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Publisher: Elsevier   (Total: 3043 journals)

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Showing 1 - 200 of 3043 Journals sorted alphabetically
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 20, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 18, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 83, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 23, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 27, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 4)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 5, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 333, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 3)
Acta Biomaterialia     Hybrid Journal   (Followers: 25, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 1)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 225, SJR: 3.683, h-index: 202)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.615, h-index: 21)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 9, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription   (Followers: 1)
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 3, SJR: 0.311, h-index: 16)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 2)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 23, SJR: 1.365, h-index: 73)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 4)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 4, SJR: 0.383, h-index: 19)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 2)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 5, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 4, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 3)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 5)
Additive Manufacturing     Hybrid Journal   (Followers: 8, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 20)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 134, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 16, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 9, SJR: 0.299, h-index: 15)
Advances in Agronomy     Full-text available via subscription   (Followers: 15, SJR: 2.071, h-index: 82)
Advances in Anesthesia     Full-text available via subscription   (Followers: 25, SJR: 0.169, h-index: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 3)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 6, SJR: 1.054, h-index: 35)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 10, SJR: 0.801, h-index: 26)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 22, SJR: 1.286, h-index: 49)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
Advances in Botanical Research     Full-text available via subscription   (Followers: 3, SJR: 0.619, h-index: 48)
Advances in Cancer Research     Full-text available via subscription   (Followers: 25, SJR: 2.215, h-index: 78)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 0.9, h-index: 30)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 2.139, h-index: 42)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 24, SJR: 0.183, h-index: 23)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 10, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 16, SJR: 0.223, h-index: 22)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 11)
Advances in Digestive Medicine     Open Access   (Followers: 4)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Ecological Research     Full-text available via subscription   (Followers: 42, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 25, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 7)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 40, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 3)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 47, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 15)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 21, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.497, h-index: 31)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 26)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 35, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 3, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 5)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 4)
Advances in Life Course Research     Hybrid Journal   (Followers: 8, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 2)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Marine Biology     Full-text available via subscription   (Followers: 16, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 22)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 10)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 4)
Advances in Oncobiology     Full-text available via subscription   (Followers: 3)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 24, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 13)
Advances in Pharmacology     Full-text available via subscription   (Followers: 15, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 7, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 4)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 19, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 60)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 2, SJR: 0.1, h-index: 2)
Advances in Space Research     Full-text available via subscription   (Followers: 345, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 8)
Advances in Surgery     Full-text available via subscription   (Followers: 7, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 30, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 16)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 43, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 5, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 310, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 5, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 8, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 408, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 30, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 38, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access  
Agriculture and Natural Resources     Open Access   (Followers: 1)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 53, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 5, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 9, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 6)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access  
Algal Research     Partially Free   (Followers: 8, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 4, SJR: 0.776, h-index: 35)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 7, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 48, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 5)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 3)
American Heart J.     Hybrid Journal   (Followers: 48, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 45, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 38, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 6, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 16, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 31, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 24, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 33, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 46, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 187, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 54, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 3)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 23, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 26, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 21, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 34, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 5)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 55, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 9)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 2, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 38, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 164, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 8, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 11)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 1)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 22, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access  
Animal Behaviour     Hybrid Journal   (Followers: 158, SJR: 1.907, h-index: 126)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 5, SJR: 1.151, h-index: 83)
Animal Reproduction Science     Hybrid Journal   (Followers: 5, SJR: 0.711, h-index: 78)
Annales d'Endocrinologie     Full-text available via subscription   (Followers: 1, SJR: 0.394, h-index: 30)
Annales d'Urologie     Full-text available via subscription  
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (SJR: 0.177, h-index: 13)
Annales de Chirurgie de la Main et du Membre Supérieur     Full-text available via subscription  
Annales de Chirurgie Plastique Esthétique     Full-text available via subscription   (Followers: 2, SJR: 0.354, h-index: 22)
Annales de Chirurgie Vasculaire     Full-text available via subscription   (Followers: 1)

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Journal Cover Advances in Oncobiology
  [3 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1569-254X
   Published by Elsevier Homepage  [3043 journals]
  • List of contributors
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 3



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 1 Introduction
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 3



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 2 Pathology of prostate cancer
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 3



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 3 Animal model systems for the study of prostate cancer
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 3



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 4 Tumor markers for prostate cancer
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 3



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 5 Molecular biology of prostate cancer Tumor Suppressor Genes
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 3



