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Publisher: Elsevier   (Total: 3030 journals)

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Showing 1 - 200 of 3030 Journals sorted alphabetically
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 20, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 16, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 79, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 22, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 27, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 4)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 5, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 303, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 3)
Acta Biomaterialia     Hybrid Journal   (Followers: 25, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription  
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 196, SJR: 3.683, h-index: 202)
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Acta Oecologica     Hybrid Journal   (Followers: 9, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription   (Followers: 1)
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Acta Pharmaceutica Sinica B     Open Access   (Followers: 2)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 21, SJR: 1.365, h-index: 73)
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Acta Tropica     Hybrid Journal   (Followers: 5, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
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Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 5, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 4, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 4)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 5)
Additive Manufacturing     Hybrid Journal   (Followers: 7, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 20)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 120, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 16, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 8, SJR: 0.299, h-index: 15)
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Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
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Advances in Cancer Research     Full-text available via subscription   (Followers: 26, SJR: 2.215, h-index: 78)
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Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
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Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 8, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 16, SJR: 0.223, h-index: 22)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 11)
Advances in Digestive Medicine     Open Access   (Followers: 4)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Ecological Research     Full-text available via subscription   (Followers: 39, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 25, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 7)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 38, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 3)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 41, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 14)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
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Advances in Heat Transfer     Full-text available via subscription   (Followers: 18, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.497, h-index: 31)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 22)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 33, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 3, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 4)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 4)
Advances in Life Course Research     Hybrid Journal   (Followers: 7, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 8)
Advances in Marine Biology     Full-text available via subscription   (Followers: 16, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 5, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 21)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 10)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 6, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 3)
Advances in Oncobiology     Full-text available via subscription   (Followers: 3)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 20, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 14)
Advances in Pharmacology     Full-text available via subscription   (Followers: 13, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 7, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 4)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 17, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 56)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 1, SJR: 0.1, h-index: 2)
Advances in Space Research     Full-text available via subscription   (Followers: 332, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 7)
Advances in Surgery     Full-text available via subscription   (Followers: 6, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 28, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 14)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 12)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 42, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 5, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 304, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 4, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 7, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 390, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 29, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 36, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access  
Agriculture and Natural Resources     Open Access   (Followers: 1)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 48, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 3, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 9, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 5)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access  
Algal Research     Partially Free   (Followers: 7, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 5, SJR: 0.776, h-index: 35)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 6, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 45, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 5)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 3)
American Heart J.     Hybrid Journal   (Followers: 45, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 47, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 34, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 6, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 32, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 25, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 31, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 48, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 174, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 51, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 2)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 22, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 23, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 21, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 32, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 13, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 5)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 52, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 3)
Anales de Cirugia Vascular     Full-text available via subscription  
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Analytic Methods in Accident Research     Hybrid Journal   (Followers: 2, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 38, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 154, SJR: 0.725, h-index: 154)
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Angiologia e Cirurgia Vascular     Open Access  
Animal Behaviour     Hybrid Journal   (Followers: 143, SJR: 1.907, h-index: 126)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 5, SJR: 1.151, h-index: 83)
Animal Reproduction Science     Hybrid Journal   (Followers: 5, SJR: 0.711, h-index: 78)
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Journal Cover Advances in Inorganic Chemistry
  [SJR: 1.132]   [H-I: 42]   [9 followers]  Follow
    
   Full-text available via subscription Subscription journal  (Not entitled to full-text)
   ISSN (Print) 0898-8838
   Published by Elsevier Homepage  [3030 journals]
  • Series Page
    • Abstract: Publication date: 2017
      Source:Advances in Inorganic Chemistry, Volume 69


      PubDate: 2017-02-24T06:31:50Z
       
  • Errata: Catalytic Hydrogenation of Carbon Dioxide to Formic Acid
    • Abstract: Publication date: 2017
      Source:Advances in Inorganic Chemistry, Volume 69


