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Publisher: Elsevier   (Total: 3043 journals)

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Showing 1 - 200 of 3043 Journals sorted alphabetically
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 22, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 21, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 84, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 25, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 30, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 4)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 5, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 350, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 3)
Acta Biomaterialia     Hybrid Journal   (Followers: 25, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 1)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 240, SJR: 3.683, h-index: 202)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.615, h-index: 21)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 10, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription   (Followers: 1)
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 3, SJR: 0.311, h-index: 16)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 2)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 23, SJR: 1.365, h-index: 73)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 4)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 4, SJR: 0.383, h-index: 19)
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Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 5, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 4, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 4)
Acute Pain     Full-text available via subscription   (Followers: 13)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 5)
Additive Manufacturing     Hybrid Journal   (Followers: 7, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 21)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 135, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 17, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 9, SJR: 0.299, h-index: 15)
Advances in Agronomy     Full-text available via subscription   (Followers: 15, SJR: 2.071, h-index: 82)
Advances in Anesthesia     Full-text available via subscription   (Followers: 25, SJR: 0.169, h-index: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 3)
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Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
Advances in Botanical Research     Full-text available via subscription   (Followers: 3, SJR: 0.619, h-index: 48)
Advances in Cancer Research     Full-text available via subscription   (Followers: 25, SJR: 2.215, h-index: 78)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 0.9, h-index: 30)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 2.139, h-index: 42)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 26, SJR: 0.183, h-index: 23)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 9, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 29, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 16, SJR: 0.223, h-index: 22)
Advances in Dermatology     Full-text available via subscription   (Followers: 12)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 11)
Advances in Digestive Medicine     Open Access   (Followers: 6)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Ecological Research     Full-text available via subscription   (Followers: 41, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 25, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 7)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 41, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 3)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 50, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 16)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 22, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 0.497, h-index: 31)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 35, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 3, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6)
Advances in Life Course Research     Hybrid Journal   (Followers: 8, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 2)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Marine Biology     Full-text available via subscription   (Followers: 16, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 22)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 10)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 4)
Advances in Oncobiology     Full-text available via subscription   (Followers: 3)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 24, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 13)
Advances in Pharmacology     Full-text available via subscription   (Followers: 15, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 4)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 17)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 61)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.1, h-index: 2)
Advances in Space Research     Full-text available via subscription   (Followers: 353, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 8)
Advances in Surgery     Full-text available via subscription   (Followers: 7, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 30, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 17)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 43, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 5, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 325, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 5, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 8, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 405, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 30, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 39, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access  
Agriculture and Natural Resources     Open Access   (Followers: 1)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 54, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 5, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 10, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 8)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access  
Algal Research     Partially Free   (Followers: 8, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 4, SJR: 0.776, h-index: 35)
Alpha Omegan     Full-text available via subscription   (SJR: 0.121, h-index: 9)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 8, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 48, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 6)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 5)
American Heart J.     Hybrid Journal   (Followers: 49, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 47, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 39, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 8, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 15, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 31, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 25, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 32, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 45, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 237, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 57, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 5)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 25, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 26, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 22, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 34, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 5)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 57, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 11)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 4, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 37, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 166, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 8, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 11)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 1)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 22, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access  
Animal Behaviour     Hybrid Journal   (Followers: 160, SJR: 1.907, h-index: 126)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 5, SJR: 1.151, h-index: 83)
Animal Reproduction Science     Hybrid Journal   (Followers: 5, SJR: 0.711, h-index: 78)
Annales d'Endocrinologie     Full-text available via subscription   (Followers: 1, SJR: 0.394, h-index: 30)
Annales d'Urologie     Full-text available via subscription  
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (SJR: 0.177, h-index: 13)
Annales de Chirurgie de la Main et du Membre Supérieur     Full-text available via subscription  
Annales de Chirurgie Plastique Esthétique     Full-text available via subscription   (Followers: 2, SJR: 0.354, h-index: 22)
Annales de Chirurgie Vasculaire     Full-text available via subscription   (Followers: 1)

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Journal Cover Allergology International
  [SJR: 0.776]   [H-I: 35]   [4 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 1323-8930 - ISSN (Online) 1440-1592
   Published by Elsevier Homepage  [3043 journals]
  • Old friends, microbes, and allergic diseases

    • Authors: Naoki Shimojo; Kenji Izuhara
      Pages: 513 - 514
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Naoki Shimojo, Kenji Izuhara


      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.08.009
       
  • Effectiveness of training patients using DVD in the accurate use
           of inhalers for the treatment of bronchial asthma

    • Authors: Koichiro Takita; Rieko Kondo; Takahiko Horiguchi
      Pages: 545 - 549
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Koichiro Takita, Rieko Kondo, Takahiko Horiguchi
      Background Inhalants are the standard treatment for patients with bronchial asthma. Inaccurate inhaler use leads to inadequate therapeutic effects and unnecessary dosage increases. However, it is a challenge for practitioners to master the various devices available and train patients on the accurate use of inhalers. Thus, establishing a system to instruct patients on how to accurately use inhalers is essential. We prepared a DVD and accompanying user manual explaining the operation of each inhaler device used in Japan. This pilot study aimed to examine the efficacy of these materials. Methods The subjects were 33 outpatients with bronchial asthma who received treatment in our facility for asthma and had already received conventional inhalant training. The oral medication and inhalants used by the patients were not changed. The patients were randomly assigned to a DVD viewing group or non-viewing group; various parameters were comparatively examined after 4 weeks. Results Significant improvements in Asthma Control Test scores, inhalation technique, forced vital capacity, forced expiratory volume in 1 s, impulse oscillometry resonant frequency, and induced sputum eosinophil count were observed in the DVD viewing group at 4 weeks post training. Conclusions Pulmonary function and inflammatory parameters improved significantly in the DVD viewing group. These findings suggest that unnecessary step-up of asthma treatment can be avoided, leading to treatment cost reduction. Training patients with asthma in accurate inhaler use improves quality of life and therefore has great clinical significance. Hence, this method should be used more extensively in Japan and worldwide.

      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.02.006
       
  • Phenotypic analysis of asthma in Japanese athletes

    • Authors: Keisuke Tsukioka; Toshiyuki Koya; Hiroshi Ueno; Masachika Hayashi; Takuro Sakagami; Takashi Hasegawa; Masaaki Arakawa; Eiichi Suzuki; Toshiaki Kikuchi
      Pages: 550 - 556
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Keisuke Tsukioka, Toshiyuki Koya, Hiroshi Ueno, Masachika Hayashi, Takuro Sakagami, Takashi Hasegawa, Masaaki Arakawa, Eiichi Suzuki, Toshiaki Kikuchi
      Background Asthma in athlete populations such as Olympic athletes has various pathogeneses. However, few reports are available on the features of asthma in the athlete population in clinical practice. In this study, we focused on classifying asthma in Japanese athlete population. Methods We performed a cluster analysis of data from pulmonary function tests and clinical biomarkers before administering inhaled corticosteroids (ICS) therapy in athlete population of individuals diagnosed with asthma (n = 104; male, 76.9%; median age, 16.0 years), based on respiratory symptoms and positive data on methacholine provocation tests. We also compared backgrounds, sports types, and treatments between clusters. Results Three clusters were identified. Cluster 1 (32%) comprised athletes with a less atopic phenotype and normal pulmonary function. Cluster 2 (44%) comprised athletes with a less atopic phenotype and lower percent predicted forced expiratory volume in 1 s (%FEV1) values, despite less symptomatic state. Cluster 3 (24%) comprised athletes with a strong atopic phenotype such as high eosinophil count in the blood and total serum immunoglobulin E level. After treatment with ICS or ICS plus long-acting β-adrenergic receptor agonist for 6–12 months, %FEV1 values were significantly improved in Cluster 2 athletes, whereas Cluster 3 athletes had a significant decrease in the fraction of exhaled nitric oxide compared to pretreatment values. Conclusions These data suggest three clusters exist in Japanese athlete population with asthma. Between the clusters, the characteristics differed with regard to symptoms, atopic features, and lower %FEV1 values. The pathogeneses between clusters may vary depending on the inflammation type and airway hyperresponsiveness.

      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.02.009
       
  • Epidemiology of drug-induced anaphylaxis in a tertiary hospital in Korea

    • Authors: Han-Ki Park; Min-Gyu Kang; Min-Suk Yang; Jae-Woo Jung; Sang-Heon Cho; Hye-Ryun Kang
      Pages: 557 - 562
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Han-Ki Park, Min-Gyu Kang, Min-Suk Yang, Jae-Woo Jung, Sang-Heon Cho, Hye-Ryun Kang
      Background Epidemiology and risk factors of drug-induced anaphylaxis are difficult to estimate due to lack of confirmative diagnosis and under reporting. Here we report the current state of drug-induced anaphylaxis in Korea based on an in-hospital pharmacovigilance database in a tertiary hospital. Methods This study is a retrospective analysis of drug-induced anaphylaxis, reported to an in-hospital pharmacovigilance center in Seoul National University Hospital from June 2009 to May 2013. Anaphylaxis occurred in patients under 18 years of age or developed by medications administered from outside pharmacies or hospitals were excluded. We assessed causative drug, incidence per use of each drug and risk factors of fatal anaphylactic shock. Results A total of 152 in-hospital drug-induced anaphylaxis cases were reported during the study period. The single most frequently reported drug was platinum compound and the incidence of anaphylaxis and anaphylactic shock in platinum compounds users was 2.84 and 1.39 per 1000 patients use. Risk factors of anaphylactic shock among total anaphylaxis cases were identified as older age ≥70 years [Odd's ratio (OR), 5.86; 95% confidence interval (CI), 1.70–20.14]. The use of iodinated contrast media (OR, 6.19; 95% CI, 1.87–20.53) and aminosteroid neuromuscular blocking agent (NMBA) (OR, 12.82; 95% CI, 1.50–109.92) were also a risk factor for the development of anaphylactic shock. Conclusions Platinum compounds are the most commonly reported causative agents of in-hospital drug-induced anaphylaxis. Older age ≥70 years and drugs such as iodinated contrast media and aminosteroid NMBA are related with high risk of anaphylactic shock.

