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Showing 1 - 200 of 3175 Journals sorted alphabetically
A Practical Logic of Cognitive Systems     Full-text available via subscription   (Followers: 8)
AASRI Procedia     Open Access   (Followers: 14)
Academic Pediatrics     Hybrid Journal   (Followers: 28, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 22, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 90, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 25, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 33, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 5)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 6, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 376, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 2)
Acta Biomaterialia     Hybrid Journal   (Followers: 27, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 2)
Acta de Investigación Psicológica     Open Access   (Followers: 3)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (Followers: 1, SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 235, SJR: 3.683, h-index: 202)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.615, h-index: 21)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 10, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription  
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 2, SJR: 0.311, h-index: 16)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 25, SJR: 1.365, h-index: 73)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.383, h-index: 19)
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Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 5, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 3, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 6)
Acute Pain     Full-text available via subscription   (Followers: 14)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 7)
Additive Manufacturing     Hybrid Journal   (Followers: 9, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 22)
Advanced Cement Based Materials     Full-text available via subscription   (Followers: 3)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 128, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 16, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 8, SJR: 0.299, h-index: 15)
Advances in Agronomy     Full-text available via subscription   (Followers: 12, SJR: 2.071, h-index: 82)
Advances in Anesthesia     Full-text available via subscription   (Followers: 27, SJR: 0.169, h-index: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 2)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 10, SJR: 1.054, h-index: 35)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 10, SJR: 0.801, h-index: 26)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 22, SJR: 1.286, h-index: 49)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 14, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
Advances in Botanical Research     Full-text available via subscription   (Followers: 2, SJR: 0.619, h-index: 48)
Advances in Cancer Research     Full-text available via subscription   (Followers: 28, SJR: 2.215, h-index: 78)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 7, SJR: 0.9, h-index: 30)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 2.139, h-index: 42)
Advances in Cell Aging and Gerontology     Full-text available via subscription   (Followers: 3)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 27, SJR: 0.183, h-index: 23)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 10, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 19, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 14, SJR: 0.223, h-index: 22)
Advances in Dermatology     Full-text available via subscription   (Followers: 14)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 10)
Advances in Digestive Medicine     Open Access   (Followers: 8)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 21)
Advances in Ecological Research     Full-text available via subscription   (Followers: 42, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 27, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 6)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 42, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 1)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 7)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 54, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 15)
Advances in Genetics     Full-text available via subscription   (Followers: 14, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 7)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 21, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 0.497, h-index: 31)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 23)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 1, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 36, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 2, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 3)
Advances in Life Course Research     Hybrid Journal   (Followers: 8, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Marine Biology     Full-text available via subscription   (Followers: 14, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 21)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 8)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 3)
Advances in Oncobiology     Full-text available via subscription   (Followers: 1)
Advances in Organ Biology     Full-text available via subscription   (Followers: 1)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 6, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 5, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 24, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 10)
Advances in Pharmacology     Full-text available via subscription   (Followers: 15, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 7)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 17)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 18, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 59)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 6, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.1, h-index: 2)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 5)
Advances in Space Research     Full-text available via subscription   (Followers: 375, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 5)
Advances in Surgery     Full-text available via subscription   (Followers: 9, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 29, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 17)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 46, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 6, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 333, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 6, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 9, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 429, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 31, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 43, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access   (Followers: 1)
Agriculture and Natural Resources     Open Access   (Followers: 2)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 56, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 5, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 11, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 9)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access   (Followers: 1)
Algal Research     Partially Free   (Followers: 9, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 5, SJR: 0.776, h-index: 35)
Alpha Omegan     Full-text available via subscription   (SJR: 0.121, h-index: 9)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 9, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 48, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 4)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 4)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 6)
American Heart J.     Hybrid Journal   (Followers: 50, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 50, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 42, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 10, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 31, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 26, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 32, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 42, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 189, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 62, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 6)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 25, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 27, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 27, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 37, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 6)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 61, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 14)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 4, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 39, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 165, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 10, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 11)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 1)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 22, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1)

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Journal Cover Allergology International
  [SJR: 0.776]   [H-I: 35]   [5 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 1323-8930 - ISSN (Online) 1440-1592
   Published by Elsevier Homepage  [3175 journals]
  • Asthma-chronic obstructive pulmonary disease overlap (ACO): An emerging
           entity in allergic respiratory diseases

    • Authors: Jun Tamaoki; Kenji Izuhara
      Pages: 163 - 164
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Jun Tamaoki, Kenji Izuhara

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.03.001
  • Therapeutic approaches of asthma and COPD overlap

    • Authors: Mitsuko Kondo; Jun Tamaoki
      Pages: 187 - 190
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Mitsuko Kondo, Jun Tamaoki
      Asthma and COPD overlap (ACO) is an important clinical phenotype, due to the low-health-related quality of life (QOL), rapid decline in lung function, frequent exacerbation, and high economic burden. However, no large-scaled therapeutic trials of ACO have been conducted. At present, ACO is treated according to asthma/COPD guidelines. The goals of ACO treatment are to relieve symptoms and improve QOL and lung functions. Treatment must also prevent disease progression, airway remodeling, exacerbation, complications, and comorbidities. To achieve these goals, ACO needs first to be assessed based on pathophysiological findings. Comprehensive long-term management includes medication, reduction of risk factors, environmental improvement, patient education, rehabilitation, and vaccination. Drug treatment for ACO employs a combination of inhaled corticosteroids (ICSs) and long-acting bronchodilators; long-acting muscarinic antagonists and/or long-acting β2-agonists. The dose of ICS is determined according to ACO severity. Leukotriene receptor antagonists and theophylline are used as add-on drugs. Macrolides and expectorants are recommended for reduction of mucus hypersecretion. Anti-IgE and anti–IL-5 antibodies, oral corticosteroids, and oxygen therapy are additional treatments for the most severe ACO. The therapeutic effects are evaluated using lung function tests, eosinophil counts in sputum and blood, FeNO, and symptom questionnaires. ACO exacerbation is treated by inhalation of short-acting β2-agonist and systemic corticosteroids. The doses of corticosteroids are determined based on the asthma/COPD component of the exacerbation. Administration of antibiotics is recommended if sputum is purulent. Referral to specialists is necessary in cases of inability to control symptoms by medication, uncertain diagnosis with atypical features, or severe complications and comorbidities.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.09.002
  • Chronic spontaneous urticaria and the extrinsic coagulation system

    • Authors: Yuhki Yanase; Shunsuke Takahagi; Michihiro Hide
      Pages: 191 - 194
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Yuhki Yanase, Shunsuke Takahagi, Michihiro Hide
      Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch. Recently, the activation of the blood coagulation cascade has been suggested to be involved in CSU, but the trigger of the coagulation cascade remains unclear. In this article, we review recent understanding of the relationship between the pathogenesis of CSU and extrinsic coagulation reactions. In CSU, vascular endothelial cells and eosinophils may play a role as TF-expressing cells for activating the extrinsic coagulation pathway. Moreover, the expression of TF on endothelial cells is synergistically enhanced by the activation of Toll-like receptors and histamine H1 receptors. The activated coagulation factors may induce plasma extravasation followed by degranulation of skin mast cells and edema formation recognized as wheal in CSU. Molecules involved in this cascade could be a target for new and more effective treatments of urticaria.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.09.003
  • An analysis of factors related to the effect of sublingual immunotherapy
           on Japanese cedar pollen induced allergic rhinitis

    • Authors: Syuji Yonekura; Yoshitaka Okamoto; Daiju Sakurai; Kimihiro Okubo; Minoru Gotoh; Shinya Kaneko; Akiyoshi Konno
      Pages: 201 - 208
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Syuji Yonekura, Yoshitaka Okamoto, Daiju Sakurai, Kimihiro Okubo, Minoru Gotoh, Shinya Kaneko, Akiyoshi Konno
      Background Sublingual immunotherapy (SLIT) can improve the symptoms of allergic rhinitis and modify its natural history; however, its efficacy varies among patients. This study aimed to determine which factors modify the effect of SLIT through post hoc analysis of a previous phase 3 trial of standardized Japanese cedar (JC) pollen extract (CEDARTOLEN®). Methods The study included 482 patients who had previously completed a phase 3 trial during two seasons. The SLIT and placebo groups each contained 241 subjects. Because pollen dispersal differed in the two seasons, we identified good and poor responders from the SLIT group in the 2nd season. We compared patient baseline characteristics, changes in serum immunoglobulin, and severity of symptoms in the 1st season between good and poor responders, as well as between SLIT and placebo groups. Results When we compared the baseline characteristics of good and poor responders, a significant difference was observed in body mass index (BMI) such that the patients with BMI ≥25 presented with lower treatment efficacy. No significant difference was observed in correlation with any other factors or treatment-induced alterations of serum immunoglobulin levels. We found that 75.3% of the patients with moderate symptoms and 50.9% of the patients with severe or very severe symptoms in the 1st season met our criteria for good responders in the 2nd season. Conclusions BMI might modify the effect of SLIT; however, other factors were not related clearly. The severity of symptoms in the 1st season of treatment does not predict that in the 2nd season.
      Graphical abstract image

