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Publisher: Elsevier   (Total: 3043 journals)

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Showing 1 - 200 of 3043 Journals sorted alphabetically
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 22, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 21, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 84, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 25, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 30, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 4)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 5, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 356, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 3)
Acta Biomaterialia     Hybrid Journal   (Followers: 25, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 1)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 234, SJR: 3.683, h-index: 202)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.615, h-index: 21)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 10, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription   (Followers: 1)
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 3, SJR: 0.311, h-index: 16)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 2)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 23, SJR: 1.365, h-index: 73)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 4)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 4, SJR: 0.383, h-index: 19)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 2)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 5, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 4, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 4)
Acute Pain     Full-text available via subscription   (Followers: 13)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 5)
Additive Manufacturing     Hybrid Journal   (Followers: 7, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 21)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 135, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 17, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 9, SJR: 0.299, h-index: 15)
Advances in Agronomy     Full-text available via subscription   (Followers: 15, SJR: 2.071, h-index: 82)
Advances in Anesthesia     Full-text available via subscription   (Followers: 25, SJR: 0.169, h-index: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 3)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 6, SJR: 1.054, h-index: 35)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 11, SJR: 0.801, h-index: 26)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 22, SJR: 1.286, h-index: 49)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
Advances in Botanical Research     Full-text available via subscription   (Followers: 3, SJR: 0.619, h-index: 48)
Advances in Cancer Research     Full-text available via subscription   (Followers: 25, SJR: 2.215, h-index: 78)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 0.9, h-index: 30)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 2.139, h-index: 42)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 26, SJR: 0.183, h-index: 23)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 9, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 29, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 16, SJR: 0.223, h-index: 22)
Advances in Dermatology     Full-text available via subscription   (Followers: 12)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 11)
Advances in Digestive Medicine     Open Access   (Followers: 6)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Ecological Research     Full-text available via subscription   (Followers: 41, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 25, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 7)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 41, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 3)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 50, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 16)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 22, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 0.497, h-index: 31)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 35, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 3, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6)
Advances in Life Course Research     Hybrid Journal   (Followers: 8, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 2)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Marine Biology     Full-text available via subscription   (Followers: 16, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 22)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 10)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 4)
Advances in Oncobiology     Full-text available via subscription   (Followers: 3)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 24, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 13)
Advances in Pharmacology     Full-text available via subscription   (Followers: 15, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 4)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 17)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 61)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.1, h-index: 2)
Advances in Space Research     Full-text available via subscription   (Followers: 355, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 8)
Advances in Surgery     Full-text available via subscription   (Followers: 7, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 30, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 17)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 44, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 5, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 326, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 5, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 8, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 406, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 16, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 30, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 39, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access  
Agriculture and Natural Resources     Open Access   (Followers: 1)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 54, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 5, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 11, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 8)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access  
Algal Research     Partially Free   (Followers: 8, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 4, SJR: 0.776, h-index: 35)
Alpha Omegan     Full-text available via subscription   (SJR: 0.121, h-index: 9)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 8, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 48, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 6)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 5)
American Heart J.     Hybrid Journal   (Followers: 49, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 47, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 39, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 8, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 15, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 31, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 25, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 32, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 45, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 231, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 58, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 5)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 25, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 26, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 22, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 34, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 5)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 57, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 11)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 4, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 37, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 168, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 8, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 11)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 1)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 22, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access  
Animal Behaviour     Hybrid Journal   (Followers: 161, SJR: 1.907, h-index: 126)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 5, SJR: 1.151, h-index: 83)
Animal Reproduction Science     Hybrid Journal   (Followers: 5, SJR: 0.711, h-index: 78)
Annales d'Endocrinologie     Full-text available via subscription   (Followers: 1, SJR: 0.394, h-index: 30)
Annales d'Urologie     Full-text available via subscription  
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (SJR: 0.177, h-index: 13)
Annales de Chirurgie de la Main et du Membre Supérieur     Full-text available via subscription  
Annales de Chirurgie Plastique Esthétique     Full-text available via subscription   (Followers: 2, SJR: 0.354, h-index: 22)
Annales de Chirurgie Vasculaire     Full-text available via subscription   (Followers: 1)

        1 2 3 4 5 6 7 8 | Last   [Sort by number of followers]   [Restore default list]

Journal Cover Actas Dermo-Sifiliograficas
  [4 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 0001-7310
   Published by Elsevier Homepage  [3043 journals]
  • Respuesta a omalizumab en 3 casos de urticaria solar
    • Authors: P. Rodríguez-Jiménez; P. Chicharro; A. Pérez-Plaza; D. de Argila
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): P. Rodríguez-Jiménez, P. Chicharro, A. Pérez-Plaza, D. de Argila
      Se presentan 3 pacientes con urticaria solar que o no habían respondido adecuadamente o presentaban limitaciones a los tratamientos de primera línea (antihistamínicos H1 a dosis altas o fototerapia), que fueron tratados con omalizumab. Dos de ellos mejoraron clínicamente con un aumento muy importante de la tolerancia a la luz, uno de ellos con clara mejoría de la calidad de vida. El otro paciente no mejoró y desarrolló una reacción local leve a la medicación inyectada. Omalizumab puede ser por tanto una alternativa terapéutica potencialmente útil y segura en urticarias solares graves no respondedoras al tratamiento convencional. We report 3 cases of solar urticaria in which there was no response or limited response to first-line treatments with high-dose H1 antihistamines or phototherapy. The patients were then treated with omalizumab. Symptoms improved in 2 patients, whose tolerance to sunlight increased considerably; quality of life clearly improved for 1 of these patients. The third experienced no improvement and developed a mild local reaction to the injected medication. We conclude that omalizumab may offer a potentially safe, useful alternative for patients with solar urticaria who do not respond to conventional therapy.

