10.1016/j.adro.2017.06.003
       
  • Clinical outcomes of intensity-modulated proton therapy and concurrent
           chemotherapy in esophageal carcinoma: a single institutional experience.

    • Authors: Anussara Prayongrat; Cai Xu, Heng Li, Steven H. Lin
      Abstract: Intensity-modulated proton therapy (IMPT) is an emerging advanced radiation technique. While dosimetric studies demonstrate the superiority of IMPT for improving target conformity and reducing unnecessary dose to critical normal tissues, clinical experience is currently limited. We aim to describe our preliminary experience implementing IMPT concurrently with chemotherapy in esophageal carcinoma (EC).
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-06-13
      DOI: 10.1016/j.adro.2017.06.002
       
  • Estimating prognosis at the time of repeat whole brain radiotherapy for
           multiple brain metastases: The ReRT score

    • Authors: Natalie Logie; Rachel Jimenez, Natalie Pulenzas, Kelly Linden, Denise Ciafone, Sunita Ghosh, Yuhui Xu, Shilo Lefresne, Erin Wong, Christina H. Son, Helen A. Shih, William Wong, Scott Tyldesley, Kristopher Dennis, Edward Chow, Alysa Fairchild
      Abstract: More than half of patients treated for multiple brain metastases with whole brain radiotherapy (WBRT) will develop intracranial progression. This multi-institutional pooled analysis included 205 patients from nine centres receiving two courses of WBRT, each for multiple metastases. In this cohort, application of the recursive partitioning analysis score was not predictive of median survival, leading to the construction of a new index, the ReRT score.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-06-13
      DOI: 10.1016/j.adro.2017.05.010
       
  • Abscopal effect in recurrent colorectal cancer treated with carbon-ion
           radiotherapy: two case reports

    • Authors: Daniel K. Ebner; Tadashi Kamada, Shigeru Yamada
      Abstract: The abscopal effect involves distant tumor regression following localized irradiation. It is rare and the mechanism of its behavior remains unclear. Two patients treated for recurrent colorectal cancer with carbon-ion radiotherapy demonstrated an apparent abscopal effect, with unirradiated, distant metastases shrinking or stable following treatment. Their cases are reported here.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-06-07
      DOI: 10.1016/j.adro.2017.06.001
       
  • A Method to Improve Dose Uniformity during Total Skin Electron Beam
           Therapy in Patients with Pendulous Breasts

    • Authors: Brian J. King; Christopher L. Deufel, Sarah E. Locher, Luke B. McLemore, Barbara S. Brekke-Hackman, James A. Martenson
      Abstract: Total skin electron beam therapy will not provide adequate radiation dose to the inframammary folds in patients with pendulous breasts. We utilized a nylon breast support sling during treatment. In vivo dosimetry revealed satisfactory radiation dose to the inframammary folds through the nylon support.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-06-06
      DOI: 10.1016/j.adro.2017.05.009
       
  • The Impact of Different Stereotactic Radiotherapy Regimens for Brain
           Metastases on Local Control and Toxicity

    • Authors: Rachel B. Jimenez; Brian M. Alexander, Anand Mahadevan, Andrzej Niemierko, Selvan Rajakesari, Nils D. Arvold, Scott R. Floyd, Kevin S. Oh, Jay S. Loeffler, Helen A. Shih
      Abstract: Stereotactic radiotherapy (hSRT) uses precisely focused radiation, often delivered in short courses, to brain metastases unsuited for single fraction treatment, but the optimal dose and fractionation schema remains unclear. We performed a multi-institutional retrospective review of patients treated with various SRT regimens. Total prescription dose was the only factor significantly associated with local control. Dose per fraction was not found to be associated with tumor control.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-06-06
      DOI: 10.1016/j.adro.2017.05.008
       
  • Carotid blowout after reirradiation with particle therapy

    • Authors: Jon Espen Dale; Silvia Molinelli, Elisa Ciurlia, Mario Ciocca, Maria Bonora, Viviana Vitolo, Alfredo Mirandola, Stefania Russo, Roberto Orecchia, Olav Dahl, Piero Fossati
      Abstract: We analyzed 96 patients reirradiated with particle therapy for recurrent cancer in the head and neck and skull base region, focusing on carotid blowout. Cumulative dose to the carotid was reconstructed. There were two cases of carotid blowout. Both events occurred in patients treated with protons, no event was observed with carbon ions. More data is needed to evaluate the impact of dosimetric variables and the potential role of selective carotid sparing.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-06-05
      DOI: 10.1016/j.adro.2017.05.007
       
  • Two-and-a-half year clinical experience with the world’s first magnetic
           resonance image-guided radiation therapy system

