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Publisher: Elsevier   (Total: 3163 journals)

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Showing 1 - 200 of 3163 Journals sorted alphabetically
A Practical Logic of Cognitive Systems     Full-text available via subscription   (Followers: 9)
AASRI Procedia     Open Access   (Followers: 14)
Academic Pediatrics     Hybrid Journal   (Followers: 30, SJR: 1.655, CiteScore: 2)
Academic Radiology     Hybrid Journal   (Followers: 22, SJR: 1.015, CiteScore: 2)
Accident Analysis & Prevention     Partially Free   (Followers: 88, SJR: 1.462, CiteScore: 3)
Accounting Forum     Hybrid Journal   (Followers: 25, SJR: 0.932, CiteScore: 2)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 35, SJR: 1.771, CiteScore: 3)
Achievements in the Life Sciences     Open Access   (Followers: 5)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 7)
Acta Astronautica     Hybrid Journal   (Followers: 394, SJR: 0.758, CiteScore: 2)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 2)
Acta Biomaterialia     Hybrid Journal   (Followers: 27, SJR: 1.967, CiteScore: 7)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 2)
Acta de Investigación Psicológica     Open Access   (Followers: 3)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.18, CiteScore: 1)
Acta Haematologica Polonica     Free   (Followers: 1, SJR: 0.128, CiteScore: 0)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.661, CiteScore: 2)
Acta Materialia     Hybrid Journal   (Followers: 244, SJR: 3.263, CiteScore: 6)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.504, CiteScore: 1)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.542, CiteScore: 1)
Acta Oecologica     Hybrid Journal   (Followers: 10, SJR: 0.834, CiteScore: 2)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription  
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 2, SJR: 0.307, CiteScore: 0)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1, SJR: 1.793, CiteScore: 6)
Acta Poética     Open Access   (Followers: 4, SJR: 0.101, CiteScore: 0)
Acta Psychologica     Hybrid Journal   (Followers: 27, SJR: 1.331, CiteScore: 2)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.052, CiteScore: 2)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3, SJR: 0.374, CiteScore: 1)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.344, CiteScore: 1)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 1)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 6, SJR: 0.19, CiteScore: 0)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 3)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 6)
Acute Pain     Full-text available via subscription   (Followers: 15, SJR: 2.671, CiteScore: 5)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.53, CiteScore: 4)
Addictive Behaviors     Hybrid Journal   (Followers: 16, SJR: 1.29, CiteScore: 3)
Addictive Behaviors Reports     Open Access   (Followers: 8, SJR: 0.755, CiteScore: 2)
Additive Manufacturing     Hybrid Journal   (Followers: 9, SJR: 2.611, CiteScore: 8)
Additives for Polymers     Full-text available via subscription   (Followers: 22)
Advanced Cement Based Materials     Full-text available via subscription   (Followers: 3, SJR: 0.732, CiteScore: 3)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 134, SJR: 4.09, CiteScore: 13)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.167, CiteScore: 4)
Advanced Powder Technology     Hybrid Journal   (Followers: 16, SJR: 0.694, CiteScore: 3)
Advances in Accounting     Hybrid Journal   (Followers: 8, SJR: 0.277, CiteScore: 1)
Advances in Agronomy     Full-text available via subscription   (Followers: 12, SJR: 2.384, CiteScore: 5)
Advances in Anesthesia     Full-text available via subscription   (Followers: 28, SJR: 0.126, CiteScore: 0)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 2)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 10, SJR: 0.992, CiteScore: 1)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 10, SJR: 1.551, CiteScore: 4)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 22, SJR: 2.089, CiteScore: 5)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 14, SJR: 0.572, CiteScore: 2)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.61, CiteScore: 7)
Advances in Botanical Research     Full-text available via subscription   (Followers: 2, SJR: 0.686, CiteScore: 2)
Advances in Cancer Research     Full-text available via subscription   (Followers: 29, SJR: 3.043, CiteScore: 6)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 7, SJR: 1.453, CiteScore: 2)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 1.992, CiteScore: 5)
Advances in Cell Aging and Gerontology     Full-text available via subscription   (Followers: 3)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 27, SJR: 0.156, CiteScore: 1)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.713, CiteScore: 1)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 10, SJR: 1.316, CiteScore: 2)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28, SJR: 1.562, CiteScore: 3)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 19, SJR: 1.977, CiteScore: 8)
Advances in Computers     Full-text available via subscription   (Followers: 14, SJR: 0.205, CiteScore: 1)
Advances in Dermatology     Full-text available via subscription   (Followers: 15)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 11)
Advances in Digestive Medicine     Open Access   (Followers: 8)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 23)
Advances in Ecological Research     Full-text available via subscription   (Followers: 42, SJR: 2.524, CiteScore: 4)
Advances in Engineering Software     Hybrid Journal   (Followers: 27, SJR: 1.159, CiteScore: 4)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 7)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 43, SJR: 5.39, CiteScore: 8)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 1)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 9)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 53, SJR: 0.591, CiteScore: 2)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 17)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 1.354, CiteScore: 4)
Advances in Genome Biology     Full-text available via subscription   (Followers: 8, SJR: 12.74, CiteScore: 13)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 1.193, CiteScore: 3)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 21, SJR: 0.368, CiteScore: 1)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 11, SJR: 0.749, CiteScore: 3)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 22)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.193, CiteScore: 0)
Advances in Immunology     Full-text available via subscription   (Followers: 37, SJR: 4.433, CiteScore: 6)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 1.163, CiteScore: 2)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 2, SJR: 1.938, CiteScore: 3)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6, SJR: 0.176, CiteScore: 0)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 3)
Advances in Life Course Research     Hybrid Journal   (Followers: 8, SJR: 0.682, CiteScore: 2)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Marine Biology     Full-text available via subscription   (Followers: 14, SJR: 0.88, CiteScore: 2)
Advances in Mathematics     Full-text available via subscription   (Followers: 11, SJR: 3.027, CiteScore: 2)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6, SJR: 0.694, CiteScore: 2)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.158, CiteScore: 3)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 21)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 8)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.182, CiteScore: 0)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 3)
Advances in Oncobiology     Full-text available via subscription   (Followers: 1)
Advances in Organ Biology     Full-text available via subscription   (Followers: 1)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 16, SJR: 1.875, CiteScore: 4)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 6, SJR: 0.174, CiteScore: 0)
Advances in Parasitology     Full-text available via subscription   (Followers: 5, SJR: 1.579, CiteScore: 4)
Advances in Pediatrics     Full-text available via subscription   (Followers: 24, SJR: 0.461, CiteScore: 1)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 10)
Advances in Pharmacology     Full-text available via subscription   (Followers: 16, SJR: 1.536, CiteScore: 3)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.574, CiteScore: 1)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.109, CiteScore: 1)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 19, SJR: 0.791, CiteScore: 2)
Advances in Psychology     Full-text available via subscription   (Followers: 59)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 6, SJR: 0.371, CiteScore: 1)
Advances in Radiation Oncology     Open Access   (SJR: 0.263, CiteScore: 1)
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.101, CiteScore: 0)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 5)
Advances in Space Research     Full-text available via subscription   (Followers: 385, SJR: 0.569, CiteScore: 2)
Advances in Structural Biology     Full-text available via subscription   (Followers: 5)
Advances in Surgery     Full-text available via subscription   (Followers: 10, SJR: 0.555, CiteScore: 2)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 29, SJR: 2.208, CiteScore: 4)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 17)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 2.262, CiteScore: 5)
Advances in Water Resources     Hybrid Journal   (Followers: 46, SJR: 1.551, CiteScore: 3)
Aeolian Research     Hybrid Journal   (Followers: 6, SJR: 1.117, CiteScore: 3)
Aerospace Science and Technology     Hybrid Journal   (Followers: 335, SJR: 0.796, CiteScore: 3)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.42, CiteScore: 2)
African J. of Emergency Medicine     Open Access   (Followers: 6, SJR: 0.296, CiteScore: 0)
Ageing Research Reviews     Hybrid Journal   (Followers: 10, SJR: 3.671, CiteScore: 9)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 436, SJR: 1.238, CiteScore: 3)
Agri Gene     Hybrid Journal   (SJR: 0.13, CiteScore: 0)
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 1.818, CiteScore: 5)
Agricultural Systems     Hybrid Journal   (Followers: 31, SJR: 1.156, CiteScore: 4)
Agricultural Water Management     Hybrid Journal   (Followers: 43, SJR: 1.272, CiteScore: 3)
Agriculture and Agricultural Science Procedia     Open Access   (Followers: 1)
Agriculture and Natural Resources     Open Access   (Followers: 2)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 56, SJR: 1.747, CiteScore: 4)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.589, CiteScore: 3)
Air Medical J.     Hybrid Journal   (Followers: 6, SJR: 0.26, CiteScore: 0)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.19, CiteScore: 0)
Alcohol     Hybrid Journal   (Followers: 11, SJR: 1.153, CiteScore: 3)
Alcoholism and Drug Addiction     Open Access   (Followers: 9)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.604, CiteScore: 3)
Alexandria J. of Medicine     Open Access   (Followers: 1, SJR: 0.191, CiteScore: 1)
Algal Research     Partially Free   (Followers: 10, SJR: 1.142, CiteScore: 4)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.504, CiteScore: 1)
Allergology Intl.     Open Access   (Followers: 5, SJR: 1.148, CiteScore: 2)
Alpha Omegan     Full-text available via subscription   (SJR: 3.521, CiteScore: 6)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 9, SJR: 0.201, CiteScore: 1)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 50, SJR: 4.66, CiteScore: 10)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 4, SJR: 1.796, CiteScore: 4)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 4, SJR: 1.108, CiteScore: 3)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 6)
American Heart J.     Hybrid Journal   (Followers: 50, SJR: 3.267, CiteScore: 4)
American J. of Cardiology     Hybrid Journal   (Followers: 51, SJR: 1.93, CiteScore: 3)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 44, SJR: 0.604, CiteScore: 1)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 10)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.524, CiteScore: 3)
American J. of Human Genetics     Hybrid Journal   (Followers: 32, SJR: 7.45, CiteScore: 8)
American J. of Infection Control     Hybrid Journal   (Followers: 26, SJR: 1.062, CiteScore: 2)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 34, SJR: 2.973, CiteScore: 4)
American J. of Medicine     Hybrid Journal   (Followers: 43)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3, SJR: 1.967, CiteScore: 2)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 203, SJR: 2.7, CiteScore: 4)
American J. of Ophthalmology     Hybrid Journal   (Followers: 62, SJR: 3.184, CiteScore: 4)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 6, SJR: 0.265, CiteScore: 0)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.289, CiteScore: 1)
American J. of Otolaryngology     Hybrid Journal   (Followers: 25, SJR: 0.59, CiteScore: 1)
American J. of Pathology     Hybrid Journal   (Followers: 27, SJR: 2.139, CiteScore: 4)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 27, SJR: 2.164, CiteScore: 4)
American J. of Surgery     Hybrid Journal   (Followers: 37, SJR: 1.141, CiteScore: 2)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.767, CiteScore: 1)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 6)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.144, CiteScore: 3)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 63, SJR: 0.138, CiteScore: 0)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 15, SJR: 0.411, CiteScore: 1)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 3, SJR: 0.277, CiteScore: 0)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription  
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 5, SJR: 4.849, CiteScore: 10)
Analytica Chimica Acta     Hybrid Journal   (Followers: 39, SJR: 1.512, CiteScore: 5)
Analytical Biochemistry     Hybrid Journal   (Followers: 174, SJR: 0.633, CiteScore: 2)
Analytical Chemistry Research     Open Access   (Followers: 10, SJR: 0.411, CiteScore: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 11)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 2)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 23, SJR: 0.683, CiteScore: 2)
Angiología     Full-text available via subscription   (SJR: 0.121, CiteScore: 0)
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1, SJR: 0.111, CiteScore: 0)

