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Publisher: Elsevier   (Total: 3163 journals)

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Showing 1 - 200 of 3163 Journals sorted alphabetically
A Practical Logic of Cognitive Systems     Full-text available via subscription   (Followers: 9)
AASRI Procedia     Open Access   (Followers: 14)
Academic Pediatrics     Hybrid Journal   (Followers: 30, SJR: 1.655, h-index: 2)
Academic Radiology     Hybrid Journal   (Followers: 22, SJR: 1.015, h-index: 2)
Accident Analysis & Prevention     Partially Free   (Followers: 88, SJR: 1.462, h-index: 3)
Accounting Forum     Hybrid Journal   (Followers: 25, SJR: 0.932, h-index: 2)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 35, SJR: 1.771, h-index: 3)
Achievements in the Life Sciences     Open Access   (Followers: 5)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 7)
Acta Astronautica     Hybrid Journal   (Followers: 394, SJR: 0.758, h-index: 2)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 2)
Acta Biomaterialia     Hybrid Journal   (Followers: 27, SJR: 1.967, h-index: 7)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 2)
Acta de Investigación Psicológica     Open Access   (Followers: 3)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.18, h-index: 1)
Acta Haematologica Polonica     Free   (Followers: 1, SJR: 0.128, h-index: 0)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.661, h-index: 2)
Acta Materialia     Hybrid Journal   (Followers: 244, SJR: 3.263, h-index: 6)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.504, h-index: 1)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.542, h-index: 1)
Acta Oecologica     Hybrid Journal   (Followers: 10, SJR: 0.834, h-index: 2)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription  
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 2, SJR: 0.307, h-index: 0)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1, SJR: 1.793, h-index: 6)
Acta Poética     Open Access   (Followers: 4, SJR: 0.101, h-index: 0)
Acta Psychologica     Hybrid Journal   (Followers: 27, SJR: 1.331, h-index: 2)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.052, h-index: 2)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3, SJR: 0.374, h-index: 1)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.344, h-index: 1)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 1)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 6, SJR: 0.19, h-index: 0)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 3)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 6)
Acute Pain     Full-text available via subscription   (Followers: 15, SJR: 2.671, h-index: 5)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.53, h-index: 4)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.29, h-index: 3)
Addictive Behaviors Reports     Open Access   (Followers: 8, SJR: 0.755, h-index: 2)
Additive Manufacturing     Hybrid Journal   (Followers: 9, SJR: 2.611, h-index: 8)
Additives for Polymers     Full-text available via subscription   (Followers: 22)
Advanced Cement Based Materials     Full-text available via subscription   (Followers: 3, SJR: 0.732, h-index: 3)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 135, SJR: 4.09, h-index: 13)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.167, h-index: 4)
Advanced Powder Technology     Hybrid Journal   (Followers: 16, SJR: 0.694, h-index: 3)
Advances in Accounting     Hybrid Journal   (Followers: 8, SJR: 0.277, h-index: 1)
Advances in Agronomy     Full-text available via subscription   (Followers: 12, SJR: 2.384, h-index: 5)
Advances in Anesthesia     Full-text available via subscription   (Followers: 28, SJR: 0.126, h-index: 0)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 2)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 10, SJR: 0.992, h-index: 1)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 10, SJR: 1.551, h-index: 4)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 22, SJR: 2.089, h-index: 5)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 14, SJR: 0.572, h-index: 2)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.61, h-index: 7)
Advances in Botanical Research     Full-text available via subscription   (Followers: 2, SJR: 0.686, h-index: 2)
Advances in Cancer Research     Full-text available via subscription   (Followers: 29, SJR: 3.043, h-index: 6)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 7, SJR: 1.453, h-index: 2)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 1.992, h-index: 5)
Advances in Cell Aging and Gerontology     Full-text available via subscription   (Followers: 3)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 27, SJR: 0.156, h-index: 1)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.713, h-index: 1)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 10, SJR: 1.316, h-index: 2)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28, SJR: 1.562, h-index: 3)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 19, SJR: 1.977, h-index: 8)
Advances in Computers     Full-text available via subscription   (Followers: 14, SJR: 0.205, h-index: 1)
Advances in Dermatology     Full-text available via subscription   (Followers: 15)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 11)
Advances in Digestive Medicine     Open Access   (Followers: 8)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 23)
Advances in Ecological Research     Full-text available via subscription   (Followers: 42, SJR: 2.524, h-index: 4)
Advances in Engineering Software     Hybrid Journal   (Followers: 27, SJR: 1.159, h-index: 4)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 7)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 43, SJR: 5.39, h-index: 8)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 1)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 9)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 53, SJR: 0.591, h-index: 2)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 17)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 1.354, h-index: 4)
Advances in Genome Biology     Full-text available via subscription   (Followers: 8, SJR: 12.74, h-index: 13)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 1.193, h-index: 3)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 21, SJR: 0.368, h-index: 1)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 11, SJR: 0.749, h-index: 3)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 22)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.193, h-index: 0)
Advances in Immunology     Full-text available via subscription   (Followers: 37, SJR: 4.433, h-index: 6)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 1.163, h-index: 2)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 2, SJR: 1.938, h-index: 3)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6, SJR: 0.176, h-index: 0)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 3)
Advances in Life Course Research     Hybrid Journal   (Followers: 8, SJR: 0.682, h-index: 2)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Marine Biology     Full-text available via subscription   (Followers: 14, SJR: 0.88, h-index: 2)
