Publisher: Elsevier   (Total: 3201 journals)

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Showing 1 - 200 of 3201 Journals sorted alphabetically
Academic Pediatrics     Hybrid Journal   (Followers: 43, SJR: 1.655, CiteScore: 2)
Academic Radiology     Hybrid Journal   (Followers: 27, SJR: 1.015, CiteScore: 2)
Accident Analysis & Prevention     Hybrid Journal   (Followers: 107, SJR: 1.462, CiteScore: 3)
Accounting Forum     Hybrid Journal   (Followers: 30, SJR: 0.932, CiteScore: 2)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 48, SJR: 1.771, CiteScore: 3)
Achievements in the Life Sciences     Open Access   (Followers: 10)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 6)
Acta Astronautica     Hybrid Journal   (Followers: 479, SJR: 0.758, CiteScore: 2)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 2)
Acta Biomaterialia     Hybrid Journal   (Followers: 31, SJR: 1.967, CiteScore: 7)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 3)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 11, SJR: 0.18, CiteScore: 1)
Acta Histochemica     Hybrid Journal   (Followers: 5, SJR: 0.661, CiteScore: 2)
Acta Materialia     Hybrid Journal   (Followers: 354, SJR: 3.263, CiteScore: 6)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.504, CiteScore: 1)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.542, CiteScore: 1)
Acta Oecologica     Hybrid Journal   (Followers: 12, SJR: 0.834, CiteScore: 2)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription  
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 2, SJR: 0.307, CiteScore: 0)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 3, SJR: 1.793, CiteScore: 6)
Acta Psychologica     Hybrid Journal   (Followers: 27, SJR: 1.331, CiteScore: 2)
Acta Sociológica     Open Access   (Followers: 1)
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.052, CiteScore: 2)
Acta Urológica Portuguesa     Open Access   (Followers: 1)
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3, SJR: 0.374, CiteScore: 1)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.344, CiteScore: 1)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 1)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 7, SJR: 0.19, CiteScore: 0)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 3)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 9)
Acute Pain     Full-text available via subscription   (Followers: 15, SJR: 2.671, CiteScore: 5)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.53, CiteScore: 4)
Addictive Behaviors     Hybrid Journal   (Followers: 20, SJR: 1.29, CiteScore: 3)
Addictive Behaviors Reports     Open Access   (Followers: 9, SJR: 0.755, CiteScore: 2)
Additive Manufacturing     Hybrid Journal   (Followers: 18, SJR: 2.611, CiteScore: 8)
Additives for Polymers     Full-text available via subscription   (Followers: 22)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 210, SJR: 4.09, CiteScore: 13)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 14, SJR: 1.167, CiteScore: 4)
Advanced Powder Technology     Hybrid Journal   (Followers: 17, SJR: 0.694, CiteScore: 3)
Advances in Accounting     Hybrid Journal   (Followers: 10, SJR: 0.277, CiteScore: 1)
Advances in Agronomy     Full-text available via subscription   (Followers: 20, SJR: 2.384, CiteScore: 5)
Advances in Anesthesia     Full-text available via subscription   (Followers: 31, SJR: 0.126, CiteScore: 0)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 2)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 12, SJR: 0.992, CiteScore: 1)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 12, SJR: 1.551, CiteScore: 4)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 25, SJR: 2.089, CiteScore: 5)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 0.572, CiteScore: 2)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.61, CiteScore: 7)
Advances in Botanical Research     Full-text available via subscription   (Followers: 2, SJR: 0.686, CiteScore: 2)
Advances in Cancer Research     Full-text available via subscription   (Followers: 36, SJR: 3.043, CiteScore: 6)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 1.453, CiteScore: 2)
Advances in Catalysis     Full-text available via subscription   (Followers: 6, SJR: 1.992, CiteScore: 5)
Advances in Cell Aging and Gerontology     Full-text available via subscription   (Followers: 7)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 15)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 29, SJR: 0.156, CiteScore: 1)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 11, SJR: 0.713, CiteScore: 1)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 11, SJR: 1.316, CiteScore: 2)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 27, SJR: 1.562, CiteScore: 3)
Advances in Clinical Radiology     Full-text available via subscription   (Followers: 3)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 21, SJR: 1.977, CiteScore: 8)
Advances in Computers     Full-text available via subscription   (Followers: 15, SJR: 0.205, CiteScore: 1)
Advances in Cosmetic Surgery     Full-text available via subscription   (Followers: 2)
Advances in Dermatology     Full-text available via subscription   (Followers: 16)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 15)
Advances in Digestive Medicine     Open Access   (Followers: 15)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 8)
Advances in Drug Research     Full-text available via subscription   (Followers: 26)
Advances in Ecological Research     Full-text available via subscription   (Followers: 46, SJR: 2.524, CiteScore: 4)
Advances in Engineering Software     Hybrid Journal   (Followers: 31, SJR: 1.159, CiteScore: 4)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 10)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 55, SJR: 5.39, CiteScore: 8)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 2)
Advances in Family Practice Nursing     Full-text available via subscription   (Followers: 1)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 9)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 72, SJR: 0.591, CiteScore: 2)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 19)
Advances in Genetics     Full-text available via subscription   (Followers: 20, SJR: 1.354, CiteScore: 4)
Advances in Genome Biology     Full-text available via subscription   (Followers: 12, SJR: 12.74, CiteScore: 13)
Advances in Geophysics     Full-text available via subscription   (Followers: 9, SJR: 1.193, CiteScore: 3)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 26, SJR: 0.368, CiteScore: 1)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 11, SJR: 0.749, CiteScore: 3)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 26)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 5, SJR: 0.193, CiteScore: 0)
Advances in Immunology     Full-text available via subscription   (Followers: 42, SJR: 4.433, CiteScore: 6)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 12, SJR: 1.163, CiteScore: 2)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 2, SJR: 1.938, CiteScore: 3)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6, SJR: 0.176, CiteScore: 0)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 3)
Advances in Life Course Research     Hybrid Journal   (Followers: 11, SJR: 0.682, CiteScore: 2)
Advances in Lipobiology     Full-text available via subscription   (Followers: 2)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Marine Biology     Full-text available via subscription   (Followers: 22, SJR: 0.88, CiteScore: 2)
Advances in Mathematics     Full-text available via subscription   (Followers: 17, SJR: 3.027, CiteScore: 2)
Advances in Medical Sciences     Hybrid Journal   (Followers: 10, SJR: 0.694, CiteScore: 2)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 5, SJR: 1.158, CiteScore: 3)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 28)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 8)