      PubDate: 2017-02-24T06:31:50Z
       
  • Oxygen–Isotope Exchange and Metastable Dissociation in Oxides
    • Authors: W.H. Casey
      Abstract: Publication date: Available online 30 January 2017
      Source:Advances in Inorganic Chemistry
      Author(s): W.H. Casey
      To understand the corrosion of bulk oxide materials at the molecular scale, oxygen–isotope exchanges were examined in two classes of nanometer-sized ions, one cation and one anion, and subsets that differ by targeted single-atom substitutions. In niobate anions, the different oxygen sites within each molecule differ by ∼103–104 in overall rates of isotopic exchange, yet all structural oxygens exhibit similar pH dependencies that relate to the dissociation pathways. In aluminate cations of the ɛ-Keggin structure, single-atom substitutions cause a 107–1010 variation of rates of oxygen–isotopic exchange into two sets of μ2-OH. Molecular-dynamic simulations indicate that metastable forms of these structures exist as loose, long-lived intermediates. A series of common steps is observed to access the intermediate structures, and these are best resolved in the symmetric ɛ-Keggin aluminate ions. In the first step, solvation forces, or a nucleophile, cause a near-surface metal to partly detach from a deeper overbonded oxygen via concerted motions of many atoms. Isotopically distinct oxygens then add to the newly undercoordinated metal in the partly detached metastable state. Protons transfer to more basic oxygens and oxygens shuffle. Finally, the metastable structure collapses and dehydrates. The number of such metastable states depends on the symmetry and composition of the starting structure and access to the metastable state controls the overall rates. Surprisingly, polyoxometalate ions with only 40–100 atoms already seem to capture much of the macroscopic chemistry observed for dissolving minerals and glasses.

      PubDate: 2017-02-17T03:55:34Z
      DOI: 10.1016/bs.adioch.2016.12.007
       
  • Polyoxometalate Multielectron Catalysts in Solar Fuel Production
    • Authors: S.M. Lauinger; Q. Yin; Y.V. Geletii; C.L. Hill
      Abstract: Publication date: Available online 9 February 2017
      Source:Advances in Inorganic Chemistry
      Author(s): S.M. Lauinger, Q. Yin, Y.V. Geletii, C.L. Hill
      Catalysts in solar fuel research have greatly increased in the last few years. Significantly, the development of molecular, selective, and faster catalysts for both water oxidation or water reduction based on polyoxometalates has lead to advances in the understanding of water splitting systems. Recent studies have combined molecular catalysts with substrates or electrode surfaces in order to evaluate these catalysts when immobilized. Quantitative and qualitative investigations of molecular speciation and the catalytic mechanism during water oxidation with polyoxometalates are not simple, but recent reports have provided multiple complementary physicochemical, spectroscopic, and other techniques for the comprehension of catalyst stability. This review provides an up-to-date assessment of polyoxometalate-based water oxidation/reduction catalysts as well as immobilized species for the production of solar fuel.

      PubDate: 2017-02-11T00:52:16Z
      DOI: 10.1016/bs.adioch.2016.12.002
       
  • Perspectives for Polyoxometalates in Single-Molecule Electronics and
           Spintronics
    • Authors: K.Y. Monakhov; M. Moors; P. Kögerler
      Abstract: Publication date: Available online 7 February 2017
      Source:Advances in Inorganic Chemistry
      Author(s): K.Y. Monakhov, M. Moors, P. Kögerler
      Breakthroughs in future information technology mandate new materials. For the most pressing challenges in current information technology—i.e., a drastic decrease in energy dissipation and augmented device functionality beyond classical von Neumann computation architectures—several pathways have been proposed. A particularly promising direction is that of spintronics, where electronic spin state control complements electronic charge-state control (1) . More recently, neuromorphic computing gained significant interest, characterized by a focus on synaptic functionality to realize neural networks and associative memory concepts. In the context of these developments, polyoxometalates, characterized by their unique structural versatility, their potential for functionalization and a highly versatile redox chemistry, provide several key advantages that motivate their exploration and use as single-molecule components of novel electronic and spintronic devices. As will be exemplified in this chapter, polyoxometalates provide near-perfect model systems to study the basic phenomena associated with single-molecule electronics and spintronics. Given the infancy of this field, this chapter thus is intended not a classical review, but as a map of potential departure points for avenues to polyoxometalate-based single-molecule devices.

