Publisher: Elsevier   (Total: 3207 journals)

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Showing 1 - 200 of 3207 Journals sorted alphabetically
Academic Pediatrics     Hybrid Journal   (Followers: 39, SJR: 1.655, CiteScore: 2)
Academic Radiology     Hybrid Journal   (Followers: 27, SJR: 1.015, CiteScore: 2)
Accident Analysis & Prevention     Hybrid Journal   (Followers: 108, SJR: 1.462, CiteScore: 3)
Accounting Forum     Hybrid Journal   (Followers: 30, SJR: 0.932, CiteScore: 2)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 46, SJR: 1.771, CiteScore: 3)
Achievements in the Life Sciences     Open Access   (Followers: 8)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 6)
Acta Astronautica     Hybrid Journal   (Followers: 459, SJR: 0.758, CiteScore: 2)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 2)
Acta Biomaterialia     Hybrid Journal   (Followers: 30, SJR: 1.967, CiteScore: 7)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 3)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 11, SJR: 0.18, CiteScore: 1)
Acta Histochemica     Hybrid Journal   (Followers: 5, SJR: 0.661, CiteScore: 2)
Acta Materialia     Hybrid Journal   (Followers: 348, SJR: 3.263, CiteScore: 6)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.504, CiteScore: 1)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.542, CiteScore: 1)
Acta Oecologica     Hybrid Journal   (Followers: 12, SJR: 0.834, CiteScore: 2)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription  
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 2, SJR: 0.307, CiteScore: 0)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 3, SJR: 1.793, CiteScore: 6)
Acta Psychologica     Hybrid Journal   (Followers: 27, SJR: 1.331, CiteScore: 2)
Acta Sociológica     Open Access   (Followers: 1)
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.052, CiteScore: 2)
Acta Urológica Portuguesa     Open Access   (Followers: 1)
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3, SJR: 0.374, CiteScore: 1)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.344, CiteScore: 1)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 1)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 7, SJR: 0.19, CiteScore: 0)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 3)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 9)
Acute Pain     Full-text available via subscription   (Followers: 15, SJR: 2.671, CiteScore: 5)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.53, CiteScore: 4)
Addictive Behaviors     Hybrid Journal   (Followers: 18, SJR: 1.29, CiteScore: 3)
Addictive Behaviors Reports     Open Access   (Followers: 9, SJR: 0.755, CiteScore: 2)
Additive Manufacturing     Hybrid Journal   (Followers: 15, SJR: 2.611, CiteScore: 8)
Additives for Polymers     Full-text available via subscription   (Followers: 22)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 206, SJR: 4.09, CiteScore: 13)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 13, SJR: 1.167, CiteScore: 4)
Advanced Powder Technology     Hybrid Journal   (Followers: 17, SJR: 0.694, CiteScore: 3)
Advances in Accounting     Hybrid Journal   (Followers: 9, SJR: 0.277, CiteScore: 1)
Advances in Agronomy     Full-text available via subscription   (Followers: 20, SJR: 2.384, CiteScore: 5)
Advances in Anesthesia     Full-text available via subscription   (Followers: 31, SJR: 0.126, CiteScore: 0)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 2)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 12, SJR: 0.992, CiteScore: 1)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 12, SJR: 1.551, CiteScore: 4)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 24, SJR: 2.089, CiteScore: 5)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 0.572, CiteScore: 2)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.61, CiteScore: 7)
Advances in Botanical Research     Full-text available via subscription   (Followers: 2, SJR: 0.686, CiteScore: 2)
Advances in Cancer Research     Full-text available via subscription   (Followers: 35, SJR: 3.043, CiteScore: 6)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 1.453, CiteScore: 2)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 1.992, CiteScore: 5)
Advances in Cell Aging and Gerontology     Full-text available via subscription   (Followers: 6)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 14)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 29, SJR: 0.156, CiteScore: 1)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 11, SJR: 0.713, CiteScore: 1)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 11, SJR: 1.316, CiteScore: 2)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 27, SJR: 1.562, CiteScore: 3)
Advances in Clinical Radiology     Full-text available via subscription   (Followers: 2)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 21, SJR: 1.977, CiteScore: 8)
Advances in Computers     Full-text available via subscription   (Followers: 15, SJR: 0.205, CiteScore: 1)
Advances in Cosmetic Surgery     Full-text available via subscription   (Followers: 2)
Advances in Dermatology     Full-text available via subscription   (Followers: 15)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 14)
Advances in Digestive Medicine     Open Access   (Followers: 15)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 7)
Advances in Drug Research     Full-text available via subscription   (Followers: 26)
Advances in Ecological Research     Full-text available via subscription   (Followers: 44, SJR: 2.524, CiteScore: 4)
Advances in Engineering Software     Hybrid Journal   (Followers: 31, SJR: 1.159, CiteScore: 4)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 9)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 53, SJR: 5.39, CiteScore: 8)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 2)
Advances in Family Practice Nursing     Full-text available via subscription   (Followers: 1)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 9)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 69, SJR: 0.591, CiteScore: 2)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 17)
Advances in Genetics     Full-text available via subscription   (Followers: 20, SJR: 1.354, CiteScore: 4)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11, SJR: 12.74, CiteScore: 13)
Advances in Geophysics     Full-text available via subscription   (Followers: 9, SJR: 1.193, CiteScore: 3)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 26, SJR: 0.368, CiteScore: 1)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 11, SJR: 0.749, CiteScore: 3)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 26)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 4, SJR: 0.193, CiteScore: 0)
Advances in Immunology     Full-text available via subscription   (Followers: 39, SJR: 4.433, CiteScore: 6)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 11, SJR: 1.163, CiteScore: 2)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 2, SJR: 1.938, CiteScore: 3)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6, SJR: 0.176, CiteScore: 0)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 3)
Advances in Life Course Research     Hybrid Journal   (Followers: 11, SJR: 0.682, CiteScore: 2)
Advances in Lipobiology     Full-text available via subscription   (Followers: 2)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 8)
Advances in Marine Biology     Full-text available via subscription   (Followers: 21, SJR: 0.88, CiteScore: 2)
Advances in Mathematics     Full-text available via subscription   (Followers: 17, SJR: 3.027, CiteScore: 2)
Advances in Medical Sciences     Hybrid Journal   (Followers: 9, SJR: 0.694, CiteScore: 2)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 5, SJR: 1.158, CiteScore: 3)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 26)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 8)
Advances in Molecular Pathology     Hybrid Journal   (Followers: 1)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.182, CiteScore: 0)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 5)
Advances in Oncobiology     Full-text available via subscription   (Followers: 2)
Advances in Ophthalmology and Optometry     Full-text available via subscription   (Followers: 1)
Advances in Organ Biology     Full-text available via subscription   (Followers: 2)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 19, SJR: 1.875, CiteScore: 4)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.174, CiteScore: 0)
Advances in Parasitology     Full-text available via subscription   (Followers: 6, SJR: 1.579, CiteScore: 4)
Advances in Pediatrics     Full-text available via subscription   (Followers: 27, SJR: 0.461, CiteScore: 1)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 19)
Advances in Pharmacology     Full-text available via subscription   (Followers: 17, SJR: 1.536, CiteScore: 3)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 10, SJR: 0.574, CiteScore: 1)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.109, CiteScore: 1)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 10)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 6)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 19, SJR: 0.791, CiteScore: 2)
Advances in Psychology     Full-text available via subscription   (Followers: 71)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 7, SJR: 0.371, CiteScore: 1)
Advances in Radiation Oncology     Open Access   (Followers: 3, SJR: 0.263, CiteScore: 1)
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.101, CiteScore: 0)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 7)
Advances in Space Research     Full-text available via subscription   (Followers: 442, SJR: 0.569, CiteScore: 2)
Advances in Structural Biology     Full-text available via subscription   (Followers: 6)
Advances in Surgery     Full-text available via subscription   (Followers: 12, SJR: 0.555, CiteScore: 2)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 37, SJR: 2.208, CiteScore: 4)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 21)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 15)
Advances in Virus Research     Full-text available via subscription   (Followers: 6, SJR: 2.262, CiteScore: 5)
Advances in Water Resources     Hybrid Journal   (Followers: 58, SJR: 1.551, CiteScore: 3)
Aeolian Research     Hybrid Journal   (Followers: 6, SJR: 1.117, CiteScore: 3)
Aerospace Science and Technology     Hybrid Journal   (Followers: 408, SJR: 0.796, CiteScore: 3)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.42, CiteScore: 2)
African J. of Emergency Medicine     Open Access   (Followers: 6, SJR: 0.296, CiteScore: 0)
Ageing Research Reviews     Hybrid Journal   (Followers: 12, SJR: 3.671, CiteScore: 9)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 487, SJR: 1.238, CiteScore: 3)
Agri Gene     Hybrid Journal   (Followers: 1, SJR: 0.13, CiteScore: 0)
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 18, SJR: 1.818, CiteScore: 5)
Agricultural Systems     Hybrid Journal   (Followers: 32, SJR: 1.156, CiteScore: 4)
Agricultural Water Management     Hybrid Journal   (Followers: 47, SJR: 1.272, CiteScore: 3)
Agriculture and Agricultural Science Procedia     Open Access   (Followers: 4)
Agriculture and Natural Resources     Open Access   (Followers: 3)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 59, SJR: 1.747, CiteScore: 4)
Ain Shams Engineering J.     Open Access   (Followers: 7, SJR: 0.589, CiteScore: 3)
Air Medical J.     Hybrid Journal   (Followers: 8, SJR: 0.26, CiteScore: 0)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.19, CiteScore: 0)
Alcohol     Hybrid Journal   (Followers: 12, SJR: 1.153, CiteScore: 3)
Alcoholism and Drug Addiction     Open Access   (Followers: 12)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 2)
Alexandria Engineering J.     Open Access   (Followers: 3, SJR: 0.604, CiteScore: 3)
Alexandria J. of Medicine     Open Access   (Followers: 1, SJR: 0.191, CiteScore: 1)
Algal Research     Partially Free   (Followers: 11, SJR: 1.142, CiteScore: 4)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.504, CiteScore: 1)
Allergology Intl.     Open Access   (Followers: 5, SJR: 1.148, CiteScore: 2)
Alpha Omegan     Full-text available via subscription   (SJR: 3.521, CiteScore: 6)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 12, SJR: 0.201, CiteScore: 1)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 60, SJR: 4.66, CiteScore: 10)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 6, SJR: 1.796, CiteScore: 4)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 6, SJR: 1.108, CiteScore: 3)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 5)
American Heart J.     Hybrid Journal   (Followers: 60, SJR: 3.267, CiteScore: 4)
American J. of Cardiology     Hybrid Journal   (Followers: 68, SJR: 1.93, CiteScore: 3)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 51, SJR: 0.604, CiteScore: 1)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 13)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 17, SJR: 1.524, CiteScore: 3)
American J. of Human Genetics     Hybrid Journal   (Followers: 41, SJR: 7.45, CiteScore: 8)
American J. of Infection Control     Hybrid Journal   (Followers: 36, SJR: 1.062, CiteScore: 2)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 37, SJR: 2.973, CiteScore: 4)
American J. of Medicine     Hybrid Journal   (Followers: 51)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3, SJR: 1.967, CiteScore: 2)
American J. of Obstetrics & Gynecology MFM     Hybrid Journal   (Followers: 2)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 281, SJR: 2.7, CiteScore: 4)
American J. of Ophthalmology     Hybrid Journal   (Followers: 69, SJR: 3.184, CiteScore: 4)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 6, SJR: 0.265, CiteScore: 0)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.289, CiteScore: 1)
American J. of Otolaryngology     Hybrid Journal   (Followers: 25, SJR: 0.59, CiteScore: 1)
American J. of Pathology     Hybrid Journal   (Followers: 33, SJR: 2.139, CiteScore: 4)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 29, SJR: 2.164, CiteScore: 4)
American J. of Surgery     Hybrid Journal   (Followers: 39, SJR: 1.141, CiteScore: 2)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.767, CiteScore: 1)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 7)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.144, CiteScore: 3)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 70, SJR: 0.138, CiteScore: 0)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 27, SJR: 0.411, CiteScore: 1)
Anales de Cirugia Vascular     Full-text available via subscription   (Followers: 1)
Anales de Pediatría     Full-text available via subscription   (Followers: 3, SJR: 0.277, CiteScore: 0)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription  
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 7, SJR: 4.849, CiteScore: 10)
Analytica Chimica Acta     Hybrid Journal   (Followers: 44, SJR: 1.512, CiteScore: 5)
Analytica Chimica Acta : X     Open Access  
Analytical Biochemistry     Hybrid Journal   (Followers: 230, SJR: 0.633, CiteScore: 2)
Analytical Chemistry Research     Open Access   (Followers: 14, SJR: 0.411, CiteScore: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 14)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 2)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 24, SJR: 0.683, CiteScore: 2)