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 6 Apoptosis and prostate cancer
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 3



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 7 Angiogenesis in prostate cancer
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 3



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 8 Molecular progression of prostate cancer
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 3



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 9 biology of prostate cancer bone marrow metastasis
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 3



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 10 Integrins in prostate cancer metastasis
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 3



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 11 Neoadjuvant hormonal therapy prior to radical prostatectomy
           Promises and Pitfalls
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 3



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 12 Current management of hormone-refractory prostate cancer
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 3



      PubDate: 2012-12-17T18:13:54Z
       
  • List of contributors
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 2



      PubDate: 2012-12-17T18:13:54Z
       
  • Differentiation and breast cancer development
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 2



      PubDate: 2012-12-17T18:13:54Z
       
  • Growth factor signal transduction and hormone independence in breast
           cancer
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 2



      PubDate: 2012-12-17T18:13:54Z
       
  • Biology of high risk benign breast lesions
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 2



      PubDate: 2012-12-17T18:13:54Z
       
  • Estrogen receptor variants in early breast disease and breast cancer
           progression
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 2

      As a downstream mediator of estrogen action, the ER can have a number of pleiotropic effects on a variety of cell types. The critical importance of estrogen in both normal and breast cancer growth has made the ER a matter of intense study, and still its complete mode of action is unclear. One of the discoveries to come out of recent work is the finding that the ER is often altered at the RNA level in both normal and malignant breast tissue. When the interaction of these variants with the growing number of regulators of wild-type ER activity are studied in detail, we may get a clearer picture of the role of variant ERs in breast cancer disease and progression.

      PubDate: 2012-12-17T18:13:54Z
       
  • Biological basis of genetic predisposition to breast cancer
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 2

      In summary, there have indeed been major breakthroughs in the identification of multiple genetic aberrations in breast cancer. These include germ-line mutations in familial disease, genes that confer increased susceptibility to many different cancers including breast cancer, and genetic aberrations observed only in breast cancers. The large number of aberrations reported may seem perplexing. However, strategies which identify how they fit into models for the etiology and evolution of this disease and how familial genes may be involved in sporadic breast cancer are beginning to appear and will continue to be a challenge for the future.

      PubDate: 2012-12-17T18:13:54Z
       
  • The clinicopathologic significance of genetic instability in breast
           carcinoma progression
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 2



      PubDate: 2012-12-17T18:13:54Z
       
  • The histopathology of transgenes and knockouts in the mammary gland
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 2



      PubDate: 2012-12-17T18:13:54Z
       
  • Immune facilitation of breast cancer
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 2



      PubDate: 2012-12-17T18:13:54Z
       
  • A history of cancer of the male breast
    • Abstract: 1999
      Publication year: 1999
      Source:Advances in Oncobiology, Volume 2



      PubDate: 2012-12-17T18:13:54Z
       
  • List of contributors
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 1 Pathobiology of Neoplasia
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1

      We began our discussion of neoplasia with two unifying definitional concepts. First it was asserted that all forms of neoplasia can be seen as a failure of somatic tissues to differentiate appropriately. This failure was caused by arrested maturation of organ determined stem cell progeny which resulted in an immature or incompletely differentiated phenotype. From this fundamental concept it was possible to understand the histopathology of diverse forms of neoplasia, to derive an explanation for benign versus malignant phenotype, to theorize mechanisms which help explain invasion and metastasis, and even to account for the distinctive clinical features of neoplastic diseases. The second unifying concept was that the primary, and likely causal, structural lesions inherent to neoplastic diseases involve the genome, either in the germline, in the somatic tissues, or in both. This genetic pathology was heterogenous but, not unexpectedly, it induced abnormal expression of specific genes which control tissue growth and differentiation. Some of these genes mediate responses to environmental stimuli whereas others regulate critical aspects of cell proliferation. The net effect of the genetic alterations, at any rate, is to impose a proliferative—and thereby incompletely differentiated—phenotype. Further, the extent of genetic pathology is directly related to degree of differentiation abnormality, and hence clinical behavior. Thus, the inextricable connection between morphologic pathology and genetic pathology in neoplasia is made whole. Finally, with the discovery of gene products, such as p53, which function to maintain genomic structure, we can theorize that genetic instability accounts for the process of tumor progression, in which phenotypic evolution within a neoplasm occurs over time. The catalogue of genetic lesions involved in neoplasia is far from complete, as is the spectrum of consequences at the level of cell proliferation and differentiation. Moreover, we are a long way from understanding all of the mechanisms by which the genome becomes destabilized. Thus, our ability to predict whether neoplasia will arise, whether a neoplasm is likely to be lethal, or how it will respond to therapy, remains imperfect. Nevertheless, our understanding of the matrix of events that control the dynamics of normal differentiation and proliferation provides us with an organizational framework which can guide research efforts toward elucidating the detailed mechanisms which determine neoplastic development and behavior.