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.07.005
  • Desensitization to a whole egg by rush oral immunotherapy improves the
           quality of life of guardians: A multicenter, randomized, parallel-group,
           delayed-start design study

    • Authors: Naoka Itoh-Nagato; Yuzaburo Inoue; Mizuho Nagao; Takao Fujisawa; Naoki Shimojo; Tsutomu Iwata; Yuichi Adachi; Koichi Arakawa; Takayasu Arima; Keitaro Fukushima; Akira Hoshioka; Takashi Igarashi; Toshiko Itazawa; Komei Itoh; Makoto Kameda; Naoyuki Kando; Izumi Kato; Taeru Kitabayashi; Takae Kobayashi; Harumi Koyama; Yoshinori Morita; Taiji Nakano; Shuichi Suzuki; Yuri Takaoka; Minako Tomiita; Hisako Yagi; Yuko Yajima; Akiko Yamaide; Masahiro Yasui; Shigemi Yoshihara
      Pages: 209 - 216
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Naoka Itoh-Nagato, Yuzaburo Inoue, Mizuho Nagao, Takao Fujisawa, Naoki Shimojo, Tsutomu Iwata
      Background Patients with food allergies and their families have a significantly reduced health-related quality of life (QOL). Methods We performed a multicenter, randomized, parallel-group, delayed-start design study to clarify the efficacy and safety of rush oral immunotherapy (rOIT) and its impact on the participants' daily life and their guardians (UMIN000003943). Forty-five participants were randomly divided into an early-start group and a late-start group. The early-start group received rOIT for 3 months, while the late-start group continued the egg elimination diet (control). In the next stage, both groups received OIT until all participants had finished 12 months of maintenance OIT. Results The ratio of the participants in whom an increase of the TD was achieved in the first stage was significantly higher in the early-start group (87.0%), than in the late-start group (22.7%). The QOL of the guardians in the early-start group significantly improved after the first stage (65.2%), in comparison to the late-start group (31.8%). During 12 months of rOIT, the serum ovomucoid-specific IgE levels, the percentage of CD203c+ basophils upon stimulation with egg white, and the wheal size to egg white were decreased, while the serum ovomucoid-specific IgG4 levels were increased. However, approximately 80% of the participants in the early-start group showed an allergic reaction during the first stage of the study, whereas none of the patients in the late-start group experienced an allergic reaction. Conclusions rOIT induced desensitization to egg and thus improved the QOL of guardians; however, the participants experienced frequent allergic reactions due to the treatment.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.07.007
  • Hand eczema as a risk factor for food allergy among occupational kitchen

    • Authors: Takafumi Minami; Yuma Fukutomi; Kiyoshi Sekiya; Akira Akasawa; Masami Taniguchi
      Pages: 217 - 224
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Takafumi Minami, Yuma Fukutomi, Kiyoshi Sekiya, Akira Akasawa, Masami Taniguchi
      Background An increasing number of studies in children is highlighting the importance of transdermal routes of exposure to food allergens through damaged skin in the pathogenesis of food allergies. However, data on this in adults are limited. A few case-series studies has documented development of food allergy among kitchen workers with hand eczema after direct contact exposure to foods. Methods To explore the significance of hand eczema as a risk factor for food allergies in adults at the epidemiological level, we performed a cross-sectional web-based questionnaire survey on kitchen workers whose exposures were classed as occupational (cooks and food handlers, n = 1592) or non-occupational (housewives, n = 1915). Logistic regression was used to explore the association between the presence/severity of hand eczema and the risk of food allergy after adjustment for potential confounders. Results Current hand eczema and current diagnosed food allergy were more common among occupational kitchen workers (OKW) than among non-occupational kitchen workers (NOKW) (32.3%-vs-29.9% and 9.9%-vs-3.8%, respectively). Current hand eczema was significantly associated with increased risk of current diagnosed food allergy in OKW (adjusted odds ratio 2.4, 95% CI 1.6–3.7). Those with more severe hand eczema were more likely to suffer from allergic symptoms for foods, and diagnosed food allergy. Conclusions This study illustrates a significant public health problem in the adult population, documenting a major impact of hand eczema on the ongoing adult food allergy epidemic.
      Graphical abstract image

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.08.005
  • Exposure amount and timing of solar irradiation during pregnancy and the
           risk of sensitization in children

    • Authors: Hyun Yong Koh; Eunhae Cho; So-Yeon Lee; Woo Kyung Kim; Yong Mean Park; Jihyun Kim; Kangmo Ahn; Seung Won Lee; Mi Ae Kim; Myung-Il Hahm; Yoomi Chae; Kee-Jae Lee; Ho-Jang Kwon; Man Yong Han
      Pages: 225 - 233
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Hyun Yong Koh, Eunhae Cho, So-Yeon Lee, Woo Kyung Kim, Yong Mean Park, Jihyun Kim, Kangmo Ahn, Seung Won Lee, Mi Ae Kim, Myung-Il Hahm, Yoomi Chae, Kee-Jae Lee, Ho-Jang Kwon, Man Yong Han
      Background Solar irradiation affects sensitization to aeroallergens and the prevalence of allergic diseases. Little is known, however, about how the time and amount of solar irradiation during pregnancy affects such risks in children. We aimed to find out how solar irradiation during pregnancy affects sensitization to aero-allergens and the prevalence of allergic diseases in children. Methods This population-based cross-sectional study involved 7301 aged 6 years and aged 12 years children. Maternal exposure to solar irradiation during pregnancy was evaluated using data from weather stations closest to each child's birthplace. Monthly average solar irradiation during the second and third trimesters was calculated with rank by quartiles. Risks of allergic sensitization and allergic disease were estimated. Results Relative to the first (lowest) quartile, the adjusted odds ratio (aOR) for allergic sensitization in the fourth (highest) quartile was lowest within solar irradiation during pregnancy months 5–6 (aOR = 0.823, 95% CI 0.720–0.942, p < 0.05). During months 9–10, the aOR for allergic sensitization for the fourth was higher than the first quartile of solar irradiation (aOR = 1.167, 95% CI 1.022–1.333, p < 0.05). Similar results were observed when solar irradiation was analyzed as a continuous variable during months 5 (aOR = 0.975, 95% CI 0.962–0.989, p < 0.001) and month 9 (aOR = 1.018, 95% CI 1.004–1.031, p = 0.003). Increased solar irradiation during months 7–8 increased the risk of asthma (aOR = 1.309, 95% CI 1.024–1.674, p = 0.032). Conclusions Maternal exposure to solar irradiation during the second trimester of pregnancy associated with reduced aeroallergen sensitization, whereas solar irradiation during the third trimester was related to increased sensitization to aeroallergens.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.08.007
  • Mast cells derived from human induced pluripotent stem cells are useful
           for allergen tests

    • Authors: Akira Igarashi; Yasuhiro Ebihara; Tomoaki Kumagai; Hiroyuki Hirai; Kinya Nagata; Kohichiro Tsuji
      Pages: 234 - 242
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Akira Igarashi, Yasuhiro Ebihara, Tomoaki Kumagai, Hiroyuki Hirai, Kinya Nagata, Kohichiro Tsuji
      Background Several methods have been developed to detect allergen-specific IgE in sera. The passive IgE sensitization assay using human IgE receptor-expressing rat cell line RBL-2H3 is a powerful tool to detect biologically active allergen-specific IgE in serum samples. However, one disadvantage is that RBL-2H3 cells are vulnerable to high concentrations of human sera. Only a few human cultured cell lines are easily applicable to the passive IgE sensitization assay. However, the use of human induced pluripotent stem cells (iPSCs) to generate human mast cells (MCs) has not yet been reported. Methods The nuclear factor-kappa B (NF-κB)-responsive luciferase reporter gene was stably introduced into a human iPSC line 201B7, and the transfectants were induced to differentiate into MCs (iPSC-MCs). The iPSC-MCs were sensitized overnight with sera from subjects who were allergic to cedar pollen, ragweed pollen, mites, or house dust, and then stimulated with an extract of corresponding allergens. Activation of iPSC-MCs was evaluated by β-hexosaminidase release, histamine release, or luciferase intensity. Results iPSCs-MCs stably expressed high-affinity IgE receptor and functionally responded to various allergens when sensitized with human sera from relevant allergic subjects. This passive IgE sensitization system, which we termed the induced mast cell activation test (iMAT), worked well even with undiluted human sera. Conclusions iMAT may serve as a novel determining system for IgE/allergens in the clinical and research settings.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.08.008
  • Efficacy and safety of omalizumab for the treatment of refractory chronic
           spontaneous urticaria in Japanese patients: Subgroup analysis of the phase
           3 POLARIS study

