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Publisher: Elsevier   (Total: 3030 journals)

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Showing 1 - 200 of 3030 Journals sorted alphabetically
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 20, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 16, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 79, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 22, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 27, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 4)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 5, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 303, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 3)
Acta Biomaterialia     Hybrid Journal   (Followers: 25, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription  
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 196, SJR: 3.683, h-index: 202)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.615, h-index: 21)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 9, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription   (Followers: 1)
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 3, SJR: 0.311, h-index: 16)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 2)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 21, SJR: 1.365, h-index: 73)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 5, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 4)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.383, h-index: 19)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 2)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 5, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 4, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 4)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 5)
Additive Manufacturing     Hybrid Journal   (Followers: 7, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 20)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 120, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 16, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 8, SJR: 0.299, h-index: 15)
Advances in Agronomy     Full-text available via subscription   (Followers: 15, SJR: 2.071, h-index: 82)
Advances in Anesthesia     Full-text available via subscription   (Followers: 24, SJR: 0.169, h-index: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 3)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 6, SJR: 1.054, h-index: 35)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 10, SJR: 0.801, h-index: 26)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 21, SJR: 1.286, h-index: 49)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
Advances in Botanical Research     Full-text available via subscription   (Followers: 3, SJR: 0.619, h-index: 48)
Advances in Cancer Research     Full-text available via subscription   (Followers: 26, SJR: 2.215, h-index: 78)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 0.9, h-index: 30)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 2.139, h-index: 42)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 24, SJR: 0.183, h-index: 23)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 8, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 16, SJR: 0.223, h-index: 22)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 11)
Advances in Digestive Medicine     Open Access   (Followers: 4)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Ecological Research     Full-text available via subscription   (Followers: 39, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 25, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 7)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 38, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 3)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 41, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 14)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 18, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.497, h-index: 31)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 22)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 33, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 3, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 4)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 4)
Advances in Life Course Research     Hybrid Journal   (Followers: 7, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 8)
Advances in Marine Biology     Full-text available via subscription   (Followers: 16, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 5, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 21)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 10)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 6, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 3)
Advances in Oncobiology     Full-text available via subscription   (Followers: 3)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 20, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 14)
Advances in Pharmacology     Full-text available via subscription   (Followers: 13, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 7, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 4)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 17, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 56)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 1, SJR: 0.1, h-index: 2)
Advances in Space Research     Full-text available via subscription   (Followers: 332, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 7)
Advances in Surgery     Full-text available via subscription   (Followers: 6, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 28, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 14)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 12)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 42, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 5, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 304, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 4, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 7, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 390, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 29, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 36, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access  
Agriculture and Natural Resources     Open Access   (Followers: 1)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 48, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 3, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 9, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 5)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access  
Algal Research     Partially Free   (Followers: 7, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 5, SJR: 0.776, h-index: 35)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 6, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 45, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 5)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 3)
American Heart J.     Hybrid Journal   (Followers: 45, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 47, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 34, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 6, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 32, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 25, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 31, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 48, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 174, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 51, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 2)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 22, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 23, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 21, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 32, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 13, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 5)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 52, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 3)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 2, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 38, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 154, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 7, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 10)
Anesthésie & Réanimation     Full-text available via subscription  
Anesthesiology Clinics     Full-text available via subscription   (Followers: 21, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access  
Animal Behaviour     Hybrid Journal   (Followers: 143, SJR: 1.907, h-index: 126)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 5, SJR: 1.151, h-index: 83)
Animal Reproduction Science     Hybrid Journal   (Followers: 5, SJR: 0.711, h-index: 78)
Annales d'Endocrinologie     Full-text available via subscription   (SJR: 0.394, h-index: 30)
Annales d'Urologie     Full-text available via subscription  
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (SJR: 0.177, h-index: 13)
Annales de Chirurgie de la Main et du Membre Supérieur     Full-text available via subscription  
Annales de Chirurgie Plastique Esthétique     Full-text available via subscription   (Followers: 2, SJR: 0.354, h-index: 22)
Annales de Chirurgie Vasculaire     Full-text available via subscription   (Followers: 1)

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Journal Cover Alergologia Polska : Polish Journal of Allergology
  [1 followers]  Follow
    
   Full-text available via subscription Subscription journal  (Not entitled to full-text)
   ISSN (Print) 2353-3854
   Published by Elsevier Homepage  [3030 journals]
  • Międzynarodowy konsensus dotyczący immunoterapii alergenowej
           – ICON AIT 2015
    • Authors: Andrzej Emeryk; Małgorzata Emeryk
      Pages: 9 - 12
      Abstract: Publication date: January–March 2016
      Source:Alergologia Polska - Polish Journal of Allergology, Volume 3, Issue 1
      Author(s): Andrzej Emeryk, Małgorzata Emeryk
      The aim of the article is to present the main recommendations relating to the application of allergen immunotherapy (AIT) in various allergic diseases contained in international consensus on allergy immunotherapy (ICON) published in 2015. There is practically no controversy about the use of AIT in the treatment of allergic rhinitis and allergic asthma in children and adults, but for atopic dermatitis (especially in adults) or food allergy (in children and adults), the indications for AIT are not well defined.

      PubDate: 2017-04-22T23:08:10Z
      DOI: 10.1016/j.alergo.2016.01.003
       
  • The role of microbiota in allergy development
    • Authors: Monika Marko; Rafał Pawliczak
      Abstract: Publication date: Available online 31 March 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Monika Marko, Rafał Pawliczak
      The increase of allergic diseases incidence has been noticed in industrialized countries. The reason for that is sought in increasing environment pollution and hygienisation of life. Diseases including asthma, hay fever, eczema and food allergies have dramatically increased over the last century. Microbiota (intestinal microflora) is a community of microorganisms, mainly bacteria that forms in the human digestive system a complex ecosystem. Recently more and more attention is paid to the connection of intestinal microflora with the occurrence of allergic diseases. Microbiota and the beneficial effects of probiotic bacteria on human health is becoming increasingly important in allergy development. However, the importance of probiotics in the prevention of these diseases has not been proven. It is a necessity to design and carry out thorough and detailed research to confirm significance of treatment with using probiotics strains.

      PubDate: 2017-04-01T22:54:13Z
      DOI: 10.1016/j.alergo.2017.03.002
       
  • Od Redaktora Naczelnego
    • Authors: Rafał Pawliczak
      Abstract: Publication date: Available online 8 March 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Rafał Pawliczak


      PubDate: 2017-03-08T18:37:22Z
      DOI: 10.1016/j.alergo.2017.03.001
       
  • Minimalna różnica istotna klinicznie (MCID) dla zmniejszenia częstości
           zaostrzeń przewlekłej obturacyjnej choroby płuc – czyli, która
           terapia jest w rzeczywistości odczuwana przez chorego
    • Authors: Tomasz
      Abstract: Publication date: Available online 6 March 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Tomasz Dębowski
      Exacerbations of COPD are associated with accelerated loss of lung function, declining health status, and increased mortality, and the key objective in the management of COPD is preventing exacerbations or at least reducing their number and severity. New interventions should be examined in reference to the minimal clinically important difference (MCID), a theoretical numerical value which reflects the real, felt by patients and perceived by physician as a meaningful change in measures describing patient's health status. The MCID for COPD exacerbations had been established and set on the level of 20% reduction in exacerbation frequency.