      PubDate: 2017-02-11T00:52:16Z
      DOI: 10.1016/bs.adioch.2016.12.009
       
  • [Co9(H2O)6(OH)3(HPO4)2(PW9O34)3]16−: A Highly Efficient Catalyst for
           Water Oxidation
    • Authors: J. Soriano-López; S. Goberna-Ferrón; J.J. Carbó; J.M. Poblet; J.R. Galán-Mascarós
      Abstract: Publication date: Available online 4 February 2017
      Source:Advances in Inorganic Chemistry
      Author(s): J. Soriano-López, S. Goberna-Ferrón, J.J. Carbó, J.M. Poblet, J.R. Galán-Mascarós
      Water oxidation catalysis is generally considered one of the major hurdles in the development of an efficient water splitting process. Most available catalysts are either too expensive, too unstable, or too slow for real technological applications. In this chapter we illustrate the major features of an interesting candidate, the nonanuclear polyoxometalate [Co 9 (H2O)6(OH)3(HPO4)2(PW9O34)3]16− (Co9 ). This POM, as others of its kind, has demonstrated to be a robust and fast catalyst promoting oxygen evolution in homogeneous and heterogeneous conditions. In addition to its excellent performance, and prospects, we are including many experimental data that confirm its genuine catalytic activity. This is a key issue since the harsh conditions of oxygen evolution are prone to provoke a major evolution in the catalyst or precatalyst. Being all inorganic and obtained from earth-abundant metals, Co9 matches most of the requirements to be successfully implemented in an overall water splitting process.

      PubDate: 2017-02-04T22:31:35Z
      DOI: 10.1016/bs.adioch.2016.12.008
       
  • Supramolecular Structures Formation of Polyoxometalates in Solution Driven
           by Counterion–Macroion Interaction
    • Authors: Y. Gao; S.A. Eghtesadi; T. Liu
      Abstract: Publication date: Available online 4 February 2017
      Source:Advances in Inorganic Chemistry
      Author(s): Y. Gao, S.A. Eghtesadi, T. Liu
      Hydrophilic macroions, represented by polyoxometalate (POM) clusters, demonstrate unique solution behaviors that are clearly different from simple ions or colloids. Almost all their special features are related to the interaction between the macroions and their counterions, such as their self-assembly into single-layered, hollow, spherical “blackberry” structures in solution due to the counterion-mediated attraction based upon the moderate counterion association around the POM macroions. The delicate macroion–counterion interaction, including the related partial or complete breakage of the water ligands around both parties, enables the macroions to accurately distinguish different types of counterions based on their valence and hydrated size. POM macroions show many amazing properties shared with biological macromolecules, such as ion selectivity, similar kinetic features with the virus capsid formation and the strict self-recognition phenomenon. Understanding and controlling the POM–counterion interactions, such as the distribution of the counterions around and inside the POMs, the counterion exchange near the POMs, as well as the POM–POM interaction in the presence of counterions, is the key to understand the POM solutions and consequently to rationally design functional systems.

      PubDate: 2017-02-04T22:31:35Z
      DOI: 10.1016/bs.adioch.2016.12.006
       
  • Nonaqueous Polyoxometalate Synthesis for Systematic Studies of Hydrolysis,
           Protonation, and Reduction
    • Authors: R.J. Errington
      Abstract: Publication date: Available online 4 February 2017
      Source:Advances in Inorganic Chemistry
      Author(s): R.J. Errington
      Dynamic aspects of polyoxometalate chemistry are often overlooked because of difficulties in monitoring subtle structural and/or speciation changes in solution. This chapter features the nonaqueous approaches to polyoxometalate synthesis being developed in our laboratory as a platform for detailed and systematic reactivity studies. Methods based on metal alkoxide hydrolysis are described that provide access to a range of substituted {M2W4} and {MW5} Lindqvist-type polyoxometalates containing reactive {MX} n+ heterometal sites, and examples are given that highlight the importance of 17O NMR as a tool for monitoring solution reactivity. Lindqvist-type {XTiW5} and {XSnW5} and related Keggin-type {XMPW11} anions are compared, and significant differences in their hydrolysis and condensation behaviors are discussed in relation to DFT studies. The solution reactivity observed upon halide abstraction from {ClTiW5} or protonation of {(RO)TiW5} species is rationalized in terms of a common difunctional reactive intermediate [TiW5O18]2−, which has been characterized in its dimeric form. Following the identification of diprotonated [(μ-O)(TiW5O18H)2]4− a new type of polyoxometalate ligand behavior is proposed, based on the characterization of [(μ-O)(TiW5O18)2(SnMe2)]4−, 17O NMR studies of reactions with electrophiles, and DFT studies of [(μ-O)(TiW5O18)2(AuCl)]4−. The final section describes nonaqueous reductive aggregation reactions of (TBA)3[PMo12O40] that have produced a family of electron-rich anions of the type α-[PMo12O40(ML n ) z ] x−, and the reductive degradation of (TBA)2[Mo6O19] to give the tetra-capped ɛ-[Mo13O40H4{Mg(DMSO)3}4]2+.

