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Publisher: Elsevier   (Total: 3118 journals)

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Showing 1 - 200 of 3118 Journals sorted alphabetically
A Practical Logic of Cognitive Systems     Full-text available via subscription   (Followers: 7)
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 25, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 22, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 89, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 25, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 30, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 4)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 5, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 374, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 3)
Acta Biomaterialia     Hybrid Journal   (Followers: 27, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 1)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (Followers: 1, SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 236, SJR: 3.683, h-index: 202)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.615, h-index: 21)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 10, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription   (Followers: 1)
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 3, SJR: 0.311, h-index: 16)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 2)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 25, SJR: 1.365, h-index: 73)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 4)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 4, SJR: 0.383, h-index: 19)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 2)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 5, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 4, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 5)
Acute Pain     Full-text available via subscription   (Followers: 13)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 6)
Additive Manufacturing     Hybrid Journal   (Followers: 7, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 22)
Advanced Cement Based Materials     Full-text available via subscription   (Followers: 3)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 137, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 17, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 9, SJR: 0.299, h-index: 15)
Advances in Agronomy     Full-text available via subscription   (Followers: 15, SJR: 2.071, h-index: 82)
Advances in Anesthesia     Full-text available via subscription   (Followers: 27, SJR: 0.169, h-index: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 3)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 6, SJR: 1.054, h-index: 35)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 11, SJR: 0.801, h-index: 26)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 22, SJR: 1.286, h-index: 49)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
Advances in Botanical Research     Full-text available via subscription   (Followers: 3, SJR: 0.619, h-index: 48)
Advances in Cancer Research     Full-text available via subscription   (Followers: 26, SJR: 2.215, h-index: 78)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 0.9, h-index: 30)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 2.139, h-index: 42)
Advances in Cell Aging and Gerontology     Full-text available via subscription   (Followers: 4)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 13)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 26, SJR: 0.183, h-index: 23)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 9, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 29, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 16, SJR: 0.223, h-index: 22)
Advances in Dermatology     Full-text available via subscription   (Followers: 12)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 12)
Advances in Digestive Medicine     Open Access   (Followers: 7)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 6)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Ecological Research     Full-text available via subscription   (Followers: 46, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 26, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 8)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 44, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 3)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 52, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 16)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 22, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 0.497, h-index: 31)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 26)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 36, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 3, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 4)
Advances in Life Course Research     Hybrid Journal   (Followers: 8, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 2)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Marine Biology     Full-text available via subscription   (Followers: 16, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 5, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 23)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 10)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 9, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 4)
Advances in Oncobiology     Full-text available via subscription   (Followers: 3)
Advances in Organ Biology     Full-text available via subscription   (Followers: 2)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 24, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 13)
Advances in Pharmacology     Full-text available via subscription   (Followers: 15, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 4)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 62)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.1, h-index: 2)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 5)
Advances in Space Research     Full-text available via subscription   (Followers: 368, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 8)
Advances in Surgery     Full-text available via subscription   (Followers: 8, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 31, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 16)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 6, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 45, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 5, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 336, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 5, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 9, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 449, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 31, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 41, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access  
Agriculture and Natural Resources     Open Access   (Followers: 3)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 56, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 5, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 11, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 8)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access   (Followers: 1)
Algal Research     Partially Free   (Followers: 8, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 4, SJR: 0.776, h-index: 35)
Alpha Omegan     Full-text available via subscription   (SJR: 0.121, h-index: 9)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 9, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 48, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 4)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 4)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 5)
American Heart J.     Hybrid Journal   (Followers: 49, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 48, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 41, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 9, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 32, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 26, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 31, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 46, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 203, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 60, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 6)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 24, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 27, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 26, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 35, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 6)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 59, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 13)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 4, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 36, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 162, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 8, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 12)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 1)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 22, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access  

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Journal Cover Actas Dermo-Sifiliograficas
  [4 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 0001-7310
   Published by Elsevier Homepage  [3118 journals]
  • Histiocitosis intralinfática, a propósito de 2 casos
    • Authors: M.E. Gómez-Sánchez; J.M. Azaña-Defez; M.L. Martínez-Martínez; M.T. López-Villaescusa
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): M.E. Gómez-Sánchez, J.M. Azaña-Defez, M.L. Martínez-Martínez, M.T. López-Villaescusa
      La histiocitosis intralinfática es un proceso benigno caracterizado por placas eritematosas mal delimitadas, a veces reticuladas, otras con nódulos o vesículas en su interior. Su etiopatogenia parece estar relacionada con procesos inflamatorios crónicos en el área afectada, cirugía previa o con enfermedades sistémicas, sobre todo con la artritis reumatoide. Presentamos 2 nuevos casos, ambos asociados a cirugía articular del área afecta y enfermedad osteoarticular (osteocondromatosis sinovial primaria y artritis reumatoide). Esta entidad tiene un comportamiento crónico y no existe un tratamiento específico. En los 2 casos presentados se plantearon distintas opciones terapéuticas, mostrando uno de ellos una respuesta espectacular al tratamiento con pentoxifilina oral junto con tacrolimus tópico. Intralymphatic histiocytosis is a benign condition characterized by poorly defined erythematous plaques (sometimes forming a reticular pattern) as well as the presence of nodules and vesicles. Its etiology and pathogenesis appear to be related to chronic inflammation in the affected area, prior surgery, or systemic disease, particularly rheumatoid arthritis. We report on 2 new cases, both associated with joint surgery in the affected area and osteoarticular disease (primary synovial osteochondromatosis and rheumatoid arthritis). This is a chronic disease and there is no specific treatment. Different treatment options were chosen in the 2 cases described. A spectacular response to treatment with oral pentoxifylline and topical tacrolimus was observed in 1 of the patients.

      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2016.07.027
       
  • La dermatitis atópica del adulto: una enfermedad impactante
    • Authors: Y. Gilaberte
      First page: 1
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): Y. Gilaberte


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.10.004
       
  • Posicionamiento de la Academia Española de Dermatología y Venereología
           sobre la teledermatología
    • Authors: D. Moreno-Ramírez; G. Romero-Aguilera; P. Pasquali; S. Vaño; L. Ríos-Buceta; J. Malvehy; R. Taberner; L. Ferrándiz
      Pages: 4 - 5
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): D. Moreno-Ramírez, G. Romero-Aguilera, P. Pasquali, S. Vaño, L. Ríos-Buceta, J. Malvehy, R. Taberner, L. Ferrándiz