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Journal Cover
Allergology International
Journal Prestige (SJR): 1.148
Citation Impact (citeScore): 2
Number of Followers: 5  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1323-8930 - ISSN (Online) 1440-1592
Published by Elsevier Homepage  [3163 journals]
  • Asthma-chronic obstructive pulmonary disease overlap (ACO): An emerging
           entity in allergic respiratory diseases

    • Authors: Jun Tamaoki; Kenji Izuhara
      Pages: 163 - 164
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Jun Tamaoki, Kenji Izuhara


      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.03.001
       
  • Therapeutic approaches of asthma and COPD overlap

    • Authors: Mitsuko Kondo; Jun Tamaoki
      Pages: 187 - 190
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Mitsuko Kondo, Jun Tamaoki
      Asthma and COPD overlap (ACO) is an important clinical phenotype, due to the low-health-related quality of life (QOL), rapid decline in lung function, frequent exacerbation, and high economic burden. However, no large-scaled therapeutic trials of ACO have been conducted. At present, ACO is treated according to asthma/COPD guidelines. The goals of ACO treatment are to relieve symptoms and improve QOL and lung functions. Treatment must also prevent disease progression, airway remodeling, exacerbation, complications, and comorbidities. To achieve these goals, ACO needs first to be assessed based on pathophysiological findings. Comprehensive long-term management includes medication, reduction of risk factors, environmental improvement, patient education, rehabilitation, and vaccination. Drug treatment for ACO employs a combination of inhaled corticosteroids (ICSs) and long-acting bronchodilators; long-acting muscarinic antagonists and/or long-acting β2-agonists. The dose of ICS is determined according to ACO severity. Leukotriene receptor antagonists and theophylline are used as add-on drugs. Macrolides and expectorants are recommended for reduction of mucus hypersecretion. Anti-IgE and anti–IL-5 antibodies, oral corticosteroids, and oxygen therapy are additional treatments for the most severe ACO. The therapeutic effects are evaluated using lung function tests, eosinophil counts in sputum and blood, FeNO, and symptom questionnaires. ACO exacerbation is treated by inhalation of short-acting β2-agonist and systemic corticosteroids. The doses of corticosteroids are determined based on the asthma/COPD component of the exacerbation. Administration of antibiotics is recommended if sputum is purulent. Referral to specialists is necessary in cases of inability to control symptoms by medication, uncertain diagnosis with atypical features, or severe complications and comorbidities.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.09.002
       
  • Chronic spontaneous urticaria and the extrinsic coagulation system

    • Authors: Yuhki Yanase; Shunsuke Takahagi; Michihiro Hide
      Pages: 191 - 194
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Yuhki Yanase, Shunsuke Takahagi, Michihiro Hide
      Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch. Recently, the activation of the blood coagulation cascade has been suggested to be involved in CSU, but the trigger of the coagulation cascade remains unclear. In this article, we review recent understanding of the relationship between the pathogenesis of CSU and extrinsic coagulation reactions. In CSU, vascular endothelial cells and eosinophils may play a role as TF-expressing cells for activating the extrinsic coagulation pathway. Moreover, the expression of TF on endothelial cells is synergistically enhanced by the activation of Toll-like receptors and histamine H1 receptors. The activated coagulation factors may induce plasma extravasation followed by degranulation of skin mast cells and edema formation recognized as wheal in CSU. Molecules involved in this cascade could be a target for new and more effective treatments of urticaria.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.09.003
       
  • An analysis of factors related to the effect of sublingual immunotherapy
           on Japanese cedar pollen induced allergic rhinitis

    • Authors: Syuji Yonekura; Yoshitaka Okamoto; Daiju Sakurai; Kimihiro Okubo; Minoru Gotoh; Shinya Kaneko; Akiyoshi Konno
      Pages: 201 - 208
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Syuji Yonekura, Yoshitaka Okamoto, Daiju Sakurai, Kimihiro Okubo, Minoru Gotoh, Shinya Kaneko, Akiyoshi Konno
      Background Sublingual immunotherapy (SLIT) can improve the symptoms of allergic rhinitis and modify its natural history; however, its efficacy varies among patients. This study aimed to determine which factors modify the effect of SLIT through post hoc analysis of a previous phase 3 trial of standardized Japanese cedar (JC) pollen extract (CEDARTOLEN®). Methods The study included 482 patients who had previously completed a phase 3 trial during two seasons. The SLIT and placebo groups each contained 241 subjects. Because pollen dispersal differed in the two seasons, we identified good and poor responders from the SLIT group in the 2nd season. We compared patient baseline characteristics, changes in serum immunoglobulin, and severity of symptoms in the 1st season between good and poor responders, as well as between SLIT and placebo groups. Results When we compared the baseline characteristics of good and poor responders, a significant difference was observed in body mass index (BMI) such that the patients with BMI ≥25 presented with lower treatment efficacy. No significant difference was observed in correlation with any other factors or treatment-induced alterations of serum immunoglobulin levels. We found that 75.3% of the patients with moderate symptoms and 50.9% of the patients with severe or very severe symptoms in the 1st season met our criteria for good responders in the 2nd season. Conclusions BMI might modify the effect of SLIT; however, other factors were not related clearly. The severity of symptoms in the 1st season of treatment does not predict that in the 2nd season.
      Graphical abstract image

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.07.005
       
  • Desensitization to a whole egg by rush oral immunotherapy improves the
           quality of life of guardians: A multicenter, randomized, parallel-group,
           delayed-start design study