      PubDate: 2017-03-08T18:37:22Z
       
  • Leczenie astmy, dziś i jutro – perspektywa osobista
    • Authors: Marek Kokot
      Abstract: Publication date: Available online 21 February 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Marek Kokot
      Contemporary asthma treatment has been started with inhaled corticosteroids’ introduction to the common medical practice. Universal abundance of this kind of treatment completely changed the clinical picture of asthma and therefore these drugs permanently entered the treatment canon. Current attitude to asthma pharmacotherapy was shaped by the evidence based medicine paradigm. That time inhaled long acting beta 2 mimetics were launched as well. Today, still inhaled corticosteroids and long acting beta 2 mimetics are the mainstay asthma treatment. Beginning of the XXI century was the stormy entrance of the new personalized medicine paradigm and the crisis of the evidence-based medicine could be noticed as a result. These new concepts influence more and more the current asthma treatment. Especially the new biologics and pharmacotherapy tailored to individual patients needs will form the future of the medical behavior in this area.

      PubDate: 2017-02-23T15:16:06Z
      DOI: 10.1016/j.alergo.2017.02.006
       
  • Tabletka podjęzykowa – nowa jakość w immunoterapii
           alergenowo-swoistej
    • Authors: Rafał Pawliczak
      Abstract: Publication date: Available online 16 February 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Rafał Pawliczak
      Allergen immunotherapy has a well-established role in the treatment of allergic rhinitis and conjunctivitis. Sublingual allergen immunotherapy seems to have a similar impact on symptoms and medication score as compared to classic, subcutaneous immunotherapy. Due to the fact that sublingual immunotherapy utilizes several approaches, in this review we are comparing clinical trials data for two of the most common allergen tablets, Grazax and Oralair. Based on these data we suggest that pre and co-seasonal treatment is efficient only when Oralair is prescribed, whereas Grazax should be used in only in an all-year-around manner in order to obtain clinical efficacy. Further, more well-designed clinical trials are needed to establish the pre and co-seasonal treatment efficacy with Grazax.

      PubDate: 2017-02-16T22:23:56Z
      DOI: 10.1016/j.alergo.2017.02.005
       
  • Bronchial allergen challenge – An old, but still useful tool in
           research and diagnostics
    • Authors: Zenon Siergiejko; Grzegorz Siergiejko; Mark Klukowski; Ewa Maria Swiebocka
      Abstract: Publication date: Available online 16 February 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Zenon Siergiejko, Grzegorz Siergiejko, Mark Klukowski, Ewa Maria Swiebocka
      A bronchial allergen challenge may serve both as a diagnostic as well as investigative procedure. Its usage in the diagnosis of asthma is infrequent due to its time-consuming nature as well as (in our opinion) an unfounded fear for a patient's safety. It is quite useful in the diagnostics of workplace related illnesses. Due to its ability to produce a controlled, long-lasting allergic-inflammatory reaction in the bronchi, this procedure is commonly used in research settings as well as in the assessment of new substances which may potentially have a place in the treatment of asthma, for ex. through the blocking of late asthmatic reactions. Changes stimulated by a bronchial allergen challenge may be evaluated by many methods using different materials, i.e. samples obtained from direct biopsies, bronchoalveolar lavages, exhaled breath condensates, or measured fractional exhaled nitric oxide. This procedure is a seemingly ideal research and diagnostic tool, however, a common protocol for its execution has not yet been accepted. Recent legal regulations have resulted in difficulties obtaining various allergens for challenge tests. Hopefully this is a temporary and minor setback for this very useful and constantly developing procedure.

      PubDate: 2017-02-16T22:23:56Z
      DOI: 10.1016/j.alergo.2017.02.004
       
  • Scaling up strategies of the chronic respiratory disease programme of the
           European Innovation Partnership on Active and Healthy Ageing – Executive
           summary
    • Authors: Th. Werfel; P. Hellings; I. Agache; A. Muraro; J. Bousquet
      Abstract: Publication date: Available online 13 February 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Th. Werfel, P. Hellings, I. Agache, A. Muraro, J. Bousquet
      Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory diseases action plan involves AIRWAYS integrated care pathways (ICPs). It is deployed in collaboration with the WHO Global Alliance against Chronic Respiratory Diseases (GARD). The EIP on AHA has proposed a 5-step framework for developing an individual scaling up strategy: (i) what to scale up: (i-a) databases of good practices, (i-b) assessment of viability of the scaling up of good practices, (i-c) classification of good practices for local replication and (ii) how to scale up: (ii-a) facilitating partnerships for scaling up, (ii-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory diseases action plan of the EIP on AHA.

      PubDate: 2017-02-16T22:23:56Z
      DOI: 10.1016/j.alergo.2017.02.002
       
  • The role and choice criteria of antihistamines in allergy management
           – Expert opinion
    • Authors: Piotr Kuna; Dariusz Jurkiewicz; Magdalena M. Czarnecka-Operacz; Rafał Pawliczak; Jarosław Woroń; Marcin Moniuszko; Andrzej Emeryk
      Abstract: Publication date: Available online 10 February 2017
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Piotr Kuna, Dariusz Jurkiewicz, Magdalena M. Czarnecka-Operacz, Rafał Pawliczak, Jarosław Woroń, Marcin Moniuszko, Andrzej Emeryk
      Allergic diseases are the most common chronic conditions lasting throughout the patient's life. They not only cause significant deterioration in the quality of life of patients but also lead to significant absenteeism and reduced productivity, resulting in very high costs for society. Effective and safe treatment of allergic diseases is therefore one of the main challenges for public health and should be carried out by all the specialists in family medicine, internists and paediatricians in collaboration with allergists, otorhinolaryngologists and dermatologists. Antihistamines are most commonly used in the treatment of allergies. Several dozen drugs are available on the pharmaceutical market, and their generic forms are advertised widely as very effective drugs for the treatment of allergic diseases. What is the truth' What are the data from clinical trials and observational studies' Are all drugs equally effective and safe for the patient' According to a panel of experts representing various fields of medicine, inappropriate treatment of allergies can be very risky for patients, and seemingly equally acting medications may differ greatly. Therefore, a panel of experts gathered the latest data from the entire scientific literature and analyzed the latest standards and recommendations prepared by scientific societies. This paper provides a summary of these studies and highlights the importance for the patient of the proper choice of drug to treat his allergies.