    • Authors: Benjamin Fischer-Valuck; Lauren Henke, Olga Green, Rojano Kashani, Sahaja Acharya, Jeffrey Bradley, Cliff Robinson, Maria Thomas, Imran Zoberi, Wade Thorstad, Hiram Gay, Jiayi Huang, Michael Roach, Vivian Rodriguez, Lakshmi Santanam, Harold Li, Hua Li, Jessika Contreras, Thomas Mazur, Dennis Hallahan, Jeff Olsen, Parag Parikh, Sasa Mutic, Jeff Michalski
      Abstract: MR-IGRT has been successfully implemented into a high-volume radiation clinic and provides unique advantages in the treatment of a variety of malignancies. We describe our initial clinical experience and integration of this new technology within a high-volume clinical practice, highlight the technical capabilities of the system, and describe the selection of patients who benefited most from MR-IGRT.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-06-01
      DOI: 10.1016/j.adro.2017.05.006
       
  • Detection of Regional Radiation-Induced Lung Injury using Hyperpolarized
           129Xe Chemical Shift Imaging in a Rat Model involving Partial Lung
           Irradiation: Proof-of-concept Demonstration

    • Authors: Brandon Zanette; Elaine Stirrat, Salomeh Jelveh, Andrew Hope, Giles E. Santyr
      Abstract: Dissolved 129Xe MRI signal intensity and heterogeneity were observed to change asymmetrically between the right and left lungs after partial right lung irradiation in a rat model of RILI four weeks post irradiation. These results correlated with quantitative histology of pulmonary tissue and red blood cells.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-05-26
      DOI: 10.1016/j.adro.2017.05.005
       
  • ASTRO’s Advances in Radiation Oncology – Success to date and
           future plans

    • Authors: Robert C. Miller; Sharad Goyal, Shearwood McClelland, Sabin Motwani, Charles Mayo, Tasneem Kaleem, Gregory Videtic, Kathleen Hintenlang
      Abstract: ASTRO’s Advances in Radiation Oncology was launched as a new, peer reviewed scientific journal in December of 2015. Over 200 manuscripts have been submitted and 97 accepted for publication as of May 2017. As Advances enters its second year of publication, we have chosen to highlight subjects that will transform the way we practice radiation oncology in special issues or ongoing series: Immunotherapy, biomedical analytics, and social media. A teaching case report contest for North American radiation oncology residents will be launched at ASTRO 2017 to encourage participation by trainees in the scientific publication early in their careers.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-05-26
      DOI: 10.1016/j.adro.2017.05.004
       
  • Neoadjuvant twice daily chemoradiotherapy for esophageal cancer: treatment
           related mortality and long-term outcomes

    • Authors: Stuart E. Samuels; Matthew H. Stenmark, Jae Y. Lee, Jonathan B. McHugh, James A. Hayman, Mark B. Orringer, Susan G. Urba, Libin Sun, Congying Xie, Feng-Ming Kong, Kyle C. Cuneo
      Abstract: In this report we investigate the treatment related mortality risk and survival outcomes of 250 patients treated with twice daily neoadjuvant chemoradiation followed by transhiatal esophagectomy. This treatment regimen is an effective therapy with outcomes equivalent or better to those reported in other studies and is associated with minimal treatment related mortality. Additionally, pathological response to hyperfractioned accelerated chemoradiation therapy is associated with improved overall survival and local control.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-05-24
      DOI: 10.1016/j.adro.2017.05.003
       
  • Impact on quality of life of IMRT versus 3-D conformal radiotherapy in
           head and neck cancer patients: A case-control study

    • Authors: Edvard Abel; Ewa Silander, Jan Nyman, Mogens Bove, Leif Johansson, Thomas Björk-Eriksson, Eva Hammerlid
      Abstract: Intensity-modulated radiotherapy (IMRT) is believed to be advantageous compared to conventional dose-planning in terms of decreasing radiation burden to organs at risk. In this case-control study we aimed at collecting health-realted quality of life(HRQOL) data in patients with head and neck cancer treated with either IMRT or three-dimensional conventional radiotherapy(3D-CRT). The results of the study further adds to the knowledgebase of the actual clinical benefits of adopting new radiotherapy techniques.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-05-12
      DOI: 10.1016/j.adro.2017.05.002
       
  • Social Media for Radiation oncologists: A Practical Primer

    • Authors: Jean-Emmanuel Bibault; Matthew S. Katz, Sabin Motwani
      Abstract: Social media is a powerful tool to exchange and disseminate knowledge. It can be used to enhance and share the value of our profession to a wider audience by creating an online presence, connecting to other healthcare professionals, sharing information with patients, keeping up to date on specific subjects, and facilitating virtual attendance at medical conferences. However, using these new tools can be difficult and a set of best practices is now available to physicians who wish to engage with patients or colleagues through social media.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-05-09
      DOI: 10.1016/j.adro.2017.04.009
       
  • 2D kV Orthogonal Imaging with Fiducial Markers is More Precise for Daily
           Image-Guided Alignments than Soft-tissue Cone Beam Computed Tomography for
           Prostate Radiotherapy

    • Authors: Peter H. Goff; Louis B. Harrison, Eli Furhang, Evan Ng, Stephen Bhatia, Frieda Trichter, Ronald D. Ennis
      Abstract: Summary
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-05-04
      DOI: 10.1016/j.adro.2017.05.001
       
