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Publisher: Elsevier   (Total: 3031 journals)

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Showing 1 - 200 of 3031 Journals sorted alphabetically
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 20, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 16, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 79, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 22, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 27, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 4)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 5, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 302, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 3)
Acta Biomaterialia     Hybrid Journal   (Followers: 25, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription  
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 195, SJR: 3.683, h-index: 202)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.615, h-index: 21)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 9, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription   (Followers: 1)
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 3, SJR: 0.311, h-index: 16)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 2)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 21, SJR: 1.365, h-index: 73)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 5, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 4)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.383, h-index: 19)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 2)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 5, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 4, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 4)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 5)
Additive Manufacturing     Hybrid Journal   (Followers: 7, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 20)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 119, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 16, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 8, SJR: 0.299, h-index: 15)
Advances in Agronomy     Full-text available via subscription   (Followers: 15, SJR: 2.071, h-index: 82)
Advances in Anesthesia     Full-text available via subscription   (Followers: 24, SJR: 0.169, h-index: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 3)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 6, SJR: 1.054, h-index: 35)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 10, SJR: 0.801, h-index: 26)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 21, SJR: 1.286, h-index: 49)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
Advances in Botanical Research     Full-text available via subscription   (Followers: 3, SJR: 0.619, h-index: 48)
Advances in Cancer Research     Full-text available via subscription   (Followers: 26, SJR: 2.215, h-index: 78)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 0.9, h-index: 30)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 2.139, h-index: 42)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 24, SJR: 0.183, h-index: 23)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 8, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 16, SJR: 0.223, h-index: 22)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 11)
Advances in Digestive Medicine     Open Access   (Followers: 4)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Ecological Research     Full-text available via subscription   (Followers: 39, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 25, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 7)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 38, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 3)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 41, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 14)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 18, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.497, h-index: 31)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 22)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 33, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 3, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 4)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 4)
Advances in Life Course Research     Hybrid Journal   (Followers: 7, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 8)
Advances in Marine Biology     Full-text available via subscription   (Followers: 16, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 5, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 21)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 10)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 6, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 3)
Advances in Oncobiology     Full-text available via subscription   (Followers: 3)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 20, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 14)
Advances in Pharmacology     Full-text available via subscription   (Followers: 13, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 7, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 4)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 17, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 56)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 1, SJR: 0.1, h-index: 2)
Advances in Space Research     Full-text available via subscription   (Followers: 332, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 7)
Advances in Surgery     Full-text available via subscription   (Followers: 6, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 28, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 14)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 12)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 42, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 5, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 303, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 4, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 7, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 389, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 29, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 36, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access  
Agriculture and Natural Resources     Open Access   (Followers: 1)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 48, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 3, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 9, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 5)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access  
Algal Research     Partially Free   (Followers: 7, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 5, SJR: 0.776, h-index: 35)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 6, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 45, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 5)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 3)
American Heart J.     Hybrid Journal   (Followers: 45, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 47, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 34, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 6, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 32, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 25, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 31, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 48, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 173, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 51, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 2)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 22, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 23, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 21, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 32, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 13, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 5)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 52, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 3)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 2, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 38, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 152, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 7, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 10)
Anesthésie & Réanimation     Full-text available via subscription  
Anesthesiology Clinics     Full-text available via subscription   (Followers: 21, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access  
Animal Behaviour     Hybrid Journal   (Followers: 141, SJR: 1.907, h-index: 126)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 5, SJR: 1.151, h-index: 83)
Animal Reproduction Science     Hybrid Journal   (Followers: 5, SJR: 0.711, h-index: 78)
Annales d'Endocrinologie     Full-text available via subscription   (SJR: 0.394, h-index: 30)
Annales d'Urologie     Full-text available via subscription  
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (SJR: 0.177, h-index: 13)
Annales de Chirurgie de la Main et du Membre Supérieur     Full-text available via subscription  
Annales de Chirurgie Plastique Esthétique     Full-text available via subscription   (Followers: 2, SJR: 0.354, h-index: 22)
Annales de Chirurgie Vasculaire     Full-text available via subscription   (Followers: 1)

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Journal Cover Advances in Digestive Medicine
  [4 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2351-9797
   Published by Elsevier Homepage  [3031 journals]
  • Toward more accurate endoscopic diagnosis of colorectal neoplasm:
           Balancing between innovation and applicability

    • Authors: Han-Mo Chiu
      Pages: 151 - 152
      Abstract: Publication date: December 2016
      Source:Advances in Digestive Medicine, Volume 3, Issue 4
      Author(s): Han-Mo Chiu


      PubDate: 2016-12-21T03:46:44Z
      DOI: 10.1016/j.aidm.2016.11.001
       
  • Higher net change of index of hemoglobin values between colon polyp and
           

    • Authors: Wei-Chun Cheng; Hsiu-Chi Cheng; Po-Jun Chen; Jui-Wen Kang; Er-Hsiang Yang; Bor-Shyang Sheu; Wei-Ying Chen
      Pages: 161 - 166
      Abstract: Publication date: December 2016
      Source:Advances in Digestive Medicine, Volume 3, Issue 4
      Author(s): Wei-Chun Cheng, Hsiu-Chi Cheng, Po-Jun Chen, Jui-Wen Kang, Er-Hsiang Yang, Bor-Shyang Sheu, Wei-Ying Chen
      Background The index of hemoglobin (IHb) has not been applied in colonoscopy to correlate the histological features of colon polyps. This study tested whether the net change of IHb values between polyp and normal mucosa correlates with the pathological features of colon polyps. Patients and methods This study consecutively enrolled patients who underwent colonoscopy during September 2011–August 2012 in a single tertiary referral colorectal unit. Endoscopic pictures and IHb values of each part of the colon were taken at the levels of cecum, ascending colon, transverse colon, sigmoid colon, and rectum. The net change of IHb values was calculated as follows: IHb value of colon polyp minus that of the surrounding mucosa. Results A total of 117 patients (32 with hyperplastic polyp, 5 with sessile serrated adenoma, 53 with tubular adenoma, 10 with villotubular adenoma, and 3 with adenocarcinoma) were recruited. The net change of IHb values increased in following order: hyperplastic polyp, tubular adenoma, sessile serrated adenoma, villotubular adenoma, and adenocarcinoma (−3.8 ± 6.3, −1.2 ± 1.7, −1.2 ± 5.7, 2.9 ± 8.1, and 12.7 ± 9.3, respectively; p < 0.001). Alcohol drinking and serum hemoglobin level were two independent factors related to the IHb values of non-polyp colon mucosa. Using a cutoff value of 2.4 for the net change of IHb values, selected based on the receiver operating characteristic curve analysis, the optimal sensitivity (52.9%) and specificity (75.6%) could be achieved for defining the polyp histology as an advanced colon lesion. Conclusion The net change of IHb values between colon polyp and nonpolyp mucosa can correlate with the pathological features of colon polyps. A positive net change of IHb values may indicate a more adverse histological pattern with a higher malignant potential.

