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Publisher: Elsevier   (Total: 3160 journals)

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Showing 1 - 200 of 3160 Journals sorted alphabetically
A Practical Logic of Cognitive Systems     Full-text available via subscription   (Followers: 9)
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 34, SJR: 1.655, CiteScore: 2)
Academic Radiology     Hybrid Journal   (Followers: 23, SJR: 1.015, CiteScore: 2)
Accident Analysis & Prevention     Partially Free   (Followers: 96, SJR: 1.462, CiteScore: 3)
Accounting Forum     Hybrid Journal   (Followers: 27, SJR: 0.932, CiteScore: 2)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 38, SJR: 1.771, CiteScore: 3)
Achievements in the Life Sciences     Open Access   (Followers: 5)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 7)
Acta Astronautica     Hybrid Journal   (Followers: 412, SJR: 0.758, CiteScore: 2)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 2)
Acta Biomaterialia     Hybrid Journal   (Followers: 27, SJR: 1.967, CiteScore: 7)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 2)
Acta de Investigación Psicológica     Open Access   (Followers: 3)
Acta Ecologica Sinica     Open Access   (Followers: 10, SJR: 0.18, CiteScore: 1)
Acta Haematologica Polonica     Free   (Followers: 1, SJR: 0.128, CiteScore: 0)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.661, CiteScore: 2)
Acta Materialia     Hybrid Journal   (Followers: 258, SJR: 3.263, CiteScore: 6)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.504, CiteScore: 1)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.542, CiteScore: 1)
Acta Oecologica     Hybrid Journal   (Followers: 12, SJR: 0.834, CiteScore: 2)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription  
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 3, SJR: 0.307, CiteScore: 0)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1, SJR: 1.793, CiteScore: 6)
Acta Poética     Open Access   (Followers: 4, SJR: 0.101, CiteScore: 0)
Acta Psychologica     Hybrid Journal   (Followers: 28, SJR: 1.331, CiteScore: 2)
Acta Sociológica     Open Access   (Followers: 1)
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.052, CiteScore: 2)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3, SJR: 0.374, CiteScore: 1)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.344, CiteScore: 1)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 1)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 6, SJR: 0.19, CiteScore: 0)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 3)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 6)
Acute Pain     Full-text available via subscription   (Followers: 14, SJR: 2.671, CiteScore: 5)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.53, CiteScore: 4)
Addictive Behaviors     Hybrid Journal   (Followers: 17, SJR: 1.29, CiteScore: 3)
Addictive Behaviors Reports     Open Access   (Followers: 8, SJR: 0.755, CiteScore: 2)
Additive Manufacturing     Hybrid Journal   (Followers: 10, SJR: 2.611, CiteScore: 8)
Additives for Polymers     Full-text available via subscription   (Followers: 22)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 154, SJR: 4.09, CiteScore: 13)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.167, CiteScore: 4)
Advanced Powder Technology     Hybrid Journal   (Followers: 17, SJR: 0.694, CiteScore: 3)
Advances in Accounting     Hybrid Journal   (Followers: 8, SJR: 0.277, CiteScore: 1)
Advances in Agronomy     Full-text available via subscription   (Followers: 14, SJR: 2.384, CiteScore: 5)
Advances in Anesthesia     Full-text available via subscription   (Followers: 28, SJR: 0.126, CiteScore: 0)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 2)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 10, SJR: 0.992, CiteScore: 1)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 11, SJR: 1.551, CiteScore: 4)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 24, SJR: 2.089, CiteScore: 5)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 14, SJR: 0.572, CiteScore: 2)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.61, CiteScore: 7)
Advances in Botanical Research     Full-text available via subscription   (Followers: 2, SJR: 0.686, CiteScore: 2)
Advances in Cancer Research     Full-text available via subscription   (Followers: 33, SJR: 3.043, CiteScore: 6)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 1.453, CiteScore: 2)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 1.992, CiteScore: 5)
Advances in Cell Aging and Gerontology     Full-text available via subscription   (Followers: 4)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 27, SJR: 0.156, CiteScore: 1)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.713, CiteScore: 1)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 10, SJR: 1.316, CiteScore: 2)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 29, SJR: 1.562, CiteScore: 3)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 19, SJR: 1.977, CiteScore: 8)