      PubDate: 2017-02-10T22:19:37Z
      DOI: 10.1016/j.alergo.2017.02.001
       
  • Spożywanie nieprzetworzonego mleka krowiego zapobiega najczęstszym
           zakażeniom układu oddechowego u niemowląt
    • Authors: Georg Loss; Martin Depner; Laurien H. Ulfman; R.J. Joost van Neerven; Alexander J. Hose; Jon Genuneit; Anne M. Karvonen; Anne Hyvärinen; Vincent Kaulek; Caroline Roduit; Juliane Weber; Roger Lauener; Petra Ina Pfefferle; Juha Pekkanen; Outi Vaarala; Jean-Charles Dalphin; Josef Riedler; Charlotte Braun-Fahrländer; Erika von Mutius; Markus J. Ege
      Abstract: Publication date: Available online 27 August 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Georg Loss, Martin Depner, Laurien H. Ulfman, R.J. Joost van Neerven, Alexander J. Hose, Jon Genuneit, Anne M. Karvonen, Anne Hyvärinen, Vincent Kaulek, Caroline Roduit, Juliane Weber, Roger Lauener, Petra Ina Pfefferle, Juha Pekkanen, Outi Vaarala, Jean-Charles Dalphin, Josef Riedler, Charlotte Braun-Fahrländer, Erika von Mutius, Markus J. Ege


      PubDate: 2016-08-29T16:40:27Z
      DOI: 10.1016/j.alergo.2016.08.004
       
  • Bezpieczeństwo szczepień profilaktycznych u chorych na choroby
           alergiczne
    • Authors: Olga Branicka; Joanna Glück
      Pages: 90 - 94
      Abstract: Publication date: Available online 25 August 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Olga Branicka, Joanna Glück
      Preventive vaccinations are a great achievement of the medicine. However, as all therapeutic methods, they are not devoid of adverse effects, including hypersensitivity reactions. The administration of vaccines to patients with allergic diseases, especially who are allergic to eggs is a serious concern. In this paper data on hypersensitivity to preventive vaccinations have been presented together with current recommendations for patients with allergic hypersensitivity.

      PubDate: 2016-08-29T16:40:27Z
      DOI: 10.1016/j.alergo.2016.08.003
       
  • Znaczenie wybranych swoistych przeciwciał IgE w epidemiologii
           alergicznego nieżytu nosa i astmy – program Epidemiologia Chorób
           Alergicznych w Polsce (ECAP)
    • Authors: Bolesław Samoliński; Andrzej Namysłowski; Filip Raciborski; Wojciech Zieliński; Aneta Tomaszewska; Jacek Borowicz; Piotr Samel-Kowalik; Artur Walkiewicz; Barbara Piekarska; Agnieszka Lipiec; Artur Białoszewski; Edyta Krzych-Fałta
      Pages: 102 - 107
      Abstract: Publication date: Available online 6 August 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Bolesław Samoliński, Andrzej Namysłowski, Filip Raciborski, Wojciech Zieliński, Aneta Tomaszewska, Jacek Borowicz, Piotr Samel-Kowalki, Artur Walkiewicz, Barbara Piekarska, Agnieszka Lipiec, Artur Białoszewski, Edyta Krzych-Fałta
      Introduction The research project was going to be a follow-up to epidemiological studies of allergy and asthma conducted in 9 regions of Poland, known under the acronym as ECAP (Epidemiology of Allergic Disease). Aim The aim of this project was to: a) verify the prevalence of allergies to inhaled allergens; b) determine the role of the most common allergens in allergic rhinitis and asthma. Methods The study was based on sera collected in the project ECAP. Individuals in 3 age groups (6–7 years, 13–14 years, 20–44 years) from 9 locations (8 urban and one rural) were included in the study. Specific IgE antibodies concentration was determined, using the reference method CAP, in sera of 4058 respondents. These are antibodies against main allergens responsible for the IgE-dependent allergic diseases (d1 – Dermatophagoides pteronyssinus, g6 – Phleum pratense, m6 – Alternaria alternata, e1 – cat dander). Results 24.9% of sera revealed the presence of IgE antibody levels in at least class 1 (≥0,35IU/ml) to at least one of the four analyzed allergens (d1, e1, g6, M6). Most frequent were IgE positive test results for house dust mites (d1). The lowest percentage of people with IgE antibodies to at least one of the analyzed allergens was observed in rural area of Zamojszczyzna (20.7%) and in Bialystok (21.3%). The highest percentage of positive IgE test results was achieved in Gdansk (30.7%). In the group of men, 31% have positive IgE test results to at least one of the four analyzed allergens. For women, it was 19.9%. Most frequent IgE antibodies to at least one of the analyzed allergens were observed in the group of 20–24 year old (31.9%). Similar results were obtained in the group of 13–14 year old (29.2%) and 25–29 year old (27.5%). Least frequent IgE antibodies were observed among persons aged 40–44 (17.4%). In the case of positive result of skin prick test (≥9mm) percentage of subjects with IgE antibodies oscillated from 77.8% to 96.3% depending on the allergen. In the group without asthma, IgE antibody to any analyzed allergen was found in 22.2% of cases. Among those diagnosed with asthma, it was 51.3%. In the group without allergic rhinitis, positive IgE test results for at least one of the tested allergens was obtained in 10.9% of cases. In the group with any form of AR, the percentage was 60.1%. Conclusion In the study group most frequently found positive signs of IgE in the order for house dust mite, grass pollen, cat and mold. The effect of test allergens plays an important role in the pathogenesis of AR and asthma.

      PubDate: 2016-08-09T16:16:54Z
      DOI: 10.1016/j.alergo.2016.08.001
       
  • Najmniejsze przekroje poprzeczne jamy nosa w ocenie donosowej próby
           prowokacyjnej z alergenem
    • Authors: Edyta Krzych-Fałta; Konrad Furmańczyk; Bolesław Samoliński
      Pages: 108 - 113
      Abstract: Publication date: Available online 3 September 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Edyta Krzych-Fałta, Konrad Furmańczyk, Bolesław Samoliński
      Introduction Acoustic rhinometry as a simple and non-invasive method of evaluation of nasal patency is an important tool in the diagnosis of rhinologic and allergic disorders. The aim of the study was to attempt to evaluate the reaction of the nasal mucous membrane to a topically applied allergen by the measurement of the minimum cross-sectional area of the nose (MCA1 and MCA2). The study group consisted of 60 subjects (30 patients with diagnosed allergic rhinitis and 30 healthy ones). The method that was used in the study was acoustic rhinometry (Rhinometrics, Denmark 2001) assessed in a nasal challenge test. Results In the group with allergic rhinitis, significant changes of the surface of the cross-sectional area have been observed, and were measured from the 10th minute with the most significant changes achieved at the 15th and 20th minute of the test. Definitely, more relative reactivity was observed on the right side of the nasal cavity than on the left side (-13.76±33.50 p<0,05; -14.26±28.648 p<0,05). Conclusion A response to the topically applied allergen was observed mainly in the area of the head of the inferior nasal concha as compared to the area located in the nasal vestibule.