    • Authors: Michihiro Hide; Atsuyuki Igarashi; Akiko Yagami; Yuko Chinuki; Naoko Inomata; Atsushi Fukunaga; Guenther Kaiser; Junyi Wang; Soichiro Matsushima; Steven Greenberg; Sam Khalil
      Pages: 243 - 252
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Michihiro Hide, Atsuyuki Igarashi, Akiko Yagami, Yuko Chinuki, Naoko Inomata, Atsushi Fukunaga, Guenther Kaiser, Junyi Wang, Soichiro Matsushima, Steven Greenberg, Sam Khalil
      Background Omalizumab, a humanized anti-IgE monoclonal antibody, proved efficacious and well tolerated in patients with chronic spontaneous urticaria (CSU) refractory to H1 antihistamines (H1AH) in the POLARIS study (NCT02329223), a randomized, double-blind, placebo-controlled trial in East Asian patients. However, data in Japanese patients, who have specific baseline characteristics (e.g., low angioedema incidence, different background medications) that may impact clinical outcomes, are lacking. This pre-specified analysis presents additional patient-level data over time, pharmacokinetic and pharmacodynamics data for omalizumab and IgE, and efficacy and safety data for omalizumab in Japanese patients. Methods Japanese patients (N = 105) were randomized 1:1:1 to omalizumab 300 mg, 150 mg, or placebo by subcutaneous injection every 4 weeks. Efficacy and safety were assessed primarily based on changes from baseline to Week 12 in weekly itch-severity scores (ISS7) and weekly urticaria activity scores (UAS7), and incidence of adverse events (AEs), respectively. Patient-level UAS7 data over time were also reviewed. Results At Week 12, least squares mean (LSM) changes from baseline in ISS7 were greater with omalizumab vs. placebo (−9.54 and −7.29 for omalizumab 300 mg and 150 mg, respectively, vs. placebo [−5.17]). Corresponding LSM changes from baseline in UAS7 were −21.61 and −15.59 (vs. placebo [−10.88]). Most responders in the omalizumab 300 mg group displayed improvement of disease activity within 2–4 weeks and had well-controlled symptoms during the treatment period. Overall AE incidence was similar across treatment arms. Conclusions This subgroup analysis demonstrated that omalizumab is a well-tolerated, beneficial option for treatment of CSU in H1AH-refractory Japanese patients.
      Graphical abstract image

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.10.001
  • Phenotype classification using the combination of lung sound analysis and
           fractional exhaled nitric oxide for evaluating asthma treatment

    • Authors: Terufumi Shimoda; Yasushi Obase; Yukio Nagasaka; Sadahiro Asai
      Pages: 253 - 258
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Terufumi Shimoda, Yasushi Obase, Yukio Nagasaka, Sadahiro Asai
      Background We report the utility of combining lung sound analysis and fractional exhaled nitric oxide (FeNO) for phenotype classification of airway inflammation in patients with bronchial asthma. We investigated the usefulness of the combination of the expiration-to-inspiration sound power ratio in the mid-frequency range (E/I MF) of 200–400 Hz and FeNO for comprehensively classifying disease type and evaluating asthma treatment. Methods A total of 233 patients with bronchial asthma were included. The cutoff values of FeNO and E/I MF were set to 38 ppb and 0.36, respectively, according to a previous study. The patients were divided into 4 subgroups based on the FeNO and E/I MF cutoff values. Respiratory function, the percentages of sputum eosinophils and neutrophils, and patient background characteristics were compared among groups. Results Respiratory function was well controlled in the FeNO low/E/I MF low group (good control). Sputum neutrophil was higher and FEV1,%pred was lower in the FeNO low/E/I MF high group (poor control). History of childhood asthma and atopic asthma were associated with the FeNO high/E/I MF low group (insufficient control). The FeNO high/E/I MF high group corresponded to a longer disease duration, increased blood or sputum eosinophils, and lower FEV1/FVC (poor control). Conclusions The combination of FeNO and E/I MF assessed by lung sound analysis allows the condition of airway narrowing and the degree of airway inflammation to be assessed in patients with asthma and is useful for evaluating bronchial asthma treatments.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.09.004
  • Up-regulation of serum periostin and squamous cell carcinoma antigen
           levels in infants with acute bronchitis due to respiratory syncytial virus

    • Authors: Hiroaki Nakamura; Kenichi Akashi; Masako Watanabe; Shoichiro Ohta; Junya Ono; Yoshinori Azuma; Noriko Ogasawara; Keisuke Yamamoto; Norikazu Shimizu; Hiroyuki Tsutsumi; Kenji Izuhara; Toshio Katsunuma
      Pages: 259 - 265
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Hiroaki Nakamura, Kenichi Akashi, Masako Watanabe, Shoichiro Ohta, Junya Ono, Yoshinori Azuma, Noriko Ogasawara, Keisuke Yamamoto, Norikazu Shimizu, Hiroyuki Tsutsumi, Kenji Izuhara, Toshio Katsunuma
      Background Periostin and squamous cell carcinoma antigen (SCCA) are involved in the pathogenesis of asthma. Acute bronchitis due to respiratory syncytial virus (RSV) infection during infancy exhibits an asthma-like pathogenesis, suggesting that it may be associated with the subsequent development of asthma. However, the mechanism by which RSV infection leads to development of asthma has not yet been fully elucidated. Methods Infants younger than 36 months were enrolled and classified into three groups. Group I included patients hospitalized with RSV-induced bronchitis. These patients were further stratified into two sub-groups according to whether the criteria for the modified Asthma Predictive Index (mAPI) had been met: Group I consisted of mAPI (+) and mAPI (−) patients; Group II included patients with food allergy as a positive control group; and Group III included children with no allergy as a negative control group. Serum periostin and SCCA levels were measured in the groups. This study was registered as a clinical trial (UMIN000012339). Results We enrolled 14 subjects in Group I mAPI (+), 22 in Group I mAPI (−), 18 in Group II, and 18 in Group III. In Group I, the serum periostin and SCCA levels were significantly higher during the acute phase compared with the recovery phase. However, no significant differences were found between Group I mAPI (+) and mAPI (−). Conclusions The serum periostin and SCCA levels increased during acute RSV bronchitis. Both periostin and SCCA may play a role in the pathogenesis of acute bronchitis due to RSV.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.10.003
  • Efficacy and safety of benralizumab in Japanese patients with severe,
           uncontrolled eosinophilic asthma