      PubDate: 2017-02-04T22:31:35Z
      DOI: 10.1016/bs.adioch.2016.12.010
       
  • Electron Transfer–Oxygen Transfer Reactions and Beyond With
           Polyoxometalates
    • Authors: Neumann
      Abstract: Publication date: Available online 31 January 2017
      Source:Advances in Inorganic Chemistry
      Author(s): R. Neumann
      The unique ability of H5PV2Mo10O40 to catalyze electron transfer–oxygen transfer oxidations via activation of sulfides, and carbon–hydrogen, carbon–carbon, and carbon metal bonds, is discussed in the context of sustainable transformations of arenes, the deconstruction of carbohydrates to synthesis gas as a liquid fuel precursor and the prospects for hydroxylation of alkanes. Emphasis is placed on the mechanistic aspects of these reactions including isolation and or observation of intermediates, and the importance of solvents on the oxidation potential of H5PV2Mo10O40. Descriptions possible structures of reactive intermediates as deduced from EPR spectroscopy and DFT calculations are also included.

      PubDate: 2017-02-04T22:31:35Z
       
  • Design of Magnetic Polyoxometalates for Molecular Spintronics and as Spin
           Qubits
    • Authors: J.J. Baldoví; S. Cardona-Serra; A. Gaita-Ariño; E. Coronado
      Abstract: Publication date: Available online 19 January 2017
      Source:Advances in Inorganic Chemistry
      Author(s): J.J. Baldoví, S. Cardona-Serra, A. Gaita-Ariño, E. Coronado
      In the past decades, POMs have been used as minimal models in Molecular Magnetism, since they are a convenient playing ground to study fundamental phenomena such as anisotropic magnetic exchange and electron transfer. Now they have jumped to the stage of the rational design of single-ion magnets and are being considered as test subjects for simple experiments in Single-Molecule Spintronics and Molecular Quantum Computing. This chapter contains an overview of recent results that demonstrate the potential of POMs in these emerging fields.

      PubDate: 2017-01-23T18:08:06Z
      DOI: 10.1016/bs.adioch.2016.12.003
       
  • Polyoxometalate-Functionalized Nanocarbon Materials for Energy Conversion,
           Energy Storage, and Sensor Systems
    • Authors: C.-G. Lin; J. Hu; Y.-F. Song
      Abstract: Publication date: Available online 19 January 2017
      Source:Advances in Inorganic Chemistry
      Author(s): C.-G. Lin, J. Hu, Y.-F. Song
      The development of advanced composite materials based on polyoxometalates (POMs) and nanostructured carbons has attracted significant attention as they combine the unique chemical reactivity of POMs and the unparalleled electronic properties of nanocarbons. The exceptional properties of the resultant composites have been widely employed in catalysis, energy conversion and storage, molecular sensors and electronics. In this chapter, we report the latest progress on POM/CNT (CNT=carbon nanotubes) and POM/graphene nanocomposites with a focus on energy materials for water splitting and fuel cells, electrode materials for batteries and supercapacitors, as well as functional materials for environmental pollutant sensing. Current applications are critically assessed and promising future target systems are discussed.

      PubDate: 2017-01-23T18:08:06Z
      DOI: 10.1016/bs.adioch.2016.12.004
       
  • Exploring Self-Assembly and the Self-Organization of Nanoscale Inorganic
           Polyoxometalate Clusters
    • Authors: H.N. Miras; D.-L. Long; L. Cronin
      Abstract: Publication date: Available online 19 January 2017
      Source:Advances in Inorganic Chemistry
      Author(s): H.N. Miras, D.-L. Long, L. Cronin
      Polyoxometalates (POMs) are a family of self-assembled molecular clusters with an unmatched range of physical properties, structural features, and sizes. The development of appropriate synthetic methodologies, analytical techniques, and approaches which allow the constructive exploration of the vast parameter space of POM chemistry is crucial for the understanding and control of the underlying complex reactions masked by the self-assembly. This chapter discusses the main aspects of the self-assembly that govern the POM-based chemical systems and the methodologies used for the generation of libraries of molecular synthons that can be used for the construction of large molecular moieties. We will illustrate how the effective combination of synthetic approaches in this area contributed to our deeper understanding of the self-assembly by revealing important mechanistic information. The final sections are devoted to discussing the self-organization of the preassembled molecular components into complex functional macrostructures.