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Similar Journals
Journal Cover
Epilepsy & Behavior Case Reports
Journal Prestige (SJR): 0.42
Citation Impact (citeScore): 1
Number of Followers: 4  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2213-3232
Published by Elsevier Homepage  [3207 journals]
  • Family association of genetic generalised epilepsy with limb-girdle
           muscular dystrophy through a mutation in CAPN3

    • Abstract: Publication date: Available online 21 March 2019Source: Epilepsy & Behavior Case ReportsAuthor(s): Alejandro Viloria-Alebesque, Elena Bellosta-Diago, Sonia Santos-Lasaosa, José Ángel Mauri-Llerda
       
  • Asymptomatic carotid acute dissection following focal status epilepticus

    • Abstract: Publication date: Available online 17 March 2019Source: Epilepsy & Behavior Case ReportsAuthor(s): Fedele Dono, Francesca Anzellotti, Mirella Russo, Claudia Carrarini, Stefania Nanni, Camilla Ferrante, Maria Vittoria De Angelis, Marco Onofrj
       
  • A Study of Convulsive Status Epilepticus Cases in Indonesia

    • Abstract: Publication date: Available online 14 March 2019Source: Epilepsy & Behavior Case ReportsAuthor(s): Machlusil Husna, K. Shahdevi Nandar, Risma Karlina Prabawati, Siti Nurlaela Status epilepticus (SE) is a serious health issue in developing countries, with high morbidity and mortality rates of 3%–46%. There are two types of SE, convulsive status epilepticus (CSE) and non-convulsive status epilepticus. The most common type, CSE, is easy to detect but, in several cases, the patients are diagnosed too late to be properly treated and hospitalized. The present study therefore investigated the clinical manifestations of CSE in Indonesia. Patients with CSE treated at a tertiary hospital in Malang, Indonesia were observed retrospectively. Data on patients’ clinical conditions and demographic characteristics were obtained from medical records. In total, 136 patients were diagnosed with CSE (male:female = 1.52:1), and almost one-third of this group were> 50 years of age (30%). Most patients (80.1%) suffered from general tonic–clonic seizures with an onset> 6 h after arrival at the hospital emergency room (63.2%). The most common etiology was withdrawal from an anti-seizure (anti-epileptic) drug (31.6%), followed by stroke (24.3%). Patients were treated with diazepam (58.1%), phenytoin (89.7%), and anesthetic drugs (11.8%), 61.8% of the patients overcame seizures. The fatality rate was 19.9%, with the most common causes of death being brain herniation (37.0%), septic shock (29.6%), and respiratory failure (11.1%).
       
  • Evolution of Epileptogenesis in response to head trauma and acute
           

    • Abstract: Publication date: Available online 7 March 2019Source: Epilepsy & Behavior Case ReportsAuthor(s): Alexandra T. Issa Roach, Diana Pizarro, Hrishikesh D. Deshpande, Sandipan Pati, Jerzy P. Szaflarski, Kristen O. Riley, Wolfgang Muhlhofer, Thomas Houston We present a unique case of a patient with medically refractory focal epilepsy undergoing presurgical stereoelectroencephalography (sEEG) evaluation who developed an acute post-traumatic intracranial hemorrhage during monitoring. Our case demonstrates the evolution of the electrographic changes at the time of the initial hemorrhage to the development of ictal activity. We conducted spectral analysis of the sEEG data to illustrate the transition from an interictal to ictal state. Initially, delta power increased in the region of acute hemorrhage, followed by a sustained regional reduction in frequency variability. Our findings provide further information on the development of epileptiform activity in acute hemorrhage.
       