      PubDate: 2016-09-03T16:43:41Z
      DOI: 10.1016/j.alergo.2016.08.006
       
  • Why not evaluate the allergenic potential of bee pollen with a skin
           testing method'
    • Authors: Claude Nonotte-Varly
      Pages: 114 - 122
      Abstract: Publication date: Available online 24 August 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Claude Nonotte-Varly
      Background: Bee pollen (BP) is a dangerous food for allergics because of allergenic pollens (AP). We present a method to evaluate allergenic potentials of AP in BP by using skin prick testing. Method: First, it is experimentally characterized relationship between mass of one AP (MassAP) content in BP and its allergenic potential measured by skin reactivity testing. MassAP is identified in BP mass after having calculated the proportion of AP using the BP pollinic spectrum based on the European standard. Skin reactivity to AP is assessed by measuring wheal diameters (W AP) from skin prick tests using three serial dilutions of BP on allergic patients to AP, in order to calculate equation of the relationship between MassAP and skin reactivity. Relationship equations are calculated for several AP. Then, for a BP having several AP, allergenic potentials of AP (W AP) are assessed by BP spectrum analysis, AP identifications, MassAP calculations and W AP calculations using equations. Results: Linear functions Log(W AP)= A(Log(MassAP))+ B (R 2 =0.99) were established using BP samples rich in only one genus of AP. For a polyfloral BP with different AP, W AP of each AP is proportional to MassAP included in a stated dose of BP. E.g., for a BP with 0.017mg of artemisia (A) and 0.367mg of forage grasses (FG) per mg, W A and W FG are 7.7mm and 8.9mm, respectively, for 1g of BP and 12.5mm and 13.1mm for 5g. Conclusion: This method could help to diagnose of anaphylactic accident after BP ingestion or to prevent anaphylactic risk for allergic consumers.

      PubDate: 2016-08-29T16:40:27Z
      DOI: 10.1016/j.alergo.2016.08.002
       
  • Identyfikacja nowych immunofenotypów w przypadku alergicznej i
           niealergicznej astmy u dzieci
    • Authors: Diana Raedler; Nikolaus Ballenberger; Elisabeth Klucker; Andreas Böck; Ragna Otto; Olivia Prazeres da Costa; Otto Holst; Thomas Illig; Thorsten Buch; Erika von Mutius; Bianca Schaub
      Abstract: Publication date: Available online 2 June 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Diana Raedler, Nikolaus Ballenberger, Elisabeth Klucker, Andreas Böck, Ragna Otto, Olivia Prazeres da Costa, Otto Holst, Thomas Illig, Thorsten Buch, Erika von Mutius, Bianca Schaub


      PubDate: 2016-06-07T21:40:11Z
      DOI: 10.1016/j.alergo.2016.05.001
       
  • Wybrane aspekty epidemiologiczne alergii pokarmowej wieku
           dziecięco-młodzieżowego i dorosłego
    • Authors: Maciej Kaczmarski; Zbigniew Bartuzi
      Pages: 46 - 55
      Abstract: Publication date: Available online 7 June 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Maciej Kaczmarski, Zbigniew Bartuzi
      Food allergy is a hypersensitive state of the human body in which the food consumed, which is a source of allergens, triggers immune processes (IgE-mediated, IgE-independent, or mixed) resulting in symptoms. The prevalence of food allergy in the human population shows an upward trend in the last 30–40 years as documented by epidemiological studies conducted mainly in developed countries. The reasons for this phenomenon have still not been fully explained. An important role in this upward trend is thought to be played by select environmental factors affecting the human genome. This process is called “epigenetic influence”. Epidemiological studies on the prevalence of food allergies relate to food products frequently consumed by people all over the world (milk, eggs, wheat, soy, fish, seafood, peanuts, nuts, fruits, and vegetables). The results of such studies on the incidence of allergies to these foods, however, are varied and depend on the study center. The lack of comparability between these results is chiefly caused by different methodologies applied which produce varying incidences. In this paper, the authors present a comparative analysis of the prevalence of food allergies in different countries of the world, taking into account differences in research methodology. We compared the results of past research conducted among children, adolescents, and adults, with current ongoing studies utilizing a food provocation test as an objective method confirming an etiopathogenetic allergic response to the studied food. Epidemiological studies on the incidence of food allergy in Poland have also been characterized.

      PubDate: 2016-06-07T21:40:11Z
      DOI: 10.1016/j.alergo.2016.06.001
       
  • Czy biurokracja ograniczy stosowanie immunoterapii alergenowej u
           dzieci'
    • Authors: Ewa Cichocka-Jarosz
      Pages: 56 - 60
      Abstract: Publication date: Available online 18 April 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Ewa Cichocka-Jarosz
      Guidelines (recommendations) created by scientific societies or panels of experts do not have the strength of regulations, but as they rely on current evidence based medicine, they are the source of important medical knowledge in every day practice. Guidelines should be discriminated from standards, which are legal regulations being an area of responsibility of ministry of health. Allergen immunotherapy is one of the fundamental procedures in allergology. Current national and international guidelines critically review and up-date the knowledge addressed to allergen immunotherapy. For different reasons AIT is especially beneficial for children. In the European Union registration of allergen products for both diagnostic and treatment purposes is regulated by certain directives and is subject to supervision of European Medical Agency. For the purpose of performing high quality clinical trials with allergen immunotherapy in children, pediatric investigational plan was introduced. Its high requirements create a high-risk situation which may limit introduction of AIT in pediatric population. It arises concern of medical authorities.

      PubDate: 2016-04-23T01:01:23Z
      DOI: 10.1016/j.alergo.2016.04.002
       
  • Znaczenie osoczowej acetylohydrolazy PAF w chorobach alergicznych –
           aktualny stan wiedzy
    • Authors: Krzysztof Łukasz Piwowarek; Jerzy Kruszewski
      Pages: 61 - 68
      Abstract: Publication date: Available online 16 April 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Krzysztof Łukasz Piwowarek, Jerzy Kruszewski
      Platelet activating factor (PAF) has a proven role as a mediator in pathogenesis of various disorders with inflammatory component, including those with allergic aetiology. The peripheral blood concentration of PAF is dynamically regulated by plasma PAF acetylhydrolase. An association between the enzyme activity and incidence as well as progression of numerous ailments, such as diabetes, atherosclerosis or coronary artery disease, has been demonstrated. In terms of allergic disorders those connections are underlined in case of bronchial asthma and anaphylaxis. The studies suggest that low activity of plasma PAF acetylhydrolase could be a potential predictive marker for increased severity of some types of allergic hypersensitivity reactions. The possible connections between enzyme activity and population polymorphism, levels of lipoprotein fractions, applied pharmacotherapy and chronic disorders of different aetiology appear to be also interesting within the context of allergic diseases. The aim of the following review is to systematize the current state of knowledge regarding possible importance and utilization of platelet activating factor acetylhydrolase measurement for the needs of allergology.