      PubDate: 2017-01-23T18:08:06Z
      DOI: 10.1016/bs.adioch.2016.12.001
       
  • Chapter Six Development of Trackable Anticancer Agents Based on Metal
           Complexes
    • Authors: Ewen Bodio; Pierre Le Gendre; Franck Denat; Christine Goze
      Pages: 253 - 299
      Abstract: Publication date: 2016
      Source:Advances in Inorganic Chemistry, Volume 68
      Author(s): Ewen Bodio, Pierre Le Gendre, Franck Denat, Christine Goze
      The design of trackable anticancer agents is of major interest for the future development of therapeutics based on nonplatinum metal complexes such as Ru(II), Os(II), or Au(I) derivatives, and more particularly for the understanding of the mechanism of action of these metal-based drugs. This review reports the synthesis and the first biological studies of original trackable complexes, in which the metal complex was coupled to an imaging probe, such as a fluorophore (coumarin, borodipyrromethene derivative (BODIPY), porphyrin), or a chelating agent (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)) for radioisotopic imaging PET (positron emission tomography) or SPECT (single photon emission computed tomography). In the case of fluorescent theranostics, the photophysical properties of the different compounds were studied and the cell uptake could be evaluated on different cell lines, by microscopy imaging. A fluorescent smart probe based on coumarin-phosphine, whose fluorescence strongly depends on the coordination of the metal was also studied, revealing a nonusual cellular target with respect to the classical gold therapeutic systems. In the last section, the synthesis of new potential fluorescent trackable-radiotherapeutics is also presented.

      PubDate: 2016-02-12T23:17:14Z
      DOI: 10.1016/bs.adioch.2015.09.004
      Issue No: Vol. 68 (2016)
       
  • Chapter Seven Advanced Chelator Design for Metal Complexes in Imaging
           Applications
    • Authors: Benjamin P. Burke; Johanna Seemann; Stephen J. Archibald
      Pages: 301 - 339
      Abstract: Publication date: 2016
      Source:Advances in Inorganic Chemistry, Volume 68
      Author(s): Benjamin P. Burke, Johanna Seemann, Stephen J. Archibald
      Chelating ligands can be designed to control the interactions of metal complexes with biological systems with specific relevance to molecular imaging techniques. Properties of interest include the stability of the complex under physiological conditions and how the complex will interact with biological macromolecules including proteins, genetic material, and polysaccharides. In medical imaging applications, targeting specific organs or disease sites, the metal complex will most commonly have the requirement of it being delivered to the site of interest, cleared from the other organs (followed by imaging), and then ultimately excreted remaining intact throughout. Design features such as rigidity, donor atom type and arrangement, and cavity size can be tuned to optimize the specificity, stability, and kinetics of binding. Examples are presented on chelator design for radiopharmaceuticals, how targeting for imaging can be achieved utilizing metal complexes that bind to specific proteins and how chelators can be modified for attachment (bioconjugation) to antibodies and peptides as bifunctional chelators.

      PubDate: 2016-02-12T23:17:14Z
      DOI: 10.1016/bs.adioch.2015.11.002
      Issue No: Vol. 68 (2016)
       