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.09.004
       
  • Manejo práctico de inmunosupresores en dermatología
    • Authors: V.M. Leis-Dosil; I. Prats-Caelles
      Pages: 24 - 34
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): V.M. Leis-Dosil, I. Prats-Caelles
      Las enfermedades inflamatorias y autoinmunes constituyen un desafío terapéutico por frecuencia y complejidad. Su tratamiento se basa en la inmunosupresión del paciente con glucocorticoides, inmunosupresores ahorradores de corticoides y fármacos biológicos, siendo imprescindible por tanto conocer su manejo. Cuando se va a pautar un inmunosupresor es necesario realizar un estudio previo para detectar contraindicaciones, infecciones latentes o determinar la dosis más adecuada del fármaco. Durante el tratamiento se deben realizar controles periódicos para detectar efectos secundarios. Cada fármaco tiene un tiempo de inicio de acción que es preciso conocer, así como una duración o dosis acumulada máxima recomendada. Los dermatólogos estamos habituados al uso estos fármacos inmunosupresores, pero es necesario tener claras las pautas y los controles necesarios con cada uno, para disminuir la variabilidad y evitar efectos adversos potencialmente graves. The treatment of inflammatory and autoimmune diseases is challenging because of their frequency and complexity. Treatment of these diseases is based on the suppression of the patient's immune system using corticosteroids, corticosteroid-sparing immunosuppressive agents, and biologic drugs, making an understanding of the management of immunosuppressive therapy essential. Before an immunosuppressive agent is prescribed, a study must be carried out to identify contraindications, detect latent infections, and determine the most appropriate dose. During treatment, regular monitoring is required to detect adverse effects. The clinician must be familiar with the time lag between start of treatment and onset of the immunosuppressive effect as well as the maximum recommended duration of treatment and cumulative dose for each drug. As dermatologists we are accustomed to using these immunosuppressive agents, but we should have a good knowledge of the guidelines for their use and the monitoring required in each case if we are to reduce variability and avoid potentially serious adverse effects.

      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.05.005
       
  • Impacto económico de la dermatitis atópica en adultos: estudio de base
           poblacional (estudio IDEA)
    • Authors: A. Sicras-Mainar; R. Navarro-Artieda; J.M. Carrascosa Carrillo
      Pages: 35 - 46
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): A. Sicras-Mainar, R. Navarro-Artieda, J.M. Carrascosa Carrillo
      Objetivo Determinar el uso de los recursos y los costes de la dermatitis atópica (DA) en adultos según su gravedad y las comorbilidades asociadas en situación de práctica clínica habitual. Pacientes y métodos Se efectuó un diseño observacional retrospectivo realizado a partir de la revisión de registros de pacientes ≥18años que demandaron asistencia durante 2013-2014 en un área geográfica de Cataluña con una población de 215.634 personas. Se constituyeron 3 grupos de gravedad en función del tratamiento prescrito. Las variables evaluadas fueron el conjunto de comorbilidades, la medicación concomitante/específica; y los costes sanitarios directos/indirectos. El análisis estadístico se elaboró mediante modelos de regresión múltiple, p<0,05. Resultados Se reclutaron 6.186 sujetos con diagnóstico de DA (edad-media: 47,1años; mujeres, 61,6%). En función de la gravedad de la DA se consideraron 3 grupos; el 55,7% leve (n=3.445), el 38,2% moderada (n=2.361) y el 6,1% grave (n=380). La DA grave se asoció a la probabilidad de presentar comorbilidades (β=0,192); específicamente: asma (β=0,138), depresión (β=0,099), eventos cardiovasculares (β=0,087), obesidad (β=0,085) y hábito tabáquico (β=0,025), p<0,001. El coste ascendió a 9,3 millones de euros (costes sanitarios: 75,5%; pérdidas de productividad: 24,5%), con un promedio/unitario de 1.504euros/año. Los promedios/unitarios corregidos (ANCOVA) fueron mayores en la DA grave en comparación con la moderada y la leve (3.397 vs. 2.111 y 885 euros, respectivamente; p<0,001). Conclusiones La DA grave se asocia a una elevada utilización de recursos sanitarios y costes para el Sistema Nacional de Salud proporcional a la gravedad de la dermatosis. La comorbilidad general y el asma fueron los factores con mayor impacto asociado al coste sanitario. Objective To determine resource usage and costs associated with atopic dermatitis in adults according to severity and comorbid conditions in daily clinical practice. Patients and methods We performed an observational, retrospective study based on a review of registries of patients aged ≥18 years who sought health care in 2013 and 2014 in an area of Catalonia, Spain, with a population of 215,634 persons. We established 3 classes of severity depending on the treatment prescribed. The variables evaluated were total comorbid conditions, concomitant/specific medication, and direct/indirect health care costs. The statistical analysis was based on multiple regression models. Statistical significance was set at P <.05. Results We included 6,186 patients with a diagnosis of atopic dermatitis (mean age, 47.1 years; women, 61.6%). We established 3 groups based on severity, as follows: mild (n=3,445 [55.7%]); moderate (n=2,361 [38.2%]); and severe (n=380 [6.1%]). Severe atopic dermatitis was associated with risk of presenting comorbid conditions (β=0.192), namely, asthma (β=
      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.09.003
       
  • Correlation Between Incisional Biopsy Histological Subtype and a Mohs
           Surgery Specimen for Nonmelanoma Skin Cancer
    • Authors: E.C. Cortés-Peralta; J. Ocampo-Candiani; O.T. Vázquez-Martínez; I.M. Gutiérrez-Villarreal; I. Miranda-Maldonado; V. Garza-Rodríguez
      Pages: 47 - 51
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): E.C. Cortés-Peralta, J. Ocampo-Candiani, O.T. Vázquez-Martínez, I.M. Gutiérrez-Villarreal, I. Miranda-Maldonado, V. Garza-Rodríguez
      Background Histological diagnosis of a clinically suspected nonmelanoma skin cancer (NMSC) is recommended before treatment. For NMSC, concordance between the histological subtype of the preoperative biopsy and the excision specimen of basal cell carcinoma (BCC) has been reported to range from 10% to 81%. No large study on the concordance between NMSC histology seen in a preoperative biopsy with the following tumour specimen from Mohs micrographic surgery (MMS) has been performed in a Latin American population. Objective The aim of this study was to analyse and compare the histological subtype of the incisional biopsies reviewed by the dermatopathologist with the histological subtype of the tumour specimen obtained during MMS interpreted by the dermatopathologist and the Mohs surgeon. Methods A retrospective analysis of 320 NMSC was performed. The interobserver correlation was based on kappa values. Results The mean weighted kappa value between the preoperative NMSC biopsy and intraoperative histological subtype of the tumour specimen from MMS analysed by the Mohs surgeon and the dermatopathologist was 0.22 and 0.24, respectively. The correlation in the histologic subtype of the intraoperative tumour specimen from MMS that was interpreted by the dermatopathologist and Mohs surgeon was 0.58. Conclusions Dermatologists need to be aware of the limited value of incisional biopsies to accurately diagnose the histological subtype of a NMSC. The concordance rate in the histological diagnosis of the tumour specimens that were obtained from MMS between the Mohs surgeon and the dermatopathologist is moderate. However, the correlation is low compared with incisional biopsy subtypes.