  • Use of Regional Nodal Irradiation and its Association with Survival for
           Women with High-Risk, Early-Stage Breast Cancer: A National Cancer Data
           Base Analysis

    • Authors: Amy C. Moreno; Yan Heather Lin, Isabelle Bedrosian, Yu Shen, Michael C. Stauder, Benjamin D. Smith, Thomas A. Buchholz, Gildy V. Babiera, Wendy A. Woodward, Simona F. Shaitelman
      Abstract: The role of regional nodal irradiation (RNI) in the management of subgroups of patients with early stage breast cancer remains controversial. Using the National Cancer Data Base, we demonstrate that nearly one-third of women who met the selection criteria for the large National Cancer Institute of Canada MA.20 trial received RNI between 2004-2012. No significant improvement in 5-year overall survival was identified, regardless of pathological nodal involvement, in accordance with the MA.20 trial findings.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-05-03
      DOI: 10.1016/j.adro.2017.04.008
       
  • Quantitative FDG - PET/CT Predicts Local Recurrence and Survival for
           Squamous Cell Carcinoma of the Anus

    • Authors: Michael L. Cardenas; Christopher R. Spencer, Stephanie Markovina, Todd A. DeWees, Thomas R. Mazur, Ashley A. Weiner, Parag J. Parikh, Jeffrey R. Olsen
      Abstract: We sought to investigate the relationship of FDG avidity on PET/CT scan with clinical outcomes for patients treated definitively with radiotherapy for squamous cell carcinoma of the anus.This was a retrospective study assessing pre-treatment and post-treatment PET/CT. FDG avidity is quantified by the maximum standardized uptake value as computed on medical imaging analysis software.Our data show this quantitative metric of avidity to be predictive of clinical outcomes.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-04-28
      DOI: 10.1016/j.adro.2017.04.007
       
  • Orthogonal Image Pairs Coupled with OSMS for Non-Coplanar Beam Angle
           Intracranial Single-Isocenter SRS Treatments with Multiple Targets on the
           Varian Edge™ Radiosurgery System

    • Authors: Jasmine A. Oliver; Patrick Kelly, Sanford L. Meeks, Twyla R. Willoughby, Amish P. Shah
      Abstract: To reduce the number of CBCTs during SRS treatments, we characterized the accuracy of non-coplanar IGRT on the Varian EDGE™ Radiosurgery System for intracranial SRS treatments using a CIRS head phantom and Encompass SRS Immobilization System by determining collision-free space that orthogonal pairs can be obtained and assessing accuracy of kV-kV orthogonal pair registration with OSMS monitoring relative to CBCT as the gold standard. This technique provides accurate and safe treatments with negligible dosimetric effects.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-04-26
      DOI: 10.1016/j.adro.2017.04.006
       
  • Incorporating Big Data into Treatment Plan Evaluation – Development of
           Statistical DVH Metrics and Visualization Dashboards

    • Authors: Charles Mayo; John Yao, Avraham Eisbruch, James Balter, Dale Litzenberg, Martha Matuszak, Marc Kessler, Grant Weyburn, Carlos Anderson, Dawn Owen, William Jackson, Randall Ten Haken
      Abstract: We demonstrate the utility of an in house developed DVH-based metrics and visualization method. Use of the metrics to summarize historical experience for two patient groups: 1) head and neck and 2) prostate patients was demonstrated. This tool allows for simple and intuitive quantification of the comparison of individual treatment plans against historical experiences. As such, this may allow for superior treatment planning which has the potential to result in improved patient care.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-04-26
      DOI: 10.1016/j.adro.2017.04.005
       
  • Diffuse large B- cell lymphoma in very elderly patients over 80 years old:
           incorporating consolidative radiation therapy into management decisions

    • Authors: Chelsea C. Pinnix; Therese Y. Andraos, Bouthaina Dabaja, Sarah Milgrom, Grace Smith, Dai Chihara, Andrea Ng, Luis E. Fayad, Yasuhiro Oki, Sattva Neelapu, Jason Westin, M. Alma Rodriguez, Loretta J. Nastoupil
      Abstract: In a cohort of 131 patients with DLBCL age 80 and older with chemo-sensitive disease, outcomes rivaled those of younger patients. For limited stage disease, abbreviated chemotherapy followed by consolidative radiation therapy was equivalent in efficacy to chemotherapy alone (6-8 cycles), but was associated with lower rates of myelosuppression, neuropathy and congestive heart failure. In advanced stage patients, radiation therapy appeared to improve local control. Older patients should be considered for consolidative RT after immunochemotherapy.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-04-21
      DOI: 10.1016/j.adro.2017.04.004
       
  • Reducing Radiation Dose and Enhancing Imaging Quality of 4DCT for
           Radiation Therapy Using Iterative Reconstruction Algorithms

