Publisher: Elsevier   (Total: 3147 journals)

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Showing 1 - 200 of 3147 Journals sorted alphabetically
Academic Pediatrics     Hybrid Journal   (Followers: 39, SJR: 1.655, CiteScore: 2)
Academic Radiology     Hybrid Journal   (Followers: 26, SJR: 1.015, CiteScore: 2)
Accident Analysis & Prevention     Partially Free   (Followers: 106, SJR: 1.462, CiteScore: 3)
Accounting Forum     Hybrid Journal   (Followers: 28, SJR: 0.932, CiteScore: 2)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 44, SJR: 1.771, CiteScore: 3)
Achievements in the Life Sciences     Open Access   (Followers: 7)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 6)
Acta Astronautica     Hybrid Journal   (Followers: 446, SJR: 0.758, CiteScore: 2)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 2)
Acta Biomaterialia     Hybrid Journal   (Followers: 30, SJR: 1.967, CiteScore: 7)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 3)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 12, SJR: 0.18, CiteScore: 1)
Acta Histochemica     Hybrid Journal   (Followers: 5, SJR: 0.661, CiteScore: 2)
Acta Materialia     Hybrid Journal   (Followers: 324, SJR: 3.263, CiteScore: 6)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.504, CiteScore: 1)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.542, CiteScore: 1)
Acta Oecologica     Hybrid Journal   (Followers: 12, SJR: 0.834, CiteScore: 2)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription  
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 2, SJR: 0.307, CiteScore: 0)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 2, SJR: 1.793, CiteScore: 6)
Acta Psychologica     Hybrid Journal   (Followers: 26, SJR: 1.331, CiteScore: 2)
Acta Sociológica     Open Access   (Followers: 1)
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.052, CiteScore: 2)
Acta Urológica Portuguesa     Open Access   (Followers: 1)
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3, SJR: 0.374, CiteScore: 1)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.344, CiteScore: 1)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 1)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 7, SJR: 0.19, CiteScore: 0)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 3)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 8)
Acute Pain     Full-text available via subscription   (Followers: 15, SJR: 2.671, CiteScore: 5)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.53, CiteScore: 4)
Addictive Behaviors     Hybrid Journal   (Followers: 18, SJR: 1.29, CiteScore: 3)
Addictive Behaviors Reports     Open Access   (Followers: 9, SJR: 0.755, CiteScore: 2)
Additive Manufacturing     Hybrid Journal   (Followers: 13, SJR: 2.611, CiteScore: 8)
Additives for Polymers     Full-text available via subscription   (Followers: 22)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 189, SJR: 4.09, CiteScore: 13)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 13, SJR: 1.167, CiteScore: 4)
Advanced Powder Technology     Hybrid Journal   (Followers: 17, SJR: 0.694, CiteScore: 3)
Advances in Accounting     Hybrid Journal   (Followers: 9, SJR: 0.277, CiteScore: 1)
Advances in Agronomy     Full-text available via subscription   (Followers: 17, SJR: 2.384, CiteScore: 5)
Advances in Anesthesia     Full-text available via subscription   (Followers: 30, SJR: 0.126, CiteScore: 0)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 2)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 12, SJR: 0.992, CiteScore: 1)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 12, SJR: 1.551, CiteScore: 4)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 24, SJR: 2.089, CiteScore: 5)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 15, SJR: 0.572, CiteScore: 2)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.61, CiteScore: 7)
Advances in Botanical Research     Full-text available via subscription   (Followers: 1, SJR: 0.686, CiteScore: 2)
Advances in Cancer Research     Full-text available via subscription   (Followers: 35, SJR: 3.043, CiteScore: 6)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 1.453, CiteScore: 2)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 1.992, CiteScore: 5)
Advances in Cell Aging and Gerontology     Full-text available via subscription   (Followers: 5)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 14)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 29, SJR: 0.156, CiteScore: 1)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 11, SJR: 0.713, CiteScore: 1)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 11, SJR: 1.316, CiteScore: 2)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 26, SJR: 1.562, CiteScore: 3)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 21, SJR: 1.977, CiteScore: 8)
Advances in Computers     Full-text available via subscription   (Followers: 14, SJR: 0.205, CiteScore: 1)
Advances in Dermatology     Full-text available via subscription   (Followers: 16)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 14)
Advances in Digestive Medicine     Open Access   (Followers: 13)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 7)
Advances in Drug Research     Full-text available via subscription   (Followers: 26)
Advances in Ecological Research     Full-text available via subscription   (Followers: 45, SJR: 2.524, CiteScore: 4)
Advances in Engineering Software     Hybrid Journal   (Followers: 30, SJR: 1.159, CiteScore: 4)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 9)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 51, SJR: 5.39, CiteScore: 8)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 2)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 9)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 68, SJR: 0.591, CiteScore: 2)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 17)
Advances in Genetics     Full-text available via subscription   (Followers: 21, SJR: 1.354, CiteScore: 4)
Advances in Genome Biology     Full-text available via subscription   (Followers: 12, SJR: 12.74, CiteScore: 13)
Advances in Geophysics     Full-text available via subscription   (Followers: 8, SJR: 1.193, CiteScore: 3)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 26, SJR: 0.368, CiteScore: 1)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 11, SJR: 0.749, CiteScore: 3)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 26)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 4, SJR: 0.193, CiteScore: 0)
Advances in Immunology     Full-text available via subscription   (Followers: 37, SJR: 4.433, CiteScore: 6)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 10, SJR: 1.163, CiteScore: 2)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 2, SJR: 1.938, CiteScore: 3)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6, SJR: 0.176, CiteScore: 0)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 3)
Advances in Life Course Research     Hybrid Journal   (Followers: 9, SJR: 0.682, CiteScore: 2)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 8)
Advances in Marine Biology     Full-text available via subscription   (Followers: 21, SJR: 0.88, CiteScore: 2)
Advances in Mathematics     Full-text available via subscription   (Followers: 17, SJR: 3.027, CiteScore: 2)
Advances in Medical Sciences     Hybrid Journal   (Followers: 9, SJR: 0.694, CiteScore: 2)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 5, SJR: 1.158, CiteScore: 3)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 26)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 8)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.182, CiteScore: 0)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 5)
Advances in Oncobiology     Full-text available via subscription   (Followers: 2)
Advances in Organ Biology     Full-text available via subscription   (Followers: 2)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 18, SJR: 1.875, CiteScore: 4)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.174, CiteScore: 0)
Advances in Parasitology     Full-text available via subscription   (Followers: 6, SJR: 1.579, CiteScore: 4)
Advances in Pediatrics     Full-text available via subscription   (Followers: 27, SJR: 0.461, CiteScore: 1)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 19)
Advances in Pharmacology     Full-text available via subscription   (Followers: 17, SJR: 1.536, CiteScore: 3)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 10, SJR: 0.574, CiteScore: 1)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.109, CiteScore: 1)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 11)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 6)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 19)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20, SJR: 0.791, CiteScore: 2)
Advances in Psychology     Full-text available via subscription   (Followers: 69)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 7, SJR: 0.371, CiteScore: 1)
Advances in Radiation Oncology     Open Access   (Followers: 3, SJR: 0.263, CiteScore: 1)
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.101, CiteScore: 0)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 7)
Advances in Space Research     Full-text available via subscription   (Followers: 431, SJR: 0.569, CiteScore: 2)
Advances in Structural Biology     Full-text available via subscription   (Followers: 6)
Advances in Surgery     Full-text available via subscription   (Followers: 13, SJR: 0.555, CiteScore: 2)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 37, SJR: 2.208, CiteScore: 4)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 20)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 15)
Advances in Virus Research     Full-text available via subscription   (Followers: 6, SJR: 2.262, CiteScore: 5)
Advances in Water Resources     Hybrid Journal   (Followers: 57, SJR: 1.551, CiteScore: 3)
Aeolian Research     Hybrid Journal   (Followers: 6, SJR: 1.117, CiteScore: 3)
Aerospace Science and Technology     Hybrid Journal   (Followers: 395, SJR: 0.796, CiteScore: 3)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.42, CiteScore: 2)
African J. of Emergency Medicine     Open Access   (Followers: 6, SJR: 0.296, CiteScore: 0)
Ageing Research Reviews     Hybrid Journal   (Followers: 12, SJR: 3.671, CiteScore: 9)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 489, SJR: 1.238, CiteScore: 3)
Agri Gene     Hybrid Journal   (Followers: 1, SJR: 0.13, CiteScore: 0)
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 18, SJR: 1.818, CiteScore: 5)
Agricultural Systems     Hybrid Journal   (Followers: 32, SJR: 1.156, CiteScore: 4)
Agricultural Water Management     Hybrid Journal   (Followers: 47, SJR: 1.272, CiteScore: 3)
Agriculture and Agricultural Science Procedia     Open Access   (Followers: 4)
Agriculture and Natural Resources     Open Access   (Followers: 3)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 58, SJR: 1.747, CiteScore: 4)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.589, CiteScore: 3)
Air Medical J.     Hybrid Journal   (Followers: 8, SJR: 0.26, CiteScore: 0)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.19, CiteScore: 0)
Alcohol     Hybrid Journal   (Followers: 12, SJR: 1.153, CiteScore: 3)
Alcoholism and Drug Addiction     Open Access   (Followers: 12)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 2, SJR: 0.604, CiteScore: 3)
Alexandria J. of Medicine     Open Access   (Followers: 1, SJR: 0.191, CiteScore: 1)
Algal Research     Partially Free   (Followers: 11, SJR: 1.142, CiteScore: 4)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.504, CiteScore: 1)
Allergology Intl.     Open Access   (Followers: 5, SJR: 1.148, CiteScore: 2)
Alpha Omegan     Full-text available via subscription   (SJR: 3.521, CiteScore: 6)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 11, SJR: 0.201, CiteScore: 1)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 55, SJR: 4.66, CiteScore: 10)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 6, SJR: 1.796, CiteScore: 4)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 6, SJR: 1.108, CiteScore: 3)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 5)
American Heart J.     Hybrid Journal   (Followers: 58, SJR: 3.267, CiteScore: 4)
American J. of Cardiology     Hybrid Journal   (Followers: 67, SJR: 1.93, CiteScore: 3)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 48, SJR: 0.604, CiteScore: 1)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 13)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 15, SJR: 1.524, CiteScore: 3)
American J. of Human Genetics     Hybrid Journal   (Followers: 40, SJR: 7.45, CiteScore: 8)
American J. of Infection Control     Hybrid Journal   (Followers: 29, SJR: 1.062, CiteScore: 2)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 37, SJR: 2.973, CiteScore: 4)
American J. of Medicine     Hybrid Journal   (Followers: 50)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3, SJR: 1.967, CiteScore: 2)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 265, SJR: 2.7, CiteScore: 4)
American J. of Ophthalmology     Hybrid Journal   (Followers: 67, SJR: 3.184, CiteScore: 4)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 5, SJR: 0.265, CiteScore: 0)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.289, CiteScore: 1)
American J. of Otolaryngology     Hybrid Journal   (Followers: 25, SJR: 0.59, CiteScore: 1)
American J. of Pathology     Hybrid Journal   (Followers: 32, SJR: 2.139, CiteScore: 4)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 30, SJR: 2.164, CiteScore: 4)
American J. of Surgery     Hybrid Journal   (Followers: 39, SJR: 1.141, CiteScore: 2)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.767, CiteScore: 1)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 7)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.144, CiteScore: 3)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 67, SJR: 0.138, CiteScore: 0)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 25, SJR: 0.411, CiteScore: 1)
Anales de Cirugia Vascular     Full-text available via subscription   (Followers: 1)
Anales de Pediatría     Full-text available via subscription   (Followers: 3, SJR: 0.277, CiteScore: 0)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription  
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 6, SJR: 4.849, CiteScore: 10)
Analytica Chimica Acta     Hybrid Journal   (Followers: 44, SJR: 1.512, CiteScore: 5)
Analytica Chimica Acta : X     Open Access  
Analytical Biochemistry     Hybrid Journal   (Followers: 214, SJR: 0.633, CiteScore: 2)
Analytical Chemistry Research     Open Access   (Followers: 13, SJR: 0.411, CiteScore: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 14)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 2)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 25, SJR: 0.683, CiteScore: 2)
Angiología     Full-text available via subscription   (SJR: 0.121, CiteScore: 0)
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1, SJR: 0.111, CiteScore: 0)
Animal Behaviour     Hybrid Journal   (Followers: 238, SJR: 1.58, CiteScore: 3)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 8, SJR: 0.937, CiteScore: 2)
Animal Reproduction Science     Hybrid Journal   (Followers: 7, SJR: 0.704, CiteScore: 2)
Annales d'Endocrinologie     Full-text available via subscription   (Followers: 3, SJR: 0.451, CiteScore: 1)