      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.08.003
       
  • Investigación clínica en dermatología y venereología de centros e
           instituciones españolas, 2005-2014. Resultados del estudio MaINDH
    • Authors: A. Molina-Leyva; M.A. Descalzo; I. García-Doval
      Pages: 52 - 57
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): A. Molina-Leyva, M.A. Descalzo, I. García-Doval
      Antecedentes y objetivo Los artículos de investigación clínica publicados en revistas científicas y los indicadores bibliométricos que de ellos derivan son un método útil para medir la cantidad y la calidad de la investigación clínica realizada. El objetivo de este estudio es conocer la cantidad, calidad y temática de la producción científica de centros e instituciones de dermatología españoles. Material y método Estudio bibliométrico de los artículos de investigación clínica con fecha definitiva de publicación entre el año 2005 al 2014, ambos inclusive, en las bases de datos Medline o Embase, en cuya dirección de autor de correspondencia figure un centro o institución de dermatología española y que cumplan los criterios de investigación clínica en dermatología. Resultados De los 8.617 artículos encontrados, 1.104 (12,81%) cumplieron los criterios de inclusión. El principal criterio de exclusión —67,37% de los artículos— fue tener un nivel de evidencia científico mayor de 4. La revista en la que se publicaron más artículos fue Actas Dermosifiliográficas con 326 artículos (29,53%). La enfermedad con un mayor número de artículos fue el melanoma, con 134artículos (12,13%). Limitaciones El criterio para atribuir una publicación científica a una institución dermatológica española en función de la dirección del autor de la correspondencia hace que estudios en los que participan dermatólogos que trabajan en estudios dirigidos por instituciones no dermatológicas no sean incluidos. Conclusiones Solo una pequeña proporción de los artículos que publican las instituciones de dermatología españolas pueden ser considerados investigación clínica. El principal motivo es el bajo nivel de evidencia científica. La mayoría de las publicaciones son reportes de casos clínicos. Background and objective Bibliometric indicators provide a useful measure of the number of clinical research articles published in scientific journals and their quality. This study aimed to assess the amount and quality of research carried out in Spanish dermatology centers and to describe the research topics. Material and method Bibliometric study of clinical research articles that met the inclusion criteria and had a definitive publication date between 2005 and 2014 in MEDLINE or Embase in which the corresponding author's affiliation was a Spanish hospital dermatology department or other center. Results Of 8,617 articles found, 1,104 (12.81%) met the inclusion criteria. The main reason for excluding articles was that they did not have an evidence level of 4 or better. The main vehicle for reporting was the journal Actas Dermosifiliográficas, which published 326 articles (29.53%). Melanoma, the disease the researchers studied most often, accounted for 134 articles (12.13%). Limitations A limitation to bear in mind when interpreting the results is that we relied ...
      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.07.008
       
  • Estudio observacional de seguridad, prospectivo y unicéntrico para
           determinar la capacidad alergogénica de Mercromina Film® y otros
           antisépticos de uso común en pacientes con dermatitis de contacto
    • Authors: S. Baltà Cruz; N. Moreno Ribera; M.T. Estrach Panella
      Pages: 58 - 62
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): S. Baltà Cruz, N. Moreno Ribera, M.T. Estrach Panella
      Introducción Pese al uso tan extendido de la Mercromina Film® y otros antisépticos de uso tópico, estos no se encuentran incluidos en la serie estándar española del Grupo Español de Investigación en Dermatitis de Contacto y Alergia Cutánea, realizada ante sospecha de dermatitis alérgica de contacto. Además, no existen estudios recientes sobre capacidad alergogénica de la merbromina, motivo por el que se plantea la presente investigación. Objetivo Determinar la capacidad alergénica de la merbromina y compararla con la de los otros antisépticos de uso tópico frecuentemente utilizados en la práctica clínica, entre los que se incluye la povidona iodada, clorhexidina y eosina. Material y métodos Estudio observacional de seguridad, prospectivo y unicéntrico realizado en 105 pacientes con sospecha de dermatitis alérgica de contacto que acudieron a la consulta del departamento de dermatología. Resultados El 1,9% de los participantes presentó dermatitis alérgica de contacto a la merbromina. El 12,4% de los pacientes presentó sensibilización ante la povidona iodada. Las diferencias entre el porcentaje de pacientes que presentó dermatitis alérgica de contacto a Betadine® solución dérmica respecto al resto de antisépticos fueron estadísticamente significativas (prueba de McNemar; p<0,05). No se registraron efectos adversos con ninguno de los antisépticos en estudio. Conclusiones Mercromina Film ha demostrado una muy baja capacidad alergénica en la prueba de patch test. Cuando se comparan con otros antisépticos tópicos, la mayor capacidad alergénica se encontró con la povidona iodada. Introduction Although Mercromina Film and other topical antiseptics are widely used, they are not included in the standard series recommended by the Spanish Contact Dermatitis and Skin Allergy Research Group for testing suspected allergic contact dermatitis (ACD). Furthermore, no recent studies have investigated the allergenic potential of merbromin. Objective To determine the allergenic potential of merbromin and compare it with that of other topical antiseptics widely used in clinical practice, including povidone-iodine, chlorhexidine, and eosin. Material and methods Prospective single-center observational safety study of 105 patients with suspected ACD seen at the dermatology department of our hospital. Results Of the 105 patients studied, 1.9% had a positive patch test to merbromin and 12.4% were sensitized to povidone-iodine. The differences in the proportion of patients with ACD to Betadine Solución Dérmica (povidone-iodine) compared with the rest of the antiseptics was statistically significant (McNemar test, P<.05). No adverse reactions were observed in any of the patients.
      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.06.013
       
  • Tumoración en cuero cabelludo de gran tamaño de larga evolución con
           adenopatías ipsilaterales
    • Authors: A. Hermosa-Gelbard; C. Moreno García del Real; S. Vañó-Galván
      Pages: 63 - 64
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): A. Hermosa-Gelbard, C. Moreno García del Real, S. Vañó-Galván


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2016.10.020
       
  • Lesiones seudoverrugosas vulvares de reciente aparición
    • Authors: L. Padilla-España; J. Bosco Repiso-Jiménez; C. Abitei
      Pages: 65 - 66
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): L. Padilla-España, J. Bosco Repiso-Jiménez, C. Abitei


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2016.07.026
       
  • Pápula rosada de crecimiento lento
    • Authors: J.L. Ramírez-Bellver; S. Saenz Guirado
      Pages: 67 - 68
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): J.L. Ramírez-Bellver, S. Saenz Guirado


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.06.011
       
  • FR-Luces y sombras de nuevos fármacos en el tratamiento de la
           alopecia areata
    • Authors: D. Morgado-Carrasco; E. Rodríguez-Lobato; J. Riera-Monroig; J. Ferrando
      Pages: 69 - 70
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): D. Morgado-Carrasco, E. Rodríguez-Lobato, J. Riera-Monroig, J. Ferrando


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.05.003
       
  • Colgajo de keystone tipo i
    • Authors: H.A. Cocunubo-Blanco; A. Pérez-Bustillo; E. Manrrique; M.Á. Rodríguez-Prieto
      Pages: 71 - 72
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): H.A. Cocunubo-Blanco, A. Pérez-Bustillo, E. Manrrique, M.Á. Rodríguez-Prieto


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.05.015
       
  • Un tumor rosado, hiperplasia angiolinfoide con eosinofilia
    • Authors: I. Pérez-López; A. Martínez-López; P. Aguayo-Carreras; M.J. Naranjo-Díaz
      First page: 73
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): I. Pérez-López, A. Martínez-López, P. Aguayo-Carreras, M.J. Naranjo-Díaz


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2016.10.022
       
  • Male breast cancer mimicking melanoma
    • Authors: T. Kueder Pajares; A.J. García Malinis; P. Manchado López
      First page: 74
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): T. Kueder Pajares, A.J. García Malinis, P. Manchado López