      PubDate: 2016-12-21T03:46:44Z
      DOI: 10.1016/j.aidm.2015.04.005
       
  • Endoscopic balloon-based radiofrequency ablation for long-segment early
           esophageal squamous cell neoplasia

    • Authors: Ying-Nan Tsai; Ching-Tai Lee; Tao-Qian Tang; I-Wei Chang; Chi-Yang Chang; Lein-Ray Mo; Wen-Lun Wang
      Pages: 187 - 190
      Abstract: Publication date: December 2016
      Source:Advances in Digestive Medicine, Volume 3, Issue 4
      Author(s): Ying-Nan Tsai, Ching-Tai Lee, Tao-Qian Tang, I-Wei Chang, Chi-Yang Chang, Lein-Ray Mo, Wen-Lun Wang
      Esophageal cancer is a common and highly lethal disease. In the Asia-Pacific region, esophageal squamous cell neoplasias are the major forms of the disease. Recent advances in endoscopic therapy enable curative treatment of early esophageal squamous cell neoplasias, however, the technique is complicated and requires a high level of expertise, especially for those with long-segment lesions. Endoscopic radiofrequency ablation is a rapidly evolving treatment modality and has been shown to have good efficacy and safety for the treatment of dysplasia in cases of Barrett’s esophagus. Theoretically, it can also be used to treat squamous dysplasia. We report a case of a 48-year-old man with an 8-cm-long circumferential squamous high-grade dysplasia over the esophagus (from 21 cm to 29 cm below the incisor) that was treated successfully and safely with balloon-based radiofrequency ablation. The procedure took only around 30 minutes to complete. There were no major adverse events during and after the procedure. In addition, we examined the histology of the esophageal coagulum, which showed an extensive cauterization effect with focal dysplasia within the ablated epithelium. Follow-up endoscopy at 1 month, 3 months, and 6 months showed no residual lesion, and biopsies also confirmed complete remission.

      PubDate: 2016-12-21T03:46:44Z
      DOI: 10.1016/j.aidm.2015.04.007
       
  • Altered circadian rhythm, sleep disturbance, and gastrointestinal
           dysfunction: New evidence from rotating shift workers

    • Authors: Ping-Huei Tseng; Ming-Shiang Wu
      Pages: 77 - 79
      Abstract: Publication date: Available online 4 June 2016
      Source:Advances in Digestive Medicine
      Author(s): Ping-Huei Tseng, Ming-Shiang Wu


      PubDate: 2016-06-07T12:20:46Z
      DOI: 10.1016/j.aidm.2016.05.001
       
  • Altered anorectal function in rotating shift workers: Association with
           autonomic dysfunction and sleep disturbance

    • Authors: Jui-Sheng Hung; Tso-Tsai Liu; Chih-Hsun Yi; Wei-Yi Lei; Chien-Lin Chen
      Pages: 80 - 87
      Abstract: Publication date: September 2016
      Source:Advances in Digestive Medicine, Volume 3, Issue 3
      Author(s): Jui-Sheng Hung, Tso-Tsai Liu, Chih-Hsun Yi, Wei-Yi Lei, Chien-Lin Chen
      Background We aimed to investigate whether disruption of the circadian rhythm in rotating shift work (RSW) workers would change anorectal motility and cardiac autonomic function. We also determined whether sleep and psychological status (e.g., anxiety and depression) would affect anorectal motility in RSW workers. Methods Sixteen RSW workers and 11 control individuals were involved in the study. All study participants underwent anorectal manometry and spectral analysis of heart rate variability. All participants completed three questionnaires: the Pittsburgh Sleep Quality Index (PSQI), the State-Trait Anxiety Inventory (STAI) questionnaire, and the Taiwanese Depression Questionnaire (TDQ). Results The RSW workers had a lower threshold volume for maximal urge (p = 0.006) and greater rectal compliance (p = 0.02), compared to the controls. The RSW workers had a greater PSQI score (p = 0.002) and TDQ score (p = 0.003), compared to the controls. The RSW workers had a significantly increased low-frequency power percentage (LF%), compared to the controls (p = 0.03). The RSW workers had a significant correlation between the resting anal sphincter pressure and high-frequency power percentage (HF%; r = –0.62, p = 0.01), and between the R-R interval and the threshold for maximal urge (r = 0.51, p = 0.04). The PSQI score was significantly correlated with the threshold volume for urge (r = 0.55, p = 0.03) and for compliance (r = 0.51, p = 0.04) in the RSW workers. Conclusion Rotating shift workers have anorectal dysmotility and cardiac sympathetic hyperactivity. Anorectal dysmotility in RSW workers has a close relationship with cardiac autonomic dysfunction, sleep disturbance, and depression, but not with anxiety.

