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Publisher: Elsevier   (Total: 3049 journals)

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Showing 1 - 200 of 3089 Journals sorted alphabetically
A Practical Logic of Cognitive Systems     Full-text available via subscription   (Followers: 7)
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 25, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 22, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 86, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 25, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 30, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 4)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 5, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 363, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 3)
Acta Biomaterialia     Hybrid Journal   (Followers: 25, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 1)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
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Acta Oecologica     Hybrid Journal   (Followers: 10, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription   (Followers: 1)
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Acta Pharmaceutica Sinica B     Open Access   (Followers: 1)
Acta Poética     Open Access   (Followers: 4)
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Acta Sociológica     Open Access  
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Acta Urológica Portuguesa     Open Access  
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Acupuncture and Related Therapies     Hybrid Journal   (Followers: 4)
Acute Pain     Full-text available via subscription   (Followers: 13)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 6)
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Additives for Polymers     Full-text available via subscription   (Followers: 21)
Advanced Cement Based Materials     Full-text available via subscription   (Followers: 3)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 132, SJR: 5.2, h-index: 222)
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Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
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Advances in Engineering Software     Hybrid Journal   (Followers: 26, SJR: 0.486, h-index: 10)
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Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 43, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 3)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 51, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 16)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 22, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 0.497, h-index: 31)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 26)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 36, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 3, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 4)
Advances in Life Course Research     Hybrid Journal   (Followers: 8, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 2)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Marine Biology     Full-text available via subscription   (Followers: 16, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 22)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 10)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 8, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 4)
Advances in Oncobiology     Full-text available via subscription   (Followers: 3)
Advances in Organ Biology     Full-text available via subscription   (Followers: 2)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 24, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 13)
Advances in Pharmacology     Full-text available via subscription   (Followers: 15, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 4)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 17)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 62)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 2, SJR: 0.1, h-index: 2)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 5)
Advances in Space Research     Full-text available via subscription   (Followers: 360, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 8)
Advances in Surgery     Full-text available via subscription   (Followers: 7, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 30, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 16)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 44, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 5, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 330, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 5, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 8, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 417, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 16, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 30, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 40, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access  
Agriculture and Natural Resources     Open Access   (Followers: 2)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 55, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 5, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 11, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 8)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access   (Followers: 1)
Algal Research     Partially Free   (Followers: 8, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 4, SJR: 0.776, h-index: 35)
Alpha Omegan     Full-text available via subscription   (SJR: 0.121, h-index: 9)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 9, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 46, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 4)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 4)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 5)
American Heart J.     Hybrid Journal   (Followers: 49, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 48, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 40, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 9, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 32, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 26, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 32, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 46, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 200, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 59, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 6)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 25, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 27, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 25, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 35, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 6)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 58, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 12)
Anales de Cirugia Vascular     Full-text available via subscription  
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Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 4, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 37, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 166, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 8, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 12)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 1)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 22, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access  

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Journal Cover Alergologia Polska : Polish Journal of Allergology
  [1 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 2353-3854
   Published by Elsevier Homepage  [3049 journals]
  • Od Redaktora Naczelnego
    • Authors: Rafał Pawliczak
      First page: 45
      Abstract: Publication date: Available online 14 September 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Rafał Pawliczak


      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2017.06.003
      Issue No: Vol. 4, No. 2 (2017)
       
  • Od Redaktora Naczelnego
    • Authors: Rafał Pawliczak
      First page: 1
      Abstract: Publication date: Available online 16 June 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Rafał Pawliczak


      PubDate: 2017-06-20T06:49:31Z
      DOI: 10.1016/j.alergo.2017.03.001
      Issue No: Vol. 4, No. 1 (2017)
       
  • Wpływ spożywania orzeszków ziemnych w badaniu LEAP: wykonalność,
           rozwój fizyczny i stan odżywienia
    • Authors: Mary Feeney; George Du Toit; Graham Roberts; Peter H. Sayre; Kaitie Lawson; Henry T. Bahnson; Michelle L. Sever; Suzana Radulovic; Marshall Plaut; Gideon Lack
      Abstract: Publication date: October–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Issue 4
      Author(s): Mary Feeney, George Du Toit, Graham Roberts, Peter H. Sayre, Kaitie Lawson, Henry T. Bahnson, Michelle L. Sever, Suzana Radulovic, Marshall Plaut, Gideon Lack
      Graphical abstract image

      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2016.11.006
       
  • Omalizumab – standard terapii w astmie ciężkiej, przyszłość terapii
           w przewlekłej pokrzywce
    • Authors: Rafał Pawliczak
      Pages: 124 - 126
      Abstract: Publication date: October–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Issue 4
      Author(s): Rafał Pawliczak
      Omalizumab was introduced in the therapy regime of severe asthma treatment more than a decade ago. Nowadays, it is considered the gold standard to treat severe, allergic asthma. It allows patients to live normal, productive life, with significantly reduced number of asthma exacerbations, fewer parenteral glucocorticosteroid pulses, and reduced episodes of hospitalizations. Moreover, it is successfully employed in chronic urticaria treatment. In this short review, we summarize the importance of severe asthma diagnosis, the role of omalizumab in treatment of severe asthma, and the mechanism of action of omalizumab. The mechanism of action of omalizumab in chronic urticaria treatment remains to be fully elucidated. This paper is an introduction to the case series presented in this supplement.

      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2016.11.005
       
  • Effectiveness of omalizumab therapy in patients with highly severe
           allergic asthma treated in Department of Pulmonology in Krakow
    • Authors: Agnieszka Gawlewicz-Mroczka; Weronika Zastrzeżyńska; Marek Przybyszowski; Adam Ćmiel; Krzysztof Sładek
      Pages: 127 - 133
      Abstract: Publication date: October–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Issue 4
      Author(s): Agnieszka Gawlewicz-Mroczka, Weronika Zastrzeżyńska, Marek Przybyszowski, Adam Ćmiel, Krzysztof Sładek
      Immunoglobulin E plays an important role in allergic diseases. In patients with allergic asthma, exposure to allergens releases a wide range of proinflamatory mediators, which are responsible for acute and chronic symptoms of the disease. IgE has become an attractive target in allergic asthma. In 2006, in Europe omalizumab became available. Objectives Our knowledge of who will derive the highest benefit from omalizumab therapy is still limited. The aim of this study was to evaluate the efficacy of omalizumab during one year of therapy carried out under real-life conditions in Polish patients with severe allergic asthma. We also attempted to identify predictors for very good responses to treatment. Methods We enrolled 15 patients due to inclusion criteria of the program for severe allergic asthma funded by the National Health Insurance. All the patients were assessed for asthma control, quality of life, daily dose of oral and inhaled corticosteroids, asthma exacerbation rate, and lung function. The effectiveness of the treatment was analyzed after 16 weeks and one year following the inclusion each patient to the therapy. The patients were divided into two groups according to their response to the treatment: very good and good, based on the GETE scale. Results Omalizumab decreased the severity of symptoms, improved asthma control and quality of life in patients. It helped to reduce episodes of asthma exacerbation and the use of systemic corticosteroids. At present, the overall assessment by physicians is still the best and most reliable method of identifying responders to the omalizumab therapy.