    • Authors: Naoka Itoh-Nagato; Yuzaburo Inoue; Mizuho Nagao; Takao Fujisawa; Naoki Shimojo; Tsutomu Iwata; Yuichi Adachi; Koichi Arakawa; Takayasu Arima; Keitaro Fukushima; Akira Hoshioka; Takashi Igarashi; Toshiko Itazawa; Komei Itoh; Makoto Kameda; Naoyuki Kando; Izumi Kato; Taeru Kitabayashi; Takae Kobayashi; Harumi Koyama; Yoshinori Morita; Taiji Nakano; Shuichi Suzuki; Yuri Takaoka; Minako Tomiita; Hisako Yagi; Yuko Yajima; Akiko Yamaide; Masahiro Yasui; Shigemi Yoshihara
      Pages: 209 - 216
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Naoka Itoh-Nagato, Yuzaburo Inoue, Mizuho Nagao, Takao Fujisawa, Naoki Shimojo, Tsutomu Iwata
      Background Patients with food allergies and their families have a significantly reduced health-related quality of life (QOL). Methods We performed a multicenter, randomized, parallel-group, delayed-start design study to clarify the efficacy and safety of rush oral immunotherapy (rOIT) and its impact on the participants' daily life and their guardians (UMIN000003943). Forty-five participants were randomly divided into an early-start group and a late-start group. The early-start group received rOIT for 3 months, while the late-start group continued the egg elimination diet (control). In the next stage, both groups received OIT until all participants had finished 12 months of maintenance OIT. Results The ratio of the participants in whom an increase of the TD was achieved in the first stage was significantly higher in the early-start group (87.0%), than in the late-start group (22.7%). The QOL of the guardians in the early-start group significantly improved after the first stage (65.2%), in comparison to the late-start group (31.8%). During 12 months of rOIT, the serum ovomucoid-specific IgE levels, the percentage of CD203c+ basophils upon stimulation with egg white, and the wheal size to egg white were decreased, while the serum ovomucoid-specific IgG4 levels were increased. However, approximately 80% of the participants in the early-start group showed an allergic reaction during the first stage of the study, whereas none of the patients in the late-start group experienced an allergic reaction. Conclusions rOIT induced desensitization to egg and thus improved the QOL of guardians; however, the participants experienced frequent allergic reactions due to the treatment.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.07.007
       
  • Hand eczema as a risk factor for food allergy among occupational kitchen
           workers

    • Authors: Takafumi Minami; Yuma Fukutomi; Kiyoshi Sekiya; Akira Akasawa; Masami Taniguchi
      Pages: 217 - 224
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Takafumi Minami, Yuma Fukutomi, Kiyoshi Sekiya, Akira Akasawa, Masami Taniguchi
      Background An increasing number of studies in children is highlighting the importance of transdermal routes of exposure to food allergens through damaged skin in the pathogenesis of food allergies. However, data on this in adults are limited. A few case-series studies has documented development of food allergy among kitchen workers with hand eczema after direct contact exposure to foods. Methods To explore the significance of hand eczema as a risk factor for food allergies in adults at the epidemiological level, we performed a cross-sectional web-based questionnaire survey on kitchen workers whose exposures were classed as occupational (cooks and food handlers, n = 1592) or non-occupational (housewives, n = 1915). Logistic regression was used to explore the association between the presence/severity of hand eczema and the risk of food allergy after adjustment for potential confounders. Results Current hand eczema and current diagnosed food allergy were more common among occupational kitchen workers (OKW) than among non-occupational kitchen workers (NOKW) (32.3%-vs-29.9% and 9.9%-vs-3.8%, respectively). Current hand eczema was significantly associated with increased risk of current diagnosed food allergy in OKW (adjusted odds ratio 2.4, 95% CI 1.6–3.7). Those with more severe hand eczema were more likely to suffer from allergic symptoms for foods, and diagnosed food allergy. Conclusions This study illustrates a significant public health problem in the adult population, documenting a major impact of hand eczema on the ongoing adult food allergy epidemic.
      Graphical abstract image

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.08.005
       
  • Exposure amount and timing of solar irradiation during pregnancy and the
           risk of sensitization in children

    • Authors: Hyun Yong Koh; Eunhae Cho; So-Yeon Lee; Woo Kyung Kim; Yong Mean Park; Jihyun Kim; Kangmo Ahn; Seung Won Lee; Mi Ae Kim; Myung-Il Hahm; Yoomi Chae; Kee-Jae Lee; Ho-Jang Kwon; Man Yong Han
      Pages: 225 - 233
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Hyun Yong Koh, Eunhae Cho, So-Yeon Lee, Woo Kyung Kim, Yong Mean Park, Jihyun Kim, Kangmo Ahn, Seung Won Lee, Mi Ae Kim, Myung-Il Hahm, Yoomi Chae, Kee-Jae Lee, Ho-Jang Kwon, Man Yong Han
      Background Solar irradiation affects sensitization to aeroallergens and the prevalence of allergic diseases. Little is known, however, about how the time and amount of solar irradiation during pregnancy affects such risks in children. We aimed to find out how solar irradiation during pregnancy affects sensitization to aero-allergens and the prevalence of allergic diseases in children. Methods This population-based cross-sectional study involved 7301 aged 6 years and aged 12 years children. Maternal exposure to solar irradiation during pregnancy was evaluated using data from weather stations closest to each child's birthplace. Monthly average solar irradiation during the second and third trimesters was calculated with rank by quartiles. Risks of allergic sensitization and allergic disease were estimated. Results Relative to the first (lowest) quartile, the adjusted odds ratio (aOR) for allergic sensitization in the fourth (highest) quartile was lowest within solar irradiation during pregnancy months 5–6 (aOR = 0.823, 95% CI 0.720–0.942, p < 0.05). During months 9–10, the aOR for allergic sensitization for the fourth was higher than the first quartile of solar irradiation (aOR = 1.167, 95% CI 1.022–1.333, p < 0.05). Similar results were observed when solar irradiation was analyzed as a continuous variable during months 5 (aOR = 0.975, 95% CI 0.962–0.989, p < 0.001) and month 9 (aOR = 1.018, 95% CI 1.004–1.031, p = 0.003). Increased solar irradiation during months 7–8 increased the risk of asthma (aOR = 1.309, 95% CI 1.024–1.674, p = 0.032). Conclusions Maternal exposure to solar irradiation during the second trimester of pregnancy associated with reduced aeroallergen sensitization, whereas solar irradiation during the third trimester was related to increased sensitization to aeroallergens.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.08.007
       
  • Mast cells derived from human induced pluripotent stem cells are useful
           for allergen tests

    • Authors: Akira Igarashi; Yasuhiro Ebihara; Tomoaki Kumagai; Hiroyuki Hirai; Kinya Nagata; Kohichiro Tsuji
      Pages: 234 - 242
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Akira Igarashi, Yasuhiro Ebihara, Tomoaki Kumagai, Hiroyuki Hirai, Kinya Nagata, Kohichiro Tsuji
      Background Several methods have been developed to detect allergen-specific IgE in sera. The passive IgE sensitization assay using human IgE receptor-expressing rat cell line RBL-2H3 is a powerful tool to detect biologically active allergen-specific IgE in serum samples. However, one disadvantage is that RBL-2H3 cells are vulnerable to high concentrations of human sera. Only a few human cultured cell lines are easily applicable to the passive IgE sensitization assay. However, the use of human induced pluripotent stem cells (iPSCs) to generate human mast cells (MCs) has not yet been reported. Methods The nuclear factor-kappa B (NF-κB)-responsive luciferase reporter gene was stably introduced into a human iPSC line 201B7, and the transfectants were induced to differentiate into MCs (iPSC-MCs). The iPSC-MCs were sensitized overnight with sera from subjects who were allergic to cedar pollen, ragweed pollen, mites, or house dust, and then stimulated with an extract of corresponding allergens. Activation of iPSC-MCs was evaluated by β-hexosaminidase release, histamine release, or luciferase intensity. Results iPSCs-MCs stably expressed high-affinity IgE receptor and functionally responded to various allergens when sensitized with human sera from relevant allergic subjects. This passive IgE sensitization system, which we termed the induced mast cell activation test (iMAT), worked well even with undiluted human sera. Conclusions iMAT may serve as a novel determining system for IgE/allergens in the clinical and research settings.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.08.008
       
  • Efficacy and safety of omalizumab for the treatment of refractory chronic
           spontaneous urticaria in Japanese patients: Subgroup analysis of the phase
           3 POLARIS study

    • Authors: Michihiro Hide; Atsuyuki Igarashi; Akiko Yagami; Yuko Chinuki; Naoko Inomata; Atsushi Fukunaga; Guenther Kaiser; Junyi Wang; Soichiro Matsushima; Steven Greenberg; Sam Khalil
      Pages: 243 - 252
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Michihiro Hide, Atsuyuki Igarashi, Akiko Yagami, Yuko Chinuki, Naoko Inomata, Atsushi Fukunaga, Guenther Kaiser, Junyi Wang, Soichiro Matsushima, Steven Greenberg, Sam Khalil
      Background Omalizumab, a humanized anti-IgE monoclonal antibody, proved efficacious and well tolerated in patients with chronic spontaneous urticaria (CSU) refractory to H1 antihistamines (H1AH) in the POLARIS study (NCT02329223), a randomized, double-blind, placebo-controlled trial in East Asian patients. However, data in Japanese patients, who have specific baseline characteristics (e.g., low angioedema incidence, different background medications) that may impact clinical outcomes, are lacking. This pre-specified analysis presents additional patient-level data over time, pharmacokinetic and pharmacodynamics data for omalizumab and IgE, and efficacy and safety data for omalizumab in Japanese patients. Methods Japanese patients (N = 105) were randomized 1:1:1 to omalizumab 300 mg, 150 mg, or placebo by subcutaneous injection every 4 weeks. Efficacy and safety were assessed primarily based on changes from baseline to Week 12 in weekly itch-severity scores (ISS7) and weekly urticaria activity scores (UAS7), and incidence of adverse events (AEs), respectively. Patient-level UAS7 data over time were also reviewed. Results At Week 12, least squares mean (LSM) changes from baseline in ISS7 were greater with omalizumab vs. placebo (−9.54 and −7.29 for omalizumab 300 mg and 150 mg, respectively, vs. placebo [−5.17]). Corresponding LSM changes from baseline in UAS7 were −21.61 and −15.59 (vs. placebo [−10.88]). Most responders in the omalizumab 300 mg group displayed improvement of disease activity within 2–4 weeks and had well-controlled symptoms during the treatment period. Overall AE incidence was similar across treatment arms. Conclusions This subgroup analysis demonstrated that omalizumab is a well-tolerated, beneficial option for treatment of CSU in H1AH-refractory Japanese patients.
      Graphical abstract image