    • Authors: George Noid; An Tai, Guang-Pei Chen, Jared Robbins, X. Allen Li
      Abstract: Time sorted 4DCT scans are used in radiation therapy (RT) for motion management; however these scans are associated with elevated dose to the patient. Iterative image reconstruction algorithms are known to reduce the imaging dose by 30-50% while maintaining the signal to noise ratio. The study aims to evaluate whether one such iterative reconstruction algorithm, SAFIRE, can reduce imaging dose while maintaining the necessary contrast-to-noise to generate clinically valid 4DCT datasets.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-04-21
      DOI: 10.1016/j.adro.2017.04.003
       
  • Long Term Survival and Toxicity Outcomes of Intensity-Modulated Radiation
           Therapy for the Treatment of Esophageal Cancer: A Large
           Single-Institutional Cohort Study

    • Authors: Anhui Shi; Zhongxing Liao, Pamela K. Allen, Linus Ho, Mariela Blum Murphy, Dipen M. Maru, Stephen G. Swisher, Wayne L. Hofstetter, Reza J. Mehran, James D. Cox, Ritsuko Komaki, Steven H. Lin
      Abstract: Radiotherapy is an integral part in the management of esophageal cancer. While the current standard is 3D conformal radiotherapy, Intensity Modulated Radiation Therapy (IMRT) affords improved organ sparing effects over the 3D technique. However, reported clinical experience using IMRT has been sparse. Herein we report the largest single institutional experience using IMRT, demonstrating excellent toxicity and survival outcomes relative to historical controls for patients treated with neoadjuvant or definitive chemoradiotherapy.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-04-18
      DOI: 10.1016/j.adro.2017.04.002
       
  • Preoperative radiation dose escalation for rectal cancer using a
           concomitant boost strategy improves tumor downstaging without increasing
           toxicity: A matched-pair analysis

    • Authors: Jillian R. Gunther; Awalpreet S. Chadha, Ui Sup Shin, In Ja Park, Kiran V. Kattepogu, Jonathan D. Grant, David C. Weksberg, Cathy Eng, Scott E. Kopetz, Prajnan Das, Marc E. Delclos, Harmeet Kaur, Dipen M. Maru, John M. Skibber, Miguel A. Rodriguez-Bigas, Y Nancy You, Sunil Krishnan, George J. Chang.
      Abstract: Locally advanced rectal cancer (LARC) patients who achieve complete pathologic response after neoadjuvant chemoradiation experience improved outcomes. Radiation dose escalation has been shown to improve rates of tumor response. We conducted a case-control study of LARC patients who received standard dose or concomitant boost chemoradiation prior to surgical resection. Boost patients had improved tumor downstaging and local control without increases in early or late toxicity including surgical complications.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-04-11
      DOI: 10.1016/j.adro.2017.04.001
       
  • 4-1BB (CD137) and radiotherapy: A Case report and Literature Review

    • Authors: Jay Shiao; Nathan Bowers, Tahseen H. Nasti, Faisal Khosa, Mohammad K. Khan
      Abstract: Emerging immuno-oncology combination strategies include utilizing radiotherapy (RT) with immunotherapeutic checkpoint blockade monoclonal antibodies (mAbs) such as CTLA-4 and PD-1, represent a new and exciting strategy to improve outcomes in solid tumor malignancies [1, 2]. RT has the potential to augment immune responses [3, 4], and cancer cells destroyed by RT are considered to be a source of tumor associated antigens that can be processed by professional antigen presenting cells (APCs) [5].
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-04-03
      DOI: 10.1016/j.adro.2017.03.007
       
  • Dosimetric and Clinical Outcomes After Volumetric Modulated arc Therapy
           for Carcinoma of the Thoracic Esophagus

    • Authors: Cai Xu; Mian Xi, Ritsuko Komaki, Peter A. Balter, Meilin Huang, Brian P. Hobbs, Luhua Wang, Steven H. Lin
      Abstract: Outcomes after Volumetric Modulated Arc Therapy (VMAT) for thoracic esophageal carcinoma are largely unknown. We conducted a propensity matched analysis of 65 patients treated with VMAT and concurrent chemotherapy with 130 patients treated with step-and-shoot (ss)IMRT and concurrent chemotherapy and found VMAT had better target conformity with comparable toxicity, response, recurrence and survival outcomes. VMAT is an efficient, safe and effective radiation delivery method for the treatment of esophageal cancer.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-03-27
      DOI: 10.1016/j.adro.2017.03.006
       
  • Simulating Intrafraction Prostate Motion with a Random Walk Model

    • Authors: Tobias Pommer; Jung Hun Oh, Per Munck af Rosenschöld, Joseph O. Deasy
      Abstract: Prostate motion during radiotherapy is one of the factors limiting its accuracy. In this study, we modeled prostate motion as a random walk. With access to time-resolved prostate motion during radiotherapy from 17 patients we performed a detailed analysis and time-resolved simulations. We found that random walk is a viable option for prostate motion modeling and can potentially be used to simulate radiotherapy delivery and analyze treatment margins.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-03-27
      DOI: 10.1016/j.adro.2017.03.005
       