      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2016.11.010
       
  • Nadwrażliwość na diazepam (Relanium)
    • Authors: Michał Abramowicz; Jerzy Kruszewski
      Pages: 134 - 136
      Abstract: Publication date: October–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Issue 4
      Author(s): Michał Abramowicz, Jerzy Kruszewski
      Diazepam – a benzodiazepine derivative is a quite commonly administered drug. Despite a fairly long list of diazepam's common side effects, hypersensitivity to this drug including anaphylactic shock almost does not occur. The paper presents a case of 60-year-old patient after a documented anaphylactic shock. The suggested cause was an intravenous administration of diazepam during the induction of anesthesia for the planned surgery. During the hospitalization, hypersensitivity to diazepam was confirmed by positive reactions in intradermal tests with diazepam.

      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2016.11.007
       
  • Zespół alergii jamy ustnej (zespół pyłkowo-pokarmowy), anafilaksja i
           alergologia molekularna. Nowe endotypy, nowe horyzonty
    • Authors: Łukasz Błażowski; Katarzyna Gregorczyk-Maślanka; Ryszard Kurzawa
      Pages: 137 - 143
      Abstract: Publication date: October–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Issue 4
      Author(s): Łukasz Błażowski, Katarzyna Gregorczyk-Maślanka, Ryszard Kurzawa
      The main symptoms of oral allergy syndrome (OAS) usually involve oral cavity, but in the case of pollen food syndrome (PFS), symptoms may lead to development of systemic reactions. Precise diagnostics of primary sensitizer and symptoms trigger allow to give proper recommendations for the patient, which are crucial for diminishing the risk of anaphylaxis. Based on the case of a 12-year-old patient, the rules of component-resolved diagnostics and the benefits of PFS endotypes identification were discussed.

      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2016.11.008
       
  • Od Redaktora Naczelnego
    • Authors: Rafał Pawliczak
      First page: 1
      Abstract: Publication date: November–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Supplement 1
      Author(s): Rafał Pawliczak


      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2016.03.001
       
  • Od Redaktora Naczelnego
    • Authors: Rafał Pawliczak
      First page: 1
      Abstract: Publication date: October–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Issue 4
      Author(s): Rafał Pawliczak


      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2016.03.001
       
  • Korzyści z leczenia omalizumabem wykraczające poza spodziewane efekty u
           38-letniej chorej na ciężką postać astmy alergicznej
    • Authors: Andrzej Obojski; Paulina Wełna; Robert Pawłowicz
      Abstract: Publication date: November–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Supplement 1
      Author(s): Andrzej Obojski, Paulina Wełna, Robert Pawłowicz
      We report the case of a 38-year-old woman suffering from allergic asthma since the age of 4. In the last 10 years, the patient presented with severe uncontrolled asthma with frequent exacerbations, despite stage-5 treatment according to GINA guidelines, including constant high doses of methylprednisolone. Long-time treatment with high doses of systemic corticosteroids induced many side effects including arterial hypertension, diabetes, GERD, hypercholesterolemia and obesity (weight 121kg, height 176cm, BMI 39kg/m2). Despite the treatment, asthma control remained poor, and quality of life and lung function test results were low (ACQ: 4,71 p, miniAQLQ: 3,2 p, FEV1 2,04 L 60,3% pred., FEV1/FVC 60,85%). The patient was enrolled into the omalizumab treatment program in March 2014. After 24 months of omalizumab treatment, the dose of methylprednisolone was reduced by 30mg/day. At the same time, asthma control and quality of life improved significantly (ACQ 1,85, miniAQLQ 4,73). Body weight was reduced by 30kg (BMI 29kg/m2) as well. Asthma exacerbation rate was also significantly reduced, and there was no asthma exacerbation in the last 12 months of the treatment. Unexpectedly, we observed improvement and further normalization of spirometry with finally normal FEV1/FVC ratio and FEV1 (FEV1 2,87 L 86,4% pred.). The patient has resumed her all daily-life activities.

      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2016.10.007
       
  • Skuteczne leczenia omalizumabem chorej na ciężką astmę alergiczną z
           utrzymującą się łagodną eozynofilią krwi obwodowej
    • Authors: Joanna Hermanowicz-Salamon; Renata Rubinsztajn
      Abstract: Publication date: November–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Supplement 1
      Author(s): Joanna Hermanowicz-Salamon, Renata Rubinsztajn
      A 46-year-old, non-smoking woman, treated for 18 years for allergic asthma associated with chronic sinusitis after bilateral ethmoidectomy in 02.2013, treated for hypertension and after cataract surgery in 2010 permanently treated with glucocorticosteroid treatment, was qualified for omalizumab treatment. She started therapy in March 2014. Despite oral glucocorticosteroids therapy (methylprednisolone 32– 4mg per day), blood eosinophil count remained high. In 16th and 52nd weeks of treatment, the effectiveness of omalizumab was assessed. Symptoms of asthma decreased which were expressed in ACQ and AQLQ along with an improvement in pulmonary function tests, associated with the reduction of daily oral glucocorticosteroids. Regardless of the improvement of asthma symptoms, mild blood eosinophilia was observed. In concomitance of severe asthma. inadequately controlled sinusitis and skin lesion EGPA were taken into account as reasons of all symptoms. EGPA was not confirmed in this patient, and mild eosinophilia was regarded as a phenotypic feature of asthma in this patient.