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.10.001
       
  • Phenotype classification using the combination of lung sound analysis and
           fractional exhaled nitric oxide for evaluating asthma treatment

    • Authors: Terufumi Shimoda; Yasushi Obase; Yukio Nagasaka; Sadahiro Asai
      Pages: 253 - 258
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Terufumi Shimoda, Yasushi Obase, Yukio Nagasaka, Sadahiro Asai
      Background We report the utility of combining lung sound analysis and fractional exhaled nitric oxide (FeNO) for phenotype classification of airway inflammation in patients with bronchial asthma. We investigated the usefulness of the combination of the expiration-to-inspiration sound power ratio in the mid-frequency range (E/I MF) of 200–400 Hz and FeNO for comprehensively classifying disease type and evaluating asthma treatment. Methods A total of 233 patients with bronchial asthma were included. The cutoff values of FeNO and E/I MF were set to 38 ppb and 0.36, respectively, according to a previous study. The patients were divided into 4 subgroups based on the FeNO and E/I MF cutoff values. Respiratory function, the percentages of sputum eosinophils and neutrophils, and patient background characteristics were compared among groups. Results Respiratory function was well controlled in the FeNO low/E/I MF low group (good control). Sputum neutrophil was higher and FEV1,%pred was lower in the FeNO low/E/I MF high group (poor control). History of childhood asthma and atopic asthma were associated with the FeNO high/E/I MF low group (insufficient control). The FeNO high/E/I MF high group corresponded to a longer disease duration, increased blood or sputum eosinophils, and lower FEV1/FVC (poor control). Conclusions The combination of FeNO and E/I MF assessed by lung sound analysis allows the condition of airway narrowing and the degree of airway inflammation to be assessed in patients with asthma and is useful for evaluating bronchial asthma treatments.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.09.004
       
  • Up-regulation of serum periostin and squamous cell carcinoma antigen
           levels in infants with acute bronchitis due to respiratory syncytial virus
           

    • Authors: Hiroaki Nakamura; Kenichi Akashi; Masako Watanabe; Shoichiro Ohta; Junya Ono; Yoshinori Azuma; Noriko Ogasawara; Keisuke Yamamoto; Norikazu Shimizu; Hiroyuki Tsutsumi; Kenji Izuhara; Toshio Katsunuma
      Pages: 259 - 265
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Hiroaki Nakamura, Kenichi Akashi, Masako Watanabe, Shoichiro Ohta, Junya Ono, Yoshinori Azuma, Noriko Ogasawara, Keisuke Yamamoto, Norikazu Shimizu, Hiroyuki Tsutsumi, Kenji Izuhara, Toshio Katsunuma
      Background Periostin and squamous cell carcinoma antigen (SCCA) are involved in the pathogenesis of asthma. Acute bronchitis due to respiratory syncytial virus (RSV) infection during infancy exhibits an asthma-like pathogenesis, suggesting that it may be associated with the subsequent development of asthma. However, the mechanism by which RSV infection leads to development of asthma has not yet been fully elucidated. Methods Infants younger than 36 months were enrolled and classified into three groups. Group I included patients hospitalized with RSV-induced bronchitis. These patients were further stratified into two sub-groups according to whether the criteria for the modified Asthma Predictive Index (mAPI) had been met: Group I consisted of mAPI (+) and mAPI (−) patients; Group II included patients with food allergy as a positive control group; and Group III included children with no allergy as a negative control group. Serum periostin and SCCA levels were measured in the groups. This study was registered as a clinical trial (UMIN000012339). Results We enrolled 14 subjects in Group I mAPI (+), 22 in Group I mAPI (−), 18 in Group II, and 18 in Group III. In Group I, the serum periostin and SCCA levels were significantly higher during the acute phase compared with the recovery phase. However, no significant differences were found between Group I mAPI (+) and mAPI (−). Conclusions The serum periostin and SCCA levels increased during acute RSV bronchitis. Both periostin and SCCA may play a role in the pathogenesis of acute bronchitis due to RSV.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.10.003
       
  • Efficacy and safety of benralizumab in Japanese patients with severe,
           uncontrolled eosinophilic asthma

    • Authors: Ken Ohta; Mitsuru Adachi; Yuji Tohda; Tadashi Kamei; Motokazu Kato; J. Mark Fitzgerald; Masayuki Takanuma; Tadahiro Kakuno; Nobuyuki Imai; Yanping Wu; Magnus Aurivillius; Mitchell Goldman
      Pages: 266 - 272
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Ken Ohta, Mitsuru Adachi, Yuji Tohda, Tadashi Kamei, Motokazu Kato, J. Mark Fitzgerald, Masayuki Takanuma, Tadahiro Kakuno, Nobuyuki Imai, Yanping Wu, Magnus Aurivillius, Mitchell Goldman
      Background In the Phase III CALIMA trial, benralizumab significantly reduced asthma exacerbations, increased lung function, and alleviated symptoms for patients with severe, uncontrolled eosinophilic asthma. The aim of this subgroup analysis was to evaluate the efficacy and safety of benralizumab for Japanese patients in the CALIMA trial. Methods CALIMA was a randomised, controlled trial of 1306 patients (aged 12–75 years; registered at ClinicalTrials.gov: NCT01914757) with severe asthma uncontrolled by medium- to high-dosage inhaled corticosteroids and long-acting β2-agonists (ICS/LABA). Patients received 56 weeks' benralizumab 30 mg either every 4 weeks (Q4W) or every 8 weeks (Q8W; first three doses Q4W), or placebo Q4W. The primary analysis population was patients receiving high-dosage ICS/LABA with blood eosinophils ≥300 cells/μL. This subgroup analysis covered Japanese patients from this group. Results Of 83 patients randomised in Japan, 46 were receiving high-dosage ICS/LABA and had blood eosinophils ≥300 cells/μL. Compared with placebo, benralizumab reduced the annual rate of asthma exacerbations by 66% (Q4W; rate ratio 0.34, 95% CI, 0.11–0.99) and 83% (Q8W; rate ratio 0.17, 95% CI, 0.05–0.60); increased prebronchodilator FEV1 by 0.334 L (Q4W; 95% CI, 0.020–0.647) and 0.198 L (Q8W; 95% CI, −0.118 to 0.514); and decreased total asthma symptom score by 0.17 (Q4W; 95% CI, −0.82 to 0.48) and 0.24 (Q8W; 95% CI, −0.87 to 0.40). Percentages of adverse events were consistent with the overall CALIMA group. Conclusions Benralizumab reduced annual asthma exacerbations and symptoms, increased lung function, and was well-tolerated by Japanese patients with severe, uncontrolled eosinophilic asthma.
      Graphical abstract image

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.10.004
       
  • Bronchial thermoplasty for severe uncontrolled asthma in Japan

    • Authors: Motoyasu Iikura; Masayuki Hojo; Naoko Nagano; Keita Sakamoto; Konomi Kobayashi; Shota Yamamoto; Masao Hashimoto; Satoru Ishii; Shinyu Izumi; Haruhito Sugiyama
      Pages: 273 - 275
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Motoyasu Iikura, Masayuki Hojo, Naoko Nagano, Keita Sakamoto, Konomi Kobayashi, Shota Yamamoto, Masao Hashimoto, Satoru Ishii, Shinyu Izumi, Haruhito Sugiyama


      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.07.006
       
  • Urticaria by thiamine (vitamin B1)

    • Authors: Ana Rodríguez-Fernández; Marcos Sánchez-Domínguez; Blanca Noguerado-Mellado; Patricia Rojas-Pérez-Ezquerra
      Pages: 276 - 277
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Ana Rodríguez-Fernández, Marcos Sánchez-Domínguez, Blanca Noguerado-Mellado, Patricia Rojas-Pérez-Ezquerra


      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.07.008
       
  • Omalizumab for hypersensitive reaction to seminal plasma: A case report

    • Authors: Maria Teresa Burguete-Cabanas; Oscar R. Fajardo-Ramirez; Roberta Yesaki; Raul Estrada-Maganas; Sandra Salazar-Meza; Olga Rios-Chavez; Irene Meester; Julio C. Salas-Alanis
      Pages: 278 - 279
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Maria Teresa Burguete-Cabanas, Oscar R. Fajardo-Ramirez, Roberta Yesaki, Raul Estrada-Maganas, Sandra Salazar-Meza, Olga Rios-Chavez, Irene Meester, Julio C. Salas-Alanis