    • Authors: Ken Ohta; Mitsuru Adachi; Yuji Tohda; Tadashi Kamei; Motokazu Kato; J. Mark Fitzgerald; Masayuki Takanuma; Tadahiro Kakuno; Nobuyuki Imai; Yanping Wu; Magnus Aurivillius; Mitchell Goldman
      Pages: 266 - 272
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Ken Ohta, Mitsuru Adachi, Yuji Tohda, Tadashi Kamei, Motokazu Kato, J. Mark Fitzgerald, Masayuki Takanuma, Tadahiro Kakuno, Nobuyuki Imai, Yanping Wu, Magnus Aurivillius, Mitchell Goldman
      Background In the Phase III CALIMA trial, benralizumab significantly reduced asthma exacerbations, increased lung function, and alleviated symptoms for patients with severe, uncontrolled eosinophilic asthma. The aim of this subgroup analysis was to evaluate the efficacy and safety of benralizumab for Japanese patients in the CALIMA trial. Methods CALIMA was a randomised, controlled trial of 1306 patients (aged 12–75 years; registered at NCT01914757) with severe asthma uncontrolled by medium- to high-dosage inhaled corticosteroids and long-acting β2-agonists (ICS/LABA). Patients received 56 weeks' benralizumab 30 mg either every 4 weeks (Q4W) or every 8 weeks (Q8W; first three doses Q4W), or placebo Q4W. The primary analysis population was patients receiving high-dosage ICS/LABA with blood eosinophils ≥300 cells/μL. This subgroup analysis covered Japanese patients from this group. Results Of 83 patients randomised in Japan, 46 were receiving high-dosage ICS/LABA and had blood eosinophils ≥300 cells/μL. Compared with placebo, benralizumab reduced the annual rate of asthma exacerbations by 66% (Q4W; rate ratio 0.34, 95% CI, 0.11–0.99) and 83% (Q8W; rate ratio 0.17, 95% CI, 0.05–0.60); increased prebronchodilator FEV1 by 0.334 L (Q4W; 95% CI, 0.020–0.647) and 0.198 L (Q8W; 95% CI, −0.118 to 0.514); and decreased total asthma symptom score by 0.17 (Q4W; 95% CI, −0.82 to 0.48) and 0.24 (Q8W; 95% CI, −0.87 to 0.40). Percentages of adverse events were consistent with the overall CALIMA group. Conclusions Benralizumab reduced annual asthma exacerbations and symptoms, increased lung function, and was well-tolerated by Japanese patients with severe, uncontrolled eosinophilic asthma.
      Graphical abstract image

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.10.004
  • Bronchial thermoplasty for severe uncontrolled asthma in Japan

    • Authors: Motoyasu Iikura; Masayuki Hojo; Naoko Nagano; Keita Sakamoto; Konomi Kobayashi; Shota Yamamoto; Masao Hashimoto; Satoru Ishii; Shinyu Izumi; Haruhito Sugiyama
      Pages: 273 - 275
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Motoyasu Iikura, Masayuki Hojo, Naoko Nagano, Keita Sakamoto, Konomi Kobayashi, Shota Yamamoto, Masao Hashimoto, Satoru Ishii, Shinyu Izumi, Haruhito Sugiyama

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.07.006
  • Urticaria by thiamine (vitamin B1)

    • Authors: Ana Rodríguez-Fernández; Marcos Sánchez-Domínguez; Blanca Noguerado-Mellado; Patricia Rojas-Pérez-Ezquerra
      Pages: 276 - 277
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Ana Rodríguez-Fernández, Marcos Sánchez-Domínguez, Blanca Noguerado-Mellado, Patricia Rojas-Pérez-Ezquerra

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.07.008
  • Omalizumab for hypersensitive reaction to seminal plasma: A case report

    • Authors: Maria Teresa Burguete-Cabanas; Oscar R. Fajardo-Ramirez; Roberta Yesaki; Raul Estrada-Maganas; Sandra Salazar-Meza; Olga Rios-Chavez; Irene Meester; Julio C. Salas-Alanis
      Pages: 278 - 279
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Maria Teresa Burguete-Cabanas, Oscar R. Fajardo-Ramirez, Roberta Yesaki, Raul Estrada-Maganas, Sandra Salazar-Meza, Olga Rios-Chavez, Irene Meester, Julio C. Salas-Alanis

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.07.009
  • Mucus plugging in allergic bronchopulmonary aspergillosis: Implication of
           the eosinophil DNA traps

    • Authors: Ayumi Omokawa; Shigeharu Ueki; Yuta Kikuchi; Masahide Takeda; Mariko Asano; Kazuhiro Sato; Masaaki Sano; Hiroshi Ito; Makoto Hirokawa
      Pages: 280 - 282
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Ayumi Omokawa, Shigeharu Ueki, Yuta Kikuchi, Masahide Takeda, Mariko Asano, Kazuhiro Sato, Masaaki Sano, Hiroshi Ito, Makoto Hirokawa

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.08.002
  • Long-term course of serum total and free IgE levels in severe asthma
           patients treated with omalizumab

    • Authors: Yasuhiro Gon; Reiko Ito; Shuichiro Maruoka; Kenji Mizumura; Yutaka Kozu; Hisato Hiranuma; Yuko Iida; Mari Hikichi; Sotaro Shikano; Shu Hashimoto
      Pages: 283 - 285
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Yasuhiro Gon, Reiko Ito, Shuichiro Maruoka, Kenji Mizumura, Yutaka Kozu, Hisato Hiranuma, Yuko Iida, Mari Hikichi, Sotaro Shikano, Shu Hashimoto

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.08.003
  • A case of clinically amyopathic dermatomyositis that developed during
           anti-TNF-α therapy for rheumatoid arthritis

    • Authors: Miki Takata; Akira Yamasaki; Nanako Yamada; Hiroshi Hagino; Yoshihiro Funaki; Tomoya Harada; Ryota Okazaki; Yasuyuki Hasegawa; Takehito Fukushima; Masato Morita; Yuriko Sueda; Akihiro Yamamoto; Eiji Shimizu
      Pages: 286 - 288
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Miki Takata, Akira Yamasaki, Nanako Yamada, Hiroshi Hagino, Yoshihiro Funaki, Tomoya Harada, Ryota Okazaki, Yasuyuki Hasegawa, Takehito Fukushima, Masato Morita, Yuriko Sueda, Akihiro Yamamoto, Eiji Shimizu

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.09.001
  • Vitamin D deficiency exacerbates sensitization and allergic diarrhea in a
           murine food allergy model

    • Authors: Teruaki Matsui; Hirotaka Yamashita; Ken-ichi Saneyasu; Hiroyuki Tanaka; Komei Ito; Naoki Inagaki
      Pages: 289 - 291
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Teruaki Matsui, Hirotaka Yamashita, Ken-ichi Saneyasu, Hiroyuki Tanaka, Komei Ito, Naoki Inagaki

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.08.010
  • How important is allergic sensitization as a cause of atopic asthma'

    • Authors: Jun Kanazawa; Hironori Masuko; Hideyasu Yamada; Yohei Yatagai; Tohru Sakamoto; Haruna Kitazawa; Hiroaki Iijima; Takashi Naito; Tomomitsu Hirota; Mayumi Tamari; Nobuyuki Hizawa
      Pages: 292 - 294
      Abstract: Publication date: April 2018
      Source:Allergology International, Volume 67, Issue 2
      Author(s): Jun Kanazawa, Hironori Masuko, Hideyasu Yamada, Yohei Yatagai, Tohru Sakamoto, Haruna Kitazawa, Hiroaki Iijima, Takashi Naito, Tomomitsu Hirota, Mayumi Tamari, Nobuyuki Hizawa

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2017.10.005
  • Barrier dysfunction in allergy

    • Authors: Kenji Kabashima; Kenji Izuhara
      Pages: 1 - 2
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Kenji Kabashima, Kenji Izuhara

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.12.001
  • The interplay between neuroendocrine activity and psychological
           stress-induced exacerbation of allergic asthma

    • Authors: Tomomitsu Miyasaka; Kaori Dobashi-Okuyama; Tomoko Takahashi; Motoaki Takayanagi; Isao Ohno
      Pages: 32 - 42
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Tomomitsu Miyasaka, Kaori Dobashi-Okuyama, Tomoko Takahashi, Motoaki Takayanagi, Isao Ohno
      Psychological stress is recognized as a key factor in the exacerbation of allergic asthma, whereby brain responses to stress act as immunomodulators for asthma. In particular, stress-induced enhanced type 2 T-helper (Th2)-type lung inflammation is strongly associated with asthma pathogenesis. Psychological stress leads to eosinophilic airway inflammation through activation of the hypothalamic-pituitary-adrenal pathway and autonomic nervous system. This is followed by the secretion of stress hormones into the blood, including glucocorticoids, epinephrine, and norepinephrine, which enhance Th2 and type 17 T-helper (Th17)-type asthma profiles in humans and rodents. Recent evidence has shown that a defect of the μ-opioid receptor in the brain along with a defect of the peripheral glucocorticoid receptor signaling completely disrupted stress-induced airway inflammation in mice. This suggests that the stress response facilitates events in the central nervous and endocrine systems, thus exacerbating asthma. In this review, we outline the recent findings on the interplay between stress and neuroendocrine activities followed by stress-induced enhanced Th2 and Th17 immune responses and attenuated regulatory T (Treg) cell responses that are closely linked with asthma exacerbation. We will place a special focus on our own data that has emphasized the continuity from central sensing of psychological stress to enhanced eosinophilic airway inflammation. The mechanism that modulates psychological stress-induced exacerbation of allergic asthma through neuroendocrine activities is thought to involve a series of consecutive pathological events from the brain to the lung, which implies there to be a “neuropsychiatry phenotype” in asthma.