  • Surgically treated intracranial supratentorial calcifying pseudoneoplasms
           of the neuraxis (CAPNON) with drug-resistant left temporal lobe epilepsy:
           A case report and review of the literature

    • Abstract: Publication date: Available online 7 March 2019Source: Epilepsy & Behavior Case ReportsAuthor(s): Yuta Tanoue, Takehiro Uda, Kosuke Nakajo, Shugo Nishijima, Tsuyoshi Sasaki, Kenji Ohata Calcifying pseudoneoplasms of the neuraxis (CAPNON) is a rare pathological lesion that can present anywhere in the central nervous system. Symptoms vary depending on the location, though they often include seizures, especially in intracranial and supratentorial lesions. A case of intracranial supratentorial CAPNON presenting with drug-resistant left temporal lobe epilepsy is reported. The patient had a history of drug-resistant seizures for over 36 years. The lesion was in the left mesial temporal lobe, but features of hippocampal sclerosis or hippocampal invasion were not apparent. The lesion was removed without hippocampectomy, and the patient has been seizure-free for one year.
       
  • Forced normalization after turning off vagus nerve stimulation in
           Lennox–Gastaut syndrome

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Sydney Lee, Alyssa Denton, Lady Diana Ladino, Karen Waterhouse, Aleksander Vitali, Jose Francisco Tellez-Zenteno Forced normalization is the development of psychiatric symptoms in a patient experiencing remission of seizures. We present a case of Lennox Gastaut syndrome in which forced normalization developed after vagus nerve stimulation was stopped.The patient had drug resistant epilepsy and failed anti-seizure drugs, vagus nerve stimulation, and a partial callosotomy.The patient had multiple types of seizures including drop attacks, absences, and tonic–clonic seizures. He tried vagus nerve stimulation for two years without success. Forced normalization developed after the vagus nerve stimulator was turned off.This is the first case to our knowledge to describe forced normalization after turning off the vagus nerve stimulator.
       
  • Probable sporadic Creutzfeldt–Jakob disease mimicking focal epilepsy

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Pei-Shan Hsiao, Yuan-Ming Lee, Fu-Sin Chu, Chao-Lin Lee, Fang-Chun Liu, Ping-Huang Tsai Creutzfeldt–Jakob disease (CJD) presents with seizures as an early symptom in only approximately 3% of cases. These seizures often present as nonconvulsive status epilepticus (NCSE) or epilepsia partialis continua (EPC). Here, we describe a case of probable sporadic CJD (sCJD) in an 83-year-old man whose manifest an unusual presentation of left-hand tonic seizures without evolution to EPC, as well as brain MRI findings interpreted as peri-ictal changes, which led to an initial misdiagnosis of focal epilepsy.
       
  • A case of ictal burst-suppression

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Pegah Afra, Verena Clarissa Samara, Lilly Fagatele, Bola Adamolekun “Burst-suppression” pattern consists of complete attenuation of background between bursts of mixed frequencies, variable morphology and waveforms. It is a subgroup of periodic patterns seen in severe cerebral damage, anesthesia or prematurity. Here, we present a 46-year-old woman with post-anoxic encephalopathy on cooling protocol with two electrographically similar patterns of burst-suppression (one with a clinical ictal correlate of isolated eye movements), as well as three electroclinical seizures. The literature on rare clinical phenomenon of isolated eye movements associated with burst-suppression is reviewed, with the conclusion that the presented case suggests an ictal origin.
       
  • A case of auditory disturbance caused by lacosamide

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Mihoko Kawai, Kousuke Kanemoto We report a case of auditory disturbance in an adult female that developed after starting lacosamide treatment for epilepsy. While carbamazepine is known to change auditory pitch perception in some patients, that has not been previously reported as a side effect of lacosamide administration. In our description of pitch perception deficit associated with lacosamide, we outline features seen in our patient and compare our findings with those of previous reports describing carbamazepine-associated auditory disturbance.
       
  • Perampanel in lissencephaly-associated epilepsy

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Satoru Ikemoto, Shin-ichiro Hamano, Yuko Hirata, Ryuki Matsuura, Reiko Koichihara We retrospectively investigated whether perampanel (PER) could serve as an alternative for treating drug-resistant seizures in lissencephaly. We investigated the following data: age at onset of epilepsy, age at start of PER, etiology, brain MRI findings, seizure type, seizure frequency, adverse effects, and concomitant anti-epileptic drugs. There were 5 patients with lissencephaly, including 2 with Miller–Dieker syndrome. Four out of five patients exhibited ≥ 50% seizure reduction. Myoclonic seizures disappeared in 1 patient. PER was an effective adjunctive anti-seizure drug in our series of patients with lissencephaly.
       
  • Longitudinal brain functional and structural connectivity changes after
           hemispherotomy in two pediatric patients with drug-resistant epilepsy

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Yongxin Li, Ya Wang, Zhen Tan, Qian Chen, Wenhua Huang The main focus of the present study was to explore the longitudinal changes in the brain executive control system and default mode network after hemispherotomy. Resting-state functional magnetic resonance imaging and diffusion tensor imaging were collected in two children with drug-resistnt epilepsy underwent hemispherotomy. Two patients with different curative effects showed different trajectories of brain connectivity after surgery. The failed hemispherotomy might be due to the fact that the synchrony of epileptic neurons in both hemispheres is preserved by residual neural pathways. Loss of interhemispheric correlations with increased intrahemispheric correlations can be considered as neural marker for evaluating the success of hemispherotomy.
       
  • Adult-onset Rasmussen's Syndrome with associated cortical dysplasia

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): C. Ákos Szabó, Rachel Garvin, Shaheryar Hafeez, Ali Seifi, Linda Leary, Ratna Bhavaraju-Sanka, James M. Henry, Alex M. Papanastassiou We describe a 23-year-old woman with previous right temporal lobe surgeries for underlying cortical dysplasia, presenting with drug-resistant right hemispheric seizures and epilepsia partialis continua (EPC). After anti-seizure medication adjustments, she developed focal status epilepticus with progressive EEG and neuroimaging changes. Cerebrospinal fluid and serum autoimmune panels were negative except for an elevated serum acetylcholine-receptor antibody titer, but she underwent immunosuppressive therapy. Stereotactic-EEG evaluation demonstrated multifocal independent ictal patterns in the right hemisphere. Rasmussen's Syndrome was confirmed by brain biopsy, and a hemispherectomy was performed. This patient demonstrates the rare association of adult-onset EPC with cortical dysplasia, precipitously evolving into Rasmussen's Syndrome.
       
  • Are there mortality risks for patients with epilepsy who use cannabis
           treatments as monotherapy'

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Devon M. Kollmyer, Kyla E. Wright, Nicole M. Warner, Michael J. Doherty Mortality associated with cannabis used for treatment of epilepsy is not well documented. We discuss two fatalities in the setting of epilepsy and self-determined therapy with cannabis (SDTC). One patient had probable sudden unexpected death in epilepsy, the second death was due to seizure-associated drowning. Both directed SDTC over conventional anti-seizure medications. Where recreational cannabis is legal, decisions to use cannabis are often self-directed and independent of physician advice of cannabis risks, in part because physicians may not be aware of the risk of SDTC. Further study of morbidity and mortality of SDTC in patients with epilepsy is needed.
       
  • Ictal asystole with isolated syncope: A case report and literature review

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Wenyang Li, Lakshman Arcot Jayagopal, Olga Taraschenko Ictal syncope is a rare phenomenon that occurs in association with 0.002–0.4% of seizures. In the absence of other symptoms, seizures presenting with syncope may be challenging to diagnose. We report a case of a previously healthy male who developed recurrent episodes of syncope with postictal confusion and was later diagnosed with temporal seizures. The patient was successfully treated with anti-seizure drugs and placement of a cardiac pacemaker. In a systematic review of literature, we summarize the clinical characteristics of patients with ictal asystole and isolated syncope. Seizures should be considered in patients with syncope of uncertain etiology.
       
  • Nonconvulsive status epilepticus secondary to acute porphyria crisis

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Sara Dawit, Shubhang K. Bhatt, Devika M. Das, Andrew R. Pines, Harn J. Shiue, Brent P. Goodman, Joseph F. Drazkowski, Joseph I. Sirven Both variegate and acute intermittent porphyria can manifest with various neurological symptoms. Although acute symptomatic seizures have been previously described, they are typically tonic–clonic and focal impaired awareness seizures. Convulsive status epilepticus and epilepsia partialis continua are rare and have been described on a case report basis. To our knowledge, there are no previously reported cases describing non-convulsive status epilepticus (NCSE) with electroencephalogram (EEG) documentation in the setting of acute porphyria crisis. We report a unique presentation of NCSE, which resolved after administering levetiracetam in a patient with variegate porphyria, without a known seizure disorder.
       