Advances in Molecular Pathology     Hybrid Journal   (Followers: 2)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.182, CiteScore: 0)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 4)
Advances in Oncobiology     Full-text available via subscription   (Followers: 3)
Advances in Ophthalmology and Optometry     Full-text available via subscription   (Followers: 1)
Advances in Organ Biology     Full-text available via subscription   (Followers: 3)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 19, SJR: 1.875, CiteScore: 4)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.174, CiteScore: 0)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 1.579, CiteScore: 4)
Advances in Pediatrics     Full-text available via subscription   (Followers: 27, SJR: 0.461, CiteScore: 1)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 21)
Advances in Pharmacology     Full-text available via subscription   (Followers: 18, SJR: 1.536, CiteScore: 3)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 11, SJR: 0.574, CiteScore: 1)
Advances in Phytomedicine     Full-text available via subscription   (Followers: 1)
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.109, CiteScore: 1)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 10)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 7)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 19)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 21, SJR: 0.791, CiteScore: 2)
Advances in Psychology     Full-text available via subscription   (Followers: 74)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 7, SJR: 0.371, CiteScore: 1)
Advances in Radiation Oncology     Open Access   (Followers: 3, SJR: 0.263, CiteScore: 1)
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.101, CiteScore: 0)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 7)
Advances in Space Research     Full-text available via subscription   (Followers: 452, SJR: 0.569, CiteScore: 2)
Advances in Structural Biology     Full-text available via subscription   (Followers: 6)
Advances in Surgery     Full-text available via subscription   (Followers: 12, SJR: 0.555, CiteScore: 2)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 37, SJR: 2.208, CiteScore: 4)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 21)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 15)
Advances in Virus Research     Full-text available via subscription   (Followers: 6, SJR: 2.262, CiteScore: 5)
Advances in Water Resources     Hybrid Journal   (Followers: 59, SJR: 1.551, CiteScore: 3)
Aeolian Research     Hybrid Journal   (Followers: 6, SJR: 1.117, CiteScore: 3)
Aerospace Science and Technology     Hybrid Journal   (Followers: 420, SJR: 0.796, CiteScore: 3)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.42, CiteScore: 2)
African J. of Emergency Medicine     Open Access   (Followers: 6, SJR: 0.296, CiteScore: 0)
Ageing Research Reviews     Hybrid Journal   (Followers: 13, SJR: 3.671, CiteScore: 9)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 494, SJR: 1.238, CiteScore: 3)
Agri Gene     Hybrid Journal   (Followers: 1, SJR: 0.13, CiteScore: 0)
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 18, SJR: 1.818, CiteScore: 5)
Agricultural Systems     Hybrid Journal   (Followers: 32, SJR: 1.156, CiteScore: 4)
Agricultural Water Management     Hybrid Journal   (Followers: 47, SJR: 1.272, CiteScore: 3)
Agriculture and Agricultural Science Procedia     Open Access   (Followers: 4)
Agriculture and Natural Resources     Open Access   (Followers: 3)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 60, SJR: 1.747, CiteScore: 4)
Ain Shams Engineering J.     Open Access   (Followers: 7, SJR: 0.589, CiteScore: 3)
Air Medical J.     Hybrid Journal   (Followers: 8, SJR: 0.26, CiteScore: 0)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.19, CiteScore: 0)
Alcohol     Hybrid Journal   (Followers: 12, SJR: 1.153, CiteScore: 3)
Alcoholism and Drug Addiction     Open Access   (Followers: 12)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 2)
Alexandria Engineering J.     Open Access   (Followers: 3, SJR: 0.604, CiteScore: 3)
Alexandria J. of Medicine     Open Access   (Followers: 1, SJR: 0.191, CiteScore: 1)
Algal Research     Partially Free   (Followers: 10, SJR: 1.142, CiteScore: 4)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.504, CiteScore: 1)
Allergology Intl.     Open Access   (Followers: 5, SJR: 1.148, CiteScore: 2)
Alpha Omegan     Full-text available via subscription   (SJR: 3.521, CiteScore: 6)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 12, SJR: 0.201, CiteScore: 1)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 60, SJR: 4.66, CiteScore: 10)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 5)
American Heart J.     Hybrid Journal   (Followers: 62, SJR: 3.267, CiteScore: 4)
American J. of Cardiology     Hybrid Journal   (Followers: 71, SJR: 1.93, CiteScore: 3)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 52, SJR: 0.604, CiteScore: 1)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 13)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 18, SJR: 1.524, CiteScore: 3)
American J. of Human Genetics     Hybrid Journal   (Followers: 45, SJR: 7.45, CiteScore: 8)
American J. of Infection Control     Hybrid Journal   (Followers: 36, SJR: 1.062, CiteScore: 2)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 42, SJR: 2.973, CiteScore: 4)
American J. of Medicine     Hybrid Journal   (Followers: 50)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3, SJR: 1.967, CiteScore: 2)
American J. of Obstetrics & Gynecology MFM     Hybrid Journal   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 291, SJR: 2.7, CiteScore: 4)
American J. of Ophthalmology     Hybrid Journal   (Followers: 71, SJR: 3.184, CiteScore: 4)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 6, SJR: 0.265, CiteScore: 0)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.289, CiteScore: 1)
American J. of Otolaryngology     Hybrid Journal   (Followers: 25, SJR: 0.59, CiteScore: 1)
American J. of Pathology     Hybrid Journal   (Followers: 33, SJR: 2.139, CiteScore: 4)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 30, SJR: 2.164, CiteScore: 4)
American J. of Surgery     Hybrid Journal   (Followers: 41, SJR: 1.141, CiteScore: 2)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.767, CiteScore: 1)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 8)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.144, CiteScore: 3)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 72, SJR: 0.138, CiteScore: 0)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 28, SJR: 0.411, CiteScore: 1)
Anales de Cirugia Vascular     Full-text available via subscription   (Followers: 1)
Anales de Pediatría     Full-text available via subscription   (Followers: 3, SJR: 0.277, CiteScore: 0)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription  
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 7, SJR: 4.849, CiteScore: 10)
Analytica Chimica Acta     Hybrid Journal   (Followers: 44, SJR: 1.512, CiteScore: 5)
Analytica Chimica Acta : X     Open Access  
Analytical Biochemistry     Hybrid Journal   (Followers: 239, SJR: 0.633, CiteScore: 2)
Analytical Chemistry Research     Open Access   (Followers: 14, SJR: 0.411, CiteScore: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 14)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 2)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 25, SJR: 0.683, CiteScore: 2)
Angiología     Full-text available via subscription   (SJR: 0.121, CiteScore: 0)
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1, SJR: 0.111, CiteScore: 0)

