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Publisher: Elsevier   (Total: 3168 journals)

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Showing 1 - 200 of 3168 Journals sorted alphabetically
Academic Pediatrics     Hybrid Journal   (Followers: 39, SJR: 1.655, CiteScore: 2)
Academic Radiology     Hybrid Journal   (Followers: 26, SJR: 1.015, CiteScore: 2)
Accident Analysis & Prevention     Partially Free   (Followers: 105, SJR: 1.462, CiteScore: 3)
Accounting Forum     Hybrid Journal   (Followers: 28, SJR: 0.932, CiteScore: 2)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 42, SJR: 1.771, CiteScore: 3)
Achievements in the Life Sciences     Open Access   (Followers: 7)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 6)
Acta Astronautica     Hybrid Journal   (Followers: 454, SJR: 0.758, CiteScore: 2)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 2)
Acta Biomaterialia     Hybrid Journal   (Followers: 30, SJR: 1.967, CiteScore: 7)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 3)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 11, SJR: 0.18, CiteScore: 1)
Acta Histochemica     Hybrid Journal   (Followers: 5, SJR: 0.661, CiteScore: 2)
Acta Materialia     Hybrid Journal   (Followers: 330, SJR: 3.263, CiteScore: 6)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.504, CiteScore: 1)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.542, CiteScore: 1)
Acta Oecologica     Hybrid Journal   (Followers: 12, SJR: 0.834, CiteScore: 2)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription  
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 2, SJR: 0.307, CiteScore: 0)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 2, SJR: 1.793, CiteScore: 6)
Acta Poética     Open Access   (Followers: 4, SJR: 0.101, CiteScore: 0)
Acta Psychologica     Hybrid Journal   (Followers: 26, SJR: 1.331, CiteScore: 2)
Acta Sociológica     Open Access   (Followers: 1)
Acta Tropica     Hybrid Journal   (Followers: 7, SJR: 1.052, CiteScore: 2)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3, SJR: 0.374, CiteScore: 1)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.344, CiteScore: 1)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 1)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 7, SJR: 0.19, CiteScore: 0)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 3)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 8)
Acute Pain     Full-text available via subscription   (Followers: 15, SJR: 2.671, CiteScore: 5)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.53, CiteScore: 4)
Addictive Behaviors     Hybrid Journal   (Followers: 18, SJR: 1.29, CiteScore: 3)
Addictive Behaviors Reports     Open Access   (Followers: 9, SJR: 0.755, CiteScore: 2)
Additive Manufacturing     Hybrid Journal   (Followers: 13, SJR: 2.611, CiteScore: 8)
Additives for Polymers     Full-text available via subscription   (Followers: 23)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 199, SJR: 4.09, CiteScore: 13)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 12, SJR: 1.167, CiteScore: 4)
Advanced Powder Technology     Hybrid Journal   (Followers: 17, SJR: 0.694, CiteScore: 3)
Advances in Accounting     Hybrid Journal   (Followers: 9, SJR: 0.277, CiteScore: 1)
Advances in Agronomy     Full-text available via subscription   (Followers: 17, SJR: 2.384, CiteScore: 5)
Advances in Anesthesia     Full-text available via subscription   (Followers: 30, SJR: 0.126, CiteScore: 0)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 2)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 12, SJR: 0.992, CiteScore: 1)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 12, SJR: 1.551, CiteScore: 4)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 24, SJR: 2.089, CiteScore: 5)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 15, SJR: 0.572, CiteScore: 2)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.61, CiteScore: 7)
Advances in Botanical Research     Full-text available via subscription   (Followers: 1, SJR: 0.686, CiteScore: 2)
Advances in Cancer Research     Full-text available via subscription   (Followers: 35, SJR: 3.043, CiteScore: 6)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 1.453, CiteScore: 2)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 1.992, CiteScore: 5)
Advances in Cell Aging and Gerontology     Full-text available via subscription   (Followers: 5)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 14)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 29, SJR: 0.156, CiteScore: 1)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 11, SJR: 0.713, CiteScore: 1)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 11, SJR: 1.316, CiteScore: 2)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 26, SJR: 1.562, CiteScore: 3)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 20, SJR: 1.977, CiteScore: 8)
Advances in Computers     Full-text available via subscription   (Followers: 14, SJR: 0.205, CiteScore: 1)
Advances in Dermatology     Full-text available via subscription   (Followers: 16)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 13)
Advances in Digestive Medicine     Open Access   (Followers: 12)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 7)
Advances in Drug Research     Full-text available via subscription   (Followers: 26)
Advances in Ecological Research     Full-text available via subscription   (Followers: 44, SJR: 2.524, CiteScore: 4)
Advances in Engineering Software     Hybrid Journal   (Followers: 29, SJR: 1.159, CiteScore: 4)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 8)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 52, SJR: 5.39, CiteScore: 8)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 1)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 9)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 67, SJR: 0.591, CiteScore: 2)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 17)