      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 2 Cancer induction by ionizing radiation
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1

      Ionizing radiation at high doses is known human carcinogen. Numerous population studies involving military, medical, and occupational uses of radiation clearly show that leukemia and a variety of solid tumors may be induced by radiation. However, at low doses of radiation, typically encountered in diagnostic radiology and nuclear medicine, the evidence for cancer causation is much less compelling. Most epidemiological studies are inconsistent. Only a few studies suggest a significant association between radiation and cancer. Even in these investigations, the causal nature of such associations and the levels of risk remain uncertain. Radiation risks for cancer have been based primarily on studies of Japanese survivors of the atomic bombings. Extrapolation of data derived from these studies, using a linear no-threshold model, has been the basis for predicting cancer risk at low doses. The derived risk estimates suggest that radiodiagnostic studies, including nuclear medicine and X-ray examinations, are associated with small risks for cancer. Radiotherapy for cancer, which involves substantially higher doses, are associated with higher risks, but these risks are still very small considering the benefits derived from the treatments.

      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 3 Environmental causes of cancer
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 4 Progestin regulation of cellular proliferation
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1

      Progestins have diverse effects on cell proliferation in progestin target tissues which are developmentally regulated as well as being species- and cell type-specific. Both stimulatory and inhibitory effects are well documented but it is still unclear whether the stimulatory effects are sustained, i.e., whether they result in continued rounds of cell replication or result in transient effects on a given cell population, inducing a single round of replication before cells undergo terminal differentiation. The inhibitory effects have been more clearly defined, particularly for endometrial epithelium in vivo and for both endometrial and breast carcinoma cells in vitro. Progestin-induced inhibition of cell proliferation results from a block in cell cycle progression in early G1 phase immediately after mitosis indicating that progestins inhibit the production and/or functions of genes critical to progression through early G1 phase. These genes have not been identified but candidates include the proto-oncogene c-myc and the G1 cyclins, particularly cyclin D1 and its kinase partners. Recent studies employing human mammary carcinoma cells as models have documented a progestin-induced stimulation of cell cycle progression in G1 phase. This effect appears to be confined to cells that are already in G1 phase and leads to accelerated progression through this phase of the cell cycle. Since other phases appear unaffected, the resultant effect is a significantly reduced cell generation time, i.e., an increased rate of cell proliferation. Whether or not this is a good model for the stimulatory effects of progestins in vivo remains to be established. Studies of changes in gene expression accompanying increased G1 transit have demonstrated that this effect is preceded by induction of c-myc and cyclin D1. Since delayed administration of a progestin antagonist inhibited cell cycle progression and cyclin D1 induction and the effects of progestins were mimicked by inducible expression of a transfected cyclin D1 construct, there is strong evidence that transcriptional activation of cyclin D1 is causal for progestin stimulation of cell proliferation. These data, generated from well-characterized experimental models in vitro, have facilitated progress in our understanding of mechanisms of progestin action. The hypotheses developed from these systems urgently need to be validated in a broader spectrum of progestin target tissues including female reproductive organs in vivo. Such data are essential to an understanding of the further physiology of progestin action and the optimal use of progestins in the management of human disease.

      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 5 Tumor angiogenesis and its control by tumor suppressor genes
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 6 The role of gap junctional intercellular communication in
           neoplasia
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1

