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Showing 1 - 200 of 3120 Journals sorted alphabetically
A Practical Logic of Cognitive Systems     Full-text available via subscription   (Followers: 8)
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 26, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 22, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 90, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 25, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 30, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 4)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 5, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 378, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 3)
Acta Biomaterialia     Hybrid Journal   (Followers: 26, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 1)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (Followers: 1, SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 237, SJR: 3.683, h-index: 202)
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Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 10, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription   (Followers: 1)
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Acta Pharmaceutica Sinica B     Open Access   (Followers: 2)
Acta Poética     Open Access   (Followers: 4)
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Acta Sociológica     Open Access  
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Acta Urológica Portuguesa     Open Access  
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Acupuncture and Related Therapies     Hybrid Journal   (Followers: 5)
Acute Pain     Full-text available via subscription   (Followers: 13)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 7)
Additive Manufacturing     Hybrid Journal   (Followers: 7, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 22)
Advanced Cement Based Materials     Full-text available via subscription   (Followers: 3)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 140, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 17, SJR: 0.739, h-index: 33)
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Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
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Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 9, SJR: 1.268, h-index: 45)
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Advances in Digestive Medicine     Open Access   (Followers: 7)
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Advances in Drug Research     Full-text available via subscription   (Followers: 23)
Advances in Ecological Research     Full-text available via subscription   (Followers: 47, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 27, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 9)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 46, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 3)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 52, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 16)
Advances in Genetics     Full-text available via subscription   (Followers: 17, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
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Advances in Heat Transfer     Full-text available via subscription   (Followers: 22, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 0.497, h-index: 31)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 27)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 36, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 3, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 4)
Advances in Life Course Research     Hybrid Journal   (Followers: 8, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 2)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 10)
Advances in Marine Biology     Full-text available via subscription   (Followers: 16, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 5, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 23)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 10)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 9, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 4)
Advances in Oncobiology     Full-text available via subscription   (Followers: 2)
Advances in Organ Biology     Full-text available via subscription   (Followers: 2)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 24, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 13)
Advances in Pharmacology     Full-text available via subscription   (Followers: 16, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 7)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20, SJR: 1.5, h-index: 62)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 6, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.1, h-index: 2)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 5)
Advances in Space Research     Full-text available via subscription   (Followers: 371, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 8)
Advances in Surgery     Full-text available via subscription   (Followers: 9, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 31, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 16)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 6, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 45, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 5, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 338, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 6, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 9, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 433, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 31, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 42, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access  
Agriculture and Natural Resources     Open Access   (Followers: 3)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 56, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 5, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 11, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 8)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access   (Followers: 1)
Algal Research     Partially Free   (Followers: 9, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 4, SJR: 0.776, h-index: 35)
Alpha Omegan     Full-text available via subscription   (SJR: 0.121, h-index: 9)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 9, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 49, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 4)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 4)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 5)
American Heart J.     Hybrid Journal   (Followers: 48, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 48, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 42, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 9, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 32, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 26, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 31, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 45, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 207, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 61, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 6)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 24, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 27, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 26, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 36, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 6)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 60, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 14)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 4, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 36, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 173, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 8, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 12)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 1)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 22, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access  
Animal Behaviour     Hybrid Journal   (Followers: 176, SJR: 1.907, h-index: 126)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 5, SJR: 1.151, h-index: 83)

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Journal Cover Allergology International
  [SJR: 0.776]   [H-I: 35]   [4 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 1323-8930 - ISSN (Online) 1440-1592
   Published by Elsevier Homepage  [3123 journals]
  • Barrier dysfunction in allergy

    • Authors: Kenji Kabashima; Kenji Izuhara
      Pages: 1 - 2
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Kenji Kabashima, Kenji Izuhara

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.12.001
  • The interplay between neuroendocrine activity and psychological
           stress-induced exacerbation of allergic asthma

    • Authors: Tomomitsu Miyasaka; Kaori Dobashi-Okuyama; Tomoko Takahashi; Motoaki Takayanagi; Isao Ohno
      Pages: 32 - 42
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Tomomitsu Miyasaka, Kaori Dobashi-Okuyama, Tomoko Takahashi, Motoaki Takayanagi, Isao Ohno
      Psychological stress is recognized as a key factor in the exacerbation of allergic asthma, whereby brain responses to stress act as immunomodulators for asthma. In particular, stress-induced enhanced type 2 T-helper (Th2)-type lung inflammation is strongly associated with asthma pathogenesis. Psychological stress leads to eosinophilic airway inflammation through activation of the hypothalamic-pituitary-adrenal pathway and autonomic nervous system. This is followed by the secretion of stress hormones into the blood, including glucocorticoids, epinephrine, and norepinephrine, which enhance Th2 and type 17 T-helper (Th17)-type asthma profiles in humans and rodents. Recent evidence has shown that a defect of the μ-opioid receptor in the brain along with a defect of the peripheral glucocorticoid receptor signaling completely disrupted stress-induced airway inflammation in mice. This suggests that the stress response facilitates events in the central nervous and endocrine systems, thus exacerbating asthma. In this review, we outline the recent findings on the interplay between stress and neuroendocrine activities followed by stress-induced enhanced Th2 and Th17 immune responses and attenuated regulatory T (Treg) cell responses that are closely linked with asthma exacerbation. We will place a special focus on our own data that has emphasized the continuity from central sensing of psychological stress to enhanced eosinophilic airway inflammation. The mechanism that modulates psychological stress-induced exacerbation of allergic asthma through neuroendocrine activities is thought to involve a series of consecutive pathological events from the brain to the lung, which implies there to be a “neuropsychiatry phenotype” in asthma.

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.04.013
  • Flow cytometry-based diagnosis of primary immunodeficiency diseases

    • Authors: Hirokazu Kanegane; Akihiro Hoshino; Tsubasa Okano; Takahiro Yasumi; Taizo Wada; Hidetoshi Takada; Satoshi Okada; Motoi Yamashita; Tzu-wen Yeh; Ryuta Nishikomori; Masatoshi Takagi; Kohsuke Imai; Hans D. Ochs; Tomohiro Morio
      Pages: 43 - 54
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Hirokazu Kanegane, Akihiro Hoshino, Tsubasa Okano, Takahiro Yasumi, Taizo Wada, Hidetoshi Takada, Satoshi Okada, Motoi Yamashita, Tzu-wen Yeh, Ryuta Nishikomori, Masatoshi Takagi, Kohsuke Imai, Hans D. Ochs, Tomohiro Morio
      Primary immunodeficiencies (PIDs) are a heterogeneous group of inherited diseases of the immune system. The definite diagnosis of PID is ascertained by genetic analysis; however, this takes time and is costly. Flow cytometry provides a rapid and highly sensitive tool for diagnosis of PIDs. Flow cytometry can evaluate specific cell populations and subpopulations, cell surface, intracellular and intranuclear proteins, biologic effects associated with specific immune defects, and certain functional immune characteristics, each being useful for the diagnosis and evaluation of PIDs. Flow cytometry effectively identifies major forms of PIDs, including severe combined immunodeficiency, X-linked agammaglobulinemia, hyper IgM syndromes, Wiskott-Aldrich syndrome, X-linked lymphoproliferative syndrome, familial hemophagocytic lymphohistiocytosis, autoimmune lymphoproliferative syndrome, IPEX syndrome, CTLA 4 haploinsufficiency and LRBA deficiency, IRAK4 and MyD88 deficiencies, Mendelian susceptibility to mycobacterial disease, chronic mucocuneous candidiasis, and chronic granulomatous disease. While genetic analysis is the definitive approach to establish specific diagnoses of PIDs, flow cytometry provides a tool to effectively evaluate patients with PIDs at relatively low cost.

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.06.003
  • Association of Japanese cedar pollinosis and sensitization with HLA-DPB1
           in the Japanese adolescent

    • Authors: Wataru Morii; Aiko Sakai; Takahiro Ninomiya; Masanori Kidoguchi; Ryo Sumazaki; Shigeharu Fujieda; Emiko Noguchi
      Pages: 61 - 66
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Wataru Morii, Aiko Sakai, Takahiro Ninomiya, Masanori Kidoguchi, Ryo Sumazaki, Shigeharu Fujieda, Emiko Noguchi
      Background Allergic rhinitis (AR) is a heterogeneous disorder that significantly affects daily activity, work productivity, sleep, learning, and quality of life in all generations. Japanese cedar (JC) pollen is the most common allergen responsible for the development of AR in Japan. AR caused by JC pollen is considered to be a multifactorial inheritance disease that is caused by both environmental and genetic factors. The aim of this study was to investigate whether Human Leukocyte Antigen-DPB1 (HLA-DPB1) is associated with JC sensitization/pollinosis. Methods Subjects in the present study were 544 students at the University of Tsukuba from 2013 to 2015. PCR-SSOP was performed to determine each individual's HLA-DPB1 alleles. Logistic regression analysis was performed to examine relationships between JC-related phenotypes and alleles/amino acid polymorphisms of HLA-DPB1. Results HLA-DPB1*02 allele were significantly associated with both JC sensitization/pollinosis (q < 0.05). Furthermore, HLA-DPB1*02:01 and HLA-DPB1*02:02 had a protective tendency for JC sensitization/pollinosis, and HLA-DPB1*05:01 had a susceptible tendency for sensitization (P < 0.05). In amino acid polymorphism analyses, Glutamic acid in position 69, Glycine-Glycine-Proline-Methionine in positions 84–87, Threonine in position 170 and Methionine in position 205 were also observed to have a protective tendency for JC sensitization (P < 0.05). Amino acid positions 69 and 84–87 were located in binding pocket 5 and 1 of HLA-DPβ1, respectively. Conclusions Amino acid changes in the allergen-binding pocket of HLA-DPβ1 are likely to influence pollinosis/sensitization to the allergenic peptide of JC pollen and determine the pollinosis risk for each individual exposed to JC pollen.

