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Publisher: Elsevier   (Total: 3182 journals)

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Showing 1 - 200 of 3182 Journals sorted alphabetically
Academic Pediatrics     Hybrid Journal   (Followers: 38, SJR: 1.655, CiteScore: 2)
Academic Radiology     Hybrid Journal   (Followers: 26, SJR: 1.015, CiteScore: 2)
Accident Analysis & Prevention     Partially Free   (Followers: 102, SJR: 1.462, CiteScore: 3)
Accounting Forum     Hybrid Journal   (Followers: 28, SJR: 0.932, CiteScore: 2)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 40, SJR: 1.771, CiteScore: 3)
Achievements in the Life Sciences     Open Access   (Followers: 7)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 6)
Acta Astronautica     Hybrid Journal   (Followers: 437, SJR: 0.758, CiteScore: 2)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 2)
Acta Biomaterialia     Hybrid Journal   (Followers: 28, SJR: 1.967, CiteScore: 7)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 3)
Acta de Investigación Psicológica     Open Access   (Followers: 3)
Acta Ecologica Sinica     Open Access   (Followers: 11, SJR: 0.18, CiteScore: 1)
Acta Histochemica     Hybrid Journal   (Followers: 6, SJR: 0.661, CiteScore: 2)
Acta Materialia     Hybrid Journal   (Followers: 314, SJR: 3.263, CiteScore: 6)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.504, CiteScore: 1)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.542, CiteScore: 1)
Acta Oecologica     Hybrid Journal   (Followers: 12, SJR: 0.834, CiteScore: 2)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription  
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 2, SJR: 0.307, CiteScore: 0)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1, SJR: 1.793, CiteScore: 6)
Acta Poética     Open Access   (Followers: 4, SJR: 0.101, CiteScore: 0)
Acta Psychologica     Hybrid Journal   (Followers: 26, SJR: 1.331, CiteScore: 2)
Acta Sociológica     Open Access   (Followers: 1)
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.052, CiteScore: 2)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3, SJR: 0.374, CiteScore: 1)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.344, CiteScore: 1)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 1)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 7, SJR: 0.19, CiteScore: 0)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 3)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 8)
Acute Pain     Full-text available via subscription   (Followers: 15, SJR: 2.671, CiteScore: 5)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.53, CiteScore: 4)
Addictive Behaviors     Hybrid Journal   (Followers: 18, SJR: 1.29, CiteScore: 3)
Addictive Behaviors Reports     Open Access   (Followers: 9, SJR: 0.755, CiteScore: 2)
Additive Manufacturing     Hybrid Journal   (Followers: 11, SJR: 2.611, CiteScore: 8)
Additives for Polymers     Full-text available via subscription   (Followers: 23)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 184, SJR: 4.09, CiteScore: 13)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 12, SJR: 1.167, CiteScore: 4)
Advanced Powder Technology     Hybrid Journal   (Followers: 17, SJR: 0.694, CiteScore: 3)
Advances in Accounting     Hybrid Journal   (Followers: 9, SJR: 0.277, CiteScore: 1)
Advances in Agronomy     Full-text available via subscription   (Followers: 17, SJR: 2.384, CiteScore: 5)
Advances in Anesthesia     Full-text available via subscription   (Followers: 29, SJR: 0.126, CiteScore: 0)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 2)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 12, SJR: 0.992, CiteScore: 1)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 12, SJR: 1.551, CiteScore: 4)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 24, SJR: 2.089, CiteScore: 5)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 15, SJR: 0.572, CiteScore: 2)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.61, CiteScore: 7)
Advances in Botanical Research     Full-text available via subscription   (Followers: 2, SJR: 0.686, CiteScore: 2)
Advances in Cancer Research     Full-text available via subscription   (Followers: 34, SJR: 3.043, CiteScore: 6)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 1.453, CiteScore: 2)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 1.992, CiteScore: 5)
Advances in Cell Aging and Gerontology     Full-text available via subscription   (Followers: 5)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 14)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 29, SJR: 0.156, CiteScore: 1)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 11, SJR: 0.713, CiteScore: 1)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 10, SJR: 1.316, CiteScore: 2)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 26, SJR: 1.562, CiteScore: 3)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 20, SJR: 1.977, CiteScore: 8)
Advances in Computers     Full-text available via subscription   (Followers: 14, SJR: 0.205, CiteScore: 1)
Advances in Dermatology     Full-text available via subscription   (Followers: 15)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 13)
Advances in Digestive Medicine     Open Access   (Followers: 12)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 7)
Advances in Drug Research     Full-text available via subscription   (Followers: 26)
Advances in Ecological Research     Full-text available via subscription   (Followers: 43, SJR: 2.524, CiteScore: 4)
Advances in Engineering Software     Hybrid Journal   (Followers: 29, SJR: 1.159, CiteScore: 4)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 8)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 51, SJR: 5.39, CiteScore: 8)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 1)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 9)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 66, SJR: 0.591, CiteScore: 2)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 17)
Advances in Genetics     Full-text available via subscription   (Followers: 21, SJR: 1.354, CiteScore: 4)
Advances in Genome Biology     Full-text available via subscription   (Followers: 10, SJR: 12.74, CiteScore: 13)
Advances in Geophysics     Full-text available via subscription   (Followers: 7, SJR: 1.193, CiteScore: 3)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 26, SJR: 0.368, CiteScore: 1)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 11, SJR: 0.749, CiteScore: 3)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 25)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 3, SJR: 0.193, CiteScore: 0)
Advances in Immunology     Full-text available via subscription   (Followers: 37, SJR: 4.433, CiteScore: 6)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 10, SJR: 1.163, CiteScore: 2)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 2, SJR: 1.938, CiteScore: 3)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6, SJR: 0.176, CiteScore: 0)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 3)
Advances in Life Course Research     Hybrid Journal   (Followers: 9, SJR: 0.682, CiteScore: 2)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 8)
Advances in Marine Biology     Full-text available via subscription   (Followers: 21, SJR: 0.88, CiteScore: 2)
Advances in Mathematics     Full-text available via subscription   (Followers: 14, SJR: 3.027, CiteScore: 2)
Advances in Medical Sciences     Hybrid Journal   (Followers: 8, SJR: 0.694, CiteScore: 2)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 5, SJR: 1.158, CiteScore: 3)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 24)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 8)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.182, CiteScore: 0)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 5)