      Gap junctions consist of clusters of channels embedded in the plasma membranes of adjacent cells that directly link the two cell interiors and that permit the cell-to-cell exchange of small (< 1,000 Da) cytoplasmic molecules and ions. This transfer has been called gap junctional intercellular communication (GJIC). The proteins forming the channels are known as connexins. Many connexin genes have been cloned, but the regulation of their expression is poorly understood. The proposed roles of GJIC include tissue homeostasis, electrical synapsing, coordination of cellular responses to hormones, regulation of embryonic development, and regulation of cellular growth and phenotypic expression. This latter function is especially relevant to understanding dysregulated growth in the neoplastic cell. Growth regulatory factors may be exchanged between cells via gap junctions. A reduction in gap junction formation and function is commonly observed in neoplastic cells and in cells treated with certain nongenotoxic, growth-enhancing carcinogens. The inhibition of GJIC is thought to isolate cells from the growth regulatory influences of their neighbors and to facilitate dysrgulated growth. The restoration of GJIC in neoplastic cells has been achieved genetically by connexin gene transfection and pharmacologically by treatment with vitamins, hormones, and other agents. This enhancement has resulted in reduced neoplastic cell growth and tumorigenicity in experimental animals. Such results suggest that the stimulation of GJIC should be pursued as a potential antineoplastic approach.

      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 7 Cell adhesion and metastasis: Molecular mechanisms
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1

      In order to metastasize via the blood a malignant cell must leave the primary tumor, gain access to the circulatory system, enter the tissues and establish the secondary tumor, all under the watchful eye of the host defense systems. Most of these stages involve adhesive interactions of some type. Migration from the primary tumor might involve decreased homotypic adhesion to other malignant cells within the mass, while movement itself requires regulated changes in cell-substrate adhesiveness. One feasible explanation for locomotion is that the moving cell makes adhesions at its front end and breaks them down at its rear as it projects itself forward. Penetration of blood vessels may first require binding to the vessel wall (basement membrane) after which detachment (from the lining endothelium) would be necessary to utilize the medium of the circulatory system for spread to distant sites. Within the blood, collisions will take place with host cells which could include cytotoxic leukocytes and platelets. Avoidance of adhesive interactions with defense cells might enhance metastatic outcome, while promotion of binding to platelets might have a similar effect through embolus development and subsequent trapping in small vessels. Extravasation from the blood will require some form of lodgement, which may be purely mechanical (e.g., impounding of a tumor cell-platelet embolus which is of a diameter larger than that of the vessel through which it is coursing) or mediated by molecular interactions between the circulating malignant cell and the lining epithelium. Movement out of the vessel in the latter case will require detachment from the endothelium and subsequent regulation of adhesion/de-adhesion processes as the cell moves through the stroma to ultimately establish the secondary tumor. It should be immediately clear from the scenario outlined above that the involvement of adhesion in the metastatic process is far from simple, and that at times both increased and decreased adhesiveness may be advantageous. Whether the metastasizing cell is adhering to other malignant cells or normal tissues cells (e.g., endothelium; host defense cells) or to ECM components is clearly also of importance since different interactions are likely to be involved and the metastatic outcomes can be markedly different. A comprehensive understanding of all of these aspects of the metastatic process would seem essential before valid generalizations can be made concerning the role of cell adhesion in malignant tumor spread.

      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 8 Ras: Processor of vital signals
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1

      The pivotal role of Ras as a transducer of vital signals is well established. As such, aberrant Ras signaling is associated with cancer, neurofibromatosis, and Alzheimer's disease. This realization could make detection of mutated ras a useful diagnostic and prognostic tool. Exploiting the biochemical properties of Ras has made interfering with Ras activity a potential clinical option and dissection of the relative contribution of each signaling pathway emanating from Ras will certainly provide additional targets for clinical intervention.

      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 9 Human cytokines
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1

      Human cytokines represent a new class of polypeptide hormones which are produced by and targeted to not only the cells of the immune system but many others. Cytokines are key players involved in the modulation of the immune system, the maintenance of homeostasis, and hematopoiesis. Most cytokines possess many overlapping activities as evident by their in vitro activities as well as their in vivo activities. In the past few years, the identification of new factors, the characterization of their activities in vitro, and the identification of their receptors has increased rapidly. The detection of cytokines in different disease states may hold promise in diagnosis. The role of these molecules in the therapy of the disease is already evident. The utilization of human cytokines and their receptors in rational drug design has widened the scope of the current biotechnology industry.