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Similar Journals
Journal Cover
Advances in Inorganic Chemistry
Journal Prestige (SJR): 1.163
Citation Impact (citeScore): 2
Number of Followers: 12  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0898-8838
Published by Elsevier Homepage  [3201 journals]
  • Coordination compounds with siloxane/silane-containing ligands capable of
           self-assembly at nano/micro scale in solid state and in solution
    • Abstract: Publication date: Available online 13 May 2020Source: Advances in Inorganic ChemistryAuthor(s): Mirela-Fernanda Zaltariov, Maria Cazacu
       
  • Mussel inspired self-healing materials: Coordination chemistry of
           polyphenols
    • Abstract: Publication date: Available online 10 May 2020Source: Advances in Inorganic ChemistryAuthor(s): Henrik Birkedal, Yaqing Chen
       
  • Selected polyazole based coordination polymers displaying functional
           properties
    • Abstract: Publication date: Available online 7 May 2020Source: Advances in Inorganic ChemistryAuthor(s): Yann Garcia
       
  • Nano-architectonics for coordination assemblies at interfacial media
    • Abstract: Publication date: Available online 4 May 2020Source: Advances in Inorganic ChemistryAuthor(s): Katsuhiko Ariga
       
  • Nanoscale coordination compounds
    • Abstract: Publication date: Available online 29 April 2020Source: Advances in Inorganic ChemistryAuthor(s): Younes Hanifehpour, Babak Mirtamizdoust, Sang Woo Joo
       
  • Nanoscale coordination polymers for medicine and sensors
    • Abstract: Publication date: Available online 29 April 2020Source: Advances in Inorganic ChemistryAuthor(s): Rubén Solórzano, Salvio Suárez-García, Fernando Novio, Julia Lorenzo, Ramon Alibés, Félix Busqué, Daniel Ruiz-Molina
       