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Similar Journals
Journal Cover
Advances in Integrative Medicine
Journal Prestige (SJR): 0.176
Number of Followers: 6  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Online) 2212-9588
Published by Elsevier Homepage  [3147 journals]
  • Appetite and weight control by Hypericum perforatum and acupuncture added
           
    • Abstract: Publication date: Available online 22 January 2020Source: Advances in Integrative MedicineAuthor(s): Monirsadat Sahebkar-Khorasani, Mohammad Safarian, Lida Jarahi, Mahdi Yousefi, Roshanak Salari, Hoda AziziAbstractIntroductionTo compare the effects ofHypericum perforatum with lifestyle modification and acupuncture for appetite and weight control in obese or overweight patients.MethodsThe planned sample size is 88. Participants in group I will receive electroacupuncture, Hypericum perforatum, and lifestyle modification; group II, electroacupuncture, placebo, and lifestyle modification; group III, sham electroacupuncture, Hypericum perforatum, and lifestyle modification, group IV, sham electroacupuncture, placebo, and lifestyle modification.The primary outcome is change in serum nesfatin-1 level at week 6 comparing to baseline. Secondary outcomes include appetite score and anthropometric indices. Outcomes will be assessed at baseline, week 2,6, 12 and 24. The statistical analyses will be performed using SAS and SPSS version with a 2-sided P value of less than 0.05 considered statistically significant.ConclusionsBy implementing placebo for both Hypericum perforatum and acupuncture, this study may help improving the methodology of comparative effectiveness studies of different complementary medicine interventions.
       