Advances in Computers     Full-text available via subscription   (Followers: 14, SJR: 0.205, CiteScore: 1)
Advances in Dermatology     Full-text available via subscription   (Followers: 14)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 12)
Advances in Digestive Medicine     Open Access   (Followers: 9)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 24)
Advances in Ecological Research     Full-text available via subscription   (Followers: 44, SJR: 2.524, CiteScore: 4)
Advances in Engineering Software     Hybrid Journal   (Followers: 28, SJR: 1.159, CiteScore: 4)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 8)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 46, SJR: 5.39, CiteScore: 8)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 1)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 9)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 58, SJR: 0.591, CiteScore: 2)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 16)
Advances in Genetics     Full-text available via subscription   (Followers: 16, SJR: 1.354, CiteScore: 4)
Advances in Genome Biology     Full-text available via subscription   (Followers: 8, SJR: 12.74, CiteScore: 13)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 1.193, CiteScore: 3)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 23, SJR: 0.368, CiteScore: 1)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 12, SJR: 0.749, CiteScore: 3)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 22)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.193, CiteScore: 0)
Advances in Immunology     Full-text available via subscription   (Followers: 35, SJR: 4.433, CiteScore: 6)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 1.163, CiteScore: 2)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 2, SJR: 1.938, CiteScore: 3)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 7, SJR: 0.176, CiteScore: 0)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 3)
Advances in Life Course Research     Hybrid Journal   (Followers: 8, SJR: 0.682, CiteScore: 2)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 8)
Advances in Marine Biology     Full-text available via subscription   (Followers: 18, SJR: 0.88, CiteScore: 2)
Advances in Mathematics     Full-text available via subscription   (Followers: 11, SJR: 3.027, CiteScore: 2)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6, SJR: 0.694, CiteScore: 2)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.158, CiteScore: 3)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 23)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 8)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.182, CiteScore: 0)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 3)
Advances in Oncobiology     Full-text available via subscription   (Followers: 1)
Advances in Organ Biology     Full-text available via subscription   (Followers: 1)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 17, SJR: 1.875, CiteScore: 4)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.174, CiteScore: 0)
Advances in Parasitology     Full-text available via subscription   (Followers: 5, SJR: 1.579, CiteScore: 4)
Advances in Pediatrics     Full-text available via subscription   (Followers: 24, SJR: 0.461, CiteScore: 1)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 12)
Advances in Pharmacology     Full-text available via subscription   (Followers: 16, SJR: 1.536, CiteScore: 3)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.574, CiteScore: 1)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.109, CiteScore: 1)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 10)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20, SJR: 0.791, CiteScore: 2)
Advances in Psychology     Full-text available via subscription   (Followers: 64)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 6, SJR: 0.371, CiteScore: 1)
Advances in Radiation Oncology     Open Access   (SJR: 0.263, CiteScore: 1)
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.101, CiteScore: 0)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 6)
Advances in Space Research     Full-text available via subscription   (Followers: 399, SJR: 0.569, CiteScore: 2)
Advances in Structural Biology     Full-text available via subscription   (Followers: 5)
Advances in Surgery     Full-text available via subscription   (Followers: 11, SJR: 0.555, CiteScore: 2)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 34, SJR: 2.208, CiteScore: 4)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 17)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 2.262, CiteScore: 5)
Advances in Water Resources     Hybrid Journal   (Followers: 46, SJR: 1.551, CiteScore: 3)
Aeolian Research     Hybrid Journal   (Followers: 6, SJR: 1.117, CiteScore: 3)