  • Nanoscale coordination polymers: Preparation, function and application
    • Abstract: Publication date: Available online 25 April 2020Source: Advances in Inorganic ChemistryAuthor(s): Ali Morsali, Lida Hashemi
       
  • The role of defects in the properties of functional coordination polymers
    • Abstract: Publication date: Available online 25 April 2020Source: Advances in Inorganic ChemistryAuthor(s): Celia Castillo-Blas, Carmen Montoro, Ana E. Platero-Prats, Pablo Ares, Pilar Amo-Ochoa, Javier Conesa, Félix Zamora
       
  • CXCR4-targeted metal complexes for molecular imaging
    • Abstract: Publication date: Available online 29 January 2020Source: Advances in Inorganic ChemistryAuthor(s): Isaline Renard, Stephen J. ArchibaldAbstractMetal ions have been used in multiple roles for the noninvasive molecular imaging of protein expression levels on the surface of cells. They can be employed to enhance binding of the complex to the protein through the formation of coordinate bonds with donor atoms on amino acid side chains. Metal ions can also, with the selection of appropriate isotopes, emit gamma rays or positrons (which annihilate to give gamma rays) that can be detected outside the body using the relevant tomographic scanners to form an image of molecular localization. Positron emission tomography is the preferred imaging modality.The chemokine receptor CXCR4 has been implicated in multiple disease states and immune system disorders but most relevant, for molecular imaging, is the correlation of high expression levels with poor prognosis in a number of cancers. CXCR4 has therefore been a target for small molecule drugs and for imaging agents. There has been considerable development work carried out over the past 20 years with particular success in the development of metal complexes that bind to CXCR4 with high affinity.The design of CXCR4 binding probes includes both peptidic and azamacrocyclic metal complexes, with the use of transition metals for binding a particularly successful avenue of research. The main radioisotopes that have been used are copper-64 and gallium-68 with some compounds translated into preclinical and clinical imaging over the past few years.
       
  • 150 years of the periodic table: New medicines and diagnostic agents
    • Abstract: Publication date: Available online 14 January 2020Source: Advances in Inorganic ChemistryAuthor(s): Cinzia Imberti, Peter J. SadlerAbstract150 years after Mendeleev created his periodic table of 63 elements, now is the time to explore its impact on our understanding of life itself and the discovery of new medicines and diagnostic agents. We illustrate that currently 76 elements have compounds either approved for clinical use or in clinical trials for therapy or diagnosis. Modern analytical techniques and the methods of modern cell and molecular biology, including proteomics and genomics, can now be used to guide the design and application of both essential and non-essential elements in therapy and diagnosis, including stable and radioactive elements. In particular, there is potential for the target sites and mechanisms of action of metallodrugs to be identified. However, the speciation of the elements in biological environments presents enormous challenges. The biological activity of metal coordination complexes is highly dependent on the metal plus its ligands, and also on both thermodynamics (strengths of metal-ligand bonds), and kinetics (timescales of the making and breaking of coordination bonds), as well as metal- and ligand-based redox processes. Notably, biological systems/metabolic pathways are inherently dynamic. Using examples from our recent research, we illustrate how ligands exert fine control over the chemical reactivity and biological activity of metal complexes. Elucidation of the spatial and temporal coordination chemistry of metals in biological systems is likely to add exciting new dimensions to the periodic table.
       
  • From the hypothesis-driven development of organometallic anticancer drugs
           to new methods in mode of action studies
    • Abstract: Publication date: Available online 9 December 2019Source: Advances in Inorganic ChemistryAuthor(s): Muhammad Hanif, Christian G. HartingerAbstractMore often than not, cancer patients are treated with chemotherapeutic cocktails that contain Pt-based drugs. Current research in the field of anticancer organometallics focuses on compounds with modes of action usually different from these drugs. Our research aims to design novel anticancer agents often based on bioactive ligands coordinated to metal centers, which results in synergistic effects and properties neither of the components on their own would have. In this chapter, we summarize the development of selected compound classes studied and describe how we employ a systematic approach when it comes to compound design and informed decision making in anticancer metallodrug research.
       
  • Anti-cancer gold, platinum and iridium compounds with porphyrin and/or
           N-heterocyclic carbene ligand(s)
    • Abstract: Publication date: Available online 23 November 2019Source: Advances in Inorganic ChemistryAuthor(s): Ka-Chung Tong, Di Hu, Pui-Ki Wan, Chun-Nam Lok, Chi-Ming CheAbstractMetal complexes of d8 and d10 metal ions having planar coordination geometry provide diverse structural scaffolds for non-covalent and covalent interactions with bio-molecular targets. These complexes can be harnessed to design new diagnostics and therapeutics for the treatment of cancer. We have employed ligands with N donor and/or C donor atom(s), such as pincer cyclometalated (C∧N∧N) moieties, porphyrins and N-heterocyclic carbenes (NHCs), to prepare cationic Au(III), Au(I), Pt(II), Pd(II) and Ir(III) complexes, all of which display good stability under physiological conditions. Apart from the strong M–NHC bond(s) that lend the metal–NHC complexes a favorable stability against demetalation in solution, the coordination of metal ions with NHC ligand(s) can give rise to strongly luminescent behavior of the metal complexes due to the suppression of excited state structural distortion. The d8- and d10-metal complexes described herein exhibit potent cytotoxicity in cancer cells in culture as well as anti-tumor activity in mouse models of cancer. Chemical formulation strategies, such as bio-conjugation and encapsulation, can be used to deliver the cytotoxic, anti-cancer metal complexes to tumors with lower toxic side effects. The molecular targets of some of these metal complexes have been identified using clickable photo-affinity probes and cellular thermal-shift proteomics, revealing the engagement of multiple targets. These results account for the effective anti-cancer properties with a less likelihood of developing drug resistance.
       