      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.02.008
       
  • Genetic association of the functional CDHR3 genotype with early-onset
           adult asthma in Japanese populations

    • Authors: Jun Kanazawa; Hironori Masuko; Yohei Yatagai; Tohru Sakamoto; Hideyasu Yamada; Yoshiko Kaneko; Haruna Kitazawa; Hiroaki Iijima; Takashi Naito; Takefumi Saito; Emiko Noguchi; Satoshi Konno; Masaharu Nishimura; Tomomitsu Hirota; Mayumi Tamari; Nobuyuki Hizawa
      Pages: 563 - 567
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Jun Kanazawa, Hironori Masuko, Yohei Yatagai, Tohru Sakamoto, Hideyasu Yamada, Yoshiko Kaneko, Haruna Kitazawa, Hiroaki Iijima, Takashi Naito, Takefumi Saito, Emiko Noguchi, Satoshi Konno, Masaharu Nishimura, Tomomitsu Hirota, Mayumi Tamari, Nobuyuki Hizawa
      Background Recent studies have demonstrated that a coding SNP (rs6967330, Cys529→Tyr) in cadherin-related family member 3 (CDHR3), which was previously associated with wheezing illness and hospitalizations in infancy, could support efficient human rhinovirus C (RV-C) entry and replication. Here, we sought to examine the genetic contribution of this variant to the development of adult asthma. Methods We performed a candidate gene case–control association study of 2 independent Japanese populations (a total of 3366 adults). The odds ratios (ORs) for association of the A allele at rs6967330 with adult asthma were calculated according to age at onset of asthma. In addition, the effect of the CDHR3 genotype on the development of specific asthma phenotypes was examined. Results The A allele was associated with asthma (OR = 1.56; Mantel–Haenszel p = 0.0040) when the analysis was limited to patients with early-onset adult asthma. In addition, when the analysis was limited to atopic individuals, a stronger association of the CDHR3 variant with early-onset asthma was found, and interaction of the CDHR3 genotype with atopy was demonstrated. Finally, a significant association of this variant was specifically found with a phenotype of asthma characterized by atopy, early-onset, and lower lung function. Conclusions Our study supports the concept that the CDHR3 variant is an important susceptibility factor for severe adult asthma in individuals who develop the disease in early life. The interaction between the CDHR3 variant and atopy indicates that genetic predisposition to early respiratory viral infection is combined with atopy in promoting asthma.

      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.02.012
       
  • Predicting future risk of exacerbations in Japanese patients with adult
           asthma: A prospective 1-year follow up study

    • Authors: Akihiko Tanaka; Tomoki Uno; Haruna Sato; Megumi Jinno; Kuniaki Hirai; Yoshito Miyata; Munehiro Yamaguchi; Shin Ohta; Tetsuya Homma; Mayumi Yamamoto; Shintaro Suzuki; Takuya Yokoe; Hironori Sagara
      Pages: 568 - 573
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Akihiko Tanaka, Tomoki Uno, Haruna Sato, Megumi Jinno, Kuniaki Hirai, Yoshito Miyata, Munehiro Yamaguchi, Shin Ohta, Tetsuya Homma, Mayumi Yamamoto, Shintaro Suzuki, Takuya Yokoe, Hironori Sagara
      Background To avoid future risk is a definitive goal of long-term asthma management. Exacerbations are considered to be the most relevant future risk in real life asthma management. Few comparative studies have evaluated the risk factors associated with exacerbations in Japanese patients with asthma. Methods We performed the prospective 1-year follow up study in Japanese patients with adult asthma. A total of 189 patients with asthma were enrolled and followed up for 1 year. Finally, 181 patients completed the study protocol. Results Of 181 patients, 43 patients (23.8%) had exacerbations during the follow-up period. Among the 45 patients who had exacerbations during the preceding year, 32 patients (71.1%) had exacerbations. Prevalence of patients with previous exacerbations and those with previous admissions were significantly higher in patients with exacerbations than those with no exacerbation. Logistic regression analysis also identified a significant association between exacerbations during the follow-up period and exacerbations during the preceding year, admissions during the preceding 3 years, ACT score below 20, low %FVC (<80%), or low FEV1 (<70%), respectively. Of the 55 patients with severe asthma, 29 patients (52.7%) had exacerbations. Among the 36 patients with severe asthma with previous exacerbations, 26 patients (72.2%) had exacerbations. The history of exacerbations during the preceding year was associated with a significantly increased risk of exacerbations both among the patients with severe asthma and those with non-severe asthma. Conclusions This study implicated that exacerbations during the preceding year reliably predict future risk of exacerbations in Japanese patients with asthma.

      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.02.013
       
  • UDP/P2Y6 receptor signaling regulates IgE-dependent degranulation in human
           basophils

    • Authors: Manabu Nakano; Koichi Ito; Takeo Yuno; Nobuyuki Soma; Syun Aburakawa; Kosuke Kasai; Toshiya Nakamura; Hideki Takami
      Pages: 574 - 580
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Manabu Nakano, Koichi Ito, Takeo Yuno, Nobuyuki Soma, Syun Aburakawa, Kosuke Kasai, Toshiya Nakamura, Hideki Takami
      Background P2Y purinergic receptors (P2YR) are G protein-coupled receptors that are stimulated by extracellular nucleotides. They mediate cellular effects by regulating cAMP production, protein kinase C activation, inositol trisphosphate generation, and Ca2+ release from intracellular stores. The P2Y6 receptor of this family is selectively stimulated by UDP, and selectively inhibited by MRS2578. In the present study, we examined the effect of UDP/P2Y6 receptor signaling on IgE-dependent degranulation in human basophils. Methods Basophils were purified from human peripheral blood. The mRNA expression of genes encoding P2YR and ecto-nucleoside triphosphate diphosphohydrolase (ENTPDase) was measured by RT-PCR. Intracellular Ca2+ influx via UDP/P2Y6 receptor signaling in basophils was detected using a calcium probe. The effect of UDP/P2Y6 receptor signaling on IgE-dependent degranulation in basophils was confirmed by measuring CD63 expression by flow cytometry. Autocrine secretion of nucleotides was detected by HPLC analysis. Results We showed that purified basophils express P2Y6 mRNA and that UDP increased intracellular Ca2+, which was reduced by MRS2578 treatment. UDP promoted IgE-dependent degranulation. Furthermore, MRS2578 inhibited IgE-dependent degranulation in basophils. HPLC analysis indicated that basophils spontaneously secrete UTP. In addition, basophils expressed the extracellular nucleotide hydrolases ENTPDase2, ENTPDase3, and ENTPDase8. Conclusions This study showed that UDP/P2Y6 receptor signaling is involved in the regulation of IgE-dependent degranulation in basophils, which might stimulate the P2Y6 receptor via the autocrine secretion of UTP. Thus, this receptor represents a potential target to regulate IgE-dependent degranulation in basophils during allergic diseases.

      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.02.014
       
  • Histamine H1 and H4 receptor expression on the ocular surface of patients
           with chronic allergic conjunctival diseases

    • Authors: Noriko Inada; Jun Shoji; Yukiko Shiraki; Hiroshi Aso; Satoru Yamagami
      Pages: 586 - 593
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Noriko Inada, Jun Shoji, Yukiko Shiraki, Hiroshi Aso, Satoru Yamagami
      Background This study investigated the histamine H1 and H4 receptors mRNA (H1R and H4R, respectively) expression on the ocular surface of patients with chronic forms of allergic conjunctival diseases to determine whether they can serve as biomarkers for allergic inflammation in the conjunctiva. Methods We examined 19 patients with vernal or atopic keratoconjunctivitis (AKC/VKC group) and 15 healthy volunteers (control group). The AKC/VKC group was divided into active and stable stage subgroups. Specimens were obtained from the upper tarsal conjunctiva of each participant using a modified impression cytology method. H1R, H4R, and eotaxin-1, -2, and -3 mRNA (eotaxin-1, eotaxin-2, eotaxin-3, respectively) expression was determined by real-time RT-PCR. Immunohistochemical analysis for eosinophil cationic protein (ECP), eosinophil major basic protein (MBP), eotaxin-2, and histamine H4 receptor (H4R) were performed using conjunctival smears. Results The number of H4R-positive patients was higher in the active than the stable stage subgroup and control group, whereas no difference was observed for H1R. H1R levels were higher in the active than in the stable stage subgroup, while those of H4R were higher in the active stage subgroup than in the control group. H1R and H4R levels were correlated with eotaxin-2 level. In immunohistochemical analysis, H4R revealed their expression on eosinophils in conjunctival smears of patients with AKC/VKC. Conclusions H4R is useful as biomarkers of allergic inflammation on ocular surfaces. Most notably, H4R expressed on eosinophils is useful as a biomarker of eosinophilic inflammation of the ocular surface.

