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Publisher: Elsevier   (Total: 3030 journals)

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Showing 1 - 200 of 3030 Journals sorted alphabetically
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 20, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 16, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 79, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 22, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 27, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 4)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 5, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 303, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 3)
Acta Biomaterialia     Hybrid Journal   (Followers: 25, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription  
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 196, SJR: 3.683, h-index: 202)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.615, h-index: 21)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 9, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription   (Followers: 1)
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 3, SJR: 0.311, h-index: 16)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 2)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 21, SJR: 1.365, h-index: 73)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 5, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 4)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.383, h-index: 19)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 2)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 5, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 4, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 4)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 5)
Additive Manufacturing     Hybrid Journal   (Followers: 7, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 20)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 120, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 16, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 8, SJR: 0.299, h-index: 15)
Advances in Agronomy     Full-text available via subscription   (Followers: 15, SJR: 2.071, h-index: 82)
Advances in Anesthesia     Full-text available via subscription   (Followers: 24, SJR: 0.169, h-index: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 3)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 6, SJR: 1.054, h-index: 35)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 10, SJR: 0.801, h-index: 26)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 21, SJR: 1.286, h-index: 49)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
Advances in Botanical Research     Full-text available via subscription   (Followers: 3, SJR: 0.619, h-index: 48)
Advances in Cancer Research     Full-text available via subscription   (Followers: 26, SJR: 2.215, h-index: 78)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 0.9, h-index: 30)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 2.139, h-index: 42)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 24, SJR: 0.183, h-index: 23)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 8, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 16, SJR: 0.223, h-index: 22)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 11)
Advances in Digestive Medicine     Open Access   (Followers: 4)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Ecological Research     Full-text available via subscription   (Followers: 39, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 25, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 7)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 38, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 3)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 41, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 14)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 18, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.497, h-index: 31)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 22)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 33, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 3, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 4)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 4)
Advances in Life Course Research     Hybrid Journal   (Followers: 7, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 8)
Advances in Marine Biology     Full-text available via subscription   (Followers: 16, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 5, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 21)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 10)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 6, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 3)
Advances in Oncobiology     Full-text available via subscription   (Followers: 3)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 20, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 14)
Advances in Pharmacology     Full-text available via subscription   (Followers: 13, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 7, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 4)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 17, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 56)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 1, SJR: 0.1, h-index: 2)
Advances in Space Research     Full-text available via subscription   (Followers: 332, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 7)
Advances in Surgery     Full-text available via subscription   (Followers: 6, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 28, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 14)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 12)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 42, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 5, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 304, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 4, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 7, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 390, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 29, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 36, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access  
Agriculture and Natural Resources     Open Access   (Followers: 1)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 48, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 3, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 9, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 5)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access  
Algal Research     Partially Free   (Followers: 7, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 5, SJR: 0.776, h-index: 35)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 6, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 45, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 5)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 3)
American Heart J.     Hybrid Journal   (Followers: 45, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 47, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 34, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 6, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 32, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 25, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 31, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 48, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 174, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 51, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 2)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 22, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 23, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 21, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 32, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 13, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 5)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 52, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 3)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 2, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 38, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 154, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 7, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 10)
Anesthésie & Réanimation     Full-text available via subscription  
Anesthesiology Clinics     Full-text available via subscription   (Followers: 21, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access  
Animal Behaviour     Hybrid Journal   (Followers: 143, SJR: 1.907, h-index: 126)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 5, SJR: 1.151, h-index: 83)
Animal Reproduction Science     Hybrid Journal   (Followers: 5, SJR: 0.711, h-index: 78)
Annales d'Endocrinologie     Full-text available via subscription   (SJR: 0.394, h-index: 30)
Annales d'Urologie     Full-text available via subscription  
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (SJR: 0.177, h-index: 13)
Annales de Chirurgie de la Main et du Membre Supérieur     Full-text available via subscription  
Annales de Chirurgie Plastique Esthétique     Full-text available via subscription   (Followers: 2, SJR: 0.354, h-index: 22)
Annales de Chirurgie Vasculaire     Full-text available via subscription   (Followers: 1)

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Journal Cover Actas Dermo-Sifiliograficas
  [4 followers]  Follow
    
   Full-text available via subscription Subscription journal  (Not entitled to full-text)
   ISSN (Print) 0001-7310
   Published by Elsevier Homepage  [3030 journals]
  • Telangiectasias extensas adquiridas: comparación entre telangiectasia
           esencial generalizada y vasculopatía colágena cutánea
    • Authors: N. Knöpfel; A. Martín-Santiago; C. Saus; M.M. Escudero-Góngora; L.J. del Pozo; C. Gómez
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): N. Knöpfel, A. Martín-Santiago, C. Saus, M.M. Escudero-Góngora, L.J. del Pozo, C. Gómez
      La aparición tardía de telangiectasias cutáneas extensas de forma simétrica y ascendente, sin manifestación sistémica asociada, constituye la forma de presentación típica de la telangiectasia esencial generalizada (TEG). Estudios recientes sugieren que la vasculopatía colágena cutánea (VCC) tiene una presentación clínica idéntica pero los hallazgos histopatológicos son distintivos y permiten diferenciarla de la TEG. Presentamos 2 pacientes con múltiples telangiectasias cutáneas con hallazgos histopatológicos diagnósticos de TEG y de VCC. La dermatoscopia de las telangiectasias en ambos casos fue similar, excepto en las lesiones más antiguas de VCC que presentaba vasos de color violáceo y con una morfología tortuosa en serpentina. Durante el seguimiento de ambas pacientes de 12 y 42 años (TEG y VCC, respectivamente) hemos comprobado que en la TEG las telangiectasias mantienen su aspecto inicial mientras que en la VCC se observó un oscurecimiento progresivo de las lesiones y cambios en la morfología resultando en varicosidades superficiales. The late development of symmetrical, ascending telangiectasias over an extensive area of the skin with no associated systemic manifestations is a common presentation of generalized essential telangiectasia (GET). It was recently suggested that cutaneous collagenous vasculopathy (CCV) is clinically identical to GET but that the 2 conditions can be distinguished by their distinctive histopathologic findings. We present 2 patients, both women, with multiple telangiectasias and describe the histopathologic findings that led to the diagnoses of GET and CCV. Dermoscopic findings in both cases were similar, except that the older telangiectasias in the patient with CCV were violaceous and distributed in a tortuous, serpentine pattern. During follow-up 12 years for the woman with GET and 42 years for the woman with CCV we saw that in GET the lesions remained stable in appearance whereas in CCV there was progressive darkening and morphological changes eventually resulting in superficial varicose veins.
      Graphical abstract image

      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2016.02.020
       
  • Registro de linfomas cutáneos primarios de la AEDV
    • Authors: T. Estrach; O. Servitje; P.L. Ortiz-Romero
      Pages: 181 - 183
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): T. Estrach, O. Servitje, P.L. Ortiz-Romero