  • Hemi-ESES associated with agenesis of the corpus callosum and normal
           cognition

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Mahmoud Mohammadi, Safoura kowkabi, Ali A. Asadi-Pooya, Reza Azizi Malamiri, Reza Shervin Badv
       
  • Epilepsy phenotype in patients with Xp22.31 microduplication

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Mario Brinciotti, Francesca Fioriello, Antonio Mittica, Laura Bernardini, Marina Goldoni, Maria Matricardi The clinical significance of Xp22.31 microduplication is still unclear. We describe a family in which a mother and two children have Xp22.31 microduplication associated with different forms of epilepsy and epileptiform EEG abnormalities. The proband had benign epilepsy with centrotemporal spikes with dysgraphia and dyscalculia (IQ 72), the sister had juvenile myoclonic epilepsy, and both had bilateral talipes anomalies. The mother, who was the carrier of the microduplication, was asymptomatic. The asymptomatic father did not possess the microduplication. These data contribute to delineate the phenotype associated with Xp22.31 microduplication and suggest a potential pathogenic role for an epilepsy phenotype.
       
  • Mesial temporal extraventricular neurocytoma (mtEVN): A case report and
           literature review

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Angie Zhang, Daniel F. Brown, Efkan M. Colpan We describe a case of mesial temporal extraventricular neurocytoma (mtEVN) in a 23-year-old male presenting with drug-resistant seizures and review the literature on this rare tumor.A PubMed search was queried using the MeSH term “neurocytoma” and key search terms “extraventricular”, “temporal”, and “epilepsy”. Titles and abstracts were screened for temporal neurocytomas. References were reviewed to identify further studies.Twenty case reports were selected comparing the presentation, radiological, histopathological, and surgical outcomes of neocortex temporal EVNs (ntEVN) and mtEVNs.Gross total resection of mtEVNs under intraoperative electrocorticography monitoring typically affords an excellent prognosis and successful seizure control.
       
  • Ability to knit may be impaired following right temporal lobe resection
           for drug-resistant epilepsy

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Sallie Baxendale
       
  • Sleep is associated with reduction of epileptiform discharges in benign
           adult familial myoclonus epilepsy

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Takefumi Hitomi, Morito Inouchi, Hirofumi Takeyama, Katsuya Kobayashi, Shamima Sultana, Takeshi Inoue, Yuko Nakayama, Akihiro Shimotake, Masao Matsuhashi, Riki Matsumoto, Kazuo Chin, Ryosuke Takahashi, Akio Ikeda To clarify the effects of sleep on cortical irritability in benign adult familial myoclonus epilepsy (BAFME), we retrospectively compared epileptiform discharges of electroencephalographies (EEGs) between awake and sleep periods in 5 patients (mean age: 49.6 ± 20.3 years). We also analyzed polysomnography (PSG) of 1 patient. Epileptiform discharges were significantly more frequent during the awake period (1.3 ± 1.2/min) than those during light sleep stages (0.02 ± 0.04/min) (P 
       
  • Down syndrome associated moyamoya may worsen epilepsy control and can
           benefit from surgical revascularization

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Sarah R. Garson, Stephen J. Monteith, Sheila D. Smith, Bart P. Keogh, Ryder P. Gwinn, Michael J. Doherty ObjectivesTo examine outcome of bilateral extracranial to intracranial (EC-IC) bypass surgeries for a Down syndrome patient with hard-to-treat epilepsy and moyamoya.Materials and methodsSuperficial temporal arteries were anastamosed using an indirect bypass technique to middle cerebral arteries bilaterally to help limit perfusion deficits and seizure controls.ResultsTwo superficial temporal to middle cerebral artery indirect bypass surgeries were performed within 3 months. Post-revascularization improvements included seizure control, gait, perfusion, wakefulness, language and quality of life.ConclusionIn patients with Down syndrome and moyamoya, improvements in seizure control and quality of life may occur with EC-IC bypass procedures.
       
  • Anatomo-electro-clinical correlations of hypermotor seizures with amygdala
           enlargement: Hippocampal seizure origin identified using
           stereoelectroencephalography

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Tomotaka Ishizaki, Satoshi Maesawa, Daisuke Nakatsubo, Hiroyuki Yamamoto, Masashi Shibata, Sachiko Kato, Mari Yoshida, Jun Natsume, Minoru Hoshiyama, Toshihiko Wakabayashi
       
  • Heterotopia or overlaying cortex: What about in-between'

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Emilija Cvetkovska, William Alves Martins, Jorge Gonzalez-Martinez, Ken Taylor, Jian Li, Olesya Grinenko, John Mosher, Richard Leahy, Patrick Chauvel, Dileep Nair We describe a patient with unilateral periventricular nodular heterotopia (PNH) and drug-resistant epilepsy, whose SEEG revealed that seizures were arising from the PNH, with the almost simultaneous involvement of heterotopic neurons (“micronodules”) scattered within the white matter, and subsequently the overlying cortex. Laser ablation of heterotopic nodules and the adjacent white matter rendered the patient seizure free.This case elucidates that “micronodules” scattered in white matter between heterotopic nodules and overlying cortex might be another contributor in complex epileptogenicity of heterotopia. Detecting patient-specific targets in the epileptic network of heterotopia creates the possibility to disrupt the pathological circuit by minimally invasive procedures.
       
  • Epileptic spasms as the presenting seizure type in a patient with a new
           “O” of TORCH, congenital Zika virus infection

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Jason Lockrow, Hannah Tully, Russell P. Saneto Congenital TORCH infections are a significant cause of epileptic spasms, an infantile epileptic encephalopathy, through disruptions to several pathways in neurodevelopment. Congenital Zika virus has a similar neurotropism to other TORCH agents, and leads to microcephaly, severe neurodevelopmental impairment, and high rates of early onset seizures. Here we report a child with confirmed congenital Zika virus who developed extensor epileptic spasms and hypsarrhythmia associated with a loss of early developmental milestones. Early treatment led to resolution of epileptic spasms and improved developmental trajectory, though the child continues to have ongoing focal seizures and prominent developmental impairment. Congenital Zika virus infection requires close monitoring as early identification of epileptic spasms is likely important in long term developmental outcome.
       
  • Long term seizure freedom on perampanel in highly drug-resistant epilepsy
           caused by bilateral periventricular nodular heterotopia: A case report

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Makoto Kiyose, Marlies Wagner, Annika Männer, Sarah C. Reitz, Karl Martin Klein, Adam Strzelczyk, Sebastian Bauer, Felix Rosenow
       
  • Non-convulsive status epilepticus associated with neuronal intranuclear
           inclusion disease: A case report and literature review

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Kazumasa Shindo, Mai Tsuchiya, Takanori Hata, Yuta Ichinose, Kishin Koh, Jun Sone, Takamura Nagasaka, Gen Sobue, Yoshihisa Takiyama We report a case of neuronal intranuclear inclusion disease (NIID) confirmed by detection of intranuclear inclusions in a skin biopsy specimen. Brain magnetic resonance imaging showed mild cerebral atrophy and linear hyperintensities at the corticomedullary junction on diffusion-weighted images. This patient developed nonconvulsive status epilepticus with generalized periodic discharges on electroencephalography after recurrent symptoms of paroxysmal nausea and slowly progressive cognitive decline. There have been no previous reports of NIID with nonconvulsive status epilepticus to our knowledge. Since adult patients with NIID display a wide variety of clinical manifestations, skin biopsy should be considered in patients who have leukoencephalopathy of unknown origin.
       
  • Perampanel: A therapeutic alternative in refractory status epilepticus
           associated with MELAS syndrome

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Estevo Santamarina, Alicia Alpuente, Olga Maisterra, María Sueiras, Silvana Sarria, Lorena Guzman, Laura Abraira, Javier Salas-Puig, Manuel Toledo To our knowledge, there are no reports of status epilepticus (SE) associated with mitochondrial diseases and treated with perampanel (PER). We present three cases of patients with refractory SE associated with MELAS syndrome who responded favorably to PER.All cases were diagnosed as non-convulsive SE (focal without impairment of level of consciousness). After an initial treatment with other anti-seizure drugs, PER was added in all cases (8, 16 and 12 mg) and cessation of SE was observed within the next 4-8 hours. All the cases involved a stroke-like lesion present on brain MRI.In our patients, PER was an effective option in SE associated with MELAS syndrome.
       