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.04.013
  • The optimal age for epicutaneous sensitization following tape-stripping in
           BALB/c mice

    • Authors: Masato Tamari; Keisuke Orimo; Kenichiro Motomura; Ken Arae; Susumu Nakae; Akio Matsuda; Hideaki Morita; Hirohisa Saito; Kenji Matsumoto
      Abstract: Publication date: Available online 10 February 2018
      Source:Allergology International
      Author(s): Masato Tamari, Keisuke Orimo, Kenichiro Motomura, Ken Arae, Akio Matsuda, Susumu Nakae, Hirohisa Saito, Hideaki Morita, Kenji Matsumoto
      Background Direct contact of food proteins with eczematous lesions is thought to be the main cause of epicutaneous sensitization. To further investigate the development and pathogenesis of food allergy in vivo, a good mouse model of epicutaneous sensitization is needed. However, a fundamental problem in that regard is that the optimal age for epicutaneous sensitization of mice is unknown. In this study, we attempted to elucidate that optimal age. Methods Dorsal skin of wild-type BALB/c female mice (1, 3, 8 and 24 weeks old) was shaved, depilated and tape-stripped. A Finn chamber containing a 20-μl-aliquot of 20-mg/ml (OVA) was applied to the tape-stripped skin on 3 consecutive days/week, for 3 weeks. The body temperature was measured after intraperitoneal OVA challenge. Serum OVA-specific IgE titers and OVA-induced cytokine production by spleen cells were measured by ELISA. Dendritic cells (DCs) that migrated to the draining lymph nodes were quantified by FITC-labeled OVA and flow cytometry. The mRNA expression levels in the dorsal skin were measured by qPCR. Results A significant age-dependent body temperature decline was observed after OVA challenge. The serum OVA-specific IgE titer, OVA-induced cytokine production (i.e., IL-4, IL-5 and IL-13) by spleen cells, and number of FITC-OVA-engulfing DCs increased with age. In addition, mRNA for IL-33, but not TSLP or IL-25, was significantly induced in the skin by tape-stripping and increased with age. Conclusions Twenty-four-week-old mice showed the greatest DC migration, Th2 polarization, IgE production and body temperature decline. Skin-derived IL-33 is likely to play key roles in those changes.

      PubDate: 2018-02-13T10:09:03Z
      DOI: 10.1016/j.jaci.2017.12.469
  • Severe asthma concomitant with allergic bronchopulmonary aspergillosis
           successfully treated with mepolizumab

    • Authors: Naohiro Oda; Nobuaki Miyahara; Satoru Senoo; Junko Itano; Akihiko Taniguchi; Daisuke Morichika; Utako Fujii; Yoshinobu Maeda; Katsuyuki Kiura; Arihiko Kanehiro
      Abstract: Publication date: Available online 14 April 2018
      Source:Allergology International
      Author(s): Naohiro Oda, Nobuaki Miyahara, Satoru Senoo, Junko Itano, Akihiko Taniguchi, Daisuke Morichika, Utako Fujii, Yoshinobu Maeda, Katsuyuki Kiura, Arihiko Kanehiro

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.03.004
  • The relationship between complement levels and disease activity in
           Japanese family cases of hereditary angioedema with C1-INH deficiency

    • Authors: Atsushi Fukunaga; Shinji Tsuchiyama; Kasumi Lee; Ken Washio; Chinami Hashimura; Takahiko Horiuchi; Chikako Nishigori
      Abstract: Publication date: Available online 13 April 2018
      Source:Allergology International
      Author(s): Atsushi Fukunaga, Shinji Tsuchiyama, Kasumi Lee, Ken Washio, Chinami Hashimura, Takahiko Horiuchi, Chikako Nishigori

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.03.002
  • Possible involvement of acetylcholine-mediated inflammation in airway

    • Authors: Akira Koarai; Masakazu Ichinose
      Abstract: Publication date: Available online 28 March 2018
      Source:Allergology International
      Author(s): Akira Koarai, Masakazu Ichinose
      Inhaled bronchodilator treatment with a long acting muscarinic antagonist (LAMA) reduces symptoms and the risk of exacerbations in COPD and asthma. However, increasing evidence from cell culture and animal studies suggests that anti-muscarinic drugs could also possess anti-inflammatory effects. Recent studies have revealed that acetylcholine (ACh) can be synthesized and released from both neuronal and non-neuronal cells, and the released ACh can potentiate airway inflammation and remodeling in airway diseases. However, these anti-inflammatory effects of anti-muscarinic drugs have not yet been confirmed in COPD and asthma patients. This review will focus on recent findings about the possible involvement of ACh in airway inflammation and remodeling, and the anti-inflammatory effect of anti-muscarinic drugs in airway diseases. Clarifying the acetylcholine-mediated inflammation could provide insights into the mechanisms of airway diseases, which could lead to future therapeutic strategies for inhibiting the disease progression and exacerbations.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.02.008
  • TARC expression in the circulation and cutaneous granulomas correlates
           with disease severity and indicates Th2-mediated progression in patients
           with sarcoidosis

    • Authors: Chuyen Thi Hong Nguyen; Naotomo Kambe; Ikuko Ueda-Hayakawa; Izumi Kishimoto; Nhung Thi My Ly; Kana Mizuno; Hiroyuki Okamoto
      Abstract: Publication date: Available online 26 March 2018
      Source:Allergology International
      Author(s): Chuyen Thi Hong Nguyen, Naotomo Kambe, Ikuko Ueda-Hayakawa, Izumi Kishimoto, Nhung Thi My Ly, Kana Mizuno, Hiroyuki Okamoto
      Background Sarcoidosis is a systemic disorder characterized by the accumulation of lymphocytes and monocyte/macrophage lineage cells that results in the formation of non-caseating granulomas. Thymus- and activation-regulated chemokine (TARC)/CCL17 is an important chemokine in the amplification of Th2 responses, which are achieved by recruiting CCR4-expressing CD4+ T lymphocytes. TARC concentrations are known to increase in the serum of sarcoidosis patients; however, its role in the assessment of severity and prognosis of sarcoidosis remains unknown. The objective of this study is to elucidate the role of TARC in sarcoidosis by investigating its expression in peripheral blood and at inflammatory sites. We also examined its relationship with clinical features. Methods Serum levels of TARC, soluble interleukin 2 receptor, angiotensin-converting enzyme, and lysozyme were measured in 82 sarcoidosis patients. The Th1 and Th2 balance in circulating CD4+ T cells was evaluated by flow cytometry. The immunohistochemical staining of TARC and CCR4 was performed in order to identify the source of TARC in affected skin tissues. Results TARC serum levels were elevated in 78% of patients and correlated with disease severity. The percentage of CCR4+ cells and the CCR4+/CXCR3+ cell ratios were significantly higher in sarcoidosis patients than in normal subjects (P = 0.002 and P = 0.015, respectively). Moreover, TARC was expressed by monocyte/macrophage lineage cells within granulomas. The abundancy as well as distribution of TARC staining correlated with its serum levels. Conclusions The present results suggest that elevations in TARC drive an imbalanced Th2- weighted immune reaction and might facilitate prolonged inflammatory reactions in sarcoidosis.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.02.011
  • A rare case of drug-induced hypersensitivity syndrome by pirfenidone for
           idiopathic pulmonary fibrosis

    • Authors: Kumiko Suda; Koji Kamiya; Binluen Chiang; Hirofumi Okada; Naoko Mato; Takeo Maekawa; Mayumi Komine; Satoru Murata; Mamitaro Ohtsuki
      Abstract: Publication date: Available online 24 March 2018
      Source:Allergology International
      Author(s): Kumiko Suda, Koji Kamiya, Binluen Chiang, Hirofumi Okada, Naoko Mato, Takeo Maekawa, Mayumi Komine, Satoru Murata, Mamitaro Ohtsuki

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.02.010
  • Association between impaired IL-10 production following exposure to
           Staphylococcus aureus enterotoxin B and disease severity in eosinophilic
           chronic rhinosinusitis