      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.07.009
       
  • Mucus plugging in allergic bronchopulmonary aspergillosis: Implication of
           the eosinophil DNA traps

    • Authors: Ayumi Omokawa; Shigeharu Ueki; Yuta Kikuchi; Masahide Takeda; Mariko Asano; Kazuhiro Sato; Masaaki Sano; Hiroshi Ito; Makoto Hirokawa
      Pages: 280 - 282
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Ayumi Omokawa, Shigeharu Ueki, Yuta Kikuchi, Masahide Takeda, Mariko Asano, Kazuhiro Sato, Masaaki Sano, Hiroshi Ito, Makoto Hirokawa


      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.08.002
       
  • Long-term course of serum total and free IgE levels in severe asthma
           patients treated with omalizumab

    • Authors: Yasuhiro Gon; Reiko Ito; Shuichiro Maruoka; Kenji Mizumura; Yutaka Kozu; Hisato Hiranuma; Yuko Iida; Mari Hikichi; Sotaro Shikano; Shu Hashimoto
      Pages: 283 - 285
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Yasuhiro Gon, Reiko Ito, Shuichiro Maruoka, Kenji Mizumura, Yutaka Kozu, Hisato Hiranuma, Yuko Iida, Mari Hikichi, Sotaro Shikano, Shu Hashimoto


      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.08.003
       
  • A case of clinically amyopathic dermatomyositis that developed during
           anti-TNF-α therapy for rheumatoid arthritis

    • Authors: Miki Takata; Akira Yamasaki; Nanako Yamada; Hiroshi Hagino; Yoshihiro Funaki; Tomoya Harada; Ryota Okazaki; Yasuyuki Hasegawa; Takehito Fukushima; Masato Morita; Yuriko Sueda; Akihiro Yamamoto; Eiji Shimizu
      Pages: 286 - 288
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Miki Takata, Akira Yamasaki, Nanako Yamada, Hiroshi Hagino, Yoshihiro Funaki, Tomoya Harada, Ryota Okazaki, Yasuyuki Hasegawa, Takehito Fukushima, Masato Morita, Yuriko Sueda, Akihiro Yamamoto, Eiji Shimizu


      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.09.001
       
  • Vitamin D deficiency exacerbates sensitization and allergic diarrhea in a
           murine food allergy model

    • Authors: Teruaki Matsui; Hirotaka Yamashita; Ken-ichi Saneyasu; Hiroyuki Tanaka; Komei Ito; Naoki Inagaki
      Pages: 289 - 291
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Teruaki Matsui, Hirotaka Yamashita, Ken-ichi Saneyasu, Hiroyuki Tanaka, Komei Ito, Naoki Inagaki


      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.08.010
       
  • How important is allergic sensitization as a cause of atopic asthma'

    • Authors: Jun Kanazawa; Hironori Masuko; Hideyasu Yamada; Yohei Yatagai; Tohru Sakamoto; Haruna Kitazawa; Hiroaki Iijima; Takashi Naito; Tomomitsu Hirota; Mayumi Tamari; Nobuyuki Hizawa
      Pages: 292 - 294
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Jun Kanazawa, Hironori Masuko, Hideyasu Yamada, Yohei Yatagai, Tohru Sakamoto, Haruna Kitazawa, Hiroaki Iijima, Takashi Naito, Tomomitsu Hirota, Mayumi Tamari, Nobuyuki Hizawa


      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.10.005
       
  • An independent relation of atopic dermatitis to exercise-induced wheezing
           in asthmatic children

    • Authors: Satoshi Honjo; Yoko Murakami; Hiroshi Odajima; Yuichi Adachi; Koichi Yoshida; Yukihiro Ohya; Akira Akasawa
      Abstract: Publication date: Available online 30 May 2018
      Source:Allergology International
      Author(s): Satoshi Honjo, Yoko Murakami, Hiroshi Odajima, Yuichi Adachi, Koichi Yoshida, Yukihiro Ohya, Akira Akasawa
      Background Atopic dermatitis (AD) and exercise-induced asthma (EIA) are common in asthmatic children, and exercise is the most common trigger other than infection for acute onset asthma attack in children. We examined whether AD is related to exercise-induced wheezing (EIW), some proxy for EIA. Methods Japanese version of the International Study of Asthma and Allergies in Childhood questionnaires were used. For 12,405 asthmatic school children, AD was defined as itchy rash coming and going for at least 6 months at any time in the last 12 months with affecting places of flexural parts of body, and severity of AD was rated according to frequency of being kept awake at night with the itch as follows: never in the past 12 months, less than one night per week and one or more nights per week. Results Adjusted for frequency of asthma attack, odds ratios (OR) of children with current AD as compared to those without AD for having EIW were 1.32 (95% confidence interval = 1.15–1.52), 1.35 (1.14–1.68) and 1.10 (0.92–1.31) for primary school, junior high school and high school children, respectively. EIW was more likely observed in accordance with increasing severity of AD in the primary school children with ORs of 1.12, 1.59 and 1.54 (p for trend < 0.01), and in the junior high school ones with ORs of 1.18, 1.31, 2.03 (<0.01), respectively. Conclusions AD may be possibly related to EIW. Further studies investigating effect of AD treatment on EIW may be required.

      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.04.013
       
  • A breath sound analysis in children with cough variant asthma

    • Authors: Mayumi Enseki; Mariko Nukaga; Hiromi Tadaki; Hideyuki Tabata; Kota Hirai; Masahiko Kato; Hiroyuki Mochizuki
      Abstract: Publication date: Available online 29 May 2018
      Source:Allergology International
      Author(s): Mayumi Enseki, Mariko Nukaga, Hiromi Tadaki, Hideyuki Tabata, Kota Hirai, Masahiko Kato, Hiroyuki Mochizuki
      Background Cough variant asthma (CVA) is characterized by a chronic cough and bronchial hyperresponsiveness without confirmation of wheezing. Using a breath sound analyzer, we evaluate the characteristics of breath sound in children with CVA. Methods Nine children with CVA (median age, 7.0 years) participated. The existence of breath sounds was confirmed by sound spectrogram. Breath sound parameters, the frequency limiting 50% and 99% of the power spectrum (F50 and F99), the roll-off from 600 to 1200 Hz (Slope) and spectrum curve indices, the ratio of the third and fourth area to the total area of the power spectrum (P3/PT and P4/PT) and the ratio of power and frequency at 50% and 75% of the highest frequency of the power spectrum (RPF75 and RPF50) were calculated before and after β2 agonist inhalation. A spirogram and/or forced oscillation technique were performed in all subjects. Results On a sound spectrogram, wheezing was confirmed in seven of nine patients. All wheezing on the image was polyphonic, and they almost disappeared after β2 agonist inhalation. An analysis of the breath sound spectrum showed that PT, P3/PT, P4/PT, RPF50 and RPF75 were significantly increased after β2 agonist inhalation. Conclusions Children with CVA showed a high rate of inaudible wheezing that disappeared after β2 agonist inhalation. Changes in the spectrum curve indices also indicated the bronchial reversibility. These results may suggest the characteristics of CVA in children.

      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.05.003
       
  • Current status of sublingual immunotherapy for allergic rhinitis
           in Japan

    • Authors: Keisuke Masuyama; Tomokazu Matsuoka; Atsushi Kamijo
      Abstract: Publication date: Available online 25 May 2018
      Source:Allergology International
      Author(s): Keisuke Masuyama, Tomokazu Matsuoka, Atsushi Kamijo
      Japanese cedar pollen (JCP) and house dust mite (HDM) are two major allergens that cause allergic rhinitis (AR) in Japan and the prevalence of AR is increasing. Pharmacothearpy is a commonly used treatment, but the level of patient satisfaction is very low. Allergen immunotherapy (AIT) is the only therapeutic modality that provides not only symptom relief but also quality of life improvement that leads to a high rate of satisfaction. In particular, sublingual immunotherapy (SLIT) is a safe and effective treatment for AR. Here we introduce a large-scale double-blind, placebo-controlled trial of SLIT in Japanese patients using JCP droplets or HDM tablets conducted in Japan. The immediate future of SLIT in Japan is also discussed.