      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.03.004
       
  • Nattokinase, profibrinolytic enzyme, effectively shrinks the nasal polyp
           tissue and decreases viscosity of mucus

    • Authors: Tetsuji Takabayashi; Yoshimasa Imoto; Masafumi Sakashita; Yukinori Kato; Takahiro Tokunaga; Kanako Yoshida; Norihiko Narita; Tamotsu Ishizuka; Shigeharu Fujieda
      Pages: 594 - 602
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Tetsuji Takabayashi, Yoshimasa Imoto, Masafumi Sakashita, Yukinori Kato, Takahiro Tokunaga, Kanako Yoshida, Norihiko Narita, Tamotsu Ishizuka, Shigeharu Fujieda
      Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is often comorbid with asthma and resistant to therapeutic interventions. We recently reported that excessive fibrin deposition caused by impairment of fibrinolysis might play pivotal role in forming nasal polyp. Nattokinase (NK), a serine protease produced by Bacillus subtilis, has been reported to be a strong fibrinolytic enzyme. NK could be a promising drug candidate for use in the treatment of both CRSwNP and asthma. The objective of this study was to investigate the effects of NK on nasal polyp tissues from patients with CRSwNP. The nasal discharge from patients with CRSwNP and sputum from subjects with asthma were also used to investigate whether NK influences the viscosity of mucus. Methods To examine the effects on NK on nasal polyp tissues, pieces of nasal polyps were incubated either with saline or NK (10–1000 FU/ml) at 37 °C for 24 h. We assessed the presence of fibrin in nasal polyp tissue incubated with NK by means of immunohistochemistry. To examine the effects of NK on nasal discharge and sputum from patients with CRSwNP and asthma, respectively, were incubated with NK solution at 37 °C for 1 h. Results NK effectively shrinks the nasal polyp tissue through fibrin degradation. We also found that the viscosity of the nasal discharge and sputum from patients with CRSwNP and asthma, respectively, was significantly reduced by incubation with NK solution. Conclusions NK may be an effective alternative therapeutic option in patients with CRSwNP and comorbid asthma by causing fibrin degradation.

      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.03.007
       
  • Diminished capacity of opsonization and immune complex solubilization, and
           detection of anti-C1q antibodies in sera from patients with hereditary
           angioedema

    • Authors: Daisuke Honda; Isao Ohsawa; Nobuyuki Sato; Hiroyuki Inoshita; Satoshi Mano; Yasuhiko Tomino; Yusuke Suzuki
      Pages: 603 - 609
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Daisuke Honda, Isao Ohsawa, Nobuyuki Sato, Hiroyuki Inoshita, Satoshi Mano, Yasuhiko Tomino, Yusuke Suzuki
      Background Hereditary angioedema (HAE) is an autosomal dominant disease caused by deficiency of C1 esterase inhibitor. Symptoms of HAE include edema, which can potentially cause suffocation. Some patients with HAE exhibit immunological abnormalities, which could prevent an accurate diagnosis. Low levels of complement components are characteristic of HAE and in other settings are thought to reduce elimination of apoptotic cells and immune complex (IC). Thus, we aimed to experimentally clarify the mechanism of immunological abnormalities using sera from HAE patients. Methods Serum samples from 18 patients with HAE were collected when free from angioedema attack and compared with normal human pooled sera (NHPS) from 20 healthy volunteers. Opsonization was measured as the rate of phagocytosis of apoptotic Jurkat cells by macrophages differentiated from THP-1 cells incubated with serum. IC solubilization in serum was analyzed by quantifying peroxidase released from a synthetic IC composed of peroxidase and anti-peroxidase antibodies. Anti-C1q antibody levels were detected using an enzyme-linked immunosorbent assay. Results Serological immunological abnormalities were detected in 12 patients. Opsonization in serum samples from each patient with HAE was lower than that in NHPS (∼20% versus 70%, respectively). The rate of IC solubilization was lower in serum from HAE patients than NHPS. Some patients had high serum anti-C1q antibody levels with increased serum IC levels. Conclusions Sera from patients with HAE exhibit anti-C1q antibodies, with a lower capacity for opsonization and IC solubilization. This may be associated with immunological abnormalities and should be investigated further to facilitate accurate diagnosis of HAE.
      Graphical abstract image

      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.03.008
       
  • The significant expression of TRPV3 in nasal polyps of eosinophilic
           chronic rhinosinusitis

    • Authors: Takahiro Tokunaga; Takahiro Ninomiya; Yukinori Kato; Yoshimasa Imoto; Masafumi Sakashita; Tetsuji Takabayashi; Emiko Noguchi; Shigeharu Fujieda
      Pages: 610 - 616
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Takahiro Tokunaga, Takahiro Ninomiya, Yukinori Kato, Yoshimasa Imoto, Masafumi Sakashita, Tetsuji Takabayashi, Emiko Noguchi, Shigeharu Fujieda
      Background The number of patients with eosinophilic chronic rhinosinusitis (ECRS) has been increasing in recent years in Japan. In ECRS, nasal polyps recur immediately after endoscopic sinus surgery. The molecular biological mechanism underlying the refractoriness of ECRS is unclear. Methods Whole-transcriptome analysis with next-generation sequencing (RNA-seq) was conducted to investigate the molecular biological mechanism of ECRS. Real-time PCR, immunohistochemical staining, and immunofluorescence staining were performed to validate the results of RNA-seq. Results RNA-seq analysis revealed that in the nasal polyps of ECRS, the levels of 3 transcripts were elevated significantly and those of 7 transcripts were diminished significantly. Among the genes encoding these transcripts, TRPV3 (transient receptor potential cation channel, subfamily V, member 3) was identified as the only gene that is highly expressed in ECRS nasal polyps but this gene's expression was not previously detected using DNA microarray analysis in peripheral blood eosinophils. TRPV3 is newly identified here as a gene transcribed in ECRS. Our analysis also revealed that TRPV3 was highly expressed in the infiltrating eosinophils and mucosal epithelium of the nasal polyps of ECRS, and further that the more severe the refractoriness was after surgery, the higher the TRPV3 expression was in nasal polyps. Conclusions TRPV3 might play a role in the refractoriness of ECRS. Additional studies are required to evaluate the function of TRPV3 in ECRS.
      Graphical abstract image

      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.04.002
       
  • A retrospective study: Acute rheumatic fever and post-streptococcal
           reactive arthritis in Japan

    • Authors: Satoshi Sato; Yoji Uejima; Eisuke Suganuma; Tadamasa Takano; Yutaka Kawano
      Pages: 617 - 620
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Satoshi Sato, Yoji Uejima, Eisuke Suganuma, Tadamasa Takano, Yutaka Kawano
      Background Acute rheumatic fever (ARF) and post-streptococcal reactive arthritis (PSRA) are immune-mediated consequences of group A streptococcal pharyngitis. ARF has declined in developed nations. No prevalence survey of PSRA has been conducted. This study evaluated the incidence and characteristics of ARF and PSRA in Japanese children. Methods From 2010 to 2015, ARF and PSRA were evaluated using clinical data retrospectively collected by chart review from 528 hospitals. Results From 323 hospitals (61% response rate), 44 cases of ARF and 21 cases of PSRA were reported. Patients with ARF and/or PSRA were mainly from large cities in Japan. The mean age of ARF occurrence was 8.5 years, and the ratio of female/male patients was 16:28. Major manifestations in the acute phase included carditis, 27 cases (61.4%); polyarthritis, 22 cases (50%); erythema marginatum, 7 cases (15.9%); Sydenham chorea, 3 cases (6.8%); and subcutaneous nodules, 1 case (2.3%). Twenty-one (58.3%) patients had migratory arthritis. During the follow-up period, 6 patients (13.6%) showed mild carditis. For PRSA, the mean age was 8.2 years, and the ratio of female/male patients was 12:9. Six (28.6%) patients had monoarthritis, and 4 (19%) patients had migratory arthritis. No patient had carditis. Conclusions Although ARF and PSRA are rare in the Japanese pediatric population, substantial numbers of patients with both conditions were identified in this study. We observed a high incidence of arthritis and carditis in ARF patients. No PSRA case was complicated with carditis. General pediatricians need to have updated information about ARF and PSRA, even in industrialized countries.