  • ACR Appropriateness Criteria® External Beam Radiation Therapy Treatment
           Planning for Clinically Localized Prostate Cancer, Part II of II

    • Authors: Expert Panel on Radiation Oncology–Prostate; Nicholas G. Zaorsky, Timothy N. Showalter, Gary A. Ezzell, Paul L. Nguyen, Dean G. Assimos, Anthony V. D'Amico, Alexander R. Gottschalk, Gary S. Gustafson, Sameer R. Keole, Stanley L. Liauw, Shane Lloyd, Patrick W. McLaughlin, Benjamin Movsas, Bradley R. Prestidge, Al V. Taira, Neha Vapiwala, Brian J. Davis
      Abstract: To (1) present the most updated American College of Radiology Appropriateness Criteria formed from an expert panel on the appropriate delivery of external beam radiation to manage stage T1 and T2 prostate cancer (in the definitive setting and post-prostatectomy); and (2) provide clinical variants with expert recommendations, based on an accompanying Appropriateness Criteria for target volumes and treatment planning.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-03-21
      DOI: 10.1016/j.adro.2017.03.003
       
  • Dose escalation with an IMRT technique in 15 to 28 fractions is better
           tolerated than standard doses of 3DCRT for LAPC

    • Authors: Lauren E. Colbert; Shalini Moningi, Awalpreet Chadha, Ahmed Amer, Yeonju Lee, Robert A. Wolff, Gauri Varadhachary, Jason Fleming, Matthew Katz, Prajnan Das, Sunil Krishnan, Eugene J. Koay, Peter Park, Christopher H. Crane, Cullen M. Taniguchi
      Abstract: Patients with LAPC who received induction chemotherapy followed by chemoradiation with definitive intent between 2005 and 2016 were reviewed. Toxicities for patients treated with escalated dose radiation therapy (EDR) utilizing an intensity modulated radiation therapy technique were recorded. Overall acute and late toxicity rates with EDR were low. Patients experienced lower gastrointestinal and overall toxicity as compared to patients treated with conventional doses and 3D conformal techniques.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-03-18
      DOI: 10.1016/j.adro.2017.02.004
       
  • Audiovisual biofeedback guided breath-hold improves lung tumor position
           reproducibility and volume consistency

    • Authors: Danny Lee; Peter B. Greer, Carminia Lapuz, Joanna Ludbrook, Perry Hunter, Jameen Arm, Sean Pollock, Kuldeep Makhija, Ricky T. O'Brien, Taeho Kim, Paul Keall
      Abstract: We investigated the impact of audiovisual biofeedback breath-hold guidance on MRI measured lung tumor position reproducibility and volume consistency. Inhalation and exhalation breath-hold positions determined in a breath-hold training session were utilized across two MRI sessions (pre- and mid-treatment). Inter-fraction lung tumor position and volume were significantly more reproducible and consistent respectively when utilizing audiovisual biofeedback breath-hold compared to conventional breath-hold with audio-instructions alone.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-03-09
      DOI: 10.1016/j.adro.2017.03.002
       
  • A rare case of appendicular skeleton localization in a patient with
           Chronic Lymphocytic Leukemia (CLL) successfully treated with salvage
           radiotherapy

    • Authors: Carmelo Tuscano; Iolanda Donatella Vincelli, Demetrio Arico’, Anna Maria Marchione, Paolo Versace, Caterina Stelitano, Giuseppe Sceni, Francesca Ronco, Elvio Grazioso Russi, Said Al Sayyad
      Abstract: Bone involvments by Chronic Lymphocytic Leukemia (CLL) are considered rare events and English Medical Literature describes them only in sporadic case reports. Consequently robust indications for a rational clinical management are lacking. We report the case of a middle age man in clinical follow-up for a CLL who complained about a Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) refractory pain at right tibial level and an acute episode of anemia. Instrumental exams and a bioptic sample surprisingly demonstrated a bone tibial localization by CLL.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-01-24
      DOI: 10.1016/j.adro.2017.01.007
       
  • Pathologic Response after Neoadjuvant Chemotherapy Predicts Locoregional
           Control in Patients with Triple Negative Breast Cancer

    • Authors: Victor E. Chen; Erin F. Gillespie, Kaveh Zakeri, James D. Murphy, Catheryn M. Yashar, Sharon Lu, John P. Einck
      First page: 105
      Abstract: The purpose of this manuscript is to describe how pathologic response after neoadjuvant chemotherapy for triple negative breast cancer impacts locoregional recurrence risk and disease-free survival in the setting of adjuvant radiation. This is a single-institution, retrospective study. We conclude that presence of residual disease in either breast or nodes is associated with significantly higher rates of locoregional failure as well as lower disease-free survival despite adjuvant radiation.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-02-07
      DOI: 10.1016/j.adro.2017.01.012
       
  • Long Term Outcomes and Toxicities of a Large Cohort of Anal Cancer
           Patients Treated with Dose Painted IMRT Per RTOG 0529