  • Continuous ictal discharges with high frequency oscillations confined to
           the non-sclerotic hippocampus in an epileptic patient with
           radiation-induced cavernoma in the lateral temporal lobe

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Nobutaka Mukae, Takato Morioka, Michiko Torio, Ayumi Sakata, Satoshi O. Suzuki, Koji Iihara Intraoperative electrocorticography recording is recommended for treating cavernoma-related epilepsy. However, interictal paroxysmal epileptiform activity is generally able to be recorded, but is not always identical to the epileptogenic zone.We surgically treated a 15-year-old girl with drug-resistant epilepsy associated with radiation-induced cavernoma in the right lateral temporal lobe. Electrocorticography revealed paroxysmal activities in the cortex around the cavernoma. Additionally, continuous subclinical “ictal” discharges with high-frequency oscillations confined to the histologically non-sclerotic hippocampus were recorded. Following additional hippocampectomy, a good seizure outcome was obtained.Intraoperative electrocorticography and high-frequency oscillation analysis revealed high epileptogenicity in the non-sclerotic hippocampus of this patient.
       
  • Preserved evoked conscious perception of phosphenes with direct
           stimulation of deafferented primary visual cortex

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Kelly L. Collins, Devapratim Sarma, Shahin Hakimian, Jeff J. Tsai, Jeffrey G. Ojemann The premise of neuro-rehabilitation after injury is to access the residual capacity of the nervous system to improve function. We describe a patient who developed a quadrantopsia and drug-resistant focal epilepsy after an arteriovenous malformation hemorrhage. Thirty years later, he underwent placement of subdural electrodes for seizure mapping. Phosphenes were elicited in the blind right visual field with stimulation of occipital cortex. This case demonstrates that visual cortex may retain functional organization after a partial subcortical visual pathway injury. This persistent conscious mapping suggests that disconnected visual cortex could serve as a region for interfacing with neural prosthetic devices for acquired blindness.
       
  • Autosomal dominant temporal lobe epilepsy associated with heterozygous
           

    • Abstract: Publication date: 2019Source: Epilepsy & Behavior Case Reports, Volume 11Author(s): Katarína Česká, Štefánia Aulická, Ondřej Horák, Pavlína Danhofer, Pavel Říha, Radek Mareček, Jan Šenkyřík, Ivan Rektor, Milan Brázdil, Hana Ošlejšková PurposeAutosomal dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy syndrome characterized by focal seizures with dominant auditory symptomatology. We present a case report of an 18-year-old patient with acute onset of seizures associated with epilepsy. Based on the clinical course of the disease and the results of the investigation, the diagnosis of ADLTE with a proven mutation in the RELN gene, which is considered causative, was subsequently confirmed. The aim of this study was to use 3 Tesla (3 T) magnetic resonance imaging (MRI) and advanced neuroimaging methods in a patient with a confirmed diagnosis of ADTLE.Methods3 T MRI brain scan and advanced neuroimaging methods were used in the standard protocols to analyzse voxel-based MRI, cortical thickness, and functional connectivity.ResultsMorphometric MRI analysis (blurred grey-white matter junctions, voxel-based morphometry, and cortical thickness analysis) did not provide any informative results. The functional connectivity analysis revealed higher local synchrony in the patient in the left temporal (middle temporal gyrus), left frontal (supplementary motor area, superior frontal gyrus), and left parietal (gyrus angularis, gyrus supramarginalis) regions and the cingulate (middle cingulate gyrus) as compared to healthy controls.ConclusionsEvidence of multiple areas of functional connectivity supports the theory of epileptogenic networks in ADTLE. Further studies are needed to elucidate this theory.
       
  • Routine replacement of a vagal nerve stimulator generator leading to
           asystole

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Keith Conti, Steven M. Falowski A 52-year-old female with a longstanding history of drug-resistant epilepsy that included focal impaired awareness seizure presented at end of service of her vagus nerve stimulator (VNS) generator. She had undergone a generator replacement in 2010 without complication. However, her latest replacement was accompanied by multiple bouts of asystole. We discuss the case, possible causes of the asystole, and its relevance to the future of VNS generator replacement and epilepsy treatment.
       
  • Epilepsy in patients with long QT syndrome type 1: A Norwegian family

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Alba González, Dag Aurlien, Kristina H. Haugaa, Erik Taubøll The congenital long QT syndrome (cLQTS) is an inherited cardiac disorder and is associated with sudden cardiac death. We describe a Norwegian family with mutations within the KCNQ1 gene causing cLQTS type 1 (LQT1) and epilepsy. The index patient had Jervell and Lange-Nielsen-syndrome (JLNS) with deafness and recurrent episodes of cardiac arrhythmia. The mother and the brother have Romano-Ward syndrome (RWS) with recurrent arrhythmias. Whereas the father has focal epilepsy and genetically verified LQT1, the sister has both focal epilepsy and RWS.Our findings are consistent with the notion that mutations in the KCNQ1 gene can cause epilepsy.
       
  • Adjunctive perampanel for glioma-associated epilepsy

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Anastasie M. Dunn-Pirio, Sarah Woodring, Eric Lipp, James E. Herndon, Patrick Healy, Mallika Weant, Dina Randazzo, Annick Desjardins, Henry S. Friedman, Katherine B. Peters Glioma-associated epilepsy is associated with excessive glutamate signaling. We hypothesized that perampanel, an amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor antagonist, would treat glioma-related epilepsy. We conducted a single-arm study of adjunctive perampanel for patients with focal-onset glioma-associated seizures. The most common related adverse events were fatigue and dizziness. Three out of 8 participants had self-reported seizure reduction and an additional 3 reported improved control. Of these 6, 5 had isocitrate dehydrogenase 1 mutant gliomas. We conclude that perampanel is safe for patients with glioma-related focal-onset epilepsy. Further study into the association between AMPA signaling, IDH1 status and seizures is warranted.
       
  • Improved seizure control and regaining cognitive milestones after vagus
           nerve stimulation revision surgery in Lennox–Gastaut syndrome

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Hilde M. Braakman, Joke Creemers, Danny M. Hilkman, Sylvia Klinkenberg, Suzanne M. Koudijs, Mariette Debeij-van Hall, Erwin M. Cornips We report a child with Lennox–Gastaut syndrome with an increase in seizure frequency and loss of psychomotor skills due to a disintegrated cervical VNS lead, not detected during standard device monitoring. The lead was completely removed and replaced by a new 303 lead on the same nerve segment. After reinitiating VNS, side effects forced us to switch it off, resulting in immediate seizure recurrence. EEG recording demonstrated a non-convulsive status epilepticus that was halted by reinitiating VNS therapy. Thereafter, he remained seizure free for eight months, and regained psychomotor development.
       
  • Epilepsy and concomitant obsessive–compulsive disorder

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Jacob S. Bird, Emiy Shah, Paul Shotbolt People with epilepsy (PWE) often suffer psychiatric symptoms which can impact them more than seizures. Affective and psychotic disorders are well recognized as occurring more frequently in PWE than the general population. Less is known about obsessive–compulsive disorder (OCD) in PWE, despite it being as disabling and distressing. We sought to explore the association between epilepsy and OCD with casereports by identifying ten PWE and concomitant OCD. Demographics, seizure classification, neurological, surgical, psychiatric and psychological treatment as well as quality of life were examined. A detailed analysis was performed for three of them, to explore the lived-experience of patients with the two conditions. This is followed by a discussion of how treatment for co-morbid epilepsy and OCD can be appropriately tailored to be patient specific and provide the greatest potential for improvement.
       
  • A case of interictal dysphoric disorder comorbid with interictal
           psychosis: Part of the same spectrum or separate entities'

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Susumu Morita, Go Taniguchi, Hidetaka Tamune, Yousuke Kumakura, Shinsuke Kondo, Kiyoto Kasai Depressive disorders in epilepsy often present characteristic clinical manifestations atypical in primary, endogenous depression. Here, we report a case of a 64-year-old woman with right mesial temporal lobe epilepsy, who complained of bizarre, antipsychotic-refractory cenesthetic hallucinations in her interictal phase, and was hospitalized after a suicide attempt. Detailed clinical observations revealed mood symptoms, which led to the diagnosis of interictal dysphoric disorder comorbid with interictal psychosis. Sertraline with low-dose aripiprazole markedly alleviated both depressive and psychotic symptoms. This case suggested that the two diagnostic entities may overlap and that depressive symptoms tend to be concurrent when concurring with psychosis, which hampers the appropriate choice of a treatment option.
       