      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2016.10.004
       
  • Radykalna poprawa kontroli astmy oskrzelowej po włączeniu do leczenia
           omalizumabu – opis przypadku
    • Authors: Aleksandra Chudzicka; Renata Rożyńska; Adam Wesołowski
      Abstract: Publication date: November–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Supplement 1
      Author(s): Aleksandra Chudzicka, Renata Rożyńska, Adam Wesołowski
      Asthma is an important medical, social and economical problem. 5–10% of all patients with asthma constitute cases of severe asthma. One treatment method for severe asthma includes omalizumab. Its efficacy was acknowledged in many studies. We present a case of radical improvement of asthma control after omalizumab addition. It constitutes affirmation of drug efficacy.

      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2016.10.005
       
  • Pacjentka z ciężką astmą wyłączona z leczenia omalizumabem po 12
           tygodniach
    • Authors: Agnieszka Gawlewicz-Mroczka; Marek Przybyszowski; Weronika Zastrzeżyńska; Krzysztof Sładek
      Abstract: Publication date: November–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Supplement 1
      Author(s): Agnieszka Gawlewicz-Mroczka, Marek Przybyszowski, Weronika Zastrzeżyńska, Krzysztof Sładek
      We present the case of 20-year-old woman with the short history of severe course of asthma since its beginning. The patient met the inclusion criteria to omalizumab therapy in the program reimbursed by Polish Health Fund, so we expected that this therapy will enable to improve asthma control in the patient and decrease the dose of oral steroids or completely withdraw them. However within twelve weeks of therapy, the day of omalizumab application had to be rescheduled many times because of infectious asthma exacerbations. Moreover, in between exacerbations, asthma remained uncontrolled in spite of the very high doses of inhaled steroids and bronchodilators. Only on the day of last omalizumab injection, the patient reported better condition, and we observed improvement in spirometry and questionnaires score. We hoped that patient started to respond to the therapy. In the twelfth week of therapy, the patient reported that she became pregnant and had to be excluded from the therapeutical program. From the patients’ findings, high eosinophil count in peripheral blood as well as in broncho-alveolar lavage fluid were remarkable and chronic sinusitis preceded asthma diagnose.

      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2016.10.002
       
  • Astma prurigo
    • Authors: Jacek Gocki; Krystyna Romańska-Gocka; Zbigniew Bartuzi
      Abstract: Publication date: November–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Supplement 1
      Author(s): Jacek Gocki, Krystyna Romańska-Gocka, Zbigniew Bartuzi
      The term asthma prurigo defines the cases of coexistence of asthma and atopic dermatitis (AD). Patients with the combination of these two disease entities are still difficult to treat despite the significant advances in medicine. The described case of a patient showed that treatment with anti-IgE has the ability not only to fully control the symptoms of asthma, but also to gain control of troublesome symptoms for patients of atopic dermatitis, leading to a complete resolution changes on the skin.

      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2016.10.003
       
  • Terapia omalizumabem u pacjentki z ciężką eozynofilową astmą
           alergiczną i bólem stawów występującym podczas terapii – opis
           przypadku
    • Authors: Marek Przybyszowski; Agnieszka Gawlewicz-Mroczka; Weronika Zastrzeżyńska; Krzysztof Sładek
      Abstract: Publication date: November–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Supplement 1
      Author(s): Marek Przybyszowski, Agnieszka Gawlewicz-Mroczka, Weronika Zastrzeżyńska, Krzysztof Sładek
      Implementation of omalizumab in the treatment of patients with severe allergic asthma opened the possibility of obtaining optimal control of the disease and improving the quality of life. We present a case of a patient with severe allergic asthma qualified to biological treatment with omalizumab. Before qualification, the patient suffered from numerous severe exacerbations and uncontrolled asthma symptoms, despite treatment with high doses of inhaled medications and systemic corticosteroids. After 2 years of biological therapy, we achieved a significant, but incomplete improvement in asthma control, a marked improvement in the quality of life, and a decrease in the number of exacerbations. We observed persistent elevation of eosinophilia in peripheral blood and bronchoalveolar lavage, despite treatment with anti-IgE and systemic corticosteroids, indicating eosinophil phenotype of severe asthma. Moreover, in the course of therapy, the patient reported joint symptoms of unknown origin, which after further testing were eventually attributed to post-steroid complications and osteoarthritis. In appropriately qualified patients, treatment with omalizumab gives hope for significant improvement in asthma control. The development of new biological agents will allow individualizing asthma treatment depending on asthma phenotype and endotype.

      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2016.10.006
       
  • Astma ciężka – leczenie biologiczne omalizumabem –
           opis przypadku
    • Authors: Grzegorz Osmenda; Barbara Jasiewicz-Honkisz
      Abstract: Publication date: November–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Supplement 1
      Author(s): Grzegorz Osmenda, Barbara Jasiewicz-Honkisz
      A patient with long-lasting atopic asthma, allergic rhinitis, chronic idiopathic urticaria, decreased lung function, complaints of recurrent day and night symptoms, and exacerbations that need systemic GKS often visits the ER departments. During chronic treatment, the patient used a large dose of GKS and LABA, which were inhaled. The patient's condition changed after initiating treatment with omalizumab. We achieved clinical improvement, confirmed by the spirometry results, and reduction of intensity of asthma and urticaria with treatment.

      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2016.11.001
       
  • Pokrzywka przewlekła u chorej na ciężką astmę atopową – podwójna
           korzyść z leczenia omalizumabem
    • Authors: Joanna Goździk-Spychalska; Małgorzata Rzymkowska; Halina Batura-Gabryel
      Abstract: Publication date: November–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Supplement 1
      Author(s): Joanna Goździk-Spychalska, Małgorzata Rzymkowska, Halina Batura-Gabryel
      Urticaria is one of the most common skin disorders. A characteristic feature of this disease is the sudden appearance and rapid regression (up to 24hours) of blisters, angioedema, or both of these simultaneously. Often, the above changes are accompanied by symptoms of itching and pain. Chronic urticaria, i.e. one that lasts for at least 6 weeks, is divided into spontaneous (CSU) and induced. CSU, because of its unpredictable nature, strongly reduces the quality of life, especially the patient's active professionally and socially. Below is a description of a 38-year-old female patient, with the profession of teacher diagnosed with atopic chronic severe asthma coexisting with CSU, which has been qualified for the program with omalizumab in 2013, i.e., one year before the registration of the drug in the latter diagnosis. Since the inclusion of the patient into the program in addition to the vast improvement in asthma control in spite of the withdrawal of systemic corticosteroids (sGCS) and the reduction of inhaled glucocorticosteroids (ICS), any episode of CSU is not repeated which is undoubtedly the added benefit of applied therapy.