      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2016.08.011
       
  • El dermatólogo y el cáncer de piel. Consideraciones sobre el
           posicionamiento de la Sociedad Española de Oncología Médica
    • Authors: D. Moreno-Ramírez; E. Nagore; R. Botella-Estrada; G. Carretero; S. Puig; P. Redondo; M.A. Rodrígurez-Prieto; E. Samaniego; O. Sanmartín; J. Malvehy
      Pages: 704 - 707
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): D. Moreno-Ramírez, E. Nagore, R. Botella-Estrada, G. Carretero, S. Puig, P. Redondo, M.A. Rodrígurez-Prieto, E. Samaniego, O. Sanmartín, J. Malvehy


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.06.003
       
  • Novedades en inmunología del melanoma
    • Authors: I. Escandell; J.M. Martín; E. Jordá
      Pages: 708 - 720
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): I. Escandell, J.M. Martín, E. Jordá
      Desde la introducción de la inmunoterapia el tratamiento del melanoma ha sufrido una revolución, consiguiéndose cifras de supervivencia superiores a las que se alcanzaban con los tratamientos previos. Los fármacos inmunomoduladores disponibles actualmente van dirigidos principalmente frente a las moléculas de superficie CTLA-4 y PD-1, que ejercen un efecto inhibidor sobre la respuesta inmune antitumoral. Se trata de un tratamiento en pleno proceso de expansión, y la investigación se dirige hacia el descubrimiento de nuevas moléculas, las combinaciones de los fármacos disponibles o la identificación de biomarcadores que permitan seleccionar a los pacientes idóneos para cada terapia. Approaches to treating melanoma have changed radically since the introduction of immunotherapy, and survival figures are now higher than possible with earlier therapies. The immunomodulators currently available mainly block CTLA-4 (cytotoxicT lymphocyte-associated molecule-4) and PD-1 (programed cell death protein 1) translocated to the cell surface, where they inhibit the antitumor immune response. Treatments blocking these molecules are being more widely used. Research now seeks new molecular targets, the best combinations of available drugs, and biomarkers that can identify ideal candidates for each one.
      Graphical abstract image

      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.01.017
       
  • Nuevos avances de tratamiento inmunobiológico en el melanoma avanzado
    • Authors: M.C. Pérez Gago; O. Saavedra Santa Gadea; L. de la Cruz-Merino
      Pages: 721 - 728
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): M.C. Pérez Gago, O. Saavedra Santa Gadea, L. de la Cruz-Merino
      El melanoma irresecable localmente avanzado y metastásico es una situación clínica asociada a una elevada tasa de morbimortalidad. En los últimos años, sin embargo, han acontecido notables avances en el ámbito del tratamiento sistémico de esta enfermedad, con la irrupción de la terapia dirigida con inhibidores tirosincinasa que actúan bloqueando la vía de las MAPKinasas, y de la moderna inmunoterapia con anticuerpos monoclonales inmunomoduladores. En la presente revisión se realiza una actualización sobre los datos disponibles con los nuevos inmunoterápicos, así como un repaso del desarrollo clínico que ha permitido la aprobación para su uso en la práctica clínica habitual. Metastatic or locally advanced unresectable melanoma carries a high morbidity and mortality. However, notable advances have been made in recent years in the systemic treatment of this disease, with the appearance of targeted therapy using tyrosine kinase inhibitors that block the mitogen activated protein kinase pathway, and of modern immunotherapy with immune-modulating monoclonal antibodies. In this paper, we provide an update of available data on new immune therapies and we review the clinical development that led to their approval for use in routine clinical practice.

      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.01.016
       
  • Técnicas reconstructivas de elección por unidades estéticas
           faciales
    • Authors: F. Russo; M. Linares; M.E. Iglesias; J.L. Martínez-Amo; F. Cabo; J. Tercedor; R. Costa-Vieira; T. Toledo-Pastrana; J.M. Ródenas; V. Leis
      Pages: 729 - 737
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): F. Russo, M. Linares, M.E. Iglesias, J.L. Martínez-Amo, F. Cabo, J. Tercedor, R. Costa-Vieira, T. Toledo-Pastrana, J.M. Ródenas, V. Leis
      Introducción y objetivos Existe una enorme variedad de colgajos cutáneos empleados para la reparación de defectos quirúrgicos faciales tras la extirpación de tumores. El objetivo del estudio fue consensuar una guía práctica de los colgajos más útiles para cada una de las distintas unidades estéticas faciales. Material y métodos Estudio multicéntrico donde 10 dermatólogos de larga experiencia quirúrgica reconstructiva eligieron sus técnicas preferidas para cada unidad estética. La elección de estos colgajos se fundamentó en la experiencia personal de cada dermatólogo basándose en factores como la idoneidad de la técnica reconstructiva para ese defecto, el resultado estético final, la facilidad de ejecución y la baja probabilidad de complicaciones, entre otros. Eligieron 2 colgajos por orden de preferencia para cada subunidad estética y se le asignaron 10 puntos al primer colgajo y 5 al segundo. Resultados Con la suma obtenida de todas las opciones aportadas por los dermatólogos encuestados se obtuvo una relación de los 3 mejores colgajos para cada localización. Destacar la unanimidad de criterio por parte de la mayoría de los dermatólogos para técnicas reconstructivas como el colgajo glabelar para defectos de canto interno del ojo, el colgajo de avance bilateral en bandera o H para frente, el colgajo en puerta giratoria para concha auricular, el colgajo pangeniano para mejilla infraorbitaria, el colgajo de rotación O-Z para cuero cabelludo, el colgajo de Tenzel para párpado inferior y el colgajo en isla para labio superior. Conclusiones Los resultados de este estudio son de utilidad para ofrecer una guía práctica para la elección de las mejores técnicas reconstructivas en cada una de las distintas subunidades estéticas faciales. Background and objectives A broad range of skin flaps can be used to repair facial surgical defects after the excision of a tumor. The aim of our study was to develop a practical guideline covering the most useful skin grafts for each of the distinct facial cosmetic units. Material and methods This was a multicenter study in which 10 dermatologists with extensive experience in reconstructive surgery chose their preferred technique for each cosmetic unit. The choice of flaps was based on personal experience, taking into account factors such as suitability of the reconstruction technique for the specific defect, the final cosmetic result, surgical difficulty, and risk of complications. Each dermatologist proposed 2 flaps in order of preference for each cosmetic subunit. A score of 10 was given to the first flap and a score of 5 to the second. Results The total score obtained for each of the options proposed by the participating dermatologists was used to draw up a list of the 3 best grafts for each site. There was notable unanimity of criteria among most of the dermatologists for reconstructive techniques such as the glabellar flap for defects of the medial canthus of the eye, the bilateral advancement flag flap or H flap for the forehead, the rotary door flap for the auricle of the ear, the Mustarde flap for the infraorbital cheek, the O-Z rotation flap for the scalp, the Tenzel flap for the lower eyelid, and the island flap for the upper lip. Conclusions
      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.02.017
       