      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.04.011
       
  • Quantification of the ω5- and γ-gliadin content in wheat flour and rat
           plasma with an enzyme-linked immunosorbent assay using antibodies specific
           to their IgE-binding epitopes

    • Authors: Tomoharu Yokooji; Hitomi Nouma; Ryohei Ogino; Takanori Taogoshi; Eishin Morita; Hiroaki Matsuo
      Abstract: Publication date: Available online 19 May 2018
      Source:Allergology International
      Author(s): Tomoharu Yokooji, Hitomi Nouma, Ryohei Ogino, Takanori Taogoshi, Eishin Morita, Hiroaki Matsuo


      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.04.012
       
  • Characterization of human decidual mast cells and establishment of a
           culture system

    • Authors: Takayuki Matsuno; Shota Toyoshima; Tomomi Sakamoto-Sasaki; Jun-ichi Kashiwakura; Akira Matsuda; Yasuo Watanabe; Hiromitsu Azuma; Kei Kawana; Tatsuo Yamamoto; Yoshimichi Okayama
      Abstract: Publication date: Available online 18 May 2018
      Source:Allergology International
      Author(s): Takayuki Matsuno, Shota Toyoshima, Tomomi Sakamoto-Sasaki, Jun-ichi Kashiwakura, Akira Matsuda, Yasuo Watanabe, Hiromitsu Azuma, Kei Kawana, Tatsuo Yamamoto, Yoshimichi Okayama
      Background Although rodent decidual mast cells (MCs) reportedly play an important role in implantation and placenta formation, the characterization of human decidual MCs has been not well clarified. The aims of this study were to investigate the distribution and characteristics of MCs in human decidua and to establish a culture system for decidua-derived MCs. Methods Decidual tissues were obtained from patients who underwent a legal elective abortion (6th week to 9th week of pregnancy), and decidual MCs were enzymatically dispersed. Cultured decidua-derived MCs were generated by culturing decidual cells with stem cell factor. An ultrastructural analysis of primary decidual MCs and cultured decidua-derived MCs was performed using a transmission electron microscope. Receptor and protease expression was analyzed using FACS. Histamine released from MCs was measured using enzyme immune assays. Results A larger proportion of tryptase positive(+) MCs in decidua was present on the maternal side. Both enzymatically dispersed decidual MCs and cultured decidua-derived MCs showed an FcεRIα+Kit+tryptase+chymase+ phenotype. Their granules contenting particles exhibited variable amounts of electron-lucent space separating electron-dense particles. Both enzymatically dispersed decidual MCs and cultured decidua-derived MCs released comparable amounts of histamine following FcεRI aggregation. Conclusions The isolation method for MCs from decidua during early pregnancy and the culture system for decidua-derived MCs may enable the roles of decidual MC during pregnancy to be explored.

      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.05.001
       
  • A recurrent case of eosinophilic pneumonia with high IL-25 levels

    • Authors: Masaki Ikeda; Shigeki Katoh; Mikio Oka
      Abstract: Publication date: Available online 18 May 2018
      Source:Allergology International
      Author(s): Masaki Ikeda, Shigeki Katoh, Mikio Oka


      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.03.005
       
  • Eosinophilic vasculitis affecting multiple middle-sized arteries in a
           patient with Kimura's disease: A case report and literature review

    • Authors: Hiroki Furuya; Kei Ikeda; Junya Suzuki; Kazumasa Suzuki; Kaito Nakamura; Shunsuke Furuta; Tomohiro Tamachi; Kotaro Suzuki; Koichi Hirose; Hiroshi Nakajima
      Abstract: Publication date: Available online 17 May 2018
      Source:Allergology International
      Author(s): Hiroki Furuya, Kei Ikeda, Junya Suzuki, Kazumasa Suzuki, Kaito Nakamura, Shunsuke Furuta, Tomohiro Tamachi, Kotaro Suzuki, Koichi Hirose, Hiroshi Nakajima


      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.04.010
       
  • The global development and clinical efficacy of sublingual tablet
           immunotherapy for allergic diseases

    • Authors: Hendrik Nolte; Jennifer Maloney
      Abstract: Publication date: Available online 16 May 2018
      Source:Allergology International
      Author(s): Hendrik Nolte, Jennifer Maloney
      Allergy immunotherapy (AIT) is a treatment option for respiratory allergy that is complementary to pharmacotherapy, with a distinct mechanism of action. Alternative methods to subcutaneous administration of AIT that enable patients to safely self-administer AIT is considered an unmet clinical need. The sublingual immunotherapy tablet (SLIT-tablet) is an orally disintegrating pharmaceutical formulation (oral lyophilisate) containing standardized allergens. SLIT-tablets have been developed for sublingual immunotherapy (SLIT) of cedar-pollen, grass-pollen, ragweed-pollen, tree-pollen, and house dust mite allergies. It is a once-daily tablet treatment to be self-administered after the first dose has been provided under the supervision of a physician with experience in the diagnosis and treatment of allergic diseases. Once the first dose is adequately tolerated, subsequent doses may be self-administered. SLIT-tablets have proven efficacy for allergic rhinitis (AR) with and without conjunctivitis (C) and allergic asthma (AA) in adults, children, and poly-sensitized allergic patients. Meta-analyses indicate that SLIT-tablets have superior or similar efficacy compared with anti-allergic pharmacotherapies for seasonal AR and superior efficacy for perennial AR. SLIT-tablets have also demonstrated clinically relevant improvements of asthma, with significant reductions in the following: daily inhaled corticosteroid use, risk of asthma exacerbations, and asthma symptoms. SLIT-tablets are generally well tolerated, with a low risk of systemic allergic reactions. The most common treatment-related adverse events are mild-moderate oral reactions. Current evidence supports SLIT-tablets to be considered as an alternative or add-on treatment to pharmacotherapy for AR/C and asthma. Future SLIT developments may include early intervention to prevent the development or progression of allergic disease in children.

      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.03.008
       
  • Acquisition of tolerance to egg allergy in a child with repeated
           egg-induced acute pancreatitis

    • Authors: Ken-ichi Nagakura; Noriyuki Yanagida; Sakura Sato; Kiyotake Ogura; Motohiro Ebisawa
      Abstract: Publication date: Available online 10 May 2018
      Source:Allergology International
      Author(s): Ken-ichi Nagakura, Noriyuki Yanagida, Sakura Sato, Kiyotake Ogura, Motohiro Ebisawa


      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.04.004
       
  • Generalized urticaria caused by ingestion of sweet potato cake

    • Authors: David El-Qutob; Fernando Pineda; Isabela Raducan; Miriam Castillo
      Abstract: Publication date: Available online 10 May 2018
      Source:Allergology International
      Author(s): David El-Qutob, Fernando Pineda, Isabela Raducan, Miriam Castillo


      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.04.005
       
  • Immune suppression of food allergy by maternal IgG in murine models

    • Authors: Hirotaka Yamashita; Tadamasa Hayashi; Kenichi Saneyasu; Hiroki Matsuhara; Teruaki Matsui; Hiroyuki Tanaka; Naoki Inagaki
      Abstract: Publication date: Available online 30 April 2018
      Source:Allergology International
      Author(s): Hirotaka Yamashita, Tadamasa Hayashi, Kenichi Saneyasu, Hiroki Matsuhara, Teruaki Matsui, Hiroyuki Tanaka, Naoki Inagaki
      Background Most of the patients develop food allergy early in life. The factors related to parental immune condition might be one of the conceivable causes. Methods We reported murine models of food allergy and oral OVA tolerance. To investigate the influence of parental immune condition on infant food allergy, female and male mice with food allergy or oral tolerance were mated with each other. Results Food allergy was suppressed by decreased IgE production in the offspring of mice with food allergy. On the contrary, anaphylaxis for OVA was induced in the offspring of mice with oral tolerance. The suppression of food allergy being dependent on a maternal factor was revealed in the offspring after cross-mating mice with food allergy and oral tolerance. Because OVA-specific IgG, presumed to be from the allergic mother, was detected in the serum of naïve infants from mothers allergic to food, we assumed that the suppression was dependent on a specific IgG. The serum IgG purified by a G-protein column was administered before OVA sensitization in the food allergy model, and OVA-specific IgE production was found to be diminished in the administered mice. However, OVA-specific monoclonal IgG1 and IgG2a administration could not suppress food allergy. Because we detected OVA-IgG immune complex in the serum of mothers allergic to food, it might be a cause of maternal immune suppression. Conclusions We demonstrated that maternal specific IgG conjugated food antigen is an important factor related to the development of food allergy and acquiring tolerance.