Aerospace Science and Technology     Hybrid Journal   (Followers: 345, SJR: 0.796, CiteScore: 3)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.42, CiteScore: 2)
African J. of Emergency Medicine     Open Access   (Followers: 6, SJR: 0.296, CiteScore: 0)
Ageing Research Reviews     Hybrid Journal   (Followers: 11, SJR: 3.671, CiteScore: 9)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 456, SJR: 1.238, CiteScore: 3)
Agri Gene     Hybrid Journal   (Followers: 1, SJR: 0.13, CiteScore: 0)
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 17, SJR: 1.818, CiteScore: 5)
Agricultural Systems     Hybrid Journal   (Followers: 31, SJR: 1.156, CiteScore: 4)
Agricultural Water Management     Hybrid Journal   (Followers: 41, SJR: 1.272, CiteScore: 3)
Agriculture and Agricultural Science Procedia     Open Access   (Followers: 3)
Agriculture and Natural Resources     Open Access   (Followers: 3)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 57, SJR: 1.747, CiteScore: 4)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.589, CiteScore: 3)
Air Medical J.     Hybrid Journal   (Followers: 6, SJR: 0.26, CiteScore: 0)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.19, CiteScore: 0)
Alcohol     Hybrid Journal   (Followers: 11, SJR: 1.153, CiteScore: 3)
Alcoholism and Drug Addiction     Open Access   (Followers: 10)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.604, CiteScore: 3)
Alexandria J. of Medicine     Open Access   (Followers: 1, SJR: 0.191, CiteScore: 1)
Algal Research     Partially Free   (Followers: 11, SJR: 1.142, CiteScore: 4)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.504, CiteScore: 1)
Allergology Intl.     Open Access   (Followers: 5, SJR: 1.148, CiteScore: 2)
Alpha Omegan     Full-text available via subscription   (SJR: 3.521, CiteScore: 6)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 9, SJR: 0.201, CiteScore: 1)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 51, SJR: 4.66, CiteScore: 10)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 4, SJR: 1.796, CiteScore: 4)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 4, SJR: 1.108, CiteScore: 3)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 6)
American Heart J.     Hybrid Journal   (Followers: 50, SJR: 3.267, CiteScore: 4)
American J. of Cardiology     Hybrid Journal   (Followers: 54, SJR: 1.93, CiteScore: 3)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 45, SJR: 0.604, CiteScore: 1)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 10)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.524, CiteScore: 3)
American J. of Human Genetics     Hybrid Journal   (Followers: 34, SJR: 7.45, CiteScore: 8)
American J. of Infection Control     Hybrid Journal   (Followers: 28, SJR: 1.062, CiteScore: 2)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 35, SJR: 2.973, CiteScore: 4)
American J. of Medicine     Hybrid Journal   (Followers: 47)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3, SJR: 1.967, CiteScore: 2)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 216, SJR: 2.7, CiteScore: 4)
American J. of Ophthalmology     Hybrid Journal   (Followers: 66, SJR: 3.184, CiteScore: 4)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 5, SJR: 0.265, CiteScore: 0)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.289, CiteScore: 1)
American J. of Otolaryngology     Hybrid Journal   (Followers: 25, SJR: 0.59, CiteScore: 1)
American J. of Pathology     Hybrid Journal   (Followers: 28, SJR: 2.139, CiteScore: 4)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 28, SJR: 2.164, CiteScore: 4)
American J. of Surgery     Hybrid Journal   (Followers: 38, SJR: 1.141, CiteScore: 2)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.767, CiteScore: 1)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 7)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.144, CiteScore: 3)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 62, SJR: 0.138, CiteScore: 0)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 17, SJR: 0.411, CiteScore: 1)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 3, SJR: 0.277, CiteScore: 0)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription  
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 5, SJR: 4.849, CiteScore: 10)
Analytica Chimica Acta     Hybrid Journal   (Followers: 42, SJR: 1.512, CiteScore: 5)
Analytical Biochemistry     Hybrid Journal   (Followers: 181, SJR: 0.633, CiteScore: 2)
Analytical Chemistry Research     Open Access   (Followers: 12, SJR: 0.411, CiteScore: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 11)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 2)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 23, SJR: 0.683, CiteScore: 2)
Angiología     Full-text available via subscription   (SJR: 0.121, CiteScore: 0)
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1, SJR: 0.111, CiteScore: 0)
Animal Behaviour     Hybrid Journal   (Followers: 199, SJR: 1.58, CiteScore: 3)