    • Authors: Devarati Mitra; Theodore S. Hong, Nora Horick, Brent Rose, Lorraine N. Drapek, Lawrence S. Blaszkowsky, Jill N. Allen, Eunice L. Kwak, Janet E. Murphy, Jeffrey W. Clark, David P. Ryan, James C. Cusack, Liliana G. Bordeianou, David L. Berger, Jennifer Y. Wo
      First page: 110
      Abstract: RTOG 0529 was a phase 2 study of 52 anal cancer patients prospectively treated with dose-painted intensity modulated radiation therapy. The current study of 99 patients at a single institution with a median 49 month follow-up is the largest-to-date analysis of survival, recurrence, colostomy rates and acute as well as late toxicity treated using this standardized approach. Overall this study shows long term outcomes and tolerability are excellent.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-02-06
      DOI: 10.1016/j.adro.2017.01.009
       
  • Serum Lipidomic study reveals potential early biomarkers for predicting
           response to chemoradiotherapy in advanced rectal cancer: a pilot study

    • Authors: Piero Del Boccio; Francesca Perrotti, Claudia Rossi, Ilaria Cicalini, Sara Di Santo, Mirco Zucchelli, Paolo Sacchetta, Domenico Genovesi, Damiana Pieragostino
      First page: 118
      Abstract: This study aims to highlight a typical lipid signature able to predict the tumor response to preoperative chemoradiotherapy in advanced rectal cancer, by using a Lipidomics approach. Five lipids were validated as biomarkers able to predict response before treatment, resulting in a ROC curve characterized by an (area under the curve) AUC of 0.95. Results suggest as serum lipids could represent an useful tool in prediction of CRT response, towards a personalized treatment.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-01-05
      DOI: 10.1016/j.adro.2016.12.005
       
  • A comparison of inter-fraction setup error, patient comfort and therapist
           

    • Authors: Eric Pei Ping Pang; Kellie Knight, Marilyn Baird, Joshua Ming Quan Loh, Adelene Hwee San Boo, Jeffrey Kit Loong Tuan
      First page: 125
      Abstract: This study investigates the magnitude of inter-fraction setup error, level of patient comfort and radiation therapist (RT) acceptance of the immobilisation device required to implement transperineal ultrasound (TPUS) compared to the current standard immobilisation device. Inter-fraction setup shifts were compared and questionnaires were used to illicit patient and RT perceptions. The Clarity immobilisation system (CIS) was stable, reproducible and well tolerated by patients. RTs preferred the leg immobiliser (LI) over the CIS.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-02-15
      DOI: 10.1016/j.adro.2017.02.001
       
  • Sociodemographic Disparities in the Utilization of Proton Therapy for
           Prostate Cancer at an Urban, Academic Center

    • Authors: Kristina D. Woodhouse; Wei-Ting Hwang, Neha Vapiwala, Akansha Jain, Xingmei Wang, Stefan Both, Meera Shah, Marquise Frazier, Peter Gabriel, John P. Christodouleas, Zelig Tochner, Curtiland Deville
      First page: 132
      Abstract: In this study, we examined whether disparities exist in proton therapy utilization in low and intermediate risk prostate cancer patients at a single academic, urban institution and found on multivariable analysis that only demographic characteristics, such as race and distance residing from the facility, as well as treatment physician and year, remained associated with proton therapy utilization, while clinical characteristics did not.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-01-17
      DOI: 10.1016/j.adro.2017.01.004
       
  • Characterization of Efficacy and Toxicity Following High-Dose Pelvic
           Re-Irradiation with Palliative Intent for Genitourinary Second Malignant
           Neoplasms or Local Recurrences after Full-Dose Radiotherapy in the Pelvis:
           A High-Volume Cancer Center Experience

    • Authors: Sophia C. Kamran; Lauren C. Harshman, Mandar S. Bhagwat, Vinayak Muralidhar, Paul L. Nguyen, Neil E. Martin, Stephanie La Follette, Sarah Faso, Akila N. Viswanathan, Jason A. Efstathiou, Clair J. Beard
      First page: 140
      Abstract: This study assesses outcomes of 28 patients who presented with either a second malignant genitourinary malignancy or a local recurrence after radical pelvic radiotherapy for a primary malignancy. All had advanced, symptomatic, inoperable bulky disease refractory to systemic therapy and/or narcotics and thus received high dose re-irradiation (re-RT) for palliation of either pain or bleeding. Re-RT was well tolerated with minor short-term toxicity and 92% control of symptoms, which was durable in 67% of patients.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-01-16
      DOI: 10.1016/j.adro.2017.01.001
       
  • Intensity Modulated Radiation Therapy for Squamous Cell Carcinoma of the
           Vulva: Treatment Technique and Outcomes

    • Authors: Yuan James Rao; Anupama Chundury, Julie K. Schwarz, Comron Hassanzadeh, Todd DeWees, Daniel Mullen, Matthew A. Powell, David G. Mutch, Perry W. Grigsby
      First page: 148
      Abstract: We present the treatment technique and outcomes from a retrospective review of 39 patients with squamous cell carcinoma of the vulva treated with IMRT. The 3-year locoregional control was 89% in patients treated post-operatively, and 42% in patients treated definitively. Complete pathological response was observed in 44% of patients treated with definitive or neoadjuvant IMRT. There was limited acute and late toxicity.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-02-28
      DOI: 10.1016/j.adro.2017.02.006
       