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.04.004
  • Skin prick test is more useful than specific IgE for diagnosis of
           buckwheat allergy: A retrospective cross-sectional study

    • Authors: Noriyuki Yanagida; Sakura Sato; Kyohei Takahashi; Ken-ichi Nagakura; Kiyotake Ogura; Tomoyuki Asaumi; Motohiro Ebisawa
      Pages: 67 - 71
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Noriyuki Yanagida, Sakura Sato, Kyohei Takahashi, Ken-ichi Nagakura, Kiyotake Ogura, Tomoyuki Asaumi, Motohiro Ebisawa
      Background Buckwheat (BW) is a potentially life-threatening allergen. Usefulness of BW-specific immunoglobulin-E (BW-sIgE) level for diagnosis of BW allergy is controversial, while the skin prick test (SPT) is widely used because of its less invasive procedure and immediate results. However, there are no data comparing usefulness of the SPT and BW-sIgE level. Therefore, our study aimed to clarify efficacy of the SPT for diagnosis of BW allergy. Methods This retrospective cross-sectional study evaluated patients who underwent an oral food challenge (OFC) for diagnosis or confirmation of acquired tolerance using 3072 mg of BW protein between July 2006 and April 2014. We then compared the diagnostic performance of BW sIgE and SPT to predict positive OFC results. Results We analyzed 126 patients aged 2–16 years (median, 7.7 years), 18 (14%) of whom showed positive OFC results. Between patients with positive and negative OFC results, there was no significant difference in BW-sIgE level. However, patients with positive OFC results had a larger SPT wheal diameter. Area under the curve for positive OFC results for BW-sIgE level and SPT wheal diameter were 0.583 and 0.791, respectively. The 5%, 10%, 50%, and 90% positive predictive values of SPT wheal diameter were 2.0 mm, 5.2 mm, 14.7 mm, and 24.1 mm, respectively. Conclusions Our study revealed that the SPT was more useful than BW-sIgE level for diagnosis of BW allergy. Thus, an OFC may be avoided if the patient's SPT wheal diameter is at least 24.1 mm.

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.04.005
  • Early control treatment with montelukast in preschool children with
           asthma: A randomized controlled trial

    • Authors: Mizuho Nagao; Masanori Ikeda; Norimasa Fukuda; Chizu Habukawa; Tetsuro Kitamura; Toshio Katsunuma; Takao Fujisawa; Kennichi Tokuyama; Akihiko Terada; Kazuki Sato; Katsushi Miura; Hirokazu Arakawa; Masafumi Zaitsu; Tastuo Sakamoto; Tetsuya Takamasu; Naoki Shimojo; Makoto Kameda; Hiroyuki Mochizuki; Hiroshi Tachimoto; Koichi Yamaguchi; Kei Masuda; Yuichi Adachi; Yusei Oshima; Shigemi Yoshihara; Noriko Tanaka; Kunitaka Ohta; Masao Morita; Reiko Tokuda; Yoshihiko Kitou; Hayao Araki; Akiko Yamaoka; Akio Nakamura
      Pages: 72 - 78
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Mizuho Nagao, Masanori Ikeda, Norimasa Fukuda, Chizu Habukawa, Tetsuro Kitamura, Toshio Katsunuma, Takao Fujisawa
      Background While Japanese guideline recommends initial control treatment for preschool children with asthma symptoms more than once a month, Western guidelines do not. To determine whether control treatment with montelukast was more effective than as-needed β2-agonists in this population, we conducted a randomized controlled trial. Methods Eligible patients were children aged 1–5 years who had asthma symptoms more than once a month but less than once a week. Patients were randomly assigned in a 1:1 ratio to receive montelukast 4 mg daily for 48 weeks or as-needed β2-agonists. The primary endpoint was the number of acute asthma exacerbations before starting step-up treatment with inhaled corticosteroids. This study is registered with the University Hospital Medical Information Network clinical trials registry, number UMIN000002219. Results From September 2009 to November 2012, 93 patients (47 in the montelukast group and 46 in the no-controller group) were enrolled into the study. All patients were included in the analysis. During the study, 13 patients (28%) in the montelukast group and 23 patients (50%) in the no-controller group had acute exacerbations with the mean numbers of 0.9 and 1.9/year, respectively (P = 0.027). In addition, 10 (21%) and 19 (41%) patients received step-up treatment, respectively. Cumulative incidence of step-up treatment was significantly lower in the montelukast group (hazard ratio 0.45, 95% confidence interval 0.21 to 0.92; P = 0.033). Conclusions Montelukast is an effective control treatment for preschool children who had asthma symptoms more than once a month but less than once a week.
      Graphical abstract image

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.04.008
  • Allergic bronchopulmonary aspergillosis in Japan: A nationwide survey

    • Authors: Tsuyoshi Oguma; Masami Taniguchi; Terufumi Shimoda; Katsuhiko Kamei; Hiroto Matsuse; Akira Hebisawa; Noboru Takayanagi; Satoshi Konno; Koichi Fukunaga; Kazuki Harada; Jun Tanaka; Katsuyoshi Tomomatsu; Koichiro Asano
      Pages: 79 - 84
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Tsuyoshi Oguma, Masami Taniguchi, Terufumi Shimoda, Katsuhiko Kamei, Hiroto Matsuse, Akira Hebisawa, Noboru Takayanagi, Satoshi Konno, Koichi Fukunaga, Kazuki Harada, Jun Tanaka, Katsuyoshi Tomomatsu, Koichiro Asano
      Background Allergic bronchopulmonary aspergillosis (ABPA) is an allergic pulmonary disease characterized by a hypersensitivity reaction to Aspergillus species colonizing the airways. The clinical characteristics of ABPA may differ depending on genetic and environmental background. We performed a nationwide survey to determine the clinical characteristics of ABPA in Japan. Methods In 2013, a questionnaire on physician-diagnosed ABPA/allergic bronchopulmonary mycosis was sent to 903 medical centers specializing in respiratory or allergic diseases. Cases fulfilling the following criteria were categorized as possible ABPA-central bronchiectasis (ABPA-CB): 1) presence of specific serum immunoglobulin E (IgE) antibodies or a positive skin reaction to Aspergillus, and 2) bronchiectasis or mucoid impaction in the central bronchi. Results Of 499 physician-diagnosed cases reported by 132 clinical centers, 358 cases met the criteria for possible ABPA-CB. Median age of ABPA-CB onset was 57 (interquartile range, 44–68) years; later-onset disease, developing ≥50 years of age, accounted for 66% of the cases and was associated with female sex, delayed onset of asthma, and lower levels of serum IgE. A third of the patients (120 patients, 34%) exhibited low levels of serum total IgE (<1000 IU/mL). Aspergillus species were isolated from sputum in 126/213 cases (59%), and Schizophyllum commune was identified in 12 (6%) patients. During the course of the treatment, ABPA recurred in 169 (48%) cases. Conclusions This nationwide survey identified several unique clinical characteristics of ABPA in Japan, such as late-onset, relatively lower serum IgE levels, and frequent recurrences/flares.
      Graphical abstract image

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.04.011
  • Treatment and retreatment with omalizumab in chronic spontaneous
           urticaria: Real life experience with twenty-five patients

    • Authors: Murat Türk; İnsu Yılmaz; Sakine Nazik Bahçecioğlu
      Pages: 85 - 89
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Murat Türk, İnsu Yılmaz, Sakine Nazik Bahçecioğlu
      Background Previous data have shown the high efficacy of omalizumab in chronic spontaneous urticaria (CSU). However, factors that may be effective on the response to therapy, relapse rates after drug discontinuation, and efficacy of retreatment remain unclear. This study aimed to determine the efficacy of omalizumab in CSU refractory to conventional therapy, to identify possible factors affecting treatment response and relapse, and also to evaluate the efficacy of retreatment on relapsed disease. Methods The data of CSU patients treated with 300 mg/month omalizumab for at least 3 months were retrospectively analyzed. In order to evaluate the efficacy of treatment and retreatment, baseline and follow-up concomitant medication score (CMS) and urticaria activity score (UAS) were calculated. Possible factors affecting treatment response and relapse were identified. Results Twenty-five patients were included. The median duration of omalizumab therapy was 6 (6–12) months. Of the patients with baseline UAS 6 (5.5–6) and CMS 13 (10–15), 8 (32%) had complete response (UAS = 0) and 2 (8%) were non-responders after 3 months of therapy. None of the complete responders were positive for IgG-anti-TPO. After discontinuation of omalizumab therapy, 11 (61%) patients experienced relapse and 10 of them received retreatment with omalizumab. Half of the patients had complete response, and half had partial response (UAS = 1–4) after retreatment. No treatment related adverse events were documented. Conclusions Omalizumab has high efficacy in both the treatment and retreatment of CSU; however, relapse rates after discontinuation are high. Autoimmune markers may be helpful in predicting treatment response and relapse.

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.05.003
  • The thymus and activation-regulated chemokine (TARC) level in serum at an
           early stage of a drug eruption is a prognostic biomarker of severity of
           systemic inflammation

    • Authors: Takayoshi Komatsu-Fujii; Yuko Chinuki; Hiroyuki Niihara; Kenji Hayashida; Masataka Ohta; Ryota Okazaki; Sakae Kaneko; Eishin Morita
      Pages: 90 - 95
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Takayoshi Komatsu-Fujii, Yuko Chinuki, Hiroyuki Niihara, Kenji Hayashida, Masataka Ohta, Ryota Okazaki, Sakae Kaneko, Eishin Morita
      Background In severe drug eruptions, precise evaluation of disease severity at an early stage is needed to start appropriate treatment. It is not always easy to diagnose these conditions at their early stage. In addition, there are no reported prognostic biomarkers of disease severity in drug eruptions. The aim of this study was to test whether the thymus and activation-regulated chemokine (TARC) level in serum at an early stage of a drug eruption can serve as a prognostic biomarker of systemic inflammation. Methods Study participants included 76 patients who received a diagnosis of a drug eruption, one of the following: drug rash with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome, maculopapular exanthema, and erythema multiforme. Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) was eliminated in this study because scoring system for evaluating the severity was established. Correlation coefficients between serum TARC levels and indicators of systemic inflammation, including the neutrophil-to-lymphocyte ratio, Glasgow prognostic score, modified systemic inflammatory response syndrome (mSIRS) score, and C-reactive protein in serum were evaluated. Results Serum TARC levels positively correlated with the neutrophil-to-lymphocyte ratio, Glasgow prognostic score, mSIRS score, C-reactive protein, albumin, white blood cell count, body temperature, and pulse rate. TARC levels negatively correlated with systolic blood pressure. Among these parameters, the mSIRS score showed strong correlation (correlation coefficient: 0.68). Conclusions Serum TARC levels correlate well with indicators of systemic inflammation and of disease severity among patients with a drug eruption except SJS/TEN. Serum TARC may be a prognostic biomarker of severity of inflammation in drug eruptions.