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Journal Cover
Advances in Planar Lipid Bilayers and Liposomes
Journal Prestige (SJR): 0.109
Citation Impact (citeScore): 1
Number of Followers: 3  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1554-4516
Published by Elsevier Homepage  [3160 journals]
  • Series Page
    • Abstract: Publication date: 2015
      Source:Advances in Planar Lipid Bilayers and Liposomes, Volume 22


      PubDate: 2015-08-12T13:41:49Z
       
  • Stimuli-Sensitive Liposomes: Lipids as Gateways for Cargo Release
    • Authors: Mathias Viard; Anu Puri
      Abstract: Publication date: Available online 9 July 2015
      Source:Advances in Planar Lipid Bilayers and Liposomes
      Author(s): Mathias Viard , Anu Puri
      Lipids are integral part of cell membranes and play a vital role in biological processes such as membrane fusion, exocytosis, cell signaling, and disease progression. Uniquely defined chemical structures of lipids as well as their assembly in the aqueous environment are often known to dictate their biological activity. Some of these features of lipids have been exploited to develop carriers for drugs, bioactive molecules, and nucleic acids. Lipid-based nanocarriers (specifically liposomes) have claimed their status in the field of cancer nanomedicine. Liposomes, the longest studied nanocarriers (at least since four decades), are currently used in the clinics for delivery of drugs to treat certain types of cancers though not at their full potential. Further development in this field by utilizing site-specific targeting molecules and/or efforts to generate tunable liposomes can be predicted to enhance their suitability in the clinical settings. In general, the chemical and biophysical properties of lipid molecules primarily dictate the development of tunable (stimuli-sensitive) liposomes. Research activities toward stimuli-responsive liposomes can be broadly classified into internal (pH, redox, and enzyme) or external (heat, light and/or magnetic field, and ultrasound) stimulus. In this review, we will discuss the current status and latest developments in the field of stimuli-sensitive liposomes. The topics covered in this review will include (i) a brief summary of liposomes used in the clinics, stimuli-sensitive liposomes; (ii) triggering events by inclusion of coagents in the liposomes; (iii) triggering based on properties of lipids to yield heat, light, pH, redox, and enzyme-activatable liposomes; and (iv) limitations and future directions for the development of clinically viable stimuli-responsive liposomes.

      PubDate: 2015-07-10T09:02:36Z
       
  • Biomembrane Organization and Function: The Decisive Role of Ordered Lipid
           Domains
    • Authors: Joaquim Catarina; A.C. Antunes Filipa Santos Rodrigo F.M. Almeida
      Abstract: Publication date: Available online 9 July 2015
      Source:Advances in Planar Lipid Bilayers and Liposomes
      Author(s): Joaquim T. Marquês , Catarina A.C. Antunes , Filipa C. Santos , Rodrigo F.M. de Almeida
      There has been a great effort to study lipid lateral organization in biomembranes in the past decades, in order to unravel the structural basis and functional significance of membrane lipid domains. However, in both respects fundamental doubts still persist, and recent results have widened this topic well beyond lipid rafts. In particular, the detection of sphingolipid-enriched gel domains in the yeast Saccharomyces cerevisiae plasma membrane, which are not the prototypical liquid ordered, sterol-enriched lipid rafts, will be described. The critical role of ordered lipid domains will be demonstrated with biophysical studies of membrane lipid organization in living cells and in model systems, concerning mammalian and fungal membranes. Membrane interactions with different types of bioactive molecules will be briefly presented, including endogenous molecules such as the hormone epinephrine or membrane proteins, as well as drugs, including anticancer and antitubercular compounds. Strategies to tackle the complexity of living cell membranes will be discussed, in an attempt to reach a compromise between lipid lamellar phases in artificial or reconstituted systems and observations in living cells. The development of new and improved biomimetic systems might provide answers to some of the open questions in the lipid domains field. Therefore, new lipid bilayer membrane models containing lipid domains stably formed on a conducting support (gold), where powerful surface and electrochemical techniques can be employed, will also be presented. The redox behavior of the catecholamine hormone epinephrine studied in such system showed that the lipid bilayer has a crucial role for the hormone chemical stability.

      PubDate: 2015-07-10T09:02:36Z
       
  • Membrane Microvesiculation and its Suppression
    • Authors: Veronika
      Abstract: Publication date: Available online 2 July 2015
      Source:Advances in Planar Lipid Bilayers and Liposomes
      Author(s): Veronika Kralj-Iglič
      Membrane microvesiculation is a common process in cells. Membrane constituents undergo lateral redistribution coupled to the change in local membrane curvature. Thin necks that are formed in this process can be torn by mechanical stress and membrane-enclosed fragments that contain various biologically active molecules become more or less free to move with fluids. Released vesicles are small in size (micrometer down to tens of nanometers). They interact with distant cells and thereby present an intercellular communication system which plays important physiological role in organisms. Micro and nanovesicles (NVs) can be isolated from body fluids. It was found that the concentration of NVs is increased in isolates from blood of patients with different diseases (e.g., cancer, inflammation, infection, thromboembolic diseases) indicating an increased vesiculability of blood cells. Here, we present some mechanisms of microvesiculation of biological membranes and suggest a possible mechanism for suppression of microvesiculation by a mediated attractive interaction between membranes.