Advances in Mathematics     Full-text available via subscription   (Followers: 11, SJR: 3.027, h-index: 2)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6, SJR: 0.694, h-index: 2)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.158, h-index: 3)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 21)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 8)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.182, h-index: 0)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 3)
Advances in Oncobiology     Full-text available via subscription   (Followers: 1)
Advances in Organ Biology     Full-text available via subscription   (Followers: 1)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 16, SJR: 1.875, h-index: 4)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 6, SJR: 0.174, h-index: 0)
Advances in Parasitology     Full-text available via subscription   (Followers: 5, SJR: 1.579, h-index: 4)
Advances in Pediatrics     Full-text available via subscription   (Followers: 24, SJR: 0.461, h-index: 1)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 10)
Advances in Pharmacology     Full-text available via subscription   (Followers: 16, SJR: 1.536, h-index: 3)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.574, h-index: 1)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.109, h-index: 1)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 19, SJR: 0.791, h-index: 2)
Advances in Psychology     Full-text available via subscription   (Followers: 59)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 6, SJR: 0.371, h-index: 1)
Advances in Radiation Oncology     Open Access   (SJR: 0.263, h-index: 1)
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.101, h-index: 0)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 5)
Advances in Space Research     Full-text available via subscription   (Followers: 386, SJR: 0.569, h-index: 2)
Advances in Structural Biology     Full-text available via subscription   (Followers: 5)
Advances in Surgery     Full-text available via subscription   (Followers: 10, SJR: 0.555, h-index: 2)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 29, SJR: 2.208, h-index: 4)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 17)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 2.262, h-index: 5)
Advances in Water Resources     Hybrid Journal   (Followers: 46, SJR: 1.551, h-index: 3)
Aeolian Research     Hybrid Journal   (Followers: 6, SJR: 1.117, h-index: 3)
Aerospace Science and Technology     Hybrid Journal   (Followers: 335, SJR: 0.796, h-index: 3)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.42, h-index: 2)
African J. of Emergency Medicine     Open Access   (Followers: 6, SJR: 0.296, h-index: 0)
Ageing Research Reviews     Hybrid Journal   (Followers: 10, SJR: 3.671, h-index: 9)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 438, SJR: 1.238, h-index: 3)
Agri Gene     Hybrid Journal   (SJR: 0.13, h-index: 0)
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 1.818, h-index: 5)
Agricultural Systems     Hybrid Journal   (Followers: 31, SJR: 1.156, h-index: 4)
Agricultural Water Management     Hybrid Journal   (Followers: 43, SJR: 1.272, h-index: 3)
Agriculture and Agricultural Science Procedia     Open Access   (Followers: 1)
Agriculture and Natural Resources     Open Access   (Followers: 2)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 56, SJR: 1.747, h-index: 4)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.589, h-index: 3)
Air Medical J.     Hybrid Journal   (Followers: 6, SJR: 0.26, h-index: 0)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.19, h-index: 0)
Alcohol     Hybrid Journal   (Followers: 11, SJR: 1.153, h-index: 3)
Alcoholism and Drug Addiction     Open Access   (Followers: 9)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.604, h-index: 3)
Alexandria J. of Medicine     Open Access   (Followers: 1, SJR: 0.191, h-index: 1)
Algal Research     Partially Free   (Followers: 10, SJR: 1.142, h-index: 4)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.504, h-index: 1)
Allergology Intl.     Open Access   (Followers: 5, SJR: 1.148, h-index: 2)
Alpha Omegan     Full-text available via subscription   (SJR: 3.521, h-index: 6)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 9, SJR: 0.201, h-index: 1)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 50, SJR: 4.66, h-index: 10)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 4, SJR: 1.796, h-index: 4)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 4, SJR: 1.108, h-index: 3)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 6)
American Heart J.     Hybrid Journal   (Followers: 50, SJR: 3.267, h-index: 4)
American J. of Cardiology     Hybrid Journal   (Followers: 51, SJR: 1.93, h-index: 3)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 44, SJR: 0.604, h-index: 1)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 10)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.524, h-index: 3)
American J. of Human Genetics     Hybrid Journal   (Followers: 32, SJR: 7.45, h-index: 8)
American J. of Infection Control     Hybrid Journal   (Followers: 26, SJR: 1.062, h-index: 2)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 34, SJR: 2.973, h-index: 4)
American J. of Medicine     Hybrid Journal   (Followers: 43)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3, SJR: 1.967, h-index: 2)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 201, SJR: 2.7, h-index: 4)
American J. of Ophthalmology     Hybrid Journal   (Followers: 62, SJR: 3.184, h-index: 4)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 6, SJR: 0.265, h-index: 0)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.289, h-index: 1)
American J. of Otolaryngology     Hybrid Journal   (Followers: 25, SJR: 0.59, h-index: 1)
American J. of Pathology     Hybrid Journal   (Followers: 27, SJR: 2.139, h-index: 4)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 27, SJR: 2.164, h-index: 4)
American J. of Surgery     Hybrid Journal   (Followers: 37, SJR: 1.141, h-index: 2)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.767, h-index: 1)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 6)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.144, h-index: 3)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 63, SJR: 0.138, h-index: 0)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 15, SJR: 0.411, h-index: 1)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 3, SJR: 0.277, h-index: 0)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription  
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 5, SJR: 4.849, h-index: 10)
Analytica Chimica Acta     Hybrid Journal   (Followers: 39, SJR: 1.512, h-index: 5)
Analytical Biochemistry     Hybrid Journal   (Followers: 173, SJR: 0.633, h-index: 2)
Analytical Chemistry Research     Open Access   (Followers: 10, SJR: 0.411, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 11)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 2)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 23, SJR: 0.683, h-index: 2)
Angiología     Full-text available via subscription   (SJR: 0.121, h-index: 0)
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1, SJR: 0.111, h-index: 0)

