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Publisher: Elsevier   (Total: 3043 journals)

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Showing 1 - 200 of 3043 Journals sorted alphabetically
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 20, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 18, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 83, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 23, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 27, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 4)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 5, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 333, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 3)
Acta Biomaterialia     Hybrid Journal   (Followers: 25, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 1)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 225, SJR: 3.683, h-index: 202)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.615, h-index: 21)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 9, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription   (Followers: 1)
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 3, SJR: 0.311, h-index: 16)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 2)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 23, SJR: 1.365, h-index: 73)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 4)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 4, SJR: 0.383, h-index: 19)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 2)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 5, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 4, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 3)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 5)
Additive Manufacturing     Hybrid Journal   (Followers: 8, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 20)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 134, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 16, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 9, SJR: 0.299, h-index: 15)
Advances in Agronomy     Full-text available via subscription   (Followers: 15, SJR: 2.071, h-index: 82)
Advances in Anesthesia     Full-text available via subscription   (Followers: 25, SJR: 0.169, h-index: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 3)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 6, SJR: 1.054, h-index: 35)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 10, SJR: 0.801, h-index: 26)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 22, SJR: 1.286, h-index: 49)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
Advances in Botanical Research     Full-text available via subscription   (Followers: 3, SJR: 0.619, h-index: 48)
Advances in Cancer Research     Full-text available via subscription   (Followers: 25, SJR: 2.215, h-index: 78)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 0.9, h-index: 30)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 2.139, h-index: 42)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 24, SJR: 0.183, h-index: 23)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 10, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 16, SJR: 0.223, h-index: 22)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 11)
Advances in Digestive Medicine     Open Access   (Followers: 4)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Ecological Research     Full-text available via subscription   (Followers: 42, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 25, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 7)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 40, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 3)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 47, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 15)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 21, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.497, h-index: 31)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 26)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 35, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 3, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 5)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 4)
Advances in Life Course Research     Hybrid Journal   (Followers: 8, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 2)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Marine Biology     Full-text available via subscription   (Followers: 16, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 22)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 10)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 4)
Advances in Oncobiology     Full-text available via subscription   (Followers: 3)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 24, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 13)
Advances in Pharmacology     Full-text available via subscription   (Followers: 15, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 7, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 4)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 19, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 60)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 2, SJR: 0.1, h-index: 2)
Advances in Space Research     Full-text available via subscription   (Followers: 345, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 8)
Advances in Surgery     Full-text available via subscription   (Followers: 7, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 30, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 16)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 43, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 5, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 310, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 5, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 8, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 408, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 30, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 38, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access  
Agriculture and Natural Resources     Open Access   (Followers: 1)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 53, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 5, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 9, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 6)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access  
Algal Research     Partially Free   (Followers: 8, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 4, SJR: 0.776, h-index: 35)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 7, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 48, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 5)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 3)
American Heart J.     Hybrid Journal   (Followers: 48, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 45, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 38, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 6, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 16, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 31, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 24, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 33, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 46, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 187, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 54, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 3)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 23, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 26, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 21, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 34, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 5)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 55, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 9)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 2, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 38, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 164, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 8, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 11)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 1)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 22, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access  
Animal Behaviour     Hybrid Journal   (Followers: 158, SJR: 1.907, h-index: 126)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 5, SJR: 1.151, h-index: 83)
Animal Reproduction Science     Hybrid Journal   (Followers: 5, SJR: 0.711, h-index: 78)
Annales d'Endocrinologie     Full-text available via subscription   (Followers: 1, SJR: 0.394, h-index: 30)
Annales d'Urologie     Full-text available via subscription  
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (SJR: 0.177, h-index: 13)
Annales de Chirurgie de la Main et du Membre Supérieur     Full-text available via subscription  
Annales de Chirurgie Plastique Esthétique     Full-text available via subscription   (Followers: 2, SJR: 0.354, h-index: 22)
Annales de Chirurgie Vasculaire     Full-text available via subscription   (Followers: 1)

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Journal Cover Actas Dermo-Sifiliograficas
  [4 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 0001-7310
   Published by Elsevier Homepage  [3043 journals]
  • Disfunción cardíaca en la epidermólisis ampollosa
    • Authors: M.T. Villarroel Salcedo
      First page: 498
      Abstract: Publication date: July–August 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 6
      Author(s): M.T. Villarroel Salcedo


      PubDate: 2017-07-04T07:22:11Z
      DOI: 10.1016/j.ad.2017.03.004
       
  • Micosis fungoide en pacientes pediátricos: un reto diagnóstico
    • Authors: R.I. Belloso
      First page: 499
      Abstract: Publication date: July–August 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 6
      Author(s): R.I. Belloso


      PubDate: 2017-07-04T07:22:11Z
      DOI: 10.1016/j.ad.2017.02.010
       
  • Consideraciones sobre los análisis de subgrupos en los ensayos
           clínicos
    • Authors: P. Coto-Segura
      First page: 501
      Abstract: Publication date: July–August 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 6
      Author(s): P. Coto-Segura


      PubDate: 2017-07-04T07:22:11Z
      DOI: 10.1016/j.ad.2017.03.003
       
  • Psoriasis y comorbilidad psiquiátrica: la próxima frontera
    • Authors: J.M. Carrascosa; F. Ballesca
      Pages: 502 - 505
      Abstract: Publication date: July–August 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 6
      Author(s): J.M. Carrascosa, F. Ballesca


      PubDate: 2017-07-04T07:22:11Z
      DOI: 10.1016/j.ad.2017.04.001
       
  • Psoriasis e hígado graso no alcohólico
    • Authors: J.M. Carrascosa; C. Bonanad; E. Dauden; R. Botella; A. Olveira-Martín
      Pages: 506 - 514
      Abstract: Publication date: July–August 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 6
      Author(s): J.M. Carrascosa, C. Bonanad, E. Dauden, R. Botella, A. Olveira-Martín
      El hígado graso no alcohólico es la principal causa de enfermedad hepática en nuestro medio. Los pacientes con psoriasis presentan mayor prevalencia y gravedad y peor pronóstico de esta hepatopatía. El vínculo patogénico entre ambas es el estado de inflamación crónica y la resistencia periférica a la insulina, habitual en las comorbilidades asociadas a la psoriasis. Por este motivo, en la evaluación de los pacientes con psoriasis, en particular si existen componentes del síndrome metabólico y se requiere tratamiento sistémico, se recomienda descartar esta posibilidad. La coexistencia de psoriasis e hígado graso no alcohólico, con probable sinergia entre ambos, condiciona las medidas generales que deben recomendarse en estos pacientes y también la estrategia terapéutica, por la potencial hepatotoxicidad de algunos de ellos. En este sentido, algunos de los fármacos convencionales habituales como acitretino, metotrexato o ciclosporina presentan potenciales efectos hepatotóxicos cuya repercusión en cada paciente debe evaluarse de forma individualizada. Los fármacos anti-TNF podrían tener efectos beneficiosos fundamentados en el buen control del proceso inflamatorio y de una mejoría de la resistencia periférica a la insulina. Sin embargo, se han descrito casos de hepatotoxicidad en algunos pacientes. No existe evidencia de efectos beneficiosos o perjudiciales de los fármacos anti p40 o anti IL-17. Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver condition in the West. The prevalence and severity of NAFLD is higher and the prognosis worse in patients with psoriasis. The pathogenic link between psoriasis and NAFLD is chronic inflammation and peripheral insulin resistance, a common finding in diseases associated with psoriasis. NAFLD should therefore be ruled out during the initial evaluation of patients with psoriasis, in particular if they show signs of metabolic syndrome and require systemic treatment. Concomitant psoriasis and NAFLD and the likelihood of synergy between them place limitations on general recommendations and treatment for these patients given the potential for liver toxicity. As hepatotoxic risk is associated with some of the conventional drugs used in this setting (e.g., acitretin, methotrexate, and ciclosporin), patients prescribed these treatments should be monitored as appropriate. Anti-tumor necrosis factor agents hold the promise of potential benefits based on their effects on the inflammatory process and improving peripheral insulin resistance. However, cases of liver toxicity have also been reported in relation to these biologics. No evidence has emerged to suggest that anti-p40 or anti-interleukin 17 agents provide benefits or have adverse effects.
      Graphical abstract image