      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.04.001
       
  • Eosinophilic gastroenteritis caused by eating hens' eggs: A case report

    • Authors: Yoshitoki Yanagimoto; Shoichiro Taniuchi; Yuko Ishizaki; Keiji Nakano; Naoki Hosaka; Kazunari Kaneko
      Pages: 621 - 623
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Yoshitoki Yanagimoto, Shoichiro Taniuchi, Yuko Ishizaki, Keiji Nakano, Naoki Hosaka, Kazunari Kaneko


      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.02.007
       
  • Utility of serum YKL-40 levels for identification of patients with asthma
           and COPD

    • Authors: Yasuhiro Gon; Shuichiro Maruoka; Reiko Ito; Kenji Mizumura; Yutaka Kozu; Hisato Hiranuma; Tomohiro Hattori; Mai Takahashi; Mari Hikichi; Shu Hashimoto
      Pages: 624 - 626
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Yasuhiro Gon, Shuichiro Maruoka, Reiko Ito, Kenji Mizumura, Yutaka Kozu, Hisato Hiranuma, Tomohiro Hattori, Mai Takahashi, Mari Hikichi, Shu Hashimoto


      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.02.010
       
  • Probability curves for predicting symptom severity during an oral food
           challenge with wheat

    • Authors: Naomi Kamioka; Takayasu Nomura; Taisuke Kato; Mizuki Yoneyama; Takehiro Sobajima; Hisashi Tanida; Takehiro Morishita; Shiro Sugiura; Yuichiro Suda; Yasutaka Hirabayashi; Chieko Misawa; Hidenori Tanaka; Mihoko Mizuno; Akihiko Terada; Yasushi Kanda; Shinji Saitoh
      Pages: 627 - 628
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Naomi Kamioka, Takayasu Nomura, Taisuke Kato, Mizuki Yoneyama, Takehiro Sobajima, Hisashi Tanida, Takehiro Morishita, Shiro Sugiura, Yuichiro Suda, Yasutaka Hirabayashi, Chieko Misawa, Hidenori Tanaka, Mihoko Mizuno, Akihiko Terada, Yasushi Kanda, Shinji Saitoh


      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.02.011
       
  • Pustular allergic contact dermatitis caused by Disperse Yellow 3 in a dark
           blue dress

    • Authors: Eri Hotta; Risa Tamagawa-Mineoka; Koji Masuda; Norito Katoh
      Pages: 629 - 631
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Eri Hotta, Risa Tamagawa-Mineoka, Koji Masuda, Norito Katoh


      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.03.001
       
  • Patch testing in patients with recurrent vesicular hand eczema

    • Authors: Risa Tamagawa-Mineoka; Naomi Nakamura; Sachiko Ueda; Koji Masuda; Norito Katoh
      Pages: 632 - 633
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Risa Tamagawa-Mineoka, Naomi Nakamura, Sachiko Ueda, Koji Masuda, Norito Katoh


      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.03.006
       
  • A case of refractory chronic rhinosinusitis with anti-desmoglein 3 IgG4
           autoantibody

    • Authors: Yasushi Ota; Fumio Ishikawa; Toshiya Sato; Nobuyuki Hiruta; Makoto Kitamura; Hiromitsu Yokota; Yoshihiro Ikemiyagi; Hideaki Bujo; Mutsunori Fujiwara; Mitsuya Suzuki
      Pages: 634 - 636
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Yasushi Ota, Fumio Ishikawa, Toshiya Sato, Nobuyuki Hiruta, Makoto Kitamura, Hiromitsu Yokota, Yoshihiro Ikemiyagi, Hideaki Bujo, Mutsunori Fujiwara, Mitsuya Suzuki


      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.04.009
       
  • Preface to the proceedings of the Workshop on Eosinophils in Allergy and
           Related Diseases 2016

    • Authors: Kohei Yamauchi
      Abstract: Publication date: September 2017
      Source:Allergology International, Volume 66, Supplement
      Author(s): Kohei Yamauchi


      PubDate: 2017-09-06T04:13:05Z
      DOI: 10.1016/j.alit.2017.08.006
       
  • Neuropsychiatry phenotype in asthma: Psychological stress-induced
           alterations of the neuroendocrine-immune system in allergic airway
           inflammation

    • Authors: Isao Ohno
      Abstract: Publication date: September 2017
      Source:Allergology International, Volume 66, Supplement
      Author(s): Isao Ohno
      Since the recognition of asthma as a syndrome with complex pathophysiological signs and symptoms, recent research has sought to classify asthma phenotypes based on its clinical and molecular pathological features. Psychological stress was first recognized as a potential immune system modulator of asthma at the end of the 19th century. The activation of the central nervous system (CNS) upon exposure to psychological stress is integral for the initiation of signal transduction processes. The stress hormones, including glucocorticoids, epinephrine, and norepinephrine, which are secreted following CNS activation, are involved in the immunological alterations involved in psychological stress-induced asthma exacerbation. The mechanisms underlying this process may involve a pathological series of events from the brain to the lungs, which is attracting attention as a conceptually advanced phenotype in asthma pathogenesis. This review presents insights into the critical role of psychological stress in the development and exacerbation of allergic asthma, with a special focus on our own data that emphasizes on the continuity from the central sensing of psychological stress to enhanced eosinophilic airway inflammation.

      PubDate: 2017-09-06T04:13:05Z
      DOI: 10.1016/j.alit.2017.06.005
       
  • The dual regulation of substance P-mediated inflammation via human
           synovial mast cells in rheumatoid arthritis

    • Authors: Yuki Okamura; Shintaro Mishima; Jun-ichi Kashiwakura; Tomomi Sasaki-Sakamoto; Shota Toyoshima; Kazumichi Kuroda; Shu Saito; Yasuaki Tokuhashi; Yoshimichi Okayama
      Abstract: Publication date: September 2017
      Source:Allergology International, Volume 66, Supplement
      Author(s): Yuki Okamura, Shintaro Mishima, Jun-ichi Kashiwakura, Tomomi Sasaki-Sakamoto, Shota Toyoshima, Kazumichi Kuroda, Shu Saito, Yasuaki Tokuhashi, Yoshimichi Okayama
      Background Neural pathways are thought to be directly involved in the pathogenesis of rheumatoid arthritis (RA). Although synovial mast cells (MCs) are activated by substance P (SP), the role of MCs in neural pathways in RA remains unknown. The aims of this study were to investigate 1) whether tachykinins are produced by synovial MCs and whether production differs in RA and osteoarthritis (OA) patients, and 2) what is the responsible receptor for SP in synovial MCs. Methods Synovial tissues were obtained from patients with RA or OA undergoing joint replacement surgery. Cultured synovium-derived MCs were generated by culturing dispersed synovial cells with stem cell factor. SP expression was investigated using immunofluorescence and enzyme immunoassays. Mas-related gene X2 (MrgX2) expression was reduced in human MCs using a lentiviral shRNA silencing technique. Results SP expression was localized around the cell membrane in 41% (median) of the MCs in synovium from RA but in only 7% of that from OA, suggesting the activation of MCs. Synovial MCs expressed tachykinin (TAC) 1 mRNA, the expression of which was upregulated by the aggregation of FcɛRI or the addition of aggregated IgG. However, the released SP appeared to be rapidly degraded by MC chymase. Synovial MCs were activated with SP through MrgX2 to release histamine without producing proinflammatory cytokines. Conclusions Activated synovial MCs may rapidly degrade SP, which may downregulate the SP-mediated activation of synoviocytes in RA. On the other hand, SP activates MCs to induce inflammatory mediators, suggesting the dual regulation of SP-mediated inflammation by MCs in RA.

      PubDate: 2017-09-06T04:13:05Z
      DOI: 10.1016/j.alit.2017.03.002
       
  • Leukotriene receptor antagonist attenuated airway inflammation and
           hyperresponsiveness in a double-stranded RNA-induced asthma exacerbation
           model

    • Authors: Mariko Ujino; Naoya Sugimoto; Yuta Koizumi; Shoki Ro; Yasuhiro Kojima; Kamiyama-Hara Asae; Naomi Yamashita; Ken Ohta; Hiroyuki Nagase
      Abstract: Publication date: September 2017
      Source:Allergology International, Volume 66, Supplement
      Author(s): Mariko Ujino, Naoya Sugimoto, Yuta Koizumi, Shoki Ro, Yasuhiro Kojima, Kamiyama-Hara Asae, Naomi Yamashita, Ken Ohta, Hiroyuki Nagase
      Background Viral infections are the most common triggers of asthma exacerbation, but the key molecules involved in this process have not been fully identified. Although cysteinyl leukotrienes (cysLTs) have been postulated as the key mediators, their precise roles remain largely unclear. To investigate the roles of cysLTs in virus-induced asthma exacerbation, we developed a murine model using a viral double-stranded RNA analog, polyinosinic–polycytidylic acid (poly I:C), and analyzed the effect of leukotriene receptor antagonist (LTRA) administration. Methods A/J mice were immunized with ovalbumin (OVA) + alum (days 0, 28, 42, and 49), followed by intranasal challenge with OVA (phase 1: days 50–52) and poly I:C (phase 2: days 53–55). Montelukast was administered during poly I:C challenge (phase 2) in the reliever model or throughout the OVA and poly I:C challenges (phases 1 and 2) in the controller model. Airway responsiveness to acetylcholine chloride was assessed, and bronchoalveolar lavage (BAL) was performed on day 56. Results Administration of poly I:C to OVA-sensitized and -challenged mice increased the number of eosinophils and levels of IL-13, IL-9, CCL3, and CXCL1 in BAL fluid (BALF) and tended to increase airway responsiveness. Montelukast significantly attenuated the poly I:C-induced increase in the number of eosinophils and levels of IL-13, IL-9, and CCL3 in BALF and airway hyperresponsiveness in both the reliever and controller models. Conclusions This is the first report showing that LTRA functionally suppressed the pathophysiology of a virus-induced asthma exacerbation model, suggesting the importance of cysLTs as a potential treatment target.