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Journal Cover
Advances in Biological Regulation
Journal Prestige (SJR): 2.61
Citation Impact (citeScore): 7
Number of Followers: 4  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 2212-4926
Published by Elsevier Homepage  [3163 journals]
  • Sphingosine 1-phosphate and cancer
    • Authors: Nigel J. Pyne; Ashref El Buri; David R. Adams; Susan Pyne
      Pages: 97 - 106
      Abstract: Publication date: May 2018
      Source:Advances in Biological Regulation, Volume 68
      Author(s): Nigel J. Pyne, Ashref El Buri, David R. Adams, Susan Pyne
      The bioactive lipid, sphingosine 1-phosphate (S1P) is produced by phosphorylation of sphingosine and this is catalysed by two sphingosine kinase isoforms (SK1 and SK2). Here we discuss structural functional aspects of SK1 (which is a dimeric quaternary enzyme) that relate to coordinated coupling of membrane association with phosphorylation of Ser225 in the ‘so-called’ R-loop, catalytic activity and protein-protein interactions (e.g. TRAF2, PP2A and Gq). S1P formed by SK1 at the plasma-membrane is released from cells via S1P transporters to act on S1P receptors to promote tumorigenesis. We discuss here an additional novel mechanism that can operate between cancer cells and fibroblasts and which involves the release of the S1P receptor, S1P2 in exosomes from breast cancer cells that regulates ERK-1/2 signalling in fibroblasts. This novel mechanism of signalling might provide an explanation for the role of S1P2 in promoting metastasis of cancer cells and which is dependent on the micro-environmental niche.

      PubDate: 2018-05-31T22:07:18Z
      DOI: 10.1016/j.jbior.2017.09.006
      Issue No: Vol. 68 (2018)
       