      PubDate: 2016-09-15T09:14:32Z
      DOI: 10.1016/j.aidm.2015.03.002
       
  • Gastroprotective effect of bezafibrate, a peroxisome proliferator
           activated receptor α agonist and its mechanism in a rat model of
           aspirin-induced gastric ulcer

    • Authors: Lekha Saha; Alka Bhatia; Amitava Chakrabarti
      Pages: 101 - 110
      Abstract: Publication date: Available online 14 June 2016
      Source:Advances in Digestive Medicine
      Author(s): Lekha Saha, Alka Bhatia, Amitava Chakrabarti
      Background The aim of the present study was to demonstrate the antiulcer activity and mechanism of bezafibrate in a rat model of aspirin-induced gastric ulcer. Methods We used an aspirin-induced gastric ulcer model. Bezafibrate was administered orally in graded doses (10 mg/kg, 25 mg/kg, 50 mg/kg, 100 mg/kg, and 200 mg/kg) to detect the best effective antiulcer dose of bezafibrate. The parameters measured were: ulcer index, histopathological scoring of gastric ulcer, gastric juice analysis, gastric mucosal lipid peroxidation parameters, estimation of NO metabolite in blood, mRNA expression of inducible NO synthase iNOS and constitutive NO synthase (cNOS) in gastric mucosa, and gastric mucosal DNA fragmentation. Results The dose-dependent antiulcer activity of bezafibrate was shown by the ulcer index and histopathological score. Bezafibrate (100 mg/kg) significantly reduced total acidity, free acidity, and pepsin activity, and increased total hexoses and total proteins. Bezafibrate (100 mg/kg) also significantly reduced lipid peroxidation, inhibited iNOS expression, preserved cNOS expression, and inhibited DNA fragmentation. Conclusion Bezafibrate can decrease aspirin-induced gastric mucosal injury via reducing lipid peroxidation, inhibiting iNOS expression, preserving cNOS expression, and decreasing DNA fragmentation.

      PubDate: 2016-06-14T14:28:24Z
      DOI: 10.1016/j.aidm.2016.04.001
       
  • Probable autoimmune hepatitis and systemic sclerosis complicated by
           

    • Authors: Wen-Han Chang; Chih-Jen Chen; Chia-Yuan Liu; Ming-Jen Chen; Horng-Yuan Wang; Ching-Chung Lin
      Pages: 111 - 114
      Abstract: Publication date: September 2016
      Source:Advances in Digestive Medicine, Volume 3, Issue 3
      Author(s): Wen-Han Chang, Chih-Jen Chen, Chia-Yuan Liu, Ming-Jen Chen, Horng-Yuan Wang, Ching-Chung Lin
      Systemic sclerosis is a multisystem autoimmune rheumatic disorder characterized by fibrosis in the skin and internal organs but rarely with hepatic or brain involvement. Reversible posterior leukoencephalopathy syndrome is characterized by a unique pattern of brain vasogenic edema in the setting of neurotoxicity predominantly in the parietal and occipital regions. We report a case of systemic sclerosis associated with probable autoimmune hepatitis that progressed rapidly to reversible posterior leukoencephalopathy syndrome with loss of vision, seizures, and coagulopathy. Brain computed tomography showed faint low density in the bilateral occipital lobes and posterior parietal lobes with edematous change. Fortunately, the patient's clinical condition considerably improved 2 days following the initiation of 100mg intravenous hydrocortisone infusion.

      PubDate: 2016-09-15T09:14:32Z
      DOI: 10.1016/j.aidm.2015.05.001
       
  • Ectopic sebaceous gland in the esophagus—Case reports and review
           of the literature

    • Authors: Lin-Suei Jhang; Chien-Yuan Hung; Tze-Yu Shieh; Chen-Wang Chang; Horng-Yuan Wang; Shou-Chuan Shih; Ming-Jen Chen
      Pages: 118 - 122
      Abstract: Publication date: September 2016
      Source:Advances in Digestive Medicine, Volume 3, Issue 3
      Author(s): Lin-Suei Jhang, Chien-Yuan Hung, Tze-Yu Shieh, Chen-Wang Chang, Horng-Yuan Wang, Shou-Chuan Shih, Ming-Jen Chen
      Ectopic sebaceous glands (ESGs) are benign esophageal lesions that have a lower detection rate than malignant lesions because most patients are asymptomatic. However, this rate can be increased by the widespread use of endoscopes and an increasing awareness of the disease. Through esophagogastroduodenoscopy, ESGs often appear in the middle and lower esophagus in numbers ranging from 1 to more than 100 yellowish plaques measuring 1–2 mm in diameter. Histopathological examination of ESGs would reveal small lobular cluster glands in the lamina propria. Diagnosis is usually confirmed through an endoscopic biopsy. ESGs are best distinguished from other yellowish lesions such as xanthoma via endoscopy. These lesions tend to appear singly scattered, whereas xanthomas tend to be clustered. We present three cases of ESGs in the esophagus. Although their etiologies are still unclear, we present related theories in our review.

      PubDate: 2016-09-15T09:14:32Z
      DOI: 10.1016/j.aidm.2015.02.001
       
  • Intestinal ileus and pneumatosis intestinalis as the major manifestations
           of tuberculous peritonitis: A diagnostic challenge

    • Authors: Chang-Hua Chen; Kun-Ching Chou; Lien-Cheng Tsao
      Pages: 123 - 127
      Abstract: Publication date: Available online 24 March 2016
      Source:Advances in Digestive Medicine
      Author(s): Chang-Hua Chen, Kun-Ching Chou, Lien-Cheng Tsao
      Tuberculous peritonitis (TBP) is a continuing problem in populations with high prevalence of tuberculosis and is difficult to diagnose early. Here, we report a case of confirmed TBP that presented as intestinal ileus and pneumatosis intestinalis. The 79-year-old woman had a history of atrial fibrillation, chronic ischemic heart disease, and chronic renal failure (chronic kidney disease, stage V). She complained of abdominal fullness and pain for 1 week prior to hospitalization. A computed tomography (CT) scan revealed pneumatosis intestinalis. Laparoscopic surgery was performed, and multiple whitish nodules covering the peritoneum were discovered. Biopsy results were consistent with caseating granulomatous inflammation. A modified anti-tuberculosis regimen (isoniazid, 300 mg daily; rifampicin 600 mg daily; ethambutol 800 mg three times per week; and pyrazinamide 1200 mg three times per week) was initiated, stabilizing the condition of the patient. The total duration of anti-tuberculosis therapy was 12 months, with patient condition gradually improving to normal. The elderly, uremic patients recovered fully after the modified anti-tuberculosis regimen for 12 months. For clinical practice, we developed a decision-making algorithm for patients suspecting TBP.