      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2016.10.001
       
  • Current guidelines for the evaluation and management of atopic dermatitis
           – A comparison of the Joint Task Force Practice Parameter and American
           Academy of Dermatology Guidelines
    • Authors: Lawrence F. Eichenfield; Jusleen Ahluwalia; Andrea Waldman; Jenna Borok; Jeremy Udkoff; Mark Boguniewicz
      Abstract: Publication date: Available online 21 November 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Lawrence F. Eichenfield, Jusleen Ahluwalia, Andrea Waldman, Jenna Borok, Jeremy Udkoff, Mark Boguniewicz
      Atopic dermatitis (AD) is a chronic, remitting-relapsing inflammatory dermatitis often managed by a multidisciplinary group of providers including allergists, dermatologists, and primary care practitioners. As the pathogenesis of AD is complex and multifactorial, there are numerous approaches to therapeutic management. Current AD management guidelines cover a broad range of interventions, from treating acute flares to environmental modifications. Allergists and dermatologists have both common and distinct approaches to AD management highlighted in their respective guidelines, providing multiple approaches to disease management. We compare and contrast the recent AAAAI/ACAAI JTF 2012 AD Practice Parameter and AAD 2014 guidelines, highlighting differing approaches to disease management.

      PubDate: 2017-11-27T08:50:06Z
      DOI: 10.1016/j.jaci.2017.01.009
       
  • Adipose tissue as a potential source of hormones and cytokines involved in
           asthma pathogenesis
    • Authors: Izabela Szymczak-Pajor; Rafal Pawliczak
      Abstract: Publication date: Available online 7 November 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Izabela Szymczak-Pajor, Rafal Pawliczak
      Asthma and obesity are chronic inflammatory diseases affecting millions of people worldwide. Numerous epidemiological data have revealed increased adiposity as a potential risk factor for severity and incidence of asthma. In addition, obesity is not only risk factor for asthma but is also related to its poor control. Despite the mechanism underlying obesity–asthma relation is not fully understood, it has been proposed that the common inflammatory mechanism plays a crucial role in determination of this relation. Adipose tissue is referred as extremely active endocrine organ secreting numerous hormones and cytokines that regulate immune responses and metabolism. In the lean state, the high levels of anti-inflammatory adipokines such as adiponetctin as well as low levels of pro-inflammatory adipokines i.e. leptin, and pro-inflammatory cytokines such as TNF-α, IL-8, IL-6 are secreted by adipose tissue. On the other hand, in the obese state, hypertrophic adipocytes and activated macrophages produce decreased level of adiponectin and increased levels of pro-inflammatory adipokines and cytokines leading to “metabolic inflammation”. It may be possible that these obesity-related pro-inflammatory adipokines may be associated with airway inflammation in obesity-related asthma. In the current review, we summarized the recent knowledge concerning possible molecular mechanisms mediating the relation between obesity and asthma.

      PubDate: 2017-11-10T14:28:32Z
      DOI: 10.1016/j.alergo.2017.10.001
       
  • Nadwrażliwość na leki – rekomendacje wobec praktyki
    • Authors: Mateusz Kaczmarczyk; Grzegorz Porębski
      Abstract: Publication date: Available online 27 September 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Mateusz Kaczmarczyk, Grzegorz Porębski
      Drug hypersensitivity reactions (DHRs) are an important public health concern related to the safety of individuals and the costs incurred in consequence for the health care system. DHRs are functionally and clinically heterogeneous. They are classified according to the timing of symptom appearance (immediate and nonimmediate reactions) or the type of mechanism (nonallergic or allergic, when the immune mechanisms are involved). Several guidelines and literature regarding the general and specific drug classes that induce hypersensitivity reactions have been recently published to assist in the management of DHRs. In this article, we highlight the key messages of the current recommendations and discuss the advances in knowledge of the mechanisms for the diagnosis and prevention of drug hypersensitivity reactions.

      PubDate: 2017-09-29T17:50:38Z
      DOI: 10.1016/j.alergo.2017.09.004
       
  • Zespoły nietolerancji amin biogennych. II. Tyramina, serotonina i
           inne
    • Authors: Krzysztof Łukasz Piwowarek; Jerzy Kruszewski
      Abstract: Publication date: Available online 27 September 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Krzysztof Łukasz Piwowarek, Jerzy Kruszewski
      Histamine intolerance is the most important biogenic amines intolerance syndrome, but not the only one. Clinically, significant reactions may be induced by tyramine, serotonin, putrescine, cadaverine, phenylethylamine and tryptamine. Substantial variation of these highly bioactive compounds determines multiplicity of potentially caused symptoms. In addition, the situation is complicated by frequent co-occurrence in food products. Therefore, the diagnostics of biogenic amines intolerance syndromes is difficult and depends heavily on meticulously collected information through an interview. The intention of the following literature review is to present the aforementioned subject.

      PubDate: 2017-09-29T17:50:38Z
      DOI: 10.1016/j.alergo.2017.09.005
       
  • Wybrane reakcje krzyżowe w alergiach górnych dróg
           oddechowych i pokarmowych
    • Authors: Krzysztof Buczyłko; Emilia Majsiak
      Abstract: Publication date: Available online 20 September 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Krzysztof Buczyłko, Emilia Majsiak
      Allergic rhinitis, stomatitis, pharyngitis, laryngitis and oesophagitis are characterized by IgE-mediated reactions. There was a strong correlation between mites component resolved diagnostic (CRD) and chronic allergic rhinitis. CRD had important influence on cross- reaction's diagnostics. The majority of birch allergic patients are IgE-sensitized to the major birch pollen allergen Bet v 1 as well as to the major apple CRD Mal d 1 and soy bean allergen Gly m 4. Birch pollen-related oral allergy syndrome (OAS) is a common type of food allergy, transient and mild in nature. More information is discovered about the possible causal association between allergy and vocal pathologies or eosinophilic eosophagitis (EoE). Cross-reactivity of the wheat CRD may be important. Allergenic extracts and molecular components are available at present in FABER test. Allergen molecular diagnostics may represent a useful way in allergy work-up. Many data suggest that components resolved diagnostics constitutes a reliable tool for the diagnosis of pollen-food syndromes or other form of cross-reactivity.