      PubDate: 2017-07-04T07:22:11Z
      DOI: 10.1016/j.ad.2016.12.017
       
  • Angiogenesis in Dermatology – Insights of Molecular Mechanisms and
           Latest Developments
    • Authors: N.A. Richarz; A. Boada; J.M. Carrascosa
      Pages: 515 - 523
      Abstract: Publication date: July–August 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 6
      Author(s): N.A. Richarz, A. Boada, J.M. Carrascosa
      Angiogenesis is the growth of new blood vessels from pre-existing vessels. It is a biological process essential in physiological wound healing or pathological inflammation and tumor growth, which underlies a complex interplay of stimulating and inhibiting signals. Extracellular matrix, cells of innate and adaptive immunity and endothelial cells itself are a major source of angiogenic factors that activate or inhibit specific receptors and consequently influence intracellular signaling pathways. Most inflammatory and neoplastic diseases in dermatology are characterized by excessive angiogenesis, such as psoriasis, atopic dermatitis, as well as melanoma, non-melanoma skin cancer, but also benign vascular neoplasia. In this article we describe current knowledge of angiogenesis and its most relevant mechanisms in different dermatological disorders with particular emphasis on the angiogenic factors (vascular endothelial growth factor) and angiopoietins as a target of current and future directions of anti-angiogenic therapy.

      PubDate: 2017-07-04T07:22:11Z
      DOI: 10.1016/j.adengl.2016.12.022
       
  • Trasplante de folículos pilosos en úlceras crónicas: un
           nuevo concepto de injerto
    • Authors: M.L. Martínez Martínez; E. Escario Travesedo; F. Jiménez Acosta
      Pages: 524 - 531
      Abstract: Publication date: July–August 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 6
      Author(s): M.L. Martínez Martínez, E. Escario Travesedo, F. Jiménez Acosta
      Las úlceras venosas crónicas de los miembros inferiores representan un reto terapéutico importante en la práctica clínica diaria, resultando primordial la búsqueda de nuevas alternativas que mejoren la curación de estas heridas. Pese al tratamiento habitual con compresión, desbridamiento y uso de apósitos, muchas úlceras permanecen sin cicatrizar. En estas úlceras que no curan uno de los tratamientos más empleados es el trasplante de injertos cutáneos en sus diversas variantes: pinch grafts, punch grafts, injertos de piel de espesor parcial, injertos de piel de grosor total e injertos elaborados a partir de células cultivadas en laboratorio. En los últimos años numerosos estudios han destacado el importante papel del folículo piloso en el proceso de cicatrización de las heridas cutáneas. Trasladando a la práctica estos conocimientos se han utilizado folículos pilosos del cuero cabelludo en injertos tipo punch que son trasplantados al lecho de las úlceras crónicas para estimular su curación. Los resultados parecen ser mejores que el trasplante tradicional de injertos tipo punch sin pelo, lo cual proporciona nuevas líneas de tratamiento para las úlceras venosas crónicas recalcitrantes. Chronic venous leg ulcers are a major therapeutic challenge in clinical practice, and the search for new approaches to improve wound healing is essential. Many ulcers do not heal with traditional treatment using compression, debridement, and dressings. Skin-grafts variants, such as pinch grafts, punch grafts, split- or full-thickness skin grafts, and grafts derived from cells cultured in the laboratory, are among the most widely used options in ulcers that do not heal. In recent years, numerous studies have brought to our attention the important role of the hair follicle in the healing process of cutaneous wounds. Putting knowledge into practice, hair follicles from the scalp have been used in punch-type grafts transplanted to the base of chronic ulcers to stimulate healing. Results appear to be better than those with traditional hairless punch grafts, opening new lines of treatment for recalcitrant chronic venous ulcers.
      Graphical abstract image

      PubDate: 2017-07-04T07:22:11Z
      DOI: 10.1016/j.ad.2017.02.013
       
  • Miocardiopatía en pacientes con epidermólisis ampollosa
           hereditaria
    • Authors: A. Batalla; A. Vicente; J. Bartrons; F. Prada; C. Fortuny; M.A. González-Enseñat
      Pages: 544 - 549
      Abstract: Publication date: July–August 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 6
      Author(s): A. Batalla, A. Vicente, J. Bartrons, F. Prada, C. Fortuny, M.A. González-Enseñat
      Introducción y objetivos En las últimas décadas se ha descrito la asociación entre epidermólisis ampollosa (EA) y miocardiopatía dilatada (MD). Generalmente esta última enfermedad se detecta en fases avanzadas, implicando un peor pronóstico. Nuestro objetivo consistió en determinar la prevalencia de MD en los pacientes con EA vistos en el Hospital San Joan de Déu (Barcelona) desde mayo de 1986 a abril de 2015. Métodos Estudio descriptivo transversal mediante revisión de las historias clínicas con atención al tipo y subtipos mayores de EA y la existencia o no de MD. Resultados Se recogieron 57 pacientes con diagnóstico de EA. De ellos 19 presentaban EA simple, 10 EA juntural, 27 EA distrófica (14 EA distrófica dominante y 13 EA distrófica recesiva) y existió un caso de síndrome de Kindler. Solo 2 de los pacientes con EA distrófica recesiva presentaron MD. En 23 de los pacientes con EA existieron factores que podrían tener una relación causal con el potencial desarrollo de MD. Conclusión La MD puede ser una complicación en los pacientes con EA, mayoritariamente del subtipo de EA distrófica recesiva, por lo que deben hacerse controles periódicos para su temprano diagnóstico y tratamiento. Introduction and objective In recent decades, an association has been reported between epidermolysis bullosa (EB) and dilated cardiomyopathy (DC). DC is typically in an advanced phase when detected, leading to a poorer prognosis. Our objective was to determine the prevalence of DC in patients with EB seen in Hospital San Joan de Déu in Barcelona, Spain, between May 1986 and April 2015. Methods This was a descriptive, cross-sectional chart-review study in which we recorded the type and main subtypes of EB and the presence or absence of DC. Results Fifty-seven patients with EB were found, 19 with EB simplex, 10 with junctional EB, 27 with dystrophic EB (14 dominant dystrophic and 13 recessive dystrophic), and just 1 with Kindler syndrome. DC was detected in only 2 patients with recessive dystrophic EB. Twenty-three patients had presented factors that could have had a causal relationship with the potential onset of DC. Conclusion DC is a possible complication of EB, particularly in recessive dystrophic EB. Periodic follow-up should be performed to make an early diagnosis and start treatment.
      Graphical abstract image