  • Factores de riesgo cardiovascular y grosor de la íntima media carotídea
           en una población colombiana con psoriasis
    • Authors: A. Argote; O. Mora-Hernández; L. Milena Aponte; D.I. Barrera-Chaparro; L.M. Muñoz-Ruiz; L. Giraldo-Mordecay; D. Camargo
      Pages: 738 - 745
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): A. Argote, O. Mora-Hernández, L. Milena Aponte, D.I. Barrera-Chaparro, L.M. Muñoz-Ruiz, L. Giraldo-Mordecay, D. Camargo
      Introducción y objetivo En la actualidad, se ha demostrado que la psoriasis presenta una importante asociación con síndrome metabólico y sus componentes. El objetivo de este estudio es determinar la prevalencia de los factores de riesgo cardiovascular y el engrosamiento de la íntima media carotídea en pacientes con psoriasis que consultan al servicio de dermatología de un hospital de 4.° nivel. Material y métodos Se realizó un estudio descriptivo de corte transversal en pacientes mayores de 18 años con diagnóstico de psoriasis, atendidos en la consulta de dermatología en el Hospital de San José, en Bogotá, Colombia. Entre marzo y agosto del 2015, se realizó un interrogatorio y un examen físico dirigido a la identificación de factores de riesgo cardiovascular, pruebas de laboratorio para determinar la presencia de síndrome metabólico y se practicó medición del grosor de la íntima media carotídea por ecografía. Resultados Fueron incluidos 40 pacientes con psoriasis. La prevalencia de factores de riesgo cardiovascular en este grupo de pacientes fue del 35% para hipertensión arterial, el 17,5% para dislipidemia, el 17,5% para tabaquismo y el 10% para diabetes mellitus tipo 2. El 12,5% de los sujetos tenía antecedente de infarto agudo de miocardio. Se encontró síndrome metabólico en 20 (50%) pacientes. La dislipidemia se reportó por bioquímica sanguínea en 32 (80%) pacientes. Según el score de Framingham, 11 pacientes (31,4%) tenían riesgo latente, 22 (62,8%) riesgo intermedio y 2 (5,7%) riesgo alto. En la evaluación de la carótida, se encontró una media del espesor intimal de 0,7 (DE 0,12) mm y engrosamiento en 6 pacientes (15,0%). Conclusiones Este estudio aporta información sobre la prevalencia alta de factores de riesgo cardiovascular en pacientes con psoriasis y orienta a un estricto abordaje clínico para el control del riesgo cardiovascular en esta población. Background and objectives Psoriasis is now known to have a clear association with metabolic syndrome and its components. The aim of our study was to determine the prevalence of cardiovascular risk factors (CVRFs) and increased carotid intima-media thickness in psoriasis patients seen in the dermatology department of a quaternary hospital. Material and methods This was a descriptive cross-sectional study of psoriasis patients aged over 18 years seen in the dermatology department of Hospital de San José in Bogota, Colombia, between March and August, 2015. Directed medical history and physical examination were performed to detect CVRFs, laboratory studies to exclude metabolic syndrome, and ultrasound examination to measure carotid intima-media thickness. Results Forty patients with psoriasis were included in the study. The prevalence of the distinct CVRFs was 35% for systemic hypertension, 17.5% for dyslipidemia, 17.5% for smoking, and 10% for type 2 diabetes mellitus. A history of acute myocardial infarction was detected in 12.5% of patients. Metabolic syndrome was found in 20 patients (50%), and blood biochemistry revealed dyslipidemia in 32 patients (80%). Based on the Framingham score, the cardiovascular risk was low in 11 patients (31.4%), intermediate in 22 (62.8%), and high in 2 (5.7%). Mean (SD) carotid intima-media thickness was 0.7 (0.12) mm, with thickening observed in 6 patients (15%).
      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.04.015
       
  • Plasma rico en plaquetas en el tratamiento del fotodaño cutáneo
           en las manos
    • Authors: J.O. Cabrera-Ramírez; A.G. Puebla-Mora; A. González-Ojeda; D. García-Martínez; J.A. Cortés-Lares; A.R. Márquez-Valdés; G.I. Contreras-Hernández; J. Bracamontes-Blanco; J.A. Saucedo Ortiz; C. Fuentes-Orozco
      Pages: 746 - 751
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): J.O. Cabrera-Ramírez, A.G. Puebla-Mora, A. González-Ojeda, D. García-Martínez, J.A. Cortés-Lares, A.R. Márquez-Valdés, G.I. Contreras-Hernández, J. Bracamontes-Blanco, J.A. Saucedo Ortiz, C. Fuentes-Orozco
      Introducción El plasma rico en plaquetas (PRP) aporta factores de crecimiento que inducen la síntesis de colágeno y otros componentes de la matriz extracelular, y estimula la activación de fibroblastos. El objetivo de este estudio es evaluar el efecto del PRP en el tratamiento del fotodaño en manos. Material y métodos Estudio de tipo experimental. Se incluyeron individuos con envejecimiento en el dorso de las manos, de tipo 3 en la escala de fotodaño de Glogau o de clase II de la clasificación de arrugas y elastosis de Fitzpatrick, entre agosto de 2012 y enero de 2013. Se aplicó PRP en la piel del dorso de las manos y se tomaron biopsias cutáneas antes y después del tratamiento para la comparación histológica. Resultados Se trataron 18 mujeres con una edad media de 47,9 ± 4,3 años. El análisis histológico demostró un incremento en el número de fibroblastos (p = 0,000), número de vasos (p = 0,000) y cantidad de colágeno (p = 0,27), representado como un cambio en la escala de clasificación de arrugas y elastosis de Fitzpatrick (p < 0,001) y en la escala de fotodaño de Glogau (p = 0,01). Conclusiones El PRP indujo una reducción en los signos y síntomas del envejecimiento cutáneo, con mejoría en las arrugas y elastosis. Background Platelet-rich plasma (PRP) provides growth factors that stimulate fibroblast activation and induce the synthesis of collagen and other components of the extracellular matrix. The objective of this study was to evaluate the effect of PRP in the treatment of photodamage of the skin of the hands. Material and methods Experimental study enrolling persons with photoaged skin on the dorsum of the hands (Glogau photoaging scale, type III, or Fitzpatrick wrinkle classification, type II) were included between August 2012 and January 2013. A histological comparison was made of skin biopsies taken before and after the application of PRP to the skin of the dorsum of the hands. Results The mean (SD) age of the 18 women enrolled was 47.9 (4.3) years. Histological analysis showed an increase in the number of fibroblasts (P<.001), number of vessels (P<.001), and collagen density (P=.27). These changes produced significant improvements in the Fitzpatrick wrinkle and elastosis scale (P<.001) and in the Glogau photoaging scale (P=.01). Conclusions PRP induced a reduction in the manifestations of skin aging, including an improvement in wrinkles and elastosis.
      Graphical abstract image