  • Rational design of anticancer platinum(IV) prodrugs
    • Abstract: Publication date: Available online 22 November 2019Source: Advances in Inorganic ChemistryAuthor(s): Shuren Zhang, Xiaoyong Wang, Zijian GuoAbstractPlatinum-based anticancer drugs such as cisplatin play a crucial role in the treatment of various malignant tumors; however, their therapeutic effects are severely hampered by drug resistance and systemic toxicities. Recently, octahedral PtIV prodrugs have attracted much attention as the next generation of Pt-based anticancer drug candidates. PtIV complexes can be easily functionalized with some biologically innocent or active ligands to tune their pharmacological properties for overcoming the drawbacks of traditional PtII-based drugs. This review presents a comprehensive overview on the PtIV anticancer complexes that have been reported in the past decades from drug design perspectives. These complexes are classified into three categories based on their different design purposes, including to conquer cisplatin resistance, to ameliorate cisplatin toxicities, and to target tumor microenvironment. Representative examples of each type are discussed in terms of design principle, chemical structure, cytotoxicity, mechanism of action, and possible limitations in medical application. In the end, future opportunities and challenges in this field are tentatively proposed. The information and views presented in this review are suggested to help generating new ideas and strategies to design and develop novel Pt-based anticancer drugs with high efficacy and low toxicity.
       
  • Bismuth drugs as antimicrobial agents
    • Abstract: Publication date: Available online 22 November 2019Source: Advances in Inorganic ChemistryAuthor(s): Runming Wang, Hongyan Li, Tiffany Ka-Yan Ip, Hongzhe SunAbstractBismuth-based agents have been widely used in medicine, particularly as the active components for the treatment of Helicobacter pylori-associated gastrointestinal ailments. The selective toxicity of bismuth toward Helicobacter pylori stems from the intrinsic chemical and biological properties of bismuth. The molecular targets of bismuth agents and their antimicrobial mechanisms of action are reviewed. Beyond anti-Helicobacter pylori actions, novel bismuth-based agents with broad antimicrobial activities against both Gram-positive and Gram-negative bacterial pathogens are highlighted. Intriguingly, bismuth-based combination therapy could effectively treat infections caused by antibiotic resistant superbugs. This chapter strives to offer an account of state-of-the-art research progress on antibacterial mechanisms of action of bismuth and explore the frontiers of up-to-date potential medicinal applications of bismuth-based agents with reference to recent developments in the literature.
       
  • The eyes have it: Using X-ray crystallography to determine the binding
           modes of medically relevant ruthenium/DNA complexes
    • Abstract: Publication date: Available online 20 November 2019Source: Advances in Inorganic ChemistryAuthor(s): Kane Thomas McQuaid, Christine Janet CardinAbstractRuthenium polypyridyl complexes have been intensively studied in many laboratories around the world for their potential applications in chemotherapy, including photodynamic therapy, and as useful DNA probes and sensors in cells. This chapter discusses the ways in which X-ray crystallography can contribute to our understanding of these applications at the molecular level. The design of useful compounds relies on assumptions about the shape and possible flexibility of the molecular target, and an appreciation of how and why a small change in the molecular design can have a major impact on the effectiveness of the compound.
       
  • Medicinal inorganic chemistry: New perspectives and targets for the
           periodic table
    • Abstract: Publication date: Available online 20 November 2019Source: Advances in Inorganic ChemistryAuthor(s): Nicholas P. FarrellAbstractPlatinum-based anticancer drugs have had an unprecedented effect on cancer chemotherapy since the FDA approval of cisplatin in 1978. In this chapter I summarize recent new directions and results from my laboratory and our collaborators on polynuclear platinum complexes (PPCs), a discrete class of anticancer drugs. First, the biological activity of highly-charged substitution-inert complexes (SI-PPCs) will be reviewed with emphasis on their unique mode of DNA recognition through the phosphate clamp—distinct from canonical DNA-ligand binding through intercalation and minor-groove binding. Besides the molecular details of the DNA/RNA recognition, the PPCs are distinguished from intercalators and minor-groove binders by their very high efficiency in condensing DNA, even in cells. Second, evidence for membrane interactions, and especially those of glycosaminoglycans (GAGs), will be summarized leading to the clear confirmation that the PPC class must be considered an intrinsically dual-function agent, whose biological activity must be seen as the sum of its target interactions, with significant implications for approaches to personalized medicine for platinums. Especially, a systematic molecular approach to inhibition of tumor angiogenesis and invasion is suggested by consideration of GAGs as target for platinum agents. Finally, the role of metal ions in the function of the extracellular matrix will be discussed and molecular approaches to understanding of endogenous metal ion affinity will be illustrated using Mn2 + as an example.
       