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.06.001
  • Different clinical features of anaphylaxis according to cause and risk
           factors for severe reactions

    • Authors: Sang-Yoon Kim; Min-Hye Kim; Young-Joo Cho
      Pages: 96 - 102
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Sang-Yoon Kim, Min-Hye Kim, Young-Joo Cho
      Background Anaphylaxis is a life-threatening allergic reaction. Several studies reported different anaphylactic reactions according to the causative substances. However, a comparison of anaphylaxis for each cause has not been done. This study was conducted to identify common causes of anaphylaxis, characteristics of anaphylactic reaction for each cause and to analyze the factors related to the severity of the reaction. Methods Medical records of patients who visited the emergency room of Ewha Womans University Mokdong Hospital from March 2003 to April 2016 and diagnosed with anaphylactic shock were retrospectively reviewed. We compared the clinical features of anaphylaxis according to the cause. In addition, the severity of anaphylaxis was analyzed and contributing factors for severe anaphylaxis were reviewed. Results A total of 199 patients with anaphylaxis were analyzed. Food was the most common cause (49.7%), followed by drug reaction (36.2%), bee venom (10.1%), and unknown cause (4.0%). Cardiovascular symptoms of syncope and hypotension were more common in drug-induced anaphylaxis. The incidence of severe anaphylaxis was the highest in anaphylaxis due to drugs (54.2%). Urticaria and other skin symptoms were significantly more common in food-induced anaphylaxis. Risk factors for severe anaphylaxis included older age, male, and drug-induced one. Epinephrine treatment of anaphylaxis was done for 69.7% and 56.9% of patients with food-induced and drug-induced anaphylaxis, respectively. Conclusions More severe anaphylaxis developed with drug treatment and in males. Low rate of epinephrine prescription was also observed. Male patients with drug induced anaphylaxis should be paid more attention.

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.05.005
  • Different hypersensitivities against homologous proteins of MGL_1304 in
           patients with atopic dermatitis

    • Authors: Takuma Kohsaka; Takaaki Hiragun; Kaori Ishii; Makiko Hiragun; Akiko Kamegashira; Michihiro Hide
      Pages: 103 - 108
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Takuma Kohsaka, Takaaki Hiragun, Kaori Ishii, Makiko Hiragun, Akiko Kamegashira, Michihiro Hide
      Background Atopic dermatitis (AD) is exacerbated by sweating, and the skin of most patients with AD are resided by Malassezia (M.) fungi. Recently, MGL_1304 produced by Malassezia globosa was identified as the major histamine releasing antigen in human sweat. Methods The full length cDNA of the counterpart of MGL_1304 in Malassezia restricta (Mala r 8), was cloned by degenerate PCR and rapid identification of cDNA ends (RACE). Recombinant MGL_1304, and its counterparts, Mala s 8 (produced by Malassezia sympodialis) and Mala r 8 were prepared, and compared in their allergenicities by dot blot analysis and histamine release tests with sera and basophils of patients with AD. Results The identities between MGL_1304 and Mala s 8, MGL_1304 and Mala r 8, and Mala s 8 and Mala r 8 were 68%, 78%, and 76%, respectively, in protein sequences. Dot blot analysis revealed that the level of IgE binding to Mala s 8 was higher than that of MGL_1304. However, histamine release tests revealed that MGL_1304 and Mala r 8 possessed higher activity than Mala s 8. In addition, the crude lysate of M. globosa showed higher histamine release ability than that of M. sympodialis. Conclusions Patients with AD showed hypersensitivities against MGL_1304 and its homologs. However, the allergenicities of the homologs are variable and the histamine release activities may be different from the solid-phase binding activities for IgE. Sweat allergy should be carefully evaluated with biological activities of MGL_1304 and its homologs of other Malassezia fungi residing on the skin.

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.05.009
  • IL-17A gene polymorphism rs2275913 is associated with the development of
           asthma after bronchiolitis in infancy

    • Authors: Annukka Holster; Johanna Teräsjärvi; Eero Lauhkonen; Sari Törmänen; Merja Helminen; Petri Koponen; Matti Korppi; Ville Peltola; Qiushui He; Kirsi Nuolivirta
      Pages: 109 - 113
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Annukka Holster, Johanna Teräsjärvi, Eero Lauhkonen, Sari Törmänen, Merja Helminen, Petri Koponen, Matti Korppi, Ville Peltola, Qiushui He, Kirsi Nuolivirta
      Background Interleukin-17 (IL-17A) is a mainly pro-inflammatory cytokine, and IL-17 signaling implicates in the development of allergic asthma. The polymorphism rs2275913 in the promoter region of the IL-17A gene has in previous studies been associated with asthma susceptibility. The objective was to evaluate the association between IL-17A rs2275913 (-197G>A) polymorphism and post-bronchiolitis asthma and/or allergic rhinitis in a prospective 11–13 years post-bronchiolitis follow-up. Methods 166 previously healthy full-term infants, hospitalized for bronchiolitis at age less than 6 months, were invited to follow-up visits at the ages of 5–7 years and 11–13 years. Asthma diagnoses and presumptive symptoms, allergic rhinitis and use of inhaled corticosteroids (ICS) were registered. Blood samples for IL-17A rs2275913 (-197G>A) polymorphism were obtained during hospitalization or at the 5–7 years control visit. Results There were no significant differences between children with the wild GG and variant GA or AA genotype in the severity of bronchiolitis during hospitalization or in the outcomes until the age 5–7 years. At 11–13 years of age, children with the variant GA or AA genotype had significantly less often current asthma, use of ICSs during last 12 months or allergic rhinitis than those with the wild GG genotype. The ICS use during last 12 months retained the statistical significance in adjusted analyses (adjusted OR 0.25), whereas current asthma and allergic rhinitis marginally lost it. Conclusions The IL-17A rs2275913 (-197G>A) polymorphism decreased the risk of post-bronchiolitis asthma at 11–13 years of age, but not earlier in life, in the present prospective, long-term follow-up study.

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.05.010
  • Histopathological and clinical evaluation of chronic spontaneous urticaria
           patients with neutrophilic and non-neutrophilic cutaneous infiltrate

    • Authors: Cíntia Freitas Martins; Karina Lopes Morais; Pamela Figueroa; Natasha Favoretto Dias; Neusa Sakai Valente; Celina Wakisaba Maruta; Paulo Ricardo Criado
      Pages: 114 - 118
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Cíntia Freitas Martins, Karina Lopes Morais, Pamela Figueroa, Natasha Favoretto Dias, Neusa Sakai Valente, Celina Wakisaba Maruta, Paulo Ricardo Criado
      Background Chronic urticaria has an expressive prevalence in general population, especially in adults, and is defined by the presence of intermittent hives for six weeks or longer. Our study aims to characterize the histological patterns of chronic spontaneous urticaria, based on the inflammatory cell infiltrate, and correlate them to laboratory exams. Methods It was performed a retrospective analysis of laboratory, histopathology and direct immunofluorescence data of 93 patients with chronic urticaria. For histopathological analysis, cell count was performed in four fields at high magnification (×400) for each specimen. The resulting cell count medians were submitted to statistical analysis and, then, were correlated to laboratorial findings. Results We found a female predominance (76.34%) of chronic urticaria cases, and an average age of 42.5 years (SD ± 15). Two histological groups were distinctive: 1) chronic urticaria with predominance of neutrophils or eosinophils – N (%) = 39 (42.4%) – and 2) chronic urticaria with predominance of lymphocytes – N (%) = 53 (57.6%). There was not significant correlation between histological groups and laboratorial tests. Moreover, direct immunofluorescence was positive in 21 (33,87%) from 62 patients. Conclusions There is not enough scientific evidence to support neutrophilic urticaria as a solid, separate entity.