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2016.12.016
       
  • Infiltración cutánea por macroglobulinemia de Waldenström
    • Authors: S. Oscoz-Jaime; A.D. Agulló-Pérez; C. Llanos-Chavarri; J.I. Yanguas-Bayona
      Pages: 75 - 78
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): S. Oscoz-Jaime, A.D. Agulló-Pérez, C. Llanos-Chavarri, J.I. Yanguas-Bayona


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.04.021
       
  • Lupus eritematoso con afectación genital: una localización
           inusual
    • Authors: E. del Alcázar-Viladomiu; A. López-Pestaña; A. Tuneu-Valls
      Pages: 78 - 80
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): E. del Alcázar-Viladomiu, A. López-Pestaña, A. Tuneu-Valls


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.05.010
       
  • Acantomas epidermolíticos múltiples del escroto: lo que el
           prurito genital puede esconder
    • Authors: P. García-Martínez; L. Curto-Barredo; R. Rovira-López; R.M. Pujol
      Pages: 81 - 82
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): P. García-Martínez, L. Curto-Barredo, R. Rovira-López, R.M. Pujol


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.03.017
       
  • Prevalence of Actinic Keratosis in Different Regions of Spain: The EPIQA
           Study
    • Authors: C. Ferrándiz-Pulido; M. Lera-Imbuluzqueta; C. Ferrándiz; M.J. Plazas-Fernandez
      Pages: 83 - 86
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): C. Ferrándiz-Pulido, M. Lera-Imbuluzqueta, C. Ferrándiz, M.J. Plazas-Fernandez


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.05.014
       
  • Morfea y liquen escleroatrófico extragenital generalizados tras
           vacuna antigripal
    • Authors: S. Requena López; Y. Hidalgo García; S. Gómez Díez; B. Vivanco Allende
      Pages: 86 - 88
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): S. Requena López, Y. Hidalgo García, S. Gómez Díez, B. Vivanco Allende


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.05.016
       
  • Nevus azul subungueal
    • Authors: C. Fachal; L.C. Pérez-Pérez; F. Allegue; S. Calviño
      Pages: 88 - 90
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): C. Fachal, L.C. Pérez-Pérez, F. Allegue, S. Calviño


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.03.018
       
  • The Possible Combined Action of Different Trigger Agents in Rosacea
    • Authors: G. Ciccarese; A. Parodi; A. Rebora; F. Drago
      Pages: 91 - 92
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): G. Ciccarese, A. Parodi, A. Rebora, F. Drago


      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.07.013
       
  • Ampliando el perfil genético del síndrome de Hay-Wells
    • Abstract: Publication date: Available online 9 January 2018
      Source:Actas Dermo-Sifiliográficas
      Author(s): D. Romero-Pérez, B. Encabo-Durán, R. Ramón-Sapena


      PubDate: 2018-01-10T08:49:36Z
       
  • Pápulas violáceas sobre mácula acrómica
    • Authors: Burgos
      Abstract: Publication date: Available online 6 January 2018
      Source:Actas Dermo-Sifiliográficas
      Author(s): A. Imbernón-Moya, F. Burgos, M.Á. Gallego-Valdés


      PubDate: 2018-01-10T08:49:36Z
       
  • Eritema postimplantación asociado a implante mamario tratado con láser
           de colorante pulsado
    • Abstract: Publication date: Available online 5 January 2018
      Source:Actas Dermo-Sifiliográficas
      Author(s): A. Alegre-Sánchez, D. Buendía-Castaño, P. Fernández-González, B. Pérez-García


      PubDate: 2018-01-10T08:49:36Z
       
  • La bibliometría como herramienta de conocimiento de la situación de la
           investigación clínica española en dermatología y sus implicaciones
           futuras
    • Authors: Romero
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): I. Belinchón Romero


      PubDate: 2018-01-03T06:25:00Z
       
  • Dermatitis de contacto a antisépticos tópicos. ¿Qué posición ocupa la
           Mercromina Film®'
    • Authors: F.J.
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): F.J. Navarro-Triviño


      PubDate: 2018-01-03T06:25:00Z
       
  • Tratamiento de las neoplasias anexiales cutáneas malignas
    • Authors: Requena
      Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): C. Bernárdez, L. Requena
      Las neoplasias anexiales cutáneas malignas constituyen un grupo de carcinomas poco frecuentes, habitualmente de bajo grado de malignidad, que muestran diferenciación folicular, sebácea, apocrina o ecrina o una combinación de las 3 primeras. Clínicamente suelen ser neoplasias con características poco distintivas, siendo necesaria una biopsia que permitirá establecer el tipo de diferenciación y el diagnóstico definitivo. Al tratarse de una enfermedad poco frecuente, no existe un claro consenso sobre el tratamiento más eficaz. En la mayoría de casos se considera la microcirugía de Mohs como la opción más efectiva para prevenir recidivas. La radioterapia y quimioterapia han sido escasamente estudiadas y solo se han mostrado eficaces en escasas ocasiones. Malignant cutaneous adnexal neoplasms form a group of rare, typically low-grade-malignancy carcinomas with follicular, sebaceous, apocrine, or eccrine differentiation or a combination of the first 3 subtypes. Their clinical presentation is usually unremarkable, and biopsy is required to establish the differentiation subtype and the definitive diagnosis. Due to their rarity, no clear consensus has been reached on which treatment is most effective. Mohs micrographic surgery is considered to be the best option to prevent recurrence in the majority of patients. Radiotherapy and chemotherapy have been studied in very few cases and have rarely been shown to be effective.
      Graphical abstract image

      PubDate: 2018-01-03T06:25:00Z
       
  • Reply To: The Possible Combined Action of Different Trigger Agents in
           Rosacea
    • Abstract: Publication date: January–February 2018
      Source:Actas Dermo-Sifiliográficas, Volume 109, Issue 1
      Author(s): Á. Hernández-Martín


      PubDate: 2018-01-03T06:25:00Z
       
  • Photodynamic Therapy Interventions in Facial Photodamage: A Systematic
           Review
    • Authors: G. Sanclemente; V. Ruiz-Cañas; J.M. Miranda; A.P. Ferrín; P.A. Ramirez; G.N. Hernandez
      Abstract: Publication date: Available online 30 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): G. Sanclemente, V. Ruiz-Cañas, J.M. Miranda, A.P. Ferrín, P.A. Ramirez, G.N. Hernandez
      Introduction Photodynamic therapy (PDT) involves the combination of a light source and a photosensitizing agent to induce tissue damage via the generation of singlet oxygen. Although topical PDT has been approved for other indications, its use in facial photodamage is uncertain. Aims To assess the efficacy and safety of PDT in facial skin photoaging. Methods All randomized clinical trials (RCTs) evaluating the efficacy and safety of any form of topical PDT for the treatment of facial photodamage (dermatoheliosis) or photoaging in patients older than 18 years, were included. Photodynamic-therapy using any topical photosensitizing agent at any dose, and with any light-source, were considered. Comparators were chemical exfoliation, intense pulsed light (IPL), light emitting diodes (LED), dermabrasion or microdermabrasion, ablative or non-ablative lasers, injectables, surgery, placebo and/or no treatment. A systematic search in PubMed, Embase, Lilacs, Google Scholar and RCT's registry databases, was performed. Results Search was conducted up to May 4th 2016. Four authors independently selected and assessed methodological quality of each RCT. According to inclusion criteria, twelve studies were included (6 aminolevulinate (ALA) trials and 6 methyl aminolevulinate (MAL) trials), but the majority of them had methodological constraints particularly in randomization description and patients/outcome assessors blindness. Discussion and conclusions Overall results indicated that PDT either with ALA or with MAL was effective and safe for facial photodamage treatment, but high quality of evidence was found mainly for MAL studies.
      Graphical abstract image