      PubDate: 2015-07-06T05:12:09Z
       
  • Series Page
    • Abstract: Publication date: 2015
      Source:Advances in Planar Lipid Bilayers and Liposomes, Volume 21


      PubDate: 2015-04-02T02:50:56Z
       
  • Microscopy of Model Membranes: Understanding How Bcl-2 Proteins Mediate
           Apoptosis
    • Authors: Kushal Kumar; Das Joseph Unsay Ana Garcia-Saez
      Abstract: Publication date: Available online 7 February 2015
      Source:Advances in Planar Lipid Bilayers and Liposomes
      Author(s): Kushal Kumar Das , Joseph D. Unsay , Ana J. Garcia-Saez
      Apoptosis is a form of programmed cell death that plays an important role in key biological processes like development of organisms, the correct functioning of the immune system, and the maintenance of the cellular homeostasis. Dysregulation in the apoptotic pathway leads to diseases like cancer or neurodegenerative disorders. The proteins of the B-cell lymphoma 2 (Bcl-2) family are key regulators of mitochondrial outer membrane permeabilization (MOMP) during apoptosis, which is a critical step in the cell's commitment to death. However, their mechanism of action is still under intense investigation. Here, we discuss how microscopy approaches applied to model membranes are used to understand the intrinsic apoptotic pathway involving MOMP. We describe how model membranes mimicking the outer mitochondrial membrane (LUVs, GUVs, SLB) are used to understand the mechanism of Bcl-2-mediated apoptosis using state-of-the-art techniques like atomic force microscopy and fluorescence correlation spectroscopy. These studies have revealed interesting features like the role of membrane in altering the affinity of Bcl-2 proteins, Bax and Bak proapoptotic activity, mechanistic differences between pro- and antiapoptotic members, and the critical helices involved in pore formation by Bax.

      PubDate: 2015-02-12T01:36:21Z
       
  • Development of Polymer/Nanodiamond Composite Coatings to Control Cell
           Adhesion, Growth, and Functions
    • Authors: Milena Keremidarska; Kamelia Hristova; Todor Hikov; Ekaterina Radeva; Dimitar Mitev; Ivailo Tsvetanov; Radina Presker; Damjana Drobne; Barbara Drašler; Sara Novak; Veno Kononenko; Kristina Eleršič; Lilyana Pramatarova; Natalia Krasteva
      Pages: 1 - 26
      Abstract: Publication date: Available online 7 February 2015
      Source:Advances in Planar Lipid Bilayers and Liposomes
      Author(s): Milena Keremidarska , Kamelia Hristova , Todor Hikov , Ekaterina Radeva , Dimitar Mitev , Ivailo Tsvetanov , Radina Presker , Damjana Drobne , Barbara Drašler , Sara Novak , Veno Kononenko , Kristina Eleršič , Lilyana Pramatarova , Natalia Krasteva
      The identification of biomaterials that support appropriate cellular attachment, proliferation, and functions is critical for tissue engineering and cell therapy. There is a growing interest in functional organic/inorganic composites where a small amount of nanometer-sized material yields better physicochemical properties for cells to attach, grow, and differentiate. In this work, we prepared polymer/nanodiamond composite layers based on hexamethyldisiloxane and detonation-generated nanodiamond (DND) particles, in which the particles were either embedded into a polymer matrix or deposited on the preliminary formed plasma-polymerized (PP) layer. The surface properties of composites, such as roughness and wettability, as well as adhesion, growth, and functions of osteosarcoma MG-63 cells and primary rat mesenchymal stem cells were studied. We aimed to investigate the influence of the incorporation methods of DND into the polymer on the material surface properties and the cell response in order to control them by manipulating diamond-containing composite surfaces. We found differences between both composites in respect to their physicochemical properties and to the cell behavior suggesting that the method of particle incorporation into polymers should be taken in account during the development of new biomaterials for a specific application.