      PubDate: 2017-09-24T16:31:07Z
      DOI: 10.1016/j.alergo.2017.09.003
       
  • Position Paper of Food Allergy Section the Polish Society of Allergology
           on the diagnosis and management of food allergies
    • Authors: Z. Bartuzi; M. Kaczmarski; M. Czerwionka-Szaflarska; T. Małaczyńska; A. Krogulska
      Abstract: Publication date: Available online 14 September 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Z. Bartuzi, M. Kaczmarski, M. Czerwionka-Szaflarska, T. Małaczyńska, A. Krogulska
      The paper concerns the current position of the Polish Society of Allergology Food Allergy Section on the diagnosis and management of food allergies. The aim of this position is to provide evidence-based recommendations on the diagnosis and management of patients with allergic hypersensitivity to foods. This position statement includes a systematic review of studies in three areas, namely the epidemiology, diagnosis and management of food allergies. While taking into account the specific Polish setting, we also used in this publication the current European Academy of Allergy and Clinical Immunology (EAACI) position paper and other current position statements, including those of the United States National Institute of Allergy and Infectious Diseases (NIAID).

      PubDate: 2017-09-18T13:43:09Z
      DOI: 10.1016/j.alergo.2017.09.002
       
  • 23-letnia chora na astmę oskrzelową z utrwalonymi zaburzeniami
           wentylacji ciężkiego stopnia
    • Authors: Farnik
      Abstract: Publication date: November–December 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Supplement 1
      Author(s): Małgorzata Farnik
      A 23-year-old female reported with atopic asthma and allergic rhinitis diagnosed in childhood, and complaints of frequent exacerbations since adolescence. Spirometry showed gradual progression of obstruction – at the age of 20 – representing very severe obturation. The patient never smoked and had no exposition to any potential irritation factors. Due to frequent exacerbations, the patient often required systemic glucocorticoids; at the age of 21, she was diagnosed with TB. After the antituberculosis treatment was completed, reversibility test was negative, and slow progression of obstruction was still observed (FEV1 20% of predicted value). The patient had presented depression symptoms. She was qualified for anti-IgE treatment; after 8 months, clinically significant improvement was observed – the number of exacerbations was reduced and systemic GCS has been stopped. Spirometry had showed improvement with FEV1 – 38% of predicted. As the exercise tolerance improved, the patient has resumed her academic studies.

      PubDate: 2017-09-18T13:43:09Z
       
  • Grzybica skóry gładkiej leczona jako alergia kontaktowa
    • Authors: Monika Sikorska; Roman Nowicki
      Abstract: Publication date: Available online 8 September 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Monika Sikorska, Roman Nowicki
      Fungal skin infections are caused mainly by dermatophytes of the genus Trichophyton, Microsporum and Epidermophyton. Proper diagnosis based on clinical picture and mycological examination makes it possible to implement effective treatment – local, general or combination. Mycobacterial mycosis mostly develops on the skin of the scalp in the form of single or multiple lesions without inflammation. Zoophilic dermatophyte Microsporum canis is the most common causative pathogen, anthropophilic species such as Microsporum audouinii and Microsporum ferrugineum are observed occasionally. In case of zoonitic mycosis, a characteristic inflammation is formed on the periphery. Outside the scalp, skin of the face, neck, shoulders and the trunk can also be affected. Mycosis of smooth skin manifests in the form of oval or round erythematous patches or plaques with sharply defined borders, which spread circumferentially. The periphery of the lesion is inflamed with scaling and pustules, and centrally located resolution is observed. Pruritus in majority of the cases is a chief complaint. In most of the cases, a single lesion is observed, but over time, lesions tend to multiply and fuse together. Differential diagnosis of mycosis of the smooth skin includes seborrheic dermatitis, Gilbert's pink dandruff, mycosis fungoides, psoriasis and nummular dermatitis. The basis of treatment for microsporiasis is the use of topical preparations with antifungal agents. Local treatment is sufficient in most of the cases. General treatment (terbinafine, itraconazole, fluconazole or chleeprazole) is recommended if there is no improvement after topical treatment or in advanced disease stages. This article presents the case of a woman whose single facial fungal skin lesion was misdiagnosed as allergic contact dermatitis. Topical treatment with moderate-potent corticosteroids was used to achieve initial clinical improvement but discontinuation of therapy led to evolution of the lesion, which partially lost its original ring-shaped nature. The final diagnosis was based on mycological examination, and local and general antifungal treatment led to permanent cure. Not typical mycotic skin disease altered by immunosuppressive treatment is termed tinea incognito. Carelessly prescribing and using corticosteroids for infectious skin lesions results in complications as well as postponement of proper diagnosis and initiation of the treatment.

      PubDate: 2017-09-12T13:39:05Z
      DOI: 10.1016/j.alergo.2017.08.003
       
  • Wpływ środowiska wiejskiego na rozwój astmy i alergii u
           dzieci
    • Authors: Piotr Fuss; Katarzyna Bal-Gierańczyk; Joanna Jerzyńska; Iwona Stelmach
      Abstract: Publication date: Available online 8 September 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Piotr Fuss, Katarzyna Bal-Gierańczyk, Joanna Jerzyńska, Iwona Stelmach
      Children who grow up on dairy farms rarely develop asthma or allergies. Researchers suspect a key reason is that the kids breathe in air full of lipopolysaccharides, molecules from the cell wall of bacteria G-, known as endotoxins. Endotoxin-reduced epithelial cell cytokines activate dendritic cells (DCs), thus suppressing type 2 immunity to house dust mites and reducing the overall reactivity of the immune system and later protecting children from asthma. Schuijs et al showed that an enzyme involved in this defense, called A20, is made by the epithelial cells. Loss of the ubiquitin-modifying enzyme A20 abolished the protective effect. Thus, the farming environment protects from allergy by modifying the communication between barrier epithelial cells and DCs through A20 induction. Their study offers new support for the hygiene hypothesis, which posits that zeal for cleanliness and widespread use of antibiotics have purged the environment of microorganisms that once taught a child's developing immune system not to overreact to foreign substances. This paper is a summary of up-to-date information on hygiene hypothesis. The purpose is to review the important recent advances made in how innate immune cells, microbes, and the environment contribute to the expression of allergic disease, emphasizing the allergen-related signals that drive allergic responses.