  • Antimony and bismuth as antimicrobial agents
    • Abstract: Publication date: Available online 20 November 2019Source: Advances in Inorganic ChemistryAuthor(s): Rebekah N. Duffin, Melissa V. Werrett, Philip C. AndrewsAbstractThere is an emerging interest in the application of metal complexes in the treatment of microbial infections and colonization. Their unique modes of action and the difficulty that microbes face in evolving mechanisms for resistance toward metal complexes, makes them attractive. Metal complexes offer a way to incorporate a diverse range of ligands and therefore easily tune physico-chemical properties, which in turn can affect the overall behavior of the complex in a biological system.For more than a decade, we have synthesized and characterized a range of bismuth and antimony complexes in the + III and + V oxidation states and evaluated their efficacy toward the treatment of Leishmania or bacteria, including but not limited to: Helicobacter pylori, methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus and Escherichia coli. In many cases these novel complexes outperform the current medicinal compounds employed. There is still work to be done to understand the relationship between the chemical structure of metal complexes and their corresponding antimicrobial activity. We have compiled recent results in the area of metal complexes against microbes, to uncover some of the trends related to antimicrobial activity.
       
  • Metal N-heterocyclic carbene complexes in medicinal chemistry
    • Abstract: Publication date: Available online 15 November 2019Source: Advances in Inorganic ChemistryAuthor(s): Ingo OttAbstractBased on their strong σ-donor properties N-heterocyclic carbene (NHC) ligands can form stable complexes with many transition metals. Numerous applications of metal NHC complexes have been developed in the field of chemical catalysis. The option to generate very stable complexes as well as the convenient access to a high number of structurally diverse NHC ligands have made them also attractive target compounds in inorganic medicinal chemistry. A fast increasing number of reports demonstrates that metal NHC complexes provide an excellent scaffold for metallodrug design and many examples have been studied pharmacologically in great detail. This chapter focuses on metal NHC complexes containing the selected metals ruthenium, rhodium, silver, iridium and gold.
       
  • Interaction of metal complexes with G-quadruplex DNA
    • Abstract: Publication date: Available online 15 November 2019Source: Advances in Inorganic ChemistryAuthor(s): Ramon VilarAbstractBesides its canonical double helix, DNA can fold into a range of different topologies one of which is the guanine-quadruplexes (G4). Over the past 20 years, there has been increasing experimental evidence linking the cellular formation of G4 DNA structures with several biological functions. Therefore, there has been great interest in developing small molecules that can bind selectively to G4s stabilizing them, and in doing so trigger a number of biological effects. Hence, these DNA binders can be useful probes to help unveil the biology of G4s as well as new potential drug candidates. This chapter reviews our group's work over the past few years aimed at developing metal complexes as G4 binders.
       
  • Pharmacophore conjugation strategy for multi-targeting metal-based
           anticancer complexes
    • Abstract: Publication date: Available online 15 November 2019Source: Advances in Inorganic ChemistryAuthor(s): Yao Zhao, Yan Kang, Fengmin Xu, Wei Zheng, Qun Luo, Yanyan Zhang, Feifei Jia, Fuyi WangAbstractMetal-based anticancer drugs play a very important role in clinical therapy. Classical platinum anticancer drugs bind to DNA, causing various kind of DNA damage so as to induce the cancer apoptosis. However, severe side effects and inherited or acquired resistance limit their application. As cancers are multiple factor induced diseases, drugs that act at multiple targets may exert higher efficacy and lower resistance. In recent years, multi-targeting anticancer drugs attract broad attention in drug development. Pharmacophore conjugation strategy is one of the most important way to design and obtain multi-targeting drugs. Its application in developing novel metal-based multi-targeting anticancer agents will be discussed in detail.
       
  • Organelle-targeting metal anticancer agents
    • Abstract: Publication date: Available online 15 November 2019Source: Advances in Inorganic ChemistryAuthor(s): Lina Xie, Ruilin Guan, Thomas W. Rees, Hui ChaoAbstractOrganelles, including the nucleus, mitochondria, lysosomes, the endoplasmic reticulum (ER), and the Golgi apparatus are essential for the function of a cell. Organelle-targeting cancer treatment can aid our insight into the mechanism of action of therapeutic agents and prevent potential off-target side effects toward normal tissue. The excellent optical properties of luminescent metal complexes such as long-lived phosphorescence, high photostability and large Stokes shifts, also allows their use as theranostic agents and the exploration of how organelles function in cancerous cells. This review focuses on the general design strategy of organelle-targeting metal complexes and their application in organelle-targeting cancer treatment.
       