      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2017.02.008
       
  • Enfermedad inflamatoria intestinal: abordaje conjunto
           digestivo-dermatológico
    • Authors: M.A. Sánchez-Martínez; E. Garcia-Planella; A. Laiz; L. Puig
      Pages: 184 - 191
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): M.A. Sánchez-Martínez, E. Garcia-Planella, A. Laiz, L. Puig
      La enfermedad inflamatoria intestinal es una entidad compleja que incluye la enfermedad de Crohn y la colitis ulcerosa, y se caracteriza por un estado proinflamatorio crónico con un curso oscilante y que en muchas ocasiones conlleva una gran morbilidad a estos pacientes. En la última década se han identificado distintas dianas terapéuticas que permiten el uso de fármacos biológicos, en particular los anticuerpos dirigidos contra el factor de necrosis tumoral alfa, que se asocian en un 5% de los casos con reacciones paradójicas psoriasiformes, que requieren una estrecha colaboración entre el dermatólogo y el gastroenterólogo en la toma de decisiones. La enfermedad inflamatoria intestinal se asocia, asimismo, a otras diversas manifestaciones dermatológicas y reumatológicas, y presenta una asociación genética y patogénica con la psoriasis, que justifica tanto el abordaje interdisciplinario de estos pacientes como la presente revisión. Inflammatory bowel disease (IBD) is a complex entity that includes Crohn disease and ulcerative colitis. It is characterized by a chronic proinflammatory state of varying intensity that often leads to considerable morbidity. In the last decade, several therapeutic targets have been identified that are susceptible to the use of biological agents, including anti-tumor necrosis factor alpha antibodies, which are associated with paradoxical psoriasiform reactions in 5% of patients. Decision-making in the management of these cases requires close collaboration between the dermatologist and gastroenterologist. Inflammatory bowel disease is also associated with various other dermatologic and rheumatologic manifestations, and presents a genetic and pathogenic association with psoriasis that justifies both the interdisciplinary approach to these patients and the present review.

      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2016.07.007
       
  • Variantes clínico-patológicas de micosis fungoide
    • Authors: H. Muñoz-González; A.M. Molina-Ruiz; L. Requena
      Pages: 192 - 208
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): H. Muñoz-González, A.M. Molina-Ruiz, L. Requena
      La micosis fungoide (MF) es el linfoma primario cutáneo de células T más frecuente. La evolución clínica clásica de la enfermedad se caracteriza por la progresión desde una fase inespecífica de máculas eritematosas a la aparición de placas y, finalmente, tumores en algunos pacientes. Sin embargo, a lo largo de las últimas décadas se han descrito numerosas variantes de MF, tanto desde el punto de vista clínico como histopatológico, con implicaciones terapéuticas y pronósticas específicas. El diagnóstico diferencial se ve dificultado así ante el amplio abanico de manifestaciones clínicas y patrones histopatológicos de infiltración cutánea, especialmente en fases precoces de la enfermedad. Este artículo revisa las principales características clínicas, histopatológicas e inmunohistoquímicas que definen las distintas variantes de MF descritas en la literatura con el objetivo de facilitar el diagnóstico temprano de MF. Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma. The clinical course of the disease is typically characterized by progression from a nonspecific phase of erythematous macules to the appearance of plaques and ultimately, in some patients, tumors. However, numerous clinical and histopathologic variants of MF with specific therapeutic and prognostic implications have been described in recent decades. Clarification of the differential diagnosis can be frustrated by the wide range of clinical manifestations and histopathologic patterns of cutaneous infiltration, particularly in the early phases of the disease. In this paper, we review the main clinical, histopathologic, and immunohistochemical characteristics of the variants of MF described in the literature in order to facilitate early diagnosis of the disease.
      Graphical abstract image

      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2016.08.009
       
  • Estudio descriptivo de costes en melanoma cutáneo de diferentes
           estadios
    • Authors: P. Serra-Arbeloa; Á.O. Rabines-Juárez; M.S. Álvarez-Ruiz; F. Guillén-Grima
      Pages: 229 - 236
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): P. Serra-Arbeloa, Á.O. Rabines-Juárez, M.S. Álvarez-Ruiz, F. Guillén-Grima
      Introducción y objetivo El conocimiento de los recursos utilizados en cada uno de los pasos del diagnóstico y tratamiento de las enfermedades es la base para poder optimizarlos. El melanoma cutáneo es un tipo tumoral en constante incremento, y con un importante coste asociado, por lo que se ha realizado un análisis actualizado de los costes de los procesos de su diagnóstico, terapia y seguimiento en función del estadio de la enfermedad. Métodos Se han elaborado tablas descriptivas de costes directos a partir de un modelo teórico basado en directrices nacionales e internacionales de manejo de pacientes con melanoma cutáneo dependiendo del momento de diagnóstico y evolución. Estas tablas permiten saber el coste de cada paciente individual y de todos aquellos en un mismo estadio. Resultados Los costes para un paciente en el primer año oscilan entre los 1.689 € del estadio I y los 88.268 € del estadio IV, las mayores diferencias se encuentran entre el estadio IA y el IB-IIA y entre el III y IV. Si comparamos los costes de los pacientes en estadio precoz con buena evolución con los de aquellos que recidivaron, las diferencias son considerables: llegan a ser de hasta 50 veces mayores en el primer año y 20 veces mayores en el seguimiento a 10 años. Conclusiones Los elevados costes del diagnóstico del melanoma cutáneo en estadio avanzado evidencian la necesidad de promocionar la prevención primaria y los programas de detección precoz. Nuestros resultados servirán como base para posteriores estudios de coste-efectividad. Background and objective The basis for optimal resource allocation is an understanding of requirements during the diagnostic and treatment phases. Costs associated with the rising incidence of cutaneous melanoma are considerable. We undertook an up-to-date analysis of the cost of diagnosis, treatment, and follow-up according to tumor stage. Methods We constructed descriptive tables following a theoretical model of direct costs based on amounts published in directives for the Spanish national health system and in international guidelines for managing cutaneous melanoma according to stage at diagnosis and clinical course. The tables allowed us to calculate the cost of treating individual patients as well as the expected cost for all patients with tumors in the same stage. Results Individual patients would generate costs ranging from €1689 (for a stage I tumor) to €88, 268 (stage IV). The largest differences were between stages IA and IB–IIA and between stages III and IV. Costs differed greatly between patients with early-stage tumors and favorable outcomes and those with recurring tumors, which cost 50-fold more in the first year and 20-fold more after 10 years of follow-up. Conclusions The high cost of diagnosing advanced-stage cutaneous melanoma calls attention to the need to promote primary prevention and early detection. Our findings provide the knowledge base for cost-effectiveness studies in this disease.
      Graphical abstract
      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2016.09.010
       