      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.04.001
       
  • Cochineal dye-induced immediate allergy: Review of Japanese cases and
           proposed new diagnostic chart

    • Authors: Naoko Takeo; Masashi Nakamura; Satoshi Nakayama; Osamu Okamoto; Naoki Sugimoto; Shinichi Sugiura; Nayu Sato; Susumu Harada; Masao Yamaguchi; Naoya Mitsui; Yumiko Kubota; Kayoko Suzuki; Makoto Terada; Akiyo Nagai; Junko Sowa-Osako; Yutaka Hatano; Hiroshi Akiyama; Akiko Yagami; Sakuhei Fujiwara; Kayoko Matsunaga
      Abstract: Publication date: Available online 26 April 2018
      Source:Allergology International
      Author(s): Naoko Takeo, Masashi Nakamura, Satoshi Nakayama, Osamu Okamoto, Naoki Sugimoto, Shinichi Sugiura, Nayu Sato, Susumu Harada, Masao Yamaguchi, Naoya Mitsui, Yumiko Kubota, Kayoko Suzuki, Makoto Terada, Akiyo Nagai, Junko Sowa-Osako, Yutaka Hatano, Hiroshi Akiyama, Akiko Yagami, Sakuhei Fujiwara, Kayoko Matsunaga
      Background Cochineal dye is used worldwide as a red coloring in foods, drinks, cosmetics, quasi-drugs, and drugs. The main component of the red color is carminic acid (CA). Carmine is an aluminum- or calcium-chelated product of CA. CA and carmine usually contain contaminating proteins, including a 38-kDa protein thought to be the primary allergen. Severe allergic reactions manifest as anaphylaxis. The aim of this study was to review all Japanese reported cases and propose useful diagnostic chart. Methods All reported Japanese cases of cochineal dye-induced immediate allergy were reviewed, and newly registered cases were examined by skin prick test (SPT) with cochineal extract (CE) and measurement of CE and carmine-specific serum IgE test. Two-dimensional (2D) western blotting using patient serum was conducted to identify the antigen. Results Twenty-two Japanese cases have been reported. SPT and the level of specific IgE test indicated that six cases should be newly registered as cochineal dye allergy. All cases were adult females, and all cases except three involved anaphylaxis; 13 cases involved past history of local symptoms associated with cosmetics use. Japanese strawberry juice and fish-meat sausage, and European processed foods (especially macarons made in France) and drinks were recent major sources of allergen. 2D western blotting showed that patient IgE reacted to the 38-kDa protein and other proteins. Serum from healthy controls also weakly reacted with these proteins. Conclusions SPT with CE and determination of the level of CE and carmine-specific IgE test are useful methods for the diagnosis of cochineal dye allergy.

      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.02.012
       
  • The role of adenosine for IgE receptor-dependent degranulation of human
           peripheral basophils and skin mast cells

    • Authors: Yoshimi Matsuo; Yuhki Yanase; Reiko Irifuku; Kaori Ishii; Tomoko Kawaguchi; Shunsuke Takahagi; Izumi Hide; Michihiro Hide
      Abstract: Publication date: Available online 25 April 2018
      Source:Allergology International
      Author(s): Yoshimi Matsuo, Yuhki Yanase, Reiko Irifuku, Kaori Ishii, Tomoko Kawaguchi, Shunsuke Takahagi, Izumi Hide, Michihiro Hide


      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.03.007
       
  • Expression of Siglec-8 is regulated by interleukin-5, and serum levels of
           soluble Siglec-8 may predict responsiveness of severe eosinophilic asthma
           to mepolizumab

    • Authors: Sayaka Arakawa; Maho Suzukawa; Nobuharu Ohshima; Hiroyuki Tashimo; Isao Asari; Hirotoshi Matsui; Nobuyuki Kobayashi; Shunsuke Shoji; Takahide Nagase; Ken Ohta
      Abstract: Publication date: Available online 24 April 2018
      Source:Allergology International
      Author(s): Sayaka Arakawa, Maho Suzukawa, Nobuharu Ohshima, Hiroyuki Tashimo, Isao Asari, Hirotoshi Matsui, Nobuyuki Kobayashi, Shunsuke Shoji, Takahide Nagase, Ken Ohta


      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.03.006
       
  • Development of eosinophilic esophagitis following sublingual immunotherapy
           with cedar pollen extract: A case report

    • Authors: Kousaku Kawashima; Shunji Ishihara; Masaaki Masuhara; Hironobu Mikami; Eiko Okimoto; Naoki Oshima; Norihisa Ishimura; Asuka Araki; Riruke Maruyama; Yoshikazu Kinoshita
      Abstract: Publication date: Available online 24 April 2018
      Source:Allergology International
      Author(s): Kousaku Kawashima, Shunji Ishihara, Masaaki Masuhara, Hironobu Mikami, Eiko Okimoto, Naoki Oshima, Norihisa Ishimura, Asuka Araki, Riruke Maruyama, Yoshikazu Kinoshita


      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.03.003
       
  • Food-induced anaphylaxis in two patients who were using soap containing
           foodstuffs

    • Authors: Risa Tamagawa-Mineoka; Koji Masuda; Akiko Yagami; Masashi Nakamura; Nayu Sato; Kayoko Matsunaga; Norito Katoh
      Abstract: Publication date: Available online 16 April 2018
      Source:Allergology International
      Author(s): Risa Tamagawa-Mineoka, Koji Masuda, Akiko Yagami, Masashi Nakamura, Nayu Sato, Kayoko Matsunaga, Norito Katoh


      PubDate: 2018-06-01T02:50:12Z
      DOI: 10.1016/j.alit.2018.02.013
       
  • Severe asthma concomitant with allergic bronchopulmonary aspergillosis
           successfully treated with mepolizumab

    • Authors: Naohiro Oda; Nobuaki Miyahara; Satoru Senoo; Junko Itano; Akihiko Taniguchi; Daisuke Morichika; Utako Fujii; Yoshinobu Maeda; Katsuyuki Kiura; Arihiko Kanehiro
      Abstract: Publication date: Available online 14 April 2018
      Source:Allergology International
      Author(s): Naohiro Oda, Nobuaki Miyahara, Satoru Senoo, Junko Itano, Akihiko Taniguchi, Daisuke Morichika, Utako Fujii, Yoshinobu Maeda, Katsuyuki Kiura, Arihiko Kanehiro


      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.03.004
       
  • The relationship between complement levels and disease activity in
           Japanese family cases of hereditary angioedema with C1-INH deficiency

    • Authors: Atsushi Fukunaga; Shinji Tsuchiyama; Kasumi Lee; Ken Washio; Chinami Hashimura; Takahiko Horiuchi; Chikako Nishigori
      Abstract: Publication date: Available online 13 April 2018
      Source:Allergology International
      Author(s): Atsushi Fukunaga, Shinji Tsuchiyama, Kasumi Lee, Ken Washio, Chinami Hashimura, Takahiko Horiuchi, Chikako Nishigori


      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.03.002
       
  • Possible involvement of acetylcholine-mediated inflammation in airway
           diseases

    • Authors: Akira Koarai; Masakazu Ichinose
      Abstract: Publication date: Available online 28 March 2018
      Source:Allergology International
      Author(s): Akira Koarai, Masakazu Ichinose
      Inhaled bronchodilator treatment with a long acting muscarinic antagonist (LAMA) reduces symptoms and the risk of exacerbations in COPD and asthma. However, increasing evidence from cell culture and animal studies suggests that anti-muscarinic drugs could also possess anti-inflammatory effects. Recent studies have revealed that acetylcholine (ACh) can be synthesized and released from both neuronal and non-neuronal cells, and the released ACh can potentiate airway inflammation and remodeling in airway diseases. However, these anti-inflammatory effects of anti-muscarinic drugs have not yet been confirmed in COPD and asthma patients. This review will focus on recent findings about the possible involvement of ACh in airway inflammation and remodeling, and the anti-inflammatory effect of anti-muscarinic drugs in airway diseases. Clarifying the acetylcholine-mediated inflammation could provide insights into the mechanisms of airway diseases, which could lead to future therapeutic strategies for inhibiting the disease progression and exacerbations.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.02.008
       
  • TARC expression in the circulation and cutaneous granulomas correlates
           with disease severity and indicates Th2-mediated progression in patients
           with sarcoidosis

    • Authors: Chuyen Thi Hong Nguyen; Naotomo Kambe; Ikuko Ueda-Hayakawa; Izumi Kishimoto; Nhung Thi My Ly; Kana Mizuno; Hiroyuki Okamoto
      Abstract: Publication date: Available online 26 March 2018
      Source:Allergology International
      Author(s): Chuyen Thi Hong Nguyen, Naotomo Kambe, Ikuko Ueda-Hayakawa, Izumi Kishimoto, Nhung Thi My Ly, Kana Mizuno, Hiroyuki Okamoto
      Background Sarcoidosis is a systemic disorder characterized by the accumulation of lymphocytes and monocyte/macrophage lineage cells that results in the formation of non-caseating granulomas. Thymus- and activation-regulated chemokine (TARC)/CCL17 is an important chemokine in the amplification of Th2 responses, which are achieved by recruiting CCR4-expressing CD4+ T lymphocytes. TARC concentrations are known to increase in the serum of sarcoidosis patients; however, its role in the assessment of severity and prognosis of sarcoidosis remains unknown. The objective of this study is to elucidate the role of TARC in sarcoidosis by investigating its expression in peripheral blood and at inflammatory sites. We also examined its relationship with clinical features. Methods Serum levels of TARC, soluble interleukin 2 receptor, angiotensin-converting enzyme, and lysozyme were measured in 82 sarcoidosis patients. The Th1 and Th2 balance in circulating CD4+ T cells was evaluated by flow cytometry. The immunohistochemical staining of TARC and CCR4 was performed in order to identify the source of TARC in affected skin tissues. Results TARC serum levels were elevated in 78% of patients and correlated with disease severity. The percentage of CCR4+ cells and the CCR4+/CXCR3+ cell ratios were significantly higher in sarcoidosis patients than in normal subjects (P = 0.002 and P = 0.015, respectively). Moreover, TARC was expressed by monocyte/macrophage lineage cells within granulomas. The abundancy as well as distribution of TARC staining correlated with its serum levels. Conclusions The present results suggest that elevations in TARC drive an imbalanced Th2- weighted immune reaction and might facilitate prolonged inflammatory reactions in sarcoidosis.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.02.011
       