      PubDate: 2017-07-04T07:22:11Z
      DOI: 10.1016/j.ad.2017.01.015
       
  • Comparison of ixekizumab with etanercept or placebo in moderate-to-severe
           psoriasis: Subgroup analysis of Latin American patients in the phase 3
           randomized UNCOVER-3 study
    • Authors: F. Valenzuela; C. de la Cruz Fernandez; R.L. Galimberti; S. Gürbüz; M. McKean-Matthews; L. Goncalves; R. Romiti
      Pages: 550 - 563
      Abstract: Publication date: July–August 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 6
      Author(s): F. Valenzuela, C. de la Cruz Fernandez, R.L. Galimberti, S. Gürbüz, M. McKean-Matthews, L. Goncalves, R. Romiti
      Background and objectives Ixekizumab demonstrated greater efficacy than placebo and etanercept in UNCOVER-3. Subgroup analysis of Latin American patients was performed. We report 12-week and 60-week data. Patients and methods Analysis included 102 Latin American patients randomized to receive placebo (n =14), etanercept 50mg twice weekly (n =30), or ixekizumab 160-mg starting dose followed by 80mg every 2 weeks (Q2W; n =29) or every 4 weeks (Q4W; n =29). At week 12, patients maintaining efficacy response and adequate overall safety were assigned, at the discretion of the investigator, to long-term extension with ixekizumab Q4W. Results At week 12, Psoriasis Area and Severity Index (PASI) 100 scores were 0%, 20.0% (p =0.075 vs placebo), 62.1% (p <0.001 vs placebo; p =0.001 vs etanercept), and 48.3% (p =0.002 vs placebo; p =0.023 vs etanercept) for placebo, etanercept, ixekizumab Q2W, and ixekizumab Q4W, respectively. Among patients who continued therapy up to week 60 (n =97), PASI 100 scores were 71.4%, 60.0%, 77.8%, and 57.7% for patients who received induction placebo, etanercept, ixekizumab Q2W, and ixekizumab Q4W, respectively (non-responder imputation). By week 60, ≥1 serious adverse event was experienced by 7.1% (n =1/14), 3.3% (n =1/30), 14.8% (n =4/27), and 0% (n =0/26) of patients who received induction placebo, etanercept, ixekizumab Q2W, and ixekizumab Q4W, respectively. There were no cases of active tuberculosis with ixekizumab treatment through 60 weeks. Conclusions In Latin American patients, both ixekizumab dosing regimens demonstrated greater efficacy than etanercept for treating psoriasis over 12 weeks. The safety profile of ixekizumab through 60 weeks was well tolerated and consistent with the overall profile.
      Graphical abstract image

      PubDate: 2017-07-04T07:22:11Z
      DOI: 10.1016/j.adengl.2017.02.026
       
  • Hiperpigmentación digital unilateral en adolescente
    • Authors: L. Campos Muñoz; A. Fueyo Casado; E. López Bran
      Abstract: Publication date: Available online 10 August 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): L. Campos Muñoz, A. Fueyo Casado, E. López Bran


      PubDate: 2017-08-16T07:55:41Z
      DOI: 10.1016/j.ad.2017.04.011
       
  • Pápulas múltiples con distribución unilateral y segmentaria
           en mujer de 65 años
    • Authors: S. Requena López; C. Maldonado Seral; B. Vivanco Allende
      Abstract: Publication date: Available online 10 August 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): S. Requena López, C. Maldonado Seral, B. Vivanco Allende


      PubDate: 2017-08-16T07:55:41Z
      DOI: 10.1016/j.ad.2017.06.012
       
  • Adaptación cultural al español del cuestionario Early Arthritis
           for Psoriatic patients
    • Authors: J. García-Gavín; L. Pérez-Pérez; I. Tinazzi; D. Vidal; D. McGonagle
      Abstract: Publication date: Available online 10 August 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): J. García-Gavín, L. Pérez-Pérez, I. Tinazzi, D. Vidal, D. McGonagle
      Introducción y objetivos El cuestionario Early Arthritis for Psoriatic patients (EARP) es una herramienta de screening para artritis psoriásica con buenas propiedades de medición en su versión original en italiano que no ha sido todavía adaptado culturalmente al español. Este artículo expone la adaptación para población española como paso previo a su validación. Material y método Aplicación de la metodología recomendada por la International Society for Pharmacoeconomics and Outcomes Research para adaptaciones culturales de medidas centradas en el paciente y que consta de las siguientes fases: preparación, traducción, reconciliación, retrotraducción y su revisión, armonización, test de comprensión y su revisión y corrección de pruebas. En la preparación se obtuvo el permiso de los autores del cuestionario original para su adaptación cultural y colaboraron durante el proceso como asesores. Resultados La traducción del cuestionario original al español la realizaron traductores nativos que realizaron pequeñas modificaciones aceptadas por los autores de la versión original. Se realizó la retrotraducción al italiano, obteniendo una versión equivalente al EARP original. La versión española de la retrotraducción se aplicó en el test de comprensión a 35 pacientes. Todos ellos contestaron a todos los ítems sin hacer aportaciones adicionales. Conclusión La adaptación cultural del cuestionario EARP para población española constituye la primera etapa para su posterior uso en práctica clínica habitual. La aplicación de una metodología estandarizada garantiza la equivalencia entre el EARP en español y el original. En una segunda etapa se realizará la validación en población española. Introduction and objectives The Early Arthritis for Psoriatic patients (EARP) questionnaire is a screening tool for psoriatic arthritis with good measuring properties in its original Italian version but has not been culturally adapted to Spanish. This article presents the adaptation for Spanish population, prior to validation step. Material and method Application of the methodology recommended by the International Society Pharmacoeconomic and Outcome Research for cultural adaptations of measures focused on the patient and comprising the steps of: preparation, translation, reconciliation, back translation and review, harmonization, cognitive debriefing and review, proofreading. In preparing, the permission of the authors of the original questionnaire for cultural adaptation was obtained and they worked as a consultant during the process. Results The translation of the original questionnaire into Spanish was made by native translators who made minor modifications accepted by the authors of the original version. The back-translation into Italian was performed, obtaining an equivalent to the original EARP version. The Spanish version of the back-translation was answered by 35 patients in a cognitive debriefing. They answered all items without making additional contributions. Conclusion The cultural adaptation of the questionnaire EARP for Spanish population is the first step for later use in routine clinical practice. The standardized methodology ...
      PubDate: 2017-08-16T07:55:41Z
      DOI: 10.1016/j.ad.2017.06.006
       
  • Aspergilosis cutánea secundaria pustulosa en paciente inmunosuprimido
    • Authors: P. Fonda-Pascual; P. Fernández-González; O.M. Moreno-Arrones; L. Miguel-Gómez
      Abstract: Publication date: Available online 10 August 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): P. Fonda-Pascual, P. Fernández-González, O.M. Moreno-Arrones, L. Miguel-Gómez


      PubDate: 2017-08-16T07:55:41Z
      DOI: 10.1016/j.ad.2017.07.004
       
  • Primera descripción ecográfica del angiosarcoma cutáneo idiopático de
           cabeza y cuello
    • Authors: P. Vilas Boas; A. Ruedas Martínez; O. Baniandrés Rodriguez; C. Ciudad Blanco
      Abstract: Publication date: Available online 10 August 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): P. Vilas Boas, A. Ruedas Martínez, O. Baniandrés Rodriguez, C. Ciudad Blanco