Advances in Oncobiology     Full-text available via subscription   (Followers: 2)
Advances in Organ Biology     Full-text available via subscription   (Followers: 2)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 18, SJR: 1.875, CiteScore: 4)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.174, CiteScore: 0)
Advances in Parasitology     Full-text available via subscription   (Followers: 5, SJR: 1.579, CiteScore: 4)
Advances in Pediatrics     Full-text available via subscription   (Followers: 27, SJR: 0.461, CiteScore: 1)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 19)
Advances in Pharmacology     Full-text available via subscription   (Followers: 17, SJR: 1.536, CiteScore: 3)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 0.574, CiteScore: 1)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.109, CiteScore: 1)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 10)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 6)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 19)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20, SJR: 0.791, CiteScore: 2)
Advances in Psychology     Full-text available via subscription   (Followers: 67)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 6, SJR: 0.371, CiteScore: 1)
Advances in Radiation Oncology     Open Access   (Followers: 1, SJR: 0.263, CiteScore: 1)
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.101, CiteScore: 0)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 6)
Advances in Space Research     Full-text available via subscription   (Followers: 422, SJR: 0.569, CiteScore: 2)
Advances in Structural Biology     Full-text available via subscription   (Followers: 5)
Advances in Surgery     Full-text available via subscription   (Followers: 13, SJR: 0.555, CiteScore: 2)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 37, SJR: 2.208, CiteScore: 4)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 20)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 15)
Advances in Virus Research     Full-text available via subscription   (Followers: 6, SJR: 2.262, CiteScore: 5)
Advances in Water Resources     Hybrid Journal   (Followers: 54, SJR: 1.551, CiteScore: 3)
Aeolian Research     Hybrid Journal   (Followers: 6, SJR: 1.117, CiteScore: 3)
Aerospace Science and Technology     Hybrid Journal   (Followers: 385, SJR: 0.796, CiteScore: 3)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.42, CiteScore: 2)
African J. of Emergency Medicine     Open Access   (Followers: 6, SJR: 0.296, CiteScore: 0)
Ageing Research Reviews     Hybrid Journal   (Followers: 12, SJR: 3.671, CiteScore: 9)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 477, SJR: 1.238, CiteScore: 3)
Agri Gene     Hybrid Journal   (Followers: 1, SJR: 0.13, CiteScore: 0)
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 18, SJR: 1.818, CiteScore: 5)
Agricultural Systems     Hybrid Journal   (Followers: 31, SJR: 1.156, CiteScore: 4)
Agricultural Water Management     Hybrid Journal   (Followers: 44, SJR: 1.272, CiteScore: 3)
Agriculture and Agricultural Science Procedia     Open Access   (Followers: 4)
Agriculture and Natural Resources     Open Access   (Followers: 3)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 58, SJR: 1.747, CiteScore: 4)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.589, CiteScore: 3)
Air Medical J.     Hybrid Journal   (Followers: 8, SJR: 0.26, CiteScore: 0)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.19, CiteScore: 0)
Alcohol     Hybrid Journal   (Followers: 12, SJR: 1.153, CiteScore: 3)
Alcoholism and Drug Addiction     Open Access   (Followers: 12)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 2, SJR: 0.604, CiteScore: 3)
Alexandria J. of Medicine     Open Access   (Followers: 1, SJR: 0.191, CiteScore: 1)
Algal Research     Partially Free   (Followers: 11, SJR: 1.142, CiteScore: 4)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.504, CiteScore: 1)
Allergology Intl.     Open Access   (Followers: 5, SJR: 1.148, CiteScore: 2)
Alpha Omegan     Full-text available via subscription   (SJR: 3.521, CiteScore: 6)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 10, SJR: 0.201, CiteScore: 1)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 53, SJR: 4.66, CiteScore: 10)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 6, SJR: 1.796, CiteScore: 4)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 6, SJR: 1.108, CiteScore: 3)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 5)
American Heart J.     Hybrid Journal   (Followers: 58, SJR: 3.267, CiteScore: 4)
American J. of Cardiology     Hybrid Journal   (Followers: 63, SJR: 1.93, CiteScore: 3)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 46, SJR: 0.604, CiteScore: 1)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 12)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.524, CiteScore: 3)
American J. of Human Genetics     Hybrid Journal   (Followers: 37, SJR: 7.45, CiteScore: 8)
American J. of Infection Control     Hybrid Journal   (Followers: 29, SJR: 1.062, CiteScore: 2)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 36, SJR: 2.973, CiteScore: 4)
American J. of Medicine     Hybrid Journal   (Followers: 50)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3, SJR: 1.967, CiteScore: 2)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 255, SJR: 2.7, CiteScore: 4)
American J. of Ophthalmology     Hybrid Journal   (Followers: 66, SJR: 3.184, CiteScore: 4)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 5, SJR: 0.265, CiteScore: 0)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.289, CiteScore: 1)
American J. of Otolaryngology     Hybrid Journal   (Followers: 25, SJR: 0.59, CiteScore: 1)
American J. of Pathology     Hybrid Journal   (Followers: 33, SJR: 2.139, CiteScore: 4)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 28, SJR: 2.164, CiteScore: 4)
American J. of Surgery     Hybrid Journal   (Followers: 39, SJR: 1.141, CiteScore: 2)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.767, CiteScore: 1)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 7)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.144, CiteScore: 3)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 66, SJR: 0.138, CiteScore: 0)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 24, SJR: 0.411, CiteScore: 1)
Anales de Cirugia Vascular     Full-text available via subscription   (Followers: 1)
Anales de Pediatría     Full-text available via subscription   (Followers: 3, SJR: 0.277, CiteScore: 0)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription  
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 5, SJR: 4.849, CiteScore: 10)
Analytica Chimica Acta     Hybrid Journal   (Followers: 44, SJR: 1.512, CiteScore: 5)
Analytica Chimica Acta : X     Open Access  
Analytical Biochemistry     Hybrid Journal   (Followers: 209, SJR: 0.633, CiteScore: 2)
Analytical Chemistry Research     Open Access   (Followers: 13, SJR: 0.411, CiteScore: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 14)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 2)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 25, SJR: 0.683, CiteScore: 2)
Angiología     Full-text available via subscription   (SJR: 0.121, CiteScore: 0)
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1, SJR: 0.111, CiteScore: 0)
Animal Behaviour     Hybrid Journal   (Followers: 224, SJR: 1.58, CiteScore: 3)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 6, SJR: 0.937, CiteScore: 2)
Animal Reproduction Science     Hybrid Journal   (Followers: 7, SJR: 0.704, CiteScore: 2)