  • Design and applications of catalytic metallodrugs containing the ATCUN
           motif
    • Abstract: Publication date: Available online 8 November 2019Source: Advances in Inorganic ChemistryAuthor(s): Zhen Yu, James A. CowanAbstractThe aim of this chapter is to provide a brief account of the discovery and application of catalytic metallodrugs, and specifically those cases that include a catalytic metal-ATCUN motif. The concepts and design strategies for catalytic metallodrugs are illustrated through recent examples that target G-quadruplex telomeric DNA, H2-antigen, Flavivirus NS2B/NS3 proteases, and lipid bilayers of bacteria. The distinct advantages of the tripeptide ATCUN metal chelate are described and well illustrated through these examples, and longstanding challenges in metallodrug design and use are discussed, including the potential for metal toxicity, applications as “prodrugs,” and metal lability.
       
  • Series Page
    • Abstract: Publication date: 2019Source: Advances in Inorganic Chemistry, Volume 74Author(s):
       
  • Mechanisms of water oxidation using ruthenium, cobalt, copper, and iron
           molecular catalysts
    • Abstract: Publication date: Available online 14 June 2019Source: Advances in Inorganic ChemistryAuthor(s): Alexander Rene Parent, Takashi Nakazono, Yuta Tsubonouchi, Natsuki Taira, Ken SakaiAbstractThis review focuses on the studies of molecular water oxidation catalysts based on ruthenium, cobalt, copper, and iron, with emphasis given to the works undertaken thus far by the authors' group in the last decade. A particular emphasis is given on our mechanistic studies of water oxidation, and the involvement of the chemical oxidants employed in the catalytic mechanism.
       
  • Artificial photosynthesis systems for catalytic water oxidation
    • Abstract: Publication date: Available online 29 May 2019Source: Advances in Inorganic ChemistryAuthor(s): Sheng Ye, Chunmei Ding, Can LiAbstractThe consumption of fossil fuel energy and the resulting environmental pollution have incentivized scientists to attempt to develop renewable, reliable and continuously available energy sources. Solar water splitting to produce hydrogen is one of the effective ways to solve the energy and environmental problems. Water oxidation (2H2O → 4H+ + 4e− + O2), as one half of the water-splitting reaction, is the primary reaction of both natural and artificial photosynthesis, thus the development of highly active and robust water oxidation catalysts (WOCs) is extremely important for constructing a sustainable artificial photosynthesis system for solar energy conversion. Molecular catalysts and inorganic nanoparticles, as representatives of homogeneous and heterogeneous catalysts, have their respective advantages and have been widely studied. Moreover, hybrid systems combining the molecular catalysts and inorganic nanoparticles, exhibit unique advantages for water oxidation and bridge the gap between homogeneous catalysis and heterogeneous catalysis. Despite significant efforts made so far, a practically viable catalytic system with sufficient efficiency, stability and low cost is yet to be demonstrated. The present topic mainly focuses on the recent advances on different types of WOCs that are generally screened out by several evaluating approaches, such as chemical water oxidation, electrocatalytic water oxidation and photo(electro)catalytic water oxidation. Furthermore, understanding the water oxidation mechanism, including elucidation of the role of active intermediates during the water oxidation process, is helpful to develop more efficient WOCs.
       
  • Insights into artificial water oxidation—A computational perspective
    • Abstract: Publication date: Available online 11 May 2019Source: Advances in Inorganic ChemistryAuthor(s): Mauro Schilling, Sandra LuberAbstractNumerous researchers around the globe are focusing their efforts toward the development of renewable energy sources. Among them are devices that harvest sun light and use it to split water into molecular hydrogen and oxygen. Thereby water oxidation is believed to be one of the bottlenecks that needs to be overcome through the development of appropriate catalysts. An in-depth understanding of the fundamental properties of those catalysts is crucial in order to improve them further or to design novel catalysts with high catalytic activity and stability. Theoretical studies offer a great opportunity, to elucidate the structure and dynamics of the catalyst, the catalytic mechanism, and the properties of potential intermediates. In this chapter, we describe our recent efforts for advanced modeling of catalysis and how the combined effort of experimental and computational work can lead to a better understanding of the catalysts at hand and development of new catalysts. Thereby we focus on two families of catalysts studied by our group. First we introduce tetranuclear Co(II)-based water oxidation catalysts featuring a cubane core as found in the oxygen evolving complex of nature's photosystem II. Afterward, we discuss selected mononuclear Ru(II)-based water oxidation catalysts.
       
  • Water oxidation by manganese oxides
    • Abstract: Publication date: Available online 10 May 2019Source: Advances in Inorganic ChemistryAuthor(s): Mina Tavakolian, Payam Salimi, Zahra Zand, Mohammad Mahdi NajafpourAbstractSustainable energies are usually intermittent and if solar energy is to become an energy source in future, energy-storage systems are necessary. A reasonable solution to store solar energy is artificial photosynthesis with energy stored in chemical bonds such as molecular hydrogen. Among different strategies, water splitting toward hydrogen and oxygen is very promising. This article provides a short review of the current status of manganese compounds as water-oxidizing catalysts in artificial photosynthesis. Generalization and inductive reasoning have been criticized, but at least many manganese complexes and salts convert to Mn oxide during water oxidation. Thus, we focused on Mn oxides and discuss the sophisticated design strategies for manganese oxides as water-oxidizing catalysts. Since an Mn oxide-cluster acts as the biological site for water oxidation, Mn oxides are counted as structural and functional models for the water-oxidizing cluster in photosystem II.
       