      PubDate: 2017-09-12T13:39:05Z
      DOI: 10.1016/j.alergo.2017.08.002
       
  • Atopowe zapalenie skóry. Czy zawsze choroba alergiczna'
    • Authors: Barbara Rogala
      Abstract: Publication date: Available online 8 September 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Barbara Rogala


      PubDate: 2017-09-12T13:39:05Z
      DOI: 10.1016/j.alergo.2017.08.004
       
  • Probiotics for the prevention of atopic dermatitis and other allergic
           diseases: What are the real facts'
    • Authors: Magdalena Czarnecka-Operacz; Anna Sadowska-Przytocka
      Abstract: Publication date: Available online 5 September 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Magdalena Czarnecka-Operacz, Anna Sadowska-Przytocka
      Atopic dermatitis (AD) is one of the most common inflammatory skin diseases diagnosed all over the world. The course of this complicated disease is chronic and relapsing and there have been many variants both endogenic and phenotypic already described and despite of our better understanding of AD we have no well “structured” therapeutical approach to many of our patients. Mainly because we do not understand it in an adequate way and complexity of treatment must be highly individualized. Recent studies suggest prevention of AD can be achieved through early intervention to protect the disturbed skin barrier. While the skin lesions are developed AD requires appropriate control of local and systemic immune activation for optimal management which obviously may cause the whole variety of adverse events. Therefore it seems that early intervention might improve long-term outcomes of AD and reduce the risk of development of systemic sensitization that leads to associated allergic/atopic diseases within the gastrointestinal and respiratory tract. For some time probiotics have been suggested as an intervention to prevent allergic diseases such as AD. Therefore besides many publications, a systematic review of randomized trials assessing the effect of any probiotics administered to pregnant women breast-feeding mothers, and/or infants have been analyzed in this review paper in order to state what is the “real truth” about this type of preventive approach.

      PubDate: 2017-09-06T13:34:57Z
      DOI: 10.1016/j.alergo.2017.08.001
       
  • miRNA – rola i znaczenie w astmie oskrzelowej
    • Authors: Maksymilian Ziaja; Rafał Pawliczak
      Abstract: Publication date: Available online 1 August 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Maksymilian Ziaja, Rafał Pawliczak
      Chronic inflammatory airway diseases, including asthma, are a significant health problem and previous treatment methods seem to be insufficient. There is a lack of effective therapies which are adjusted to treat all classes in terms of severity, and it is probably caused by insufficient understanding of molecular mechanisms involved in its occurrence. Small non-coding microRNA molecules in response to environmental factors lead to modulate gene expression. They regulate many processes associated with physiologic functions of the immune system. Researches showed crucial role of miRNA in pathogenesis of asthma and the other chronic inflammatory airway diseases. Despite the link of microRNA with pathogenesis of inflammatory airway diseases, the role of these molecules is still unclear. More detailed knowledge of the impact of miRNA molecules on the development of bronchial asthma would allow us to better understand the genesis process and might influence the effectiveness of the bronchial asthma treatment.

      PubDate: 2017-08-10T13:19:01Z
      DOI: 10.1016/j.alergo.2017.07.001
       
  • Nasal allergen challenge in clinical practice – A real life study
    • Authors: Maciej Kupczyk; Kamila Malewska; Aleksandra Pyziak; Aleksandra Szostakowska; Piotr Kuna
      Abstract: Publication date: Available online 10 July 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Maciej Kupczyk, Kamila Malewska, Aleksandra Pyziak, Aleksandra Szostakowska, Piotr Kuna
      Nasal allergen challenge represents, together with skin tests and specific IgE, one of the basic diagnostic tools used in allergology. The goals of the study were to evaluate types of allergens used, the clinical picture of the challenge, and its safety in our daily clinical practice. In total 136 challenges in 109 patients were analyzed. The study group included 60 women and 49 men, with an average age of 34 years. In 15 patients (13.8% of the study group), apart from allergic rhinitis, bronchial asthma was also diagnosed. Eighty-two patients (75.23%) were challenged with 1, and 27 subjects (24.77%) with 2 allergens. The majority of challenges were performed with house dust mites (58 challenges, 42.6%), followed by Alternaria, mugwort, grasses, birch, hazel, and alder. The clinical picture mimicked the symptoms reported after the natural exposure to the specific allergen. The mean score after the allergen challenge in the group with the positive result was 154.95 points (p <0.05 vs control solution), and in those with negative challenge 36.67 points. Side effects after the challenge, including itchy throat, cough, dyspnea and facial pruritus, were reported by 21 patients. None of side effects was serious or required any medical intervention. Among evaluated factors only female sex (OR 3.59, 95% CI 1.33–9.68, p =0.012), but not diagnosis of asthma, 2 challenges per day or the type of allergen used, was associated with a higher risk of adverse events. In conclusions, nasal allergen challenge represents safe and valuable diagnostic tool in our clinical practice.

      PubDate: 2017-07-14T13:01:24Z
      DOI: 10.1016/j.alergo.2017.06.004
       
  • Przewlekłe zapalenie zatok obocznych nosa: spojrzenie alergologa i
           laryngologa
    • Authors: Paweł Bielecki; Andrzej Sieśkiewicz; Marcin Garkowski; Marek Rogowski; Krzysztof Kowal
      Abstract: Publication date: Available online 16 June 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Paweł Bielecki, Andrzej Sieśkiewicz, Marcin Garkowski, Marek Rogowski, Krzysztof Kowal
      Chronic rhinosinusitis (CRS) is an inflammatory disorder which affects mucosa of nasal cavity and sinuses and lasts for at least 12-week duration. Many studies exploring association between allergy and CRS have been conducted. The most frequent allergic diseases which co-exist with CRS are asthma, allergic rhinitis and aspirin intolerance. Appropriate therapy of CRS should include both severity of symptoms and histopathologic characteristics. Initial treatment should relay on pharmacological control of symptoms using intranasal steroids, local irrigations and systemic antibiotics. Surgical interventions are usually performed whenever initial therapy fails. Despite appropriate therapy symptoms of CRS tend to recur. Therefore patients with CRS should be systematically evaluated by allergists and laryngologists. New pharmacological options including biologics may allow for more effective treatment.