      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.04.006
       
  • Successful Short Desensitization Treatment Protocol with Narrowband UVB
           Phototherapy (TL-01) in Polymorphic Light Eruption
    • Authors: A. Combalia; C. Fernández-Sartorio; X. Fustà; D. Morgado-Carrasco; S. Podlipnik; P. Aguilera
      Pages: 752 - 757
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): A. Combalia, C. Fernández-Sartorio, X. Fustà, D. Morgado-Carrasco, S. Podlipnik, P. Aguilera
      Introduction Polymorphic light eruption (PLE) is a common idiopathic photodermatosis that typically presents with pruritic papular or papulovesicular lesions on sun-exposed skin between spring and autumn. In many subjects PLE is mild, and can usually be prevented by the use of broad-spectrum topical sunscreens and a gradual increase in sunlight exposure. However, in some individuals, sunlight exposure results in florid PLE and they often benefit from prophylactic desensitization treatment using phototherapy in early spring, an artificial method that induces a “hardening” phenomenon. Objective To describe and evaluate the efficacy of a short desensitization protocol, based on a one-month-treatment, administered twice a week with narrow band UVB in subjects with severe polymorphic light eruption (PLE). Methods A retrospective, open planned and non-randomized study to assess the efficacy of UVB phototherapy in prevention of polymorphic light eruption. Results Fifteen subjects diagnosed with severe PLE were treated with the standard protocol in our Photobiology Unit between 2014 and 2015. The effect of hardening was sustained during follow up in 87.5% of desensitization treatments. A statistically significant association (p <0.05) between the years of duration of the PLE and the response to treatment was found. Conclusions The effect of hardening was maintained in the vast majority of subjects, obtaining a good benefit with no PLE episodes during all the summer. We demonstrate that our standard protocol is effective, and produces a successful outcome for the majority of PLE subjects. Our protocol is shorter than those currently applied, being favourable both for the patient and the physician.
      Graphical abstract image

      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.04.004
       
  • Conservantes en productos de higiene y cosméticos, medicamentos tópicos
           y productos de limpieza doméstica en España
    • Authors: María Antonia Pastor-Nieto; Francisco Alcántara-Nicolás; Virginia Melgar-Molero; Raquel Pérez-Mesonero; Aránzazu Vergara-Sánchez; Adriana Martín-Fuentes; Patricia González-Muñoz; Ester de Eusebio-Murillo
      Pages: 758 - 770
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): María Antonia Pastor-Nieto, Francisco Alcántara-Nicolás, Virginia Melgar-Molero, Raquel Pérez-Mesonero, Aránzazu Vergara-Sánchez, Adriana Martín-Fuentes, Patricia González-Muñoz, Ester de Eusebio-Murillo
      Introducción Los conservantes se agregan a cosméticos, limpiadores domésticos y otros productos industriales para impedir el crecimiento de microorganismos. Desafortunadamente, pueden sensibilizar a usuarios expuestos. Material y métodos Entre enero y junio de 2015 se analizaron las listas de los ingredientes de 2.300 productos de venta en España: 1.093 dermocosméticos, 458 productos de higiene, cosméticos y limpiadores domésticos de venta en supermercados, 636 medicamentos tópicos y 113 cosméticos de herbolario. Se evaluó la distribución de una amplia variedad de conservantes en las distintas categorías de productos. Resultados Conservantes tales como el fenoxietanol, el ácido cítrico, el benzoato sódico y el sorbato potásico estuvieron ampliamente representados en todas las categorías de cosméticos. Se detectaron parabenos en el 16,1% de los dermocosméticos, el 14,45% de los cosméticos de supermercado, el 0,88% de los cosméticos de herbolario, el 5,18% de los medicamentos tópicos y ningún producto de limpieza. Se objetivaron isotiazolinonas en el 2,56% de los dermocosméticos, el 18% de los cosméticos de supermercado, el 7,9% de los cosméticos de herbolario, el 63,63% de los limpiadores domésticos y en ningún medicamento tópico. Contenían liberadores de formaldehído el 5,76% de los dermocosméticos, el 6,42% de los cosméticos de supermercado, el 7,96% de los cosméticos de herbolario, el 3,93% de los medicamentos tópicos y el 16,74% de los limpiadores. Conclusiones La evaluación de la frecuencia de los conservantes en los productos de nuestro entorno permite una estimación indirecta del grado de exposición a cada uno de ellos. Se precisa impulsar medidas que conduzcan a una restricción en el uso de los conservantes más problemáticos. Introduction Preservatives are added to cosmetic, household cleaning, and other industrial products to prevent the growth of microorganisms. Unfortunately, exposure to these substances can cause sensitization. Material and methods Between January and June 2015, we analyzed the ingredients of 2300 products commercially available in Spain to identify the frequency of a wide variety of preservatives in different product categories. We analyzed 1093 skin care and cosmetic products sold exclusively in pharmacies (dermocosmetics), 458 household cleaning and personal hygiene and cosmetic products sold in supermarkets, 636 topical medications, and 113 cosmetic products sold in a herbal shop. Results Phenoxyethanol, citric acid, sodium benzoate, and potassium sorbate were very common in all the cosmetic product categories. Parabens were present in 16.1% of dermocosmetic products, 14.45% of cosmetic products available in supermarkets, 0.88% of cosmetic products available in the herbal shop, 5.18% of topical medications, and in none of the cleaning products. Isothiazolinones were identified in 2.56% of dermocosmetic products, 18% of cosmetic products in supermarkets, 7.9% of cosmetic products in the herbal shop, 63.63% of household cleaners, and in none of the topical medications. Formaldehyde releasers were detected in 5.76% of dermocosmetic products, 6.42% of cosmetic products sold in supermarkets, 7.96% of cosmetic products sold in the herbal shop, 3.93% of topical medications, and 16.74% of household cleaners.
      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.04.003
       