      PubDate: 2016-04-18T00:34:38Z
      DOI: 10.1016/j.alergo.2016.04.003
       
  • Badanie USG przezklatkowe w ręku alergologa. Podstawy przezklatkowego
           badania USG
    • Authors: Małgorzata Michalczuk; Anna Chudoba; Adam J. Sybilski
      Pages: 69 - 74
      Abstract: Publication date: Available online 16 April 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Małgorzata Michalczuk, Anna Chudoba, Adam J. Sybilski
      Transthoracic lung ultrasound (TLU) is a non-invasive and easily accessible method for diagnosing diseases of the pleura and lung. No ionizing radiation allows its use in people with diseases such as Nijmegen breakage syndrome (NBS) or pregnant women. Possibility of repeated studies allows to monitoring therapy. The method uses the artifacts caused by changes out to the periphery of the lungs. Visualization of specific artifacts in lung ultrasound in conjunction with the medial examination often allows the correct diagnosis. In addition, the sensitivity and specificity of TLU are often comparable to the radiological examination and computed tomography. Another advantage is the availability and the short duration of the study which is important in emergency cases. The article presents study techniques and basic artifacts evaluated in TLU. Proper pleural line is characterized by equal outlines, without irregularities. The movement of the pleura is called “lung sliping sign”. Acoustic shadows of two adjacent ribs and pleural line form the so-called “bat sign”. The main artifacts assessed in TLU include artifacts line A, line B and line Z.

      PubDate: 2016-04-18T00:34:38Z
      DOI: 10.1016/j.alergo.2016.04.001
       
  • Porównanie częstości występowania astmy i chorób alergicznych oraz
           czynników ich rozwoju w zależności od miejsca zamieszkania w
           województwie pomorskim
    • Authors: Marlena Sztormowska; Piotr Skonieczny; Marek Niedoszytko; Marta Chełmińska; Ewa Jassem
      Pages: 79 - 83
      Abstract: Publication date: Available online 11 June 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Marlena Sztormowska, Piotr Skonieczny, Marek Niedoszytko, Marta Chełmińska, Ewa Jassem
      Introduction The studies on the epidemiology of allergic diseases indicate at the difference in prevalence depending on the place of residence. The study Epidemiology Allergic Diseases in Poland (ECAP) showed that citizens have a higher prevalence of asthma and allergic diseases. Research compared the major Polish cities and rural areas of Zamojszczyzna. Observations of patients living in Pomeranian region suggest to the mixed character of the rural Pomeranian area and similar prevalence as in the Tri-City agglomeration. Aim The aim of the study was to determine the prevalence of diseases (asthma, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, urticaria, food allergies, allergy to insect venom and drugs) in the population of the province of Pomerania, among patients living in the city and countryside. The second objective was to evaluate the significance of the factors predisposing to the development of asthma and allergy (sex, smoking, having a bird or cat, housing conditions). Methods The analysis was based on the research questionnaire containing questions used in epidemiological studies ISAC, ECHRS, ECAP constructed for the study. Statistical analysis of the collected results was made in the program Statistica v.12, χ2 test. The research group consisted of 619 people – 457 women and 162 men, 180 residents of villages and 439 urban residents. Results A statistically significant difference and a higher incidence were found in patients with food allergies (p=0.0002); urticaria (p=0.009); atopic dermatitis (p=0.0025); allergies to drugs (p=0.0001). There were no differences in the prevalence, depending on the place of residence, of asthma (p=0.5), allergic rhinitis (p=0.056), allergic conjunctivitis (p=0.33), allergic reactions to insect venom (p=0.13), smoking (p=0.1), sex (p=0.054). More frequent development of asthma was observed in patients treated for allergic rhinitis OR=4.29 (CI 1.02–18.03). The differences in the prevalence of the risk factors such as smoking, having a bird or a cat, and the living conditions were statistically insignificant. Conclusions The prevalence of the risk factors of allergic diseases as well as asthma, allergic rhinitis and drug allergies were similar in urban and rural areas. The prevalence of food and drug allergy, urticarial and atopic dermatitis were higher among the residences of the cities.

      PubDate: 2016-06-13T22:55:25Z
      DOI: 10.1016/j.alergo.2016.06.003
       
  • Maski astmy oskrzelowej – opis przypadku
    • Authors: Maciej Kupczyk; Piotr Kuna
      Pages: 84 - 87
      Abstract: Publication date: Available online 11 March 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Maciej Kupczyk, Piotr Kuna
      Severe, difficult-to-treat asthma represents a significant burden for the patient and the health system. In difficult-to-treat asthma, factors worsening asthma control may include: inadequate treatment plan (low therapy adherence and compliance), inappropriate inhalation technique, insufficient symptom control using the available classes of medications, incomplete response to treatment (non-responders, steroid-resistance), incorrect diagnosis of asthma or comorbidities, and environmental factors. In difficult asthma it is recommended to perform detailed diagnostics and initiate treatment of concomitant diseases, carry out differential diagnostics of conditions mimicking asthma, educate the patient as to the inhalation technique and check it, eliminate unfavorable environmental factors before current treatment is modified. We described here a case of 30-year-old woman, followed for 4 years in a specialist center, with the diagnosis of severe asthma, frequent exacerbations, hospitalizations, significant changes in lung functions, referred to be included in the program of biologic treatment that came out as tumor of the trachea.

      PubDate: 2016-03-14T20:35:21Z
      DOI: 10.1016/j.alergo.2016.03.003
       
  • Od Redaktora Naczelnego
    • Authors: Rafał Pawliczak
      First page: 1
      Abstract: Publication date: Available online 5 September 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Rafał Pawliczak


      PubDate: 2016-09-09T16:48:05Z
      DOI: 10.1016/j.alergo.2016.03.001
       
  • Od Redaktora Naczelnego
    • Authors: Rafał Pawliczak
      First page: 1
      Abstract: Publication date: Available online 7 June 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Rafał Pawliczak


      PubDate: 2016-06-07T21:40:11Z
      DOI: 10.1016/j.alergo.2016.03.001
       
  • Od Redaktora Naczelnego
    • Authors: Rafał Pawliczak
      First page: 1
      Abstract: Publication date: Available online 4 March 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Rafał Pawliczak


      PubDate: 2016-03-09T19:32:03Z
      DOI: 10.1016/j.alergo.2016.03.001
       
  • Epidemiologia i przebieg naturalny alergii na zwierzęta futerkowe
    • Authors: Natalia Ukleja-Sokołowska; Zbigniew Bartuzi
      Pages: 2 - 8
      Abstract: Publication date: Available online 23 February 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Natalia Ukleja-Sokołowska, Zbigniew Bartuzi
      Researchers agree that the incidence of allergy to pets in Europe and the United States is growing for several decades. The incidence of allergy to dog and cat varies depending on the chosen population, age and sex. The number of pets in the environment makes it difficult to avoid contact with them. Allergens can be transferred on clothes of pet owners to places where theoretically we do not expect animals, and dog and cat allergens remain in the air for a very long time, after an animal left the environment. In the publications conflicting reports can be found about the impact of childhood exposure to animal allergens on allergy later in the life of a child. The test results may be affected by the choice of the examined group and the objective difficulties in comparing pet owners to people who do not have any animals at home. Researchers proved that people who are allergic to dog or cat are more susceptible of sensitization to other fur-bearing animals than patients with inhaled allergy, but not sensitized to dog or cat allergens. Furthermore, the lack of direct contact with the animal does not rule out allergies, which may indicate either a cross-reaction or an individual's susceptibility to animal dander allergies.