  • Natural Killer Cell Function Changes by the Japanese Kampo Medicine
           Juzentaihoto in General Fatigue Patients
    • Abstract: Publication date: Available online 7 January 2020Source: Advances in Integrative MedicineAuthor(s): Keiko Ogawa-Ochiai, Takamasa Katagiri, Yuki Sato, Akiko Shirai, Ken Ishiyama, Akiyoshi Takami, Eriko MorishitaBackgroundPhysical/mental fatigue can alter behavior and reduce cognitive abilities. Even in healthy people, general fatigue correlates with NK cell function. Juzentaihoto (JTT) is a popular Kampo medicine used to treat general fatigue. In many animal models, JTT enhances immune functions, such as cytotoxic T-lymphocyte and NK cell activities. This is the first clinical study has examined the effect of JTT in patients with general fatigue.PurposeWe investigated whether peripheral NK cell populations and functions are altered by JTT treatment in patients with general fatigue.Patients and MethodsThe open-label unblinded study included ten patients (two males, eight females; median age 36.5 years, range 29–46 years) with general fatigue (Performance Status, PS 0–2) and. As controls, six healthy volunteers (two males, four females; median age [range]: 39 [36–45] years) were also enrolled in this study and provided informed consent before sampling. All patients were administered JTT three times per day before each meal for 28 consecutive days and were evaluated twice weekly for 42 days to assess compliance and adverse events. The primary endpoint was fatigue score obtained by a subjective numerical rating scale and PS. The secondary endpoint was the effects of JTT on circulating lymphocytes based on the expression of surface receptors in specific lymphocytic subsets.ResultsExpression of activation markers significantly increased from day 0 to 28 and decreased after 42 days. Inhibitory markers were upregulated in the cluster of high cytokine-producing ability but were downregulated in the fraction with high cytotoxicity. Increased expression of functional markers was observed following interleukin-2 stimulation in vitro.ConclusionsJTT induces cytotoxic activity of NK cells. NK cells may maintain a balanced state by increasing inhibitory functions. Oral administration of JTT may improve immune function by activating NK cells.Graphical abstractGraphical abstract for this article
       
  • Vitamin E and ginseng combined supplement for treatment of male erectile
           dysfunction: a double-blind, placebo-controlled, randomized, clinical
           trial
    • Abstract: Publication date: Available online 23 December 2019Source: Advances in Integrative MedicineAuthor(s): Borna Tadayon Najafabadi, Morteza Jafarinia, Kiandokht Ghamari, Kamyar Shokraee, Farhad Tadayyon, Shahin AkhondzadehAbstractBackgroundErectile dysfunction (ED) is among the most common sexual dysfunctions affecting the male population over 40 years old. The first line of treatment for this condition is phosphodiesterase 5 inhibitors. Although these drugs are very effective, some patients are reluctant to use them due to their side effects or patient unresponsiveness. We hypothesized that a supplement of vitamin E and ginseng, due to anti-oxidative properties, can ameliorate erectile dysfunction.ObjectiveThis study aimed to evaluate the effect of vitamin E and ginseng supplement to enhance erectile function among patients with erectile dysfunction.MethodsIn a six-week, double-blind, parallel-group, placebo-controlled trial, patients between 18 to 60 years of age, with erectile dysfunction based on the international index of erectile function (IIEF) questionnaire, were equally randomized to receive daily supplement of vitamin E and ginseng (100 IU vitamin E, 67 mg Korean ginseng, and 40 mg Siberian ginseng) or placebo. Participants were evaluated for erectile dysfunction with the IIEF scale and adverse event on the second, fourth, and sixth week. Analysis of variance was used to compare groups in terms of erectile function.ResultsFifty-two participants were randomly allocated to the groups and all finished the trial. Participants in our groups did not differ significantly in their baseline variables. After six weeks, the analysis revealed a significant improvement of erectile function in the supplement group over the placebo group (p-value = 0.033). Other domains of sexual function did not show significant difference between the groups. Adverse events profile of the supplement group was clinically acceptable and similar to the placebo group.ConclusionOur results revealed that the vitamin E and ginseng combined supplement can improve erectile function after six weeks while maintaining a safe and acceptable adverse event profile. Further trials with longer follow-up time and bigger population is still suggested.
       
  • Cinnamomum tamala as an adjuvant therapy in the treatment of major
           depressive disorder: a double-blind, randomized, placebo-controlled
           clinical trial with placebo control
    • Abstract: Publication date: Available online 16 December 2019Source: Advances in Integrative MedicineAuthor(s): Salomeh Ghaffari, Ali Ghobadi, Amir Hossein Jamshidi, Seyyed Hosein Mortazavi, Sina Naderi, Ali Aqamolaei, Amirhosein Mortezaei, Erfan Sahebolzamani, Ahmad Shamabadi, Shakiba Jalilvand, Bahram Daraei, Mohammad Reza Shalbafan, Shahin AkhondzadehAbstractAimMajor depressive disorder (MDD) is one the most common diseases in the world and about one-third to one-half of the patients don’t respond to routine treatment. Thus, the role of alternative medicines, like herbal drugs, is important. The aim of this present randomized, double-blind, placebo-controlled, 6-week trial was to assess the efficacy and tolerability of Cinnamomum tamala as an adjuvant to sertraline in treatment of patients with MDD.MethodsIn a randomized double-blind clinical trial, 50 patients diagnosed with major depressive disorder (MDD) based on DSM V, were assigned into two parallel groups to receive sertraline (100 mg twice a day) plus placebo or sertraline (100 mg twice a day) plus Cinnamomum tamala (500 g daily) for 6 weeks. Patients were evaluated for response to treatment using the HAM-D score at baseline and at weeks 2, 4 and 6. The main outcome measure was to assess the efficacy of C. tamala in improving the MDD symptoms.ResultsForty-two patients completed the trial. Repeated-measure analysis of variance showed a significant effect for time × treatment interaction (Greenhouse-Geisser corrected: F = 5.12, df = 2.19, p-value = 0.006) in HAM-D score. There was significant improvement in HAM-D score of the C. tamala group compared with the placebo group from baseline to weeks 2, 4 and 6. [Ps = 0.012, 0.008 and 0.009; respectively]. The frequency of adverse effects was similar between the two groups.ConclusionThe results of this study suggest that Cinnamomum tamala is effective as an adjuvant agent in the treatment of MDD.
       