  • Tumoración excrecente en sien izquierda
    • Authors: E. Varas-Meis; M.M. Otero-Rivas; M.Á. Rodriguez-Prieto
      Pages: 771 - 772
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): E. Varas-Meis, M.M. Otero-Rivas, M.Á. Rodriguez-Prieto


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2016.02.026
       
  • Hiperqueratosis folicular filiforme en la cara
    • Authors: J. Ruiz-Rivero; M. Campos Domíngez; V. Parra Blanco; R. Suárez-Fernández
      Pages: 773 - 774
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): J. Ruiz-Rivero, M. Campos Domíngez, V. Parra Blanco, R. Suárez-Fernández


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2016.02.025
       
  • FR - Nevus melanocíticos eruptivos asociados a medicamentos
    • Authors: P. García-Montero; J.F. Millán-Cayetano; C. García-Harana; J. del Boz
      Pages: 775 - 776
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): P. García-Montero, J.F. Millán-Cayetano, C. García-Harana, J. del Boz


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2016.12.024
       
  • Lesión nodular erosiva en el pabellón auricular de una
           adolescente
    • Authors: E. Garcia-Zamora; E. Naz-Villalba; F. Pinedo-Moraleda
      First page: 777
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): E. Garcia-Zamora, E. Naz-Villalba, F. Pinedo-Moraleda


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2016.10.004
       
  • Dissecting cellulitis of the scalp
    • Authors: A. Ortiz-Prieto; A. Pulpillo-Ruiz; J. Conejo-Mir
      First page: 778
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): A. Ortiz-Prieto, A. Pulpillo-Ruiz, J. Conejo-Mir


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2016.04.025
       
  • Dermoscopy of Erythromelanosis Follicularis Faciei et Colli
    • Authors: E. Errichetti; S. Pizzolitto; G. Stinco
      Pages: 779 - 781
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): E. Errichetti, S. Pizzolitto, G. Stinco


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.04.016
       
  • Hyperkeratotic lesions on legs
    • Authors: J.M. Sánchez Sánchez; J. Molinero Caturla; J.R. Ferreres Riera; R.M. Penín Mosquera
      Pages: 781 - 782
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): J.M. Sánchez Sánchez, J. Molinero Caturla, J.R. Ferreres Riera, R.M. Penín Mosquera


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.05.001
       
  • Dermatitis granulomatosa postherpética en un paciente tratado con
           nivolumab
    • Authors: P. Martín-Carrasco; C. Pérez-Ruiz; T. de Zulueta-Dorado; J. Conejo-Mir
      Pages: 783 - 784
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): P. Martín-Carrasco, C. Pérez-Ruiz, T. de Zulueta-Dorado, J. Conejo-Mir


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.02.016
       
  • Melanoma amelanótico subungueal simulando granuloma telangiectásico.
           Correlación clínica, histológico y radiológica
    • Authors: M. Silva-Feistner; E. Ortiz; S. Alvarez-Véliz; X. Wortsman
      Pages: 785 - 787
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): M. Silva-Feistner, E. Ortiz, S. Alvarez-Véliz, X. Wortsman


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.03.008
       
  • Panarteritis nudosa con patrón de respuesta inflamatoria
           sistémica: respuesta a anti-TNF
    • Authors: F. Tous-Romero; E. Rodríguez-Almaraz; J.L. Rodríguez-Peralto; C. Postigo-Llorente
      Pages: 787 - 790
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): F. Tous-Romero, E. Rodríguez-Almaraz, J.L. Rodríguez-Peralto, C. Postigo-Llorente


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.01.021
       
  • Liquen plano palmoplantar: espectro de manifestaciones clínicas en un
           paciente
    • Authors: S. Burillo-Martínez; F. Tous-Romero; J.L. Rodríguez-Peralto; C. Postigo-Llorente
      Pages: 790 - 792
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): S. Burillo-Martínez, F. Tous-Romero, J.L. Rodríguez-Peralto, C. Postigo-Llorente


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.01.019
       
  • Ecografía del síndrome linfoproliferativo primario cutáneo T CD4+ de
           célula pequeña/mediana
    • Authors: E. Rodríguez-Lomba; I. Molina-López; A. Pulido-Pérez; C. Ciudad-Blanco
      Pages: 792 - 794
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): E. Rodríguez-Lomba, I. Molina-López, A. Pulido-Pérez, C. Ciudad-Blanco


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2016.11.022
       
  • Merece la pena hacerse miembro de la European Academy of Dermatology and
           Venereology (EADV)
    • Authors: E. Nagore; L. Puig
      First page: 605
      Abstract: Publication date: September 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 7
      Author(s): E. Nagore, L. Puig


      PubDate: 2017-09-05T08:43:46Z
      DOI: 10.1016/j.ad.2017.07.007
       
  • Ivermectina oral: recuperando un fármaco para el tratamiento de la
           escabiosis
    • Authors: G. Blasco Morente
      First page: 606
      Abstract: Publication date: September 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 7
      Author(s): G. Blasco Morente