      PubDate: 2016-03-24T10:49:22Z
      DOI: 10.1016/j.aidm.2015.11.001
       
  • Massive post-polypectomy hemorrhage: Successful tulip-bundle technique
           with endoloop for hemostasis

    • Authors: Hsu-Heng Yen; Chia-Wei Yang; Shun-Sheng Wu; Maw-Soan Soon
      Pages: 128 - 131
      Abstract: Publication date: Available online 5 March 2016
      Source:Advances in Digestive Medicine
      Author(s): Hsu-Heng Yen, Chia-Wei Yang, Shun-Sheng Wu, Maw-Soan Soon
      Colonoscopic polypectomy is a common procedure for removing colonic polyps to prevent subsequent development of colon cancer. Hemorrhage is the most common complication following polypectomy, with a reported rate of 0.3% to 6.0%. The risk increases to 12.5% when the size of the polyp stalk exceeds 1 cm. The most commonly used endoscopic preventive techniques, such as injection therapy, prophylactic use of endoclip, or endoloop, were found to decrease the rate of post-polypectomy hemorrhage, and repeated use of these techniques is useful for controlling bleeding. Here, we reported a case of a 65-year-old man with refractory post-polypectomy hemorrhage for a 2-cm adenomatous polyp. Application of an endoloop using the tulip-bundle technique achieved successful hemostasis. To our knowledge, this is the first report of this technique being used to treat refractory acute post-polypectomy hemorrhage.

      PubDate: 2016-03-09T23:34:31Z
      DOI: 10.1016/j.aidm.2016.01.002
       
  • A rare presentation of clinically intractable hypertension: Pancreatic
           paraganglioma

    • Authors: Chao-Ming Tseng; Jen-Wei Tsai; Chi-Ming Tai; Chi-Yang Chang; TaoQian Tang; Hsiu-Po Wang
      Pages: 132 - 134
      Abstract: Publication date: Available online 22 March 2016
      Source:Advances in Digestive Medicine
      Author(s): Chao-Ming Tseng, Jen-Wei Tsai, Chi-Ming Tai, Chi-Yang Chang, TaoQian Tang, Hsiu-Po Wang
      Paraganglioma is a rare extra-adrenal pheochromocytoma which originates from chromaffin cells within the ganglia of the sympathetic trunk and of the celiac, renal, suprarenal, and hypogastric plexuses. Pancreatic paragangliomas are rarer still. And even then, paragangliomas are mostly reported to be nonfunctional. We report a case of a 64-year-old woman with underlying disease of hypertension who presented with biliary colic. Contrast-enhanced computer tomography showed an enhancing mass in the uncinate process of the pancreas. Pylorus-sparing Whipple procedure was performed for complete tumor excision. Hypertensive crisis developed after Whipple, which improved after continuous intravenous nicardipine infusion. Pathology revealed a paraganglioma. A 24-h catecholamine urine test showed increased norepinephrine and vanillylmandelic acid level. Functional paraganglioma was diagnosed.

      PubDate: 2016-03-24T10:49:22Z
      DOI: 10.1016/j.aidm.2016.02.001
       
  • Cytomegalovirus enteritis in immunocompetent patients: Report of two cases
           diagnosed using single-balloon enteroscopy

    • Authors: Cheng-Lin Hsieh; Chia-Hung Tu; Min-Horn Tsai; Cher-Wei Liang; Hsiu-Po Wang; Ping-Huei Tseng
      Pages: 135 - 140
      Abstract: Publication date: Available online 3 June 2016
      Source:Advances in Digestive Medicine
      Author(s): Cheng-Lin Hsieh, Chia-Hung Tu, Min-Horn Tsai, Cher-Wei Liang, Hsiu-Po Wang, Ping-Huei Tseng
      Cytomegalovirus (CMV) infection of the gastrointestinal tract involves mostly the colon and rectum and mainly develops in immunocompromised patients. CMV infection in the small intestines has rarely been reported in immunocompetent patients. We report two cases of CMV enteritis that developed in immunocompetent patients and involved the ileum and jejunum, respectively. Both of them were diagnosed with single-balloon enteroscopy (SBE) and further confirmed with histopathology. The first case is a 71-year-old woman with a presentation of obscure gastrointestinal bleeding and severe anemia. Neither esophagogastroduodenoscopy nor colonoscopy identified any active bleeding. SBE and biopsy disclosed multiple scattered ulcers in the distal ileum and histopathology confirmed CMV ileitis. The hemorrhage subsided after conservative medical treatment. The second case is a 59-year-old woman with a presentation of progressive abdominal pain. SBE showed diffuse irregularly-shaped ulcers located from the upper to middle jejunum, and CMV jejunitis was confirmed with endoscopic biopsy and histopathological examination. Antiviral therapy was prescribed and her abdominal pain improved gradually. We discuss the clinical manifestations and management strategies of CMV infection that develops in the small intestines of immunocompetent patients. In addition, we highlight the endoscopic characteristics of CMV enteritis and the clinical utilities of SBE in the evaluation of patients with suspected CMV infection of the small intestines.

      PubDate: 2016-06-07T12:20:46Z
      DOI: 10.1016/j.aidm.2016.05.002
       
  • A young female with alternating diarrhea and constipation

    • Authors: Wei-Cheng Lee; Horng-Yuan Wang; Ming-Jen Chen; Wen-Hsiung Chang; Cheng-Hsin Chu; Tsang-En Wang; Shou-Chuan Shih; Kuang-Chun Hu
      Pages: 141 - 143
      Abstract: Publication date: September 2016
      Source:Advances in Digestive Medicine, Volume 3, Issue 3
      Author(s): Wei-Cheng Lee, Horng-Yuan Wang, Ming-Jen Chen, Wen-Hsiung Chang, Cheng-Hsin Chu, Tsang-En Wang, Shou-Chuan Shih, Kuang-Chun Hu


      PubDate: 2016-09-15T09:14:32Z
      DOI: 10.1016/j.aidm.2015.04.004
       
  • A modified bowel preparation protocol improves the quality of bowel
           cleansing for colonoscopy