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Similar Journals
Journal Cover
Indian Heart Journal
Journal Prestige (SJR): 0.333
Citation Impact (citeScore): 1
Number of Followers: 5  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0019-4832
Published by Elsevier Homepage  [3182 journals]
  • Evaluation Of Intra-Coronary Blood From Obstructive Vessel In Patients Of
           St-Elevation Myocardial Infarction Undergoing Primary Pci

    • Abstract: Publication date: Available online 26 September 2019Source: Indian Heart JournalAuthor(s): Suraj Kumar, Gurpreet S. Wander, Bhupinder Singh, Maninder Kansal, Bishav Mohan, Naved Aslam, Shibba T. Chabbra, Abhishek Goyal, Sumit Kumar ObjectiveInformation available on acid-base imbalance in ST-elevation myocardial infarction submitted to primary percutaneous intervention is limited and no data was present on intracoronary blood analysis, extracted from obstructed artery.MethodsThis was a prospective study conducted over 12 months in which STEMI patients presenting in emergency and undergoing Primary PCI were included. Blood gas analysis of intracoronary arterial blood from obstructed vessel and peripheral arterial blood was done. Patients in whom adequateintracoronary sample could not be obtained were excluded. Intracoronary and peripheral arterial blood gas measurements were correlated and relationship of Intracoronary parameters were compared clinical parameters, investigational markers and short-term outcome.ResultsThe mean age of study population was 54.8 years andaverage symptom onset to door time was 162 mins. On comparing intracoronary blood to peripheral blood arterial obtained, pH (95%CI-0.01-0.02;p=0.44), lactate (95%CI 0.03-0.1;p=0.28), bicarbonate (95%CI 0.6-1.5;p=0.64), pCO2(95%CI 1.1-2.4;p=0.79) and pO2(95%CI 3.2-47.5; p=0.06), were all found to be statistically insignificant. Intracoronary hyperlactemia was present in patients presenting with higher symptom onset to door time(p=0.025). SBP(p=0.03)was also significantly lower in patients who had high intracoronary lactate levels.ConclusionThe evaluation of intracoronary blood provides no additional information regarding the prognosis and short-term (30-days) outcome of the patients when compared to peripheral blood. However, there was significant intracoronary hyperlactemia in patients presenting late after symptom onset. SBP was also significantly less in patients with high intracoronary lactate, which signifies that predominant cause of hyperlactemia was systemic hypoperfusion rather than local increase in lactate levels.
       
  • Thrombolysis with Reteplase in Acute Pulmonary Embolism

    • Abstract: Publication date: Available online 20 September 2019Source: Indian Heart JournalAuthor(s): K.R. Nishanth, Math Ravi S, Shankar Mythri, K.S. Ravindranath, C.N. Manjunath ObjectiveReteplase (recombinant plasminogen activator) is a mutant of alteplase. It has a longer half-life than its parent molecule and has shown better vessel patency rates in acute myocardial infarction. In this study, we analyzed the efficacy and safety of reteplase in acute pulmonary embolism (PE).MethodsThis observational study included patients with high and intermediate risk acute PE, presenting within 14 days of symptom onset. Patients were treated with reteplase given in two bolus doses of 10 U each, 30 minutes apart, along with intravenous heparin. Patients with hemodynamic compromise (high risk or massive PE) and normotensive patients with evidence of right ventricular (RV) dysfunction (intermediate risk or submassive PE) on echocardiography or computed tomography were included in the study. The efficacy outcomes assessed were in hospital death and improvement of RV function by echocardiography. The safety outcomes were major, minor bleeding and ischemic or hemorrhagic stroke during hospitalization.ResultsOf 40 patients included, 25% were high risk with hemodynamic compromise and 75% were intermediate risk. RV dysfunction was present in all (100%) the patients. Concomitant lower extremity deep vein thrombosis was present in 55% of the patients. The mortality rate was 5%. There was significant improvement in RV function, reduction in pulmonary artery systolic pressure and tricuspid regurgitation severity. There was no major bleeding event or stroke and 7.5% had minor extracranial bleeding.ConclusionsDouble bolus reteplase given with heparin is effective in the treatment of high, intermediate risk pulmonary embolism with minimal risk of bleeding.
       
  • Permanent His-bundle pacing feasibility in routine clinical practice:
           experience from Indian centre

    • Abstract: Publication date: Available online 18 September 2019Source: Indian Heart JournalAuthor(s): Rakesh Sarkar, Daljeet Kaur, Muthiah Subramanian, Sachin Yalagudri, C. Sridevi, Soumen Devidutta, Debabrata Bera, Calambur Narasimhan There is a paucity of experience regarding His-bundle pacing (HBP) at labs initially attempting the procedure, especially in the Indian scenario. Patient underwent HBP were either selected for pacing therapy or in lieu of CRT at a single center. Among 22 patients attempted, 19 patients underwent successful implant achieving selective HBP in 14. There was a significant improvement of LVEF(49.3±9.3 vs. 36.7 ± 9.2) in the LV dysfunction subgroup(n=6). Over a follow up of 15±6.5 months, thresholds were stable in all except one patient and there was no requirement of lead revision. In summary, we found that HBP is a feasible option for achieving physiological pacing.
       
  • Prevalence of Hypertension among Indian Adults: Results from the Great
           India Blood Pressure Survey

    • Abstract: Publication date: Available online 18 September 2019Source: Indian Heart JournalAuthor(s): Sivasubramanian Ramakrishnan, Geevar Zachariah, Kartik Gupta, J. Shivkumar Rao, P.P. Mohanan, K. Venugopal, Santosh Sateesh, Rishi Sethi, Dharmendra Jain, Neil Bardolei, Kalaivani Mani, Tanya Singh Kakar, Bharathraj Kidambi, Sudha Bhushan, Sunil K. Verma, Balram Bhargava, Ambuj Roy, Shyam S. Kothari, Rajeev Gupta, Sandeep Bansal ObjectiveHypertension is the most important risk factor for cardiovascular morbidity and mortality. There is limited data on hypertension prevalence in India. This study was conducted to estimate the prevalence of hypertension among Indian adults.MethodsA national level survey was conducted with fixed one-day blood pressure measurement camps across 24 states and union territories of India. Hypertension was defined as systolic blood pressure (BP) ≥140 mmHg or a diastolic BP ≥90 mmHg or on treatment. The prevalence was age and gender-standardized according to the 2011 census population of India.ResultsBlood pressure was recorded for a total of 180,335 subjects (33.2% women; mean age 40.6 ± 14.9 years). Among them 8898 (4.9%), 99791 (55.3%), 35694 (11.9%), 23084 (12.8%), 9989 (5.5%) and 2878 (1.6%) subjects were of the age group 18-19, 20-44, 45-54, 55-64, 65-74 and ≥75 years respectively. Overall prevalence of hypertension was 30.7% (95% confidence interval [CI] 30.5, 30.9) and the prevalence among women was 23.7% (95% CI 23.3, 24). Prevalence adjusted for 2011 census population and the WHO reference population was 29.7% and 32.8%, respectively.ConclusionThere is a high prevalence of hypertension, with almost one in every three Indian-adult affected.
       