      PubDate: 2017-09-05T08:43:46Z
      DOI: 10.1016/j.ad.2017.04.008
       
  • Variabilidad en la toma de decisiones terapéuticas. A propósito de la
           evaluación de la fiabilidad de una herramienta TIC
    • Authors: F. Rivas Ruiz
      First page: 607
      Abstract: Publication date: September 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 7
      Author(s): F. Rivas Ruiz


      PubDate: 2017-09-05T08:43:46Z
      DOI: 10.1016/j.ad.2017.04.009
       
  • Facilitando el cierre de defectos faciales con puntos enterrados
    • Authors: G. Romero; P. Cortina
      Pages: 607 - 608
      Abstract: Publication date: September 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 7
      Author(s): G. Romero, P. Cortina


      PubDate: 2017-09-05T08:43:46Z
      DOI: 10.1016/j.ad.2017.03.010
       
  • Placa facial y nódulos en cuero cabelludo
    • Authors: M.Á. Flores-Terry; M.P. Cortina de la Calle; C. Ramos-Rodríguez; F. Martín-Dávila
      Abstract: Publication date: Available online 12 October 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M.Á. Flores-Terry, M.P. Cortina de la Calle, C. Ramos-Rodríguez, F. Martín-Dávila


      PubDate: 2017-10-16T22:27:56Z
      DOI: 10.1016/j.ad.2016.12.026
       
  • Dermatitis de contacto alérgica por regiones anatómicas. Claves
           diagnósticas
    • Authors: E. Rozas-Muñoz; D. Gamé; E. Serra-Baldrich
      Abstract: Publication date: Available online 12 October 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): E. Rozas-Muñoz, D. Gamé, E. Serra-Baldrich
      La dermatitis de contacto alérgica (DCA) es una enfermedad frecuente en la práctica clínica diaria, con una prevalencia que ha aumentado en los últimos años. Clínicamente se caracteriza por grados variables de eritema, vesiculación, descamación y liquenificación, signos que también están presentes en otros procesos eccematosos. Las pruebas epicutáneas constituyen la principal herramienta diagnóstica para confirmar una DCA, sin embargo, su correcta interpretación requiere de una correcta correlación entre la anamnesis (historial de exposición) y el examen físico. En este artículo se describen de forma práctica y didáctica los patrones clínicos más frecuentes de DCA dependiendo de su localización. El conocimiento de estos patrones no solo ayudará al clínico en el diagnóstico diferencial, sino que también le permitirá sospechar el posible alérgeno y su forma de aplicación. Allergic contact dermatitis (ACD) is a common disease in daily clinical practice, and its prevalence has increased in recent years. It is characterized clinically by varying degrees of erythema, vesiculation, flaking, and lichenification, though these signs can also be present in other eczematous diseases. Patch testing is the main diagnostic tool to confirm ACD, but its accurate interpretation requires correct correlation with the medical history (details of exposure) and physical examination. We provide a practical and instructive description of the most common clinical patters of ACD depending on the area affected. Knowledge of these patterns will not only help the clinician reach the diagnosis but will suggest possible allergens and forms of contact.
      Graphical abstract image

      PubDate: 2017-10-16T22:27:56Z
      DOI: 10.1016/j.ad.2017.05.011
       
  • Reply To: The Possible Combined Action of Different Trigger Agents in
           Rosacea
    • Abstract: Publication date: Available online 12 October 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): Á. Hernández-Martín


      PubDate: 2017-10-16T22:27:56Z
       
  • The Possible Combined Action of Different Trigger Agents in Rosacea
    • Authors: G. Ciccarese; A. Parodi; A. Rebora; F. Drago
      Abstract: Publication date: Available online 12 October 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): G. Ciccarese, A. Parodi, A. Rebora, F. Drago


      PubDate: 2017-10-16T22:27:56Z
      DOI: 10.1016/j.ad.2017.07.013
       
  • Morfea y liquen escleroatrófico extragenital generalizados tras
           vacuna antigripal
    • Authors: Requena Hidalgo; Vivanco Allende
      Abstract: Publication date: Available online 10 October 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): S. Requena López, Y. Hidalgo García, S. Gómez Díez, B. Vivanco Allende


      PubDate: 2017-10-10T19:47:29Z
       
  • Prevalence of Actinic Keratosis in Different Regions of Spain: The EPIQA
           Study
    • Authors: Lera-Imbuluzqueta M.J.; Plazas-Fernandez
      Abstract: Publication date: Available online 10 October 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): C. Ferrándiz-Pulido, M. Lera-Imbuluzqueta, C. Ferrándiz, M.J. Plazas-Fernandez


      PubDate: 2017-10-10T19:47:29Z
       
  • Nevus azul subungueal
    • Authors: Fachal L.C.; Allegue
      Abstract: Publication date: Available online 7 October 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): C. Fachal, L.C. Pérez-Pérez, F. Allegue, S. Calviño


      PubDate: 2017-10-10T19:47:29Z
       
  • Tratamiento de las neoplasias anexiales cutáneas malignas
    • Authors: Requena
      Abstract: Publication date: Available online 6 October 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): C. Bernárdez, L. Requena
      Las neoplasias anexiales cutáneas malignas constituyen un grupo de carcinomas poco frecuentes, habitualmente de bajo grado de malignidad, que muestran diferenciación folicular, sebácea, apocrina o ecrina o una combinación de las 3 primeras. Clínicamente suelen ser neoplasias con características poco distintivas, siendo necesaria una biopsia que permitirá establecer el tipo de diferenciación y el diagnóstico definitivo. Al tratarse de una enfermedad poco frecuente, no existe un claro consenso sobre el tratamiento más eficaz. En la mayoría de casos se considera la microcirugía de Mohs como la opción más efectiva para prevenir recidivas. La radioterapia y quimioterapia han sido escasamente estudiadas y solo se han mostrado eficaces en escasas ocasiones. Malignant cutaneous adnexal neoplasms form a group of rare, typically low-grade-malignancy carcinomas with follicular, sebaceous, apocrine, or eccrine differentiation or a combination of the first 3 subtypes. Their clinical presentation is usually unremarkable, and biopsy is required to establish the differentiation subtype and the definitive diagnosis. Due to their rarity, no clear consensus has been reached on which treatment is most effective. Mohs micrographic surgery is considered to be the best option to prevent recurrence in the majority of patients. Radiotherapy and chemotherapy have been studied in very few cases and have rarely been shown to be effective.
      Graphical abstract image