  • Objective Structured Clinical Examination as an Assessment Tool for
           Clinical Skills in Dermatology
    • Authors: D. Saceda-Corralo; P. Fonda-Pascual; Ó.M. Moreno-Arrones; A. Alegre-Sánchez; Á. Hermosa-Gelbard; N. Jiménez-Gómez; S. Vañó-Galván; P. Jaén-Olasolo
      Pages: 237 - 243
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): D. Saceda-Corralo, P. Fonda-Pascual, Ó.M. Moreno-Arrones, A. Alegre-Sánchez, Á. Hermosa-Gelbard, N. Jiménez-Gómez, S. Vañó-Galván, P. Jaén-Olasolo
      Background Objective Structured Clinical Evaluation (OSCE) is an excellent method to evaluate student's abilities, but there are no previous reports implementing it in dermatology. Objectives To determine the feasibility of implementation of a dermatology OSCE in the medical school. Methods Five stations with standardized patients and image-based assessment were designed. A specific checklist was elaborated in each station with different items which evaluated one competency and were classified into five groups (medical history, physical examination, technical skills, case management and prevention). Results A total of 28 students were tested. Twenty-five of them (83.3%) passed the exam globally. Concerning each group of items tested: medical interrogation had a mean score of 71.0; physical examination had a mean score of 63.0; management had a mean score of 58.0; and prevention had a mean score of 58.0 points. The highest results were obtained in interpersonal skills items with 91.8 points. Limitations Testing a small sample of voluntary students may hinder generalization of our study. Conclusions OSCE is an useful tool for assessing clinical skills in dermatology and it is possible to carry it out. Our experience enhances that medical school curriculum needs to establish OSCE as an assessment tool in dermatology.
      Graphical abstract image

      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2016.10.016
       
  • The impact of skin diseases on quality of life: A multicenter study
    • Authors: G. Sanclemente; C. Burgos; J. Nova; F. Hernández; C. González; M.I. Reyes; N. Córdoba; Á. Arévalo; E. Meléndez; J. Colmenares; S. Ariza; G. Hernández
      Pages: 244 - 252
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): G. Sanclemente, C. Burgos, J. Nova, F. Hernández, C. González, M.I. Reyes, N. Córdoba, Á. Arévalo, E. Meléndez, J. Colmenares, S. Ariza, G. Hernández
      Introduction To date, no formal study has been published regarding how Colombian patients with skin disorders could be affected according to their perception of disease. Objective To determine the impact in quality of life of skin diseases in a Colombian population. Methods This multicenter study included patients with skin disease from almost the whole country. Individuals >18 years old; of any gender; with any skin disease and who signed informed consent, were included. We applied the Colombian validated version of the Skindex-29 instrument. Results A total of 1896 questionnaires had sufficient information for the analyses. No significant differences in sociodemographic characteristics of patients who returned the questionnaire incomplete vs. complete, were found. Participants mean age was 41.5 years. There were no statistical differences in men vs. women regarding the global (p =0.37), symptoms (p =0.71) and emotions (p =0.32) domains, whereas statistical differences were found in the function domain (p =0.04; Mann–Whitney U test). Psoriasis, contact dermatitis, atopic dermatitis, urticaria, hair disorders, Hansen's disease, scars, hyperhidrosis and genital human papillomavirus disease scored the highest. Limitations Skindex-29 score variability as a result of differences in the location of the skin lesions, their inflammatory or non-inflammatory nature, and the start of therapy. Conclusions Even the most localized or asymptomatic skin lesion in our population leads to a disruption at some level of patient's wellness. This study adds well supported scientific data of the burden of skin diseases worldwide.
      Graphical abstract image

      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2016.11.008
       
  • Tumoración subcutánea en la cola de la ceja derecha
    • Authors: P.P. García-Montero; A. Hernández-Nuñez; J.C. Tardío
      Pages: 253 - 254
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): P.P. García-Montero, A. Hernández-Nuñez, J.C. Tardío


      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2015.10.022
       
  • Placas infiltradas de rápida evolución en paciente trasplantado
    • Authors: I. Salgüero Fernández; F. ALfageme Roldán; D. Suarez Massa; G. Roustan Gullón
      Pages: 255 - 256
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): I. Salgüero Fernández, F. ALfageme Roldán, D. Suarez Massa, G. Roustan Gullón


      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2016.05.007
       
  • Placa indurada con ulceración y necrosis en tórax
    • Authors: M.A. Flores-Terry; G. Romero-Aguilera; M. García-Arpa
      First page: 259
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): M.A. Flores-Terry, G. Romero-Aguilera, M. García-Arpa


      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2016.02.016
       
  • Penfigoide ampolloso localizado en la aréola mamaria
    • Authors: P. López Jiménez; Á. Vargas Nevado; E. Herrera Ceballos
      First page: 260
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): P. López Jiménez, Á. Vargas Nevado, E. Herrera Ceballos


      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2015.12.014
       
  • Baños de parafina para el tratamiento del eccema crónico de las
           manos
    • Authors: J.F. Mir-Bonafé; E. Serra-Baldrich; E. Rozas-Muñoz; L. Puig
      Pages: 261 - 264
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): J.F. Mir-Bonafé, E. Serra-Baldrich, E. Rozas-Muñoz, L. Puig


      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2016.09.019
       
  • Tricomicosis axilar: diagnóstico en imágenes, clínica, luz
           de Wood y dermatoscopia
    • Authors: E. Rojas Mora; A. Freites Martínez; A. Hernández-Núñez; J. Borbujo Martínez
      Pages: 264 - 266
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): E. Rojas Mora, A. Freites Martínez, A. Hernández-Núñez, J. Borbujo Martínez


      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2016.09.018
       
  • Sarcoma de Kaposi de tipo linfangiomatoso
    • Authors: F. Martínez-Ortiz; M.P. Gómez Avivar
      Pages: 268 - 271
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): F. Martínez-Ortiz, M.P. Gómez Avivar


      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2016.09.016
       
  • Mucinosis nodular asociada a gammapatía monoclonal de cadenas ligeras
           de significado incierto
    • Authors: P. Rodríguez-Jiménez; P. Chicharro; A. Ascensión; D. de Argila; E. Daudén
      Pages: 272 - 273
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): P. Rodríguez-Jiménez, P. Chicharro, A. Ascensión, D. de Argila, E. Daudén


      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2016.09.015
       
  • Valoración inicial del paciente adulto con condilomas acuminados
    • Authors: A. Imbernón-Moya; J. Ballesteros
      Pages: 273 - 275
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): A. Imbernón-Moya, J. Ballesteros


      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2016.09.013
       
  • Pénfigo herpetiforme: revisión de un caso en edad
           pediátrica
    • Authors: V.L. Taliercio; B. Ferrari; M.E. Abad; M. Larralde
      Pages: 276 - 277
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): V.L. Taliercio, B. Ferrari, M.E. Abad, M. Larralde


      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2016.07.023
       
  • Progressive limitation of mouth opening
    • Authors: P. García-Martínez; S. Segura; J.E. Herrero-Gonzalez; R.M. Pujol
      Pages: 278 - 279
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): P. García-Martínez, S. Segura, J.E. Herrero-Gonzalez, R.M. Pujol