      PubDate: 2017-09-06T04:13:05Z
      DOI: 10.1016/j.alit.2017.05.004
       
  • Disulfide-linked dimerization of the FcRγ chain is required for positive
           and negative regulation of mast cell activation via FcεRI

    • Authors: Satoshi Nunomura; Chisei Ra; Tadashi Terui; Yoshimichi Okayama
      Abstract: Publication date: September 2017
      Source:Allergology International, Volume 66, Supplement
      Author(s): Satoshi Nunomura, Chisei Ra, Tadashi Terui, Yoshimichi Okayama


      PubDate: 2017-09-06T04:13:05Z
      DOI: 10.1016/j.alit.2017.04.010
       
  • Dectin-1 plays a critical role in HDM-induced PGE2 production in
           macrophages

    • Authors: Takashi Ito; Koichi Hirose; Ayako Norimoto; Aiko Saku; Hiroshi Nakajima
      Abstract: Publication date: September 2017
      Source:Allergology International, Volume 66, Supplement
      Author(s): Takashi Ito, Koichi Hirose, Ayako Norimoto, Aiko Saku, Hiroshi Nakajima


      PubDate: 2017-09-06T04:13:05Z
      DOI: 10.1016/j.alit.2017.05.001
       
  • CpG oligodeoxynucleotides enhance airway epithelial barrier integrity

    • Authors: Yasuhiro Gon; Sotaro Shikano; Shuichiro Maruoka; Kenji Mizumura; Yutaka Kozu; Kazumichi Kuroda; Eriko Tsuboi; Ikuko Takeshita; Hiroyuki Kishi; Yasuyuki Nomura; Takeshi Oshima; Shu Hashimoto
      Abstract: Publication date: September 2017
      Source:Allergology International, Volume 66, Supplement
      Author(s): Yasuhiro Gon, Sotaro Shikano, Shuichiro Maruoka, Kenji Mizumura, Yutaka Kozu, Kazumichi Kuroda, Eriko Tsuboi, Ikuko Takeshita, Hiroyuki Kishi, Yasuyuki Nomura, Takeshi Oshima, Shu Hashimoto


      PubDate: 2017-09-06T04:13:05Z
      DOI: 10.1016/j.alit.2017.05.002
       
  • Involvement of apoptosis signal-regulating kinase-1 in house dust
           mite-induced allergic asthma in mice

    • Authors: Shuichiro Maruoka; Yasuhiro Gon; Kenji Mizumura; Shinichi Okamoto; Kota Tsuya; Sotaro Shikano; Kaori Soda; Isao Naguro; Hidenori Ichijo; Shu Hashimoto
      Abstract: Publication date: September 2017
      Source:Allergology International, Volume 66, Supplement
      Author(s): Shuichiro Maruoka, Yasuhiro Gon, Kenji Mizumura, Shinichi Okamoto, Kota Tsuya, Sotaro Shikano, Kaori Soda, Isao Naguro, Hidenori Ichijo, Shu Hashimoto


      PubDate: 2017-09-06T04:13:05Z
      DOI: 10.1016/j.alit.2017.05.007
       
  • Chronic spontaneous urticaria and the extrinsic coagulation system

    • Authors: Yuhki Yanase; Satoshi Morioke; Kazumasa Iwamoto; Shunsuke Takahagi; Kazue Uchida; Tomoko Kawaguchi; Kaori Ishii; Izumi Hide; Michihiro Hide
      Abstract: Publication date: Available online 6 October 2017
      Source:Allergology International
      Author(s): Yuhki Yanase, Shunsuke Takahagi, Michihiro Hide
      Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch. Recently, the activation of the blood coagulation cascade has been suggested to be involved in CSU, but the trigger of the coagulation cascade remains unclear. In this article, we review recent understanding of the relationship between the pathogenesis of CSU and extrinsic coagulation reactions. In CSU, vascular endothelial cells and eosinophils may play a role as TF-expressing cells for activating the extrinsic coagulation pathway. Moreover, the expression of TF on endothelial cells is synergistically enhanced by the activation of Toll-like receptors and histamine H1 receptors. The activated coagulation factors may induce plasma extravasation followed by degranulation of skin mast cells and edema formation recognized as wheal in CSU. Molecules involved in this cascade could be a target for new and more effective treatments of urticaria.

      PubDate: 2017-10-07T15:22:34Z
      DOI: 10.1016/j.jaci.2017.07.026
       
  • Airway inflammation phenotype prediction in asthma patients using lung
           sound analysis with fractional exhaled nitric oxide

    • Authors: Terufumi Shimoda; Yasushi Obase Yukio Nagasaka Hiroshi Nakano Reiko Kishikawa
      Abstract: Publication date: October 2017
      Source:Allergology International, Volume 66, Issue 4
      Author(s): Terufumi Shimoda, Yasushi Obase, Yukio Nagasaka, Hiroshi Nakano, Reiko Kishikawa, Tomoaki Iwanaga
      Background We previously reported the results of lung sound analysis in patients with bronchial asthma and demonstrated that the exhalation-to-inhalation sound pressure ratio in the low frequency range between 100 and 200 Hz (E/I LF) was correlated with the presence of airway inflammation and airway obstruction. We classified asthma patients by airway inflammation phenotype using the induced sputum eosinophil and neutrophil ratio and determined whether this phenotype could be predicted using E/I LF and fractional exhaled nitric oxide values. Methods Steroid-naive bronchial asthma patients were classified into four phenotypes, including “Low inflammation” (35 patients), “Eosinophilic type” (58 patients), “Neutrophilic type” (15 patients), and “Mixed type” (15 patients) based on the results of induced sputum examinations. The E/I LF data and FeNO levels were then evaluated for the four phenotype groups; the prediction powers of these two indices were then analyzed for each phenotype. Results The median E/I LF value was highest in the “Mixed type” and lowest in the “Low inflammation” group. FeNO differentiated between the “Low inflammation” and “Eosinophilic type” groups, “Low inflammation” and “Neutrophilic type” groups, and “Neutrophilic type” and “Mixed type” (p < 0.0001, p = 0.007, and p = 0.04, respectively). E/I LF differentiated between the “Low inflammation” and “Eosinophilic type” groups (p = 0.006). E/I LF could distinguish the “Mixed type” group from the “Low inflammation” and “Eosinophilic type” groups (p = 0.002). Conclusions A combination of the E/I LF value and FeNO may be useful for the classification of the airway inflammation phenotype in patients with bronchial asthma.

      PubDate: 2017-09-30T16:12:15Z
       
  • Therapeutic approaches of asthma and COPD overlap

    • Authors: Mitsuko Kondo; Jun Tamaoki
      Abstract: Publication date: Available online 29 September 2017
      Source:Allergology International
      Author(s): Mitsuko Kondo, Jun Tamaoki
      Asthma and COPD overlap (ACO) is an important clinical phenotype, due to the low-health-related quality of life (QOL), rapid decline in lung function, frequent exacerbation, and high economic burden. However, no large-scaled therapeutic trials of ACO have been conducted. At present, ACO is treated according to asthma/COPD guidelines. The goals of ACO treatment are to relieve symptoms and improve QOL and lung functions. Treatment must also prevent disease progression, airway remodeling, exacerbation, complications, and comorbidities. To achieve these goals, ACO needs first to be assessed based on pathophysiological findings. Comprehensive long-term management includes medication, reduction of risk factors, environmental improvement, patient education, rehabilitation, and vaccination. Drug treatment for ACO employs a combination of inhaled corticosteroids (ICSs) and long-acting bronchodilators; long-acting muscarinic antagonists and/or long-acting β2-agonists. The dose of ICS is determined according to ACO severity. Leukotriene receptor antagonists and theophylline are used as add-on drugs. Macrolides and expectorants are recommended for reduction of mucus hypersecretion. Anti-IgE and anti–IL-5 antibodies, oral corticosteroids, and oxygen therapy are additional treatments for the most severe ACO. The therapeutic effects are evaluated using lung function tests, eosinophil counts in sputum and blood, FeNO, and symptom questionnaires. ACO exacerbation is treated by inhalation of short-acting β2-agonist and systemic corticosteroids. The doses of corticosteroids are determined based on the asthma/COPD component of the exacerbation. Administration of antibiotics is recommended if sputum is purulent. Referral to specialists is necessary in cases of inability to control symptoms by medication, uncertain diagnosis with atypical features, or severe complications and comorbidities.

      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.09.002
       
  • A case of clinically amyopathic dermatomyositis that developed during
           anti-TNF-α therapy for rheumatoid arthritis

    • Authors: Miki Takata; Akira Yamasaki; Nanako Yamada; Hiroshi Hagino; Yoshihiro Funaki; Tomoya Harada; Ryota Okazaki; Yasuyuki Hasegawa; Takehito Fukushima; Masato Morita; Yuriko Sueda; Akihiro Yamamoto; Eiji Shimizu
      Abstract: Publication date: Available online 28 September 2017
      Source:Allergology International
      Author(s): Miki Takata, Akira Yamasaki, Nanako Yamada, Hiroshi Hagino, Yoshihiro Funaki, Tomoya Harada, Ryota Okazaki, Yasuyuki Hasegawa, Takehito Fukushima, Masato Morita, Yuriko Sueda, Akihiro Yamamoto, Eiji Shimizu


      PubDate: 2017-09-30T16:12:15Z
      DOI: 10.1016/j.alit.2017.09.001
       
  • Role of airway epithelial barrier dysfunction in pathogenesis of asthma

    • Authors: Yasuhiro Gon; Shu Hashimoto
      Abstract: Publication date: Available online 21 September 2017
      Source:Allergology International
      Author(s): Yasuhiro Gon, Shu Hashimoto
      Bronchial asthma is characterized by persistent cough, increased sputum, and repeated wheezing. The pathophysiology underlying these symptoms is the hyper-responsiveness of the airway along with chronic airway inflammation. Repeated injury, repair, and regeneration of the airway epithelium following exposure to environmental factors and inflammation results in histological changes and functional abnormalities in the airway mucosal epithelium; such changes are believed to have a significant association with the pathophysiology of asthma. Damage to the barrier functions of the airway epithelium enhances mucosal permeability of foreign substances in the airway epithelium of patients with asthma. Thus, epithelial barrier fragility is closely involved in releasing epithelial cytokines (e.g., TSLP, IL-25, and IL-33) because of the activation of airway epithelial cells, dendritic cells, and innate group 2 innate lymphoid cells (ILC2). Functional abnormalities of the airway epithelial cells along with the activation of dendritic cells, Th2 cells, and ILC2 form a single immunopathological unit that is considered to cause allergic airway inflammation. Here we use the latest published literature to discuss the potential pathological mechanisms regarding the onset and progressive severity of asthma with regard to the disruption of the airway epithelial function.