  • How miRs and mRNA deadenylases could post-transcriptionally regulate
           expression of tumor-promoting protein PLD
    • Authors: Julian Gomez-Cambronero; Kristen Fite; Taylor E. Miller
      Pages: 107 - 119
      Abstract: Publication date: May 2018
      Source:Advances in Biological Regulation, Volume 68
      Author(s): Julian Gomez-Cambronero, Kristen Fite, Taylor E. Miller
      Phospholipase D (PLD) plays a key role in both cell membrane lipid reorganization and architecture, as well as a cell signaling protein via the product of its enzymatic reaction, phosphatidic acid (PA). PLD is involved in promoting breast cancer cell growth, proliferation, and metastasis and both gene and protein expression are upregulated in breast carcinoma human samples. In spite of all this, the ultimate reason as to why PLD expression is high in cancer cells vs. their normal counterparts remains largely unknown. Until we understand this and the associated signaling pathways, it will be difficult to establish PLD as a bona fide target to explore new potential cancer therapeutic approaches. Recently, our lab has identified several molecular mechanisms by which PLD expression is high in breast cancer cells and they all involve post-transcriptional control of its mRNA. First, PA, a mitogen, functions as a protein and mRNA stabilizer that counteracts natural decay and degradation. Second, there is a repertoire of microRNAs (miRs) that keep PLD mRNA translation at low levels in normal cells, but their effects change with starvation and during endothelial-to-mesenchymal transition (EMT) in cancer cells. Third, there is a novel way of post-transcriptional regulation of PLD involving 3′-exonucleases, specifically the deadenylase, Poly(A)-specific Ribonuclease (PARN), which tags mRNA for mRNA for degradation. This would enable PLD accumulation and ultimately breast cancer cell growth. We review in depth the emerging field of post-transcriptional regulation of PLD, which is only recently beginning to be understood. Since, surprisingly, so little is known about post-transcriptional regulation of PLD and related phospholipases (PLC or PLA), this new knowledge could help our understanding of how post-transcriptional deregulation of a lipid enzyme expression impacts tumor growth.

      PubDate: 2018-05-31T22:07:18Z
      DOI: 10.1016/j.jbior.2017.08.002
      Issue No: Vol. 68 (2018)
       
  • Roles of p53, NF-κB and the androgen receptor in controlling NGAL
           expression in prostate cancer cell lines
    • Authors: William H. Chappell; Saverio Candido; Stephen L. Abrams; Suzanne Russo; Roger Ove; Alberto M. Martelli; Lucio Cocco; Giulia Ramazzotti; Melchiorre Cervello; Giuseppe Montalto; Linda S. Steelman; Xiaohong Leng; Ralph B. Arlinghaus; Massimo Libra; James A. McCubrey
      Abstract: Publication date: Available online 18 May 2018
      Source:Advances in Biological Regulation
      Author(s): William H. Chappell, Saverio Candido, Stephen L. Abrams, Suzanne Russo, Roger Ove, Alberto M. Martelli, Lucio Cocco, Giulia Ramazzotti, Melchiorre Cervello, Giuseppe Montalto, Linda S. Steelman, Xiaohong Leng, Ralph B. Arlinghaus, Massimo Libra, James A. McCubrey
      Neutrophil gelatinase-associated lipocalin (NGAL a.k.a lipocalin 2, lnc2) is a secreted protein which can form a complex with matrix metalloproteinase-9 (MMP9). This MMP9/NGAL complex has been associated with metastasis. MMP9 and NGAL are detected in the urine of patients afflicted with many different types of cancer, including prostate cancer. The effects of p53, NF-κB and the androgen receptor (AR) on the expression of NGAL was examined in four prostate cancer cell lines. Prostate cancer cell lines that are AR negative and expressed either mutant or no p53 (DU145 and PC3) displayed higher levels of NGAL expression compared to the prostate cancer cell lines (LNCaP and 22Rv-1) which are AR positive and express wild type (WT) p53. Introduction of WT-p53 into the PC3 prostate cancer cell line, resulted in reduction of the levels of NGAL expression. Conversely, introduction of dominant negative (DN) p53 or a retroviral construct expressing NF-κB into LNCaP cells increased NGAL expression. NGAL expression had functional effects on the ability of the cells to form colonies in soft agar. Whereas suppression of WT-53 in LNCaP cells increased NGAL expression, the introduction of WT-p53 suppressed NGAL transcription activity in PC3 prostate cells which normally express high level of NGAL. NF-κB and p53 were determined to regulate NGAL expression by positive and negative mechanisms, respectively. Our data indicate that prostate cancer growth, progression and sensitivity to chemotherapeutic drugs are regulated in part by NGAL and may involve complex interactions between NGAL, MMP9, NF-κB and p53.