      PubDate: 2017-03-25T05:31:26Z
      DOI: 10.1016/j.ad.2016.07.020
       
  • Respuesta a omalizumab en 3 casos de urticaria solar
    • Authors: P. Rodríguez-Jiménez; P. Chicharro; A. Pérez-Plaza; D. de Argila
      Abstract: Publication date: Available online 27 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): P. Rodríguez-Jiménez, P. Chicharro, A. Pérez-Plaza, D. de Argila
      Se presentan 3 pacientes con urticaria solar que o no habían respondido adecuadamente o presentaban limitaciones a los tratamientos de primera línea (antihistamínicos H1 a dosis altas o fototerapia), que fueron tratados con omalizumab. Dos de ellos mejoraron clínicamente con un aumento muy importante de la tolerancia a la luz, uno de ellos con clara mejoría de la calidad de vida. El otro paciente no mejoró y desarrolló una reacción local leve a la medicación inyectada. Omalizumab puede ser por tanto una alternativa terapéutica potencialmente útil y segura en urticarias solares graves no respondedoras al tratamiento convencional. We report 3 cases of solar urticaria in which there was no response or limited response to first-line treatments with high-dose H1 antihistamines or phototherapy. The patients were then treated with omalizumab. Symptoms improved in 2 patients, whose tolerance to sunlight increased considerably; quality of life clearly improved for 1 of these patients. The third experienced no improvement and developed a mild local reaction to the injected medication. We conclude that omalizumab may offer a potentially safe, useful alternative for patients with solar urticaria who do not respond to conventional therapy.

      PubDate: 2017-04-28T08:48:16Z
      DOI: 10.1016/j.ad.2016.08.011
       
  • Impacto del vitíligo en la calidad de vida
    • Authors: M.A. Morales-Sánchez; M. Vargas-Salinas; M.L. Peralta-Pedrero; M.G. Olguín-García; F. Jurado-Santa Cruz
      Abstract: Publication date: Available online 26 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M.A. Morales-Sánchez, M. Vargas-Salinas, M.L. Peralta-Pedrero, M.G. Olguín-García, F. Jurado-Santa Cruz
      Introducción y objetivo El vitíligo es una dermatosis autoinmune crónica causada por la destrucción de los melanocitos. Aunque la calidad de vida en pacientes con vitíligo se ha estudiado en diferentes poblaciones, hasta el momento no existen estudios previos sobre el tema en nuestra población. El objetivo de este estudio era determinar la calidad de vida de pacientes con vitíligo mexicanos. Material y método Se realizó un estudio transversal en la Unidad de Investigación del Centro Dermatológico Dr. Ladislao de la Pascua en la ciudad de México. Se reclutaron adultos con vitíligo, se excluyeron los individuos con otras alteraciones de la pigmentación, diagnóstico de enfermedad neurológica y/o psiquiátrica y en tratamiento farmacológico con sustancias que afectaran su estado mental. Todos los pacientes contestaron los cuestionarios DLQI y VitiQoL y los inventarios de depresión y ansiedad de Beck. Resultados Se reclutaron 150 pacientes con vitíligo, 68,7% (103) mujeres y 31,3% (47) hombres. La mediana de edad fue de 38 años±20 años. En nuestros pacientes el promedio de la puntuación del DLQI fue de 5,2±5,4 y el del VitiQoL fue de 32,1 (DE: 22,7), de los 30 y 90 puntos posibles de cada instrumento, respectivamente. La correlación de los resultados de ambos cuestionarios fue de 0,675, p<0,001. Los pacientes con afectación de genitales reportaron una puntuación mayor en el cuestionario de calidad de vida VitiQoL que aquellos sin afectación de esa zona corporal, 43,5 (DE: 28,4) vs. 28,98 (DE: 20,08), p<0,001. La prevalencia de depresión y ansiedad fue del 34% y 60%, respectivamente. Conclusión El impacto del vitíligo en la calidad de vida de nuestra muestra de pacientes fue mínimo. El vitíligo en los genitales se asocia a un deterioro de la calidad de vida. Introduction and objective Vitiligo is a chronic autoimmune skin disease caused by the destruction of melanocytes. Although quality of life (QOL) in vitiligo has been studied in different countries, it has not yet been investigated in Mexico. The aim of this study was to assess the QOL of Mexican patients with vitiligo. Material and method We conducted a cross-sectional study at the research unit of Centro Dermatológico Dr. Ladislao de la Pascua in Mexico City. We included adults with vitiligo and excluded those with other pigmentation disorders or a neurological or psychiatric disorder. Patients on psychoactive medications were also excluded. All the patients were administered the Dermatology Life Quality Index (DLQI), a vitiligo-specific quality of life instrument (the VitiQoL), and the Beck Depression and Anxiety Inventories. Results We studied 150 patients with vitiligo (103 women [68.7%] and 47 men [31.3%]). The median (interquartile range) age was 38 (20) years. The mean (SD) scores on the DLQI and VitiQoL were 5.2 (5.4) and 32.1 (22.7) out of total possible scores of 30 and 90, respectively. The correlation between questionnaire scores was 0.675 (P <.001). Patients with genital involvement scored significantly worse on the VitiQoL than those without lesions in this area (43.95 [28.4]) vs. 28.98 [20.08], P <.001). The prevalence of depression and anxiety was 34% and 60%, respectively.
      PubDate: 2017-04-28T08:48:16Z
      DOI: 10.1016/j.ad.2017.03.007
       
  • Enfermedades autoinflamatorias en dermatología pediátrica. Parte 1:
           síndromes urticariformes, síndromes pustulosos y síndromes con
           ulceraciones cutáneo-mucosas
    • Authors: S. Hernández-Ostiz; L. Prieto-Torres; G. Xirotagaros; L. Noguera-Morel; Á. Hernández-Martín; A. Torrelo
      Abstract: Publication date: Available online 23 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): S. Hernández-Ostiz, L. Prieto-Torres, G. Xirotagaros, L. Noguera-Morel, Á. Hernández-Martín, A. Torrelo
      Las enfermedades monogénicas autoinflamatorias son un grupo de enfermedades emergentes y heterogéneas en continuo estudio y desarrollo en la actualidad. Nuestro objetivo es revisar estas enfermedades desde el punto de vista de su etiopatogenia y principales manifestaciones, con el fin de proponer una clasificación, basada en las características clinicopatológicas de las lesiones cutáneas típicas, que resulte de utilidad en la práctica clínica habitual de los dermatólogos. El texto está enfocado en el diagnóstico de estos síndromes durante la edad pediátrica, ya que es el periodo habitual de aparición de los primeros síntomas y signos. La primera parte de la revisión se centrará en el desarrollo de los síndromes urticariformes, que incluyen a su vez las criopirinopatías y los síndromes hereditarios asociados a fiebres periódicas, y de los síndromes pustulosos, resumiendo al final del texto las alternativas terapéuticas de estos síndromes autoinflamatorios y sus mutaciones genéticas. Monogenic autoinflammatory diseases are a heterogeneous emergent group of conditions that are currently under intensive study. We review the etiopathogenesis of these syndromes and their principal manifestations. Our aim is to propose a classification system based on the clinicopathologic features of typical skin lesions for routine clinical use in dermatology. Our focus is on diagnosis in pediatric practice given that this is the period when the signs and symptoms of these syndromes first appear. In Part 1 we discuss the course of urticaria-like syndromes, which include cryopyrin-associated periodic conditions and hereditary periodic fever syndromes. Pustular syndromes are also covered in this part. Finally, we review the range of therapies available as well as the genetic mutations associated with these autoinflammatory diseases.
      Graphical abstract image