  • Effect of 6 months of yoga practice on quality of life among patients with
           asthma: A randomized control trial
    • Abstract: Publication date: December 2019Source: Advances in Integrative Medicine, Volume 6, Issue 4Author(s): Malarvizhi M., Maheshkumar K., Bhavani M., Hariprasad B.AbstractIntroductionAs a holistic therapy, yoga has the potential to relieve both the physical and psychological sufferings of people with asthma. This study was conducted to assess the effectiveness of yoga therapy as an adjunctive tool in the management of mild to moderate asthma with the routine conventional care.MethodsA total of 250 adult patients with mild to moderate (FEV1 > 60%) bronchial asthma were recruited from the respiratory medicine department and randomly allocated to either the yoga (intervention) group (n = 125) or control group (n = 125). All patients remained on their usual care, while the yoga group received an intervention based on yoga, in addition to usual care. The intervention consisted of 2-weeks supervised training on yoga followed by a closely monitored continuation of the practices at home for 6 months. Quality of life was assessed using Asthma Quality of Life Questionnaire (AQOL) at baseline, 3rd month and after the 6 months interval for both the group patients.ResultsThe baseline characteristics were similar in both groups. Post-intervention, the yoga group (130.48 ± 12.43) showed better trends of improvement in total AQOL score than the control group (78.82 ± 4.37). In comparison to the various domains in AQOL such as symptoms (P 
       
  • Investigating the effect of listening to the Holy Quran on the
           physiological responses of neonates admitted to neonatal intensive care
           units: A pilot study
    • Abstract: Publication date: December 2019Source: Advances in Integrative Medicine, Volume 6, Issue 4Author(s): Arina Qolizadeh, Zahra Tayebi Myaneh, Farnoosh RashvandAbstractAimThe purpose of this study is to investigate the effect of listening to the Holy Quran on the physiological responses of neonates admitted to neonatal intensive care units.MethodsThe present clinical trial was conducted in Iran. The study sample consisted of 64 preterm neonates admitted to the neonatal intensive care units (32 of whom were in the Quranic voice group that listened to voice of Quran and 32 in the control group). Neonates’ physiological responses including heart rate, respiratory rate, arterial oxygen saturation percentage, mean arterial pressure and temperature were recorded every 10 min in three stages: immediately before the intervention, during the intervention (minutes 10 and 20 from the onset of intervention) and 10 min after the intervention.ResultsAccording to the findings during the intervention and 10 min after the intervention, the mean heart rate of the neonates in the intervention group was significantly lower. The results of this study demonstrated that the mean respiratory rate of neonates was significantly less in the intervention group during the intervention (P 
       
  • Naturopathic medical student empathy and burnout: A preliminary study
    • Abstract: Publication date: December 2019Source: Advances in Integrative Medicine, Volume 6, Issue 4Author(s): Matthew Hicks, Douglas HanesAbstractBackgroundMany studies have demonstrated empathy decline in medical students over the course of training. Burnout negatively affects academic or professional performance and has been negatively correlated with empathy. Neither empathy nor burnout has been previously studied in naturopathic medical students.ObjectiveThe aims of this cross-sectional study were to (1) compare empathy at different levels of training, (2) describe the prevalence of burnout, and (3) identify correlations between empathy and burnout, in naturopathic medical students.MethodsThis cross-sectional study used the Interpersonal Reactivity Index and Maslach Burnout Inventory to measure empathy and burnout, respectively, in an online survey of current naturopathic medical students at one institution.Results1) There was no significant difference in empathy between any cohorts or between those in internship versus those not in internship. 2) Among burnout outcomes, 42% of participants met criteria for emotional exhaustion, 19% for depersonalization, and 64% for low sense of personal accomplishment. 3) Cognitive empathy was positively correlated with affective empathy and a higher sense of personal accomplishment and negatively correlated with emotional exhaustion and depersonalization.ConclusionsWhile a longitudinal study would provide more definitive evidence, this study suggests that empathy in naturopathic medical students is relatively stable over the course of training. It also demonstrates that burnout is prevalent in this population and has an inverse relationship with empathy. Interventions to prevent burnout and increase empathy are discussed.
       
  • Exploration and evaluation of the tools used to identify first year
           at-risk students in health science courses: A systematic review
    • Abstract: Publication date: December 2019Source: Advances in Integrative Medicine, Volume 6, Issue 4Author(s): Tirtha Goradia, Andrea BugarcicAbstractObjectivesHigh attrition rate in first year health science courses including allied health is a common problem in the higher education sector. This systematic review aims to explore the tools used by educators in identifying first year, at-risk students studying health science courses within higher education. The review identifies the tools and investigates their effectiveness in identifying at-risk students.MethodsA mixed-methods systematic review of original research was undertaken exploring the tools used or developed for identification of the at-risk health science students in their first year of study. Following databases were searched: Academic OneFile, CINAHL PLUS, ERIC, ScienceDirect and Google Scholar.ResultsCollectively, the included studies (n = 13) revealed that a combination of both academic and non-academic factors are most effective in identifying at-risk students. All 13 identified studies developed tools based on one or more of the following three categories: those examining the personal background, academic preparedness and the student perceptions of their own abilities and readiness.ConclusionWith students enrolling into health science courses coming from various diverse academic and personal backgrounds, the tools identified in this systematic review could enhance early identification of at-risk students, thereby enabling educational institutions to take timely educational interventions to support them.
       
  • Traditional evidence is becoming increasingly recognised, but inequity
           abounds
    • Abstract: Publication date: December 2019Source: Advances in Integrative Medicine, Volume 6, Issue 4Author(s): Jon Wardle
       
  • An open-label randomized pragmatic non-inferiority pilot trial comparing
           the effectiveness of Curare 30CH against individualized homeopathic
           medicines in post-stroke hemiparesis
    • Abstract: Publication date: Available online 11 June 2019Source: Advances in Integrative MedicineAuthor(s): Jaytilak Pramanick, Usha Uchat, Abhijit Chattopadhyay, Anaitulah Ahmad Mir, Munmun Koley, Subhranil SahaAbstractBackgroundPost-stroke hemiparesis is the most common complication following stroke. Due to unsatisfactory results from conventional treatment, alternative treatments including homeopathy are increasingly becoming popular. Curare is the one of the recommended homeopathic medicine prescribed on ‘common symptoms’ of motor paralysis, but has not been researched systematically. We hypothesized that Curare 30CH would be non-inferior to individualized homeopathy (IH) in treatment of post-stroke hemiparesis in the context of standard physiotherapy.MethodsAn open, randomized (1:1), exploratory, two parallel arms, pragmatic, non-inferiority, pilot trial was conducted at the Homoeopathic Materia Medica out-patient departments of National Institute of Homoeopathy (NIH), India on 50 patients comparing the effectiveness of Curare 30CH against IH. Comparative analysis was carried out on the primary outcome to detect non-inferiority by one-tailed t test at alpha = 5% with a prefixed margin (Δ) of 1.0 based on assumption. Oxford muscle strength grading scale and stroke impact scale (SIS) questionnaires were the primary and secondary outcomes respectively; assessed at baseline, after 3 and 6 months of treatment.ResultsFive subjects dropped out (Curare: 3, IH: 2). Groups were comparable at baseline (all P > 0.01). In both groups, both the outcomes improved significantly after 3 and 6 months. Non-inferiority was demonstrated by Curare 30CH against IH, both over 3 months (mean difference = 0.04, lower 95% confidence limit −0.195, t = 7.429, P 
       