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.06.012
  • Efficacy of oral immunotherapy with a rice-based edible vaccine containing
           hypoallergenic Japanese cedar pollen allergens for treatment of
           established allergic conjunctivitis in mice

    • Authors: Ken Fukuda; Waka Ishida; Yosuke Harada; Yuhya Wakasa; Hidenori Takagi; Fumio Takaiwa; Atsuki Fukushima
      Pages: 119 - 123
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Ken Fukuda, Waka Ishida, Yosuke Harada, Yuhya Wakasa, Hidenori Takagi, Fumio Takaiwa, Atsuki Fukushima
      Background We have previously shown that prophylactic oral administration of transgenic rice seeds expressing hypoallergenic modified antigens suppressed the development of allergic conjunctivitis induced by Japanese cedar pollen. We have now investigated the efficacy of oral immunotherapy with such transgenic rice for established allergic conjunctivitis in mice. Methods BALB/c mice were sensitized with two intraperitoneal injections of Japanese cedar pollen in alum, challenged with pollen in eyedrops, and then fed for 16 days with transgenic rice seeds expressing modified Japanese cedar pollen allergens Cry j 1 and Cry j 2 or with nontransgenic rice seeds as a control. They were then challenged twice with pollen in eyedrops, with clinical signs being evaluated at 15 min after the first challenge and the eyes, blood, spleen, and lymph nodes being isolated at 24 h after the second challenge. Results The number of eosinophils in the conjunctiva and the clinical score for conjunctivitis were both significantly lower in mice fed the transgenic rice than in those fed nontransgenic rice. Oral vaccination with transgenic rice seeds also resulted in a significant increase in the production of IFN-γ by splenocytes, whereas it had no effect on the number of CD4+CD25+Foxp3+ regulatory T cells in the spleen or submandibular or mesenteric lymph nodes. Conclusions Oral administration of transgenic rice seeds expressing hypoallergenic allergens ameliorated allergic conjunctivitis in the established setting. Such a rice-based edible vaccine is potentially both safe and effective for oral immunotherapy in individuals with allergic conjunctivitis.
      Graphical abstract image

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.06.006
  • Serum levels of squamous cell carcinoma antigens 1 and 2 reflect disease
           severity and clinical type of atopic dermatitis in adult patients

    • Authors: Tomoko Okawa; Yukie Yamaguchi; Kenzen Kou; Junya Ono; Yoshinori Azuma; Noriko Komitsu; Yusuke Inoue; Masumi Kohno; Setsuko Matsukura; Takeshi Kambara; Shoichiro Ohta; Kenji Izuhara; Michiko Aihara
      Pages: 124 - 130
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Tomoko Okawa, Yukie Yamaguchi, Kenzen Kou, Junya Ono, Yoshinori Azuma, Noriko Komitsu, Yusuke Inoue, Masumi Kohno, Setsuko Matsukura, Takeshi Kambara, Shoichiro Ohta, Kenji Izuhara, Michiko Aihara
      Background Recent studies have indicated that serum levels of squamous cell carcinoma antigen (SCCA) 1 and 2 induced by type 2 cytokines such as IL-4 and IL-13, are increased in patients with atopic dermatitis (AD). However, no clinical studies have analyzed serum levels of SCCA2 in larger series of AD patients or their association with various clinical characteristics. This study was performed to clarify whether serum levels of SCCA2 are associated with disease severity and clinical phenotypes of adult AD patients. Methods An enzyme-linked immunosorbent assay was performed to examine serum SCCA2 levels in 240 adult patients with AD and 25 healthy controls in this study. Serum SCCA2 levels were analyzed with clinical characteristics and laboratory parameters including thymus and activation-regulated chemokine (TARC), lactate dehydrogenase (LDH), blood eosinophils, total IgE, and specific IgE (Japanese cedar pollen, Dermatophagoides farina, Candida, malassezia, Staphylococcal enterotoxin B). Expression of SCCA2 in AD eruption was examined by immunohistochemistry. The effect of treatment on serum SCCA2 was also assessed. Results Serum SCCA2 level showed a positive correlation with disease severity, levels of TARC, LDH, eosinophil counts, and IgE levels. Robust expression of SCCA2 was detected in the supra basal keratinocytes in the epidermis of AD patients. Serial measurements of serum SCCA2 revealed decreased levels of SCCA2 after treatment for AD. Conclusions Serum SCCA2 levels reflected disease severity and clinical type of AD. Serum SCCA2 may thus be a relevant biomarker for AD.

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.06.016
  • Development of a questionnaire to evaluate asthma control in Japanese
           asthma patients

    • Authors: Yuji Tohda; Soichiro Hozawa; Hiroshi Tanaka
      Pages: 131 - 137
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Yuji Tohda, Soichiro Hozawa, Hiroshi Tanaka
      Background The asthma control questionnaires used in Japan are Japanese translations of those developed outside Japan, and have some limitations; a questionnaire designed to optimally evaluate asthma control levels for Japanese may be necessary. The present study was conducted to validate the Japan Asthma Control Survey (JACS) questionnaire in Japanese asthma patients. Methods A total of 226 adult patients with mild to severe persistent asthma were enrolled and responded to the JACS questionnaire, asthma control questionnaire (ACQ), and Mini asthma quality of life questionnaire (Mini AQLQ) at Weeks 0 and 4. The reliability, validity, and sensitivity/responsiveness of the JACS questionnaire were evaluated. Results The intra-class correlation coefficients (ICCs) were within the range of 0.55–0.75 for all JACS scores, indicating moderate/substantial reproducibility. For internal consistency, Cronbach's alpha coefficients ranged from 0.76 to 0.92 in total and subscale scores, which were greater than the lower limit of internal consistency. As for factor validity, the cumulative contribution ratio of four main factors was 0.66. For criterion-related validity, the correlation coefficients between the JACS total score and ACQ5, ACQ6, and Mini AQLQ scores were −0.78, −0.78, and 0.77, respectively, showing a significant correlation (p < 0.0001). Conclusions The JACS questionnaire was validated in terms of reliability and validity. It will be necessary to evaluate the therapeutic efficacy measured by the JACS questionnaire and calculate cutoff values for the asthma control status in a higher number of patients. Clinical Trial registration UMIN000016589

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.06.013
  • A case of eel collagen allergy

    • Authors: Masao Tamura; Kiyoshi Matsui; Yukihiro Kobayashi; Chie Ogita; Kazuyuki Tsuboi; Minori Kusakabe; Kota Azuma; Takeo Abe; Takahiro Yoshikawa; Masahiro Sekiguchi; Naoto Azuma; Masayasu Kitano; Hajime Sano
      Pages: 138 - 140
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Masao Tamura, Kiyoshi Matsui, Yukihiro Kobayashi, Chie Ogita, Kazuyuki Tsuboi, Minori Kusakabe, Kota Azuma, Takeo Abe, Takahiro Yoshikawa, Masahiro Sekiguchi, Naoto Azuma, Masayasu Kitano, Hajime Sano

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.04.012
  • Identification of a novel food allergen in lotus root

    • Authors: Yukiko Hiraguchi; Reiko Tokuda; Mari Gen; Tomoya Shingaki; Shoko Yoshino; Yusuke Kumagai; Yuko Ebishima; Junya Hirayama; Keigo Kainuma; Mizuho Nagao; Kenji Owa; Yutaka Suehiro; Takao Fujisawa
      Pages: 141 - 143
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Yukiko Hiraguchi, Reiko Tokuda, Mari Gen, Tomoya Shingaki, Shoko Yoshino, Yusuke Kumagai, Yuko Ebishima, Junya Hirayama, Keigo Kainuma, Mizuho Nagao, Kenji Owa, Yutaka Suehiro, Takao Fujisawa

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.05.006
  • Successful long-term prophylaxis with human plasma-derived C1 inhibitor in
           planning and carrying out pregnancy

    • Authors: Susana Calaforra-Méndez; Ethel Ibáñez Echevarría; Carolina Perales Chordá; María Verónica Pacheco-Coronel; Agustín Fernández Llópez; Dolores Hernández Fernández de Rojas
      Pages: 144 - 146
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Susana Calaforra-Méndez, Ethel Ibáñez Echevarría, Carolina Perales Chordá, María Verónica Pacheco-Coronel, Agustín Fernández Llópez, Dolores Hernández Fernández de Rojas

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.05.008
  • Obesity-related systemic oxidative stress: An important factor of poor
           asthma control

    • Authors: Masako To; Yuta Kono; Naoto Ogura; Shintaro Mikami; Natsue Honda; Akihiro Hitani; Ichino Kano; Kosuke Haruki; Yasuo To
      Pages: 147 - 149
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Masako To, Yuta Kono, Naoto Ogura, Shintaro Mikami, Natsue Honda, Akihiro Hitani, Ichino Kano, Kosuke Haruki, Yasuo To

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.06.002
  • A lung sound analysis in a child thought to have cough variant asthma: A
           case report

    • Authors: Eri Imai; Mayumi Enseki; Mariko Nukaga; Hideyuki Tabata; Kota Hirai; Masahiko Kato; Hiroyuki Mochizuki
      Pages: 150 - 152
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Eri Imai, Mayumi Enseki, Mariko Nukaga, Hideyuki Tabata, Kota Hirai, Masahiko Kato, Hiroyuki Mochizuki

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.06.004
  • Survey on the proper use of an adrenaline auto-injector in 551 Japanese
           outdoor workers after Hymenoptera stings

    • Authors: Hirokuni Hirata; Naruo Yoshida; Masamitsu Tatewaki; Sadaaki Shiromori; Kozo Sato; Tomoshige Wakayama; Shingo Tokita; Kumiya Sugiyama; Masafumi Arima; Kazuhiro Kurasawa; Takeshi Fukuda; Daisuke Shima; Yasutsugu Fukushima
      Pages: 153 - 155
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Hirokuni Hirata, Naruo Yoshida, Masamitsu Tatewaki, Sadaaki Shiromori, Kozo Sato, Tomoshige Wakayama, Shingo Tokita, Kumiya Sugiyama, Masafumi Arima, Kazuhiro Kurasawa, Takeshi Fukuda, Daisuke Shima, Yasutsugu Fukushima

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.06.009
  • Occupational allergy to Triticum spelta flour

    • Authors: Gemma Mencia; David El-Qutob; Fernando Pineda; Miriam Castillo
      Pages: 158 - 159
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Gemma Mencia, David El-Qutob, Fernando Pineda, Miriam Castillo

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.07.004
  • Immediate-type allergic reactions to local anesthetics

    • Authors: Naomi Nakamura; Risa Tamagawa-Mineoka; Koji Masuda; Norito Katoh
      Pages: 160 - 161
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Naomi Nakamura, Risa Tamagawa-Mineoka, Koji Masuda, Norito Katoh

      PubDate: 2018-01-03T10:08:55Z
      DOI: 10.1016/j.alit.2017.07.003
  • The optimal age for epicutaneous sensitization following tape-stripping in
           BALB/c mice