      PubDate: 2016-02-26T08:58:44Z
      DOI: 10.1016/j.alergo.2016.02.003
       
  • Effectiveness of omalizumab therapy in patients with highly severe
           allergic asthma treated in Department of Pulmonology in Krakow
    • Authors: Agnieszka Gawlewicz-Mroczka; Weronika Zastrzeżyńska; Marek Przybyszowski; Adam Cmiel; Krzysztof Sładek
      Abstract: Publication date: Available online 2 December 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Agnieszka Gawlewicz-Mroczka, Weronika Zastrzeżyńska, Marek Przybyszowski, Adam Cmiel, Krzysztof Sładek
      Immunoglobulin E plays an important role in allergic diseases. In patients with allergic asthma, exposure to allergens releases a wide range of proinflamatory mediators, which are responsible for acute and chronic symptoms of the disease. IgE has become an attractive target in allergic asthma. In 2006, in Europe omalizumab became available. Objectives Our knowledge of who will derive the highest benefit from omalizumab therapy is still limited. The aim of this study was to evaluate the efficacy of omalizumab during one year of therapy carried out under real-life conditions in Polish patients with severe allergic asthma. We also attempted to identify predictors for very good responses to treatment. Methods We enrolled 15 patients due to inclusion criteria of the program for severe allergic asthma funded by the National Health Insurance. All the patients were assessed for asthma control, quality of life, daily dose of oral and inhaled corticosteroids, asthma exacerbation rate, and lung function. The effectiveness of the treatment was analyzed after 16 weeks and one year following the inclusion each patient to the therapy. The patients were divided into two groups according to their response to the treatment: very good and good, based on the GETE scale. Results Omalizumab decreased the severity of symptoms, improved asthma control and quality of life in patients. It helped to reduce episodes of asthma exacerbation and the use of systemic corticosteroids. At present, the overall assessment by physicians is still the best and most reliable method of identifying responders to the omalizumab therapy.

      PubDate: 2016-12-06T21:37:48Z
      DOI: 10.1016/j.alergo.2016.11.010
       
  • Zespół alergii jamy ustnej (zespół pyłkowo-pokarmowy), anafilaksja i
           alergologia molekularna. Nowe endotypy, nowe horyzonty
    • Authors: Łukasz Błażowski; Katarzyna Gregorczyk-Maślanka; Ryszard Kurzawa
      Abstract: Publication date: Available online 1 December 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Łukasz Błażowski, Katarzyna Gregorczyk-Maślanka, Ryszard Kurzawa
      The main symptoms of oral allergy syndrome (OAS) usually involve oral cavity, but in the case of pollen food syndrome (PFS), symptoms may lead to development of systemic reactions. Precise diagnostics of primary sensitizer and triggering symptoms allow to give proper recommendations for the patient, which are crucial for diminishing the risk of anaphylaxis. Based on the case of a 12-year-old patient, the rules of component-resolved diagnostics and the benefits of PFS endotypes identification were discussed.

      PubDate: 2016-12-06T21:37:48Z
      DOI: 10.1016/j.alergo.2016.11.008
       
  • Od Redaktora Naczelnego
    • Authors: Rafał Pawliczak
      Abstract: Publication date: Available online 1 December 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Rafał Pawliczak


      PubDate: 2016-12-06T21:37:48Z
      DOI: 10.1016/j.alergo.2016.11.004
       
  • Nadwrażliwość na diazepam (Relanium)
    • Authors: Michał Abramowicz; Jerzy Kruszewski
      Abstract: Publication date: Available online 1 December 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Michał Abramowicz, Jerzy Kruszewski
      Diazepam – a benzodiazepine derivative is a quite commonly administered drug. Despite a fairly long list of diazepam's common side effects, hypersensitivity to this drug including anaphylactic shock almost does not occur. The paper presents a case of 60-year-old patient after a documented anaphylactic shock. The suggested cause was an intravenous administration of diazepam during the induction of anesthesia for the planned surgery. During the hospitalization, hypersensitivity to diazepam was confirmed by positive reactions in intradermal tests with diazepam.

      PubDate: 2016-12-06T21:37:48Z
      DOI: 10.1016/j.alergo.2016.11.007
       
  • Wpływ spożywania orzeszków ziemnych w badaniu LEAP: wykonalność,
           rozwój fizyczny i stan odżywienia
    • Authors: Mary Feeney; George Du Toit; Graham Roberts; Peter H. Sayre; Kaitie Lawson; Henry T. Bahnson; Michelle L. Sever; Suzana Radulovic; Marshall Plaut; Gideon Lack
      Abstract: Publication date: Available online 25 November 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Mary Feeney, George Du Toit, Graham Roberts, Peter H. Sayre, Kaitie Lawson, Henry T. Bahnson, Michelle L. Sever, Suzana Radulovic, Marshall Plaut, Gideon Lack
      Graphical abstract image

      PubDate: 2016-11-29T10:10:54Z
      DOI: 10.1016/j.alergo.2016.11.006
       
  • Omalizumab – standard terapii w astmie ciężkiej, przyszłość terapii
           w przewlekłej pokrzywce
    • Authors: Rafał Pawliczak
      Abstract: Publication date: Available online 17 November 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Rafał Pawliczak
      Omalizumab was introduced in the therapy regime of severe asthma treatment more than a decade ago. Nowadays, it is considered the gold standard to treat severe, allergic asthma. It allows patients to live normal, productive life, with significantly reduced number of asthma exacerbations, fewer parenteral glucocorticosteroid pulses, and reduced episodes of hospitalizations. Moreover, it is successfully employed in chronic urticaria treatment. In this short review, we summarize the importance of severe asthma diagnosis, the role of omalizumab in treatment of severe asthma, and the mechanism of action of omalizumab. The mechanism of action of omalizumab in chronic urticaria treatment remains to be fully elucidated. This paper is an introduction to the case series presented in this supplement.