    • Authors: Wei-Fan Hsu; Cheng-Chao Liang; Cheng-Kuan Lin; Tzong-Hsi Lee; Chen-Shuan Chung
      Pages: 144 - 147
      Abstract: Publication date: Available online 23 March 2016
      Source:Advances in Digestive Medicine
      Author(s): Wei-Fan Hsu, Cheng-Chao Liang, Cheng-Kuan Lin, Tzong-Hsi Lee, Chen-Shuan Chung
      Adequate colonic cleansing is essential for a high quality colonoscopy. Few studies have investigated the association between patient education and quality of bowel preparation. The control group comprised 165 participants who underwent colonoscopy after a standard bowel preparation protocol during the period September–October 2013 and the study group comprised 251 individuals who underwent colonoscopy after a modified bowel preparation protocol during the period January–February 2014. The modified bowel preparation protocol included an instructional video and leaflet, a dietician-designed 2-day low fiber diet, a follow-up phone message, and information to confirm stool characteristics. The Aronchick Bowel Preparation Scale was used to define the quality of bowel preparation. The endoscopists who performed the procedures were blinded to the preparation protocols. The percentage of participants with excellent bowel preparation quality was significantly higher in the study group than in the control group (35.9% vs. 21.8%, p = 0.002). Also, the percentage of participants with poorly prepared bowels was significantly higher in the control group than in the study group (3% vs. 0.8%, p = 0.042). Moreover, the adenoma detection rate was significantly higher in the study group (35.1% vs. 24.8%, p = 0.028). The results show that the quality of bowel cleansing can be improved by providing patients with a modified bowel preparation protocol.

      PubDate: 2016-03-24T10:49:22Z
      DOI: 10.1016/j.aidm.2015.12.001
       
  • Insulin resistance and anti-hepatitis C virus therapy

    • Authors: Chia-Yen Dai
      Pages: 37 - 39
      Abstract: Publication date: Available online 1 May 2016
      Source:Advances in Digestive Medicine
      Author(s): Chia-Yen Dai


      PubDate: 2016-05-03T08:17:50Z
      DOI: 10.1016/j.aidm.2016.03.004
       
  • Transnasal endoscopic gastrostomy for patients whose condition limits
           standard oral endoscopic intubation

    • Authors: Chu-Kuang Chou; Yi-Chia Lee
      Pages: 40 - 42
      Abstract: Publication date: Available online 23 April 2016
      Source:Advances in Digestive Medicine
      Author(s): Chu-Kuang Chou, Yi-Chia Lee


      PubDate: 2016-04-28T01:40:57Z
      DOI: 10.1016/j.aidm.2016.03.003
       
  • Change in insulin resistance according to virological response during
           antiviral treatment for hepatitis C virus infection

    • Authors: Cheng-Hao Tseng; Yao-Chun Hsu; Chi-Yang Chang; Chih-Wen Lin; Jaw-Town Lin; Lein-Ray Mo
      Pages: 43 - 48
      Abstract: Publication date: June 2016
      Source:Advances in Digestive Medicine, Volume 3, Issue 2
      Author(s): Cheng-Hao Tseng, Yao-Chun Hsu, Chi-Yang Chang, Chih-Wen Lin, Jaw-Town Lin, Lein-Ray Mo
      Background Hepatitis C virus (HCV) infection can lead to increased insulin resistance, but the dynamics of insulin resistance in HCV-infected patients receiving pegylated interferon plus ribavirin remain elusive. Methods This prospective study enrolled HCV-infected patients who received pegylated interferon plus ribavirin. Patients were classified according to the attainment of sustained virological response (SVR). Insulin resistance was measured using homeostatic model assessment-insulin resistance (HOMA-IR). The change in HOMA-IR at baseline, the end of treatment, and 24 weeks after the end of treatment was compared in patients who achieved SVR and those who did not. Results A total of 65 patients participated in this study, of which 46 (71%) achieved SVR. Overall, The HOMA-IR changed significantly during antiviral therapy, with the median values [interquartile range (IQR)] of 3.7 (1.6–10.0) prior to the treatment, 1.5 (0.8–2.9) at the end, and 1.6 (0.9–3.1) at 24 weeks after completion of therapy. However, only patients who achieved SVR had significant off-therapy reduction of HOMA-IR, with median values of 1.3 (IQR, 0.7–2.6) at 24 weeks off therapy and 3.6 (IQR, 1.5–9.9) at baseline (p < 0.0001). In those without SVR, the HOMA-IR measured 24 weeks after treatment completion (median, 2.2; IQR, 1.9–4.7) did not differ from baseline values (median, 3.9; IQR, 2.2–10.0; p = 0.5). Conclusion Dual therapy with pegylated interferon plus ribavirin ameliorated IR in HCV-infected patients, but the off-therapy improvement of IR was limited to those who attained SVR.

      PubDate: 2016-06-02T09:14:10Z
      DOI: 10.1016/j.aidm.2014.12.003
       
  • Transnasal versus conventional peroral insertion of percutaneous
           endoscopic gastrostomy using pull method

    • Authors: Lian Feng Lin
      Pages: 56 - 60
      Abstract: Publication date: June 2016
      Source:Advances in Digestive Medicine, Volume 3, Issue 2
      Author(s): Lian Feng Lin
      Background Several cases of successful percutaneous endoscopic gastrostomy (PEG) through the transnasal route have been reported, and Pseudomonas aeruginosa infection in transnasal PEG was described earlier. This study was conducted to investigate the difference between transnasal PEG and conventional PEG. Methods A retrospective case–control study was conducted to compare pull-type transnasal (T-PEG) and peroral (O-PEG) placement of a 20 Fr PEG tube in a community hospital. Thirty-eight T-PEG and 38 O-PEG were analyzed in 76 chronic dysphagic patients from homes or nursing homes. The operating time, occurrence of choking during PEG, stomal site infection, bacterial pathogens, and post-PEG complication were recorded and analyzed. Results The mean age was 76.3 ± 10.3 years for T-PEG versus 79.3 ± 6.9 years for O-PEG; 67% were male versus 48% female; operating time was 14.6 ± 4.0 minutes for T-PEG versus 11 ± 3 minutes for O-PEG (p = 0.0028), and choking occurred in three patients in the T-PEG group versus five in the O-PEG group. There were 10 stomal site infections (9 with P. aeruginosa) in the T-PEG group and 14 (8 with P. aeruginosa) in the O-PEG group (p < 0.001). One systemic infection of the urinary tract, one buried bumper, and one stomal soiling were observed in the T-PEG and O-PEG groups. No PEG-related mortality occurred within 3 months after all PEG procedures. Conclusion Transnasal insertion of PEG using a pull method is a feasible and safe alternative when conventional pull-method PEG is not possible. However, P. aeruginosa infection is common when using T-PEG; therefore, more studies focusing on prophylaxis of T-PEG-associated P. aeruginosa infection are required.