    • Authors: Masato Tamari; Keisuke Orimo; Kenichiro Motomura; Ken Arae; Susumu Nakae; Akio Matsuda; Hideaki Morita; Hirohisa Saito; Kenji Matsumoto
      Abstract: Publication date: Available online 10 February 2018
      Source:Allergology International
      Author(s): Masato Tamari, Keisuke Orimo, Kenichiro Motomura, Ken Arae, Akio Matsuda, Susumu Nakae, Hirohisa Saito, Hideaki Morita, Kenji Matsumoto
      Background Direct contact of food proteins with eczematous lesions is thought to be the main cause of epicutaneous sensitization. To further investigate the development and pathogenesis of food allergy in vivo, a good mouse model of epicutaneous sensitization is needed. However, a fundamental problem in that regard is that the optimal age for epicutaneous sensitization of mice is unknown. In this study, we attempted to elucidate that optimal age. Methods Dorsal skin of wild-type BALB/c female mice (1, 3, 8 and 24 weeks old) was shaved, depilated and tape-stripped. A Finn chamber containing a 20-μl-aliquot of 20-mg/ml (OVA) was applied to the tape-stripped skin on 3 consecutive days/week, for 3 weeks. The body temperature was measured after intraperitoneal OVA challenge. Serum OVA-specific IgE titers and OVA-induced cytokine production by spleen cells were measured by ELISA. Dendritic cells (DCs) that migrated to the draining lymph nodes were quantified by FITC-labeled OVA and flow cytometry. The mRNA expression levels in the dorsal skin were measured by qPCR. Results A significant age-dependent body temperature decline was observed after OVA challenge. The serum OVA-specific IgE titer, OVA-induced cytokine production (i.e., IL-4, IL-5 and IL-13) by spleen cells, and number of FITC-OVA-engulfing DCs increased with age. In addition, mRNA for IL-33, but not TSLP or IL-25, was significantly induced in the skin by tape-stripping and increased with age. Conclusions Twenty-four-week-old mice showed the greatest DC migration, Th2 polarization, IgE production and body temperature decline. Skin-derived IL-33 is likely to play key roles in those changes.

      PubDate: 2018-02-13T10:09:03Z
      DOI: 10.1016/j.jaci.2017.12.469
  • Definition and diagnosis of asthma–COPD overlap (ACO)

    • Authors: Satoru Yanagisawa; Masakazu Ichinose
      Abstract: Publication date: Available online 9 February 2018
      Source:Allergology International
      Author(s): Satoru Yanagisawa, Masakazu Ichinose
      It is now widely recognized that asthma and COPD can coexist as asthma–COPD overlap (ACO), but the preliminary attempts at providing universal guidelines for the diagnosis of ACO still need to be improved. We believe that a case can be made for devising guidelines for the diagnosis of this increasingly common disease that are specific to Japan. In this paper, we present our consensus-based description of ACO which we believe is realistic for use in our country. In addition, we cite the scientific evidence for our own “objective” features used to develop the criteria for COPD and asthma diagnosis. We acknowledge that they will need to be validated and updated over time, but hope the results will encourage further research on the characteristics and treatment of this commonly encountered clinical problem.

      PubDate: 2018-02-13T10:09:03Z
      DOI: 10.1016/j.alit.2018.01.002
  • A case of contact dermatitis and contact urticaria syndrome due to
           multiple allergens observed in a professional baseball player

    • Authors: Kaoru Nishiwaki; Yuka Matsumoto; Kosuke Kishida; Muneaki Kaku; Ryoji Tsuboi; Yukari Okubo
      Abstract: Publication date: Available online 1 February 2018
      Source:Allergology International
      Author(s): Kaoru Nishiwaki, Yuka Matsumoto, Kosuke Kishida, Muneaki Kaku, Ryoji Tsuboi, Yukari Okubo

      PubDate: 2018-02-13T10:09:03Z
      DOI: 10.1016/j.alit.2017.12.003
  • Aquagenic urticaria: Severe extra-cutaneous symptoms following cold water

    • Authors: Takeshi Fukumoto; Kanako Ogura; Atsushi Fukunaga; Chikako Nishigori
      Abstract: Publication date: Available online 9 January 2018
      Source:Allergology International
      Author(s): Takeshi Fukumoto, Kanako Ogura, Atsushi Fukunaga, Chikako Nishigori

      PubDate: 2018-01-10T10:38:05Z
      DOI: 10.1016/j.alit.2017.10.007
  • “Spike” in acute asthma exacerbations during enterovirus D68 epidemic
           in Japan: A nation-wide survey

    • Authors: Seigo Korematsu; Kengo Nagashima Yasunori Sato Mizuho Nagao Shunji Hasegawa
      Abstract: Publication date: January 2018
      Source:Allergology International, Volume 67, Issue 1
      Author(s): Seigo Korematsu, Kengo Nagashima, Yasunori Sato, Mizuho Nagao, Shunji Hasegawa, Haruna Nakamura, Shiro Sugiura, Katsushi Miura, Kenji Okada, Takao Fujisawa
      Background In September 2015, Japan experienced an unusual increase in acute asthma hospitalizations of children that coincided with an enterovirus D68 (EV-D68) epidemic. The objective of this study is to investigate whether EV-D68 had a causal relationship with the spike in asthma hospitalizations. Methods A nation-wide retrospective survey of asthma hospitalizations of children was performed for the period from January 2010 through October 2015. The Japanese Society of Pediatric Allergy and Clinical Immunology asked its affiliated hospitals to report monthly numbers of hospitalizations, ICU admissions and mechanical ventilations due to acute asthma exacerbation. The data were retrieved from medical databases using predefined search criteria: diagnosis of asthma or asthmatic bronchitis, admission, and age <20 years. Monthly numbers of EV-D68 detection were also obtained from the Infectious Disease Surveillance Center of Japan. A Granger causality test was used to analyze the association of EV-D68 detections for asthma exacerbation. Results A total of 157 hospitals reported 87,189 asthma hospitalizations, including 477 ICU admissions and 1193 mechanical ventilations, during the survey period of 5 years and 10 months. The numbers of these events increased drastically in September 2015. The Granger causality test verified the association between EV-D68 and asthma hospitalizations/mechanical ventilations. The most-affected age group was 3–6 years old. Conclusions The spike in pediatric asthma hospitalizations in Japan in September 2015 was found to be associated with the EV-D68 epidemic. Respiratory pathogens can cause “epidemics” of asthma exacerbation. Coordinated surveillance of infectious diseases and asthma may be beneficial for prevention and better control of both illnesses.
      Graphical abstract image

      PubDate: 2018-01-03T10:08:55Z
  • Old friends, microbes, and allergic diseases

    • Authors: Naoki Shimojo; Kenji Izuhara
      Pages: 513 - 514
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Naoki Shimojo, Kenji Izuhara

      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.08.009
  • Increased ratio of pollock roe-specific IgE to salmon roe-specific IgE
           levels is associated with a positive reaction to cooked pollock roe oral
           food challenge

    • Authors: Eishi Makita; Noriyuki Yanagida; Sakura Sato; Tomoyuki Asaumi; Motohiro Ebisawa
      Abstract: Publication date: Available online 11 December 2017
      Source:Allergology International
      Author(s): Eishi Makita, Noriyuki Yanagida, Sakura Sato, Tomoyuki Asaumi, Motohiro Ebisawa
      Background Anaphylaxis and immediate-type fish roe allergies have been reported worldwide, and, in Japan, fish roe is the sixth most common food allergen. No oral food challenges (OFCs) have used pollock roe (PR), which is reported to have high cross-reactivity with salmon roe (SR). Therefore, we administered an OFC using cooked PR to evaluate PR- and SR-specific immunoglobulin E (IgE) levels and allergic reactions in patients with PR sensitivity. Methods This retrospective study evaluating patient characteristics and responses to OFCs was conducted with 10–20 g of cooked PR, between April 2006 and November 2016. Results We assessed 51 patients (median age: 6.8 years). All had PR sensitization, 6 (12%) with a history of immediate reactions to PR, and 18 (35%) of immediate reactions to SR. Median PR-specific and SR-specific IgE values were 3.4 kUA/L and 9.9 kUA/L, respectively. Seven patients (14%) had a positive OFC. There was no anaphylaxis. Induced symptoms were mild and included localized urticaria, throat pruritus, intermittent cough, and mild abdominal pain. We treated one patient with mild abdominal pain with oral antihistamines. There were no significant differences in history of immediate reaction to PR and PR-specific IgE titers between OFC-positive and OFC-negative patients, although significant differences were found for PR-specific IgE titers adjusted for SR-specific IgE (p = 0.025) and PR-specific IgE/SR-specific IgE ratio (p = 0.009). Conclusions Increased PR-specific IgE/SR-specific IgE ratio or PR-specific IgE levels adjusted for SR-specific IgE levels were risk factors for OFC positivity.