    • Authors: Takenori Haruna; Shin Kariya; Tazuko Fujiwara; Takaya Higaki; Seiichiro Makihara; Kengo Kanai; Rumi Fujiwara; Satoshi Iwasaki; Yoshihiro Noguchi; Kazunori Nishizaki; Mitsuhiro Okano
      Abstract: Publication date: Available online 23 March 2018
      Source:Allergology International
      Author(s): Takenori Haruna, Shin Kariya, Tazuko Fujiwara, Takaya Higaki, Seiichiro Makihara, Kengo Kanai, Rumi Fujiwara, Satoshi Iwasaki, Yoshihiro Noguchi, Kazunori Nishizaki, Mitsuhiro Okano
      Background IL-10 is a major anti-inflammatory cytokine that prevents inflammation-mediated tissue damage. We characterized the production of IL-10 by sinonasal tissue cells following exposure to Staphylococcus aureus enterotoxin B (SEB), which elicits cellular responses and is associated with the pathogenesis of eosinophilic chronic rhinosinusitis (ECRS). Methods Dispersed nasal polyp (NP) cells and uncinate tissue (UT) cells were prepared from patients with CRS with and without NP, respectively. Cells were incubated with SEB, and then the levels of IL-10 in the cell supernatants were determined. The effect of neutralizing IL-10 on SEB-induced IL-5, IL-13, IFN-γ, and IL-17A production was examined. Expression of IL-10 in NPs was also determined. Results IL-10 was expressed in infiltrating inflammatory cells in NPs. NP cells, especially non-adherent NP cells, produced substantial amounts of IL-10 in response to SEB. Although baseline production of IL-10 was significantly higher in NP cells than UT cells, the degree of IL-10 response to SEB was not significantly different between the cell types. The degree of IL-10 production was negatively correlated with the degree of eosinophilia both in tissues and peripheral blood whereas positively correlated with the 1-s forced expiratory volume/forced vital capacity ratio. Patients with severe ECRS displayed a significant decrease in IL-10 production compared with those with non-ECRS. IL-10 neutralization significantly augmented SEB-induced IL-13 and IFN-γ production by NP cells. Conclusions Impaired IL-10 production in response to SEB in NP may exacerbate the pathophysiology of ECRS including eosinophilia and lower airway obstruction.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.02.001
  • Nationwide questionnaire-based survey of oral immunotherapy in Japan

    • Authors: Sakura Sato; Chizuko Sugizaki; Noriyuki Yanagida; Komei Ito; Yusei Ohshima; Naoki Shimojo; Takao Fujisawa; Motohiro Ebisawa
      Abstract: Publication date: Available online 20 March 2018
      Source:Allergology International
      Author(s): Sakura Sato, Chizuko Sugizaki, Noriyuki Yanagida, Komei Ito, Yusei Ohshima, Naoki Shimojo, Takao Fujisawa, Motohiro Ebisawa
      Background Clinical trials on oral immunotherapy (OIT) have been increasing for nearly a decade; however, several national guidelines do not recommend OIT as a standardized procedure. The aim of this study was to obtain insights into the current use and practice of OIT in Japan. Methods A first questionnaire was mailed to 524 training and teaching facilities of the Japan Pediatric Society. The first survey requested information on the implementation of OIT, whereas the second survey aimed to gather more detailed information on OIT, such as its safety. Results In total, 360 facilities (69%) responded to the survey; among them, 102 (28%) provided OIT to 7973 patients [1544 received OIT while hospitalized (inpatient OIT), whereas 6429 received OIT without hospitalization (outpatient OIT)]. Approval for OIT was obtained from an ethics committee or institutional review board in 89% and 31% of facilities for inpatient and outpatient OIT, respectively. In inpatient OIT, immediate allergic reactions requiring treatment occurred in 68% of patients while hospitalized, and in another 56%, following discharge. In contrast, 11% of patients developed immediate allergic reactions in outpatient OIT. Adrenaline injections at home were required in 2%. Sixteen patients developed adverse reactions other than immediate allergic reactions, among which eosinophilic gastroenteritis was most common. Conclusions OIT is widely provided not only as clinical research but also as general practice in Japan. However, because there is a high risk of developing anaphylaxis at home, OIT should be conducted carefully as in a clinical research setting taking safety into consideration.

      PubDate: 2018-04-15T15:27:13Z
      DOI: 10.1016/j.alit.2018.02.006
  • The efficacy of sublingual immunotherapy for allergic diseases in Asia

    • Authors: Xuandao Liu; Chew Lip Yun Wang
      Abstract: Publication date: Available online 16 March 2018
      Source:Allergology International
      Author(s): Xuandao Liu, Chew Lip Ng, De Yun Wang
      Sublingual immunotherapy (SLIT) has been proven to be safe and effective from an abundance of Western literature, but data from Asia is less complete. This review aims to examine the basic science, safety and efficacy of SLIT in Asian patients, and to determine future research needs in Asia. We performed a literature search on PUBMED, Scopus, and Cochrane Library database for articles on SLIT originating from Asian countries through Nov 2017. There were 18 randomized, double-blind, placebo-controlled trials, of which 9 involved solely paediatric subjects. Overall, sublingual immunotherapy is safe and is efficacious in Asian populations in allergic rhinitis (AR) and asthma. House dust-mite SLIT is effective in both mono- and polysensitized AR patients. Efficacy of SLIT is comparable to subcutaneous immunotherapy. Data on long term efficacy is lacking. A disproportionate majority of research originates from China and Japan, reflecting an asymmetry of access to SLIT within Asia. Significant disparities exist in the development of the allergy speciality, prescription patterns of SLIT, and pharmacological potencies of different SLIT products within and between Asian nations. We conclude that current available evidence suggests SLIT is efficacious in Asians but data quality of evidence is hampered by non-placebo controlled studies with methodological limitations. More data is needed in South and Southeast Asian populations. Future efforts may be directed towards improving access to SLIT in developing countries, standardization of SLIT dosage, and evaluating long term clinical outcomes.

      PubDate: 2018-03-17T12:53:41Z
  • Epidemiology of asthma-chronic obstructive pulmonary disease overlap (ACO)

    • Authors: Akifumi Uchida; Kohta Sakaue; Hiromasa Inoue
      Abstract: Publication date: Available online 15 March 2018
      Source:Allergology International
      Author(s): Akifumi Uchida, Kohta Sakaue, Hiromasa Inoue
      The term “asthma-COPD overlap” (ACO) has been applied to the condition in which a person has persistent airflow limitation with clinical features of both asthma and COPD. The certain definition and diagnostic criteria for ACO have not yet been established, and ACO prevalence has varied widely in studies: from 0.9% to 11.1% in the general population, from 11.1% to 61.0% in asthma patients, and from 4.2% to 66.0% in COPD patients. Furthermore, the frequency of exacerbations and prognosis in ACO patients have not been clearly demonstrated. Although ACO consists with several subgroups of patients with distinct clinical and pathophysiological features, it would be important to propose a standardized definition of and/or diagnostic criteria for ACO based on biomarkers and objective measures, even if it is tentative. It may lead cohort studies with large population or clinical trials around the world.

      PubDate: 2018-03-17T12:53:41Z
      DOI: 10.1016/j.alit.2018.02.002
  • Asthma and COPD overlap pathophysiology of ACO

    • Authors: Mari Hikichi; Shu Hashimoto; Yasuhiro Gon
      Abstract: Publication date: Available online 15 March 2018
      Source:Allergology International
      Author(s): Mari Hikichi, Shu Hashimoto, Yasuhiro Gon
      Asthma and COPD appear as a result of different mechanisms triggered by different pathogeneses and although they present different features and symptoms of airway inflammation and airway obstruction, there are also cases that present the features of both asthma and COPD. This type of pathology is known as asthma-COPD overlap syndrome (ACOS). Asthma-COPD overlap is identified in clinical practice by the features that it shares with both asthma and COPD. This is not a definition, but a description for clinical use, as asthma-COPD overlap includes several different clinical phenotypes and there are likely to be several different underlying mechanisms”. In this paper, the disease that shares several features of both asthma and COPD will be referred to as asthma-COPD overlap (ACO). In this article, we describe the pathogenesis of ACO for understanding the mechanism in asthma and COPD overlap.