  • The effect of P6 acupressure on nausea and vomiting of pregnancy: A
           randomized, single-blind, placebo-controlled trial
    • Abstract: Publication date: Available online 4 November 2019Source: Advances in Integrative MedicineAuthor(s): Sedigheh Sedigh Mobarakabadi, Samira Shahbazzadegan, Giti OzgoliAbstractBackgroundNausea and vomiting of pregnancy are common complaints that affect the quality of life significantly, even in mild cases. Although pharmacological treatments are available for these ailments, concerns about their effects on fetal health make healthcare providers and recipients prefer non-pharmacological therapies.ObjectivesThis study examines the effect of Pericardium 6 (P6) acupressure with Sea-Band on the severity and frequency of nausea and vomiting of pregnancy and compares it with a placebo and a control group.Design and participantsIn this randomized, single-blind, placebo-controlled trial, 75 pregnant women with symptoms of mild to moderate nausea and vomiting of pregnancy with a gestational age of
       
  • Effect of banana leaf bath (a type of heliotherapy) on short-term heart
           rate variability changes in healthy individuals: A pilot study
    • Abstract: Publication date: Available online 29 October 2019Source: Advances in Integrative MedicineAuthor(s): M. Fathima-Jebin, A. Mooventhan, K. Maheshkumar, N. ManavalanAbstractIntroductionBanana leaf bath (BLB) [a type of heliotherapy (sunbath)] is being used in various diseases like skin diseases, obesity and other metabolic disorders in many naturopathy hospitals in India. However, its precise physiology is less understood. Thus, this study was conducted to evaluate the effect of BLB on heart rate variability (HRV) in healthy individuals.Materials and MethodsTwenty-eight (12 males, 16 females) healthy individuals with the mean (standard deviation) age of 23.39 (3.70) years were recruited. All the subjects underwent a 30 minutes session of BLB (lie down in a place with direct sunlight exposure while covering the entire body with banana leaves). Assessments were taken before and after the intervention.ResultsResults of this study showed a significant increase in the mean of the intervals between adjacent QRS complexes or the instantaneous HR (RR Intervals), standard deviation of RR Intervals (SDNN), the square root of the mean of the sum of the squares of differences between adjacent normal-to-normal (NN) intervals (RMSSD), the number of interval differences of successive NN intervals>50 ms (NN50), and the proportion derived by dividing NN50 by the total number of NN intervals (pNN50) and a significant reduction in heart rate (HR), while no significant difference in low frequency (LF), high-frequency (HF) and LF/HF ratio in the study group.ConclusionResults of this study suggest that 30 minutes of BLB might be effective in reducing HR and in improving HRV towards vagal dominance in healthy individuals.
       
  • The interaction of FTO-rs9939609 polymorphism with artichoke leaf extract
           effects on cardiometabolic risk factors in hypertriglyceridemia: A
           randomized clinical trial
    • Abstract: Publication date: September 2019Source: Advances in Integrative Medicine, Volume 6, Issue 3Author(s): Khatereh Rezazadeh, Mohammad Asghari-Jafarabadi, Mehranghiz Ebrahimi-MameghaniAbstractObjectiveHypertriglyceridemia is associated with an increased risk of cardiovascular disease. The potential favorable effects of artichoke leaf extract (ALE) on anthropometric and metabolic indices may affect by fat mass and obesity associated (FTO)-rs9939609 polymorphism. This study was designed to evaluate the effects of ALE supplementation on cardiometabolic risk factors in hypertriglyceridemic patients regarding the interaction of rs9939609-FTO polymorphism with intervention outcomes.MethodsIn this double-blind placebo-controlled randomized clinical trial, 52 patients with hypertriglyceridemia randomly allocated to receive ALE (1800 mg/day as four tablets) or matching placebo (consisting of corn starch, lactose, and avicel) for 12 weeks. The measurement of anthropometric indices, fasting blood sugar (FBS), and lipid profile was performed before and after the intervention. The FTO-rs9939609 polymorphism was genotyped by polymerase chain reaction-restriction length polymorphism (PCR-RFLP). The interaction was tested using two-way ANOVA.ResultsForty-eight patients completed the trial (intervention, n = 24, placebo = 24). ALE and placebo groups were similar in the baseline characteristics. ALE supplementation did not change anthropometric indices and metabolic parameters. However, there was a significant interaction between FTO-rs9939609 polymorphism and TC, LDL-C, and TG level response to ALE supplementation. Moreover, significant changes in TG level were observed in A allele carriers compared to subjects with TT genotype.ConclusionNo significant effect of ALE supplementation was shown on anthropometric and biochemical indices in Iranian hypertriglyceridemic patients. However, rs9939609 variant of FTO gene seems to affect lipid profile response to ALE supplementation. Further clinical trials with larger sample size are suggested to clarify the possible interaction between rs9939609 variant or other variants of FTO gene and ALE supplementation in hypertriglyceridemia.
       
  • Interpreting the language of traditional medicine
    • Abstract: Publication date: September 2019Source: Advances in Integrative Medicine, Volume 6, Issue 3Author(s): Jon Wardle
       