      PubDate: 2017-12-18T07:54:57Z
      DOI: 10.1016/j.alit.2017.11.005
  • ETosis-derived DNA trap production in middle ear effusion is a common
           feature of eosinophilic otitis media

    • Authors: Nobuo Ohta; Shigeharu Ueki; Yasunori Konno; Makoto Hirokawa; Toshinori Kubota; Sachiko Tomioka-Matsutani; Takahiro Suzuki; Yusuke Ishida; Tasuku Kawano; Tomomitsu Miyasaka; Tomoko Takahashi; Tatsutoshi Suzuki; Isao Ohno; Seiji Kakehata; Shigeharu Fujieda
      Abstract: Publication date: Available online 11 December 2017
      Source:Allergology International
      Author(s): Nobuo Ohta, Shigeharu Ueki, Yasunori Konno, Makoto Hirokawa, Toshinori Kubota, Sachiko Tomioka-Matsutani, Takahiro Suzuki, Yusuke Ishida, Tasuku Kawano, Tomomitsu Miyasaka, Tomoko Takahashi, Tatsutoshi Suzuki, Isao Ohno, Seiji Kakehata, Shigeharu Fujieda

      PubDate: 2017-12-18T07:54:57Z
      DOI: 10.1016/j.alit.2017.11.007
  • Recent advances in understanding the roles of blood platelets in the
           pathogenesis of allergic inflammation and bronchial asthma

    • Authors: Tomohiro Takeda; Hideaki Morita; Hirohisa Saito; Kenji Matsumoto; Akio Matsuda
      Abstract: Publication date: Available online 11 December 2017
      Source:Allergology International
      Author(s): Tomohiro Takeda, Hideaki Morita, Hirohisa Saito, Kenji Matsumoto, Akio Matsuda
      Platelets play an essential role in hemostasis to minimize blood loss due to traumatic injury. In addition, they contain various immune-associated molecules and contribute to immunological barrier formation at sites of vascular injury, thereby protecting against invading pathogens. Platelets are also crucially involved in development of allergic diseases, including bronchial asthma. Platelets in asthmatics are more activated than those in healthy individuals. By using a murine asthma model, platelets were shown to be actively involved in progression of the disease, including in airway eosinophilia and airway remodeling. In the asthmatic airway, pathological microvascular angiogenesis, a component of airway remodeling, is commonly observed, and the degree of abnormality is significantly associated with disease severity. Therefore, in order to repair the newly formed and structurally fragile blood vessels under inflammatory conditions, platelets may be continuously activated in asthmatics. Importantly, platelets constitutively express IL-33 protein, an alarmin cytokine that is essential for development of bronchial asthma. Meanwhile, the concept of development of allergic diseases has recently changed dramatically, and allergy researchers now share a belief in the centrality of epithelial barrier functions. In particular, IL-33 released from epithelial barrier tissue at sites of eczema can activate the antigen-non-specific innate immune system as an alarmin that is believed to be necessary for subsequent antigen-specific acquired immunological responses. From this perspective, we propose in this review a possible mechanism for how activated platelets act as an alarmin in development of bronchial asthma.

      PubDate: 2017-12-18T07:54:57Z
      DOI: 10.1016/j.alit.2017.11.008
  • Long-term safety of subcutaneous immunotherapy with TO-204 in Japanese
           patients with house dust mite-induced allergic rhinitis and allergic
           bronchial asthma: Multicenter, open label clinical trial

    • Authors: Takao Fujisawa; Terufumi Shimoda; Keisuke Masuyama; Kimihiro Okubo; Kohei Honda; Mitsuhiro Okano; Toshio Katsunuma; Atsuo Urisu; Yasuto Kondo; Hiroshi Odajima; Kazuyuki Kurihara; Makoto Nagata; Masami Taniguchi; Shoichiro Taniuchi; Satoru Doi; Tomoshige Matsumoto; Shoji Hashimoto; Akihiko Tanaka; Kensuke Natsui; Nahoko Abe; Hideki Ozaki
      Abstract: Publication date: Available online 7 December 2017
      Source:Allergology International
      Author(s): Takao Fujisawa, Terufumi Shimoda, Keisuke Masuyama, Kimihiro Okubo, Kohei Honda, Mitsuhiro Okano, Toshio Katsunuma, Atsuo Urisu, Yasuto Kondo, Hiroshi Odajima, Kazuyuki Kurihara, Makoto Nagata, Masami Taniguchi, Shoichiro Taniuchi, Satoru Doi, Tomoshige Matsumoto, Shoji Hashimoto, Akihiko Tanaka, Kensuke Natsui, Nahoko Abe, Hideki Ozaki
      Background To evaluate the long-term safety of subcutaneous immunotherapy with TO-204, a standardized house dust mite (HDM) allergen extracts, we conducted a multicenter, open label clinical trial. Methods Japanese patients aged 5–65 years were eligible for the study, if they had HDM-induced allergic rhinitis (AR), allergic bronchial asthma (BA), or both. TO-204 was administered in a dose titration scheme, and the maintenance dose was determined according to the predefined criteria. The treatment period was 52 weeks, and patients who were willing to continue the treatment received TO-204 beyond 52 weeks. This clinical trial is registered at the Japan Pharmaceutical Information Center (Japic CTI-121900). Results Between July 2012 and May 2015, 44 patients (28 with AR and 16 with allergic BA) were enrolled into the study. All patients were included in the analysis. The duration of treatment ranged from 23 to 142 weeks and the median maintenance dose was 200 Japanese allergy units (JAU). Adverse events occurred in 22 patients (50%). The most common adverse event was local reactions related to the injection sites. Four patients experienced anaphylactic reactions when they were treated with the dose of 500 JAU. Two patients experienced anaphylactic shock with the doses of 1000 JAU at onset. These 6 patients could continue the study with dose reduction. Conclusions Safety profile of TO-204 was acceptable in Japanese patients with HDM-induced AR or allergic BA. Higher doses should be administered carefully, because the risk of anaphylaxis increased at doses of 500 or 1000 JAU.

      PubDate: 2017-12-08T17:51:31Z
      DOI: 10.1016/j.alit.2017.11.004
  • Serum periostin is associated with body mass index and allergic rhinitis
           in healthy and asthmatic subjects

    • Authors: Hirokazu Kimura; Satoshi Konno; Hironi Makita; Natsuko Taniguchi; Hiroki Kimura; Houman Goudarzi; Kaoruko Shimizu; Masaru Suzuki; Noriharu Shijubo; Katsunori Shigehara; Junya Ono; Kenji Izuhara; Yoichi Minagawa Ito; Masaharu Nishimura
      Abstract: Publication date: Available online 7 December 2017
      Source:Allergology International
      Author(s): Hirokazu Kimura, Satoshi Konno, Hironi Makita, Natsuko Taniguchi, Hiroki Kimura, Houman Goudarzi, Kaoruko Shimizu, Masaru Suzuki, Noriharu Shijubo, Katsunori Shigehara, Junya Ono, Kenji Izuhara, Yoichi Minagawa Ito, Masaharu Nishimura
      Background Many studies have attempted to clarify the factors associated with serum periostin levels in asthmatic patients. However, these results were based on studies of subjects mainly characterized by high eosinophil counts, which may present as an obstacle for clarification in the identification of other factors associated with serum periostin levels. The aim of this study was to determine the factors associated with serum periostin levels in healthy subjects. We also assessed some factors in asthmatic subjects to confirm their extrapolation for management of asthma. Methods Serum periostin levels were measured in 230 healthy subjects. Clinical factors of interest included body mass index (BMI) and allergic rhinitis (AR). Additionally, we confirmed whether these factors were associated with serum periostin in 206 asthmatic subjects. We further evaluated several obesity-related parameters, such as abdominal fat distribution and adipocytokine levels. Results Smoking status, blood eosinophil count, total immunoglobulin E, and the presence of AR were associated with serum periostin in healthy subjects. There was a negative association between BMI and serum periostin in both healthy and asthmatic subjects, while there was a tendency of a positive association with AR in asthmatic subjects. There were no differential associations observed for subcutaneous and abdominal fat in relation to serum periostin in asthmatic subjects. Serum periostin was significantly associated with serum levels of adiponectin, but not with leptin. Conclusions Our results provided clarity as to the factors associated with serum periostin levels, which could be helpful in the interpretation of serum periostin levels in clinical practice.

      PubDate: 2017-12-08T17:51:31Z
      DOI: 10.1016/j.alit.2017.11.006
  • Recent advancement to prevent the development of allergy and allergic
           diseases and therapeutic strategy in the perspective of barrier

    • Authors: Osamu Natsume; Yukihiro Ohya
      Abstract: Publication date: Available online 7 December 2017
      Source:Allergology International
      Author(s): Osamu Natsume, Yukihiro Ohya
      Therapeutic strategy in late 20th century to prevent allergic diseases was derived from a conceptual framework of allergens elimination which was as same as that of coping with them after their onset. Manifold trials were implemented; however, most of them failed to verify the effectiveness of their preventive measures. Recent advancement of epidemiological studies and cutaneous biology revealed epidermal barrier dysfunction plays a major role of allergen sensitization and development of atopic dermatitis which ignites the inception of allergy march. For this decade, therapeutic strategy to prevent the development of food allergy has been confronted with a paradigm shift from avoidance and delayed introduction of allergenic foods based on the theoretical concept to early introduction of them based on the clinical and epidemiological evidences. Especially, prevention of peanut allergy and egg allergy has been established with the highest evidence verified by randomized controlled trials, although application in clinical practice should be done with attention. This paradigm shift concerning food allergy was also due to the discovery of cutaneous sensitization risk of food allergens for an infant with eczema revealed by prospective studies. Here we have recognized the increased importance of prevention of eczema/atopic dermatitis in infancy. Two randomized controlled trials using emollients showed successful results in prevention of atopic dermatitis in infancy; however, longer term safety and prognosis including allergy march should be pursued. To establish more fundamental strategy for prevention of the development of allergy, further studies clarifying the mechanisms of interaction between barrier dysfunction and microbial milieu are needed with macroscope to understand the relationship between allergic diseases and a diversity of environmental influences.