  • Plausible roles of carbonate in catalytic water oxidation
    • Abstract: Publication date: Available online 28 April 2019Source: Advances in Inorganic ChemistryAuthor(s): Amir Mizrahi, Dan MeyersteinAbstractBicarbonate/carbonate are efficient co-catalysts in a variety of water oxidation processes. Their role in these processes is due to one or more of the following: the redox potential of the couple CO3⋅−/CO32– is considerably lower than that of OH/H2O or that of OH/OH−. The CO3⋅− thus formed is transformed into HCO4−/H2O2. The latter are easily oxidized to form O2. Furthermore CO32– as a ligand stabilizes transition metal complexes at high-oxidation states that are essential intermediates in the catalytic processes. Finally, the carbonate facilitates proton transfer near the anode that is often an essential step.
       
  • Recent advances in electrodes modified with ruthenium complexes for
           electrochemical and photoelectrochemical water oxidation
    • Abstract: Publication date: Available online 25 April 2019Source: Advances in Inorganic ChemistryAuthor(s): Tong Yang, Hong Yin, Li-Hui Gao, Ke-Zhi Wang, Dongpeng YanAbstractThere still remain several challenges regarding successful water spitting in artificial photosynthesis. The approach of using catalysts/photosensitizers immobilized on electrode surfaces toward water oxidation into dioxygen has attracted considerable interest recently. This can be attributed partly to their significantly improved durability and convenience for practical applications, as compared to homogeneous molecular systems. Notable progress in this context has been achieved using ruthenium complexes. This review highlights recent progress regarding electrodes modified with such complexes as the catalysts/photochromophores toward electrochemical and photoelectrochemical (PEC) water oxidation. Representative examples of these ruthenium complexes are described; and the various properties delineated according to their film-forming methods of covalent self-assembly, electrografting or/and click chemistry, electropolymerization, π-π stacking/hydrophobic interactions, electrostatic self-assembly, solvothermal growth/post-synthetic exchange and drop casting. Suggestions for future opportunities and challenges for heterogeneous PEC catalytic oxidation of water into dioxygen are presented.
       
  • Electrocatalytic materials design for oxygen evolution reaction
    • Abstract: Publication date: Available online 25 April 2019Source: Advances in Inorganic ChemistryAuthor(s): Josué M. Gonçalves, Tiago A. Matias, Kalil C.F. Toledo, Koiti ArakiAbstractProduction of clean energy in a sustainable way is of utmost importance in modern society, but reactions such as the oxygen evolution reaction, well-known for its sluggishness and energy requirements, play a key role in fuel cells technology and conversion of solar energy into fuels. Thus, efficient water oxidation catalysts (WOCs) based on abundant elements are attracting lots of scientific and technological interest, where active site engineering and a conductivity optimization approach are being used in the quest for the “ideal catalyst.” The recent advancements in the design of molecular and oxide/hydroxide WOCs, as well as hybrid derivatives and composite materials are the scope of this chapter. The choices and tuning of relevant structural and electronic parameters are fundamental for molecular and hybrid materials, and the isomorphic substitution in, and doping of bimetallic and trimetallic oxide/hydroxides, are paving the way to high performance WOCs.
       
  • Water oxidation catalysis with well-defined molecular iron complexes
    • Abstract: Publication date: Available online 23 April 2019Source: Advances in Inorganic ChemistryAuthor(s): Carla Casadevall, Alberto Bucci, Miquel Costas, Julio Lloret-FillolAbstractIron is an exceptional chemical element due to its low cost, abundance and biocompatibility, but also in terms of the accessible redox states. As a natural evolution to the rich oxidative chemistry that can mediate water oxidation catalysts, during the last decade, iron coordination complexes have emerged as a promising platform for investigation. In this chapter the main progress on the design of well-defined water oxidation (WO) catalysts based on iron is covered, as well as evidence for the WO proposed mechanisms. Ligand design is critical for the rationalization of the catalytic activity and therefore the different architectures are used as the crucial pillar structure of the chapter. Over the different sections, we present detailed characterization of reaction intermediates and provide insights into our understanding of the O–O bond formation event. In this regard, the most illustrative studies are those based on chemical oxidants. Electrocatalysis and electrode functionalization studies, although still very preliminary, indicate that possibilities toward applications could materialize. The few studies of the challenging light-driven water oxidation are also covered. Finally, multinuclear iron complexes are of particular interest, since they provide a clear route for the development of electrocatalysts. In addition, a discussion of metal organic frameworks (MOFs) and polyoxometalates (POMs) is also included in this chapter.
       
 
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