  • Auras localized to the temporal lobe disrupt verbal memory and learning
           

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Diana Pizarro, Emilia Toth, Auriana Irannejad, Kristen O. Riley, Zeenat Jaisani, Wolfgang Muhlhofer, Roy Martin, Sandipan Pati Auras (focal aware seizure; FAS) are subjective ictal events with retained consciousness. Epileptiform activities can disrupt cognitive tasks, but studies are limited to seizures with impaired awareness. As a proof of concept, we examined the cognitive effects of direct electrical stimulation to the left hippocampus which induced a habitual FAS in a patient with left mesial temporal lobe epilepsy. During the induced habitual FAS, verbal memory performance declined significantly as compared to pre-stimulation testing. Tasks measuring auditory working memory and psychomotor processing speed were not affected by the stimulation. The study confirms that FAS can impair episodic verbal memory and learning.
       
  • d-aspartate+receptor+antibody-mediated+temporal+lobe+epilepsy+with+amygdala+enlargement+without+immunotherapy&rft.title=Epilepsy+&+Behavior+Case+Reports&rft.issn=2213-3232&rft.date=&rft.volume=">Improvement in anti-N-methyl-d-aspartate receptor antibody-mediated
           temporal lobe epilepsy with amygdala enlargement without immunotherapy

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Go Taniguchi, Hitomi Fuse, Yumiko Okamura, Harushi Mori, Shinsuke Kondo, Kiyoto Kasai, Yukitoshi Takahashi, Keiko Tanaka Focal neuroinflammation is considered one of the hypotheses for the cause of temporal lobe epilepsy (TLE) with amygdala enlargement (AE). Here, we report a case involving an adult female patient with TLE-AE characterized by late-onset seizures and cognitive impairment. Anti-N-methyl-d-aspartate receptor (NMDAR) antibodies were detected in her cerebrospinal fluid. However, administration of appropriate anti-seizure drugs (ASD), without immunotherapy, improved TLE-AE associated with NMDAR antibodies. In the present case, two clinically significant observations were made: 1) anti-NMDAR antibody-mediated autoimmune processes may be associated with TLE-AE, and 2) appropriate administration of ASD alone can improve clinical symptoms in mild cases of autoimmune epilepsy.
       
  • Extra operative intracranial EEG monitoring for epilepsy surgery in
           elderly patients

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Vineet Punia, Juan Bulacio, Jorge Gonzalez-Martinez, Ahmed Abdelkader, William Bingaman, Imad Najm, Andrey Stojic ObjectThe objective of the study is to investigate and report our experience with extra operative intracranial EEG monitoring for evaluation of epilepsy surgery among elderly (≥ 60 years) patients.MethodsAfter IRB approval, we searched our prospectively maintained epilepsy surgery database to find patients who underwent eiEEG at the age of 60 years or older. Electronic medical records were reviewed to extract clinical and surgery-related information. Patients who underwent resective epilepsy surgery after eiEEG and had at least 1 year of clinical follow-up were assessed for seizure outcome. Categorical and continuous variables were compared using Pearson chi-square and Student's t-test, respectively.ResultsA total of 21 patients, with 13 (62%) women, underwent eiEEG in our center at the age of 60 years or older. The mean age at time of implantation was 63.8 ± 2.7 years. Sub-dural grids (SDG) were implanted in five (24%) patients, whereas sixteen (76%) patients underwent stereo-EEG (SEEG) implantation. Median number of contacts in SDG were 106 (56–136) and depth electrodes in SEEG were 12 (9–14). There were 2 complications, including one mortality due to intracerebral hemorrhage. Sixteen (76%) patients underwent respective epilepsy surgery after eiEEG and eleven (69%) achieved Engel class I outcome on the last follow-up [mean follow-up duration of 2.7 (± 1.8) years].ConclusionWe noticed an increased utilization of eiEEG in elderly patients after the introduction of SEEG at our center. Overall, we found that eiEEG can help achieve good seizure outcomes in the elderly population. However, the one eiEEG-related mortality serves a word of caution about the potential risks in this population.
       
  • Working memory deficit in drug-resistant epilepsy with an amygdala lesion

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Keiko Usui, Kiyohito Terada, Naotaka Usui, Kazumi Matsuda, Akihiko Kondo, Takayasu Tottori, Jun Shinozaki, Takashi Nagamine, Yushi Inoue This study compared temporal lobe epilepsy (TLE) patients with amygdala lesion (AL) without hippocampal sclerosis (HS) (TLE-AL) with patients with TLE and HS without AL (TLE-HS). Both subtypes of TLE arose from the right hemisphere.The TLE-AL group exhibited a lower Working Memory Index (WMI) on the Wechsler Adult Intelligence Scale, third edition (WAIS-III), indicating that the amygdala in the right hemisphere is involved in memory-related function. [18F]fluorodeoxyglucose positron emission topography (FDG-PET) showed glucose hypometabolism limited to the right uncus for the TLE-AL group.The results suggest the importance of considering cognitive functions in the non-dominant hemisphere to prevent impairment after surgery.
       
  • Long-term use of methylphenidate in a boy with hypothalamic tumor,
           drug-resistant epilepsy and ADHD

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Dobrinko Socanski, Nebojsa Jovic, Harald Beneventi, Anita Herigstad
       
  • Sign and magnitude scaling properties of heart rate fluctuations following
           vagus nerve stimulation in a patient with drug-resistant epilepsy

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Eduardo Gutiérrez-Maldonado, Claudia Ivette Ledesma-Ramírez, Adriana Cristina Pliego-Carrillo, José Javier Reyes-Lagos Vagus nerve stimulation (VNS) therapy has been recently incorporated in Latin America as a treatment for drug-resistant epilepsy. In particular, it is known that linear analysis and fractal parameters of heart rate variability (HRV) are able to indirectly measure cardiac autonomic activity. This case report presents a 17-year-old female with drug-resistant epilepsy implanted with a VNS device. In order to explore cardiac autonomic changes due to VNS, linear and fractal HRV indices were calculated in the presence and absence of neurostimulation. Novel fractal scaling exponents from HRV analysis were obtained from this patient and from a healthy control subject. Our results indicate that fractal indices of HRV, such as short-term scaling parameters from magnitude and sign analyses seem to be sensitive to the presence or absence of VNS, being confirmed by linear classical methods. This study shows that VNS therapy increases the complexity of cardiac fluctuations in a patient with drug-resistant epilepsy, reflecting an augmented HRV non-linearity and a diminished anticorrelated pattern in heart rate fluctuations. A potential clinical use of these parameters includes the early identification of bradycardia, sudden unexpected death (SUDEP) risk and preoperative VNS approaches. Thus, the scaling and magnitude properties of HRV have potential importance as a non-invasive and easy method for adequate diagnostic/prognostic implications in epilepsy treatment.
       
  • Drug resistant epilepsy with mesial temporal sclerosis as possible late
           neurological complication in two AML survivors after stem cell
           transplantation

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Kwan-Ming Karen Yam, Wing-Kwan Alex Leung, Xian-Lun Zhu, Lai-Wah Eva Fung
       
  • Continuous monitoring devices and seizure patterns by glucose, time and
           lateralized seizure onset

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Katie M. Kinnear, Nicole M. Warner, Alan M. Haltiner, Michael J. Doherty ObjectivesTo investigate if glucose levels influence seizure patterns.Materials and methodsIn a patient with RNS/NeuroPace implanted bi-temporally and type 1 diabetes mellitus, seizure event times and onset locations were matched to continuous tissue glucose.ResultsLeft focal seizure (LFS, n = 22) glucoses averaged 169 mg/dL, while right focal seizure (RFS, n = 23) glucoses averaged 131 mg/dL (p = 0.03). LFS occurred at mean time 17:02 while RFS occurred at 04:23. LFS spread to the contralateral side (n = 19) more than RFS (n = 2).ConclusionSeizure onset laterality and spread vary with glucose and time of seizure.
       