      PubDate: 2016-06-02T09:14:10Z
      DOI: 10.1016/j.aidm.2014.12.002
       
  • Gallbladder sarcomatoid carcinoma: A case report and review of current
           literature

    • Authors: Ming-Wun Wong; Ming-Jen Chen; Chih-Jen Chen; Chien-Yuan Hung; Horng-Yuan Wang; Ching-Wei Chang
      Pages: 61 - 64
      Abstract: Publication date: June 2016
      Source:Advances in Digestive Medicine, Volume 3, Issue 2
      Author(s): Ming-Wun Wong, Ming-Jen Chen, Chih-Jen Chen, Chien-Yuan Hung, Horng-Yuan Wang, Ching-Wei Chang
      Gallbladder sarcomatoid carcinoma is a rare neoplasm characterized by the simultaneous presence of malignant epithelial and mesenchymal components. There is little information about the clinical behavior and optimal treatment for these tumors. The current study examines the case of a 52-year-old female patient who presented with postprandial epigastric pain that had persisted for 1 year. A diagnosis of gallbladder sarcomatoid carcinoma was confirmed by pathology after radical resection. Peritoneal metastasis occurred 3 months later, and the patient died 6 months after diagnosis. This study found that the prognosis of gallbladder sarcomatoid carcinoma is poor even after curative resection and there is as yet no known effective adjuvant therapy.

      PubDate: 2016-06-02T09:14:10Z
      DOI: 10.1016/j.aidm.2014.10.003
       
  • Amebic and cytomegalovirus colitis mimic ulcerative colitis

    • Authors: Meng-Tzu Weng; Shu-Chen Wei; Yew-Loong Leong; Chien-Chih Tung; Chia-Tung Shun; Jau-Min Wong
      Pages: 65 - 68
      Abstract: Publication date: June 2016
      Source:Advances in Digestive Medicine, Volume 3, Issue 2
      Author(s): Meng-Tzu Weng, Shu-Chen Wei, Yew-Loong Leong, Chien-Chih Tung, Chia-Tung Shun, Jau-Min Wong
      Here we present a 50-year-old man who suffered from progressively bloody diarrhea for 2 months. A colonoscopy revealed pancolonic mucosal inflammation, ulceration, and spontaneous bleeding. Ulcerative colitis was initially diagnosed and sulfasalazine was prescribed. Hypoalbuminemia and renal function deterioration developed 1 year later. Steroids were prescribed for suspected nephrotic syndrome. His bloody diarrhea and abdominal symptoms worsened after steroid use. Progressive sepsis and acute renal function deterioration also developed. Positive human immunodeficiency virus (HIV) antibody was found during routine hemodialysis screening. An episode of colon perforation occurred and surgery was performed. The resected colon showed amoeba, cytomegalovirus, and fungal infection. The patient died of sepsis. In this report, we discuss how to diagnose ulcerative colitis. It is important to exclude infection before using an immunosuppressive agent.

      PubDate: 2016-06-02T09:14:10Z
      DOI: 10.1016/j.aidm.2014.10.002
       
  • Hepatic cystic metastatic tumors from a locally controlled nasopharyngeal
           carcinoma

    • Authors: Kai-Wen Chen; Hsuan-Wei Chen; Tzu-Ming Ou; Wen-Chiuan Tsai; Tsai-Yuan Hsieh
      Pages: 69 - 72
      Abstract: Publication date: June 2016
      Source:Advances in Digestive Medicine, Volume 3, Issue 2
      Author(s): Kai-Wen Chen, Hsuan-Wei Chen, Tzu-Ming Ou, Wen-Chiuan Tsai, Tsai-Yuan Hsieh
      Liver cystic neoplasms are uncommon and vary from benign to overtly malignant. Liver cystic metastases are rare and mostly come from colon, pancreas, ovary, kidney, neuroendocrine, and prostate cancer. Nasopharyngeal carcinoma (NPC) with liver cystic metastasis has only been reported once. Here, we report a 52-year-old man with liver cystic metastasis from locally cured NPC. The patient received concurrent chemoradiotherapy for NPC 4 years ago and presented with a 6-month history of upper abdominal fullness and pain. No evidence of local recurrence of NPC was found at his regular follow-up examinations after concurrent chemoradiotherapy. Abdominal magnetic resonance imaging showed a large, well-defined, lobulated cystic lesion with poor contrast enhancement occupying both lobes of the liver. Hepatic cystic metastasis was suspected. Ultrasound-guided liver tumor biopsy was performed. Histological examinations disclosed a pattern of poorly differentiated squamous cell carcinoma with focal sarcomatoid differentiation based on the P40 immunohistochemical stain. In situ hybridization for Epstein–Barr virus early RNAs confirmed the diagnosis of metastatic NPC. It is difficult to make a diagnosis in liver cystic neoplasms, especially from a rarely reported origin. In our case, we used clinical history and Epstein–Barr virus early RNAs as a specific marker to make an accurate diagnosis.

      PubDate: 2016-06-02T09:14:10Z
      DOI: 10.1016/j.aidm.2014.09.001
       
  • An appendix adenocarcinoma mimicking appendicitis

    • Authors: Ho-Li Wang; Chen-Kun Lin; Chun-Che Lin
      Pages: 73 - 75
      Abstract: Publication date: Available online 28 March 2016
      Source:Advances in Digestive Medicine
      Author(s): Ho-Li Wang, Chen-Kun Lin, Chun-Che Lin
      Cancer of the appendix is very rare and is typically found incidentally in approximately 1% of patients who received appendectomies. Most of appendiceal tumors are carcinoid, adenoma, and lymphoma. Adenocarcinoma of the appendix accounts for only 10% of all primary appendiceal cancers and the treatment remains controversial. In this article, we report a 67-year-old man who presented with symptoms of appendicitis that was diagnosed as adenocarcinoma of the appendix Stage II. The patient was treated with right hemicolectomy. To date he remains asymptomatic.