      PubDate: 2017-06-20T06:49:31Z
      DOI: 10.1016/j.alergo.2017.06.002
       
  • Early effects of ultra-rush wasp-venom immunotherapy on the expression of
           CD25 on CD4+ T cells
    • Authors: Kamil Grubczak; Maria Magdalena Tomasiak-Łozowska; Maciej Klimek; Andrzej Eljaszewicz; Anna Bodzenta-Łukaszyk; Marcin Moniuszko
      Abstract: Publication date: Available online 15 June 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Kamil Grubczak, Maria Magdalena Tomasiak-Łozowska, Maciej Klimek, Andrzej Eljaszewicz, Anna Bodzenta-Łukaszyk, Marcin Moniuszko
      To date, early effects of specific immune therapy on the parameters of adaptive immune responses in hymenoptera venom allergic patients remain unclear. Therefore, in this pilot study, we aimed to evaluate early changes in the levels of CD25 expression within CD4+ T cells occurring in the course of ultra-rush wasp venom immunotherapy. To this end, ten wasp venom-sensitive patients subjected to ultra-rush immune therapy were recruited for the study. CD4+ T cells and CD25 expression were assessed before the start of treatment, 24h later and on day 120 with the use of monoclonal antibodies directed at CD4, CD25 (IL-2 receptor) by the means of multi-color flow cytometry. We have demonstrated non-significant decrease in the intensity of CD25 expression on the surface of CD4+ T cells at day 1 but not day 120 of specific immune therapy. Our study suggests that putative early immunosuppressive mechanisms of SIT are not related to dramatic changes in the expression of CD25 on CD4+ T cells.

      PubDate: 2017-06-20T06:49:31Z
      DOI: 10.1016/j.alergo.2017.06.001
       
  • Farmakoekonomiczne aspekty zastosowania immunoterapii alergenowej w
           leczeniu alergicznego nieżytu nosa i astmy
    • Authors: Radosław Gawlik; Grzegorz Zagórny; Andrzej Bożek
      Abstract: Publication date: Available online 7 June 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Radosław Gawlik, Grzegorz Zagórny, Andrzej Bożek
      Allergic rhinitis is a most common allergic disease affecting 40% of the population. The impact of AR on health-related quality of life (QoL) and productivity results in a significant economic burden. Allergen immunotherapy is the only causative treatment of allergic rhinitis and asthma. However, it is still unclear whether AIT is more cost-effective than the other treatments of AR without long-term cost-effectiveness studies. There is a need for further economic evaluations comparing different ways of immunotherapy and immunotherapy with pharmacotherapy.

      PubDate: 2017-06-10T03:42:44Z
      DOI: 10.1016/j.alergo.2017.05.002
       
  • 13. Akademia Dermatologii i Alergologii Słupsk − Ustka − Dolina
           Charlotty 09−12 lutego 2017 roku
    • Authors: Maciej Kaczmarski
      Abstract: Publication date: Available online 24 May 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Maciej Kaczmarski


      PubDate: 2017-05-26T03:18:43Z
      DOI: 10.1016/j.alergo.2017.05.001
       
  • The presence of atopy and its effect on bacterial colonization of the
           upper airways in children with adenoid vegetation
    • Authors: Gabriela Bugova; Barbora Uhliarova; Milos Jesenak; Andrej Hajtman
      Abstract: Publication date: Available online 3 May 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Gabriela Bugova, Barbora Uhliarova, Milos Jesenak, Andrej Hajtman
      Background: The aim of this study was to determine the frequency of atopy and the influence of atopy on bacterial colonization of upper airway in children with adenoid hypertrophy. Material and methods: Forty children were enrolled in the prospective study. Presence of atopy was diagnosed by skin-prick test. Differences in bacterial colonization of middle nasal meatus and nasopharynx according to the presence of atopy were analyzed. Results: Atopy was diagnosed in 75% children with adenoid hypertrophy. Presence of atopy was associated with significantly more often colonization of pathogenic bacteria (Streptococcus pneumoniae, Hemophillus influaenzae, Moraxella catarrhalis, Staphylococcus aureus) in the middle nasal meatus but not in nasopharynx (P =0.045, P =0.483, respectively). Identification of pathogenic bacteria in middle nasal meatus did not correlate with isolation of pathogenic bacteria in nasopharynx in both groups of children. Conclusion: There is a high incidence of atopy in children with adenoid hypertrophy. Atopy is related to increased colonization by pathogenic bacteria in middle nasal meatus but not in nasopharynx.

      PubDate: 2017-05-05T23:15:39Z
      DOI: 10.1016/j.alergo.2017.04.002
       
  • Unusual pulmonary manifestations in hepatitis B associated polyarteritis
           nodosa
    • Authors: Animesh Ray; Vivek Nangia; Rajat Chatterji; Navin Dalal
      Abstract: Publication date: Available online 2 May 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Animesh Ray, Vivek Nangia, Rajat Chatterji, Navin Dalal


      PubDate: 2017-05-05T23:15:39Z
      DOI: 10.1016/j.alergo.2017.04.001
       
  • The role of microbiota in allergy development
    • Authors: Monika Marko; Rafał Pawliczak
      Abstract: Publication date: Available online 31 March 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Monika Marko, Rafał Pawliczak
      The increase of allergic diseases incidence has been noticed in industrialized countries. The reason for that is sought in increasing environment pollution and hygienisation of life. Diseases including asthma, hay fever, eczema and food allergies have dramatically increased over the last century. Microbiota (intestinal microflora) is a community of microorganisms, mainly bacteria that forms in the human digestive system a complex ecosystem. Recently more and more attention is paid to the connection of intestinal microflora with the occurrence of allergic diseases. Microbiota and the beneficial effects of probiotic bacteria on human health is becoming increasingly important in allergy development. However, the importance of probiotics in the prevention of these diseases has not been proven. It is a necessity to design and carry out thorough and detailed research to confirm significance of treatment with using probiotics strains.

      PubDate: 2017-04-01T22:54:13Z
      DOI: 10.1016/j.alergo.2017.03.002
       
  • Od Redaktora Naczelnego
    • Authors: Rafał Pawliczak
      Abstract: Publication date: Available online 8 March 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Rafał Pawliczak


      PubDate: 2017-03-08T18:37:22Z
      DOI: 10.1016/j.alergo.2017.03.001
       
  • Minimalna różnica istotna klinicznie (MCID) dla zmniejszenia częstości
           zaostrzeń przewlekłej obturacyjnej choroby płuc – czyli, która
           terapia jest w rzeczywistości odczuwana przez chorego
    • Authors: Tomasz
      Abstract: Publication date: Available online 6 March 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Tomasz Dębowski
      Exacerbations of COPD are associated with accelerated loss of lung function, declining health status, and increased mortality, and the key objective in the management of COPD is preventing exacerbations or at least reducing their number and severity. New interventions should be examined in reference to the minimal clinically important difference (MCID), a theoretical numerical value which reflects the real, felt by patients and perceived by physician as a meaningful change in measures describing patient's health status. The MCID for COPD exacerbations had been established and set on the level of 20% reduction in exacerbation frequency.