      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.05.021
       
  • El futuro del tratamiento de las malformaciones capilares
    • Authors: del
      Abstract: Publication date: Available online 29 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): R. del Río


      PubDate: 2018-01-03T06:25:00Z
       
  • Reconstructive methods in Mohs micrographic surgery in Uruguay: A
           bidirectional descriptive cohort analysis
    • Authors: J. Navarrete; J. Magliano; M. Martínez; C. Bazzano
      Abstract: Publication date: Available online 14 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): J. Navarrete, J. Magliano, M. Martínez, C. Bazzano
      Background and objectives The primary goal of Mohs micrographic surgery (MMS) is to completely excise a cancerous lesion and a wide range of reconstructive techniques of varying complexity are used to close the resulting wound. In this study, we performed a descriptive analysis of patients who underwent MMS, with a focus on wound closure methods. Material and methods We conducted a bidirectional descriptive cohort analysis of all MMS procedures performed by a single surgeon between November 2013 and April 2016. Cosmetic outcomes were photographically assessed by a dermatologist after a minimum follow-up of 90 days. Results We analyzed 100 MMS procedures in 71 patients with a median age of 73 years. The tumors were basal cell carcinoma (70%), squamous cell carcinoma (29%), and dermatofibrosarcoma protuberans (1%); 75% were located on the head and neck. The reconstructive techniques used were flap closure (48%), simple closure (36%), closure by second intention (11%), and other (5%). Cosmetic outcomes were assessed for 70 procedures (47 patients) and the results were rated as excellent in 20% of cases, very good in 40%, good in 20%, moderate in 17%, and bad/very bad in 2.9%. No significant associations were observed between cosmetic outcome and sex, Fitzpatrick skin type, hypertension, diabetes mellitus, or smoking. Worse outcomes, however, were significantly associated with larger tumor areas and defects, location on the trunk, and flap and second-intention closure. Conclusions Although there was a tendency to use simple wound closure for lesions located on the trunk and surgical defects of under 4.4cm2, the choice of reconstructive technique should be determined by individual circumstances with contemplation of clinical and tumor-related factors and the preference and experience of the surgeon.
      Graphical abstract image

      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.10.007
       
  • ¿Qué procedimientos diagnósticos deberíamos realizar ante una sospecha
           de reacción alérgica a un tatuaje' Propuesta basada en nuestra
           casuística
    • Authors: I. González-Villanueva; J.F. Silvestre Salvador
      Abstract: Publication date: Available online 6 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): I. González-Villanueva, J.F. Silvestre Salvador
      Introducción Los tatuajes se han convertido en una práctica muy popular en los países occidentales, sobre todo entre los más jóvenes. Las complicaciones asociadas a esta técnica incluyen procesos infecciosos, alérgicos, reacciones a cuerpo extraño e incluso procesos inflamatorios sistémicos. Pacientes y métodos Se ha realizado un estudio retrospectivo de todos los pacientes que acudieron a la consulta de Alergia cutánea por manifestar complicaciones en un tatuaje desde enero de 2002 a diciembre de 2016. Resultados Se han incluido a 23 pacientes. De ellos, 9 presentaron complicaciones de forma precoz y en todos ellos la etiología fue infecciosa. De los 14 pacientes con reacciones tardías, 10 fueron diagnosticados de probable dermatitis de contacto alérgica a la tinta, sin embargo solo en 3 de los casos se pudo apuntar al alérgeno probablemente culpable y tan solo en uno de ellos se pudo demostrar. Se detectaron dos casos de sarcoidosis cutánea, uno de reacción granulomatosa a cuerpo extraño, y un caso de reacción neuropática en una paciente. Conclusiones Las complicaciones asociadas a los tatuajes son un motivo de consulta relativamente frecuente en las consultas de Dermatología. Proponemos un algoritmo diagnóstico basado en nuestra casuística, que ayude a orientar las distintas reacciones a tatuaje y con ello a iniciar las medidas terapéuticas oportunas. Introduction Tattooing has become a popular practice in western countries, particularly among younger populations. Tattoos, however, can cause complications, such as infections, allergic or foreign-body reactions, and even systemic inflammatory responses. Patients and methods We conducted a retrospective study of all patients seen for tattoo-related complications at our skin allergy unit between January 2002 and December 2016. Results We studied 23 patients. Nine of these experienced early complications, all related to infection. The other 14 patients developed late reactions. Ten were diagnosed with probable allergic contact dermatitis to ink, but the suspect allergen was identified in just 3 cases and confirmed in just 1 of these. There were 2 cases of cutaneous sarcoidosis, 1 case of foreign body granuloma, and 1 case of neuropathy. Conclusions Complications resulting from tattoos are relatively common dermatology complaints. Drawing from our experience, we propose a diagnostic algorithm designed to guide dermatologists in evaluating different reactions to tattoos and prescribing appropriate treatment.
      Graphical abstract image