  • Therapeutic augmentation of ketogenic diet with a sodium-glucose
           cotransporter 2 inhibitor in a super-refractory status epilepticus patient
           

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Joseph R. Blunck, Joseph W. Newman, Ronald K. Fields, John E. Croom BackgroundA ketogenic diet (KD) may have a role in treating patients in super-refractory status epilepticus (SRSE). Sodium-glucose cotransporter 2 (SGLT2) inhibitors have a risk of ketoacidosis that could facilitate induction of KD.Case summaryA 42-year-old with a history of drug resistant epilepsy developed SRSE requiring several pharmacological interventions during her hospital course including the initiation of KD that failed. SGLT2 inhibitor therapy was initiated in a successful attempt to augment ketone production.ConclusionSGLT2 inhibitors may have a therapeutic value in SRSE patients who cannot achieve ketosis with KD alone.
       
  • New onset syncopal events following vagus nerve stimulator implantation
           might be key to preventing vagus nerve stimulation-induced symptomatic
           bradycardia — A case report and review

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Hiroko Kato, Ayataka Fujimoto, Tohru Okanishi, Ryo Sugiura, Kentaro Ijima, Hideo Enoki PurposeTo identify risk factors for VNS-associated arrhythmia.MethodsA literature review identified 14 papers with 21 patients. We compared patients with VNS associated arrhythmia (arrhythmia group, n = 22) and patients without VNS associated arrhythmia (control group of our VNS implanted patients, n = 29).ResultsNew onset syncopal events following VNS placement were seen in the arrhythmia group (p 
       
  • Unusual seizure evolution: Focal-general-focal-general

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Christopher Smelick, Jeffrey W. Britton, William O. Tatum, Anteneh M. Feyissa Seizure types have been described that do not conform to traditional classification schemes. We present another unusual type characterized by focal onset with secondary generalization, that is followed immediately by continued focal activity that generalizes again without an intervening break. Better understanding of these seizure types may allow improved targeted therapies and help shed light on the mechanistic underpinnings of epilepsy.
       
  • Repetitive transcranial magnetic stimulation directed to a seizure focus
           localized by high-density EEG: A case report

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Robert Fisher, Jing Zhou, Adam Fogarty, Aditya Joshi, Matthew Markert, Gayle K. Deutsch, Mariel Velez We demonstrate feasibility of using high-density EEG to map a neocortical seizure focus in conjunction with delivery of magnetic therapy. Our patient had refractory seizures affecting the left leg. A five-day course of placebo stimulation followed a month later by active rTMS was directed to the mapped seizure dipole. Active rTMS resulted in reduced EEG spiking, and shortening of seizure duration compared to placebo. Seizure frequency, however, improved similarly in both placebo and active treatment stages. rTMS-evoked EEG potentials demonstrated that a negative peak at 40 ms - believed to represent GABAergic inhibition - was enhanced by stimulation.
       
  • Autoimmune encephalitis associated with two antibodies

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Nikolai Gil D. Reyes, Mario B. Prado, Christian Wilson R. Turalde, Marc Laurence L. Fernandez
       
  • Seizures in HIV: The case for special consideration

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Lilia Zaporojan, Patricia H. McNamara, Jennifer A. Williams, Colm Bergin, Janice Redmond, Colin P. Doherty PurposeThis study aimed to determine the rate, cause and management of seizures in the context of potential ART–ASD interactions in a cohort of HIV + individuals.MethodsRecords of 604 HIV + patients were reviewed and those reporting epilepsy/seizure diagnosis were further evaluated.ResultsThis cohort exhibited a seizure rate of 2.4%. HIV + patients treated for epilepsy displayed low serum ASD levels and failed to achieve seizure control. They were more likely to disengage from Neurology follow-up.ConclusionFor HIV + patients presenting with seizures/epilepsy the ASD prescription and the provision of supplementary support services needs to be carefully considered.
       
  • Lacosamide may improve cognition in patients with focal epilepsy: EpiTrack
           to compare cognitive side effects of lacosamide and carbamazepine

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Claudio Liguori, Francesca Izzi, Natalia Manfredi, Nicola Biagio Mercuri, Fabio Placidi Carbamazepine (CBZ) is a first generation anti-seizure drug, considered as first choice therapy in focal epilepsy but associated with cognitive side effects. Lacosamide (LCM) is a third-generation anti-seizure drug approved for treating focal epilepsy. This case series documented the comparable efficacy of LCM and CBZ as first add on treatments in patients affected by uncontrolled focal seizures. LCM showed an increase in EpiTrack scores, which measure cognitive abilities, at follow-up compared to CBZ. This preliminary data may represent the basis for future prospective studies aimed at comparing the long-term cognitive side effects of LCM and CBZ.
       
  • Seizure remission and improvement of neurological function in sialidosis
           with perampanel therapy

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Su-Ching Hu, Kun-Long Hung, Hui-Ju Chen, Wang-Tso Lee A 15-year-old boy experienced myoclonic seizures for 3 years. He initially had occasional myoclonus, gradually progressive ataxia, tremors, and psychomotor and speech regression developed. Eventually, he exhibited nearly continuous myoclonus. He received treatment of sodium valproate, levetiracetam, clobazam, and phenobarbital, without efficacy. A ketogenic diet also proved ineffective. Adjunctive therapy with 4 mg/day of perampanel was started and was gradually titrated to 10 mg/day. The remission of myoclonic seizures was achieved within one month. The patient's neurological and cognitive functions improved to a certain degree during the following 20 months. Sialidosis was confirmed by the mutations of NEU1 gene.
       
  • Teratoma-negative anti-NMDA receptor encephalitis presenting with a single
           generalized tonic–clonic seizure

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Andy Cheuk-Him Ng, Miljan Tripic, Seyed M. Mirsattari Herein, we describe a case report of anti-NMDA receptor encephalitis characterized by a single generalized tonic–clonic seizure and predominantly psychiatric symptoms, persisting long after EEG abnormalities had resolved. We discuss common presentations of anti-NMDA receptor encephalitis and advocate for the inclusion of this disease entity in the differential diagnosis of patients presenting with one generalized tonic–clonic seizure and prominent psychiatric symptoms.
       
  • Intracarotid amobarbital disrupts synchronous and nested oscillatory
           activity ipsilateral to injection

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): James J. Young, Joshua S. Friedman, Thomas J. Oxley, Christina Palmese, Fedor Panov, Saadi Ghatan, Johanna T. Fifi, Lara V. Marcuse The mechanism of amobarbital action during the intracarotid amobarbital procedure is poorly understood. We report a patient case who underwent IAP while implanted with bilateral stereo-EEG. We analyzed the spectral power, phase amplitude coupling, and cluster-phase group synchrony during the procedure. Delta and gamma power increased bilaterally. By contrast, phase amplitude coupling increased only ipsilateral to the injection. Similarly, 4–30 Hz cluster-phase group synchrony declines and gamma cluster-phase group synchrony increases only ipsilateral to the injection. These results suggest that a possible additional mechanism for amobarbital action in the IAP is by altering the precise timing of oscillatory activity.
       
  • Responsive neurostimulation for treatment of pediatric drug-resistant
           epilepsy

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Nilika S. Singhal, Adam L. Numis, Morgan B. Lee, Edward F. Chang, Joseph E. Sullivan, Kurtis I. Auguste, Vikram R. Rao Responsive neurostimulation for epilepsy involves an implanted device that delivers direct electrical brain stimulation in response to detection of incipient seizures. Responsive neurostimulation is a safe and effective treatment for adults with drug-resistant epilepsy, but although novel treatments are critically needed for younger patients, responsive neurostimulation is currently not approved for children with drug-resistant epilepsy. Here, we report a 16-year-old patient with seizures arising from eloquent cortex, who was successfully treated with responsive neurostimulation. This case highlights the potential utility of this therapy for pediatric patients and underscores the need for larger studies.
       
  • Recurrent seizures from chronic kratom use, an atypical herbal opioid

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): William O. Tatum, Tasneem F. Hasan, Erin E. Coonan, Christopher P. Smelick Kratom is an herbal compound that has been used as a recreational drug though is not regulated by the Food and Drug Administration. We report a 19-year-old male with recurrent seizures that developed during daily Kratom abuse as a self-treatment for anxiety. Following recurrent focal impaired awareness seizures in addition to generalized tonic–clonic seizures, he was begun on anti-seizure drugs. Seizures subsided after completing rehabilitation. Brain MRI at 29 months revealed bilaterally symmetric T1-hyperintensity in globus pallidus, subthalamic nuclei, and cerebral peduncles. Our case suggests Kratom abuse may be associated with structural brain lesions on MRI and symptomatic focal epilepsy.
       