  • A rare case of drug-induced hypersensitivity syndrome by pirfenidone for
           idiopathic pulmonary fibrosis

    • Authors: Kumiko Suda; Koji Kamiya; Binluen Chiang; Hirofumi Okada; Naoko Mato; Takeo Maekawa; Mayumi Komine; Satoru Murata; Mamitaro Ohtsuki
      Abstract: Publication date: Available online 24 March 2018
      Source:Allergology International
      Author(s): Kumiko Suda, Koji Kamiya, Binluen Chiang, Hirofumi Okada, Naoko Mato, Takeo Maekawa, Mayumi Komine, Satoru Murata, Mamitaro Ohtsuki


      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.02.010
       
  • Association between impaired IL-10 production following exposure to
           Staphylococcus aureus enterotoxin B and disease severity in eosinophilic
           chronic rhinosinusitis

    • Authors: Takenori Haruna; Shin Kariya; Tazuko Fujiwara; Takaya Higaki; Seiichiro Makihara; Kengo Kanai; Rumi Fujiwara; Satoshi Iwasaki; Yoshihiro Noguchi; Kazunori Nishizaki; Mitsuhiro Okano
      Abstract: Publication date: Available online 23 March 2018
      Source:Allergology International
      Author(s): Takenori Haruna, Shin Kariya, Tazuko Fujiwara, Takaya Higaki, Seiichiro Makihara, Kengo Kanai, Rumi Fujiwara, Satoshi Iwasaki, Yoshihiro Noguchi, Kazunori Nishizaki, Mitsuhiro Okano
      Background IL-10 is a major anti-inflammatory cytokine that prevents inflammation-mediated tissue damage. We characterized the production of IL-10 by sinonasal tissue cells following exposure to Staphylococcus aureus enterotoxin B (SEB), which elicits cellular responses and is associated with the pathogenesis of eosinophilic chronic rhinosinusitis (ECRS). Methods Dispersed nasal polyp (NP) cells and uncinate tissue (UT) cells were prepared from patients with CRS with and without NP, respectively. Cells were incubated with SEB, and then the levels of IL-10 in the cell supernatants were determined. The effect of neutralizing IL-10 on SEB-induced IL-5, IL-13, IFN-γ, and IL-17A production was examined. Expression of IL-10 in NPs was also determined. Results IL-10 was expressed in infiltrating inflammatory cells in NPs. NP cells, especially non-adherent NP cells, produced substantial amounts of IL-10 in response to SEB. Although baseline production of IL-10 was significantly higher in NP cells than UT cells, the degree of IL-10 response to SEB was not significantly different between the cell types. The degree of IL-10 production was negatively correlated with the degree of eosinophilia both in tissues and peripheral blood whereas positively correlated with the 1-s forced expiratory volume/forced vital capacity ratio. Patients with severe ECRS displayed a significant decrease in IL-10 production compared with those with non-ECRS. IL-10 neutralization significantly augmented SEB-induced IL-13 and IFN-γ production by NP cells. Conclusions Impaired IL-10 production in response to SEB in NP may exacerbate the pathophysiology of ECRS including eosinophilia and lower airway obstruction.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.02.001
       
  • Nationwide questionnaire-based survey of oral immunotherapy in Japan

    • Authors: Sakura Sato; Chizuko Sugizaki; Noriyuki Yanagida; Komei Ito; Yusei Ohshima; Naoki Shimojo; Takao Fujisawa; Motohiro Ebisawa
      Abstract: Publication date: Available online 20 March 2018
      Source:Allergology International
      Author(s): Sakura Sato, Chizuko Sugizaki, Noriyuki Yanagida, Komei Ito, Yusei Ohshima, Naoki Shimojo, Takao Fujisawa, Motohiro Ebisawa
      Background Clinical trials on oral immunotherapy (OIT) have been increasing for nearly a decade; however, several national guidelines do not recommend OIT as a standardized procedure. The aim of this study was to obtain insights into the current use and practice of OIT in Japan. Methods A first questionnaire was mailed to 524 training and teaching facilities of the Japan Pediatric Society. The first survey requested information on the implementation of OIT, whereas the second survey aimed to gather more detailed information on OIT, such as its safety. Results In total, 360 facilities (69%) responded to the survey; among them, 102 (28%) provided OIT to 7973 patients [1544 received OIT while hospitalized (inpatient OIT), whereas 6429 received OIT without hospitalization (outpatient OIT)]. Approval for OIT was obtained from an ethics committee or institutional review board in 89% and 31% of facilities for inpatient and outpatient OIT, respectively. In inpatient OIT, immediate allergic reactions requiring treatment occurred in 68% of patients while hospitalized, and in another 56%, following discharge. In contrast, 11% of patients developed immediate allergic reactions in outpatient OIT. Adrenaline injections at home were required in 2%. Sixteen patients developed adverse reactions other than immediate allergic reactions, among which eosinophilic gastroenteritis was most common. Conclusions OIT is widely provided not only as clinical research but also as general practice in Japan. However, because there is a high risk of developing anaphylaxis at home, OIT should be conducted carefully as in a clinical research setting taking safety into consideration.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.02.006
       
  • Epidemiology of asthma-chronic obstructive pulmonary disease overlap (ACO)

    • Authors: Akifumi Uchida; Kohta Sakaue; Hiromasa Inoue
      Abstract: Publication date: Available online 15 March 2018
      Source:Allergology International
      Author(s): Akifumi Uchida, Kohta Sakaue, Hiromasa Inoue
      The term “asthma-COPD overlap” (ACO) has been applied to the condition in which a person has persistent airflow limitation with clinical features of both asthma and COPD. The certain definition and diagnostic criteria for ACO have not yet been established, and ACO prevalence has varied widely in studies: from 0.9% to 11.1% in the general population, from 11.1% to 61.0% in asthma patients, and from 4.2% to 66.0% in COPD patients. Furthermore, the frequency of exacerbations and prognosis in ACO patients have not been clearly demonstrated. Although ACO consists with several subgroups of patients with distinct clinical and pathophysiological features, it would be important to propose a standardized definition of and/or diagnostic criteria for ACO based on biomarkers and objective measures, even if it is tentative. It may lead cohort studies with large population or clinical trials around the world.

      PubDate: 2018-03-17T12:53:41Z
      DOI: 10.1016/j.alit.2018.02.002
       
  • Asthma and COPD overlap pathophysiology of ACO

    • Authors: Mari Hikichi; Shu Hashimoto; Yasuhiro Gon
      Abstract: Publication date: Available online 15 March 2018
      Source:Allergology International
      Author(s): Mari Hikichi, Shu Hashimoto, Yasuhiro Gon
      Asthma and COPD appear as a result of different mechanisms triggered by different pathogeneses and although they present different features and symptoms of airway inflammation and airway obstruction, there are also cases that present the features of both asthma and COPD. This type of pathology is known as asthma-COPD overlap syndrome (ACOS). Asthma-COPD overlap is identified in clinical practice by the features that it shares with both asthma and COPD. This is not a definition, but a description for clinical use, as asthma-COPD overlap includes several different clinical phenotypes and there are likely to be several different underlying mechanisms”. In this paper, the disease that shares several features of both asthma and COPD will be referred to as asthma-COPD overlap (ACO). In this article, we describe the pathogenesis of ACO for understanding the mechanism in asthma and COPD overlap.

      PubDate: 2018-03-17T12:53:41Z
      DOI: 10.1016/j.alit.2018.01.001
       
  • Definition and diagnosis of asthma–COPD overlap (ACO)

    • Authors: Satoru Yanagisawa; Masakazu Ichinose
      Abstract: Publication date: Available online 9 February 2018
      Source:Allergology International
      Author(s): Satoru Yanagisawa, Masakazu Ichinose
      It is now widely recognized that asthma and COPD can coexist as asthma–COPD overlap (ACO), but the preliminary attempts at providing universal guidelines for the diagnosis of ACO still need to be improved. We believe that a case can be made for devising guidelines for the diagnosis of this increasingly common disease that are specific to Japan. In this paper, we present our consensus-based description of ACO which we believe is realistic for use in our country. In addition, we cite the scientific evidence for our own “objective” features used to develop the criteria for COPD and asthma diagnosis. We acknowledge that they will need to be validated and updated over time, but hope the results will encourage further research on the characteristics and treatment of this commonly encountered clinical problem.

      PubDate: 2018-02-13T10:09:03Z
      DOI: 10.1016/j.alit.2018.01.002
       
  • Aquagenic urticaria: Severe extra-cutaneous symptoms following cold water
           exposure

    • Authors: Takeshi Fukumoto; Kanako Ogura; Atsushi Fukunaga; Chikako Nishigori
      Abstract: Publication date: Available online 9 January 2018
      Source:Allergology International
      Author(s): Takeshi Fukumoto, Kanako Ogura, Atsushi Fukunaga, Chikako Nishigori


      PubDate: 2018-01-10T10:38:05Z
      DOI: 10.1016/j.alit.2017.10.007
       
 
 
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