      PubDate: 2017-08-16T07:55:41Z
      DOI: 10.1016/j.ad.2017.02.026
       
  • Tratamiento con electrocirugía del rinofima moderado-grave
    • Authors: L.F. González; H. Herrera; A. Motta
      Abstract: Publication date: Available online 9 August 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): L.F. González, H. Herrera, A. Motta
      El rinofima se considera el estado final de la rosácea, siendo una condición desfigurante progresiva y poco común. Existen diferentes alternativas quirúrgicas como la dermoabrasión, la criocirugía, la escisión con escalpelo, la electrocirugía y el láser CO2. Estas 2 últimas técnicas son las más efectivas en el manejo del rinofima. Se describe una serie de casos de pacientes con rinofima moderado-grave que recibieron manejo con electrocirugía de alta frecuencia en el Servicio de Dermatología del Hospital Simón Bolívar y práctica privada entre 2012 y 2016. Todos los pacientes mostraron respuesta estética satisfactoria basada en el criterio médico y la percepción del paciente. Tres pacientes presentaron cicatrices hipertróficas manejadas con infiltraciones y bandas de silicona. Dos pacientes presentaron eritema persistente. Ningún caso requirió un segundo tiempo quirúrgico, ni infección grave. La electrocirugía es una de las técnicas vigentes más coste-efectivas y de fácil realización por el dermatólogo para el tratamiento del rinofima. Rhinophyma, a rare and progressive disfiguring condition, is thought to be the final stage of rosacea. Several surgical treatments are available, including dermabrasion, cryosurgery, scalpel excision, electrosurgery, and carbon dioxide laser. The last 2 techniques are the most effective for the management of rhinophyma. We describe a series of cases of moderate or severe rhinophyma treated with high-frequency electrosurgery in the dermatology department of Hospital Simón Bolivar and in private clinics in Bogota, Colombia, between 2012 and 2016. The cosmetic result, as assessed by both the clinicians and the patients, was satisfactory in all cases. Three patients presented hypertrophic scars that were treated with steroid injections and silicone gel sheeting. Two patients presented persistent erythema. However, there were no serious infections and none of the patients required further surgery. Electrosurgery is one of the simplest and most cost-effective techniques currently available for the treatment of rhinophyma by dermatologists.
      Graphical abstract image

      PubDate: 2017-08-16T07:55:41Z
      DOI: 10.1016/j.ad.2017.02.033
       
  • Selfie de la cirugía de Mohs en España
    • Abstract: Publication date: Available online 9 August 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M. de Troya-Martín


      PubDate: 2017-08-16T07:55:41Z
       
  • FR-Rituximab, una revolución en el tratamiento del pénfigo
    • Authors: D. Morgado-Carrasco; P. Giavedoni; X. Fustà-Novell; P. Iranzo
      Abstract: Publication date: Available online 9 August 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): D. Morgado-Carrasco, P. Giavedoni, X. Fustà-Novell, P. Iranzo


      PubDate: 2017-08-16T07:55:41Z
      DOI: 10.1016/j.ad.2017.06.010
       
  • Descripción de las intervenciones quirúrgicas recogidas en el registro
           español de cirugía de Mohs (REGESMOHS) (2013-2015)
    • Authors: E. de Eusebio Murillo; A. Martín Fuentes; V. Ruiz-Salas; J.R. Garcés; R. Miñano Medrano; J.L. López-Estebaranz; T. Alonso-Alonso; M.Á. Rodríguez-Prieto; Y. Delgado Jiménez; V. Morales; P. Redondo Bellón; E. Manubens-Mercadé; O. Sanmartín-Jiménez; C. Guillén Barona; R. Cabeza; N. Cano; A. Toll-Abelló; R. Navarro Tejedor; J.L. Artola Igarza; I. Allende Markixana; A. Alfaro Rubio; C. Ciudad Blanco; H. Vázquez-Veiga; L. Barchino Ortiz; M.A. Descalzo; I. García-Doval
      Abstract: Publication date: Available online 9 August 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): E. de Eusebio Murillo, A. Martín Fuentes, V. Ruiz-Salas, J.R. Garcés, R. Miñano Medrano, J.L. López-Estebaranz, T. Alonso-Alonso, M.Á. Rodríguez-Prieto, Y. Delgado Jiménez, V. Morales, P. Redondo Bellón, E. Manubens-Mercadé, O. Sanmartín-Jiménez, C. Guillén Barona, R. Cabeza, N. Cano, A. Toll-Abelló, R. Navarro Tejedor, J.L. Artola Igarza, I. Allende Markixana, A. Alfaro Rubio, C. Ciudad Blanco, H. Vázquez-Veiga, L. Barchino Ortiz, M.A. Descalzo, I. García-Doval
      Introducción El Registro Español de Cirugía de Mohs recoge los datos de aplicación y resultados de esta técnica en España. Se describen los datos de las intervenciones realizadas desde el inicio del Registro en julio de 2013 a enero de 2016. Se analizan los datos de las cirugías tanto perioperatorios como intraoperatorios. Material y métodos Estudio de cohortes prospectivo en el que participan 18 centros. Se recogen los datos de las intervenciones quirúrgicas como tipo de anestesia, técnica quirúrgica, ingreso hospitalario, número de estadios, manejo de factores de riesgo preoperatorios, tratamientos complementarios, tratamientos previos, tipo de tumor, tiempo empleado en la cirugía y complicaciones. Resultados Se analizan 1.796 intervenciones quirúrgicas. El tumor intervenido con más frecuencia es el carcinoma basocelular (85,96%), seguido del carcinoma epidermoide (6,18%), lentigo maligno (2,81%) y dermatofibrosarcoma protuberans (1,97%). El 66,9% de los tumores eran primarios, el 19,2% recurrentes y el 13,9% persistentes. El tratamiento previo más frecuente fue quirúrgico. La cirugía de Mohs se realizó con más frecuencia bajo anestesia local (86,7%) y de forma ambulatoria (71,8%). En el 89,5% de los casos se utilizó la técnica de Mohs en congelación. El número de etapas requerido para alcanzar márgenes libres de tumor fue una en 56,45% de los pacientes, 2 en 32,1%, 3 en 7,1%, 4 en 2,7% y 5 o más en 1,8%. El propio dermatólogo reconstruyó el defecto en el 98% de los pacientes y la técnica reconstructiva más utilizada fue el colgajo (47,2%). Solo el 1,62% de los pacientes presentó alguna complicación intraoperatoria y la mediana de la duración de la cirugía fue 75 (p25:60-p75:100). Conclusión Las características de los pacientes y tumores tratados son similares a las descritas en estudios de las mismas características en otras áreas geográficas. Existe un porcentaje mayor de lentigo maligno y dermatofibrosarcoma protuberans. La reconstrucción la realiza el dermatólogo con más frecuencia que en otras series. El tiempo de utilización de quirófano no es mucho mayor que para otras técnicas y la tasa de complicaciones intraoperatorias es muy reducida. Introduction The Spanish Mohs Surgery Registry is used to collect data on the use and outcomes of Mohs micrographic surgery (MMS) in Spain. The aim of this study was to describe perioperative and intraoperative data recorded for MMS procedures performed between July 2013 (when the registry started) and January 2016. Material and methods Prospective cohort study of data from 18 hospitals. The data collected included type of anesthesia, surgical technique, hospital admission, number of Mohs stages, management of preoperative risk factors, additional treatments, previous treatments, type of tumor, operating time, and complications. Results Data were available for 1796 operations. The most common tumor treated by MMS was basal cell carcinoma (85.96%), followed by squamous cell carcinoma (6.18%), lentigo maligna (2....
      PubDate: 2017-08-16T07:55:41Z
      DOI: 10.1016/j.ad.2017.04.018
       