  • Incidence and Predictors of Super-response to Cardiac Resynchronization
           Therapy

    • Abstract: Publication date: Available online 9 September 2019Source: Indian Heart JournalAuthor(s): ManojKumar Rohit, Darshan Krishnappa ObjectivesCardiac re-synchronization therapy (CRT) has significantly improved management of patients with HFrEF. A significant number of patients have a dramatic response and have been termed ‘super-responders’. The characteristics of this subset of patients in Indian and Asian population have not been well studied. In this study we sought to assess the prevalence and clinical characteristics of this cohort of patients.MethodsThis was a retrospective study involving patients undergoing CRT. Changes in ejection fraction and LVESV at the end of one year of follow-up following device implantation were assessed and patients stratified into non-responders, responders and super-responders. Responders had a 15 – 29% decrease in LVESV while super-responders had a>30% decrease in LVESV.ResultsOf the 74 patients who had undergone CRT-P/CRT-D implantation, 16 patients did not have echocardiograms at the end of one year of follow-up and were excluded from the analysis. Thus, 58 patients were enrolled for analysis. We identified 16 patients(27.6%) to be super-responders, 26 patients(44.8%) to be responders and 16 patients(27.6%) to be non-responders. Factors associated with a super-response were, a diagnosis of dilated cardiomyopathy as against ischemic cardiomyopathy(93.7% vs 6.3%; p – 0.01), prior RV apical pacing(25% vs 2.4%; p – 0.02) and absence of a prior history of myocardial infarction(MI)(0% vs 33.3%; p – 0.02).ConclusionIn our study, 27.6% of patients were super-responders and dilated cardiomyopathy, absence of a prior history of MI and prior RV apical pacing tended to predict a super-response to CRT.
       
  • Cardiovascular manifestations of people living with HIV/AIDS: Report from
           a hot spot in eastern india

    • Abstract: Publication date: Available online 9 September 2019Source: Indian Heart JournalAuthor(s): D.R. Trinath Kumar Mishra, D.R. Sura Kishor Mishra, D.R. Subhasish Singh ObjectiveTo study the profile and characteristics of cardiovascular abnormalities among patients living with HIV/AIDS at a tertiary care hospital in India. The association of cardiovascular abnormalities with the CD4 count and disease stages, according to the World Health Organization (WHO) classification, was also analyzed.MethodsA total of 200 patients with HIV/AIDS were compared with 50 healthy controls. All patients underwent blood investigations, chest X-ray, electrocardiography, and echocardiography.ResultsThe mean age of the patients was 38.66 ± 9.22 years, with a male-to-female ratio of 3.25:1. Echocardiographic abnormalities were found in 52% of the patients and 12% of the controls, with the most common abnormality being left ventricular diastolic dysfunction. Echocardiographic abnormalities were markedly more common in patients with a CD4 count of
       
  • CHA2DS2-VASc Score as a novel predictor for Contrast-Induced Nephropathy
           after Percutaneous Coronary Intervention in Acute Coronary Syndrome

    • Abstract: Publication date: Available online 9 September 2019Source: Indian Heart JournalAuthor(s): Abhay Kumar Chaudhary, Vijay Pathak, Shekhar Kunal, Shubhra Shukla, Pooja Pathak ObjectiveCHA2DS2-VASc score, used for atrial fibrillation to assess the risk of embolic complications, have shown to predict adverse clinical outcomes in acute coronary syndrome (ACS), irrespective of atrial fibrillation. This study envisaged to assess the predictive role of CHA2DS2-VASc score for contrast induced nephropathy (CIN) in ACS patients undergoing percutaneous coronary intervention(PCI).MethodTotal 300 consecutive patients of ACS undergoing PCI were enrolled in this study. CHA2DS2-VASc score was calculated for each patient. These patients were divided into two groups as Group 1(with CIN) and Group 2(without CIN).CIN was defined as increase in serum creatinine level ≥0.5 mg/dL or ≥25% increase from baseline within 48 hours after PCI. Post Receiver operating characteristic (ROC) curve analysis, the study population was again classified into two groups: CHA2DS2-VASc score ≤3 group (Group A) and score≥4 group (Group B).ResultsCIN was reported in 41 subjects(13.6%). Patients with CIN had a higher frequency of hypertension, diabetes mellitus and had a lower left ventricular ejection fraction and baseline estimated glomerular filtration rate. ROC curve analysis showed good predictive value of CHA2DS2-VASc score for CIN(AUC 0.81, 95% CI 0.73-0.90). Patients with a CHA2DS2-VASc score of ≥4 had a higher frequency of CIN as compared to patients with score ≤3 (56.8% vs 4.8%; P=0.0001) with multivariate analysis demonstrating CHA2DS2-VASc score of ≥4 to be an independent predictor of CIN.ConclusionIn patients with ACS undergoing PCI, CHA2DS2-VASc score can be used as a novel, simple and a sensitive diagnostic tool for the prediction of CIN.
       
  • Prognostic Value of Frontal QRS-T Angle in Predicting Survival After
           Primary Percutaneous Coronary Revascularization/Coronary Artery Bypass
           Grafting for ST Elevation Myocardial Infarction

    • Abstract: Publication date: Available online 9 September 2019Source: Indian Heart JournalAuthor(s): Abhishek C. Sawant, Aishwarya Bhardwaj, Shantanu Srivatsa, Srilekha Sridhara, Meghana Prakash Hiriyur Prakash, Nidhi Kanwar, Janelle Rodriguez, Gary Tse, Tong Liu, Arnav Kumar, Hiroko Beck, Sanjay S. Srivatsa BackgroundFrontal QRST Angle (FQRST) has previously been correlated with mortality in patients with stable coronary artery disease, but its role as survival predictor following STEMI remains unknown.MethodsWe evaluated 267 consecutive patients with STEMI undergoing reperfusion or coronary artery bypass grafting. Data assessed included demographics, clinical presentation, electrocardiograms, medical therapy and one-year mortality.ResultsOut of 267 patients, 187 (70%) were males and the majority (49.4%) of patients were Caucasian. All-cause mortality was significantly higher among patients with the highest (101-180°) FQRST [28% vs. 15%, p = 0.02]. Patients with FQRST 1-50° had higher survival (85.6%) compared with FQRST=51-100° (72.3%) and FQRST=101-180° (67.9%), [log rank, p=0.01]. Adjusting for significant variables identified during univariate analysis, FQRST (OR = 2.04 [95% CI: 1.31-13.50]) remained an independent predictor of one-year mortality. FQRST based risk score (1-50°=0 points, 51-100°=2 points, 101-180°=5 points) had excellent discriminatory ability for one-year mortality when combined with Mayo Clinic Risk Score [MCRS] (C statistic=0.875 [95%CI: 0.813-0.937]. A high (>4 points) FQRST risk score was associated with greater mortality (32% vs. 19%, p = 0.02) and longer length of stay (6 vs. 2 days, p < 0.001).ConclusionFQRST represents a novel independent predictor of one-year mortality in STEMI patients undergoing reperfusion. A high FQRST based risk score was associated with greater mortality and longer length of stay and, after combining with MCRS, improved discriminatory ability for one-year mortality.
       