  • The Effects of Hegu Point Ice Massage on Post-Sternotomy Pain in Patients
           Undergoing Coronary Artery Bypass Grafting: A Single–Blind, Randomized,
           Clinical Trial
    • Abstract: Publication date: Available online 20 August 2019Source: Advances in Integrative MedicineAuthor(s): Tahereh Taherian, Seyed Afshin Shorofi, Amir Emami Zeydi, Jamshid Yazdani Charati, Zahra Pouresmail, Hedayat JafariAbstractBackground and purposePain is considered as one of the most common problems among patients undergoing open heart surgery. We aimed to evaluate the effects of Hegu point ice massage on the level of pain experienced after coronary artery bypass graftingMaterials and MethodsThis is a single–blind, randomized, clinical trial, conducted on 80 patients who were recruited via convenience sampling method. The sample was randomly divided into two groups. In the experimental group, ice massage was performed at the Hegu point on the left hand by applying a medium pressure for 10 minutes (2 minutes massage, 15 seconds rest) in postoperative day 1 and 2. In the control group, glass marbles were applied at the Hegu point on the left hand with no pressure and massage for 10 minutes. Pain intensity was measured in both groups before the intervention and at 30, 60, and 120 minutes following the intervention.ResultsFollowing the intervention on the postoperative day 1, the mean pain score for the experimental and control groups was 2.97 ± 1.40 and 3.64 ± 1.56, respectively. For the experimental and control groups on postoperative day 2, the mean pain score was 2.35 ± 1.12 versus 3.03 ± 1.40, respectively. Following the intervention on postoperative day 1, the mean pain score was 2.97 ± 1.40 and 3.64 ± 1.56 in the experimental and control groups, respectively. The mean pain score for the experimental group was 2.35 ± 1.12 compared with 3.03 ± 1.40 for the control group after the intervention on the second postoperative day. Statistically significant differences were revealed for the mean pain score between the two groups after the intervention on the first (p = 0.04) and second (p = 0.02) postoperative days.ConclusionHegu point ice massage is an effective method for relieving pain associated with coronary artery bypass grafting in specific patients.
       
  • MANAGEMENT OF TASALLUBE SHARAIN (PERIPHERAL ARTERY DISEASE) BY
           HIRUDOTHERAPY: A CASE REPORT
    • Abstract: Publication date: Available online 2 August 2019Source: Advances in Integrative MedicineAuthor(s): Samreen Ilyas, Hamid Ali, Zoheb Alam KhanAbstractBackgroundPeripheral artery disease (PAD) is one of the major causes of morbidity and mortality which results from blockage of the arteries that provide blood flow to the upper and lower extremities. The primary underlying cause is usually atherosclerosis. In Unani System of Medicine, atherosclerosis has been described under the caption of Tasallube Sharain which results from accumulation of abnormal black bile in the blood vessels. Conventional system of medicine offers several medications and surgeries to manage PAD but there is limited clinical evidence for its effectiveness. Hence, this can be managed well by one of the Unani regimens i.e.Irsale Alaq (Hirudotherapy).ObjectiveThe purpose of this case report is to provide insight into the effects of Irsale Alaq (Hirudotherapy) in Tasallube Sharain (peripheral artery disease).InterventionA 46-year-old female who has complaints of pain and numbness with blackish discoloration in the distal tip of the middle finger of her right hand and was diagnosed Peripheral Artery Disease. After assessment, the right hand of the patient was cleansed and leeches (Hirudo medicinalis) were applied. Based on hemoglobin status and capillary refilling test, about 2 sittings of Irsale Alaq (hirudotherapy) were done in a week for about two weeks. Patient came for follow ups till 6 months but there was no re-occurrence of any of the signs and symptoms again.ResultsWith leech therapy, the symptoms of the patient i.e. the size of the lesion reduce with subsequent sittings of Irsale Alaq (Hirudotherapy).ConclusionOn the basis of results of the present case, it appears that such cases of Tasallube Sharain (Peripheral Artery Disease) can be cured with Irsale Alaq (Hirudotherapy) and can improve the quality of life with a relative long-term clinical efficacy in such patients.
       
  • Antioxidant supplementation may support reduction in pelvic pain in
           endometriosis
    • Abstract: Publication date: Available online 30 July 2019Source: Advances in Integrative MedicineAuthor(s): M. East-Powell, R. ReidAbstractDesignRandomised, placebo-controlled trial.ParticipantsWomen included in this trial were aged between 19 and 41 years and were recruited from Emory Clinic and Crawford Long Hospital, affiliated to Emory University School of Medicine in Atlanta, Georgia. The inclusion criteria included women with pelvic pain and a history of endometriosis and/or infertility. A total of 59 women were included in the trial.InterventionThe total of 59 women were randomised into one of the two research arms of group A (n = 46) given vitamin E and vitamin C combinations or group B (n = 13) placebo pills. The interventions involved vitamin E 1200 IU (3 capsules of 400 mg each) and vitamin C 1000 mg (2 tablets of 500 mg each) daily for eight weeks prior to surgery.ComparatorA placebo arm of 13 women with endometriosis and/or infertility.Major outcomes1 A reduction of inflammation markers interleukin 6 and monocyte-chemotactic protein-1 after eight weeks in the intervention arm was observed.2 Vitamin E and C intervention arms reduced chronic pelvic pain.3 Vitamin C is recommended to be supplemented with vitamin E due to vitamin C’s ability to regenerate vitamin E following oxidation.SettingsEmory University School of Medicine, Atlanta, Georgia, United States of America.ConclusionThis trial identified that daily antioxidant supplementation with vitamin E and vitamin C for a period of eight weeks showed significance in reducing peritoneal inflammatory markers, which may be responsible for the development of pain in endometriosis. The trial also demonstrated that combination supplementation of vitamin E and vitamin C lowered chronic pelvic pain in women with endometriosis. The findings indicate that supplementation with nutritional medicines that interact with inflammatory processes may be of benefit to women with endometriosis and may be used in conjunction with other treatment regimens from their health care provider.
       
  • The prevalence and characteristics of complementary medicine use by
           Australians living with sleep disorders – Results of a cross-sectional
           study
    • Abstract: Publication date: Available online 19 February 2019Source: Advances in Integrative MedicineAuthor(s): Vibha Malhotra, Joanna Harnett, Erica McIntyre, Amie Steel, Keith Wong, Bandana SainiAbstractObjectivesTo report the prevalence and characteristics of complementary medicine use and product utilization by Australians living with sleep disorders.DesignA cross-sectional study.Methods2025 adults representative of the Australian population by age, gender and state/territory of residence completed a survey consisting of 50 items including demographic, health services and complementary product/service utilization and health status items. The sociodemographic characteristics, prevalence and frequency of complementary medicine (CM) use, and out of pocket CM expenses were compared between those reporting a sleep disorder to those without a sleep disorder.ResultsOf the 2019 respondents completing the online survey, 265 (13%) reported sleep disorders. Of these 265 respondents, the median age bracket was 40–50 years; 54.7% were females. The mean health-related quality of life score in this group was 44.8 ± 23.3; the group had a higher level of comorbid conditions compared to those without sleep disorders (p 
       
  • Correlation between tongue body colour, as quantified by machine learning,
           and clinical indices
    • Abstract: Publication date: Available online 18 February 2019Source: Advances in Integrative MedicineAuthor(s): Tadaaki Kawanabe, Mieko Tanigawa, Sachiko Kakizaki, Nur Diyana Kamarudin, Xiaoyu Mi, Toshihiko Hanawa, Hiroshi OdaguchiAbstractObjectivesEvaluation of tongue colour is an important approach for assessment of human health in traditional East Asian medicine, which originated in ancient China. However, tongue colour analyses are unreliable due to poor quantification and reproducibility. Given these limitations, the utility of this technique as a clinical index has not been demonstrated. Here, we assessed whether tongue colour evaluations, as performed in Kampo (traditional Japanese) medicine, via an automated image acquisition system were associated with particular indices of patient health.MethodsWe obtained high colour reproduction tongue images from 816 Japanese subjects and applied a machine-learning analysis approach to the quantification of tongue body colour in them. Data on sex, age, systolic blood pressure, diastolic blood pressure, pulse rate (PR), body temperature, body mass index (BMI), past medical history (PMH), and blood examination results (haemoglobin, Hb; creatinine) were also collected.ResultsTongue body colour was influenced by multiple clinical indices, per simple correlation analyses. In particular, sex, age, BMI, PR, and Hb were correlated with tongue body colour. No significant correlation with PMH was found.ConclusionsTongue body colour, as quantified with a machine learning approach, was found to be a clinical predictor of changes in several clinical indices, particularly those related to obesity and haemoglobin concentrations.
       