  • La dermatoscopia sugiere el estado evolutivo de las queratosis
           actínicas
    • Authors: P. Zaballos Diego
      Abstract: Publication date: Available online 9 August 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): P. Zaballos Diego


      PubDate: 2017-08-16T07:55:41Z
      DOI: 10.1016/j.ad.2017.07.005
       
  • El estado de la investigación clínica en dermatología en
           España
    • Authors: Seijo
      Abstract: Publication date: Available online 9 August 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): P. Dávila Seijo


      PubDate: 2017-08-16T07:55:41Z
       
  • La psoriasis protege frente a una dosis eritemática mínima
           patológica
    • Authors: M.V.
      Abstract: Publication date: Available online 8 August 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M.V. de Gálvez


      PubDate: 2017-08-16T07:55:41Z
       
  • Valor de la ecografía ganglionar previa a la biopsia del ganglio
           centinela en 384 pacientes con melanoma: análisis de coste-efectividad
    • Authors: D. Olmedo; M. Brotons-Seguí; C. del Toro; M. González; C. Requena; V. Traves; A. Pla; I. Bolumar; D. Moreno-Ramírez; E. Nagore
      Abstract: Publication date: Available online 8 August 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): D. Olmedo, M. Brotons-Seguí, C. del Toro, M. González, C. Requena, V. Traves, A. Pla, I. Bolumar, D. Moreno-Ramírez, E. Nagore
      Introducción y objetivos La ecografía ganglionar locorregional como parte de la estadificación previa a la biopsia del ganglio centinela (BSGC) en pacientes con melanoma no se incluye habitualmente en las guías de manejo. El objetivo de este estudio es evaluarla desde la perspectiva clínica y económica. Pacientes y métodos Estudio retrospectivo de 384 pacientes con melanoma primario de estadios clínicos I-II, en el periodo 2004-2015, a los que se les realizó una ecografía ganglionar locorregional (±biopsia ecodirigida) previa a la BSGC. Se evaluó la fiabilidad de la técnica y se realizó un análisis de su coste efectividad. Resultados En 23 pacientes (6%) se pudo evitar la realización de la BSGC mediante la técnica. La ecografía mostró una sensibilidad del 46% y una especificidad del 76% para la detección de ganglios metastásicos clínicamente no palpables. Los falsos negativos fueron significativamente más frecuentes en pacientes mayores de 60 años y con tumores <2mm. El coste unitario del proceso de estadificación mediante BSGC con ecografía-biopsia ecodirigida generó un sobrecoste de 16,30 €. El análisis coste-efectividad identificó como estrategia dominante desde ese punto de vista el protocolo de estadificación con ecografía y BSGC, con una ratio coste-efectividad inferior a la de la alternativa consistente en BSGC (8.095,24 vs. 28.605,00 €) Conclusiones La ecografía con biopsia ecodirigida como método diagnóstico de estadificación previo a la BSGC es una herramienta útil y coste-efectiva, que no sustituye a la BSGC, pero que permite en un porcentaje no desdeñable de casos evitar su realización. Background and objectives Locoregional lymph node ultrasound is not typically included in guidelines as part of the staging process prior to sentinel lymph node biopsy (SLNB). The objective of the present study was to make a clinical and economic analysis of lymph node ultrasound prior to SLNB. Materials and methods We performed a retrospective study of 384 patients with clinical stage I-II primary melanoma who underwent locorregional lymph node ultrasound (with or without ultrasound-guided biopsy) prior to SLNB between 2004 and 2015. We evaluated the reliability and cost-effectiveness of the strategy. Results Use of locorregional lymph node ultrasound avoided SLNB in 23 patients (6%). Ultrasound had a sensitivity of 46% and specificity of 76% for the detection of metastatic lymph nodes that were not clinically palpable. False negatives were significantly more common in patients aged over 60 years and in tumors with a thickness of less than 2mm. The staging process using SLNB and ultrasound with ultrasound-guided biopsy produced an increase of €16.30 in the unit price. Our cost-effectiveness analysis identified the staging protocol with ultrasound and SLNB as the dominant strategy, with a lower cost-effectiveness ratio than the alternative, consisting of SLNB alone (8,095.24 vs. €28,605.00). Conclusions Ultrasound with ultrasound-guided biopsy for the diagnostic staging of me...
      PubDate: 2017-08-16T07:55:41Z
      DOI: 10.1016/j.ad.2017.06.002
       
  • Paraneoplastic Pemphigus. A Life-Threatening Autoimmune Blistering Disease
    • Authors: Bonifaz
      Abstract: Publication date: Available online 8 August 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): A. Tirado-Sánchez, A. Bonifaz
      Paraneoplastic pemphigus (PNP), a subset of pemphigus, is a unique autoimmune blistering condition that can affect multiple organs other than the skin. It is a life-threatening disease associated with an underlying malignancy, most commonly of lymphoproliferative origin. The clinical picture may resemble pemphigus, pemphigoid, erythema multiforme, graft-versus-host disease, or lichen planus. The earliest and most consistent finding is a painful, severe, chronic and often recalcitrant stomatitis. Treatment of PNP is difficult. Immunosuppressive agents are required to decrease blistering, and treating the underlying tumor may control autoantibody production. In this review, we included essential diagnostic aspects of PNP and the most useful treatment options in the dermatologist practice.
      Graphical abstract image

      PubDate: 2017-08-16T07:55:41Z
       
  • Infiltración cutánea por macroglobulinemia de Waldenström
    • Authors: S. Oscoz-Jaime; A.D. Agulló-Pérez; C. Llanos-Chavarri; J.I. Yanguas-Bayona
      Abstract: Publication date: Available online 4 August 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): S. Oscoz-Jaime, A.D. Agulló-Pérez, C. Llanos-Chavarri, J.I. Yanguas-Bayona


      PubDate: 2017-08-06T07:47:41Z
      DOI: 10.1016/j.ad.2017.04.021
       
  • Dermatosis ampollosa IgA lineal con presentación clínica de necrólisis
           epidérmica tóxica
    • Authors: J. Ruiz-Rivero; I. Hernández-Aragüés; A. Pulido-Pérez; R. Suárez-Fernández
      Abstract: Publication date: Available online 24 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): J. Ruiz-Rivero, I. Hernández-Aragüés, A. Pulido-Pérez, R. Suárez-Fernández