  • Therapeutic Experience of Ticagrelor in Indian Patients with Acute
           

    • Abstract: Publication date: Available online 30 August 2019Source: Indian Heart JournalAuthor(s): J.P.S. Sawhney, J. Dalal, Mullasari A, S. Bansal, D. Kahali ObjectiveThis observational study was designed to understand the usage pattern of ticagrelor in real-life clinical practice among a large number of acute coronary disease (ACS) patients undergoing percutaneous coronary intervention (PCI), coronary artery bypass graft (CABG) or medical management (MM). The study also recorded clinical events, i.e., bleeding, dyspnea, and cardiovascular (CV) events reported by the investigator during the follow-up period.MethodsThe ACS patients of ≥18 years hospitalized for ACS and were prescribed ticagrelor upon discharge or ≤1 month and patients who underwent PCI, CABG or MM for ACS, were enrolled. The subjects were followed up for a period of up to 12 months. The data was collected on a case report form.ResultThe study recruited 2997 subjects from 49 sites in India. Approximately half of the ACS subjects had ST segment elevation myocardial infarction (STEMI) (48.9%), and PCI was used as management in 92.4% subjects. The mean (±SD) duration of use of ticagrelor was 314 (±110.2) days over a period of 12 months. Of 136 subjects (4.5%) who experienced any clinical events, CV deaths were reported in 20 (0.7%), myocardial infraction (MI) in 19 (0.6) subjects and ischemic stroke (IS) in 23 (0.8%) subjects, and severe dyspnea was reported in 68 (2.2%) subjects. Out of 33 bleeding cases, 25 (0.8%) subjects had thrombolysis in myocardial infarction (TIMI) minimal, seven (0.2%) had TIMI minor, and one TIMI major. Platelet inhibition and patient outcomes (PLATO) major was reported in two subjects and CABG bleed in one subject. The incidence of PLATO defined major & minimal bleeding were lower in subjects undergoing fibrinolysis than overall population.ConclusionTicagrelor has been used across ACS types and in different management strategies in real world settings in India. The incidence of clinical events was lower as compared to data in literature. ClinicalTrials.gov Identifier: NCT02408224
       
  • ASCVD risk score - Are indians underestimating the risk of cardiovascular
           disease'

    • Abstract: Publication date: Available online 30 August 2019Source: Indian Heart JournalAuthor(s): Ashish Kumar U, Mariam Shariff
       
  • Isolated Diastolic Hypertension and its risk factors in Semi-rural
           Population of South India

    • Abstract: Publication date: Available online 7 August 2019Source: Indian Heart JournalAuthor(s): Chetan Mittal, Mandeep Singh, Tanvir Bakhshi, S. Ram Babu, S. Rajagopal, C. Venkata S. Ram BackgroundIsolated Diastolic Hypertension (IDH) has been actively discussed for the last two decades due to its prevalence in a younger population and its association with cardiovascular disease. Further, the association of IDH is significant in South Asian Countries like India because relatively younger populations are known to have a higher risk of cardiovascular events.ObjectiveTo find prevalence of IDH and its risk correlates in asemi-urban population of South Indian state of Andhra Pradesh.MethodsData was collected using modified WHO STEPS questionnaire for 16,636 individuals from a group of villages under Thavanampalle Mandal. Collated data was analyzed for prevalence and risk factorsof IDH.ResultsPrevalence of IDH was found to be 4.0% with mean age of 46.0 (±SD 13.6) years and a relatively higher prevalence in men (5.3%) as compared to women (3.2%). The prevalence of IDH peaked in the fifth decade of life (40-49 years of age) and declined thereafter. Among various risk factors that were analyzed for their association with IDH, only age, body weight and body mass index retained their significance in multivariate binary logistic regression analysis.ConclusionThere is a significant prevalence of IDH below 50 years of age in the semi-urban population of South India. As IDH in young and middle age is known to be associated with increased risk of cardiovascular events and end organ involvement, it highlights need for study and development of effective IDH management strategies to reduce associated morbidity and mortality.
       
  • A Milestone In Prediction Of The Coronary Artery Dimensions From Multiple
           Linear Regression Equation

    • Abstract: Publication date: Available online 6 August 2019Source: Indian Heart JournalAuthor(s): A. Divia Paul, S.M. Ashraf., J. Ezhilan, S. Vijayakumar, Anuj Kapadiya IntroductionCoronary artery imaging is one of the most commonly used diagnostic methods. We aimed to investigate whether there is a correlation between left main coronary artery (LMCA), left anterior descending artery (LAD) and left circumflex artery (LCx) artery dimensions in normal cases and a possibility to express the coronary dimensions by multiple linear equations.Materials and MethodsImages of coronary angiograms of 925 normal cases selected from 3855 cases made up the study population (515 men and 410 women; age range, 30–75 years). Mean age of the patients was 55.50 ± 6.49 years. Mean body mass index (BMI) was 24.79 ± 1.45 kg/m2 (range 31.30–21.26 kg/m2). The mean dimensions of LMCA, LAD, and LCx were found as 4.18 ± 0.65 mm, 3.22 ± 0.63 mm, and 3.07 ± 0.65 mm, respectively. Correlation between LMCA, LAD and LCx diameters was investigated. Multiple linear regression analysis was used to develop a model to elucidate the relationship between LMCA, LAD and LCx diameters.ResultsThere was a strong correlation between LMCA dimensions and LAD and LCx dimensions (r=0.526**, p
       
  • The Saturated Fat Controversy: finding Calmness in Chaos

    • Abstract: Publication date: Available online 1 August 2019Source: Indian Heart JournalAuthor(s): Mohit D. Gupta, Girish MP., Rakesh Yadav
       
  • The genes polymorphism of angiotensin-converting enzyme (ACE) I/D and ACE
           G2350A in patients with left ventricular hypertrophy: a meta-analysis

    • Abstract: Publication date: Available online 6 July 2019Source: Indian Heart JournalAuthor(s): Jonny Karunia Fajar, Budi Susetio Pikir, Erdo Puncak Sidarta, Putu Nina Berlinda Saka, Rizal Rahmanda Akbar, Teuku Heriansyah ObjectivesTo evaluate the correlation between left ventricular hypertrophy and the genes polymorphism of ACE I/D and ACE G2350A.MethodsInformation related to sample size and genotypes frequencies were extracted from each study.ResultsOur results found that D allele (p = 0.0180) and DD genotype (p = 0.0110) of ACE I/D had a significant association with increasing the risk of left ventricular hypertrophy. While, I allele (p = 0.0180), but not II (p = 0.1660) and ID genotypes (p = 0.1430), were associated with decreasing the risk of left ventricular hypertrophy. On other hand, we found that A allele (p = 0.0020) and GA genotype of ACE G2350A (p = 0.0070) had the correlation with increasing the risk of left ventricular hypertrophy.ConclusionsOur meta-analysis reveals that D allele of ACE I/D and A allele of ACE G2350A are associated with increasing the risk for left ventricular hypertrophy.
       