      PubDate: 2018-05-31T22:07:18Z
      DOI: 10.1016/j.jbior.2018.05.002
       
  • Nuclear organization mediates cancer-compromised genetic and epigenetic
           control
    • Authors: Sayyed K. Zaidi; Andrew Fritz; Kirsten Tracy; Jonathan Gordon; Coralee Tye; Joseph Boyd; Andre Van Wijnen; Jeffrey Nickerson; Anthony Imbalzano; Jane Lian; Janet Stein; Gary Stein
      Abstract: Publication date: Available online 9 May 2018
      Source:Advances in Biological Regulation
      Author(s): Sayyed K. Zaidi, Andrew Fritz, Kirsten Tracy, Jonathan Gordon, Coralee Tye, Joseph Boyd, Andre Van Wijnen, Jeffrey Nickerson, Anthony Imbalzano, Jane Lian, Janet Stein, Gary Stein
      Nuclear organization is functionally linked to genetic and epigenetic regulation of gene expression for biological control and is modified in cancer. Nuclear organization supports cell growth and phenotypic properties of normal and cancer cells by facilitating physiologically responsive interactions of chromosomes, genes and regulatory complexes at dynamic three-dimensional microenvironments. We will review nuclear structure/function relationships that include: 1. Epigenetic bookmarking of genes by phenotypic transcription factors to control fidelity and plasticity of gene expression as cells enter and exit mitosis; 2. Contributions of chromatin remodeling to breast cancer nuclear morphology, metabolism and effectiveness of chemotherapy; 3. Relationships between fidelity of nuclear organization and metastasis of breast cancer to bone; 4. Dynamic modifications of higher-order inter- and intra-chromosomal interactions in breast cancer cells; 5. Coordinate control of cell growth and phenotype by tissue-specific transcription factors; 6. Oncofetal epigenetic control by bivalent histone modifications that are functionally related to sustaining the stem cell phenotype; and 7. Noncoding RNA-mediated regulation in the onset and progression of breast cancer. The discovery of components to nuclear organization that are functionally related to cancer and compromise gene expression have the potential for translation to innovative cancer diagnosis and targeted therapy.

      PubDate: 2018-05-31T22:07:18Z
      DOI: 10.1016/j.jbior.2018.05.001
       
  • Foreword: “Current trends in cancer and signalling”
    • Authors: Pann-Ghill Suh
      Abstract: Publication date: Available online 11 April 2018
      Source:Advances in Biological Regulation
      Author(s): Pann-Ghill Suh


      PubDate: 2018-04-15T17:00:41Z
      DOI: 10.1016/j.jbior.2018.04.001
       
  • Dual inhibition of PI3K/mTOR signaling in chemoresistant AML primary cells
    • Authors: Jessika Bertacchini; Chiara Frasson; Francesca Chiarini; Daniele D'Avella; Benedetta Accordi; Laura Anselmi; Patrizia Barozzi; Fabio Foghieri; Mario Luppi; Alberto M. Martelli; Giuseppe Basso; Saki Najmaldin; Abbas Khosravi; Fakher Rahim; Sandra Marmiroli
      Abstract: Publication date: Available online 19 March 2018
      Source:Advances in Biological Regulation
      Author(s): Jessika Bertacchini, Chiara Frasson, Francesca Chiarini, Daniele D'Avella, Benedetta Accordi, Laura Anselmi, Patrizia Barozzi, Fabio Foghieri, Mario Luppi, Alberto M. Martelli, Giuseppe Basso, Saki Najmaldin, Abbas Khosravi, Fakher Rahim, Sandra Marmiroli
      A main cause of treatment failure for AML patients is resistance to chemotherapy. Survival of AML cells may depend on mechanisms that elude conventional drugs action and/or on the presence of leukemia initiating cells at diagnosis, and their persistence after therapy. MDR1 gene is an ATP-dependent drug efflux pump known to be a risk factor for the emergence of resistance, when combined to unstable cytogenetic profile of AML patients. In the present study, we analyzed the sensitivity to conventional chemotherapeutic drugs of 26 samples of primary blasts collected from AML patients at diagnosis. Detection of cell viability and apoptosis allowed to identify two group of samples, one resistant and one sensitive to in vitro treatment. The cells were then analyzed for the presence and the activity of P-glycoprotein. A comparative analysis showed that resistant samples exhibited a high level of MDR1 mRNA as well as of P-glycoprotein content and activity. Moreover, they also displayed high PI3K signaling. Therefore, we checked whether the association with signaling inhibitors might resensitize resistant samples to chemo-drugs. The combination showed a very potent cytotoxic effect, possibly through down modulation of MDR1, which was maintained also when primary blasts were co-cultured with human stromal cells. Remarkably, dual PI3K/mTOR inactivation was cytotoxic also to leukemia initiating cells. All together, our findings indicate that signaling activation profiling associated to gene expression can be very useful to stratify patients and improve therapy.

      PubDate: 2018-04-15T17:00:41Z
      DOI: 10.1016/j.jbior.2018.03.001
       
  • Phosphoinositide 3-kinase pathways and autophagy require
           phosphatidylinositol phosphate kinases
    • Authors: Suyong Choi; Xander Houdek; Richard A. Anderson
      Abstract: Publication date: Available online 8 February 2018
      Source:Advances in Biological Regulation
      Author(s): Suyong Choi, Xander Houdek, Richard A. Anderson
      Phosphatidylinositol phosphate kinases (PIPKs) generate a lipid messenger phosphatidylinositol 4,5-bisphosphate (PI4,5P2) that controls essentially all aspects of cellular functions. PI4,5P2 rapidly diffuses in the membrane of the lipid bilayer and does not greatly change in membrane or cellular content, and thus PI4,5P2 generation by PIPKs is tightly linked to its usage in subcellular compartments. Based on this verity, recent study of PI4,5P2 signal transduction has been focused on investigations of individual PIPKs and their underlying molecular regulation of cellular processes. Here, we will discuss recent advances in the study of how PIPKs control specific cellular events through assembly and regulation of PI4,5P2 effectors that mediate specific cellular processes. A focus will be on the roles of PIPKs in control of the phosphoinositide 3-kinase pathway and autophagy.