      PubDate: 2016-03-30T11:25:33Z
      DOI: 10.1016/j.aidm.2015.11.002
       
  • Simple predictor for anemia in chronic hepatitis C patients receiving
           peginterferon plus ribavirin

    • Authors: Chun-Jen Liu
      Pages: 1 - 2
      Abstract: Publication date: Available online 3 March 2016
      Source:Advances in Digestive Medicine
      Author(s): Chun-Jen Liu


      PubDate: 2016-03-03T21:35:28Z
      DOI: 10.1016/j.aidm.2016.01.001
       
  • Percutaneous radiofrequency ablation for hepatocellular carcinoma:
           Shortened duration does not comprise its efficacy

    • Authors: Chien-Hung Chen
      Abstract: Publication date: Available online 25 November 2016
      Source:Advances in Digestive Medicine
      Author(s): Chien-Hung Chen


      PubDate: 2016-11-29T11:23:19Z
      DOI: 10.1016/j.aidm.2016.10.001
       
  • Endoscopic-ultrasound-guided cystogastrostomy for walled-off necrosis of
           the pancreas

    • Authors: Chun-Han Cheng; Chia-Hsien Wu; Ming-Jong Bair
      Abstract: Publication date: Available online 10 July 2016
      Source:Advances in Digestive Medicine
      Author(s): Chun-Han Cheng, Chia-Hsien Wu, Ming-Jong Bair


      PubDate: 2016-07-14T14:04:38Z
      DOI: 10.1016/j.aidm.2016.05.003
       
  • Unexpected and unintentional fish bone ingestion causing acute abdomen and
           uncommon small intestinal perforation

    • Authors: Tsung-Han Yang; Chiao-Yi Lu
      Abstract: Publication date: Available online 2 June 2016
      Source:Advances in Digestive Medicine
      Author(s): Tsung-Han Yang, Chiao-Yi Lu
      Perforation of the mesenteric small bowel is an uncommon cause of acute abdomen in the emergency department. Early diagnosis is difficult owing to unspecific clinical presentations. The most common causes of perforation are tumor, trauma, Crohn's disease, ischemia, and foreign body ingestion. Currently, computed tomography (CT) is often the initial modality used to assess patients with acute abdomen, and the excellent anatomic details it provides, including segmental bowel wall thickening, mesenteric air bubbles, and fatty infiltration, may help the clinician to diagnose earlier and with greater ease. Here, we present a case of acute abdomen diagnosed as small bowel perforation due to unintentional fish bone ingestion using multidetector CT. The multiplanar reconstruction images from multidetector CT helped locate the perforation site before surgical intervention.

      PubDate: 2016-06-07T12:20:46Z
      DOI: 10.1016/j.aidm.2016.04.003
       
  • Hepatitis C virus treatment update — A new era of all-oral HCV
           treatment

    • Authors: Kazuaki Chayama; Michio Imamura; C. Nelson Hayes
      Abstract: Publication date: Available online 25 May 2016
      Source:Advances in Digestive Medicine
      Author(s): Kazuaki Chayama, Michio Imamura, C. Nelson Hayes
      There are estimated to be more than a hundred million hepatitis C virus (HCV) carriers worldwide. About 30% of carriers develop serious liver diseases, such as liver cirrhosis and hepatocellular carcinoma. HCV Genotype 1 is the most common genotype worldwide and the most difficult to treat with interferon-based therapy. Therapy for patients with chronic HCV infection is complicated by poor tolerability and inadequate rates of sustained virological response (SVR). Although the addition of a protease inhibitor in combination with peg-interferon alpha plus ribavirin improved SVR rates and shortened the treatment period, many patients could not tolerate this therapy because of advanced age and clinical conditions such as anemia and low platelet count. Interferon-free therapies that combine two or more direct-acting antiviral (DAA) agents can improve both efficacy and tolerability. Phase III trials of daclatasvir plus asunaprevir, ombitasvir plus parataprevir/r, and sofosbuvir plus ledipasvir all showed high overall SVR rates with few adverse events. However, development of antiviral resistance is a concern with DAA therapies, and it is important to avoid treating patients with existing NS5A Y93H mutations with daclatasvir plus asunaprevir or ombitasvir plus parataprevir/r therapy to prevent viral breakthrough. Fortunately, sofosbuvir plus ledipasvir therapy seems to be less affected by NS5A Y93H variants. An important goal of HCV therapy is to expand treatment to all patients. The current study aims to show the efficacy and safety of these therapies both in clinical trial and real world settings based on our own clinical experiences.

      PubDate: 2016-05-26T20:45:56Z
      DOI: 10.1016/j.aidm.2016.03.002
       
  • Utility of balloon expulsion test in patients with constipation:
           Preliminary results in a single center

    • Authors: Ching-Sheng Hsu; Tso-Tsai Liu; Chih-Hsun Yi; Wei-Yi Lei; Jui-Sheng Hung; Chien-Lin Chen
      Abstract: Publication date: Available online 19 May 2016
      Source:Advances in Digestive Medicine
      Author(s): Ching-Sheng Hsu, Tso-Tsai Liu, Chih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Chien-Lin Chen
      Background Pelvic floor dyssynergia can be a cause of idiopathic constipation. Although pelvic floor dyssynergia can be diagnosed by rectal balloon expulsion (BE) and anorectal manometry, the utility of BE in the evaluation of constipation in clinical practice remains to be determined. To this end, we examined the role of BE among different body positions in Taiwanese people with constipation. Methods Fourteen Taiwanese adults (age range, 19–61 years), including six healthy volunteers (4 male, 2 female) and eight patients with chronic constipation (1 male, 7 female) underwent solid-state anorectal manometry and BE. The demographic data of all individuals were recorded at enrollment. Results Compared to healthy volunteers, patients with chronic constipation had a numerically lower threshold for mean resting pressure (p = 0.052), squeeze pressure, maximal squeeze pressure, and lower threshold volumes for urge, but higher threshold pressures for compliance. Successful BE seemed to be associated with lower mean resting pressure (p = 0.061), lower mean threshold volumes for urge, and higher mean maximal squeeze pressure for compliance. Although patients with chronic constipation had a numerically lower successful rate of rectal BE than healthy controls, the differences did not reach statistical significance. Conclusion In Taiwanese individuals, results of BE seems consistent with anorectal manometry parameters, and patients with chronic constipation have a trend of lower successful rate of rectal BE than healthy controls. However, future work to confirm the use of BE in differentiating subtypes of chronic constipation is needed.