      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.10.006
       
  • La investigación clínica en las secciones territoriales de la Academia
           Española de Dermatología y Venereología (AEDV)
    • Authors: Á. Iglesias-Puzas; A. Batalla; Á. Flórez
      Abstract: Publication date: Available online 6 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): Á. Iglesias-Puzas, A. Batalla, Á. Flórez
      Introducción La investigación clínica (IC) se centra en el estudio de los pacientes para mejorar su atención. Nuestro objetivo fue conocer qué porcentaje de las comunicaciones presentadas a las reuniones de tres secciones territoriales de la AEDV cumplen criterios de IC, su nivel de evidencia y su evolución temporal. Material y métodos Se revisaron las comunicaciones científicas de las reuniones territoriales gallega, astur-cántabro-castellano-leonesa (ACL) y andaluza publicadas en los suplementos de la revista Actas Dermo-Sifiliográficas (años 2000-2015). Utilizando una definición de IC previamente validada, se estableció cuáles de los resúmenes se ajustaban a dicha definición, se determinó su nivel de evidencia y la evolución temporal del porcentaje de estudios de investigación. Resultados De las 1.188 comunicaciones analizadas, el 29,6% cumplieron criterios de IC. La mayoría correspondían a un nivel de evidencia4 (95,2%), distribuidos en un 44,2% de estudios transversales y un 55,8% de series de casos. La prevalencia de la IC en las secciones gallega, ACL y andaluza fue del 26,6% (94,7%, nivel 4), del 22,7% (97,6%, nivel 4) y del 37,2% (94,3%, nivel 4), respectivamente. El porcentaje de trabajos de IC aumentó significativamente a lo largo de los años. Conclusiones La IC representa el 29,6% de las comunicaciones en las reuniones evaluadas. La mayoría de los trabajos corresponden a series de casos y estudios transversales. Los territorios estudiados muestran diferencias en cuanto al porcentaje de IC, pero siguen una distribución similar de los niveles de evidencia. En el periodo de tiempo evaluado, el porcentaje de comunicaciones sobre IC se ha incrementado. Introduction Clinical research is the study of patients with the aim of improving care. Our objectives were to calculate the percentage of presentations at territorial section meetings of the Spanish Academy of Dermatology and Venereology (AEDV) that described clinical research, to assess the level of evidence the research provided, and to analyze change in clinical research volume over time. Material and methods We reviewed supplements of the journal Actas Dermo-Sifiliográficas for 2000 through 2015 that contained abstracts of presentations given at the AEDV section meetings in Galicia; the area comprising Asturias, Cantabria, and Castile-Leon (ACCL); and Andalusia. We selected abstracts that met a previously validated definition of clinical research and categorized each according to level of evidence. We also analyzed how the weight of clinical research presentations changed over time. Results Of the total of 1,188 presentations, 29.6% met the criteria that defined clinical research. Most provided level-4 evidence (95.2%); 44.2% of those presentations reported cross-sectional studies and 55.8% analyzed case series. Clinical research accounted for 26.6% of the presentations in Galicia (94.7% of them, level 4), 22.7% of those at the ACCL meeting (97.6%, level 4), and 37.2% of those in Andalusia (94.3%, level 4). The proportion of clinical research increased significantly over the years studied. Conclusions Clinical research accounted for 29.6% of the communications presented at the meetings we reviewed. Most of these presentations concerned case series or cross-secti...
      PubDate: 2018-01-03T06:25:00Z
      DOI: 10.1016/j.ad.2017.10.001
       
  • Fenómeno de Koebner en el síndrome de Sweet
    • Authors: T. Hiraiwa; M. Ishikawa; T. Ohashi; T. Miura; M. Satoh; T. Yamamoto
      Abstract: Publication date: Available online 23 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): T. Hiraiwa, M. Ishikawa, T. Ohashi, T. Miura, M. Satoh, T. Yamamoto


      PubDate: 2017-12-27T06:20:12Z
      DOI: 10.1016/j.ad.2017.06.022
       
  • Tratamiento de la enfermedad de injerto contra huésped crónica
           esclerodermiforme con imatinib: una perspectiva dermatológica
    • Authors: P. Molés-Poveda; P. Montesinos; J. Sanz-Caballer; B. de Unamuno; J.L. Piñana; A. Sahuquillo; R. Botella-Estrada
      Abstract: Publication date: Available online 15 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): P. Molés-Poveda, P. Montesinos, J. Sanz-Caballer, B. de Unamuno, J.L. Piñana, A. Sahuquillo, R. Botella-Estrada
      Introducción La enfermedad de injerto contra huésped crónica (EICHc) es la causa más importante de mortalidad tardía no relacionada con la recidiva del trasplante alogénico de células progenitoras hematopoyéticas. La EICHc esclerodermiforme suele ser refractaria a los corticosteroides y supone todo un reto terapéutico. Se han descrito anticuerpos activadores contra el RFCDP en pacientes con EICHc esclerodermiforme. Estos anticuerpos inducen la fosforilación del RFCDP, produciendo fibrosis. Hay cada vez más evidencias de la efectividad de imatinib, un inhibidor de la tirosina cinasa, en el tratamiento de la EICHc esclerodermiforme. Objetivo Evaluar la respuesta de la EICHc esclerodermiforme al imatinib. Materiales y métodos Estudio retrospectivo de 18 pacientes con EICHc cutánea esclerodermiforme refractaria a inmunosupresores tratada con imatinib en un único centro. La evaluación de la respuesta al tratamiento se realizó mediante valoración clínica del dermatólogo y percepción subjetiva del paciente tras uno, 3, 6, 9, 12 y 18 meses de iniciar el tratamiento con imatinib. La respuesta fue valorada como completa, parcial, significativa, sin cambios o progresión. El descenso de la dosis de esteroides se catalogó como completo, parcial o no posible. Resultados En nuestra serie, 4 (22%) pacientes lograron una respuesta completa, 9 (50%) alcanzaron una respuesta parcial, 2 (11%) tuvieron un grado significativo de respuesta, 2 (11%) no presentaron ningún cambio y uno (6%) experimentó avance de la enfermedad en el último seguimiento que se llevó a cabo. El tiempo medio transcurrido desde el inicio del imatinib hasta mostrar algún grado de respuesta fue de 2,75 meses (rango 1-9 meses). Conclusiones Este estudio apoya la evidencia de la utilidad del imatinib en el tratamiento de la EICHc esclerodermiforme. Introduction Chronic graft-versus-host disease (cGVHD) is the most important cause of late non-relapse mortality after allogeneic hematopoietic stem cell transplantation. Sclerodermatous cGVHD is usually steroid refractory and remains a therapeutic challenge. Activating antibodies against the PDGFR have been reported in patients with sclerodermatous cGVHD. These antibodies induce PDGFR phosphorylation and lead to fibrosis. There is increasing evidence of successful treatment of sclerodermatous cGVHD with imatinib, a tyrosine kinase inhibitor. Objective To evaluate the response of cutaneous sclerodermatous cGVHD to imatinib. Materials and methods Retrospective study of 18 patients with sclerodermatous cGVHD refractory to immunosuppressants treated with imatinib in a single center. Evaluation of treatment response was performed by clinicians’ assessment and patients’ subjective response at one, 3, 6, 9, 12 and 18 months after initiation of imatinib. Response was assessed as complete, partial, significant, no change or progression. Tapper off steroids was complete, partial or not possible. Results In our series, 4 (22%) patients a...
      PubDate: 2017-12-22T06:17:27Z
      DOI: 10.1016/j.ad.2017.11.003
       
  • Morfea en la infancia: actualización
    • Authors: Aranegui
      Abstract: Publication date: Available online 14 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): B. Aranegui, J. Jiménez-Reyes
      La morfea es una enfermedad de la piel que se manifiesta en forma de inflamación y fibrosis. En niños y jóvenes, también se conoce como esclerodermia juvenil localizada. En edad infantil, afecta con mayor frecuencia al sexo femenino y la edad de comienzo se ha establecido en torno a los 5-7 años. Una clasificación reciente divide la morfea en: circunscrita (en placas), lineal, generalizada, panesclerótica y mixta. Alrededor de un 40% de los pacientes presentan manifestaciones extracutáneas. Los tratamientos empleados en morfea infantil son: fototerapia, calcitriol oral, calcipotriol tópico, tacrolimus 0,1% tópico, metotrexato, glucocorticoides tópicos y sistémicos, mofetil micofenolato, bosentán e imiquimod 5% tópico. Diversas medidas de resultado pueden ayudar a monitorizar el tratamiento. Los estudios pronósticos son escasos, pero apuntan hacia una enfermedad con tendencia a un curso crónico o intermitente-recurrente y una frecuencia considerable de secuelas. Morphea is an inflammatory, fibrosing skin disorder. When it occurs in childhood, it is also known as localized juvenile scleroderma. It is more common in girls and typically appears around the age of 5 to 7 years. According to a recent classification system, morphea is divided into 5 types: circumscribed (plaque), linear, generalized, pansclerotic, and mixed. Approximately 40% of patients present extracutaneous manifestations. Childhood morphea is treated with phototherapy, oral or topical calcitriol, topical tacrolimus 0.1%, methotrexate, topical or systemic corticosteroids, mycophenolate mofetil, bosentán, and topical imiquimod 5%. A variety of measuring tools are used to monitor response to treatment. Few prognostic studies have been conducted, but findings to date suggest that the disease tends to run a chronic or intermittent-recurrent course and frequently causes sequelae.
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      PubDate: 2017-12-22T06:17:27Z
       