      PubDate: 2018-02-25T13:03:17Z
      DOI: 10.1016/j.jbior.2018.02.003
       
  • Application of HTLV-1 tax transgenic mice for therapeutic intervention
    • Authors: Hideki Hasegawa; Kaori Sano; Akira Ainai; Tadaki Suzuki
      Abstract: Publication date: Available online 13 February 2018
      Source:Advances in Biological Regulation
      Author(s): Hideki Hasegawa, Kaori Sano, Akira Ainai, Tadaki Suzuki
      Adult T-cell leukemia-lymphoma (ATL) is a refractory T-cell malignancy caused by infection of human T-cell leukemia virus type I (HTLV-I). Although the pathogenesis of ATL remains unclear, HTLV-1 oncoprotein Tax plays an important role in pathogenesis (Matsuoka, 2003; Jeang et al., 2004). Chemotherapy resistance of ATL leads the poor prognosis of this disease. In order to understand the pathogenesis and establish an animal model useful for therapy attempts, we have generated HTLV-1 Tax transgenic mice using the Lck proximal promoter to restrict the Tax expression in T-cells. The HTLV-1 Tax transgenic mice developed diffuse large-cell lymphomas and leukemia with the similar features of a clinical, pathological and immunological characteristic of acute ATL. The fulminant disease also developed rapidly in SCID mice after engraftment of mouse ATL cells derived from the transgenic mice. In this review, we introduce the therapeutic attempts using this animal model and discuss the possible signaling pathway for a therapeutic target.

      PubDate: 2018-02-15T11:06:49Z
      DOI: 10.1016/j.jbior.2018.02.004
       
  • Metformin influences drug sensitivity in pancreatic cancer cells
    • Authors: Saverio Candido; Stephen L. Abrams; Linda Steelman; Kvin Lertpiriyapong; Alberto M. Martelli; Lucio Cocco; Stefano Ratti; Matilde Y. Follo; Ramiro M. Murata; Pedro L. Rosalen; Paolo Lombardi; Giuseppe Montalto; Melchiorre Cervello; Agnieszka Gizak; Dariusz Rakus; Pann-Gill Suh; Massimo Libra; James A. McCubrey
      Abstract: Publication date: Available online 12 February 2018
      Source:Advances in Biological Regulation
      Author(s): Saverio Candido, Stephen L. Abrams, Linda Steelman, Kvin Lertpiriyapong, Alberto M. Martelli, Lucio Cocco, Stefano Ratti, Matilde Y. Follo, Ramiro M. Murata, Pedro L. Rosalen, Paolo Lombardi, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Pann-Gill Suh, Massimo Libra, James A. McCubrey
      Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5–10% after diagnosis and treatment. Pancreatic cancer has been associated with type II diabetes as the frequency of recently diagnosed diabetics that develop pancreatic cancer within a 10-year period of initial diagnosis of diabetes in increased in comparison to non-diabetic patients. Metformin is a very frequently prescribed drug used to treat type II diabetes. Metformin acts in part by stimulating AMP-kinase (AMPK) and results in the suppression of mTORC1 activity and the induction of autophagy. In the following studies, we have examined the effects of metformin in the presence of various chemotherapeutic drugs, signal transduction inhibitors and natural products on the growth of three different PDAC lines. Metformin, by itself, was not effective at suppressing growth of the pancreatic cancer cell lines at concentration less than 1000 nM, however, in certain PDAC lines, a suboptimal dose of metformin (250 nM) potentiated the effects of various chemotherapeutic drugs used to treat pancreatic cancer (e.g., gemcitabine, cisplatin, 5-fluorouracil) and other cancer types (e.g., doxorubicin, docetaxel). Furthermore, metformin could increase anti-proliferative effects of mTORC1 and PI3K/mTOR inhibitors as well as natural products such as berberine and the anti-malarial drug chloroquine in certain PDAC lines. Thus, metformin can enhance the effects of certain drugs and signal transduction inhibitors which are used to treat pancreatic and various other cancers.