  • Trial sequential analysis of studies Comparing the Frequency of
           Target-Vessel Revascularization with Drug-Coated Balloons as compared to
           Second-Generation Drug-Eluting Stents in Coronary In-Stent Restenosis.
           Have we generated enough evidence in the field'

    • Abstract: Publication date: Available online 12 June 2019Source: Indian Heart JournalAuthor(s): U. Ashish Kumar, Mariam Shariff
       
  • Clinical Significance of Bendopnea in Heart Failure – Systematic
           Review and Meta-analysis

    • Abstract: Publication date: Available online 3 June 2019Source: Indian Heart JournalAuthor(s): Raymond Pranata, Emir Yonas, Veresa Chintya, Amir Aziz Alkatiri, Bambang Budi Siswanto BackgroundBendopnea is a symptom mediated by increased ventricular filling pressure during bending forward. Presence of bendopnea in the patients can be easily evaluated without additional maneuver in several countries whose norms, habits, culture and occupation relates to a higher frequency of bending forward. This information may prove valuable in routine clinical practice. We aimed to analyze the latest evidence on bendopnea in order to further define the clinical significance of this symptom.MethodsWe performed a comprehensive search on bendopnea in heart failure from inception up until January 2019 through PubMed, EuropePMC, EBSCOhost, Cochrane Central Database, ClinicalTrials.gov.ResultsThere were 283 patients (31.76%) who have bendopnea and a total of 891 patients from six studiesincluded. Bendopnea was associated with the presence of dyspnea (OR 69.70 [17.35 – 280.07];
       
  • Atherogenic index of plasma and its association with cardiovascular
           disease risk factors among postmenopausal rural women of Bangladesh

    • Abstract: Publication date: Available online 3 May 2019Source: Indian Heart JournalAuthor(s): Lingkan Barua, Mithila Faruque, Palash Chandra Banik, Liaquat Ali ObjectivesThere is absolute lacking of evidences on atherogenic index of plasma (AIP) and its association with cardiovascular disease (CVD) risk factors among postmenopausal women of Bangladesh. This prompted us to investigate this association between AIP and CVD risk factors among postmenopausal women in a rural setting.MethodsThis cross-sectional study recruited 265 postmenopausal women of 40 to 70 years old who visited a primary health care centre of Bangladesh. We used modified STEP-wise approach for Surveillance of Noncommunicable diseases risk factors questionnaire of World Health Organization to collect data on sociodemographic and behavioral risk factors. Physical measurements were carried out following the method described in “Noncommunicable disease risk factors survey Bangladesh 2010”. AIP was determined by the logarithmic transformation of triglyceride (TG) to high density lipoprotein (HDL-C) ratio and association with CVD risk factors were examined by multiple linear regression analysis.ResultsOverall 35.5% respondents had a high risk level of AIP with a mean of 0.16 ± 0.25. After adjusting the confounders, CVD risk factors including duration of menopause (β = 0.606, p = 0.043), waist-hip ratio (β = 0.165, p = 0.003), 2-h plasma glucose (β = 0.118, p = 0.04), total cholesterol (β = 1.082, p < 0.001), low density lipoprotein cholesterol (β = -1.044, p < 0.001) and metabolic equivalent of tasks (β = -0.171, p = 0.003) showed a significant association with AIP.ConclusionHigh AIP and its significant association with CVD risk factors demand proper lifestyle intervention for postmenopausal women of Bangladesh.
       
  • Incidence and predictors of forearm hematoma during transradial approach
           for percutaneous coronary interventions

    • Abstract: Publication date: Available online 3 May 2019Source: Indian Heart JournalAuthor(s): Naveen Garg, Koneru Lakshmi Umamaheswar, Aditya Kapoor, Satendra Tewari, Roopali Khanna, Sudeep Kumar, Pravin Kumar Goel BackgroundTransradial approach for percutaneous coronary intervention (TRA-PCI) reduces vascular complications compared to transfemoral approach (TFA). Hematoma formation even though less frequent than TFA, but is not uncommon and presentation ranges from mild hematoma to compartment syndrome. Incidence and predictors of hematoma have not been well studied.Methods and ResultsPresent study was done to prospectively evaluate the incidence and predictors of forearm hematoma after TRA-PCI. Study population consisted of consecutive patients undergoing TRA-PCI. Baseline & procedural characteristics and clinical outcomes were prospectively collected. All patients were observed for forearm/arm hematoma immediately post procedure, after band removal, pre-discharge and whenever patient complained of pain/swelling in the limb. Logistic regression analysis was performed to determine the predictors for hematoma formation. Total 520 patients who had successfully completed the TRA-PCI were included in the final analysis. The mean age was 55.2 ± 9.5 years and 24% were female. Hematoma occurred in 53 (10.2%) patients. Hematomas were of grade I, II, III, and IV in 22 (4.2%), 9 (1.7%), 18 (3.5%), 4 (0.8%) patients respectively. On multivariate logistic regression analysis; age, body mass index, multiple puncture attempt, glycoprotein IIb/IIIa receptor blocker use, non-clopidogrel agent use for dual antiplatelet therapy and multiple catheter exchange emerged as independent predictors for hematoma formation.ConclusionsForearm hematoma following TRA-PCI occurs in about 10% patients. Majority occur near puncture area. Independent predictors for hematoma formation are age, body mass index, multiple puncture attempt, intensive antiplatelet therapy and multiple catheter exchanges.
       
  • Early thrombolysis is associated with decreased operative mortality in
           post infarction ventricular septal rupture

    • Abstract: Publication date: Available online 3 May 2019Source: Indian Heart JournalAuthor(s): Neeti Dogra, Goverdhan Dutt Puri, Shyam KS. Thingnam, V.K. Arya, Bhupesh Kumar, Sachin Mahajan, Madhur Verma
       
  • Cardiac Resynchronization Therapy in Patients with Heart Failure and
           Moderately Reduced Ejection Fraction; could it Trigger a
           Super-response'

    • Abstract: Publication date: Available online 3 May 2019Source: Indian Heart JournalAuthor(s): Mazen Tawfik, Lamyaa Allam, Rania Samir BackgroundDespite the well-established benefits of CRT in HF patients with LVEF ≤35%, yet many patients with less reduced EF remain refractory to optimized medical treatment and at high risk of morbidity and mortality.Objectiveto evaluate the effects of CRT in optimally treated patients with NYHA Classes II–IV, LVEF of 36–45%, and LBBB, including clinical, structural and biochemical response.MethodsThe selected group of HF patients have been implanted CRT-P devices and were followed up for 6 months at 4, 12 and 24 weeks. Clinical assessment included NYHA class, Quality of life and 6 MWD. Echocardiographic assessment included LV dimensions, function and LA volume. Serum N-terminal pro-BNP was measured at the same intervals.Resultsthis prospective single center study included 23 patients. NYHA functional class significantly improved after CRT-P (p
       
  • Genetic variants of chromosome 9p21.3 region associated with CAD and
           Premature CAD in an Asian Indian population