  • Adjuvant radiation for salivary gland malignancies is associated with
           improved survival: A national cancer database analysis

    • Authors: Richard L. Bakst; William Su, Umut Ozbek, Miriam A. Knoll, Brett A. Miles, Vishal Gupta, Ryan Rhome
      First page: 159
      Abstract: We aimed to investigate whether adjuvant radiation improves overall survival in major salivary gland cancers. Furthermore, we wanted to identify which subset of patients benefits the most from receiving radiation. 8243 patients with salivary gland cancer were identified from the NCDB. Patients in the high-risk group had greater survival (HR = 0.76; p=.002) if they received adjuvant radiation therapy.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-04-05
      DOI: 10.1016/j.adro.2017.03.008
       
  • Magnetic Resonance Imaging-Guided Re-irradiation of Recurrent and Second
           Primary Head and Neck Cancer

    • Authors: Allen M. Chen; Minsong Cao, Sophia Hsu, James Lamb, Argin Mikaeilian, Yingli Yang, Nzhde Agazaryan, Daniel A. Low, Michael L. Steinberg
      First page: 167
      Abstract: Magnetic resonance imaging (MRI)-guided intensity-modulated radiotherapy (IMRT) is a relatively novel technique that has the potential to improve the therapeutic ratio for tumors of the head and neck due to its superior ability to visualize soft tissue compared to the computed tomography (CT)-based image-guided platforms, which have historically been used. This study reports our preliminary experience with the use of MRI-guided re-irradiation for recurrent head neck tumors.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-02-20
      DOI: 10.1016/j.adro.2017.02.002
       
  • Preserving the legacy of re-irradiation: a narrative review of historical
           publications

    • Authors: Carsten Nieder; Johannes A. Langendijk, Matthias Guckenberger, Anca L. Grosu
      First page: 176
      Abstract: Both hematological malignancies and solid tumors were treated with a second course of radiotherapy already in the first half of the 20th century and indications included local relapse, regional nodal recurrence and second primary tumors developing in a previously treated region. Treatment approaches included external beam radiotherapy, brachytherapy or combinations thereof. Breast cancer, gynecological tumors, head and neck, brain and skin tumors are among the entities included in this review.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-02-28
      DOI: 10.1016/j.adro.2017.02.005
       
  • Functional Image-Guided Radiotherapy Planning in Volumetric Modulated Arc
           Therapy for Patients with Malignant Pleural Mesothelioma

    • Authors: Yoshiko Doi; Tomoki Kimura, Takeo Nakashima, Yuki Takeuchi, Ippei Takahashi, Ikuno Nishibuchi, Yuji Murakami, Yasushi Nagata
      First page: 183
      Abstract: We evaluated the possibility of incorporating functional lung image-derived low-attenuation area based on four-dimensional computed tomography into volumetric modulated arc therapy following extrapleural pneumonectomy in patients with malignant pleural mesothelioma. V5, V10, and the mean lung irradiation dose of the functional and contralateral lung were significantly reduced with the functional image-guided plan, and there were no major changes in PTV coverage or increases in organ-at-risk doses.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-02-01
      DOI: 10.1016/j.adro.2017.01.011
       
  • The Relationship Between Cardiac Radiation Dose and Mediastinal Lymph Node
           Involvement in Stage III Non-Small Cell Lung Cancer Patients

    • Authors: Laura K. McNew; Stephen R. Bowen, Olga Gopan, Matthew J. Nyflot, Shilpen A. Patel, Jing Zeng, Ramesh Rengan
      First page: 192
      Abstract: The intention of this study was to establish a relationship between mediastinal lymph node involvement and heart dose in patients treated with definitive radiotherapy for stage III non-small cell lung cancer. In our cohort of patients, were able to show that heart dose was correlated with both multi-station nodal involvement and subcarinal nodal involvement, and therefore may be a surrogate for extent of nodal involvement rather than an independent predictor of survival.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-01-31
      DOI: 10.1016/j.adro.2017.01.008
       
  • Importance of baseline PET/CT imaging on radiation field design and
           relapse rates in patients with Hodgkin Lymphoma

    • Authors: Nick Figura; Stella Flampouri, Nancy P. Mendenhall, Christopher G. Morris, Barry McCook, Savas Ozdemir, William Slayton, Eric Sandler, Bradford S. Hoppe
      First page: 197
      Abstract: The present study evaluated 37 patients with stage I or II Hodgkin lymphoma (HL) in order to understand the impact positron emission tomography–computed tomography (PET/CT) scans had on involved site radiotherapy (ISRT) field design and pattern of relapse among HL patients. These patients received first-line chemotherapy followed by consolidative involved site radiotherapy (ISRT) to all initial sites of disease. The study found that patients with stage I/II HL receiving ISRT without pretreatment PET-CT scans appear to have an increased risk for relapse in adjacent nodal stations just outside the radiation field.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-01-17
      DOI: 10.1016/j.adro.2017.01.006
       