      PubDate: 2017-12-08T17:51:31Z
      DOI: 10.1016/j.alit.2017.11.003
  • Long-term immunological effects of Japanese cedar pollen-based
           subcutaneous immunotherapy

    • Authors: Chisato Inuo; Hitoshi Ando; Kenichi Tanaka; Yoichi Nakajima; Ikuya Tsuge; Atsuo Urisu; Yasuto Kondo
      Abstract: Publication date: Available online 1 December 2017
      Source:Allergology International
      Author(s): Chisato Inuo, Hitoshi Ando, Kenichi Tanaka, Yoichi Nakajima, Ikuya Tsuge, Atsuo Urisu, Yasuto Kondo

      PubDate: 2017-12-08T17:51:31Z
      DOI: 10.1016/j.alit.2017.11.002
  • Th1-related disease development during omalizumab treatment: Two cases
           with severe asthma

    • Authors: Hiroaki Hayashi; Yuma Fukutomi; Chihiro Mitsui; Kentaro Watai; Yasuhiro Tomita; Yosuke Kamide; Kiyoshi Sekiya; Takahiro Tsuburai; Ayako Horita; Ikuo Saito; Yoshinori Hasegawa; Masami Taniguchi
      Abstract: Publication date: Available online 27 November 2017
      Source:Allergology International
      Author(s): Hiroaki Hayashi, Yuma Fukutomi, Chihiro Mitsui, Kentaro Watai, Yasuhiro Tomita, Yosuke Kamide, Kiyoshi Sekiya, Takahiro Tsuburai, Ayako Horita, Ikuo Saito, Yoshinori Hasegawa, Masami Taniguchi

      PubDate: 2017-12-08T17:51:31Z
      DOI: 10.1016/j.alit.2017.10.008
  • Surfing as a risk factor for sensitization to poly(γ-glutamic acid) in
           fermented soybeans, natto, allergy

    • Authors: Naoko Inomata; Mami Miyakawa; Michiko Aihara
      Abstract: Publication date: Available online 24 November 2017
      Source:Allergology International
      Author(s): Naoko Inomata, Mami Miyakawa, Michiko Aihara
      Background Poly(γ-glutamic acid) (PGA) is an allergen in natto, fermented soybeans, which causes late-onset anaphylaxis. We hypothesized that jellyfish stings sensitize adults to PGA because a surfer had allergies to both natto and jellyfish, whose sting contains PGA. The aim of the study was to identify behavioral factors, such as marine sports, associated with PGA sensitization. Methods Outpatients diagnosed with food allergies based on relevant clinical history, positive skin test and/or food challenge test answered a questionnaire during a regular visit in 2016. Results Questionnaire data from 140 outpatients were analyzed. These patients were divided into two groups: natto allergy group (13 patients, M:F = 10:3, mean age 40.6 years) and non-natto allergy group (127 patients, M:F = 46:81, mean age 44.5 years). All patients with natto allergy had positive results in skin prick test and basophil activation test with PGA. Of these, 92.3% had a marine sport hobby, especially surfing (84.6%). PGA sensitization was independently associated with marine sports (odds ratio, 278.0, 95 percent confidence interval, 36.9–6315.9, p < 0.001) adjusted for male sex and sea bathing, but not with male sex or sea bathing. In addition, although there was no significant difference in the experience of marine sports between natto and non-natto allergy groups, the natto allergy group participated significantly more frequently in marine sports than the non-natto allergy group (p < 0.001). There was no significant difference between natto consumption amount and PGA sensitization. Conclusions Surfing is a risk factor for PGA sensitization in those with allergy to natto.

      PubDate: 2017-12-08T17:51:31Z
      DOI: 10.1016/j.alit.2017.11.001
  • Barrier dysfunction in the skin allergy

    • Authors: Gyohei Egawa; Kenji Kabashima
      Abstract: Publication date: Available online 16 November 2017
      Source:Allergology International
      Author(s): Gyohei Egawa, Kenji Kabashima
      The skin is continuously exposed to external pathogens, and its barrier function is critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one of the most predisposing factors for the development of skin allergic diseases such as atopic dermatitis. In this article, we summarize how the physical barrier of the skin is organized and review its link to the pathomechanism of skin allergic diseases. We describe the formation of the SC barrier in terms of the following five categories: 1) filaggrin metabolism; 2) cornified envelope; 3) intercellular lipids; 4) corneodesmosome; and 5) corneocyte desquamation. New approaches to restoring the skin barrier function are also discussed.

      PubDate: 2017-12-08T17:51:31Z
      DOI: 10.1016/j.alit.2017.10.002
  • Barrier dysfunction in the nasal allergy

    • Authors: Ayumi Fukuoka; Tomohiro Yoshimoto
      Abstract: Publication date: Available online 14 November 2017
      Source:Allergology International
      Author(s): Ayumi Fukuoka, Tomohiro Yoshimoto
      Epithelial cells form the first physiological barrier against invasion by pathogens and the infiltration of allergens. Tight junctions (TJ), a cell–cell junctional complex located on the apical side of epithelial cells, have a critical role in the maintenance of epithelial barrier function. Impaired TJ structures are observed in patients with asthma, atopic dermatitis and nasal allergy; therefore, the dysfunction of epithelial barriers might be involved in the initiation or progression of allergic diseases. Protease-containing allergens and environmental pollutants enhance paracellular transport in epithelial cells through disruption of epithelial barrier function. This suggests that the disruption of TJ leads to the promotion of allergen delivery into the subepithelia, resulting in the progression of allergic diseases. Thus, protection of the epithelial barrier function might prevent or inhibit the development or exacerbation of allergic diseases. Recently, we reported that diesel exhaust particles (DEP), the main component of particulate patter 2.5, exacerbated allergic rhinitis (AR) in a mouse model through TJ disruption. In addition, we revealed that the oxidative stress-mediated pathway is involved in the effects caused by DEP and that nasal treatment with a reactive oxygen species (ROS) scavenger suppressed DEP-induced TJ disruption and exacerbation of AR. In this review, we focus on the relationship between TJ disruption and allergic disease. Furthermore, we discuss our recent findings regarding TJ disruption and the exacerbation of AR.

      PubDate: 2017-11-17T06:25:22Z
      DOI: 10.1016/j.alit.2017.10.006
  • Efficacy and safety of benralizumab in Japanese patients with severe,
           uncontrolled eosinophilic asthma

    • Authors: Ken Ohta; Mitsuru Adachi; Yuji Tohda; Tadashi Kamei; Motokazu Kato; J. Mark Fitzgerald; Masayuki Takanuma; Tadahiro Kakuno; Nobuyuki Imai; Yanping Wu; Magnus Aurivillius; Mitchell Goldman
      Abstract: Publication date: Available online 8 November 2017
      Source:Allergology International
      Author(s): Ken Ohta, Mitsuru Adachi, Yuji Tohda, Tadashi Kamei, Motokazu Kato, J. Mark Fitzgerald, Masayuki Takanuma, Tadahiro Kakuno, Nobuyuki Imai, Yanping Wu, Magnus Aurivillius, Mitchell Goldman
      Background In the Phase III CALIMA trial, benralizumab significantly reduced asthma exacerbations, increased lung function, and alleviated symptoms for patients with severe, uncontrolled eosinophilic asthma. The aim of this subgroup analysis was to evaluate the efficacy and safety of benralizumab for Japanese patients in the CALIMA trial. Methods CALIMA was a randomised, controlled trial of 1306 patients (aged 12–75 years; registered at NCT01914757) with severe asthma uncontrolled by medium- to high-dosage inhaled corticosteroids and long-acting β2-agonists (ICS/LABA). Patients received 56 weeks' benralizumab 30 mg either every 4 weeks (Q4W) or every 8 weeks (Q8W; first three doses Q4W), or placebo Q4W. The primary analysis population was patients receiving high-dosage ICS/LABA with blood eosinophils ≥300 cells/μL. This subgroup analysis covered Japanese patients from this group. Results Of 83 patients randomised in Japan, 46 were receiving high-dosage ICS/LABA and had blood eosinophils ≥300 cells/μL. Compared with placebo, benralizumab reduced the annual rate of asthma exacerbations by 66% (Q4W; rate ratio 0.34, 95% CI, 0.11–0.99) and 83% (Q8W; rate ratio 0.17, 95% CI, 0.05–0.60); increased prebronchodilator FEV1 by 0.334 L (Q4W; 95% CI, 0.020–0.647) and 0.198 L (Q8W; 95% CI, −0.118 to 0.514); and decreased total asthma symptom score by 0.17 (Q4W; 95% CI, −0.82 to 0.48) and 0.24 (Q8W; 95% CI, −0.87 to 0.40). Percentages of adverse events were consistent with the overall CALIMA group. Conclusions Benralizumab reduced annual asthma exacerbations and symptoms, increased lung function, and was well-tolerated by Japanese patients with severe, uncontrolled eosinophilic asthma.

      PubDate: 2017-11-10T05:12:03Z
      DOI: 10.1016/j.alit.2017.10.004
  • Up-regulation of serum periostin and squamous cell carcinoma antigen
           levels in infants with acute bronchitis due to respiratory syncytial virus

    • Authors: Hiroaki Nakamura; Kenichi Akashi; Masako Watanabe; Shoichiro Ohta; Junya Ono; Yoshinori Azuma; Noriko Ogasawara; Keisuke Yamamoto; Norikazu Shimizu; Hiroyuki Tsutsumi; Kenji Izuhara; Toshio Katsunuma
      Abstract: Publication date: Available online 6 November 2017
      Source:Allergology International
      Author(s): Hiroaki Nakamura, Kenichi Akashi, Masako Watanabe, Shoichiro Ohta, Junya Ono, Yoshinori Azuma, Noriko Ogasawara, Keisuke Yamamoto, Norikazu Shimizu, Hiroyuki Tsutsumi, Kenji Izuhara, Toshio Katsunuma
      Background Periostin and squamous cell carcinoma antigen (SCCA) are involved in the pathogenesis of asthma. Acute bronchitis due to respiratory syncytial virus (RSV) infection during infancy exhibits an asthma-like pathogenesis, suggesting that it may be associated with the subsequent development of asthma. However, the mechanism by which RSV infection leads to development of asthma has not yet been fully elucidated. Methods Infants younger than 36 months were enrolled and classified into three groups. Group I included patients hospitalized with RSV-induced bronchitis. These patients were further stratified into two sub-groups according to whether the criteria for the modified Asthma Predictive Index (mAPI) had been met: Group I consisted of mAPI (+) and mAPI (−) patients; Group II included patients with food allergy as a positive control group; and Group III included children with no allergy as a negative control group. Serum periostin and SCCA levels were measured in the groups. This study was registered as a clinical trial (UMIN000012339). Results We enrolled 14 subjects in Group I mAPI (+), 22 in Group I mAPI (−), 18 in Group II, and 18 in Group III. In Group I, the serum periostin and SCCA levels were significantly higher during the acute phase compared with the recovery phase. However, no significant differences were found between Group I mAPI (+) and mAPI (−). Conclusions The serum periostin and SCCA levels increased during acute RSV bronchitis. Both periostin and SCCA may play a role in the pathogenesis of acute bronchitis due to RSV.