    • Abstract: Publication date: Available online 2 May 2019Source: Indian Heart JournalAuthor(s): Bellary Kalpana, Dwarkanath K. Murthy, N. Balakrishna, Mohini T. Aiyengar IntroductionAsian Indians have a propensity for premature, severe and diffuse Coronary Artery Disease (CAD). Several SNPs in the ‘core CAD’ region of chromosomal region 9p21.3 are known to be strongly associated with CAD.ObjectivesWe aimed to study SNPs in 9p21.3 region associated with CAD, premature CAD and identify their association with demographic and clinical characteristics in an Asian Indian population.MethodsSNP genotyping was done for 30 SNPs of 9p21.3 region using MassARRAY® technology. Along with demographic and SNP data analysis, we also performed Multivariate Logistic Regression (MLR) analysis and Multifactor Dimensionality Reduction (MDR) analysis to study SNP-SNP, SNP-demographic/clinical variable interactions.ResultsOur results suggest that females are at a higher risk of premature CAD. We found that SNPs rs1333045 (CC), rs16905599 (AA), rs2383206 (GG), rs2383208 (AG), rs4977574 (GG) were significantly associated with premature CAD. When adjusted for covariates/confounders, we found that rs2383206 showed the strongest risk association with CAD followed by rs16905599 and rs2383208. Further, SNPs rs1333049 (CC) and rs4977574 (GG) were found to be exclusively associated with premature CAD cases, suggesting their potential as genetic markers for premature CAD in the local population. Upon gender based stratification, it was found that rs10757272 (TT & TC) is significantly associated with 8-9 fold CAD risk specifically among females. SNP rs7865618 (GG) is significantly associated with more than 2.5 fold CAD risk specifically among males.ConclusionOur study suggests that SNPs at 9p21 risk locus may be used to generate a reliable Genetic Risk Score along with markers at other loci.
       
  • Lipoprotein(a): An Under recognized Genetic Risk Factor for Malignant
           Coronary Artery Disease in Young Indians

    • Abstract: Publication date: Available online 2 May 2019Source: Indian Heart JournalAuthor(s): Enas A. Enas, Basil Varkey, T.S. Dharmarajan, Guillaume Pare, Vinay K. Bahl Malignant coronary artery disease (CAD) refers to a severe and extensive atherosclerotic process involving multiple coronary arteries in young individuals (
       
  • Comparison Of Three Dimensional Echocardiography And Speckle Tracking
           Echocardiography In Quantification And Mapping Of Intra-Ventricular
           Mechanical Dyssynchrony

    • Abstract: Publication date: Available online 2 May 2019Source: Indian Heart JournalAuthor(s): Anupam Bhambhani, Amalu Mathew ObjectivesTo compare two advanced methods of evaluation of left ventricular mechanical dyssynchrony (LVMD), the speckle tracking echocardiography (STE) and the three dimensional echocardiography (3DE).Methods136 subjects, with or without LV dysfunction and with or without bundle branch block (BBB) were included in this study, designed to investigate agreement between magnitude and spatial pattern of LVMD as assessed by 3DE and STE. The frequency and severity of LVMD and localization of most asynchronous segment were compared.ResultsBoth 3DE and STE revealed progressive rise in frequency as well as magnitude of LVMD with increasing disease severity. Dyssynchrony was dependent on LVEF rather than QRS duration. The frequency and magnitude of dyssynchrony were maximum in patients having LV dysfunction with LBBB. Compared to STE, 3DE diagnosed LVMD more frequently in patients having LV dysfunction with narrow QRS (17.6% vs 60.3% respectively; P
       
  • Impairment of Left and Right Ventricular Longitudinal Strain in
           Asymptomatic Children with Type 1 Diabetes

    • Abstract: Publication date: Available online 2 May 2019Source: Indian Heart JournalAuthor(s): Ihsen Zairi, Khadija Mzoughi, Sofien Kamoun, Fethia Ben Moussa, Rabie Rezgallah, Sonia Mazigh, Sondos Kraiem AimThe relationship between type 1 diabetes (T1DM) and cardiac function in children is not well established. The purpose of this study was to investigate whether children and adolescents with T1DM present early asymptomatic abnormalities of left ventricular (LV)and right ventricular (RV) function. In addition, we evaluated the relationship of any such abnormalities with glycemic control and diabetes duration.MethodsThis was a prospective study. Standard echocardiography, tissue Doppler imaging, and two-dimensional strain analysis were performed prospectively in 52 children with T1DM. The results were compared with those from 52 healthy children matched for age and sex.ResultsThere were no significant differences between the two groups in LV ejection fraction or RV systolic function. There was a difference between the two study groups in transtricuspid flow: the E-wave and A-wave velocities were significantly higher in the diabetic group. Left ventricular Global longitudinal strain(LV GLS) was significantly lower in T1DM children (−20.01 ± 1.86% vs. −22.99 ± 0.98%, respectively; P < .001), as was RV free-wall longitudinal starin (RV FWLS) (−29.13 ± 1.85% vs. −30.22 ± 1.53%, respectively; P = .002). LV GLS was correlated with diabetes duration (r = 0.444, P < .001) and hemoglobin (HbA1c) (r = 0.683, P < .001); however, no correlation was found between RV FWLS and HbA1c or diabetes durationConclusionsOur findings suggest that LV GLS and RV FWLSare impaired in children with T1DM and that the decrease in LV GLS is correlated with diabetes duration and HbA1c levels.
       
  • Authors reply to the letter regarding “Ticagrelor for Asian patients
           with acute coronary syndrome in real-world practice: a systematic review
           and meta-analysis of observational studies”

    • Abstract: Publication date: Available online 25 April 2019Source: Indian Heart JournalAuthor(s): Akhmetzhan Maratovich Galimzhanov, Baurzhan Slymovich Azizov
       
  • Letter to the Editor regarding"Ticagrelor for Asian patients with acute
           coronary syndrome in real-world practice: A systematic review and
           meta-analysis of observational studies". The benefit of using Person-year
           when the follow up period varies in a meta-analysis

    • Abstract: Publication date: Available online 19 April 2019Source: Indian Heart JournalAuthor(s): U. Ashish Kumar, Mariam Shariff
       
  • The report on the Indian coronary intervention data for the year 2017 –
           National Interventional Council

    • Abstract: Publication date: Available online 19 April 2019Source: Indian Heart JournalAuthor(s): Arramraju Sreenivas Kumar, Koganti Sudhir, Janapati Ramakrishna, Emmareddy Sanjeev Kumar, Mandala Gokul Reddy
       
  • Image based simulative training for myectomy in hypertrophic
           cardiomyopathy: an emerging necessity.