  • Chapter Eight Radiometallo-Labeled Peptides in Tumor Diagnosis and
           Targeted Radionuclide Therapy
    • Authors: Subhani M. Okarvi; Helmut R. Maecke
      Pages: 341 - 396
      Abstract: Publication date: 2016
      Source:Advances in Inorganic Chemistry, Volume 68
      Author(s): Subhani M. Okarvi, Helmut R. Maecke
      Radiometal-labeled peptides are promising biologic tools for a new generation of radiopharmaceuticals, because their receptors frequently are overexpressed in many human tumors that can be targeted efficiently with suitably designed tumor receptor-binding peptide radiopharmaceuticals. The main focus of molecular imaging is to study the biochemical processes at cellular and subcellular levels in order to detect abnormalities associated with various diseases. For that purpose, biomolecules that selectively accumulate in the organ or tissue of interest by a specific mechanism such as receptor binding or interaction with biomolecules are radiolabeled with 99mTc, 68Ga, 111In, 64Cu, 177Lu, 90Y, among others and used as radiopharmaceuticals. However, significant effort is still necessary to combine these medically useful radionuclides with clinically important biomolecules relevant to different pathological conditions. Extensive research on the coordination chemistry of these metals has led to new radiolabeling methods that yield stable compounds which retained the original biological activity of the ligand. Each metal is unique and is defined by its oxidation state, coordination number, hard–soft characteristics, kinetic inertness or lability, and redox stability. In addition to complexing the radiometal in a kinetically inert environment, the chelate often has the dual function of also covalently bonding to the tumor-targeting peptide for directing the radiopharmaceutical to its in vivo target site, such as tumors. Here, some characteristics of radiometallo-labeled peptides in tumor diagnosis and therapy are presented with particular emphasis on somatostatin peptides. Some special peptides targeting bombesin and chemokine receptor 4 that have been preclinically or clinically investigated are briefly described. Additionally, promising bifunctional chelators and radioisotopes for radiometal labeling are reviewed.

      PubDate: 2016-02-12T23:17:14Z
      DOI: 10.1016/bs.adioch.2015.11.003
      Issue No: Vol. 68 (2016)
       
  • Chapter Nine Labeling of Graphene, Graphene Oxides, and of Their Congeners
    • Authors: James A. Tyson; David G. Calatayud; Vincenzo Mirabello; Boyang Mao; Sofia I. Pascu
      Pages: 397 - 440
      Abstract: Publication date: 2016
      Source:Advances in Inorganic Chemistry, Volume 68
      Author(s): James A. Tyson, David G. Calatayud, Vincenzo Mirabello, Boyang Mao, Sofia I. Pascu
      The area of biomedical imaging is fast becoming an active focus for the utilization of graphene within a variety of imaging modalities. Graphene can be oxidized to produce a material with a high degree of functionality and has led to its expansion as a platform for the immobilization of fluorescent and radiolabeled molecules. Its large surface area has allowed graphene and its oxides to be modified with a variety of molecules that enhance biocompatibility, selectivity, and therapeutic potential. This chapter highlights recent developments in the use of targeted fluorogenic or radiolabeled graphene materials that can be used to image cancers via fluorescence, positron emission tomography, and single-photon emission computed tomography modalities. Key emphasis is placed on the nanocomposites that are designed to provide additional therapeutic effects. The capacity of these composites to be internalized by cells and tumors is discussed to appreciate the future perspective of graphene and its congeners as therapeutic multimodal imaging agents.

      PubDate: 2016-02-12T23:17:14Z
      DOI: 10.1016/bs.adioch.2015.09.007
      Issue No: Vol. 68 (2016)
       
  • Chapter Ten The Chemistry of Monovalent Copper in Solutions of Pure and
           Mixed Nonaqueous Solvents
    • Authors: Dip Gill; Vivek Pathania
      Pages: 441 - 481
      Abstract: Publication date: 2016
      Source:Advances in Inorganic Chemistry, Volume 68
      Author(s): Dip Gill, Vivek Pathania
      This review presents some important and recent research especially 63Cu/65Cu NMR studies and compressibility studies of monovalent copper (Cu(I)) in mixtures of AN or BN with a large number of nonaqueous solvents including some other nitriles. Syntheses of some rare and novel Cu(I) salts [CuX∙4AN] (where X = C l O 4 − , NO 3 − , B F 4 − , P F 6 − , H S O 4 − , SO 4 2 − , and C F 3 C O O − ) and their corresponding derivatives such as CuX∙2DMPhen with organic ligands, for example, DMPhen, have also been reported. Physicochemical techniques such as molar conductance, viscosity, compressibility, and 63Cu/65Cu NMR have been used to investigate the solvation behavior of Cu(I). Two derived parameters, i.e., the solvated radii (r i) and Cu quadrupole coupling constant (e 2 Qq/h) were used to obtain quantitative information on the solvation behavior of Cu(I). The variation of r i and (e 2 Qq/h) with mol% cosolvent in AN+cosolvent mixtures has been used to highlight the extent of preferential solvation behavior of Cu(I) and the formation, nature, and symmetry of solvated mixed complexes of Cu(I) such as [Cu(AN)4(S)4− x ]+ (x =0–4). In several cases of mixed solvents, AN exhibits preferential solvation. Py, TRP, and BN, however, showed preferential solvation in AN+Py, AN+TRP, and AN+BN mixtures. TRP, even at a very low concentration (0.001M), demonstrated a strong interaction with Cu(I) resulting in the splitting of the Cu signal into five peaks by coupling of the Cu signal with 31P from four molecules of TRP.