      PubDate: 2017-09-24T04:28:02Z
      DOI: 10.1016/j.alit.2017.08.011
       
  • Vitamin D deficiency exacerbates sensitization and allergic diarrhea in a
           murine food allergy model

    • Authors: Teruaki Matsui; Hirotaka Yamashita; Ken-ichi Saneyasu; Hiroyuki Tanaka; Komei Ito; Naoki Inagaki
      Abstract: Publication date: Available online 19 September 2017
      Source:Allergology International
      Author(s): Teruaki Matsui, Hirotaka Yamashita, Ken-ichi Saneyasu, Hiroyuki Tanaka, Komei Ito, Naoki Inagaki


      PubDate: 2017-09-24T04:28:02Z
      DOI: 10.1016/j.alit.2017.08.010
       
  • Long-term course of serum total and free IgE levels in severe asthma
           patients treated with omalizumab

    • Authors: Yasuhiro Gon; Reiko Ito; Shuichiro Maruoka; Kenji Mizumura; Yutaka Kozu; Hisato Hiranuma; Yuko Iida; Mari Hikichi; Sotaro Shikano; Shu Hashimoto
      Abstract: Publication date: Available online 18 September 2017
      Source:Allergology International
      Author(s): Yasuhiro Gon, Reiko Ito, Shuichiro Maruoka, Kenji Mizumura, Yutaka Kozu, Hisato Hiranuma, Yuko Iida, Mari Hikichi, Sotaro Shikano, Shu Hashimoto


      PubDate: 2017-09-24T04:28:02Z
      DOI: 10.1016/j.alit.2017.08.003
       
  • Mast cells derived from human induced pluripotent stem cells are useful
           for allergen tests

    • Authors: Akira Igarashi; Yasuhiro Ebihara; Tomoaki Kumagai; Hiroyuki Hirai; Kinya Nagata; Kohichiro Tsuji
      Abstract: Publication date: Available online 14 September 2017
      Source:Allergology International
      Author(s): Akira Igarashi, Yasuhiro Ebihara, Tomoaki Kumagai, Hiroyuki Hirai, Kinya Nagata, Kohichiro Tsuji
      Background Several methods have been developed to detect allergen-specific IgE in sera. The passive IgE sensitization assay using human IgE receptor-expressing rat cell line RBL-2H3 is a powerful tool to detect biologically active allergen-specific IgE in serum samples. However, one disadvantage is that RBL-2H3 cells are vulnerable to high concentrations of human sera. Only a few human cultured cell lines are easily applicable to the passive IgE sensitization assay. However, the use of human induced pluripotent stem cells (iPSCs) to generate human mast cells (MCs) has not yet been reported. Methods The nuclear factor-kappa B (NF-κB)-responsive luciferase reporter gene was stably introduced into a human iPSC line 201B7, and the transfectants were induced to differentiate into MCs (iPSC-MCs). The iPSC-MCs were sensitized overnight with sera from subjects who were allergic to cedar pollen, ragweed pollen, mites, or house dust, and then stimulated with an extract of corresponding allergens. Activation of iPSC-MCs was evaluated by β-hexosaminidase release, histamine release, or luciferase intensity. Results iPSCs-MCs stably expressed high-affinity IgE receptor and functionally responded to various allergens when sensitized with human sera from relevant allergic subjects. This passive IgE sensitization system, which we termed the induced mast cell activation test (iMAT), worked well even with undiluted human sera. Conclusions iMAT may serve as a novel determining system for IgE/allergens in the clinical and research settings.

      PubDate: 2017-09-19T04:23:41Z
      DOI: 10.1016/j.alit.2017.08.008
       
  • Surveillance of the use of adrenaline auto-injectors in Japanese children

    • Authors: Komei Ito; Manabu Ono; Naoyuki Kando; Teruaki Matsui; Tomoko Nakagawa; Shiro Sugiura; Motohiro Ebisawa
      Abstract: Publication date: Available online 4 August 2017
      Source:Allergology International
      Author(s): Komei Ito, Manabu Ono, Naoyuki Kando, Teruaki Matsui, Tomoko Nakagawa, Shiro Sugiura, Motohiro Ebisawa
      Background The appropriate usage of an adrenaline auto-injector (AAI, Epipen®) is a key aspect of patient and social education in the management of anaphylaxis. However, although AAIs are being prescribed increasingly frequently, there are few reports on their actual use. Methods The Anaphylaxis Working Group of the Japanese Society of Pediatric Allergy and Clinical Immunology requested that society members register cases in which AAIs were used. Two hundred and sixty-six cases were collected from March 2014 to March 2016. Results The cases included 240 events of immediate-type food allergies caused by cow's milk (n = 100), hen's egg (n = 42), wheat (n = 40), and peanuts (n = 11). Exercise-related events were reported in 19 cases; however, the diagnosis of food-dependent exercise-induced anaphylaxis with a specific causative food was only made in 4 cases (wheat, n = 2; fish, n = 1; squid, n = 1). The frequent reasons for the causative intake included programmed intake (n = 48), failure to check the food labeling (n = 43), and consuming an inappropriate food (n = 26). AAIs were used at schools or nurseries in 67 cases, with school or nursery staff members administering the AAI in 39 cases (58%). On arriving at the hospital, the symptom grade was improved in 71% of the cases, while grade 4 symptoms remained in 20% of the cases. No lethal cases or sequelae were reported. Conclusions AAIs were used effectively, even by school teachers. The need to visit a hospital after the use of an AAI should be emphasized because additional treatment might be required.

      PubDate: 2017-09-19T04:23:41Z
      DOI: 10.1016/j.alit.2017.07.002
       
  • Mucus plugging in allergic bronchopulmonary aspergillosis: Implication of
           the eosinophil DNA traps

    • Authors: Ayumi Omokawa; Shigeharu Ueki; Yuta Kikuchi; Masahide Takeda; Mariko Asano; Kazuhiro Sato; Masaaki Sano; Hiroshi Ito; Makoto Hirokawa
      Abstract: Publication date: Available online 5 September 2017
      Source:Allergology International
      Author(s): Ayumi Omokawa, Shigeharu Ueki, Yuta Kikuchi, Masahide Takeda, Mariko Asano, Kazuhiro Sato, Masaaki Sano, Hiroshi Ito, Makoto Hirokawa


      PubDate: 2017-09-06T04:13:05Z
      DOI: 10.1016/j.alit.2017.08.002
       
  • Exposure amount and timing of solar irradiation during pregnancy and the
           risk of sensitization in children

    • Authors: Hyun Yong Koh; Eunhae Cho; So-Yeon Lee; Woo Kyung Kim; Yong Mean Park; Jihyun Kim; Kangmo Ahn; Seung Won Lee; Mi Ae Kim; Myung-Il Hahm; Yoomi Chae; Kee-Jae Lee; Ho-Jang Kwon; Man Yong Han
      Abstract: Publication date: Available online 4 September 2017
      Source:Allergology International
      Author(s): Hyun Yong Koh, Eunhae Cho, So-Yeon Lee, Woo Kyung Kim, Yong Mean Park, Jihyun Kim, Kangmo Ahn, Seung Won Lee, Mi Ae Kim, Myung-Il Hahm, Yoomi Chae, Kee-Jae Lee, Ho-Jang Kwon, Man Yong Han
      Background Solar irradiation affects sensitization to aeroallergens and the prevalence of allergic diseases. Little is known, however, about how the time and amount of solar irradiation during pregnancy affects such risks in children. We aimed to find out how solar irradiation during pregnancy affects sensitization to aero-allergens and the prevalence of allergic diseases in children. Methods This population-based cross-sectional study involved 7301 aged 6 years and aged 12 years children. Maternal exposure to solar irradiation during pregnancy was evaluated using data from weather stations closest to each child's birthplace. Monthly average solar irradiation during the second and third trimesters was calculated with rank by quartiles. Risks of allergic sensitization and allergic disease were estimated. Results Relative to the first (lowest) quartile, the adjusted odds ratio (aOR) for allergic sensitization in the fourth (highest) quartile was lowest within solar irradiation during pregnancy months 5–6 (aOR = 0.823, 95% CI 0.720–0.942, p < 0.05). During months 9–10, the aOR for allergic sensitization for the fourth was higher than the first quartile of solar irradiation (aOR = 1.167, 95% CI 1.022–1.333, p < 0.05). Similar results were observed when solar irradiation was analyzed as a continuous variable during months 5 (aOR = 0.975, 95% CI 0.962–0.989, p < 0.001) and month 9 (aOR = 1.018, 95% CI 1.004–1.031, p = 0.003). Increased solar irradiation during months 7–8 increased the risk of asthma (aOR = 1.309, 95% CI 1.024–1.674, p = 0.032). Conclusions Maternal exposure to solar irradiation during the second trimester of pregnancy associated with reduced aeroallergen sensitization, whereas solar irradiation during the third trimester was related to increased sensitization to aeroallergens.