      PubDate: 2017-04-28T08:48:16Z
      DOI: 10.1016/j.ad.2016.12.021
       
  • Trasplante de folículos pilosos en úlceras crónicas: un
           nuevo concepto de injerto
    • Authors: M.L. Martínez Martínez; E. Escario Travesedo; F. Jiménez Acosta
      Abstract: Publication date: Available online 21 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M.L. Martínez Martínez, E. Escario Travesedo, F. Jiménez Acosta
      Las úlceras venosas crónicas de los miembros inferiores representan un reto terapéutico importante en la práctica clínica diaria, resultando primordial la búsqueda de nuevas alternativas que mejoren la curación de estas heridas. Pese al tratamiento habitual con compresión, desbridamiento y uso de apósitos, muchas úlceras permanecen sin cicatrizar. En estas úlceras que no curan uno de los tratamientos más empleados es el trasplante de injertos cutáneos en sus diversas variantes: pinch grafts, punch grafts, injertos de piel de espesor parcial, injertos de piel de grosor total e injertos elaborados a partir de células cultivadas en laboratorio. En los últimos años numerosos estudios han destacado el importante papel del folículo piloso en el proceso de cicatrización de las heridas cutáneas. Trasladando a la práctica estos conocimientos se han utilizado folículos pilosos del cuero cabelludo en injertos tipo punch que son trasplantados al lecho de las úlceras crónicas para estimular su curación. Los resultados parecen ser mejores que el trasplante tradicional de injertos tipo punch sin pelo, lo cual proporciona nuevas líneas de tratamiento para las úlceras venosas crónicas recalcitrantes. Chronic venous leg ulcers are a major therapeutic challenge in clinical practice, and the search for new approaches to improve wound healing is essential. Many ulcers do not heal with traditional treatment using compression, debridement, and dressings. Skin-grafts variants, such as pinch grafts, punch grafts, split- or full-thickness skin grafts, and grafts derived from cells cultured in the laboratory, are among the most widely used options in ulcers that do not heal. In recent years, numerous studies have brought to our attention the important role of the hair follicle in the healing process of cutaneous wounds. Putting knowledge into practice, hair follicles from the scalp have been used in punch-type grafts transplanted to the base of chronic ulcers to stimulate healing. Results appear to be better than those with traditional hairless punch grafts, opening new lines of treatment for recalcitrant chronic venous ulcers.
      Graphical abstract image

      PubDate: 2017-04-28T08:48:16Z
      DOI: 10.1016/j.ad.2017.02.013
       
  • Angiosarcoma cutáneo: la importancia de la sospecha clínica
    • Authors: Toll
      Abstract: Publication date: Available online 21 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): A. Toll


      PubDate: 2017-04-28T08:48:16Z
       
  • Vasculitis con lesiones en cuero cabelludo como única
           manifestación cutánea
    • Authors: F.C. Benavente Villegas; J.M. Sánchez Motilla; N. Rausell Fontestad
      Abstract: Publication date: Available online 21 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): F.C. Benavente Villegas, J.M. Sánchez Motilla, N. Rausell Fontestad


      PubDate: 2017-04-28T08:48:16Z
      DOI: 10.1016/j.ad.2016.08.010
       
  • Enfermedades autoinflamatorias en dermatología pediátrica. Parte 2:
           síndromes histiocítico-macrofágicos y síndromes vasculopáticos
    • Authors: S. Hernández-Ostiz; G. Xirotagaros; L. Prieto-Torres; L. Noguera-Morel; A. Torrelo
      Abstract: Publication date: Available online 21 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): S. Hernández-Ostiz, G. Xirotagaros, L. Prieto-Torres, L. Noguera-Morel, A. Torrelo
      El descubrimiento de nuevos síndromes autoinflamatorios y nuevas mutaciones está avanzando a una velocidad vertiginosa en los últimos años. La segunda parte de la revisión está centrada en el estudio de los síndromes histiocítico-macrofágicos y de los síndromes vasculopáticos, incluyendo al final del texto una tabla con las alternativas terapéuticas de estos síndromes autoinflamatorios y sus mutaciones genéticas. The discovery of new autoinflammatory syndromes and novel mutations has advanced at breakneck speed in recent years. Part 2 of this review focuses on vasculitis syndromes and the group of histiocytic and macrophage activation syndromes. We also include a table showing the mutations associated with these autoinflammatory syndromes and treatment alternatives.
      Graphical abstract image

      PubDate: 2017-04-28T08:48:16Z
      DOI: 10.1016/j.ad.2016.12.022
       
  • Nuevos avances de tratamiento inmunobiológico en el melanoma avanzado
    • Authors: M.C. Pérez Gago; O. Saavedra Santa Gadea; L. de la Cruz-Merino
      Abstract: Publication date: Available online 4 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M.C. Pérez Gago, O. Saavedra Santa Gadea, L. de la Cruz-Merino
      El melanoma irresecable localmente avanzado y metastásico es una situación clínica asociada a una elevada tasa de morbimortalidad. En los últimos años, sin embargo, han acontecido notables avances en el ámbito del tratamiento sistémico de esta enfermedad, con la irrupción de la terapia dirigida con inhibidores tirosincinasa que actúan bloqueando la vía de las MAPKinasas, y de la moderna inmunoterapia con anticuerpos monoclonales inmunomoduladores. En la presente revisión se realiza una actualización sobre los datos disponibles con los nuevos inmunoterápicos, así como un repaso del desarrollo clínico que ha permitido la aprobación para su uso en la práctica clínica habitual. Metastatic or locally advanced unresectable melanoma carries a high morbidity and mortality. However, notable advances have been made in recent years in the systemic treatment of this disease, with the appearance of targeted therapy using tyrosine kinase inhibitors that block the mitogen activated protein kinase pathway, and of modern immunotherapy with immune-modulating monoclonal antibodies. In this paper, we provide an update of available data on new immune therapies and we review the clinical development that led to their approval for use in routine clinical practice.