      PubDate: 2016-02-12T23:17:14Z
      DOI: 10.1016/bs.adioch.2015.11.001
      Issue No: Vol. 68 (2016)
       
  • Series Page
    • Abstract: Publication date: 2016
      Source:Advances in Inorganic Chemistry, Volume 68


      PubDate: 2016-02-12T23:17:14Z
       
  • Chapter One Opportunities and Challenges for Metal Chemistry in Molecular
           Imaging
    • Authors: Richard Southworth; Rafael Torres Martin Rosales Levente Meszaros Michelle Gregory
      Abstract: Publication date: 2016
      Source:Advances in Inorganic Chemistry, Volume 68
      Author(s): Richard Southworth, Rafael Torres Martin de Rosales, Levente K. Meszaros, Michelle T. Ma, Gregory E.D. Mullen, Gilbert Fruhwirth, Jennifer D. Young, Cinzia Imberti, Julia Bagunya-Torres, Erica Andreozzi, Philip J. Blower
      The development of medical imaging is a highly multidisciplinary endeavor requiring the close cooperation of clinicians, physicists, engineers, biologists, and chemists to identify capabilities, conceive challenges and solutions and apply them in the clinic. The chemistry described in this chapter illustrates how synergistic advances in these areas drive the technology and its applications forward, with each discipline producing innovations that in turn drive innovations in the others. The main thread running through the chapter is the shift from single photon radionuclide imaging toward PET, and in turn the emerging shift from PET/CT toward PET/MRI and further, combination of these with optical imaging. Chemistry to support these transitions is exemplified by building on a summary of the status quo, and recent developments, in technetium-99m chemistry for SPECT imaging, followed by a report of recent developments to support clinical application of short-lived (Ga-68) and long-lived (Zr-89) positron-emitting isotopes, copper isotopes for PET imaging, and combined modality imaging agents based on radiolabeled iron oxide-based nanoparticles.

      PubDate: 2016-02-12T23:17:14Z
       
  • Chapter Two Molecular Magnetic Resonance Imaging Probes Based on Ln3+
           Complexes
    • Authors: Bonnet
      Abstract: Publication date: 2016
      Source:Advances in Inorganic Chemistry, Volume 68
      Author(s): Célia S. Bonnet, Éva Tóth
      For almost three decades, the application of Gd3+ complexes as contrast-enhancing agents has largely contributed to the successful use of magnetic resonance imaging (MRI) both in the clinics and in biomedical research. More recently, the emergence of paramagnetic Chemical Exchange Saturation Transfer (ParaCEST) agents, most often based on lanthanide chelates, opened new possibilities to create MRI contrast. Via a judicious ligand design, the efficacy of Gd3+ complexes or the CEST effect of ParaCEST agents can be modulated by a variety of physical–chemical parameters (pH, temperature, ion concentration, etc.) or by interaction with biomarkers. This allows developing responsive probes, capable of reporting on different properties of the surrounding tissue. We survey recent contributions in the field of responsive probes for detection of enzymes, biologically important cations, or neurotransmitters. The specificity of a molecular probe can be improved by selectively delivering it to a specific target. Discrete MR probes can be adapted to visualize abundant targets. An important challenge is to retain the affinity of the vector for its target upon conjugation to paramagnetic chelates. These issues are discussed in the context of imaging of amyloid aggregates by Gd3+ complexes. To ascertain MRI findings, the possible detection of the probe in optical imaging is often explored. For this, imaging agents need to combine features required by MRI and optical imaging. We review approaches including both small molecular probes and nanoparticles. Finally, different nonconventional systems such as metal-organic frameworks, rotaxanes, or zeolites are discussed as potential MRI probes.