      PubDate: 2015-02-12T01:36:21Z
      DOI: 10.1016/bs.adplan.2015.01.001
       
  • Tethered Phospholipid Bilayer Membranes: An Interpretation of the
           Electrochemical Impedance Response
    • Authors: Gintaras Valincius; Mindaugas Mickevicius
      Pages: 27 - 61
      Abstract: Publication date: Available online 9 February 2015
      Source:Advances in Planar Lipid Bilayers and Liposomes
      Author(s): Gintaras Valincius , Mindaugas Mickevicius
      In this study, we discuss applications of the electrochemical impedance (EI) response of tethered bilayer membranes (tBLMs) in protein (peptide)/phospholipid membrane interaction studies. Because of highly asymmetric geometry, tBLMs exhibit unique EI response, which cannot be modeled by simple equivalent circuits consisting of capacitors and resistors. Special functions describe the characteristic features of EI spectra. They take into account the structural and the dielectric properties of the tBLMs. The analysis of the EI response provides the theoretical background for the utility of tBLMs as bioanalytical sensors for the membrane-damaging agents, such as pore-forming toxins. We demonstrate that the magnitude and frequency of the minimum of the negative of the phase as well as the modulus of impedance are the parameters indicative of the extent of the membrane damage and may be used to estimate the defect density in bilayers. The precision of such estimates is highly dependent on the knowledge of the physical properties of the submembrane reservoir separating phospholipid bilayer and solid surface. Clustering of the defects affects the EI response in a unique way, which may be used for the qualitative analysis of protein–membrane interactions.

      PubDate: 2015-02-12T01:36:21Z
      DOI: 10.1016/bs.adplan.2015.01.003
       
  • Effect of Lipid Bilayer Composition on Membrane Protein Association
    • Authors: Aiswarya B. Pawar; Xavier Prasanna; Durba Sengupta
      Pages: 43 - 63
      Abstract: Publication date: Available online 15 July 2015
      Source:Advances in Planar Lipid Bilayers and Liposomes
      Author(s): Aiswarya B. Pawar, Xavier Prasanna, Durba Sengupta
      Diverse cellular functions are supported by membrane protein assemblies associated with the cell membrane. Although considered to be protein-mediated, membrane components are now being recognized as critical in modulating and sometime dictating function. This chapter discusses the effect of the lipid bilayer, in particular its composition on membrane protein organization. Computational methods have been successful in quantifying transmembrane protein association and general features of dimerization profiles are explored. Understanding the molecular basis of the interactions has lead to the recognition of the lipophobic effects. These nonspecific effects include those that arise from membrane perturbations and lipid chain packing and have been shown to modulate the energetics as well as the structural characteristics of membrane protein dimerization. In addition, specific interactions arising from direct protein–lipid interactions and protein–cholesterol interactions have been suggested to influence membrane protein association. We summarize here a few examples highlighting the role of the lipid bilayer on membrane protein organization.

      PubDate: 2015-07-18T23:25:38Z
      DOI: 10.1016/bs.adplan.2015.06.001
       
  • Membrane-Bound Conformations of Antimicrobial Agents and Their Modes of
           Action
    • Authors: Upayan Baul; Satyavani Vemparala
      Pages: 97 - 128
      Abstract: Publication date: Available online 21 July 2015
      Source:Advances in Planar Lipid Bilayers and Liposomes
      Author(s): Upayan Baul, Satyavani Vemparala
      All antimicrobial agents are inherently membrane active and the complex interactions involved can lead to considerable conformational changes in the agents, while also inducing structural rearrangements of membrane lipids. Such structural modifications can trigger series of events enabling the agent to affect the structural integrity of the microbial membrane or translocate to the interior of the microbial cell. Therapeutic use of such agents requires a detailed understanding of the interaction of such antimicrobial agents with bacterial membranes. It is of interest to note that despite the existence of diversity in chemical compositions of many naturally occurring antimicrobial agents, the possible number of secondary structure conformations that they possess, either in solution or in membrane environment, is very small in number. In spite of considerable effort put in to probe the relationship between secondary structure and mode of antimicrobial action over the past two decades through experiments and simulations, a detailed understanding of the same is yet to be achieved. Furthermore, recent experimental and simulation results suggest that built-in well-defined secondary conformations such as α-helix or β-sheet may not be the essential feature of potent antimicrobial agents, but rather the ability of these agents to acquire amphiphilic conformations, involving the spatial separation of charged and hydrophobic moieties, near the bacterial membrane. In this chapter, we review different antimicrobial agents that have been the focus of various studies with special emphasis on computer simulations and their role in understanding the interactions of biomimetic antimicrobial polymers, based on methacrylate copolymers, with bacterial membranes.