    • Abstract: Publication date: Available online 16 April 2019Source: Indian Heart JournalAuthor(s): V Rao Parachuri, Srilakshmi M. Adhyapak Surgical myectomy was initially advocated only for patients with symptoms refractory to maximal tolerated medical therapy. These were mainly symptoms of cardiac failure. In recent times, there has been a call for revision of guidelines to include patients earlier. As the disease progression cannot be reversed by most currently used drugs which become ineffective with time, this need for earlier myectomy seems mandatory. Presently, surgical expertise in myectomy is limited to specialized centers. The complexity of surgical myectomy is enhanced by the complex and variable anatomic substrate. With the need for earlier myectomy, a vast population of patients with hypertrophic cardiomyopathy will need surgerypredicating a requirement for more skilled cardiac surgeons. Mentoring programs in specialized centers may not be the solution, as is training surgeons using image guided simulation techniques. Here, we discuss the existing simulative techniques and novel image-based pre-operative planning techniques which may help guide myectomy.
       
  • Resolution of Primary Aortic Thrombosis after Dabigatran therapy – A New
           hope for the rare and old disease

    • Abstract: Publication date: Available online 1 April 2019Source: Indian Heart JournalAuthor(s): Pankaj Jariwala, Satya Sridhar Kale The primary aortic thrombosis [PAT] is an uncommon non-cardiac cause of distal peripheral embolization to lower extremities. Also, this condition develops in the absence of extensive atherosclerosis of aorta or abnormal dilatation like aneurysm of the aorta. In most of the cases, there was either no or minimal atherosclerosis of the aorta. The disease can involve any part of the aorta but in most of the cases, thoracic aorta below the origin of the left subclavian artery followed by the infra-renal portion of the abdominal aorta were the most common site of involvement. In our case, there was extensive thrombosis starting from the lower part of the thoracic aorta extending across both the renal arteries up to the aortic bifurcation without any underlying aortic pathology or hypercoagulable disease. There are no guidelines for the management of the primary aortic thrombosis but our experience is based upon few case series, case reports, and meta-analysis where there are variable success rate using either conservative medical management, endovascular procedure or surgical thrombectomy. Vitamin-K- antagonist [VKA] was the drug of choice in all the cases as a part of conservative medical management or used to prevent recurrence after the endovascular or surgical procedure.We present a case of primary aortic thrombosis where the use of dabigatran lead to complete resolution and prevented the recurrence of the disease during two years follow-up which is first and unique case report of the literature.
       
  • Incidence, predictors and gradation of upper extremity venous obstruction
           after transvenous pacemaker implantation

    • Abstract: Publication date: Available online 14 March 2019Source: Indian Heart JournalAuthor(s): Jayaprakash Shenthar, Deepak Padmanabhan, Bharatraj Banavalikar, Javed Parvez, Sanjai Pattu Vallapil, Inoatan Singha, Vivek Tripathi
       
  • Effects Of Home-Based Exercise Training On Functional Outcomes And Quality
           Of Life In Patients With Pulmonary Hypertension: A Randomized Clinical
           Trial

    • Abstract: Publication date: Available online 9 March 2019Source: Indian Heart JournalAuthor(s): Abraham Samuel Babu, Ramachandran Padmakumar, Krishnanand Nayak, Ranjan Shetty, Aswini Kumar Mohapatra, Arun G. Maiya ObjectivesTo assess the effects of home-based exercise training (HBET) on function and quality of life (QoL) in PH.MethodsA prospective, non-blinded, randomized clinical trial was carried out on 84, medically stable patients with PH belonging to any functional class or etiology and of either sex. Patients were randomized to either standard care or to HBET. Both groups also received education with the Pulmonary Hypertension Manual (PulHMan). Outcomes included functional capacity from six minute walk distance (6MWD), QoL using the SF36, functional class (FC) and right heart indices (right ventricular systolic pressure, RVSP and tricuspid annual plane systolic excursion, TAPSE) and were assessed at entry and after 12-weeks.ResultsHBET improved six-minute walk distance by 48.5m and 13m in the experimental and control groups respectively (p
       
  • Door-to-needle time in myocardial infarction: Small steps, huge dividends

    • Abstract: Publication date: Available online 9 March 2019Source: Indian Heart JournalAuthor(s): Vivek Chauhan, Bhagwan Das Negi, Gurudutt Sharma The Himachal Pradesh acute coronary syndrome registry highlighted a pre-hospital delay of 780 minutes. Additional door-to-needle time delay by 1 hour increases the hazard ratio of death by 20%. We conducted a retrospective (group 1) and a prospective (group 2) analysis of 63 patients each to measure the impact of a fast-track protocol in emergency department (ED) on the door-to-needle time in St-elevation myocardial infarction (STEMI). The fast-track protocol involved zero cost to the hospital and saved 63 precious door-to-needle minutes for STEMI patients. Thrombolysis in ED can save 33 precious minutes wasted in shifting patients to the coronary-care unit.
       
  • Letter to the editor regarding “Role of cytochrome epoxygenase (CYP2J2)
           in the pathophysiology of coronary artery disease in South Indian
           Population.”

    • Abstract: Publication date: Available online 23 February 2019Source: Indian Heart JournalAuthor(s): U. Ashish Kumar, Mariam Shariff
       
  • Prevalence of Familial Hypercholesterolemia in premature Coronary Artery
           Disease patients admitted to a tertiary care hospital in North India

    • Abstract: Publication date: Available online 3 January 2019Source: Indian Heart JournalAuthor(s): J.P.S. Sawhney, Shashi Ranjan Prasad, Manish Sharma, Kushal Madan, A. Mohanty, Rajiv Passey, Ashwani Mehta, B. Kandpal, Aman Makhija, Rajneesh Jain, R.R. Mantri, Bhola Shankar Vivek, S.C. Manchanda, I.C. Verma ObjectivesThe prevalence of premature coronary artery disease (CAD) in India is 2 to 3 times more than other ethnic groups. Untreated heterozygous familial hypercholesterolemia (FH) is one of the important causes for premature CAD. As the age advances, these patients without treatment have 100 times increased risk of cardiovascular mortality resulting from Myocardial Infarction (MI). Recent evidence suggests that 1 in 250 individuals may be affected by FH (nearly 40 million people globally). It is indicated that the true global prevalence of FH is underestimated. The true prevalence of FH in India remains unknown.MethodsA total of 635 patients with premature CAD were assessed for FH using the Dutch Lipid Clinical Network (DLCN) criteria. Based on scores patients were diagnosed as definite, probable, possible or No FH. Other cardiovascular risk factors known to cause CAD such as smoking, diabetes mellitus DM and hypertension were also recorded.ResultsOf total 635 patients, 25 (4%) were diagnosed as definite, 70 (11%) as probable, 238 (37%) as possible and 302 (48%) without FH, suggesting the prevalence of potential (definite + probable) FH of about 15% in North Indian population. FH is more common in younger patients and they have lesser incidence of common CV risk factors like diabetes, hypertension and smoking as compared to younger MI patients without FH (26.32% vs.42.59%; 17.89% vs.29.44%; 22.11% vs.40.74%).ConclusionFH prevalence is high among patients with premature CAD admitted to a cardiac unit. To detect patients with FH, routine screening with simple criteria such as family history of premature CAD combined with hypercholesterolemia and a DLCNC>5 may be effectively used.
       
 
 
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