      PubDate: 2017-03-08T18:37:22Z
       
  • Leczenie astmy, dziś i jutro – perspektywa osobista
    • Authors: Marek Kokot
      Abstract: Publication date: Available online 21 February 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Marek Kokot
      Contemporary asthma treatment has been started with inhaled corticosteroids’ introduction to the common medical practice. Universal abundance of this kind of treatment completely changed the clinical picture of asthma and therefore these drugs permanently entered the treatment canon. Current attitude to asthma pharmacotherapy was shaped by the evidence based medicine paradigm. That time inhaled long acting beta 2 mimetics were launched as well. Today, still inhaled corticosteroids and long acting beta 2 mimetics are the mainstay asthma treatment. Beginning of the XXI century was the stormy entrance of the new personalized medicine paradigm and the crisis of the evidence-based medicine could be noticed as a result. These new concepts influence more and more the current asthma treatment. Especially the new biologics and pharmacotherapy tailored to individual patients needs will form the future of the medical behavior in this area.

      PubDate: 2017-02-23T15:16:06Z
      DOI: 10.1016/j.alergo.2017.02.006
       
  • Tabletka podjęzykowa – nowa jakość w immunoterapii
           alergenowo-swoistej
    • Authors: Rafał Pawliczak
      Abstract: Publication date: Available online 16 February 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Rafał Pawliczak
      Allergen immunotherapy has a well-established role in the treatment of allergic rhinitis and conjunctivitis. Sublingual allergen immunotherapy seems to have a similar impact on symptoms and medication score as compared to classic, subcutaneous immunotherapy. Due to the fact that sublingual immunotherapy utilizes several approaches, in this review we are comparing clinical trials data for two of the most common allergen tablets, Grazax and Oralair. Based on these data we suggest that pre and co-seasonal treatment is efficient only when Oralair is prescribed, whereas Grazax should be used in only in an all-year-around manner in order to obtain clinical efficacy. Further, more well-designed clinical trials are needed to establish the pre and co-seasonal treatment efficacy with Grazax.

      PubDate: 2017-02-16T22:23:56Z
      DOI: 10.1016/j.alergo.2017.02.005
       
  • Bronchial allergen challenge – An old, but still useful tool in
           research and diagnostics
    • Authors: Zenon Siergiejko; Grzegorz Siergiejko; Mark Klukowski; Ewa Maria Swiebocka
      Abstract: Publication date: Available online 16 February 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Zenon Siergiejko, Grzegorz Siergiejko, Mark Klukowski, Ewa Maria Swiebocka
      A bronchial allergen challenge may serve both as a diagnostic as well as investigative procedure. Its usage in the diagnosis of asthma is infrequent due to its time-consuming nature as well as (in our opinion) an unfounded fear for a patient's safety. It is quite useful in the diagnostics of workplace related illnesses. Due to its ability to produce a controlled, long-lasting allergic-inflammatory reaction in the bronchi, this procedure is commonly used in research settings as well as in the assessment of new substances which may potentially have a place in the treatment of asthma, for ex. through the blocking of late asthmatic reactions. Changes stimulated by a bronchial allergen challenge may be evaluated by many methods using different materials, i.e. samples obtained from direct biopsies, bronchoalveolar lavages, exhaled breath condensates, or measured fractional exhaled nitric oxide. This procedure is a seemingly ideal research and diagnostic tool, however, a common protocol for its execution has not yet been accepted. Recent legal regulations have resulted in difficulties obtaining various allergens for challenge tests. Hopefully this is a temporary and minor setback for this very useful and constantly developing procedure.

      PubDate: 2017-02-16T22:23:56Z
      DOI: 10.1016/j.alergo.2017.02.004
       
  • Scaling up strategies of the chronic respiratory disease programme of the
           European Innovation Partnership on Active and Healthy Ageing – Executive
           summary
    • Authors: Th. Werfel; P. Hellings; I. Agache; A. Muraro; J. Bousquet
      Abstract: Publication date: Available online 13 February 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Th. Werfel, P. Hellings, I. Agache, A. Muraro, J. Bousquet
      Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory diseases action plan involves AIRWAYS integrated care pathways (ICPs). It is deployed in collaboration with the WHO Global Alliance against Chronic Respiratory Diseases (GARD). The EIP on AHA has proposed a 5-step framework for developing an individual scaling up strategy: (i) what to scale up: (i-a) databases of good practices, (i-b) assessment of viability of the scaling up of good practices, (i-c) classification of good practices for local replication and (ii) how to scale up: (ii-a) facilitating partnerships for scaling up, (ii-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory diseases action plan of the EIP on AHA.

      PubDate: 2017-02-16T22:23:56Z
      DOI: 10.1016/j.alergo.2017.02.002
       
  • The role and choice criteria of antihistamines in allergy management
           – Expert opinion
    • Authors: Piotr Kuna; Dariusz Jurkiewicz; Magdalena M. Czarnecka-Operacz; Rafał Pawliczak; Jarosław Woroń; Marcin Moniuszko; Andrzej Emeryk
      Abstract: Publication date: Available online 10 February 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Piotr Kuna, Dariusz Jurkiewicz, Magdalena M. Czarnecka-Operacz, Rafał Pawliczak, Jarosław Woroń, Marcin Moniuszko, Andrzej Emeryk
      Allergic diseases are the most common chronic conditions lasting throughout the patient's life. They not only cause significant deterioration in the quality of life of patients but also lead to significant absenteeism and reduced productivity, resulting in very high costs for society. Effective and safe treatment of allergic diseases is therefore one of the main challenges for public health and should be carried out by all the specialists in family medicine, internists and paediatricians in collaboration with allergists, otorhinolaryngologists and dermatologists. Antihistamines are most commonly used in the treatment of allergies. Several dozen drugs are available on the pharmaceutical market, and their generic forms are advertised widely as very effective drugs for the treatment of allergic diseases. What is the truth' What are the data from clinical trials and observational studies' Are all drugs equally effective and safe for the patient' According to a panel of experts representing various fields of medicine, inappropriate treatment of allergies can be very risky for patients, and seemingly equally acting medications may differ greatly. Therefore, a panel of experts gathered the latest data from the entire scientific literature and analyzed the latest standards and recommendations prepared by scientific societies. This paper provides a summary of these studies and highlights the importance for the patient of the proper choice of drug to treat his allergies.

      PubDate: 2017-02-10T22:19:37Z
      DOI: 10.1016/j.alergo.2017.02.001
       
 
 
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