      PubDate: 2016-05-20T20:01:00Z
      DOI: 10.1016/j.aidm.2016.04.002
       
  • Refractory gastric variceal bleeding secondary to splenic vein occlusion
           associated with abdominal lymphadenopathy

    • Authors: Yu-Chun Lin; Yen-Bo Chen Po-Hao Liao Wen-Chi Chao Jiunn-Chang Lin
      Abstract: Publication date: Available online 26 April 2016
      Source:Advances in Digestive Medicine
      Author(s): Yu-Chun Lin, Yen-Bo Chen, Po-Hao Liao, Wen-Chi Chao, Jiunn-Chang Lin, Yu-Chung Hong, Shen-Yung Wang
      Splenic vein occlusion caused by abdominal lymphadenopathy is rare. We herein present the case of a 80-year-old man with refractory isolated gastric variceal bleeding in the absence of pancreatic or liver disease. Left-sided portal hypertension was confirmed by angiography, and para-aortic lymphadenopathy compressing the splenic vein was identified by serial abdominal computed tomography. Endoscopic sclerosing therapy failed to treat the recurring gastric variceal hemorrhage. Therefore, splenectomy was suggested and the patient was successfully treated. The patient had been variceal bleeding free for 12 months since the surgery. In patients with isolated gastric varices but without advanced liver disease, a variety of diagnostic techniques should be attempted to elucidate the nature of portal hypertension, and left-sided portal hypertension should be suspected. For those cases in which endoscopic treatment failed to treat refractory gastric variceal bleeding, splenectomy can be an effective option.

      PubDate: 2016-04-28T01:40:57Z
       
  • Bile aspiration enhances the diagnostic accuracy of Clonorchis sinensis: A
           case report

    • Authors: Te-Fu Lin; Hoi-Hung Chan; Ping-I Hsu; Tzung-Jiun Tsai; E-Ming Wang; Kwok-Hung Lai; Jin-Shiung Cheng; Huay-Min Wang
      Abstract: Publication date: Available online 28 March 2016
      Source:Advances in Digestive Medicine
      Author(s): Te-Fu Lin, Hoi-Hung Chan, Ping-I Hsu, Tzung-Jiun Tsai, E-Ming Wang, Kwok-Hung Lai, Jin-Shiung Cheng, Huay-Min Wang
      Clonorchis sinensis is endemic to Southeast Asia, Japan, China, and Taiwan. Those infected often have a history of consumption of raw fresh fish. Its manifestations can be asymptomatic of cholangitis, biliary stones, or cholangiocarcinoma. A 69-year-old male living in Chishan, Taiwan visited our hospital with obstructive jaundice. Noninvasive analyses, such as stool examination, abdominal ultrasound, and an abdominal computed tomography scan did not reveal clues of clonorchiasis. As the obstructive jaundice was unexplained, endoscopic retrograde cholangiopancreatography (ERCP) was then performed and a hepatic fluke was seen via aspiration of bile. Subsequently, the ova of C. sinensis were detected via microscopic examination of bile samples. Bile aspiration is not routine during an ERCP procedure; however, we suggest the bile aspiration can be diagnostically accurate for clonorchiasis, especially for patients with a suspicious infection.

      PubDate: 2016-03-30T11:25:33Z
      DOI: 10.1016/j.aidm.2016.02.002
       
  • Percutaneous radiofrequency ablation for hepatocellular carcinoma: Early
           termination versus standard termination of ablation procedure

    • Authors: Ya-Ting Cheng; Arlinking Ong; Chen-Chun Lin; Chun-Jung Lin; Wei-Ting Chen; Shi-Ming Lin
      Abstract: Publication date: Available online 31 December 2015
      Source:Advances in Digestive Medicine
      Author(s): Ya-Ting Cheng, Arlinking Ong, Chen-Chun Lin, Chun-Jung Lin, Wei-Ting Chen, Shi-Ming Lin
      Objective To compare the effectiveness of early termination (ET) and standard termination (ST) of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) using internally cooled electrodes. Methods Eighty-three treatment naïve patients with HCC with 101 index tumor underwent RFA. ET was defined as termination of ablation if after 6 minutes the power emission was < 10 seconds for three times per minute under maximal power. Standard termination was defined as termination of ablation according to manufactures’ algorithms of 12 minutes’ procedure. Primary end point was complete ablation of index tumor after 4 weeks of RFA. Results Nineteen patients (22.9%) underwent ET and 64 patients (77.1%) underwent ST. The mean size of the index tumor was 2.2 + 0.9 cm. Patient had complete ablation of the index tumor at 92.0% for the ET and 88.2% for the ST (p = 0.593). Eight of 25 (32.0%) for the ET and 18 of 73 (24.7%) for the ST group had local tumor progression on last follow-up (p = 0.473). After a median follow-up of 23 weeks (range, 9–33 weeks), the 24 weeks cumulative probability of local tumor progression was not different between ET (46.2%) and ST (25.6%; p = 0.387). Complete ablation at 4 weeks was the only independent factor associated with local tumor progression (adjusted hazard ratio 0.04, 95% confidence interval 0.01–0.16, p < 0.001). Conclusion Using ET in RFA is as effective as the ST in achieving complete ablation and local tumor progression.

      PubDate: 2016-01-04T05:47:54Z
      DOI: 10.1016/j.aidm.2015.07.001
       
 
 
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