      PubDate: 2016-11-21T17:38:47Z
      DOI: 10.1016/j.alergo.2016.11.005
       
  • Skład mikrobiomu jelit we wczesnym okresie życia a ustępowanie alergii
           na białka mleka
    • Authors: Supinda Bunyavanich; Nan Shen; Alexander Grishin; Robert Wood; Wesley Burks; Peter Dawson; Stacie M. Jones; Donald Y.M. Leung; Hugh Sampson; Scott Sicherer; Jose C. Clemente
      Abstract: Publication date: Available online 16 November 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Supinda Bunyavanich, Nan Shen, Alexander Grishin, Robert Wood, Wesley Burks, Peter Dawson, Stacie M. Jones, Donald Y.M. Leung, Hugh Sampson, Scott Sicherer, Jose C. Clemente


      PubDate: 2016-11-21T17:38:47Z
      DOI: 10.1016/j.alergo.2016.11.003
       
  • Od Redaktora Naczelnego
    • Authors: Rafał Pawliczak
      Abstract: Publication date: Available online 16 November 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Rafał Pawliczak


      PubDate: 2016-11-21T17:38:47Z
      DOI: 10.1016/j.alergo.2016.11.004
       
  • 23-letnia chora na astmę oskrzelową z utrwalonymi zaburzeniami
           wentylacji ciężkiego stopnia
    • Authors: Farnik
      Abstract: Publication date: Available online 9 November 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Małgorzata Farnik
      A 23-year-old female reported with atopic asthma and allergic rhinitis diagnosed in childhood, and complaints of frequent exacerbations since adolescence. Spirometry showed gradual progression of obstruction – at the age of 20 – representing very severe obturation. The patient never smoked and had no exposition to any potential irritation factors. Due to frequent exacerbations, the patient often required systemic glucocorticoids; at the age of 21, she was diagnosed with TB. After the antituberculosis treatment was completed, reversibility test was negative, and slow progression of obstruction was still observed (FEV1 20% of predicted value). The patient had presented depression symptoms. She was qualified for anti-IgE treatment; after 8 months, clinically significant improvement was observed – the number of exacerbations was reduced and systemic GCS has been stopped. Spirometry had showed improvement with FEV1 – 38% of predicted. As the exercise tolerance improved, the patient has resumed her academic studies.

      PubDate: 2016-11-14T17:34:14Z
       
  • Astma ciężka – leczenie biologiczne omalizumabem –
           opis przypadku
    • Authors: Grzegorz Osmenda; Barbara Jasiewicz-Honkisz
      Abstract: Publication date: Available online 8 November 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Grzegorz Osmenda, Barbara Jasiewicz-Honkisz
      A patient with long-lasting atopic asthma, allergic rhinitis, chronic idiopathic urticaria, decreased lung function, complaints of recurrent day and night symptoms, and exacerbations that need systemic GKS often visits the ER departments. During chronic treatment, the patient used a large dose of GKS and LABA, which were inhaled. The patient's condition changed after initiating treatment with omalizumab. We achieved clinical improvement, confirmed by the spirometry results, and reduction of intensity of asthma and urticaria with treatment.

      PubDate: 2016-11-08T17:28:59Z
      DOI: 10.1016/j.alergo.2016.11.001
       
  • Pokrzywka przewlekła u chorej na ciężką astmę atopową – podwójna
           korzyść z leczenia omalizumabem
    • Authors: Joanna Goździk-Spychalska; Małgorzata Rzymkowska; Halina Batura-Gabryel
      Abstract: Publication date: Available online 3 November 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Joanna Goździk-Spychalska, Małgorzata Rzymkowska, Halina Batura-Gabryel
      Urticaria is one of the most common skin disorders. A characteristic feature of this disease is the sudden appearance and rapid regression (up to 24hours) of blisters, angioedema, or both of these simultaneously. Often, the above changes are accompanied by symptoms of itching and pain. Chronic urticaria, i.e. one that lasts for at least 6 weeks, is divided into spontaneous (CSU) and induced. CSU, because of its unpredictable nature, strongly reduces the quality of life, especially the patient's active professionally and socially. Below is a description of a 38-year-old female patient, with the profession of teacher diagnosed with atopic chronic severe asthma coexisting with CSU, which has been qualified for the program with omalizumab in 2013, i.e., one year before the registration of the drug in the latter diagnosis. Since the inclusion of the patient into the program in addition to the vast improvement in asthma control in spite of the withdrawal of systemic corticosteroids (sGCS) and the reduction of inhaled glucocorticosteroids (ICS), any episode of CSU is not repeated which is undoubtedly the added benefit of applied therapy.

      PubDate: 2016-11-08T17:28:59Z
      DOI: 10.1016/j.alergo.2016.10.001
       
  • Pacjentka z ciężką astmą wyłączona z leczenia omalizumabem po 12
           tygodniach
    • Authors: Agnieszka Gawlewicz-Mroczka; Marek Przybyszowski; Weronika Zastrzeżyńska; Krzysztof Sładek
      Abstract: Publication date: Available online 3 November 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Agnieszka Gawlewicz-Mroczka, Marek Przybyszowski, Weronika Zastrzeżyńska, Krzysztof Sładek
      We present the case of 20-year-old woman with the short history of severe course of asthma since its beginning. The patient met the inclusion criteria to omalizumab therapy in the program reimbursed by Polish Health Fund, so we expected that this therapy will enable to improve asthma control in the patient and decrease the dose of oral steroids or completely withdraw them. However within twelve weeks of therapy, the day of omalizumab application had to be rescheduled many times because of infectious asthma exacerbations. Moreover, in between exacerbations, asthma remained uncontrolled in spite of the very high doses of inhaled steroids and bronchodilators. Only on the day of last omalizumab injection, the patient reported better condition, and we observed improvement in spirometry and questionnaires score. We hoped that patient started to respond to the therapy. In the twelfth week of therapy, the patient reported that she became pregnant and had to be excluded from the therapeutical program. From the patients’ findings, high eosinophil count in peripheral blood as well as in broncho-alveolar lavage fluid were remarkable and chronic sinusitis preceded asthma diagnose.

      PubDate: 2016-11-08T17:28:59Z
      DOI: 10.1016/j.alergo.2016.10.002
       
  • Korzyści z leczenia omalizumabem wykraczające poza spodziewane efekty u
           38-letniej chorej na ciężką postać astmy alergicznej
    • Authors: Andrzej Obojski; Paulina Wełna; Robert Pawłowicz
      Abstract: Publication date: Available online 3 November 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Andrzej Obojski, Paulina Wełna, Robert Pawłowicz
      We report the case of a 38-year-old woman suffering from allergic asthma since the age of 4. In the last 10 years, the patient presented with severe uncontrolled asthma with frequent exacerbations, despite stage-5 treatment according to GINA guidelines, including constant high doses of methylprednisolone. Long-time treatment with high doses of systemic corticosteroids induced many side effects including arterial hypertension, diabetes, GERD, hypercholesterolemia and obesity (weight 121kg, height 176cm, BMI 39kg/m2). Despite the treatment, asthma control remained poor, and quality of life and lung function test results were low (ACQ: 4,71 p, miniAQLQ: 3,2 p, FEV1 2,04 L 60,3% pred., FEV1/FVC 60,85%). The patient was enrolled into the omalizumab treatment program in March 2014. After 24 months of omalizumab treatment, the dose of methylprednisolone was reduced by 30mg/day. At the same time, asthma control and quality of life improved significantly (ACQ 1,85, miniAQLQ 4,73). Body weight was reduced by 30kg (BMI 29kg/m2) as well. Asthma exacerbation rate was also significantly reduced, and there was no asthma exacerbation in the last 12 months of the treatment. Unexpectedly, we observed improvement and further normalization of spirometry with finally normal FEV1/FVC ratio and FEV1 (FEV1 2,87 L 86,4% pred.). The patient has resumed her all daily-life activities.