  • Pitiriasis versicolor atrófica
    • Authors: F. Allegue; C. Fachal; D. González-Vilas; A. Zulaica
      Abstract: Publication date: Available online 14 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): F. Allegue, C. Fachal, D. González-Vilas, A. Zulaica


      PubDate: 2017-12-22T06:17:27Z
      DOI: 10.1016/j.ad.2017.08.013
       
  • La investigación clínica en la Academia Española de Dermatología y
           Venereología vista desde su corazón
    • Authors: M.A. Descalzo
      Abstract: Publication date: Available online 14 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M.A. Descalzo


      PubDate: 2017-12-22T06:17:27Z
      DOI: 10.1016/j.ad.2017.11.007
       
  • Tratamiento con imiquimod al 5% durante 12 días para las queratosis
           actínicas: estudio de la eficacia y la reacción local
    • Authors: C. Serra-Guillén; E. Nagore; B. Llombart; O. Sanmartín; C. Requena; L. Calomarde; C. Guillén
      Abstract: Publication date: Available online 12 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): C. Serra-Guillén, E. Nagore, B. Llombart, O. Sanmartín, C. Requena, L. Calomarde, C. Guillén
      Introducción y objetivos El imiquimod es un excelente tratamiento para las queratosis actínicas, sin embargo, su pauta prolongada de 4 semanas y la reacción local que produce pueden limitar su utilización. Los objetivos del estudio son demostrar la eficacia del imiquimod al 5% para las queratosis actínicas aplicado en una pauta continuada de 12 días y correlacionar el grado de reacción local con la eficacia. Pacientes y métodos Se incluyeron pacientes con al menos 8 queratosis actínicas que se trataron con imiquimod en crema al 5% durante 12 días seguidos. Se evaluó la reacción local como leve, moderada o intensa. El estudio estadístico de la correlación entre la reacción local y la respuesta clínica se realizó con la prueba χ2 de Pearson y el test de correlación rho de Spearman. Resultados Un total de 65 pacientes completaron el estudio. Se obtuvo un 52,3% de respuestas completas y un 75,4% de respuestas parciales. Encontramos una asociación estadísticamente significativa entre el grado de reacción local y la respuesta al tratamiento tanto en la prueba χ2 de Pearson como en el test de correlación rho de Spearman. Conclusiones La pauta continuada de imiquimod al 5% aplicado durante 12 días es eficaz para el tratamiento de las queratosis actínicas. El grado de reacción local durante el tratamiento se correlaciona con la respuesta clínica. Introduction and objectives Imiquimod is an excellent option for patients with actinic keratosis, although its use may be limited by the long course of treatment required (4 weeks) and the likelihood of local skin reactions. The objectives of the present study were to demonstrate the effectiveness of a 12-day course of imiquimod 5% for the treatment of actinic keratosis and to examine the association between treatment effectiveness and severity of local reactions. Patients and methods We included patients with at least 8 actinic keratoses treated with imiquimod 5% cream for 12 consecutive days. Local reactions were classified as mild, moderate, or severe. The statistical analysis of the association between local reactions and clinical response was based on the Pearson χ2 test and the Spearman rank correlation test. Results Sixty-five patients completed the study. Complete response was recorded in 52.3% and partial response in 75.4%. We found a statistically significant association between severity of the local reaction and response to treatment in both the Pearson χ2 test and the Spearman rank correlation test. Conclusions A 12-day course of imiquimod 5% proved effective for the treatment of actinic keratosis. Severity of local reactions during treatment was correlated with clinical response.
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      PubDate: 2017-12-22T06:17:27Z
      DOI: 10.1016/j.ad.2017.10.008
       
  • Larva migrans cutánea facial de origen autóctono en España
    • Authors: C. Durán-Vian; I. Vilanova-Udaniz; B. Castro-Gutierrez; M.A. González-López
      Abstract: Publication date: Available online 11 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): C. Durán-Vian, I. Vilanova-Udaniz, B. Castro-Gutierrez, M.A. González-López


      PubDate: 2017-12-12T06:10:24Z
      DOI: 10.1016/j.ad.2017.09.017
       
  • Leiomiosarcoma cutáneo: la importancia de la localización
           histológica
    • Authors: Llombart
      Abstract: Publication date: Available online 9 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): B. Llombart


      PubDate: 2017-12-12T06:10:24Z
       
  • Epidermólisis bullosa distrófica recesiva y embarazo
    • Authors: F. Boria; R. Maseda; M. Martín-Cameán; M. De la Calle; R. de Lucas
      Abstract: Publication date: Available online 6 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): F. Boria, R. Maseda, M. Martín-Cameán, M. De la Calle, R. de Lucas
      La epidermólisis bullosa distrófica es una enfermedad hereditaria rara debida a mutaciones del gen COL7A1. Su variante recesiva (EBDR) se caracteriza por una marcada disminución o ausencia completa de colágeno tipo VII (C7), que da lugar a una marcada fragilidad de la piel y las mucosas, desencadenando la formación de ampollas de forma espontánea o en respuesta a mínimos traumatismos. Son muy pocos los casos descritos en la literatura de esta enfermedad en embarazadas. Exponemos 2 casos de gestantes, ambas afectadas de EBDR, y su manejo en nuestra Unidad de Obstetricia de Alto Riesgo del Hospital Universitario La Paz. En ambos casos se realizó una cesárea a término, finalizando la gestación sin complicaciones mayores para la madre o el feto. A pesar de relacionarse con un mayor número de complicaciones maternas, la EBDR no representa una contraindicación para la gestación, y con un control adecuado, estas pacientes pueden ver su deseo genésico cumplido. Dystrophic epidermolysis bullosa is a rare inherited disease caused by mutations in the COL7A1 gene. Its recessive variant (recessive dystrophic epidermolysis bullosa) is characterized by the absence or considerably reduced expression of type VII collagen, which leads to marked fragility of the skin and mucous membranes and subsequent blister formation, whether spontaneously or following minimal injury. There have been very few reports of this disease in pregnant women. We present 2 cases of pregnant women with recessive dystrophic epidermolysis bullosa managed in our High-Risk Pregnancy Unit at Hospital Universitario La Paz, Madrid, Spain. Both patients underwent full-term cesarean delivery, with no further complications for mother or child. Although recessive dystrophic epidermolysis bullosa increases the risk of maternal complications, a patient is not advised against pregnancy. With adequate monitoring, these patients can fulfil their desire to become mothers.
      Graphical abstract image