      PubDate: 2017-10-10T19:47:29Z
       
  • La dermatología pediátrica española en el punto de mira
           internacional
    • Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): A. Martín-Santiago


      PubDate: 2017-10-03T04:22:44Z
       
  • Riesgo cardiovascular en psoriasis
    • Authors: M.P.
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): M.P. González García


      PubDate: 2017-10-03T04:22:44Z
       
  • Sobre el uso de la fototerapia en el manejo de las fotodermatosis
    • Authors: Argila
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): D. de Argila Fernández-Durán


      PubDate: 2017-10-03T04:22:44Z
       
  • Conocimiento de conservantes: crucial en Dermatología
    • Authors: Tercedor
      Abstract: Publication date: October 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 8
      Author(s): J. Tercedor


      PubDate: 2017-10-03T04:22:44Z
       
  • Estudio observacional de seguridad, prospectivo y unicéntrico para
           determinar la capacidad alergogénica de Mercromina Film® y otros
           antisépticos de uso común en pacientes con dermatitis de contacto
    • Authors: S. Baltà Cruz; N. Moreno Ribera; M.T. Estrach Panella
      Abstract: Publication date: Available online 30 September 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): S. Baltà Cruz, N. Moreno Ribera, M.T. Estrach Panella
      Introducción Pese al uso tan extendido de la Mercromina Film® y otros antisépticos de uso tópico, estos no se encuentran incluidos en la serie estándar española del Grupo Español de Investigación en Dermatitis de Contacto y Alergia Cutánea, realizada ante sospecha de dermatitis alérgica de contacto. Además, no existen estudios recientes sobre capacidad alergogénica de la merbromina, motivo por el que se plantea la presente investigación. Objetivo Determinar la capacidad alergénica de la merbromina y compararla con la de los otros antisépticos de uso tópico frecuentemente utilizados en la práctica clínica, entre los que se incluye la povidona iodada, clorhexidina y eosina. Material y métodos Estudio observacional de seguridad, prospectivo y unicéntrico realizado en 105 pacientes con sospecha de dermatitis alérgica de contacto que acudieron a la consulta del departamento de dermatología. Resultados El 1,9% de los participantes presentó dermatitis alérgica de contacto a la merbromina. El 12,4% de los pacientes presentó sensibilización ante la povidona iodada. Las diferencias entre el porcentaje de pacientes que presentó dermatitis alérgica de contacto a Betadine® solución dérmica respecto al resto de antisépticos fueron estadísticamente significativas (prueba de McNemar; p<0,05). No se registraron efectos adversos con ninguno de los antisépticos en estudio. Conclusiones Mercromina Film ha demostrado una muy baja capacidad alergénica en la prueba de patch test. Cuando se comparan con otros antisépticos tópicos, la mayor capacidad alergénica se encontró con la povidona iodada. Introduction Although Mercromina Film and other topical antiseptics are widely used, they are not included in the standard series recommended by the Spanish Contact Dermatitis and Skin Allergy Research Group for testing suspected allergic contact dermatitis (ACD). Furthermore, no recent studies have investigated the allergenic potential of merbromin. Objective To determine the allergenic potential of merbromin and compare it with that of other topical antiseptics widely used in clinical practice, including povidone-iodine, chlorhexidine, and eosin. Material and methods Prospective single-center observational safety study of 105 patients with suspected ACD seen at the dermatology department of our hospital. Results Of the 105 patients studied, 1.9% had a positive patch test to merbromin and 12.4% were sensitized to povidone-iodine. The differences in the proportion of patients with ACD to Betadine Solución Dérmica (povidone-iodine) compared with the rest of the antiseptics was statistically significant (McNemar test, P<.05). No adverse reactions were observed in any of the patients.
      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.06.013
       
  • Colgajo de keystone tipo i
    • Authors: H.A. Cocunubo-Blanco; A. Pérez-Bustillo; E. Manrrique; M.Á. Rodríguez-Prieto
      Abstract: Publication date: Available online 28 September 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): H.A. Cocunubo-Blanco, A. Pérez-Bustillo, E. Manrrique, M.Á. Rodríguez-Prieto


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.05.015
       
  • Sensibilización alérgica a isotiazolinonas en pacientes remitidos a
           estudio fotobiológico
    • Authors: M. Giácaman-von der Weth; A. Pérez-Ferriols; C. Sierra-Talamantes; V. Zaragoza-Ninet
      Abstract: Publication date: Available online 28 September 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M. Giácaman-von der Weth, A. Pérez-Ferriols, C. Sierra-Talamantes, V. Zaragoza-Ninet


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.02.029
       
  • Tumor fibroso solitario cutáneo: una neoplasia fusocelular con una
           inmunohistoquímica particular
    • Authors: J. Santos-Juanes; B. García-García; Y. Hidalgo; B. Vivanco
      Abstract: Publication date: Available online 28 September 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): J. Santos-Juanes, B. García-García, Y. Hidalgo, B. Vivanco


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.03.019
       
  • Dermatitis de contacto a antisépticos tópicos. ¿Qué posición ocupa la
           Mercromina Film®'
    • Authors: F.J.
      Abstract: Publication date: Available online 28 September 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): F.J. Navarro-Triviño


      PubDate: 2017-10-03T04:22:44Z
       
  • Malignant Blue Nevus: A Challenge for Dermatologists and
           Dermatopathologists
    • Authors: T. Toledo-Pastrana; I. Rodríguez Pérez; P. Eguino Gorrochategui
      Abstract: Publication date: Available online 28 September 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): T. Toledo-Pastrana, I. Rodríguez Pérez, P. Eguino Gorrochategui