      PubDate: 2017-11-10T05:12:03Z
      DOI: 10.1016/j.alit.2017.10.003
  • How important is allergic sensitization as a cause of atopic asthma'

    • Authors: Jun Kanazawa; Hironori Masuko; Hideyasu Yamada; Yohei Yatagai; Tohru Sakamoto; Haruna Kitazawa; Hiroaki Iijima; Takashi Naito; Tomomitsu Hirota; Mayumi Tamari; Nobuyuki Hizawa
      Abstract: Publication date: Available online 2 November 2017
      Source:Allergology International
      Author(s): Jun Kanazawa, Hironori Masuko, Hideyasu Yamada, Yohei Yatagai, Tohru Sakamoto, Haruna Kitazawa, Hiroaki Iijima, Takashi Naito, Tomomitsu Hirota, Mayumi Tamari, Nobuyuki Hizawa

      PubDate: 2017-11-10T05:12:03Z
      DOI: 10.1016/j.alit.2017.10.005
  • Efficacy and safety of omalizumab for the treatment of refractory chronic
           spontaneous urticaria in Japanese patients: Subgroup analysis of the phase
           3 POLARIS study

    • Authors: Michihiro Hide; Atsuyuki Igarashi; Akiko Yagami; Yuko Chinuki; Naoko Inomata; Atsushi Fukunaga; Guenther Kaiser; Junyi Wang; Soichiro Matsushima; Steven Greenberg; Sam Khalil
      Abstract: Publication date: Available online 1 November 2017
      Source:Allergology International
      Author(s): Michihiro Hide, Atsuyuki Igarashi, Akiko Yagami, Yuko Chinuki, Naoko Inomata, Atsushi Fukunaga, Guenther Kaiser, Junyi Wang, Soichiro Matsushima, Steven Greenberg, Sam Khalil
      Background Omalizumab, a humanized anti-IgE monoclonal antibody, proved efficacious and well tolerated in patients with chronic spontaneous urticaria (CSU) refractory to H1 antihistamines (H1AH) in the POLARIS study (NCT02329223), a randomized, double-blind, placebo-controlled trial in East Asian patients. However, data in Japanese patients, who have specific baseline characteristics (e.g., low angioedema incidence, different background medications) that may impact clinical outcomes, are lacking. This pre-specified analysis presents additional patient-level data over time, pharmacokinetic and pharmacodynamics data for omalizumab and IgE, and efficacy and safety data for omalizumab in Japanese patients. Methods Japanese patients (N = 105) were randomized 1:1:1 to omalizumab 300 mg, 150 mg, or placebo by subcutaneous injection every 4 weeks. Efficacy and safety were assessed primarily based on changes from baseline to Week 12 in weekly itch-severity scores (ISS7) and weekly urticaria activity scores (UAS7), and incidence of adverse events (AEs), respectively. Patient-level UAS7 data over time were also reviewed. Results At Week 12, least squares mean (LSM) changes from baseline in ISS7 were greater with omalizumab vs. placebo (−9.54 and −7.29 for omalizumab 300 mg and 150 mg, respectively, vs. placebo [−5.17]). Corresponding LSM changes from baseline in UAS7 were −21.61 and −15.59 (vs. placebo [−10.88]). Most responders in the omalizumab 300 mg group displayed improvement of disease activity within 2–4 weeks and had well-controlled symptoms during the treatment period. Overall AE incidence was similar across treatment arms. Conclusions This subgroup analysis demonstrated that omalizumab is a well-tolerated, beneficial option for treatment of CSU in H1AH-refractory Japanese patients.

      PubDate: 2017-11-10T05:12:03Z
      DOI: 10.1016/j.alit.2017.10.001
  • Successful treatment of refractory alopecia universalis by persuading a
           patient not to sleep with her dog

    • Authors: Takahiro Arita; Tomoko Nomiyama; Jun Asai; Norito Katoh
      Abstract: Publication date: Available online 31 October 2017
      Source:Allergology International
      Author(s): Takahiro Arita, Tomoko Nomiyama, Jun Asai, Norito Katoh

      PubDate: 2017-11-10T05:12:03Z
      DOI: 10.1016/j.alit.2017.06.011
  • Phenotype classification using the combination of lung sound analysis and
           fractional exhaled nitric oxide for evaluating asthma treatment

    • Authors: Terufumi Shimoda; Yasushi Obase; Yukio Nagasaka; Sadahiro Asai
      Abstract: Publication date: Available online 21 October 2017
      Source:Allergology International
      Author(s): Terufumi Shimoda, Yasushi Obase, Yukio Nagasaka, Sadahiro Asai
      Background We report the utility of combining lung sound analysis and fractional exhaled nitric oxide (FeNO) for phenotype classification of airway inflammation in patients with bronchial asthma. We investigated the usefulness of the combination of the expiration-to-inspiration sound power ratio in the mid-frequency range (E/I MF) of 200–400 Hz and FeNO for comprehensively classifying disease type and evaluating asthma treatment. Methods A total of 233 patients with bronchial asthma were included. The cutoff values of FeNO and E/I MF were set to 38 ppb and 0.36, respectively, according to a previous study. The patients were divided into 4 subgroups based on the FeNO and E/I MF cutoff values. Respiratory function, the percentages of sputum eosinophils and neutrophils, and patient background characteristics were compared among groups. Results Respiratory function was well controlled in the FeNO low/E/I MF low group (good control). Sputum neutrophil was higher and FEV1,%pred was lower in the FeNO low/E/I MF high group (poor control). History of childhood asthma and atopic asthma were associated with the FeNO high/E/I MF low group (insufficient control). The FeNO high/E/I MF high group corresponded to a longer disease duration, increased blood or sputum eosinophils, and lower FEV1/FVC (poor control). Conclusions The combination of FeNO and E/I MF assessed by lung sound analysis allows the condition of airway narrowing and the degree of airway inflammation to be assessed in patients with asthma and is useful for evaluating bronchial asthma treatments.

      PubDate: 2017-11-10T05:12:03Z
      DOI: 10.1016/j.alit.2017.09.004
  • Chronic spontaneous urticaria and the extrinsic coagulation system

    • Authors: Yuhki Yanase; Satoshi Morioke; Kazumasa Iwamoto; Shunsuke Takahagi; Kazue Uchida; Tomoko Kawaguchi; Kaori Ishii; Izumi Hide; Michihiro Hide
      Abstract: Publication date: Available online 6 October 2017
      Source:Allergology International
      Author(s): Yuhki Yanase, Shunsuke Takahagi, Michihiro Hide
      Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch. Recently, the activation of the blood coagulation cascade has been suggested to be involved in CSU, but the trigger of the coagulation cascade remains unclear. In this article, we review recent understanding of the relationship between the pathogenesis of CSU and extrinsic coagulation reactions. In CSU, vascular endothelial cells and eosinophils may play a role as TF-expressing cells for activating the extrinsic coagulation pathway. Moreover, the expression of TF on endothelial cells is synergistically enhanced by the activation of Toll-like receptors and histamine H1 receptors. The activated coagulation factors may induce plasma extravasation followed by degranulation of skin mast cells and edema formation recognized as wheal in CSU. Molecules involved in this cascade could be a target for new and more effective treatments of urticaria.

      PubDate: 2017-10-07T15:22:34Z
      DOI: 10.1016/j.jaci.2017.07.026
  • Role of airway epithelial barrier dysfunction in pathogenesis of asthma

    • Authors: Yasuhiro Gon; Shu Hashimoto
      Abstract: Publication date: Available online 21 September 2017
      Source:Allergology International
      Author(s): Yasuhiro Gon, Shu Hashimoto
      Bronchial asthma is characterized by persistent cough, increased sputum, and repeated wheezing. The pathophysiology underlying these symptoms is the hyper-responsiveness of the airway along with chronic airway inflammation. Repeated injury, repair, and regeneration of the airway epithelium following exposure to environmental factors and inflammation results in histological changes and functional abnormalities in the airway mucosal epithelium; such changes are believed to have a significant association with the pathophysiology of asthma. Damage to the barrier functions of the airway epithelium enhances mucosal permeability of foreign substances in the airway epithelium of patients with asthma. Thus, epithelial barrier fragility is closely involved in releasing epithelial cytokines (e.g., TSLP, IL-25, and IL-33) because of the activation of airway epithelial cells, dendritic cells, and innate group 2 innate lymphoid cells (ILC2). Functional abnormalities of the airway epithelial cells along with the activation of dendritic cells, Th2 cells, and ILC2 form a single immunopathological unit that is considered to cause allergic airway inflammation. Here we use the latest published literature to discuss the potential pathological mechanisms regarding the onset and progressive severity of asthma with regard to the disruption of the airway epithelial function.

      PubDate: 2017-09-24T04:28:02Z
      DOI: 10.1016/j.alit.2017.08.011
  • Development of the gut microbiota in infancy and its impact on health in
           later life

    • Authors: Masaru Tanaka; Jiro Nakayama
      Abstract: Publication date: Available online 18 August 2017
      Source:Allergology International
      Author(s): Masaru Tanaka, Jiro Nakayama
      Gut microbial ecology and function are dynamic in infancy, but are stabilized in childhood. The ‘new friends’ have a great impact on the development of the digestive tract and host immune system. In the first year of life, especially, the gut microbiota dramatically changes through interactions with the developing immune system in the gut. The process of establishing the gut microbiota is affected by various environmental factors, with the potential to be a main determinant of life-long health. In this review, we summarize recent findings regarding gut microbiota establishment, including the importance of various factors related to the development of the immune system and allergic diseases later in life.

      PubDate: 2017-08-21T04:00:18Z
      DOI: 10.1016/j.alit.2017.07.010
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