      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 10 Immunity to cancer Cytotoxic lymphocytes, interleukin-2, and
           the tumor necrosis factor superfamily
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 11 Quantitative analysis of nuclear size for prognosis-related
           malignancy grading
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1

      Simple measurements, carried out in two-dimensional tissue sections, can with the use of stereologic techniques form the basis for the unbiased estimation of three-dimensional nuclear mean size. The method involves point-sampling of nuclear profiles in random histologic sections, and is associated with high efficiency and reproducibility. The requirements for the estimator, including correct sampling at the macroscopic level to counterbalance the existence of heterogeneity in neoplasms, can be satisfied under routine conditions of histopathologic evaluation of human solid cancers, and no special training is necessary. Because of the point-sampling involved, the larger nuclei are sampled preferentially, and the stereologic technique thus provides an estimate of the volume-weighted mean nuclear volume, nuclear v̄V. This is an advantage, when the method is used in the context of solid human cancer, since one of the major characteristics of malignant transformation is an increase in nuclear size. Moreover, it is possible to estimate the nuclear three-dimensional size pleomorphism in two-dimensional tissue sections. This estimator may also be of significant prognostic value in the evaluation of patients with cancer. However, estimates of nuclear v̄V may be sufficient, because they combine data of three-dimensional size with information of pleomorphism of nuclear volume. It is therefore well-suited for use in objective, histopathologic grading of malignancy. From the biological point of view, there seems to be only a weak or even nonexisting correlation between realistic estimates of three-dimensional nuclear mean size and the nuclear DNA content, expressed by the DNA index. Thus, nuclear size may represent a dynamic expression of the disturbed nuclear metabolism of cancer cells, and serve as a sensitive tool for malignancy grading. Unbiased stereologic estimates of nuclear v̄V have confirmed their prognostic value in various human malignant neoplasms, and these findings are now being re-evaluated in prospective studies of patients treated for cancer. The new, objective technology may not only provide prognostic information, but may also be useful in planning treatment and in the clinical follow-up of the patient. It is therefore hoped that stereologic grading of malignancy by simple, reproducible measurements of nuclei, can help replace the traditional, subjective technique for morphologic evaluation of malignancy, and turn histopathologic grading of malignancy into a discipline that aids the clinician in the choice of therapy for individual patients with cancer.

      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 12 Prostate cancer
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1



      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 13 The biology of human melanoma
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1

      Summary Incidence of melanoma, a malignant disease of pigment producing melanocytes, has climbed dramatically in recent years. Ultraviolet radiation probably plays a role in disease pathogenesis. The process of melanoma progression is better understood than that of most human cancers. It is generally accompanied by specific chromosomal alterations and changes in the expression of growth factors, their receptors and other cell surface molecules. While surgery can cure the majority of patients with melanoma, current therapies for metastatic disease are not widely effective. However, since melanoma patients often exhibit a potential weak immune response to the disease, an understanding of melanocyte biology, particularly antigen expression, is leading to new therapeutic strategies. Several promising immunotherapies, including the use of cytokines, anti-melanoma antibodies, and vaccines, are currently under investigation.

      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 14 Aspects of the treatment of B cell malignancies
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1

      B cell malignancies have become a major topic of interest and a focus both for clinical and laboratory research. The fact that they are incurable at present, with a slow evolution and a variable response to different treatment modalities, has suggested a pattern for more common solid tumors. This, coupled with the greater understanding of the role of cytokines in (for example) myeloma, where IL-6 has been shown to be of importance in controlling myeloma cell division, and the discovery not only of the chromosome abnormality of 14;18 translocation in follicular lymphoma, but also the way in which this inhibits apoptosis or programmed cell death in this condition, have made both of these conditions the target for experimental treatment programs. For example, interferon, antibody targeted therapy, and high-dose therapy with either autologous bone marrow or peripheral blood stem cell support are now being explored. The experience gained from high-dose therapy in both myeloma and follicular lymphoma is being translated into new treatment strategies for breast and ovarian cancer.

      PubDate: 2012-12-17T18:13:54Z
       
  • Chapter 15 Principles of cancer chemotherapy
    • Abstract: 1996
      Publication year: 1996
      Source:Advances in Oncobiology, Volume 1

      The modern era of cancer chemotherapy is not yet half a century old, yet the range of drugs available, the multiplicity of their actions, and their ability to cure diseases, which at the time of their introduction were quite incurable, has been astonishing. While combinations of effective drugs have cured children with acute lymphoblastic leukemia, Hodgkin's disease in both children and adults, and testicular tumors in young men, there has (until recently) been a perception that little progress has been made in other solid tumors. It is, however, being admitted that in breast cancer, ovarian cancer, and other solid tumors, the duration and quality of survival may be improved, even if cure is not possible. Knowledge of how drugs act, how their toxicity can be countered, and how tumors become resistant to them, as has been outlined in this chapter, will enable further progress to be made.

      PubDate: 2012-12-17T18:13:54Z
       
 
 
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