      PubDate: 2017-04-28T08:48:16Z
      DOI: 10.1016/j.ad.2017.01.016
       
  • Un tumor rosado, hiperplasia angiolinfoide con eosinofilia
    • Authors: I. Pérez-López; A. Martínez-López; P. Aguayo-Carreras; M.J. Naranjo-Díaz
      Abstract: Publication date: Available online 20 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): I. Pérez-López, A. Martínez-López, P. Aguayo-Carreras, M.J. Naranjo-Díaz


      PubDate: 2017-04-21T08:19:51Z
      DOI: 10.1016/j.ad.2016.10.022
       
  • Terapias no quirúrgicas para el carcinoma basocelular: revisión
    • Authors: S. Ariza; S. Espinosa; M. Naranjo
      Abstract: Publication date: Available online 19 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): S. Ariza, S. Espinosa, M. Naranjo
      El carcinoma basocelular (CBC) es el tumor maligno más frecuente en seres humanos, y tiene la capacidad de causar una significativa morbilidad asociada a su potencial de destrucción local. El tratamiento del CBC demanda altos costes de atención para los sistemas de salud, por la gran incidencia de esta enfermedad, especialmente en pacientes mayores. El tratamiento estándar para la mayoría de los CBC consiste en la resección quirúrgica con márgenes y control histológico de los bordes de sección, o mediante cirugía micrográfica de Mohs. Sin embargo, en algunos pacientes con contraindicación para cirugía, que tienen comorbilidades importantes o altas expectativas estéticas, existen en la actualidad nuevas alternativas terapéuticas no quirúrgicas, con las cuales se puede lograr muy buen control local, preservar la función y obtener un excelente resultado cosmético. Basal cell carcinoma (BCC) is the most prevalent malignant tumor in humans and the local destruction of tissue that can result from excision has a significant impact on well-being. Treating BCC is costly for health care systems given the high incidence of this tumor, especially in older patients. Standard treatment involves either resection with histologic assessment of margins or Mohs micrographic surgery. Surgery is sometimes contraindicated, however, due to the presence of significant comorbidity or high cosmetic expectations. For such patients, nonsurgical treatments have become available. These alternatives can offer good local control of disease, preserve function, and achieve excellent cosmetic results.
      Graphical abstract image

      PubDate: 2017-04-21T08:19:51Z
      DOI: 10.1016/j.ad.2017.01.018
       
  • Consideraciones sobre los análisis de subgrupos en los ensayos
           clínicos
    • Authors: P. Coto-Segura
      Abstract: Publication date: Available online 18 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): P. Coto-Segura


      PubDate: 2017-04-21T08:19:51Z
      DOI: 10.1016/j.ad.2017.03.003
       
  • Lesión eritematosa nasal
    • Authors: D. González Fernández; S. Requena López; F. Valdés Pineda
      Abstract: Publication date: Available online 14 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): D. González Fernández, S. Requena López, F. Valdés Pineda


      PubDate: 2017-04-21T08:19:51Z
      DOI: 10.1016/j.ad.2016.07.029
       
  • Terapia fotodinámica con azul de metileno en úlceras cutáneas
           infectadas con participación de Pseudomonas aeruginosa y Fusarium spp.:
           una alternativa a considerar
    • Authors: Aspiroz Sevil; Toyas Gilaberte
      Abstract: Publication date: Available online 13 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): C. Aspiroz, M. Sevil, C. Toyas, Y. Gilaberte
      La terapia fotodinámica es una modalidad terapéutica que tiene una importante acción antimicrobiana. Se presentan 2 casos clínicos de úlceras crónicas en las extremidades inferiores sobreinfectadas por hongos y bacterias de difícil manejo, en los que el tratamiento fotodinámico con azul de metileno como fotosensibilizante resultó en la curación clínica y microbiológica. No se presentaron efectos adversos reseñables. La posibilidad de utilizar la terapia fotodinámica con azul de metileno en el manejo de las úlceras crónicas sobreinfectadas constituye una interesante alternativa para reducir el uso de antibióticos y disminuir la aparición de resistencias. Photodynamic therapy (PDT) is a therapeutic modality with significant antimicrobial activity. We present 2 cases of chronic lower limb ulcers in which fungal and bacterial superinfection complicated management. PDT with methylene blue as the photosensitizer led to clinical and microbiological cure with no significant adverse effects. PDT with methylene blue is a valid option for the management of superinfected chronic ulcers, reducing the use of antibiotics and the induction of resistance.
      Graphical abstract image

      PubDate: 2017-04-13T17:45:13Z
       
  • Expanding the Genotype of Sjögren–Larsson Syndrome: A New Case
           Due to Two Novel Mutations
    • Authors: E. García-Peris; I. Latour-Álvarez; M. Pestana-Eliche; R. Sánchez
      Abstract: Publication date: Available online 11 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): E. García-Peris, I. Latour-Álvarez, M. Pestana-Eliche, R. Sánchez


      PubDate: 2017-04-13T17:45:13Z
      DOI: 10.1016/j.ad.2016.12.015
       
  • Enfermedad de Darier acral hemorrágica
    • Authors: M.Á. Flores-Terry; M. García-Arpa; M. Llamas-Velasco; C. Mendoza-Chaparro; C. Ramos-Rodríguez
      Abstract: Publication date: Available online 10 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M.Á. Flores-Terry, M. García-Arpa, M. Llamas-Velasco, C. Mendoza-Chaparro, C. Ramos-Rodríguez
      La enfermedad de Darier es una genodermatosis autosómica dominante, que se produce por la mutación de un gen, que produce una proteína que interviene en la regulación de los canales de calcio; presenta distintas manifestaciones clínicas y falta de consistencia genotipo/fenotipo. La variante acral hemorrágica se caracteriza por máculas, pápulas, vesículas y/o ampollas hemorrágicas en zonas acrales, puede asociar otras manifestaciones clásicas de la enfermedad de Darier en el mismo paciente o sus familiares; en la histopatología se evidencia disqueratosis y acantólisis suprabasal con formación de lagunas hemorrágicas. Reportamos 3 nuevos casos de esta variante desencadenados por traumatismo y evidenciando buena respuesta con retinoides. Darier disease is an autosomal-dominant inherited condition caused by mutation of a gene, which produces a protein involved in calcium channel regulation. The disease has a variety of manifestations and lacks consistent genotype–phenotype correlations. Acral hemorrhagic Darier disease causes macules, papules, vesicles and/or hemorrhagic blisters on the extremities. Other classic signs of the disease may be present in the same patient or relatives. Histopathology reveals dyskeratosis and suprabasal acantholysis with hemorrhagic lacunae. We report 3 new cases of this type of Darier disease triggered by injuries. Response to retinoid therapy was good.
      Graphical abstract image

      PubDate: 2017-04-13T17:45:13Z
      DOI: 10.1016/j.ad.2017.02.012
       
  • Dermatomiositis edematosa asociada a probable síndrome de Evans
    • Authors: M.Á. Flores-Terry; M. García-Arpa; J. Anino-Fernández; M.D. Mínguez-Sánchez
      Abstract: Publication date: Available online 10 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M.Á. Flores-Terry, M. García-Arpa, J. Anino-Fernández, M.D. Mínguez-Sánchez