  • Seizure frequency can be reduced by changing intracranial pressure: A case
           report in drug-resistant epilepsy

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Daiki Uchida, Ayataka Fujimoto, Tomohiro Yamazoe, Takamichi Yamamoto, Hideo Enoki A relationship between seizures and intracranial pressure (ICP) has been proposed, but not clearly identified. Whether changes in ICP can evoke seizures remains controversial. We report the case of a 23-year-old man who had undergone shunt surgery in childhood and later presented with focal impaired awareness seizures and behavior arrest. Seizures were uncontrolled despite 3 years of pharmacotherapy, but suddenly stopped after shunt removal. Our case supports the hypothesis that drug-resistant epilepsy can be influenced by changes in ICP. In particular, this case indicates that elevations in ICP may help reduce some seizures.
       
  • Drug-resistant epilepsy development following stem cell transplant and
           cyclosporine neurotoxicity induced seizures: Case report in an adult and
           analysis of reported cases in the literature

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Adam S. Vesole, Yasunori Nagahama, Mark A. Granner, Matthew A. Howard, Hiroto Kawasaki, Brian J. Dlouhy IntroductionDrug-resistant epilepsy (DRE) occurs in 20–30% of all patients who develop epilepsy and can occur from diverse causes. Cyclosporine-A (CSA) is an immunosuppressive drug utilized to prevent graft-versus-host disease (GvHD) in transplant patients and is known to cause neurotoxicity, including seizures. In some cases, however, patients can develop DRE. Only a limited number of cases have been reported in which DRE has developed after CSA exposure — all in children. Here we present a rare case of an adult developing DRE after post-transplant CSA neurotoxicity. In addition, we provide a comprehensive review and analysis of all reported cases in the literature.Case reportA 29-year-old man with Non-Hodgkin's Lymphoma underwent an allogenic hematopoietic stem cell transplant and experienced a CSA-induced seizure at 7.5 months' post-transplant. The patient was discontinued on CSA and began a low dose tacrolimus regimen. At 33 months' post-transplant, he had seizure recurrence and developed DRE. Imaging revealed right mesial temporal sclerosis (MTS) and video EEG localized ictal activity to the right anterior temporal lobe. He was successfully treated with a right anterior temporal lobectomy and amygdalohippocampectomy.Literature reviewSeven peer-reviewed studies described 15 patients who underwent transplantation with post-transplant CSA administration and subsequently developed DRE following an initial CSA-induced seizure. All 15 patients were children suggesting that young age is a risk factor for DRE after CSA-induced seizures. Initial CSA-induced seizures occurred at an average of 1.6 ± 1.1 months after transplant and seizure recurrence 9.2 ± 8.0 months after transplant. All reported CSA routes of administration (n = 6) were intravenous and 7 of 9 (78%) reported CSA blood levels above the therapeutic range. The incidence of MTS (40%) in these 15 patients was significantly higher than the incidence in the general DRE population (24%) and was most effectively treated via epilepsy surgery.ConclusionsThe use of cyclosporine for GvHD prophylaxis and treatment following transplantation may cause seizures and be associated with DRE. Although discontinuation and dose decrease of CSA often reverse adverse neurological events, initial CSA-induced seizures may be associated with MTS that and subsequent greater risk of DRE development.
       
  • Neurosurgical treatment of nonconvulsive status epilepticus due to focal
           cortical dysplasia

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Emin Timer, Saeid Charsouei, Nerses Bebek, Betül Baykan, Bilge Bilgiç, Pulat Akın Sabancı, Yavuz Aras, Nail İzgi, Candan Gürses We present a rare case of focal cortical dysplasia (FCD) and nonconvulsive status epilepticus (NCSE) treated successfully with early surgical intervention. Our case is a 9-year-old boy whose seizures, characterized by short episodes of loss of consciousness, appeared at the age of 7, and he showed progressive cognitive decline in the following years. NCSE was diagnosed, and his MRI revealed FCD in the left frontal region which was the same side as his EEG abnormality. Following lesionectomy, his NCSE disappeared and cognitive functions improved. Histopathologic analysis of the resected tissue revealed type-IIB FCD. This case illustrates the importance of early surgery to help restore cognitive functions by eliminating the clinical and electrophysiological features of NCSE.
       
  • Lacosamide-induced excessive laughing in a patient with
           Lennox–Gastaut syndrome

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Hussein Algahtani, Bader Shirah, Raghad Algahtani Lacosamide is one of the third-generation antiseizure drugs that block voltage-gated sodium channels by enhancing slow inactivation. The most common adverse effects of lacosamide include dizziness, headache, nausea, vomiting, diplopia, fatigue, and sedation. Less common side effects include memory impairment, weight gain, rash, and atrioventricular block. In this article, we describe a patient with Lennox–Gastaut syndrome who developed excessive laughing as a rare side effect of lacosamide with complete resolution after discontinuation of the medication. The present case illustrates that excessive laughing may occur as an adverse effect of lacosamide.
       
  • Successful use of pure cannabidiol for the treatment of super-refractory
           status epilepticus

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Rajsekar R. Rajaraman, Raman Sankar, Shaun A. Hussain We present the case of a child with long-standing, super-refractory status epilepticus (SRSE) who manifested prompt and complete resolution of SRSE upon exposure to pure cannabidiol. SRSE emerged in the context of remote suspected encephalitis with previously well-controlled epilepsy. We discuss the extent to which response may be specifically attributed to cannabidiol, with consideration and discussion of multiple potential drug–drug interactions. Based on this case, we propose that adjunctive cannabidiol be considered in the treatment of SRSE.
       
  • Ictal vomiting after cerebellar hemorrhage: A case report

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Shunsuke Nomura, Yuichi Kubota, Hidetoshi Nakamoto, Takakazu Kawamata Vomiting is a typical symptom of cerebellar hemorrhage. Usually only supportive care such as antiemetic drugs are available. A 76-year-old woman presented in a light coma. A head CT demonstrated right cerebellar hemorrhage and the hematoma was surgically evacuated. Her intractable vomiting started 3 weeks after surgery. Because her vomiting was unexplained, we checked her EEG, which demonstrated generalized periodic discharges. We diagnosed her with ictal vomiting. Anti-seizure medication was administered and vomiting was rapidly controlled. In conclusion, physicians must be aware that vomiting may rarely occur as a sign of seizures and status epilepticus.
       
  • Valproic acid as a monotherapy in drug-resistant methyl-CpG-binding
           protein 2 gene (MECP2) duplication-related epilepsy

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Meghna Rajaprakash, Julie Richer, Erick Sell Duplication of the methyl-CpG-binding protein 2 gene (MECP2) is a rare condition that results in epilepsy in half of the cases. Although this condition has been well characterized in the literature, there is a lack of research on MECP2 duplication-related epilepsy and its management.We present the case of an eleven-year old male with MECP2 duplication and epilepsy, who was resistant to polytherapy. The patient responded well to valproic acid (VPA) initially and upon re-challenge. This case report provides evidence for the use of VPA as an initial monotherapy for treatment of drug-resistant MECP2 duplication-related epilepsy.
       
  • Recurrent focal seizures as a feature of status epilepticus presenting as
           a peri-ictal water drinking

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Shuo Huang, Haifa Al-Abri, Alok Sachdeva, Ayham M. Alkhachroum, Stephanie Shatzman, Hans Lüders We report a case of focal status epilepticus (SE) associated with peri-ictal water drinking (PIWD) behavior in a nine-year-old left-handed boy with epilepsy. We reviewed prior cases of epileptic peri-ictal water drinking. Only one adult patient with status epilepticus and PIWD has been reported previously. This is the first reported case of PIWD SE in a pediatric patient with frontal lobe epilepsy. We found PIWD to have no lateralizing value.
       
  • Post-operative nonketotic hyperglycemic induced focal motor status
           epilepticus related to treatment with corticosteroids following standard
           anterior temporal lobectomy

    • Abstract: Publication date: 2018Source: Epilepsy & Behavior Case Reports, Volume 10Author(s): Andrew Zillgitt, Abdullah Alshammaa, Muhammad Salim Kahn, Sarah Madani, Salman Zahoor, Ellen L. Air
       
 
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