  • Verifying the validity of urinary kryptopyrrole (UKP) testing in an adult
           population: Protocol for a multi-stage research project
    • Abstract: Publication date: Available online 16 February 2019Source: Advances in Integrative MedicineAuthor(s): Amie Steel, Jason Rainforest, Janet SchlossAbstractIntroductionUrinary kryptopyrroles (UKP) are described as pyrrole compounds excreted in urine and have been associated with a broad range of signs and symptoms. However, causality between elevated UKP and the described symptoms of pyrrole disorder have not been established. A four stage project has been developed to verify the validity of a urinary kryptopyrroles test and attempt to establish a reference range for a healthy population.MethodsStage one will consist of a survey to clinicians who are currently using UKP testing in their practice to understand their perceptions of the clinical value and applicability of the test in addition to identifying the condition for stage three. Stage two consists of a clinical trial to establish a normal reference range for UKP in a healthy population. Stage three is a clinical trial exploring the correlation, if any, between UKP in a diagnosed health condition to the healthy population group. Stage four is a pragmatic trial assessing UKP levels in patients as used by clinicians as part of routine clinical practice.RecruitmentRecruitment for stage one will be via email invitation to SAFE Analytical laboratories Pty Ltd customer database. Stage two and three will be targeting the wider community in the greater Brisbane area in Queensland and aims to recruit 120 participants per stage. Recruitment for stage four will be conducted through community based clinical practices.ConclusionAt the conclusion of all stage, the validation of the UKP test from SAFE Analytical laboratories will be analysed. Formulation of a reference range for a healthy population range will be explored and compared to a diagnosed condition and other conditions as tested by clinicians in practice.
       
  • Therapeutic effects of saffron (Crocus sativus) versus fluoxetine on
           Irritable Bowel Syndrome: A double-blind randomized clinical trial
    • Abstract: Publication date: Available online 12 February 2019Source: Advances in Integrative MedicineAuthor(s): Borna Tadyon Najafabadi, Kiandokht Ghamari, Tahereh Kermany Ranjabari, Ahmad Ali Noorbala, Naser Ebrahimi Daryani, Elmira Vanaki, Shahin AkhondzadehAbstractBackgroundIrritable Bowel Syndrome (IBS) is an expensive and prevalent functional bowel disorder that can reduce work productivity and quality of life especially among youth. IBS is characterized by recurrent abdominal pain associated with defecation or a change in bowel habits and commonly accompanied by depression and anxiety as comorbid situations. On the other hand, saffron (Crocus sativus) is an herbal medicine with anti-depressive properties. This study aimed to compare efficacy of saffron and fluoxetine in increasing IBS patients’ quality of life.MethodsSixty-six patients with IBS, according to Rome III criteria, participated in a double-blinded parallel group randomized trial. Patients were equally divided into two groups and either received saffron or fluoxetine for 6 weeks. Every 2 weeks, each patient was requested to complete IBS quality of life and hospital anxiety and depression scale questionnaires and asked to report side effects of treatment.ResultsBaseline characteristics of groups were insignificantly different. General linear model repeated measures revealed no significant within subject effect for time × treatment interaction difference among two groups for quality of life score (p-value = 0.755), depression (p-value = 0.643) and anxiety (p-value = 0.150) scores among groups.ConclusionsOur findings demonstrated that saffron could be as effective as fluoxetine in increasing IBS patients’ quality of life with similar anti-depressive and anxiolytic effect among these patients. What might make saffron a proper medical treatment alternative for IBS is its rare side effects, wide range of use and greater patient compliance. However, further investigation and research in the area is recommended.
       
  • Survival analysis and prognostic factors of the timing of first antenatal
           care visit in Nigeria
    • Abstract: Publication date: Available online 12 February 2019Source: Advances in Integrative MedicineAuthor(s): Adeniyi Francis Fagbamigbe, Clearance Abel, Baitshephi Mashabe, Ayo Stephen AdebowaleAbstractObjectivesThis study assessed the timing of the first ANC visit among pregnant women and identified its prognostic factors.DesignData obtained from 2013 Nigerian DHS, a cross-sectional and nationally representative survey, were used.MethodsWe included women who had had at least a childbirth or got a pregnancy terminated within the five years preceding the survey or currently pregnant as of the time of the survey. The outcome variable is the timing of the first ANC visit to skilled ANC service provider. Those who were either currently pregnant or lost pregnancy but have not accessed ANC were censored. Basic descriptive statistics and survival analysis techniques involving four models were used to analyze the data at p = 0.05. Data was weighted and adjustment made for survey design and sampling errors.ResultsAlmost half of the respondents were aged 25–34 years. Only 65.5% had at least one contact with skilled ANC providers and such visits were initiated mostly (58%) in the second trimester. The overall incidence rate of accessing ANC per month is 110 per 1000 women. Women with higher education had a higher adjusted hazard of accessing ANC than uneducated women (aHR = 2.89, 95% CI: 2.68–3.11). Older women from households in richer wealth quintile are more likely to initiate ANC. Women from households in richer wealth quintiles, those who had no problem in accessing ANC facilities, those with higher education, residing in urban areas and in the Southern region had a higher tendency of earlier ANC initiation.ConclusionANC utilization in Nigeria is low and the timings of first visits are delayed. For Nigeria to achieve timely and adequate use of ANC services, health facilities should be more accessible and women should be empowered in terms of education, autonomy, and earnings in addition to changes in social-cultural practices that prevent ANC uptakes.
       