      PubDate: 2016-11-08T17:28:59Z
      DOI: 10.1016/j.alergo.2016.10.007
       
  • Astma prurigo
    • Authors: Jacek Gocki; Krystyna Romańska-Gocka; Zbigniew Bartuzi
      Abstract: Publication date: Available online 3 November 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Jacek Gocki, Krystyna Romańska-Gocka, Zbigniew Bartuzi
      The term asthma prurigo defines the cases of coexistence of asthma and atopic dermatitis (AD). Patients with the combination of these two disease entities are still difficult to treat despite the significant advances in medicine. The described case of a patient showed that treatment with anti-IgE has the ability not only to fully control the symptoms of asthma, but also to gain control of troublesome symptoms for patients of atopic dermatitis, leading to a complete resolution changes on the skin.

      PubDate: 2016-11-08T17:28:59Z
      DOI: 10.1016/j.alergo.2016.10.003
       
  • Terapia omalizumabem u pacjentki z ciężką eozynofilową astmą
           alergiczną i bólem stawów występującym podczas terapii – opis
           przypadku
    • Authors: Marek Przybyszowski; Agnieszka Gawlewicz-Mroczka; Weronika Zastrzeżyńska; Krzysztof Sładek
      Abstract: Publication date: Available online 3 November 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Marek Przybyszowski, Agnieszka Gawlewicz-Mroczka, Weronika Zastrzeżyńska, Krzysztof Sładek
      Implementation of omalizumab in the treatment of patients with severe allergic asthma opened the possibility of obtaining optimal control of the disease and improving the quality of life. We present a case of a patient with severe allergic asthma qualified to biological treatment with omalizumab. Before qualification, the patient suffered from numerous severe exacerbations and uncontrolled asthma symptoms, despite treatment with high doses of inhaled medications and systemic corticosteroids. After 2 years of biological therapy, we achieved a significant, but incomplete improvement in asthma control, a marked improvement in the quality of life, and a decrease in the number of exacerbations. We observed persistent elevation of eosinophilia in peripheral blood and bronchoalveolar lavage, despite treatment with anti-IgE and systemic corticosteroids, indicating eosinophil phenotype of severe asthma. Moreover, in the course of therapy, the patient reported joint symptoms of unknown origin, which after further testing were eventually attributed to post-steroid complications and osteoarthritis. In appropriately qualified patients, treatment with omalizumab gives hope for significant improvement in asthma control. The development of new biological agents will allow individualizing asthma treatment depending on asthma phenotype and endotype.

      PubDate: 2016-11-08T17:28:59Z
      DOI: 10.1016/j.alergo.2016.10.006
       
  • Radykalna poprawa kontroli astmy oskrzelowej po włączeniu do leczenia
           omalizumabu – opis przypadku
    • Authors: Aleksandra Chudzicka; Renata Rożyńska; Adam Wesołowski
      Abstract: Publication date: Available online 3 November 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Aleksandra Chudzicka, Renata Rożyńska, Adam Wesołowski
      Asthma is an important medical, social and economical problem. 5–10% of all patients with asthma constitute cases of severe asthma. One treatment method for severe asthma includes omalizumab. Its efficacy was acknowledged in many studies. We present a case of radical improvement of asthma control after omalizumab addition. It constitutes affirmation of drug efficacy.

      PubDate: 2016-11-08T17:28:59Z
      DOI: 10.1016/j.alergo.2016.10.005
       
  • Skuteczne leczenia omalizumabem chorej na ciężką astmę alergiczną z
           utrzymującą się łagodną eozynofilią krwi obwodowej
    • Authors: Joanna Hermanowicz-Salamon; Renata Rubinsztajn
      Abstract: Publication date: Available online 3 November 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Joanna Hermanowicz-Salamon, Renata Rubinsztajn
      A 46-year-old, non-smoking woman, treated for 18 years for allergic asthma associated with chronic sinusitis after bilateral ethmoidectomy in 02.2013, treated for hypertension and after cataract surgery in 2010 permanently treated with glucocorticosteroid treatment, was qualified for omalizumab treatment. She started therapy in March 2014. Despite oral glucocorticosteroids therapy (methylprednisolone 32– 4mg per day), blood eosinophil count remained high. In 16th and 52nd weeks of treatment, the effectiveness of omalizumab was assessed. Symptoms of asthma decreased which were expressed in ACQ and AQLQ along with an improvement in pulmonary function tests, associated with the reduction of daily oral glucocorticosteroids. Regardless of the improvement of asthma symptoms, mild blood eosinophilia was observed. In concomitance of severe asthma. inadequately controlled sinusitis and skin lesion EGPA were taken into account as reasons of all symptoms. EGPA was not confirmed in this patient, and mild eosinophilia was regarded as a phenotypic feature of asthma in this patient.

      PubDate: 2016-11-08T17:28:59Z
      DOI: 10.1016/j.alergo.2016.10.004
       
  • Nadwrażliwość na dodatki do żywności
    • Authors: Krzysztof
      Abstract: Publication date: Available online 3 September 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Krzysztof Buczyłko
      Contrary to common belief, the prevalence of the hypersensitivity to food additives (FAD) in the general population is rather low. Actually, there are worse things to fear than FAD. Many E number additives are completely harmless. Reactions to FAD should be suspected in patients who report symptoms to multiple unrelated foods or to a certain food when commercially prepared but not when homemade, and the allergy evaluation rules out a role for food protein. Diagnostics: there are no validated skin testing protocols for additives. The diagnosis of FAD hypersensitivity has to be confirmed objectively by double-blind placebo-controlled studies. The therapeutic approach consists in the exclusion of foods and products containing the additive involved, and, in patients not compliant to the diet, in treatment with symptomatic drugs. FAD appears to be a rare cause of allergic rhinitis, asthma, chronic idiopathic urticaria or atopic dermatitis, and avoidance is not recommended, except in the hypersensitive people (1–2%).

      PubDate: 2016-09-03T16:43:41Z
       
  • 50 lat IgE
    • Authors: Robert Kruszewski; Jerzy Kruszewski
      Abstract: Publication date: Available online 16 April 2016
      Source:Alergologia Polska - Polish Journal of Allergology
      Author(s): Robert Kruszewski, Jerzy Kruszewski
      The discovery of IgE was a major breakthrough in the development of allergology as a medical discipline. Exactly fifty years ago two independent research teams in USA and Sweden investigated and explained the role of unknown factor called reagin in allergic hypersensitivity. Provided evidence suggested that reagins are immunoglobulins of a new class. Further research of IgE properties significantly improved our understanding of the mechanism of allergic reaction. Current diagnostic and therapy of allergic diseases are largely based on these findings.

      PubDate: 2016-04-18T00:34:38Z
       
 
 
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