      PubDate: 2017-07-28T07:40:12Z
      DOI: 10.1016/j.ad.2017.02.022
       
  • Los nuevos sistemas de estadificación del AJCC incorporan novedades en el
           cáncer cutáneo
    • Abstract: Publication date: Available online 18 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): J. Cañueto, C. Román-Curto
      Cuarenta años después de la publicación de la primera edición de la estadificación del American Joint Committee on Cancer, la octava edición se publica con cambios relevantes en el cáncer de piel. En el cáncer cutáneo no melanoma el American Joint Committee on Cancer mantiene un enfoque específico para el carcinoma de células de Merkel y tiene en cuenta algunos trabajos publicados recientemente sobre el pronóstico del carcinoma epidermoide cutáneo en la definición de una categoría T completamente nueva para este tumor. Por otra parte, la estadificación se contempla para el carcinoma epidermoide cutáneo de cabeza y cuello (excluyendo el párpado) y en otras localizaciones; únicamente ofrece soluciones para la estratificación de tumores de vulva, pene y región perineal. En relación con el melanoma, el valor del índice mitótico desaparece y el pronóstico del tumor primario se define basándose en el espesor de Breslow y la ulceración. Además, el espesor pasa a registrarse con una precisión de 0,1mm y aparece el concepto de T0 para los melanomas metastásicos en los que el primario ha regresado completamente. Existen diferencias en la categoría N de todos los sistemas de estadificación de cáncer cutáneo en esta nueva edición, y en relación con la categoría M, en el melanoma aparece la categoría M1d para hacer referencia a la afectación metastásica del SNC, que hasta el momento se incluía dentro de la categoría M1c. Será necesario validar este nuevo sistema con series de pacientes para valorar si efectivamente cumple con el objetivo de estratificar por riesgo los tumores de una manera adecuada. The eighth edition of the staging manual of the American Joint Committee on Cancer incorporates important changes in the classification of skin cancers. Coming 40 years after the first edition, the latest manual preserves its specific system for Merkel cell carcinoma and takes into account recent publications on the prognosis of squamous cell carcinoma by defining a completely new T category for this neoplasm. Staging for squamous cell carcinoma considers head and neck tumors (excluding the eyelid) and does not offer solutions for other sites except the vulva, penis, and perianal region. Regarding melanoma, use of the mitotic index has been eliminated and the prognosis of the primary tumor is based on Breslow thickness and ulceration. In addition, thickness is now recorded to an accuracy of 0.1mm, and the T0 concept has been introduced to define those metastatic melanomas in which the primary tumor has regressed completely. In this new edition, changes have also been made to the N category of all the skin cancer staging systems, and M1d has been added to the M category for melanoma to refer to metastatic involvement of the central nervous system, which, up to now, had been included in the M1c category. This new system will need to be validated with patient series to determine if it adequately satisfies the objective of tumor risk stratification.

      PubDate: 2017-07-22T07:35:42Z
       
  • Síndrome de Schnitzler con respuesta a anakinra en monoterapia: 7
           años de seguimiento
    • Authors: Y. Hidalgo-García; E. García-Fernández; L. Palacio-Aller; P. Gonzalvo
      Abstract: Publication date: Available online 17 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): Y. Hidalgo-García, E. García-Fernández, L. Palacio-Aller, P. Gonzalvo


      PubDate: 2017-07-22T07:35:42Z
      DOI: 10.1016/j.ad.2017.03.015
       
  • Carcinoma mucinoso primario cutáneo: presentación de un caso
    • Authors: C. Areán-Cuns; A. Córdoba-Iturriagagoitia; B. Aguiar-Losada; I. Yanguas-Bayona
      Abstract: Publication date: Available online 17 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): C. Areán-Cuns, A. Córdoba-Iturriagagoitia, B. Aguiar-Losada, I. Yanguas-Bayona


      PubDate: 2017-07-22T07:35:42Z
      DOI: 10.1016/j.ad.2017.03.013
       
  • Granuloma anular posiblemente secundario a la ingesta de topiramato
    • Authors: S. Heras-González; T. Piqueres-Zubiaurre; A. Martínez de Salinas-Quintana; R. González-Pérez
      Abstract: Publication date: Available online 13 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): S. Heras-González, T. Piqueres-Zubiaurre, A. Martínez de Salinas-Quintana, R. González-Pérez


      PubDate: 2017-07-22T07:35:42Z
      DOI: 10.1016/j.ad.2017.03.016
       
  • Tratamiento de la hiperhidrosis palmar con toxina botulínica mediante
           bloqueo de los nervios periféricos al nivel de la muñeca
    • Authors: A. de Quintana-Sancho; M.T. Conde Calvo
      Abstract: Publication date: Available online 12 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): A. de Quintana-Sancho, M.T. Conde Calvo


      PubDate: 2017-07-22T07:35:42Z
      DOI: 10.1016/j.ad.2017.05.013
       
  • Concordancia mutacional de BRAF entre melanoma primario cutáneo y sus
           correspondientes metástasis. Revisión de la evidencia actual
    • Authors: E. Godoy-Gijón; M. Yuste-Chaves; Á. Santos-Briz
      Abstract: Publication date: Available online 12 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): E. Godoy-Gijón, M. Yuste-Chaves, Á. Santos-Briz
      La mutación en el oncogén BRAF en melanoma y la aparición de terapias dirigidas frente a ella han supuesto un antes y un después en el tratamiento de esta enfermedad. El estudio del estado mutacional en las metástasis y su concordancia con el tumor primario tiene además una gran implicación terapéutica en estos pacientes, pues permite seleccionar candidatos a estos tratamientos. El objetivo de esta revisión es conocer las evidencias disponibles sobre el grado de concordancia en los distintos tipos de metástasis en el melanoma cutáneo, así como las ventajas y desventajas de los distintos métodos de detección de la mutación en BRAF. Identification of the BRAF oncogene mutation and the emergence of BRAF-targeted therapy marked a turning point in the treatment of melanoma. The study of mutation status concordance between primary tumors and metastases in this cancer has major treatment implications as it facilitates the selection of candidates for targeted therapy. The aim of this study was to review the evidence on the level of mutation status concordance between primary tumors and different types of metastases in cutaneous melanoma and to provide an overview of the advantages and disadvantages of the various methods used to detect the BRAF mutation.
      Graphical abstract image

      PubDate: 2017-07-22T07:35:42Z
      DOI: 10.1016/j.ad.2016.12.025
       
  • Acantomas epidermolíticos múltiples del escroto: lo que el
           prurito genital puede esconder
    • Authors: P. García-Martínez; L. Curto-Barredo; R. Rovira-López; R.M. Pujol
      Abstract: Publication date: Available online 11 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): P. García-Martínez, L. Curto-Barredo, R. Rovira-López, R.M. Pujol


      PubDate: 2017-07-12T07:28:30Z
      DOI: 10.1016/j.ad.2017.03.017
       
  • Malformación capilar adquirida (síndrome de Fegeler): 3 casos
    • Authors: J.F. Millán-Cayetano; J. del Boz; P. García-Montero; M. de Troya-Martín
      Abstract: Publication date: Available online 11 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): J.F. Millán-Cayetano, J. del Boz, P. García-Montero, M. de Troya-Martín


      PubDate: 2017-07-12T07:28:30Z
      DOI: 10.1016/j.ad.2017.02.028
       
  • Dermoscopy of Pigmented Actinic Keratosis of the Face: A Study of 232
           Cases
    • Authors: A. Kelati; H. Baybay; E. Moscarella; G. Argenziano; S. Gallouj; F.Z. Mernissi
      Abstract: Publication date: Available online 11 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): A. Kelati, H. Baybay, E. Moscarella, G. Argenziano, S. Gallouj, F.Z. Mernissi
      The diagnosis of pigmented actinic keratosis (PAK) is often challenging because of overlapping features with lentigo maligna. Objective To investigate dermoscopic patterns of PAK according to their different evolutionary stages, and to correlate the pattern with clinical characteristics of the patients. Methods Descriptive and analytical study of 232 PAK. Dermoscopic patterns were divided into two categories: the follicule surroundings’ abnormalities (FSA) and follicular keratosis’ abnormalities (FKA). Results FSA and FKA dermoscopic patterns were related to male gender, except for star-like appearance, double white clods and dermoscopic horn (p ≤0.04). Rhomboidal, annular granular pattern, gray halo, white circle and double clods were dermoscopic pattern significantly related to xeroderma pigmentosum's type of skin. Based on the evolutionary stages of PAK, the jelly sign was significantly related to thin patches of PAK. Central crusts and scales were related to thick plaques and the star-like appearance to hypertrophic PAK. The presence of 2 or more dermoscopic signs in both FSA and FKA was noticed in 99.1% of lesions. Conclusions The dermoscopic diagnosis of PAK vary according to the evolutionary stages of the disease, this will increase the diagnosis accuracy, with therapeutic implications.
      Graphical abstract image