      PubDate: 2018-02-15T11:06:49Z
      DOI: 10.1016/j.jbior.2018.02.002
       
  • Acknowledgements
    • Abstract: Publication date: January 2018
      Source:Advances in Biological Regulation, Volume 67


      PubDate: 2018-02-15T11:06:49Z
       
  • Foreword
    • Abstract: Publication date: January 2018
      Source:Advances in Biological Regulation, Volume 67


      PubDate: 2018-02-15T11:06:49Z
       
  • Group photo
    • Abstract: Publication date: January 2018
      Source:Advances in Biological Regulation, Volume 67


      PubDate: 2018-02-15T11:06:49Z
       
  • Key to Group photo
    • Abstract: Publication date: January 2018
      Source:Advances in Biological Regulation, Volume 67


      PubDate: 2018-02-15T11:06:49Z
       
  • Flimsy overlay to Group photo
    • Abstract: Publication date: January 2018
      Source:Advances in Biological Regulation, Volume 67


      PubDate: 2018-02-15T11:06:49Z
       
  • E.Dennis, Special lecturer photo
    • Abstract: Publication date: January 2018
      Source:Advances in Biological Regulation, Volume 67


      PubDate: 2018-02-15T11:06:49Z
       
  • The inflammatory microenvironment that promotes gastrointestinal cancer
           development and invasion
    • Authors: Kanae Echizen; Hiroko Oshima; Mizuho Nakayama; Masanobu Oshima
      Abstract: Publication date: Available online 5 February 2018
      Source:Advances in Biological Regulation
      Author(s): Kanae Echizen, Hiroko Oshima, Mizuho Nakayama, Masanobu Oshima
      Accumulating evidence has indicated that the inflammatory response is important for tumor promotion. However, the mechanisms underlying the induction of the inflammatory response in cancer tissues and how it promotes tumorigenesis remain poorly understood. We constructed several mouse models that develop inflammation-associated gastric and intestinal tumors and examined the in vivo mechanisms of tumorigenesis. Of note, the activation of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway and Toll-like receptor (TLR)/MyD88 signaling cooperatively induced the generation of an inflammatory microenvironment, which is required for early-stage tumorigenesis. The inflammatory response in the stroma induces TNF-α signaling in tumor cells, and the NOX1/ROS signaling pathway is activated downstream. In addition, the inflammatory pathway induces the expression of TLR2 in tumor epithelial cells. Both the NOX1/ROS and TLR2 pathways in tumor cells contribute to the acquisition and maintenance of stemness, which is an important tumor-promoting mechanism stimulated by inflammation. We also found that inflammation promotes malignant processes, like submucosal invasion, of TGF-β signaling-suppressed tumor cells through the activation of MMP2 protease. We also showed that mutant p53 induces innate immune and inflammatory signaling in the tumor stroma by a gain-of-function mechanism of mutant p53, which may explain the “cancer-induced inflammation” mechanism. These results indicate that the regulation of the inflammatory microenvironment via the inhibition of the COX-2/PGE2 and TLR/MyD88 pathways in combination may be an effective preventive or therapeutic strategy against gastrointestinal cancer development and malignant progression, especially those carrying p53 gain-of-function mutations.

      PubDate: 2018-02-05T10:52:45Z
      DOI: 10.1016/j.jbior.2018.02.001
       
  • Interaction of the Wnt/β-catenin and RAS-ERK pathways involving
           co-stabilization of both β-catenin and RAS plays important roles in the
           colorectal tumorigenesis
    • Authors: Sang-Kyu Lee; Jeong-Ha Hwang; Kang-Yell Choi
      Abstract: Publication date: Available online 10 January 2018
      Source:Advances in Biological Regulation
      Author(s): Sang-Kyu Lee, Jeong-Ha Hwang, Kang-Yell Choi
      Cancer development is usually driven by multiple genetic and molecular alterations rather than by a single defect. In the human colorectal cancer (CRC), series of mutations of genes are involved in the different stages of tumorigenesis. For example, the adenomatous polyposis coli (APC) and KRAS mutations have been known to play roles in the initiation and progression of the tumorigenesis, respectively. However, many studies indicate that mutations of these two genes, which play roles in the Wnt/β-catenin and RAS-extra-cellular signal regulated kinase (ERK) pathways, respectively, cooperatively interact in the tumorigenesis in several different cancer types including CRC. Both Apc and Kras mutations critically increase number and growth rate of tumors although single mutation of these genes did not significantly enhance the small intestinal tumorigenesis of mice. Both APC and KRAS mutations even result in the liver metastasis with inductions of the cancer stem cells (CSCs) markers in a mice xenograft model. In this review, we are going to describe the history for interaction between the Wnt/β-catenin and RAS/ERK pathways especially related with CRC, and provide the mechanical basis for the cross-talk between the two pathways. The highlight of the crosstalk involving the stability regulation of RAS protein via the Wnt/β-catenin signaling which directly related with the cellular proliferation and transformation will be discussed. Activation status of GSK3β, a key enzyme involving both β-catenin and RAS degradations, is regulated by the status of the Wnt/β-catenin signaling dependent upon extracellular stimuli or intracellular abnormalities of the signaling components. The levels of both β-catenin and RAS proteins are co-regulated by the Wnt/β-catenin signaling, and these proteins are overexpressed with a positive correlation in the tumor tissues of CRC patients. These results indicate that the elevation of both β-catenin and RAS proteins is pathologically significant in CRC. In this review, we also will discuss further involvement of the increments of both β-catenin and RAS especially mutant KRAS in the activation of CSCs and metastasis. Overall, the increments of β-catenin and RAS especially mutant KRAS by APC loss play important roles in the corporative tumorigenesis of CRC.