  • 18F-FDG PET response and clinical outcomes after stereotactic body
           radiotherapy for metastatic melanoma

    • Authors: Ryan S. Youland; Ann T. Packard, Miran J. Blanchard, Andrea L. Arnett, Gregory A. Wiseman, Lisa A. Kottschade, Roxana S. Dronca, Svetomir N. Markovic, Kenneth R. Olivier, Sean S. Park
      First page: 204
      Abstract: This study assessed outcomes for oligometastatic malignant melanoma treated with stereotactic body radiotherapy (SBRT). Patients with pre- and post-treatment 18F-FDG-PET/CT scans were included. Metastasis control was excellent after SBRT and majority of patients achieved a complete metabolic response. Single-fraction equivalent dose > 24 Gy resulted in the optimal metastasis control. Prospectively captured acute and late toxicity were minimal. SBRT should be discussed with oligometastatic MM patients in addition to surgery and ablation options.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-02-23
      DOI: 10.1016/j.adro.2017.02.003
       
  • Patient-Reported Distress and Survival Among Patients Receiving Definitive
           Radiotherapy

    • Authors: Yacob Habboush; Robert P. Shannon, Shehzad K. Niazi, Laeticia Hollant, Megan Single, Kate Gaines, Bridget Smart, Nicolette T. Chimato, Michael G. Heckman, Steven J. Buskirk, Laura A. Vallow, Katherine S. Tzou, Stephen J. Ko, Jennifer L. Peterson, Heather A. Biers, Atiya B. Day, Kimberly A. Nelson, Jeff A. Sloan, Michele Y. Halyard, Robert C. Miller
      First page: 211
      Abstract: Patient-reported distress (PRD) has not been assessed in association with survival after radiotherapy (RT). This study aimed to evaluate the association between PRD level and survival after definitive RT by retrospectively reviewing a PRD questionnaire completed by patients undergoing definitive RT. The study showed that higher distress is associated with decreased survival.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-03-21
      DOI: 10.1016/j.adro.2017.03.004
       
  • Effects of Vertebral Body Sparing Proton Craniospinal Irradiation on the
           Spine of Young Pediatric Patients with Medulloblastoma

    • Authors: Iain MacEwan; Brian Chou, Jeremy Moretz, Lilia Loredo, David Bush, Jerry D. Slater
      First page: 220
      Abstract: This retrospective review evaluated the long-term consequences of vertebral body sparing proton CSI on young children with medulloblastoma. Clinical endpoints were measured including chronic back pain, diagnosis of scoliosis, and need for spine surgery. Radiographic endpoints were measured including scoliosis and changes in vertebral body height, as well as bone marrow changes in the vertebral body. With this limited cohort we found no severe spinal toxicities from this treatment technique and excellent disease control.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-03-09
      DOI: 10.1016/j.adro.2017.03.001
       
  • Comparison of Height and Weight After 12 vs. 18 Gy Cranial Radiotherapy in
           Pediatric Acute Lymphoblastic Leukemia (ALL) Patients

    • Authors: Albert C. Chen; M. Fatih Okcu, ZoAnn E. Dreyer, Kala Y. Kamdar, Rona Y. Sonabend, Hilary S. Suzawa, Eunji Jo, Arnold C. Paulino
      First page: 228
      Abstract: Cranial radiotherapy (RT) prevents and controls disease in the central nervous system of acute lymphoblastic leukemia (ALL) patients but causes long term side effects, especially growth abnormalities. Prior studies of children receiving 18 Gy have shown significant height impairment, but the effect of 12 Gy on height and weight indices is unknown. This study focuses on ALL patients treated with either 12 or 18 Gy cranial RT and followed in the long term survivors’ clinic.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-01-31
      DOI: 10.1016/j.adro.2017.01.010
       
  • Impact of prone versus supine positioning on small bowel dose with pelvic
           IMRT

    • Authors: Victor J. Gonzalez; Craig R. Hullett, Lindsay Burt, Prema Rassiah-Szegedi, Vikren Sarkar, Jonathan D. Tward, Lisa J. Hazard, Y. Jessica Huang, Bill J. Salter, David K. Gaffney
      First page: 235
      Abstract: To evaluate whether the dosimetric advantage of prone positioning with IMRT is maintained throughout the entire treatment course, we conducted a prospective study in which 10 patients had prone and supine plans generated. Patients were re-scanned weekly in both positions and “delivered” doses were re-calculated for each fraction. We conclude that prone positioning with a belly-board may provide superior small bowel sparing to supine IMRT with similar interfraction dose variation to supine treatment.
      Citation: Advances in Radiation Oncology (2017)
      PubDate: 2017-01-23
      DOI: 10.1016/j.adro.2017.01.005
       
 
 
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