      PubDate: 2017-07-12T07:28:30Z
      DOI: 10.1016/j.ad.2017.05.002
       
  • Liquen aureus: ¿un caso congénito'
    • Authors: O. Corral Magaña; J. Escalas Taberner; A. Bauzá Alonso; A. Martin-Santiago
      Abstract: Publication date: Available online 11 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): O. Corral Magaña, J. Escalas Taberner, A. Bauzá Alonso, A. Martin-Santiago


      PubDate: 2017-07-12T07:28:30Z
      DOI: 10.1016/j.ad.2017.04.023
       
  • Vacuna triple vírica como tratamiento de verruga subungueal
           recalcitrante
    • Authors: C. Morales-Raya; L. Maroñas-Jiménez; R. Aragón-Miguel; C. Postigo-Llorente
      Abstract: Publication date: Available online 11 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): C. Morales-Raya, L. Maroñas-Jiménez, R. Aragón-Miguel, C. Postigo-Llorente


      PubDate: 2017-07-12T07:28:30Z
      DOI: 10.1016/j.ad.2017.02.030
       
  • Pápulas umbilicadas en los codos en una paciente con una vasculitis
           sistémica
    • Authors: C. Lloret-Ruiz; N. Barrado-Solís; E. Quecedo-Estébanez
      Abstract: Publication date: Available online 11 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): C. Lloret-Ruiz, N. Barrado-Solís, E. Quecedo-Estébanez


      PubDate: 2017-07-12T07:28:30Z
      DOI: 10.1016/j.ad.2017.02.024
       
  • Lupus eritematoso con afectación genital: una localización
           inusual
    • Authors: E. del Alcázar-Viladomiu; A. López-Pestaña; A. Tuneu-Valls
      Abstract: Publication date: Available online 11 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): E. del Alcázar-Viladomiu, A. López-Pestaña, A. Tuneu-Valls


      PubDate: 2017-07-12T07:28:30Z
      DOI: 10.1016/j.ad.2017.05.010
       
  • Reacción local intensa en zonas de inyección de mesoterapia
           lipolítica
    • Authors: S. Córdoba; E. Rojas; A. Garrido-Ríos; J. Borbujo
      Abstract: Publication date: Available online 11 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): S. Córdoba, E. Rojas, A. Garrido-Ríos, J. Borbujo


      PubDate: 2017-07-12T07:28:30Z
      DOI: 10.1016/j.ad.2017.02.027
       
  • El dermatólogo y el cáncer de piel. Consideraciones sobre el
           posicionamiento de la Sociedad Española de Oncología Médica
    • Authors: D. Moreno-Ramírez; E. Nagore; R. Botella-Estrada; G. Carretero; S. Puig; P. Redondo; M.A. Rodrígurez-Prieto; E. Samaniego; O. Sanmartín; J. Malvehy
      Abstract: Publication date: Available online 10 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): D. Moreno-Ramírez, E. Nagore, R. Botella-Estrada, G. Carretero, S. Puig, P. Redondo, M.A. Rodrígurez-Prieto, E. Samaniego, O. Sanmartín, J. Malvehy


      PubDate: 2017-07-12T07:28:30Z
      DOI: 10.1016/j.ad.2017.06.003
       
  • Utilidad de la ecografía en el diagnóstico y seguimiento del
           pioderma gangrenoso
    • Authors: Aliste
      Abstract: Publication date: Available online 10 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M. Pousa-Martínez, D. Sánchez-Aguilar, C. Aliste, H. Vázquez-Veiga


      PubDate: 2017-07-12T07:28:30Z
       
  • Reconstrucción de defecto en cuero cabelludo mediante doble colgajo
           en hacha
    • Authors: A. Varela-Veiga; O. Suárez-Magdalena; Ó. Suárez-Amor; B. Monteagudo
      Abstract: Publication date: Available online 6 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): A. Varela-Veiga, O. Suárez-Magdalena, Ó. Suárez-Amor, B. Monteagudo


      PubDate: 2017-07-12T07:28:30Z
      DOI: 10.1016/j.ad.2017.04.019
       
  • ¿Es útil la determinación de la dosis eritematógena mínima previa a
           la fototerapia ultravioleta B de banda estrecha'
    • Authors: M.T. Rodríguez-Granados; A. Estany-Gestal; M. Pousa-Martínez; J. Labandeira; R. Gato Otero; V. Fernández-Redondo
      Abstract: Publication date: Available online 4 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M.T. Rodríguez-Granados, A. Estany-Gestal, M. Pousa-Martínez, J. Labandeira, R. Gato Otero, V. Fernández-Redondo
      Introducción y objetivos La dosis de inicio en la fototerapia UVB de banda estrecha (UVBBE) viene determinada por el fototipo o por la determinación de la dosis eritematógena mínima (DEM). El cálculo de la DEM identifica pacientes con fotosensibilidad no sospechada. El objetivo de nuestro estudio es conocer la influencia que puedan tener en una DEM disminuida los fármacos fotosensibilizantes concomitantes, el diagnóstico, la asociación con acitretina en pacientes con psoriasis y evidenciar si la DEM alterada provoca más reacciones adversas y más graves. Material y métodos Se trata de un estudio observacional de una cohorte retrospectiva desde el período comprendido entre el 1 de febrero de 2009 al 31 de marzo de 2015. La determinación de la DEM se categorizó en DEM normal o patológica. Resultados Trescientos dos pacientes con distintas dermatosis inician UVBBE en función de la DEM. No se han encontrado diferencias entre el grupo con DEM patológica respecto al normal, ni en el número de fármacos consumidos (p=0,071), ni en el potencial fotosensibilizante (p=0,806). El análisis multivariante ajustado por edad, sexo y fototipo reveló que la psoriasis es un factor protector de DEM patológica (OR=0,31 [IC 95%: 0,16-0,58]). No se encontró riesgo significativo de eritema ni prurito en los pacientes con DEM alterada OR=1,68 (IC 95%: 0,91-3,29) y OR=2,04 (IC 95%: 0,99-4,22), respectivamente. Conclusiones La psoriasis protege de tener una DEM patológica. Si bien el eritema y el prurito fueron más frecuentes en los pacientes con DEM patológica, las diferencias no fueron estadísticamente significativas. Introduction and objectives The starting dose for narrowband UV-B phototherapy is determined by a patient's skin phototype or minimal erythema dose (MED). Calculation of MED identifies patients with unsuspected photosensitivity. The aim of this study was to investigate the influence of factors such as concomitant use of photosensitizing agents, diagnosis, and combination with acitretin in patients with psoriasis on the frequency and severity of adverse effects in patients with a low MED to narrowband UV-B phototherapy. Material and methods We undertook a retrospective observational cohort study between February 1, 2009 and March 31, 2015. MED values were classified as normal or low. Results In total, 302 patients with different skin conditions started narrowband UV-B phototherapy at a dose determined by their MED. No differences were found between patients with a low MED and those with a normal MED for number of drugs taken (P =.071) or use of photosensitizing agents (P =0.806). Following adjustment for age, sex, and phototype, the multivariate analysis showed that psoriasis exerted a protective effect against a low MED (OR=0.31 [95% CI, 0.16-0.58]). No significant risk of erythema or pruritus was detected in patients with a low MED (OR=1.68; 95% CI, 0.91-3.29 and OR=2.04; 95% CI, 0.99-4.22, respectively). ...
      PubDate: 2017-07-12T07:28:30Z
      DOI: 10.1016/j.ad.2017.05.009
       