      PubDate: 2018-02-03T10:46:56Z
      DOI: 10.1016/j.jbior.2018.01.001
       
  • Advances in Biological Regulation
    • Abstract: Publication date: January 2018
      Source:Advances in Biological Regulation, Volume 67


      PubDate: 2018-02-03T10:46:56Z
       
  • Disrupting the ‘Warburg effect’ re-routes cancer cells to OXPHOS
           offering a vulnerability point via ‘ferroptosis’-induced cell death
    • Authors: Maša Ždralević; Milica Vučetić; Boutaina Daher; Ibtissam Marchiq; Scott K. Parks; Jacques Pouysségur
      Abstract: Publication date: Available online 28 December 2017
      Source:Advances in Biological Regulation
      Author(s): Maša Ždralević, Milica Vučetić, Boutaina Daher, Ibtissam Marchiq, Scott K. Parks, Jacques Pouysségur
      The evolution of life from extreme hypoxic environments to an oxygen-rich atmosphere has progressively selected for successful metabolic, enzymatic and bioenergetic networks through which a myriad of organisms survive the most extreme environmental conditions. From the two lethal environments anoxia/high O2, cells have developed survival strategies through expression of the transcriptional factors ATF4, HIF1 and NRF2. Cancer cells largely exploit these factors to thrive and resist therapies. In this review, we report and discuss the potential therapeutic benefit of disrupting the major Myc/Hypoxia-induced metabolic pathway, also known as fermentative glycolysis or “Warburg effect”, in aggressive cancer cell lines. With three examples of genetic disruption of this pathway: glucose-6-phosphate isomerase (GPI), lactate dehydrogenases (LDHA and B) and lactic acid transporters (MCT1, MCT4), we illuminate how cancer cells exploit metabolic plasticity to survive the metabolic and energetic blockade or arrest their growth. In this context of NRF2 contribution to OXPHOS re-activation we will show and discuss how, by disruption of the cystine transporter xCT (SLC7A11), we can exploit the acute lethal phospholipid peroxidation pathway to induce cancer cell death by ‘ferroptosis’.

      PubDate: 2018-01-03T19:51:58Z
      DOI: 10.1016/j.jbior.2017.12.002
       
  • Effects of berberine, curcumin, resveratrol alone and in combination with
           chemotherapeutic drugs and signal transduction inhibitors on cancer
           cells—Power of nutraceuticals
    • Authors: James McCubrey; Stephen Abrams Kvin Lertpiriyapong Lucio Cocco Stefano Ratti
      Abstract: Publication date: Available online 3 October 2017
      Source:Advances in Biological Regulation
      Author(s): James A. McCubrey, Stephen L. Abrams, Kvin Lertpiriyapong, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Saverio Candido, Massimo Libra, Ramiro M. Murata, Pedro L. Rosalen, Paolo Lombardi, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Linda S. Steelman
      Over the past fifty years, society has become aware of the importance of a healthy diet in terms of human fitness and longevity. More recently, the concept of the beneficial effects of certain components of our diet and other compounds, that are consumed often by different cultures in various parts of the world, has become apparent. These “healthy” components of our diet are often referred to as nutraceuticals and they can prevent/suppress: aging, bacterial, fungal and viral infections, diabetes, inflammation, metabolic disorders and cardiovascular diseases and have other health-enhancing effects. Moreover, they are now often being investigated because of their anti-cancer properties/potentials. Understanding the effects of various natural products on cancer cells may enhance their usage as anti-proliferative agents which may be beneficial for many health problems. In this manuscript, we discuss and demonstrate how certain nutraceuticals may enhance other anti-cancer drugs to suppress proliferation of cancer cells.

      PubDate: 2018-01-03T19:51:58Z
       
 
 
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