      PubDate: 2017-09-06T04:13:05Z
      DOI: 10.1016/j.alit.2017.08.007
       
  • Role of the microbiota in skin immunity and atopic dermatitis

    • Authors: Yuriko Yamazaki; Yuumi Nakamura; Gabriel Núñez
      Abstract: Publication date: Available online 4 September 2017
      Source:Allergology International
      Author(s): Yuriko Yamazaki, Yuumi Nakamura, Gabriel Núñez
      Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 15–20% of children and 2–5% of adults in industrialized countries. The pathogen Staphylococcus aureus selectively colonizes the lesional skin of AD patients while this bacterium is absent in the skin of the majority of healthy individuals. However, the role of S. aureus in the pathogenesis of AD remains poorly understood. In addition to S. aureus, recent studies show a contribution of the skin microbiota to the regulation of immune responses in the skin as well as to the development of inflammatory skin disease. This review summarizes current knowledge about the role of the microbiota in skin immune responses and the role of S. aureus virulent factors in the pathogenesis of AD.

      PubDate: 2017-09-06T04:13:05Z
      DOI: 10.1016/j.alit.2017.08.004
       
  • Hand eczema as a risk factor for food allergy among occupational kitchen
           workers

    • Authors: Takafumi Minami; Yuma Fukutomi; Kiyoshi Sekiya; Akira Akasawa; Masami Taniguchi
      Abstract: Publication date: Available online 2 September 2017
      Source:Allergology International
      Author(s): Takafumi Minami, Yuma Fukutomi, Kiyoshi Sekiya, Akira Akasawa, Masami Taniguchi
      Background An increasing number of studies in children is highlighting the importance of transdermal routes of exposure to food allergens through damaged skin in the pathogenesis of food allergies. However, data on this in adults are limited. A few case-series studies has documented development of food allergy among kitchen workers with hand eczema after direct contact exposure to foods. Methods To explore the significance of hand eczema as a risk factor for food allergies in adults at the epidemiological level, we performed a cross-sectional web-based questionnaire survey on kitchen workers whose exposures were classed as occupational (cooks and food handlers, n = 1592) or non-occupational (housewives, n = 1915). Logistic regression was used to explore the association between the presence/severity of hand eczema and the risk of food allergy after adjustment for potential confounders. Results Current hand eczema and current diagnosed food allergy were more common among occupational kitchen workers (OKW) than among non-occupational kitchen workers (NOKW) (32.3%-vs-29.9% and 9.9%-vs-3.8%, respectively). Current hand eczema was significantly associated with increased risk of current diagnosed food allergy in OKW (adjusted odds ratio 2.4, 95% CI 1.6–3.7). Those with more severe hand eczema were more likely to suffer from allergic symptoms for foods, and diagnosed food allergy. Conclusions This study illustrates a significant public health problem in the adult population, documenting a major impact of hand eczema on the ongoing adult food allergy epidemic.

      PubDate: 2017-09-06T04:13:05Z
      DOI: 10.1016/j.alit.2017.08.005
       
  • Bugging allergy; role of pre-, pro- and synbiotics in allergy prevention

    • Authors: Christina E. West; Majda Dzidic; Susan L. Prescott; Maria C. Jenmalm
      Abstract: Publication date: Available online 1 September 2017
      Source:Allergology International
      Author(s): Christina E. West, Majda Dzidic, Susan L. Prescott, Maria C. Jenmalm
      Large-scale biodiversity loss and complex changes in social behaviors are altering human microbial ecology. This is increasingly implicated in the global rise in inflammatory diseases, most notably the “allergy epidemic” in very early life. Colonization of human ecological niches, particularly the gastrointestinal tract, is critical for normal local and systemic immune development and regulation. Disturbances in composition, diversity and timing of microbial colonization have been associated with increased allergy risk, indicating the importance of strategies to restore a dysbiotic gut microbiota in the primary prevention of allergic diseases, including the administration of probiotics, prebiotics and synbiotics. Here, we summarize and discuss findings of randomized clinical trials that have examined the effects of these microbiome-related strategies on short and long-term allergy preventative effects – including new guidelines from the World Allergy Organization which now recommend probiotics and prebiotics for allergy prevention under certain conditions. The relatively low quality evidence, limited comparative studies and large heterogeneity between studies, have collectively hampered recommendations on specific probiotic strains, specific timing and specific conditions for the most effective preventive management. At the same time the risk of using available products is low. While further research is needed before specific practice guidelines on supplement probiotics and prebiotics, it is equally important that the underlying dietary and lifestyle factors of dysbiosis are addressed at both the individual and societal levels.

      PubDate: 2017-09-06T04:13:05Z
      DOI: 10.1016/j.alit.2017.08.001
       
  • Development of a questionnaire to evaluate asthma control in Japanese
           asthma patients

    • Authors: Yuji Tohda; Soichiro Hozawa; Hiroshi Tanaka
      Abstract: Publication date: Available online 1 September 2017
      Source:Allergology International
      Author(s): Yuji Tohda, Soichiro Hozawa, Hiroshi Tanaka
      Background The asthma control questionnaires used in Japan are Japanese translations of those developed outside Japan, and have some limitations; a questionnaire designed to optimally evaluate asthma control levels for Japanese may be necessary. The present study was conducted to validate the Japan Asthma Control Survey (JACS) questionnaire in Japanese asthma patients. Methods A total of 226 adult patients with mild to severe persistent asthma were enrolled and responded to the JACS questionnaire, asthma control questionnaire (ACQ), and Mini asthma quality of life questionnaire (Mini AQLQ) at Weeks 0 and 4. The reliability, validity, and sensitivity/responsiveness of the JACS questionnaire were evaluated. Results The intra-class correlation coefficients (ICCs) were within the range of 0.55–0.75 for all JACS scores, indicating moderate/substantial reproducibility. For internal consistency, Cronbach's alpha coefficients ranged from 0.76 to 0.92 in total and subscale scores, which were greater than the lower limit of internal consistency. As for factor validity, the cumulative contribution ratio of four main factors was 0.66. For criterion-related validity, the correlation coefficients between the JACS total score and ACQ5, ACQ6, and Mini AQLQ scores were −0.78, −0.78, and 0.77, respectively, showing a significant correlation (p < 0.0001). Conclusions The JACS questionnaire was validated in terms of reliability and validity. It will be necessary to evaluate the therapeutic efficacy measured by the JACS questionnaire and calculate cutoff values for the asthma control status in a higher number of patients. Clinical Trial registration UMIN000016589

      PubDate: 2017-09-06T04:13:05Z
      DOI: 10.1016/j.alit.2017.06.013
       
  • Urticaria by thiamine (vitamin B1)

    • Authors: Ana Rodríguez-Fernández; Marcos Sánchez-Domínguez; Blanca Noguerado-Mellado; Patricia Rojas-Pérez-Ezquerra
      Abstract: Publication date: Available online 23 August 2017
      Source:Allergology International
      Author(s): Ana Rodríguez-Fernández, Marcos Sánchez-Domínguez, Blanca Noguerado-Mellado, Patricia Rojas-Pérez-Ezquerra


      PubDate: 2017-08-31T04:08:12Z
      DOI: 10.1016/j.alit.2017.07.008
       
  • Development of the gut microbiota in infancy and its impact on health in
           later life

    • Authors: Masaru Tanaka; Jiro Nakayama
      Abstract: Publication date: Available online 18 August 2017
      Source:Allergology International
      Author(s): Masaru Tanaka, Jiro Nakayama
      Gut microbial ecology and function are dynamic in infancy, but are stabilized in childhood. The ‘new friends’ have a great impact on the development of the digestive tract and host immune system. In the first year of life, especially, the gut microbiota dramatically changes through interactions with the developing immune system in the gut. The process of establishing the gut microbiota is affected by various environmental factors, with the potential to be a main determinant of life-long health. In this review, we summarize recent findings regarding gut microbiota establishment, including the importance of various factors related to the development of the immune system and allergic diseases later in life.