      PubDate: 2017-04-13T17:45:13Z
      DOI: 10.1016/j.ad.2017.01.020
       
  • Estudio multicéntrico sobre el uso de oxibutinina oral en
           hiperhidrosis local y multifocal
    • Authors: T. Toledo-Pastrana; J. Márquez-Enríquez; J.F. Millán-Cayetano
      Abstract: Publication date: Available online 5 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): T. Toledo-Pastrana, J. Márquez-Enríquez, J.F. Millán-Cayetano


      PubDate: 2017-04-07T05:40:56Z
      DOI: 10.1016/j.ad.2016.11.013
       
  • Acropigmentación reticulada de Kitamura y nevus de Ito
    • Authors: M. García-Arpa; M. Franco-Muñoz; M.A. Flores-Terry; C. Ramos-Rodríguez
      Abstract: Publication date: Available online 5 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M. García-Arpa, M. Franco-Muñoz, M.A. Flores-Terry, C. Ramos-Rodríguez


      PubDate: 2017-04-07T05:40:56Z
      DOI: 10.1016/j.ad.2016.11.024
       
  • Melanomas sobre tatuajes: una asociación casual con implicaciones
           prácticas
    • Authors: M. Armengot-Carbó; N. Barrado-Solís; C. Martínez-Lahuerta; E. Gimeno-Carpio
      Abstract: Publication date: Available online 5 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M. Armengot-Carbó, N. Barrado-Solís, C. Martínez-Lahuerta, E. Gimeno-Carpio


      PubDate: 2017-04-07T05:40:56Z
      DOI: 10.1016/j.ad.2016.11.023
       
  • Fiabilidad de una aplicación de ayuda a la toma de decisiones
           terapéuticas en el paciente con psoriasis (MDi Psoriasis®)
    • Authors: D. Moreno-Ramírez; J.M. Herrerías-Esteban; T. Ojeda-Vila; J.M. Carrascosa; G. Carretero; P. de la Cueva; C. Ferrándiz; M. Galán; R. Rivera; L. Rodríguez-Fernández; R. Ruiz-Villaverde; L. Ferrándiz
      Abstract: Publication date: Available online 4 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): D. Moreno-Ramírez, J.M. Herrerías-Esteban, T. Ojeda-Vila, J.M. Carrascosa, G. Carretero, P. de la Cueva, C. Ferrándiz, M. Galán, R. Rivera, L. Rodríguez-Fernández, R. Ruiz-Villaverde, L. Ferrándiz
      Introducción Las decisiones terapéuticas en el paciente con psoriasis están influidas por factores de la enfermedad (gravedad, localización, etc.), de las comorbilidades y de otras circunstancias demográficas y clínicas asociadas. Objetivo Evaluar la fiabilidad de una aplicación móvil, MDi-Psoriasis®, como instrumento de ayuda al dermatólogo en la toma de decisiones terapéuticas en pacientes con psoriasis moderada-grave. Método Estudio de concordancia interobservador entre las recomendaciones terapéuticas emitidas por un grupo de expertos y MDi-Psoriasis® sobre 10 casos clínicos complejos de psoriasis moderada-grave. Para cada uno de los casos los expertos fueron preguntados por el tratamiento más adecuado, posible y no adecuado. Los mismos 10 casos clínicos fueron sometidos a la aplicación MDi-Psoriasis® y se calcularon las concordancias interobservador pareada (kappa de Cohen) y múltiple (kappa de Fleiss), y el porcentaje de acuerdo entre las recomendaciones. Resultados Sobre un total de 1.210 observaciones el porcentaje promedio de acuerdo fue del 51,3% (IC 95%: 48,5-54,1%), con una concordancia pareada de kappa=0,29 y múltiple de kappa=0,28. El acuerdo promedio entre pares de observadores, sin MDi-Psoriasis®, fue del 50,5% (IC 95%: 47,6-53,5%). La concordancia pareada entre las recomendaciones emitidas por MDi-Psoriasis® y la opinión mayoritaria de los expertos fue de kappa=0,44, con un acuerdo del 68,2%. Conclusiones MDi-Psoriasis® puede emitir recomendaciones comparables a las emitidas por un experto en psoriasis. Introduction Therapeutic decisions in psoriasis are influenced by disease factors (e.g., severity or location), comorbidity, and demographic and clinical features. Objective We aimed to assess the reliability of a mobile telephone application (MDi-Psoriasis) designed to help the dermatologist make decisions on how to treat patients with moderate to severe psoriasis. Method We analyzed interobserver agreement between the advice given by an expert panel and the recommendations of the MDi-Psoriasis application in 10 complex cases of moderate to severe psoriasis. The experts were asked their opinion on which treatments were most appropriate, possible, or inappropriate. Data from the same 10 cases were entered into the MDi-Psoriasis application. Agreement was analyzed in 3 ways: paired interobserver concordance (Cohen's κ), multiple interobserver concordance (Fleiss's κ), and percent agreement between recommendations. Results The mean percent agreement between the total of 1210 observations was 51.3% (95% CI, 48.5–54.1%). Cohen's κ statistic was 0.29 and Fleiss's κ wa...
      PubDate: 2017-04-07T05:40:56Z
      DOI: 10.1016/j.ad.2017.02.009
       
  • Ecografía del síndrome linfoproliferativo primario cutáneo T CD4+ de
           célula pequeña/mediana
    • Authors: E. Rodríguez-Lomba; I. Molina-López; A. Pulido-Pérez; C. Ciudad-Blanco
      Abstract: Publication date: Available online 4 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): E. Rodríguez-Lomba, I. Molina-López, A. Pulido-Pérez, C. Ciudad-Blanco


      PubDate: 2017-04-07T05:40:56Z
      DOI: 10.1016/j.ad.2016.11.022
       
  • Cavernomatosis cerebral múltiple: cuando la clave del
           diagnóstico está en la piel
    • Authors: M.M. Escudero-Góngora; A. Bauzá; A. Giacaman; A. Martín-Santiago
      Abstract: Publication date: Available online 4 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M.M. Escudero-Góngora, A. Bauzá, A. Giacaman, A. Martín-Santiago


      PubDate: 2017-04-07T05:40:56Z
      DOI: 10.1016/j.ad.2016.12.019
       
  • Método simple y efectivo para el tratamiento de los cilindromas en el
           síndrome de Brooke-Spiegler
    • Authors: S. Lucas-Truyols; C. Lloret-Ruiz; F. Millán-Parrilla; E. Gimeno-Carpio
      Abstract: Publication date: Available online 4 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): S. Lucas-Truyols, C. Lloret-Ruiz, F. Millán-Parrilla, E. Gimeno-Carpio