      PubDate: 2018-03-17T12:53:41Z
      DOI: 10.1016/j.alit.2018.01.001
  • Identification of Cha o 3 homolog Cry j 4 from Cryptomeria japonica
           (Japanese cedar) pollen: Limitation of the present Japanese
           cedar–specific ASIT

    • Authors: Toshihiro Osada; Yuki Tanaka; Akira Yamada; Eiji Sasaki; Teruhiro Utsugi
      Abstract: Publication date: Available online 7 March 2018
      Source:Allergology International
      Author(s): Toshihiro Osada, Yuki Tanaka, Akira Yamada, Eiji Sasaki, Teruhiro Utsugi
      Background About one-third of the Japanese population suffers from Japanese cedar pollinosis, which is frequently accompanied by Japanese cypress pollinosis. Recently, a novel major Japanese cypress pollen allergen, Cha o 3, was discovered. However, whether a Cha o 3 homolog is present in Japanese cedar pollen remains to be determined. Methods Western blot analysis was performed using Cha o 3–specific antiserum. In addition, cloning of the gene encoding Cry j 4 was conducted using total cDNA from the male flower of Japanese cedar trees. Allergen potency and cross-reactivity were investigated using a T-cell proliferation assay, basophil activation test, and ImmunoCAP inhibition assay. Results A low amount of Cha o 3 homolog protein was detected in Japanese cedar pollen extract. The deduced amino acid sequence of Cry j 4 showed 84% identity to that of Cha o 3. Cross-reactivity between Cry j 4 and Cha o 3 was observed at the T cell and IgE levels. Conclusions Cry j 4 was discovered as a counterpart allergen of Cha o 3 in Japanese cedar pollen, with a relationship similar to that between Cry j 1–Cha o 1 and Cry j 2–Cha o 2. Our findings also suggest that allergen-specific immunotherapy (ASIT) using Japanese cedar pollen extract does not induce adequate immune tolerance to Cha o 3 due to the low amount of Cry j 4 in Japanese cedar pollen. Therefore, ASIT using Cha o 3 or cypress pollen extract coupled with Japanese cedar pollen extract is required in order to optimally control allergy symptoms during Japanese cypress pollen season.

      PubDate: 2018-03-17T12:53:41Z
      DOI: 10.1016/j.alit.2018.02.004
  • Involvement of taste receptors in the effectiveness of sublingual

    • Authors: Minoru Gotoh; Osamu Kaminuma; Akihiro Nakaya; Kazufumi Katayama; Nobumasa Watanabe; Mayumi Saeki; Tomoe Nishimura; Noriko Kitamura; Kimihiro Okubo; Takachika Hiroi
      Abstract: Publication date: Available online 6 March 2018
      Source:Allergology International
      Author(s): Minoru Gotoh, Osamu Kaminuma, Akihiro Nakaya, Kazufumi Katayama, Nobumasa Watanabe, Mayumi Saeki, Tomoe Nishimura, Noriko Kitamura, Kimihiro Okubo, Takachika Hiroi

      PubDate: 2018-03-17T12:53:41Z
      DOI: 10.1016/j.alit.2018.02.003
  • Anaphylaxis caused by a centipede bite: A “true” type-I
           allergic reaction

    • Authors: Ken Washio; Taro Masaki; Shotaro Fujii; Mayumi Hatakeyama; Yoshiko Oda; Atsushi Fukunaga; Masaru Natsuaki
      Abstract: Publication date: Available online 5 March 2018
      Source:Allergology International
      Author(s): Ken Washio, Taro Masaki, Shotaro Fujii, Mayumi Hatakeyama, Yoshiko Oda, Atsushi Fukunaga, Masaru Natsuaki

      PubDate: 2018-03-06T11:57:10Z
      DOI: 10.1016/j.alit.2018.01.005
  • Influence of topical steroids on intraocular pressure in patients with
           atopic dermatitis

    • Authors: Risa Tamagawa-Mineoka; Naoko Yasuoka; Mayumi Ueta; Norito Katoh
      Abstract: Publication date: Available online 16 February 2018
      Source:Allergology International
      Author(s): Risa Tamagawa-Mineoka, Naoko Yasuoka, Mayumi Ueta, Norito Katoh
      Background Topical corticosteroids (TCS) can induce adverse effects, such as skin atrophy. Although TCS can cause increases in intraocular pressure (IOP), the effects of daily TCS use on IOP have not been fully elucidated. We evaluated the clinical doses of TCS and the change in the IOP during the daily treatment of atopic dermatitis (AD). Methods We collected clinical data on a total of 65 patients who were diagnosed with AD and underwent 2 or more IOP measurements at our hospital. Results Mean monthly facial steroid volumes of ≤11.8 g and ≤15.0 g of TCS were applied to 90% of the patients aged 2–12 years and those aged ≥13 years, respectively. During the treatment, there were no TCS-related increases in IOP in any patient. Conclusions Our study suggests that TCS might not cause increases in IOP at the abovementioned doses. However, the IOP of steroid responders is known to be highly responsive to steroids. Therefore, patients who have steroids applied to their eyelids had better undergo regular IOP measurements at ophthalmological clinics.

      PubDate: 2018-02-24T11:06:34Z
      DOI: 10.1016/j.alit.2018.01.004
  • Efficacy of tiotropium in adults with moderate asthma, by leukotriene
           receptor antagonist use at baseline

    • Authors: Shu Hashimoto; Thomas B. Casale; Michael Engel; Petra Moroni-Zentgraf; Louis J. Bour; Huib A.M. Kerstjens
      Abstract: Publication date: Available online 15 February 2018
      Source:Allergology International
      Author(s): Shu Hashimoto, Thomas B. Casale, Michael Engel, Petra Moroni-Zentgraf, Louis J. Bour, Huib A.M. Kerstjens

      PubDate: 2018-02-24T11:06:34Z
      DOI: 10.1016/j.alit.2017.12.002
  • Efficacy and safety of emedastine patch, a novel transdermal drug delivery
           system for allergic rhinitis: Phase III, multicenter, randomized,
           double-blinded, placebo-controlled, parallel-group comparative study in
           patients with seasonal allergic rhinitis

    • Authors: Kimihiro Okubo; Eiji Uchida; Takaaki Terahara; Katsuhiko Akiyama; Shigeo Kobayashi; Yusuke Tanaka
      Abstract: Publication date: Available online 13 February 2018
      Source:Allergology International
      Author(s): Kimihiro Okubo, Eiji Uchida, Takaaki Terahara, Katsuhiko Akiyama, Shigeo Kobayashi, Yusuke Tanaka
      Background Emedastine patch was developed in Japan as the first transdermal drug delivery system of emedastine difumarate for allergic rhinitis. Methods A multicenter, randomized, double-blind, placebo-controlled, parallel-group comparison was conducted in patients with seasonal allergic rhinitis. Patients were administered emedastine patches (4 or 8 mg), placebo, or levocetirizine hydrochloride (5 mg tablet) once daily for 2 weeks (double-dummy technique). The primary objective was superiority to placebo by the change of the total nasal symptom score (sneezing, rhinorrhea, and nasal congestion) in Week 2. Levocetirizine was a reference drug and not a comparator in this study. Results A total of 1276 patients were randomized to receive the 4 mg emedastine patch (n = 384), 8 mg emedastine patch (n = 382), placebo (n = 384), or levocetirizine (n = 126). The least squares mean (LSM) of the change from baseline of the total nasal symptom score (TNSS) in Week 2 was significantly larger in both emedastine patch groups than in the placebo group (adjusted p < 0.0001). In secondary analysis, LSM of the change in the TNSS was −1.20, −1.49, −0.44, and −1.32 in the 4 mg emedastine patch, 8 mg patch, placebo, and levocetirizine, respectively. Reductions in the number of episodes and scores of individual nasal symptoms were all significantly larger throughout the day in the emedastine patch groups than the placebo group (all p < 0.05). No clinically significant safety problems occurred. Conclusions Emedastine patch (4 and 8 mg) effectively and safely controlled symptoms of seasonal allergic rhinitis with sustained action throughout the day. Study registration: JapicCTI-153092.

      PubDate: 2018-02-24T11:06:34Z
      DOI: 10.1016/j.alit.2017.12.005
  • Long-term management and persistent impairment of pulmonary function in
           chronic eosinophilic pneumonia: A review of the previous literature

    • Authors: Yuzo Suzuki; Takafumi Suda
      Abstract: Publication date: Available online 13 February 2018
      Source:Allergology International
      Author(s): Yuzo Suzuki, Takafumi Suda
      Chronic eosinophilic pneumonia (CEP) is an inflammatory disease characterized by accumulations of eosinophils in the lung with unknown etiology. Although corticosteroid treatment dramatically resolves these inflammations, relapse is common during the course of the disease. Approximately 50% of patients with CEP experience relapse. Subsequent to persistent disease and repeated relapse, and in cases of combined severe asthma, some CEP patients are administered corticosteroids indefinitely. Similar to patients with severe asthma who are often steroid dependent, a number of CEP patients exhibit prolonged persistent impairment of pulmonary function. Thus, CEP should be considered a potentially chronic disease requiring long-term management, rather than an acute or sub-acute disease requiring short-time therapy only. This review summarizes previous CEP studies, as well as our own cohort data, and discusses the long-term management of CEP with a particular focus on relapse, the prevalence of maintenance therapy, and persistent impairment of pulmonary function.