  • Virus Zika: manifestaciones cutáneas en 3 pacientes
    • Authors: A. Cosano-Quero; V. Velasco-Tirado; M.P. Sánchez Seco; L. Manzanedo-Bueno; M. Belhassen-García
      Abstract: Publication date: Available online 3 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): A. Cosano-Quero, V. Velasco-Tirado, M.P. Sánchez Seco, L. Manzanedo-Bueno, M. Belhassen-García
      La infección por el virus Zika debe sospecharse en viajeros o inmigrantes con clínica de viriasis (exantema, fiebre, artralgias, artritis, conjuntivitis, cefalea, etc.) y una historia epidemiológica compatible. Aunque las manifestaciones cutáneas se encuentran entre las más frecuentes no son específicas y su iconografía es escasa. Presentamos 3 casos, 2 viajeros y un inmigrante que comienzan con un exantema por virus Zika. Alcanzar el diagnóstico de forma rápida optimiza el manejo de estos pacientes, mejora el control de los casos graves y permite minimizar una posible transmisión autóctona dado el riesgo que supone la presencia del Aedes albopictus como potencial vector transmisor de esta enfermedad en el litoral mediterráneo español. Zika virus infection should be suspected in travelers or immigrants with the signs or symptoms of a viral infection (rash, fever, joint pains, conjunctivitis, headache, etc.) and a compatible epidemiological history. Although cutaneous manifestations are among the most common clinical signs of Zika, they are not specific and very few images are available. We present 3 patients (2 travelers and 1 immigrant) in whom a rash was the presenting manifestation of Zika virus infection. Prompt diagnosis optimizes outcomes in these patients, improves the management of severe disease, and minimizes the risk of local transmission by Aedes albopictus, now a potential local vector for the virus due to its presence in areas along Spain's Mediterranean coast.
      Graphical abstract image

      PubDate: 2017-07-04T07:22:11Z
      DOI: 10.1016/j.ad.2017.02.021
       
  • Ecografía Doppler color en malformaciones glomuvenosas con correlación
           clínica e histológica
    • Authors: X. Wortsman; F. Millard; L. Aranibar
      Abstract: Publication date: Available online 3 July 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): X. Wortsman, F. Millard, L. Aranibar
      Las malformaciones glomuvenosas son hamartomas originados por la presencia de células glómicas en el músculo liso de las estructuras vasculares. Presentamos una serie de 13 casos de malformaciones glomuvenosas evaluadas clínicamente, estudiadas con ecotomografía Doppler color y confirmadas histológicamente. En las ecografías se observaron en todos los casos formaciones dérmicas e hipodérmicas superficiales, moderadamente delimitadas, de ecoestructura mixta, pseudonodulares, hipoecogénicas y heterogéneas con áreas tubulares y lacunares anecogénicas pseudoquísticas. El 85% de los casos demostró presencia de vasos arteriales y venosos, con predominio de los de baja velocidad (≤ 15cm/s) sin shunts arteriovenosos. No se visualizó compromiso de estructuras profundas ni flebolitos. Los hallazgos clínicos y ecográficos podrían ayudar a precisar mejor el diagnóstico, la planificación quirúrgica o el seguimiento no invasivo en estas entidades. Glomuvenous malformations are hamartomatous lesions characterized by the presence of glomus cells in the vascular smooth muscle. We present the clinical and color Doppler ultrasound features of a series of 13 cases of histologically confirmed glomuvenous malformations. In all cases, the ultrasound study revealed moderately delimited superficial dermal and hypodermal pseudonodular structures of mixed echogenicity, with hypoechoic and heterogeneous areas and anechoic, pseudocystic tubular and lacunar zones. Arterial and venous vessels, mainly with a low flow (≤ 15cm/s) were observed in 85% of patients, but no arteriovenous shunts were present. Deeper structures were not affected and no phleboliths were detected. The clinical and ultrasound findings could facilitate diagnosis, surgical planning, and noninvasive follow-up in these tumors.
      Graphical abstract image

      PubDate: 2017-07-04T07:22:11Z
      DOI: 10.1016/j.ad.2017.04.013
       
  • Valor del trasplante capilar realizado por el dermatólogo
    • Abstract: Publication date: July–August 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 6
      Author(s): S. Vañó Galván


      PubDate: 2017-07-04T07:22:11Z
       
  • El eosinófilo como alerta
    • Abstract: Publication date: July–August 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 6
      Author(s): E. Rodríguez Díaz


      PubDate: 2017-07-04T07:22:11Z
       
  • Terapia fotodinámica antimicrobiana: un mundo por explorar
    • Abstract: Publication date: July–August 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 6
      Author(s): J. Romaní


      PubDate: 2017-07-04T07:22:11Z
       
  • Actualización del método Follicular Unit Extraction (FUE) del
           trasplante de pelo
    • Abstract: Publication date: July–August 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 6
      Author(s): F. Jiménez-Acosta, I. Ponce-Rodríguez
      La follicular unit extraction (FUE) es una técnica de trasplante capilar que utiliza punches de pequeño diámetro (0,8-1mm) para extraer las unidades foliculares. Aunque en sus primeros años tuvo escasa aceptación debido a la dificultad en extraer unidades foliculares intactas con un punch tan pequeño, la FUE se ha popularizado y es ya una alternativa a la técnica clásica de la tira (FUT). Entre los motivos, la cada vez mayor demanda por parte de los pacientes y la mayor habilidad de los cirujanos en las extracciones al contar con mejor instrumental y más experiencia. Entre las ventajas de la FUE destaca la reducción de molestias postoperatorias en la zona donante y el aspecto muy poco visible de las cicatrices puntiformes residuales. Sin embargo, la FUE requiere una mayor laboriosidad, aumentando el tiempo operatorio, y una larga curva de aprendizaje por parte del cirujano. Follicular unit extraction (FUE) is a hair transplantation technique that uses small punches (0.8-1 mm in diameter) to extract the follicular units (FUs). Though initially the technique was not widely accepted because of the difficulty of extracting intact follicular units with such small punches, it has since gained in popularity due mainly to rising patient demand, the availability of better instrumentation and greater surgical skill acquired from experience. It is now a recognised alternative to follicular unit transplantation (FUT), a technique based on harvesting the FUs from a strip of tissue. Among the advantages of FUE are less post-procedural discomfort in the donor zone and the barely visible scarring from the punches. However, FUE is a more laborious, time-consuming procedure that involves a long learning curve for the surgeon.

      PubDate: 2017-07-04T07:22:11Z
       
  • Causas y curas de las dermatosis en la obra de Hildegarda de Bingen
    • Abstract: Publication date: July–August 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 6
      Author(s): J. Romaní, M. Romaní


      PubDate: 2017-07-04T07:22:11Z
       
 
 
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