      PubDate: 2017-04-07T05:40:56Z
      DOI: 10.1016/j.ad.2016.11.011
       
  • Treatment of Human Scabies with Oral Ivermectin. Eczematous Eruptions as a
           New Non-Reported Adverse Event
    • Authors: J. Sanz-Navarro; C. Feal; E. Dauden
      Abstract: Publication date: Available online 3 April 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): J. Sanz-Navarro, C. Feal, E. Dauden
      Background Oral ivermectin is an alternative therapy for human scabies infection due to its ease of administration and good safety profile. However, there is no definitive consensus on the optimal dosing regimen. Objective To describe the treatment of human scabies with different dosages of oral ivermectin and the possible adverse events. Methods 23 patients with human scabies were treated with oral ivermectin: 10 patients received a single oral dose of 200μg/kg and 13 a dose of 400μg/kg. A second, or even a third dose, was administered in cases of treatment failure. Results A complete clinical response was achieved by all of the patients. The first ten patients required at least two (80%) or three (20%) doses of ivermectin for complete resolution of the infection. The remaining cases resolved with a single 400μg/kg oral dose. Within the first 72h after the administration of oral ivermectin, new cutaneous lesions were observed in eleven patients (47.8%). Cutaneous biopsies showed signs of subacute eczema. The eruption was treated with topical corticosteroids and emollient therapy. There was no other new drug administration or a history of irritants. There was no history of atopic diathesis except for one patient. Conclusions Oral ivermectin is an effective therapy for the treatment of human scabies. A single 400μg/kg oral dose demonstrated high efficacy and good tolerance. However, the appearance of eczematous cutaneous lesions induced by oral ivermectin has not previously been reported in the literature. Dermatologists should be aware of this possible adverse event.
      Graphical abstract image

      PubDate: 2017-04-07T05:40:56Z
      DOI: 10.1016/j.ad.2017.02.011
       
  • Panarteritis nudosa con patrón de respuesta inflamatoria
           sistémica: respuesta a anti-TNF
    • Authors: F. Tous-Romero; E. Rodríguez-Almaraz; J.L. Rodríguez-Peralto; C. Postigo-Llorente
      Abstract: Publication date: Available online 31 March 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): F. Tous-Romero, E. Rodríguez-Almaraz, J.L. Rodríguez-Peralto, C. Postigo-Llorente


      PubDate: 2017-04-07T05:40:56Z
      DOI: 10.1016/j.ad.2017.01.021
       
  • Imagen ecográfica de xantogranuloma juvenil
    • Authors: C. Martínez-Morán; B. Echeverría-García; J.C. Tardío; J. Borbujo
      Abstract: Publication date: Available online 31 March 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): C. Martínez-Morán, B. Echeverría-García, J.C. Tardío, J. Borbujo


      PubDate: 2017-04-07T05:40:56Z
      DOI: 10.1016/j.ad.2016.11.021
       
  • Exéresis en U para onicocriptosis
    • Abstract: Publication date: Available online 31 March 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): M. Sánchez-Regaña


      PubDate: 2017-03-31T05:36:47Z
       
  • No aparecen más síntomas obsesivo-compulsivos en madres de hijos con
           dermatitis atópica
    • Authors: J. Olivera Pueyo
      Abstract: Publication date: Available online 31 March 2017
      Source:Actas Dermo-Sifiliográficas
      Author(s): J. Olivera Pueyo


      PubDate: 2017-03-31T05:36:47Z
      DOI: 10.1016/j.ad.2017.02.007
       
  • Dermatosis inflamatorias asociadas a radioterapia
    • Authors: Pulido
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): I. Hernández Aragüés, A. Pulido Pérez, R. Suárez Fernández
      La radioterapia es una técnica de uso creciente en el campo de la oncología. Debido al alto recambio celular cutáneo, la radiación ionizante afecta colateralmente a la piel y encontramos de forma frecuente dermatosis inflamatorias asociadas a radioterapia. Algunos de estos cuadros, como la radiodermitis o el fenómeno de recall, son bien conocidos por el dermatólogo. Es importante reconocer otros cuadros cutáneos asociados a radioterapia que aparecen de forma menos frecuente y que en muchas ocasiones son infradiagnosticados. Radiotherapy for cancer is used increasingly. Because skin cells undergo rapid turnover, the ionizing radiation of radiotherapy has collateral effects that are often expressed in inflammatory reactions. Some of these reactions–radiodermatitis and recall phenomenon, for example–are very familiar to dermatologists. Other, less common radiotherapy-associated skin conditions are often underdiagnosed but must also be recognized.
      Graphical abstract image

      PubDate: 2017-03-25T05:31:26Z
       
  • Novedades terapéuticas en tricología
    • Authors: Camacho
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): S. Vañó-Galván, F. Camacho
      La tricología ocupa un área importante dentro de la práctica asistencial de los dermatólogos por la frecuencia de las diferentes tricosis y por el gran impacto que producen en la calidad de vida de los pacientes. Durante los últimos años hemos comprobado la incorporación de muchas novedades terapéuticas en tricología. El objetivo de la presente revisión es resumir de una forma práctica las principales novedades terapéuticas tricológicas, agrupándolas en 4 apartados: a) alopecia androgénica: nuevos excipientes de minoxidil, dutasterida y finasterida oral y nuevas formas de aplicación de estos antiandrógenos, agonistas y antagonistas de las prostaglandinas, láser de baja potencia y medicina regenerativa —activadores de la vía Wnt y terapia con células madre—; b) alopecia areata: fármacos anti-JAK; c) alopecia frontal fibrosante: antiandrógenos y, en algunos pacientes, pioglitazonas, y d) trasplante capilar: nuevos dispositivos tecnológicos y nuevas técnicas de extracción para optimizar la reserva de unidades foliculares. The treatment of hair loss is an important part of clinical dermatology given the prevalence of the problem and great impact on patients’ quality of life. Many new treatments have been introduced in recent years. This review summarizes the main ones in 4 groups: a) For androgenetic alopecia, we discuss new excipients for oral minoxidil, dutasteride, and finasteride as well as new forms of topical application; prostaglandin agonists and antagonists; low-level laser therapy; and regenerative medicine with Wnt signaling activators and stem cell therapy. b) For alopecia areata, Janus kinase inhibitors are reviewed. c) For frontal fibrosing alopecia, we discuss the use of antiandrogens and, for some patients, pioglitazone. d) Finally, we mention new robotic devices for hair transplant procedures and techniques for optimal follicular unit extraction.

      PubDate: 2017-03-25T05:31:26Z
       
  • FR- Exposición solar insuficiente y mortalidad global: ¿debemos
           recomendar o desaconsejar la exposición solar a nuestros pacientes'
    • Authors: M.T.
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): M.T. Monserrat-García, A. Ortíz-Prieto, P. Martín-Carrasco, J. Conejo-Mir-Sánchez


      PubDate: 2017-03-25T05:31:26Z
       
  • Granuloma aséptico facial idiopático. Utilidad de la
           ecografía cutánea
    • Authors: C.C.
      Abstract: Publication date: April 2017
      Source:Actas Dermo-Sifiliográficas, Volume 108, Issue 3
      Author(s): I. Vázquez-Osorio, C.C. Álvarez-Cuesta, L. Rodríguez-González, E. Rodríguez-Díaz


      PubDate: 2017-03-25T05:31:26Z
       
 
 
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