  • The effect of aromatherapy with bitter orange (Citrus aurantium) extract
           on anxiety and fatigue in type 2 diabetic patients
    • Abstract: Publication date: Available online 29 January 2019Source: Advances in Integrative MedicineAuthor(s): Fariba Abdollahi, Tofigh MobaderyAbstractObjectiveStudies have shown some complementary therapies to be effective in the management of diabetes and its comorbidities. The present study was conducted to evaluate the effect of an aromatherapy extract on anxiety and fatigue in type 2 diabetic patients.Methods60 type 2 diabetic patients were randomly assigned in two groups: patients in the intervention group received bitter orange (Citrus aurantium) extract inhalation aromatherapy for three consecutive nights before sleeping, whereas patients in the control group received usual care. Patients’ level of anxiety and fatigue was recorded before and after intervention using Visual Analog Scale (VAS).ResultsThe mean score of anxiety in patients in the intervention group before and after intervention were 63.13 ± 40.42 and 52.9 ± 3.57, respectively (P 
       
  • Investigating the validity of Muscle Response Testing: Blinding the
           patient using subliminal visual stimuli
    • Abstract: Publication date: Available online 7 June 2019Source: Advances in Integrative MedicineAuthor(s): Anne M. Jensen, Richard J. Stevens, Amanda J. BurlsAbstractResearch ObjectiveTo determine if Muscle Response Testing (MRT) can be used to distinguish lies from truths using blind test patients.DesignA prospective study of diagnostic test accuracy was carried out using MRT to distinguish lies from truth.MethodsTwenty practitioners who routinely practised MRT were paired with 20 blind test patients (TPs). TPs were asked to speak simple true and false statements about visual stimuli presented subliminally (at 20 msec). In the subliminal phase, pairs performed 20 MRTs and 20 Intuitive Guesses (IG), consisting of 2 blocks of 10 statements each. In the Supraliminal Phase, the same picture-statement pairs were repeated. The order of stimuli presentation was randomly assigned so that each pair was presented with a unique series of stimuli.ResultsIn the Subliminal Phase, MRT accuracy (as percent correct) was found to be 48.5% (95% CI 42.8 – 54.2), which was no different from IG accuracy (47.8%; 95% CI 43.2 – 52.3; p = 0.68) or chance (50.0%; p = 0.59), and no different from MRT accuracy during the supraliminal phase (59.0%; 95% CI 50.4 – 67.6; p = 0.05). However, supraliminal MRT accuracy was significantly different from chance (p = 0.04), indicating that the pairs could perform MRT proficiently.ConclusionThe main reason for finding no effect is suspected to be due to an inadequate subliminal methodology, a process which is quite complex. Other explanations of results include: (1) MRT is not a valid test when the TP is blind, (2) Blinding TPs during MRT will produce ambiguous or unpredictable results, or (3) Nonconscious beliefs cannot be elicited using subliminal stimuli. Future research may wish to focus on exploring these possibilities. More specifically, subsequent studies may wish to use different methods to blind TPs, and establish whether MRT can be used to detect nonconscious processes, a generally held consensus among MRT practitioners.
       
  • Communication about traditional complementary and alternative medicine
           (TCAM) in childhood cancer: A comparison between Dutch and Indonesian
           health-care providers at academic hospitals
    • Abstract: Publication date: Available online 9 May 2019Source: Advances in Integrative MedicineAuthor(s): Dwi Susilawati, Stefanus Gunawan, Marijn Arnoldussen, Maartje S. Gordijn, Chloe A.M. ten Broeke, Sri Mulatsih, Mei N. Sitaresmi, Gertjan J.L. Kaspers, Saskia MostertAbstractObjectivesCommunication about Traditional Complementary and Alternative Medicine (TCAM) use is important in both Western and Eastern countries to prevent interference with conventional cancer treatment. This study compares communication about TCAM of health-care providers (HCP) involved in childhood cancer care in Netherlands and Indonesia.MethodCross-sectional study at Dutch and Indonesian academic hospital using semi-structured questionnaires.ResultsOverall 342 HCP participated: 119 Dutch and 223 Indonesian HCP (response rate 80% and 87%). HCP have negative perspectives about TCAM according to more Dutch (80%) than Indonesian (42%) HCP (p 
       
  • The use of learning technologies in complementary medicine education:
           Results of a student technology survey
    • Abstract: Publication date: Available online 12 April 2019Source: Advances in Integrative MedicineAuthor(s): Alastair C. Gray, Helene Diezel, Amie Steel
       
  • Effect of omega-3 supplementation on the omega-3 blood index and fatty
           acid biomarkers in healthy individuals
    • Abstract: Publication date: Available online 12 April 2019Source: Advances in Integrative MedicineAuthor(s): Kellie Bilinski, Dennis Chang, Paul Fahey, Alan Bensoussan
       
  • Integrative Medicine for Significant Dysfunction from Tinnitus: Treatment
           Rationale and Protocol for a Randomized Clinical Pilot Trial
    • Abstract: Publication date: Available online 11 April 2019Source: Advances in Integrative MedicineAuthor(s): Ruth Q. Wolever, Rebecca J. Kane, A. Garrett Hazelton, Elizabeth M. Bechard, Debara L. TucciAbstractObjectivesFollowing the British Medical Research Council recommendations for pilot trials, this study aims to increase experience with a complex integrative medicine (IM) intervention in a randomized controlled design to assess the feasibility for studying this intervention in a larger trial. Specific objectives are to: 1) assess the feasibility of implementing this IM approach to improve dysfunction from tinnitus in a large clinical trial; 2) evaluate patient satisfaction with this complex intervention; and 3) obtain preliminary clinical efficacy data using the planned procedures and measures.Design & MethodsThis XXXX-funded pilot study targets retention of 40 participants with significant tinnitus-related dysfunction, recruited from a conventional otolaryngology clinic. To maximize experience with the intervention, enrolled participants are randomized in a 3:1 ratio to IM + a commonly applied sound-based and educational therapy (SBE) or to SBE alone. The 6-month IM treatment includes the same SBE, modeled after the Veteran’s Affairs Progressive Tinnitus Management approach, as well as 3 cognitive behavioral psychotherapy sessions, an 8-week Mindfulness Based Stress Reduction course, 5 acupuncture sessions, and 9 telephonic health coaching sessions. Enrollment, retention, patient satisfaction and lessons learned by the trial team will determine the feasibility of using this complex IM intervention in a large trial. Baseline, post-treatment, and 3-months follow-up measures and trial procedures planned for the larger trial are also piloted, with change in tinnitus-dysfunction over the intervention slated to provide preliminary clinical efficacy data.DiscussionThis pilot protocol will inform decisions regarding the feasibility of using this complex IM intervention in a large clinical trial. The larger trial would potentially offer patients an IM treatment to amplify conventional SBE for those who are unable to habituate to tinnitus.
       
  • Medical Synopsis: The Use of Vitamin E and Omega 3 fatty acids for the
           Management of Primary Dysmenorrhea
    • Abstract: Publication date: Available online 6 April 2019Source: Advances in Integrative MedicineAuthor(s): R. Reid, J. Schloss
       
  • Natural products regulation–getting the balance right. The case of
           Arbutin
    • Abstract: Publication date: Available online 6 April 2019Source: Advances in Integrative MedicineAuthor(s): Jason Rainforest, David Casteleijn, Diana Bowman, Ian Breakspear, Tobey Pinder
       
 
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