      PubDate: 2015-07-23T03:19:29Z
      DOI: 10.1016/bs.adplan.2015.06.006
       
  • Optical Microscopy of Giant Vesicles as a Tool to Reveal the Mechanism of
           Action of Antimicrobial Peptides and the Specific Case of Gomesin
    • Authors: Karin A. Riske
      Pages: 99 - 129
      Abstract: Publication date: Available online 7 February 2015
      Source:Advances in Planar Lipid Bilayers and Liposomes
      Author(s): Karin A. Riske
      Antimicrobial peptides are part of the immune defense system involved in protection against pathogenic agents, such as bacteria and fungi. Most of them are cationic and amphipathic, an essential feature that confers them special affinity for their main target: the lipid matrix of the cell membrane of microorganisms. Their activity as biocides depends on perturbation of the membrane barrier, either by causing the opening of pores or by inducing membrane disintegration. Lipid bilayers have been widely used as biomimetic system of the complex cell membrane and were essential in providing mechanistic detail on the mode of action of antimicrobial peptides. In particular, giant unilamellar vesicles (GUVs) are cell-sized lipid vesicles that can be individually followed under a microscope, providing a direct way to correlate peptide binding with membrane permeabilization and domain formation. Here, an overview on the contributions of optical microscopy to reveal the mode of action of several membrane-active peptides is given and discussed. A complete characterization of the mechanism of action of the antimicrobial peptide gomesin from the Brazilian spider Acanthoscurria gomesiana developed by our group in recent works is presented, combining optical microscopy observation of GUVs and complementary techniques on large unilamellar vesicles, such as isothermal titration calorimetry, light scattering, and a leakage assay of an entrapped fluorescent dye.

      PubDate: 2015-02-12T01:36:21Z
      DOI: 10.1016/bs.adplan.2014.12.001
       
  • Phenomenology Based Multiscale Models as Tools to Understand Cell Membrane
           and Organelle Morphologies
    • Authors: Ramakrishnan Natesan; Ravi Radhakrishnan
      Pages: 129 - 175
      Abstract: Publication date: Available online 16 July 2015
      Source:Advances in Planar Lipid Bilayers and Liposomes
      Author(s): N. Ramakrishnan, Ravi Radhakrishnan
      An intriguing question in cell biology is “how do cells regulate their shape?” It is commonly believed that the observed cellular morphologies are a result of the complex interaction among the lipid molecules (constituting the cell membrane), and with a number of other macromolecules, such as proteins. It is also believed that the common biophysical processes essential for the functioning of a cell also play an important role in cellular morphogenesis. At the cellular scale—where typical dimensions are in the order of micrometers—the effects arising from the molecular scale can either be modeled as equilibrium or nonequilibrium processes. In this chapter, we discuss the dynamically triangulated Monte Carlo technique to model and simulate membrane morphologies at the cellular scale, which in turn can be used to investigate several questions related to shape regulation in cells. In particular, we focus on two specific problems within the framework of isotropic and anisotropic elasticity theories: namely, (i) the origin of complex, physiologically relevant, membrane shapes due to the interaction of the membrane with curvature remodeling proteins, and (ii) the genesis of steady state cellular shapes due to the action of nonequilibrium forces that are generated by the fission and fusion of transport vesicles and by the binding and unbinding of proteins from the parent membrane.

      PubDate: 2015-07-18T23:25:38Z
      DOI: 10.1016/bs.adplan.2015.06.004
       
  • Steric Stabilizers for Cubic Phase Lyotropic Liquid Crystal
           Nanodispersions (Cubosomes)
    • Authors: Josephine Y.T. Chong; Xavier Mulet; Ben J. Boyd; Calum J. Drummond
      Pages: 131 - 187
      Abstract: Publication date: Available online 4 February 2015
      Source:Advances in Planar Lipid Bilayers and Liposomes
      Author(s): Josephine Y.T. Chong , Xavier Mulet , Ben J. Boyd , Calum J. Drummond
      Lyotropic liquid crystalline nanostructured particles, such as cubosomes, have grown in popularity as drug delivery systems in the last few years. These systems require steric stabilizers to maintain colloidal stability in an aqueous medium, with Pluronic®F127, a block copolymer, being the most commonly employed stabilizer. However, in recent years, alternative, more effective stabilizers, as well as rationally designed systems with opportunities for further biofunctionalization have been reported. The purpose of this chapter is to collate and collectively interpret studies in the field of steric stabilization of this important emerging class of nanoparticles for drug and medical imaging agent delivery.

      PubDate: 2015-02-06T00:50:58Z
      DOI: 10.1016/bs.adplan.2014.11.001
       
 
 
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