      PubDate: 2016-02-12T23:17:14Z
       
  • Chapter Three Luminescent Iridium(III) and Rhenium(I) Complexes as
           Biomolecular Probes and Imaging Reagents
    • Authors: Kenneth Kam-Wing
      Abstract: Publication date: 2016
      Source:Advances in Inorganic Chemistry, Volume 68
      Author(s): Kenneth Kam-Wing Lo
      There is an emerging interest in the applications of luminescent transition metal complexes as biological probes and imaging reagents due to their interesting photophysical properties, which include high photostability, long emission lifetimes, large Stokes’ shifts, and highly environment-sensitive emission. The involvement of heavy metal implies that the quantitation of cellular uptake can be conveniently performed by inductively coupled plasma mass spectrometry. For more than a decade, we have developed a number of luminescent transition metal complexes that carry a reactive functional group for bioconjugation. Additionally, we have incorporated different biological substrates within transition metal complexes that show highly environment-sensitive emission and exploited them as noncovalent probes for biomolecules such as nucleic acids and proteins. In the past several years, we have also developed an interest in the cellular studies of related complexes. Different functional moieties have been appended to luminescent transition metal complexes with a variety of spacer-arms to afford new cellular reagents. The functional moieties include biotin, indole, estradiol, alkyl and fluorous chains, intercalating units, dendritic skeleton, reactive functional groups such as isothiocyanate and aldehyde, ion and molecule sensing units, polymeric chains such as poly(ethylene glycol) and poly(ethyleneimine), carbohydrates, and chemical probes for bioorthogonal labeling. In this chapter, we have summarized the molecular design and photophysical properties of a selection of these metal complexes developed in our laboratory. The cellular uptake, cytotoxicity, intracellular trafficking and localization, and the potential biological applications (such as sensing, bioimaging, and photoinduced cytotoxicity) of these complexes have been described.

      PubDate: 2016-02-12T23:17:14Z
       
  • Chapter Four Metalloporphyrins for Medical Imaging Applications
    • Authors: Francesca Bryden; Ross Boyle
      Abstract: Publication date: 2016
      Source:Advances in Inorganic Chemistry, Volume 68
      Author(s): Francesca Bryden, Ross W. Boyle
      In this account, the synthesis and biological evaluation of metalloporphyrins and related structures for use in biomedical imaging applications are outlined. The structural design of these tetrapyrrolic metal chelators is discussed, with evaluation of strategies designed to facilitate more rapid chelation under milder conditions, improve water solubility, and allow for conjugation to targeting groups and macromolecular structures. Particular emphasis is given to the application of these metalloporphyrin structures to clinically relevant imaging techniques including magnetic resonance imaging, fluorescence imaging, radio-imaging, and Raman and photo-acoustic imaging, with a broad overview of the progress made in these areas. The future of research in this area is also examined, with the emerging research interest in more modern multimodal imaging set to dominate the future of biomedical imaging.

      PubDate: 2016-02-12T23:17:14Z
       
  • Chapter Five Macrocyclic Bifunctional Chelators and Conjugation Strategies
           for Copper-64 Radiopharmaceuticals
    • Authors: Brett Paterson; Paul Donnelly
      Abstract: Publication date: 2016
      Source:Advances in Inorganic Chemistry, Volume 68
      Author(s): Brett M. Paterson, Paul S. Donnelly
      The positron-emitting radionuclide copper-64 is of interest in the development of new molecular imaging agents for use with positron emission tomography. This account highlights the development and application of macrocyclic chelators that have been designed to form complexes of copper-64 that are exceptionally stable in vivo and can be readily conjugated to biologically active molecules and nanoparticles. “Click chemistry” is discussed as a conjugation technique that is bioorthogonal with both pre- and postlabeling capabilities. Enzyme-mediated site-specific strategies are introduced as new conjugation techniques with the potential to improve homogeneity, reproducibility, and the likelihood for retention of full biological function of targeted tracers for noninvasive diagnostic imaging.

      PubDate: 2016-02-12T23:17:14Z
       
  • Contents of Previous Volumes
    • Abstract: Publication date: 2016
      Source:Advances in Inorganic Chemistry, Volume 68


      PubDate: 2016-02-12T23:17:14Z
       
 
 
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