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.02.031
       
  • Tumor de rápido crecimiento en el párpado
    • Authors: C.A. Morales-Cardona; C. Rodríguez-Zakzuk; A. Téllez-Lozada
      Abstract: Publication date: Available online 28 September 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): C.A. Morales-Cardona, C. Rodríguez-Zakzuk, A. Téllez-Lozada


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2016.10.024
       
  • Úlcera dolorosa en paciente de raza negra
    • Authors: I. Latour-Álvarez; M. Arteaga-Henriquez; A. de Andrés-del Rosario
      Abstract: Publication date: Available online 28 September 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): I. Latour-Álvarez, M. Arteaga-Henriquez, A. de Andrés-del Rosario


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2016.10.025
       
  • Ampliando el espectro ecográfico de las anomalías vasculares
    • Authors: Alfageme
      Abstract: Publication date: Available online 28 September 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): F. Alfageme


      PubDate: 2017-10-03T04:22:44Z
       
  • Placas anulares bilaterales en manos y antebrazos
    • Authors: E. Rozas-Muñoz; J.F. Mir-Bonafé; E. Serra-Baldrich
      Abstract: Publication date: Available online 28 September 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): E. Rozas-Muñoz, J.F. Mir-Bonafé, E. Serra-Baldrich


      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.04.022
       
  • Manejo práctico de inmunosupresores en dermatología
    • Authors: V.M. Leis-Dosil; I. Prats-Caelles
      Abstract: Publication date: Available online 28 September 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): V.M. Leis-Dosil, I. Prats-Caelles
      Las enfermedades inflamatorias y autoinmunes constituyen un desafío terapéutico por frecuencia y complejidad. Su tratamiento se basa en la inmunosupresión del paciente con glucocorticoides, inmunosupresores ahorradores de corticoides y fármacos biológicos, siendo imprescindible por tanto conocer su manejo. Cuando se va a pautar un inmunosupresor es necesario realizar un estudio previo para detectar contraindicaciones, infecciones latentes o determinar la dosis más adecuada del fármaco. Durante el tratamiento se deben realizar controles periódicos para detectar efectos secundarios. Cada fármaco tiene un tiempo de inicio de acción que es preciso conocer, así como una duración o dosis acumulada máxima recomendada. Los dermatólogos estamos habituados al uso estos fármacos inmunosupresores, pero es necesario tener claras las pautas y los controles necesarios con cada uno, para disminuir la variabilidad y evitar efectos adversos potencialmente graves. The treatment of inflammatory and autoimmune diseases is challenging because of their frequency and complexity. Treatment of these diseases is based on the suppression of the patient's immune system using corticosteroids, corticosteroid-sparing immunosuppressive agents, and biologic drugs, making an understanding of the management of immunosuppressive therapy essential. Before an immunosuppressive agent is prescribed, a study must be carried out to identify contraindications, detect latent infections, and determine the most appropriate dose. During treatment, regular monitoring is required to detect adverse effects. The clinician must be familiar with the time lag between start of treatment and onset of the immunosuppressive effect as well as the maximum recommended duration of treatment and cumulative dose for each drug. As dermatologists we are accustomed to using these immunosuppressive agents, but we should have a good knowledge of the guidelines for their use and the monitoring required in each case if we are to reduce variability and avoid potentially serious adverse effects.

      PubDate: 2017-10-03T04:22:44Z
      DOI: 10.1016/j.ad.2017.05.005
       
  • La resonancia magnética muscular y el tratamiento agresivo precoz, claves
           en la dermatomiositis juvenil
    • Authors: O. Corral-Magaña; A.F. Bauzá-Alonso; M.M. Escudero-Góngora; L. Lacruz; A. Martín-Santiago
      Abstract: Publication date: Available online 12 September 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): O. Corral-Magaña, A.F. Bauzá-Alonso, M.M. Escudero-Góngora, L. Lacruz, A. Martín-Santiago
      La dermatomiositis juvenil es una conectivopatía sistémica infrecuente de aparición en la edad pediátrica. Clínicamente se caracteriza por la presencia de debilidad muscular proximal con afectación cutánea característica. El diagnóstico de la enfermedad se realiza mediante los criterios de Bohan y Peter, si bien recientemente numerosos autores están sustituyendo la realización de biopsia muscular por la resonancia magnética muscular (RMM) para el diagnóstico y seguimiento de la enfermedad. En fases crónicas de la enfermedad, y sin un tratamiento precoz intensivo, pueden aparecer complicaciones como la calcinosis cutánea o la lipoatrofia, por lo que el reconocimiento temprano de la enfermedad es clave en el manejo. Presentamos una serie de 5 pacientes diagnosticados de dermatomiositis juvenil mediante RMM sin realizarse biopsia muscular y tratados de forma temprana. Resaltamos la utilidad de la RMM en el diagnóstico de la enfermedad muscular y la importancia de instaurar el tratamiento de forma precoz e intensiva para prevenir las complicaciones. Juvenile dermatomyositis is a rare systemic connective tissue disease with onset during childhood. It presents clinically with proximal muscle weakness and characteristic skin involvement. Diagnosis is based on the Bohan and Peter criteria, though many authors are now substituting biopsy with muscle magnetic resonance imaging (MRI) for both diagnosis and follow-up. Without intensive early treatment, complications such as calcinosis cutis and lipodystrophy can develop in the chronic phases of the disease. Early recognition is therefore key to management. We present a series of 5 patients who were diagnosed with Juvenile dermatomyositis on muscle MRI without undergoing muscle biopsy and who received early treatment. We draw attention to the usefulness of muscle MRI for the diagnosis of muscle involvement and to the importance of early initiation of intensive treatment to prevent complications.
      Graphical abstract image

      PubDate: 2017-09-15T16:20:24Z
      DOI: 10.1016/j.ad.2017.07.003
       
  • Otras caras de la enfermedad de Darier
    • Authors: del Rio
      Abstract: Publication date: September 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 7
      Author(s): E. del Rio


      PubDate: 2017-09-05T08:43:46Z
       
 
 
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