      PubDate: 2018-02-24T11:06:34Z
      DOI: 10.1016/j.alit.2017.12.004
  • Definition and diagnosis of asthma–COPD overlap (ACO)

    • Authors: Satoru Yanagisawa; Masakazu Ichinose
      Abstract: Publication date: Available online 9 February 2018
      Source:Allergology International
      Author(s): Satoru Yanagisawa, Masakazu Ichinose
      It is now widely recognized that asthma and COPD can coexist as asthma–COPD overlap (ACO), but the preliminary attempts at providing universal guidelines for the diagnosis of ACO still need to be improved. We believe that a case can be made for devising guidelines for the diagnosis of this increasingly common disease that are specific to Japan. In this paper, we present our consensus-based description of ACO which we believe is realistic for use in our country. In addition, we cite the scientific evidence for our own “objective” features used to develop the criteria for COPD and asthma diagnosis. We acknowledge that they will need to be validated and updated over time, but hope the results will encourage further research on the characteristics and treatment of this commonly encountered clinical problem.

      PubDate: 2018-02-13T10:09:03Z
      DOI: 10.1016/j.alit.2018.01.002
  • A case of contact dermatitis and contact urticaria syndrome due to
           multiple allergens observed in a professional baseball player

    • Authors: Kaoru Nishiwaki; Yuka Matsumoto; Kosuke Kishida; Muneaki Kaku; Ryoji Tsuboi; Yukari Okubo
      Abstract: Publication date: Available online 1 February 2018
      Source:Allergology International
      Author(s): Kaoru Nishiwaki, Yuka Matsumoto, Kosuke Kishida, Muneaki Kaku, Ryoji Tsuboi, Yukari Okubo

      PubDate: 2018-02-13T10:09:03Z
      DOI: 10.1016/j.alit.2017.12.003
  • Aquagenic urticaria: Severe extra-cutaneous symptoms following cold water

    • Authors: Takeshi Fukumoto; Kanako Ogura; Atsushi Fukunaga; Chikako Nishigori
      Abstract: Publication date: Available online 9 January 2018
      Source:Allergology International
      Author(s): Takeshi Fukumoto, Kanako Ogura, Atsushi Fukunaga, Chikako Nishigori

      PubDate: 2018-01-10T10:38:05Z
      DOI: 10.1016/j.alit.2017.10.007
  • Recent advancement to prevent the development of allergy and allergic
           diseases and therapeutic strategy in the perspective of barrier

    • Authors: Osamu Natsume; Yukihiro Ohya
      Abstract: Publication date: Available online 7 December 2017
      Source:Allergology International
      Author(s): Osamu Natsume, Yukihiro Ohya
      Therapeutic strategy in late 20th century to prevent allergic diseases was derived from a conceptual framework of allergens elimination which was as same as that of coping with them after their onset. Manifold trials were implemented; however, most of them failed to verify the effectiveness of their preventive measures. Recent advancement of epidemiological studies and cutaneous biology revealed epidermal barrier dysfunction plays a major role of allergen sensitization and development of atopic dermatitis which ignites the inception of allergy march. For this decade, therapeutic strategy to prevent the development of food allergy has been confronted with a paradigm shift from avoidance and delayed introduction of allergenic foods based on the theoretical concept to early introduction of them based on the clinical and epidemiological evidences. Especially, prevention of peanut allergy and egg allergy has been established with the highest evidence verified by randomized controlled trials, although application in clinical practice should be done with attention. This paradigm shift concerning food allergy was also due to the discovery of cutaneous sensitization risk of food allergens for an infant with eczema revealed by prospective studies. Here we have recognized the increased importance of prevention of eczema/atopic dermatitis in infancy. Two randomized controlled trials using emollients showed successful results in prevention of atopic dermatitis in infancy; however, longer term safety and prognosis including allergy march should be pursued. To establish more fundamental strategy for prevention of the development of allergy, further studies clarifying the mechanisms of interaction between barrier dysfunction and microbial milieu are needed with macroscope to understand the relationship between allergic diseases and a diversity of environmental influences.

      PubDate: 2017-12-08T17:51:31Z
      DOI: 10.1016/j.alit.2017.11.003
  • Barrier dysfunction in the skin allergy

    • Authors: Gyohei Egawa; Kenji Kabashima
      Abstract: Publication date: Available online 16 November 2017
      Source:Allergology International
      Author(s): Gyohei Egawa, Kenji Kabashima
      The skin is continuously exposed to external pathogens, and its barrier function is critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one of the most predisposing factors for the development of skin allergic diseases such as atopic dermatitis. In this article, we summarize how the physical barrier of the skin is organized and review its link to the pathomechanism of skin allergic diseases. We describe the formation of the SC barrier in terms of the following five categories: 1) filaggrin metabolism; 2) cornified envelope; 3) intercellular lipids; 4) corneodesmosome; and 5) corneocyte desquamation. New approaches to restoring the skin barrier function are also discussed.

      PubDate: 2017-12-08T17:51:31Z
      DOI: 10.1016/j.alit.2017.10.002
  • Barrier dysfunction in the nasal allergy

    • Authors: Ayumi Fukuoka; Tomohiro Yoshimoto
      Abstract: Publication date: Available online 14 November 2017
      Source:Allergology International
      Author(s): Ayumi Fukuoka, Tomohiro Yoshimoto
      Epithelial cells form the first physiological barrier against invasion by pathogens and the infiltration of allergens. Tight junctions (TJ), a cell–cell junctional complex located on the apical side of epithelial cells, have a critical role in the maintenance of epithelial barrier function. Impaired TJ structures are observed in patients with asthma, atopic dermatitis and nasal allergy; therefore, the dysfunction of epithelial barriers might be involved in the initiation or progression of allergic diseases. Protease-containing allergens and environmental pollutants enhance paracellular transport in epithelial cells through disruption of epithelial barrier function. This suggests that the disruption of TJ leads to the promotion of allergen delivery into the subepithelia, resulting in the progression of allergic diseases. Thus, protection of the epithelial barrier function might prevent or inhibit the development or exacerbation of allergic diseases. Recently, we reported that diesel exhaust particles (DEP), the main component of particulate patter 2.5, exacerbated allergic rhinitis (AR) in a mouse model through TJ disruption. In addition, we revealed that the oxidative stress-mediated pathway is involved in the effects caused by DEP and that nasal treatment with a reactive oxygen species (ROS) scavenger suppressed DEP-induced TJ disruption and exacerbation of AR. In this review, we focus on the relationship between TJ disruption and allergic disease. Furthermore, we discuss our recent findings regarding TJ disruption and the exacerbation of AR.

      PubDate: 2017-11-17T06:25:22Z
      DOI: 10.1016/j.alit.2017.10.006
  • Role of airway epithelial barrier dysfunction in pathogenesis of asthma

    • Authors: Yasuhiro Gon; Shu Hashimoto
      Abstract: Publication date: Available online 21 September 2017
      Source:Allergology International
      Author(s): Yasuhiro Gon, Shu Hashimoto
      Bronchial asthma is characterized by persistent cough, increased sputum, and repeated wheezing. The pathophysiology underlying these symptoms is the hyper-responsiveness of the airway along with chronic airway inflammation. Repeated injury, repair, and regeneration of the airway epithelium following exposure to environmental factors and inflammation results in histological changes and functional abnormalities in the airway mucosal epithelium; such changes are believed to have a significant association with the pathophysiology of asthma. Damage to the barrier functions of the airway epithelium enhances mucosal permeability of foreign substances in the airway epithelium of patients with asthma. Thus, epithelial barrier fragility is closely involved in releasing epithelial cytokines (e.g., TSLP, IL-25, and IL-33) because of the activation of airway epithelial cells, dendritic cells, and innate group 2 innate lymphoid cells (ILC2). Functional abnormalities of the airway epithelial cells along with the activation of dendritic cells, Th2 cells, and ILC2 form a single immunopathological unit that is considered to cause allergic airway inflammation. Here we use the latest published literature to discuss the potential pathological mechanisms regarding the onset and progressive severity of asthma with regard to the disruption of the airway epithelial function.

      PubDate: 2017-09-24T04:28:02Z
      DOI: 10.1016/j.alit.2017.08.011
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