      PubDate: 2017-12-12T06:10:24Z
      DOI: 10.1016/j.ad.2017.06.024
       
  • Presentación atípica de infección por virus de herpes simple tipo ii
           (VHS II) refractaria a tratamiento con aciclovir en 2 pacientes
           hematológicos
    • Authors: D. Nieto Rodríguez; E. Sendagorta Cudós; J.M. Rueda Carnero; P. Herranz Pinto
      Abstract: Publication date: Available online 6 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): D. Nieto Rodríguez, E. Sendagorta Cudós, J.M. Rueda Carnero, P. Herranz Pinto
      Las infecciones por virus herpes presentan una frecuencia no desdeñable en pacientes hematológicos. El primer caso corresponde a una paciente con leucemia linfática crónica con un herpes genital extenso refractario a aciclovir, con respuesta parcial a foscarnet que hubo que suspender por efectos secundarios sistémicos. El segundo caso es el de una paciente con un linfoma de Hodgkin folicular que presentaba un herpes hipertrófico refractario a tratamiento con aciclovir, que respondió a cidofovir intralesional e imiquimod tópico. Los pacientes hematológicos, al igual que otros enfermos inmunodeprimidos, pueden presentar manifestaciones atípicas de infección por virus herpes, así como resistencia a los tratamientos que actúan por medio de la timidina quinasa viral. Esto hace necesario tener una alta sospecha clínica para poder alcanzar un diagnóstico precoz, y conocer los diferentes tratamientos alternativos disponibles. Herpesvirus infections are not uncommon in hematologic patients. Our first patient, diagnosed with chronic lymphatic leukemia, presented extensive genital herpes infection refractory to treatment with acyclovir and with a partial response to foscarnet, which had to be withdrawn due to systemic adverse effects. The second patient, diagnosed with follicular Hodgkin lymphoma, presented hypertrophic herpes infection refractory to treatment with acyclovir but that responded to intralesional cidofovir and topical imiquimod. As in other immunodepressed patients, herpesvirus infection in hematologic patients can present atypical manifestations, as well as resistance to treatments that act via the viral thymidine kinase. A high level of clinical suspicion is therefore needed to make an early diagnosis, together with extensive knowledge of the different treatments available.
      Graphical abstract image

      PubDate: 2017-12-12T06:10:24Z
      DOI: 10.1016/j.ad.2017.09.009
       
  • Proceso de traducción y adaptación cultural de instrumentos de
           medición en salud
    • Authors: S. Ortiz-Gutiérrez; A. Cruz-Avelar
      Abstract: Publication date: Available online 6 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): S. Ortiz-Gutiérrez, A. Cruz-Avelar


      PubDate: 2017-12-12T06:10:24Z
      DOI: 10.1016/j.ad.2017.09.012
       
  • Búsqueda de nuevas pautas terapéuticas de imiquimod 5% para el
           tratamiento de las queratosis actínicas
    • Authors: R. Salido Vallejo
      Abstract: Publication date: Available online 6 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): R. Salido Vallejo


      PubDate: 2017-12-12T06:10:24Z
      DOI: 10.1016/j.ad.2017.11.005
       
  • Un caso de poroqueratosis diseminada eruptiva en un paciente oncológico
           tratado con trastuzumab y exemestano: ¿fenómeno asociado al cáncer o
           inducido por fármacos'
    • Authors: C. Mangas; V. Espeli; R. Blum
      Abstract: Publication date: Available online 6 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): C. Mangas, V. Espeli, R. Blum


      PubDate: 2017-12-12T06:10:24Z
      DOI: 10.1016/j.ad.2017.07.021
       
  • Pitiriasis liquenoide y varioliforme aguda asociada al virus herpes humano
           tipo 7
    • Authors: M. Costa-Silva; A. Calistru; J. Sobrinho-Simões; C. Lisboa; F. Azevedo
      Abstract: Publication date: Available online 6 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M. Costa-Silva, A. Calistru, J. Sobrinho-Simões, C. Lisboa, F. Azevedo
      Tanto la pitiriasis liquenoide y varioliforme aguda como la pitiriasis liquenoide crónica representan 2 extremos de un espectro de enfermedad de etiología desconocida. En este trabajo se describen 2 casos de pitiriasis liquenoide y varioliforme aguda, en los que se detectó ADN de virus herpes humano tipo 7 en muestras de piel mediante la metodología de reacción en cadena de la polimerasa, una asociación no descrita previamente. Este manuscrito puede apoyar la participación de la infección viral en la etiopatogenia de esta enfermedad. Pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica represent 2 ends of a disease spectrum of unknown etiology. Herein we describe 2 cases of pityriasis lichenoides et varioliformis acuta, in which human herpesvirus 7 DNA was detected in skin samples by polymerase chain reaction methodology, an association not previously described. This report may support the involvement of viral infection in the etiopathogeny of this disease.

      PubDate: 2017-12-12T06:10:24Z
      DOI: 10.1016/j.ad.2017.03.023
       
  • Histoplasmosis, una micosis endémica emergente
    • Authors: Pulido
      Abstract: Publication date: Available online 6 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): A. Pulido Pérez


      PubDate: 2017-12-12T06:10:24Z
       
  • Granuloma aséptico facial idiopático: hallazgos clínicos y ecográficos
           de 3 casos
    • Authors: A.I. Rodríguez-Bandera; M. Feito-Rodríguez; R. Maseda-Pedrero; R. de Lucas-Laguna
      Abstract: Publication date: Available online 6 December 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): A.I. Rodríguez-Bandera, M. Feito-Rodríguez, R. Maseda-Pedrero, R. de Lucas-Laguna
      El granuloma aséptico facial idiopático es una entidad propia de la infancia que se caracteriza por la presencia de uno o varios nódulos asintomáticos en la mejilla. Aunque su patogenia no está clara, se ha sugerido que pueda pertenecer al espectro de la rosácea infantil. Resuelve espontáneamente pero puede plantear dudas diagnósticas con otras lesiones que sí requieren tratamiento. Presentamos los hallazgos clínicos y ecográficos y la evolución, tanto clínica y ecográfica, de 3 nuevos casos. En 2 pacientes, la lesión se presentó en el contexto de una rosácea infantil. En ecografía, el granuloma aséptico facial idiopático mostró un patrón característico, con variaciones en función del momento evolutivo. La ecografía de alta frecuencia puede facilitar el diagnóstico diferencial, evitando biopsias o extirpaciones innecesarias. Idiopathic facial aseptic granuloma is a typical childhood disease characterized by the presence of one or more asymptomatic nodules on the cheek. Although pathogenesis remains unclear, the disease is thought to be a type of childhood rosacea. It resolves spontaneously, yet it could be confused with other lesions that require treatment. We present clinical and ultrasound findings and outcome from 3 new cases. In 2 cases, the lesion presented as childhood rosacea. Ultrasound revealed a characteristic pattern, with variations depending on the stage of development. High-frequency ultrasound can facilitate the differential diagnosis and thus obviate unnecessary biopsy or excision.

      PubDate: 2017-12-12T06:10:24Z
      DOI: 10.1016/j.ad.2017.08.016
       
 
 
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