      PubDate: 2017-08-21T04:00:18Z
      DOI: 10.1016/j.alit.2017.07.010
       
  • Omalizumab for hypersensitive reaction to seminal plasma: A case report

    • Authors: Maria Teresa Burguete-Cabanas; Oscar R. Fajardo-Ramirez; Roberta Yesaki; Raul Estrada-Maganas; Sandra Salazar-Meza; Olga Rios-Chavez; Irene Meester; Julio C. Salas-Alanis
      Abstract: Publication date: Available online 15 August 2017
      Source:Allergology International
      Author(s): Maria Teresa Burguete-Cabanas, Oscar R. Fajardo-Ramirez, Roberta Yesaki, Raul Estrada-Maganas, Sandra Salazar-Meza, Olga Rios-Chavez, Irene Meester, Julio C. Salas-Alanis


      PubDate: 2017-08-21T04:00:18Z
      DOI: 10.1016/j.alit.2017.07.009
       
  • Desensitization to a whole egg by rush oral immunotherapy improves the
           quality of life of guardians: A multicenter, randomized, parallel-group,
           delayed-start design study

    • Authors: Naoka Itoh-Nagato; Yuzaburo Inoue; Mizuho Nagao; Takao Fujisawa; Naoki Shimojo; Tsutomu Iwata; Yuichi Adachi; Koichi Arakawa; Takayasu Arima; Keitaro Fukushima; Akira Hoshioka; Takashi Igarashi; Toshiko Itazawa; Komei Itoh; Makoto Kameda; Naoyuki Kando; Izumi Kato; Taeru Kitabayashi; Takae Kobayashi; Harumi Koyama; Yoshinori Morita; Taiji Nakano; Shuichi Suzuki; Yuri Takaoka; Minako Tomiita; Hisako Yagi; Yuko Yajima; Akiko Yamaide; Masahiro Yasui; Shigemi Yoshihara
      Abstract: Publication date: Available online 1 August 2017
      Source:Allergology International
      Author(s): Naoka Itoh-Nagato, Yuzaburo Inoue, Mizuho Nagao, Takao Fujisawa, Naoki Shimojo, Tsutomu Iwata
      Background Patients with food allergies and their families have a significantly reduced health-related quality of life (QOL). Methods We performed a multicenter, randomized, parallel-group, delayed-start design study to clarify the efficacy and safety of rush oral immunotherapy (rOIT) and its impact on the participants' daily life and their guardians (UMIN000003943). Forty-five participants were randomly divided into an early-start group and a late-start group. The early-start group received rOIT for 3 months, while the late-start group continued the egg elimination diet (control). In the next stage, both groups received OIT until all participants had finished 12 months of maintenance OIT. Results The ratio of the participants in whom an increase of the TD was achieved in the first stage was significantly higher in the early-start group (87.0%), than in the late-start group (22.7%). The QOL of the guardians in the early-start group significantly improved after the first stage (65.2%), in comparison to the late-start group (31.8%). During 12 months of rOIT, the serum ovomucoid-specific IgE levels, the percentage of CD203c+ basophils upon stimulation with egg white, and the wheal size to egg white were decreased, while the serum ovomucoid-specific IgG4 levels were increased. However, approximately 80% of the participants in the early-start group showed an allergic reaction during the first stage of the study, whereas none of the patients in the late-start group experienced an allergic reaction. Conclusions rOIT induced desensitization to egg and thus improved the QOL of guardians; however, the participants experienced frequent allergic reactions due to the treatment.

      PubDate: 2017-08-11T03:51:54Z
      DOI: 10.1016/j.alit.2017.07.007
       
  • Th9 cells induce steroid-resistant bronchial hyperresponsiveness in mice

    • Authors: Mayumi Saeki; Osamu Kaminuma; Tomoe Nishimura; Noriko Kitamura; Akio Mori; Takachika Hiroi
      Abstract: Publication date: Available online 26 July 2017
      Source:Allergology International
      Author(s): Mayumi Saeki, Osamu Kaminuma, Tomoe Nishimura, Noriko Kitamura, Akio Mori, Takachika Hiroi
      Background Reduced responsiveness to corticosteroid therapy is a major problem for patients with severe asthma. Although Th9 cells, along with Th2 cells, facilitate antigen-induced airway eosinophilia and bronchial hyperresponsiveness (BHR), the sensitivity of Th9 cell-mediated responses to steroid therapy remains unknown. In this study, we investigated the effect of dexamethasone (Dex) on antigen-induced airway inflammation in Th9 cell-transferred mice. Methods Ovalbumin (OVA)-specific Th2 and Th9 cells were polarized from the CD4+ T cells of DO11.10/RAG-2 −/− mice. BALB/c mice were adoptively transferred with Th2 or Th9 cells and challenged with OVA. Dex treatment was performed twice, at 1 h before and at 24 h after the OVA challenge. Following treatment, the number of inflammatory cells in the bronchoalveolar lavage fluid and the bronchial responsiveness to inhaled methacholine were determined. Results In both the Th2 and Th9 cell-transferred mice, substantial accumulation of eosinophils in the lungs and BHR were induced by challenge with the specific antigen. In the Th2 cell-transferred mice, these responses were significantly diminished by Dex treatment. In contrast, neither cellular infiltration nor BHR was affected by Dex treatment in the Th9 cell-transferred mice, although the Th9 cells substantially expressed glucocorticoid receptor α. Accordingly, antigen-induced interleukin-9 expression in the Th9 cells was attenuated by Dex treatment at least in vitro. Antigen-induced lung infiltration of infused Th2 cells but not Th9 cells was significantly suppressed by Dex. Conclusions In contrast to Th2-mediated responses, Th9-mediated airway inflammation was not affected by Dex. Th9 cells might be involved in the developmental mechanisms of steroid-resistant asthma.

      PubDate: 2017-08-01T03:43:37Z
      DOI: 10.1016/j.alit.2017.07.001
       
  • Resveratrol inhibits IgE binding and down-regulates intracellular
           phosphorylation of Syk following IgE aggregation on human basophils

    • Authors: Sayaka Arakawa; Maho Suzukawa; Sayaka Igarashi; Hirotoshi Matsui; Masao Yamaguchi; Takahide Nagase; Ken Ohta
      Abstract: Publication date: Available online 14 July 2017
      Source:Allergology International
      Author(s): Sayaka Arakawa, Maho Suzukawa, Sayaka Igarashi, Hirotoshi Matsui, Masao Yamaguchi, Takahide Nagase, Ken Ohta


      PubDate: 2017-07-15T03:31:41Z
      DOI: 10.1016/j.alit.2017.06.015
       
  • Epithelial-mesenchymal transition of human lung adenocarcinoma A549 cells
           up-regulates cytokine production upon LPS stimulation

    • Authors: Takafumi Kato; Koichi Kobayashi; Maho Suzukawa; Minako Saito; Kenichi Okuda; Kazuya Koyama; Sayaka Igarashi; Sayaka Arakawa; Nobuharu Ohshima; Hirotoshi Matsui; Takahide Nagase; Ken Ohta
      Abstract: Publication date: Available online 13 July 2017
      Source:Allergology International
      Author(s): Takafumi Kato, Koichi Kobayashi, Maho Suzukawa, Minako Saito, Kenichi Okuda, Kazuya Koyama, Sayaka Igarashi, Sayaka Arakawa, Nobuharu Ohshima, Hirotoshi Matsui, Takahide Nagase, Ken Ohta


      PubDate: 2017-07-15T03:31:41Z
      DOI: 10.1016/j.alit.2017.06.014
       
  • Elevated uric acid and adenosine triphosphate concentrations in
           bronchoalveolar lavage fluid of eosinophilic pneumonia

    • Authors: Takehito Kobayashi; Kazuyuki Nakagome; Toru Noguchi; Kiyoko Kobayashi; Yutaka Ueda; Tomoyuki Soma; Kenji Ikebuchi; Hidetomo Nakamoto; Makoto Nagata
      Abstract: Publication date: Available online 10 July 2017
      Source:Allergology International
      Author(s): Takehito Kobayashi, Kazuyuki Nakagome, Toru Noguchi, Kiyoko Kobayashi, Yutaka Ueda, Tomoyuki Soma, Kenji Ikebuchi, Hidetomo Nakamoto, Makoto Nagata
      Background Recent evidence has suggested that the innate immune response may play a role in the development of eosinophilic airway inflammation. We previously reported that uric acid (UA) and adenosine triphosphate (ATP), two important damage-associated molecular pattern molecules (DAMPs), activate eosinophil functions, suggesting that these molecules may be involved in the development of eosinophilic airway inflammation. The objective of this study was to measure the concentrations of DAMPs including UA and ATP in the bronchoalveolar lavage fluid (BALF) of patients with eosinophilic pneumonia (EP). Methods BAL was performed in patients with EP including acute and chronic eosinophilic pneumonia, and in patients with hypersensitivity pneumonia, and sarcoidosis. UA, ATP, and cytokine concentrations in the BALF were then measured. Results The UA concentration was increased in the BALF of EP patients. UA concentrations correlated with eosinophil numbers, and with eosinophil-derived neurotoxin and interleukin (IL)-5 concentrations. Furthermore, the ATP concentration was increased in the BALF of EP patients and ATP concentrations correlated with UA concentrations. Moreover, IL-33 was increased in EP patients and IL-33 concentrations correlated with UA and ATP concentrations. Conclusions The UA and ATP concentration was increased in the BALF of EP patients. UA concentrations correlated with eosinophil numbers, and with ATP and IL-33 concentrations. Our findings suggest that DAMPs such as UA and ATP play a role in the pathogenesis of EP.

      PubDate: 2017-07-15T03:31:41Z
      DOI: 10.1016/j.alit.2017.06.010
       
  • Gut microbiome, metabolome, and allergic diseases

    • Authors: So-ichiro Hirata; Jun Kunisawa
      Abstract: Publication date: Available online 8 July 2017
      Source:Allergology International
      Author(s): So-ichiro Hirata, Jun Kunisawa
      The number of patients with allergic and inflammatory disorders has been increasing during the past several decades. Accumulating evidence has refined our understanding of the relationship between allergic diseases and the gut microbiome. In addition, the gut microbiome is now known to produce both useful and harmful metabolites from dietary materials. These metabolites and bacterial components help to regulate host immune responses and potentially affect the development of allergic diseases. Here, we describe recent findings regarding the immunologic crosstalk between commensal bacteria and dietary components in the regulation of host immunity and the influence of this relationship on the development of allergic diseases.

      PubDate: 2017-07-15T03:31:41Z
      DOI: 10.1016/j.alit.2017.06.008
       
 
 
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