Advances in Genetics     Full-text available via subscription   (Followers: 21, SJR: 1.354, CiteScore: 4)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11, SJR: 12.74, CiteScore: 13)
Advances in Geophysics     Full-text available via subscription   (Followers: 7, SJR: 1.193, CiteScore: 3)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 26, SJR: 0.368, CiteScore: 1)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 11, SJR: 0.749, CiteScore: 3)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 26)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 3, SJR: 0.193, CiteScore: 0)
Advances in Immunology     Full-text available via subscription   (Followers: 37, SJR: 4.433, CiteScore: 6)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 10, SJR: 1.163, CiteScore: 2)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 2, SJR: 1.938, CiteScore: 3)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6, SJR: 0.176, CiteScore: 0)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 3)
Advances in Life Course Research     Hybrid Journal   (Followers: 9, SJR: 0.682, CiteScore: 2)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 8)
Advances in Marine Biology     Full-text available via subscription   (Followers: 21, SJR: 0.88, CiteScore: 2)
Advances in Mathematics     Full-text available via subscription   (Followers: 15, SJR: 3.027, CiteScore: 2)
Advances in Medical Sciences     Hybrid Journal   (Followers: 9, SJR: 0.694, CiteScore: 2)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 5, SJR: 1.158, CiteScore: 3)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 25)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 8)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.182, CiteScore: 0)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 5)
Advances in Oncobiology     Full-text available via subscription   (Followers: 2)
Advances in Organ Biology     Full-text available via subscription   (Followers: 2)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 18, SJR: 1.875, CiteScore: 4)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.174, CiteScore: 0)
Advances in Parasitology     Full-text available via subscription   (Followers: 5, SJR: 1.579, CiteScore: 4)
Advances in Pediatrics     Full-text available via subscription   (Followers: 27, SJR: 0.461, CiteScore: 1)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 19)
Advances in Pharmacology     Full-text available via subscription   (Followers: 17, SJR: 1.536, CiteScore: 3)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 0.574, CiteScore: 1)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.109, CiteScore: 1)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 11)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 6)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 19)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20, SJR: 0.791, CiteScore: 2)
Advances in Psychology     Full-text available via subscription   (Followers: 68)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 6, SJR: 0.371, CiteScore: 1)
Advances in Radiation Oncology     Open Access   (Followers: 3, SJR: 0.263, CiteScore: 1)
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.101, CiteScore: 0)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 6)
Advances in Space Research     Full-text available via subscription   (Followers: 437, SJR: 0.569, CiteScore: 2)
Advances in Structural Biology     Full-text available via subscription   (Followers: 5)
Advances in Surgery     Full-text available via subscription   (Followers: 13, SJR: 0.555, CiteScore: 2)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 37, SJR: 2.208, CiteScore: 4)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 20)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 15)
Advances in Virus Research     Full-text available via subscription   (Followers: 6, SJR: 2.262, CiteScore: 5)
Advances in Water Resources     Hybrid Journal   (Followers: 55, SJR: 1.551, CiteScore: 3)
Aeolian Research     Hybrid Journal   (Followers: 6, SJR: 1.117, CiteScore: 3)
Aerospace Science and Technology     Hybrid Journal   (Followers: 396, SJR: 0.796, CiteScore: 3)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.42, CiteScore: 2)
African J. of Emergency Medicine     Open Access   (Followers: 6, SJR: 0.296, CiteScore: 0)
Ageing Research Reviews     Hybrid Journal   (Followers: 12, SJR: 3.671, CiteScore: 9)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 492, SJR: 1.238, CiteScore: 3)
Agri Gene     Hybrid Journal   (Followers: 1, SJR: 0.13, CiteScore: 0)
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 18, SJR: 1.818, CiteScore: 5)
Agricultural Systems     Hybrid Journal   (Followers: 32, SJR: 1.156, CiteScore: 4)
Agricultural Water Management     Hybrid Journal   (Followers: 45, SJR: 1.272, CiteScore: 3)
Agriculture and Agricultural Science Procedia     Open Access   (Followers: 4)
Agriculture and Natural Resources     Open Access   (Followers: 3)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 58, SJR: 1.747, CiteScore: 4)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.589, CiteScore: 3)
Air Medical J.     Hybrid Journal   (Followers: 8, SJR: 0.26, CiteScore: 0)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.19, CiteScore: 0)
Alcohol     Hybrid Journal   (Followers: 12, SJR: 1.153, CiteScore: 3)
Alcoholism and Drug Addiction     Open Access   (Followers: 12)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 2, SJR: 0.604, CiteScore: 3)
Alexandria J. of Medicine     Open Access   (Followers: 1, SJR: 0.191, CiteScore: 1)
Algal Research     Partially Free   (Followers: 11, SJR: 1.142, CiteScore: 4)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.504, CiteScore: 1)
Allergology Intl.     Open Access   (Followers: 5, SJR: 1.148, CiteScore: 2)
Alpha Omegan     Full-text available via subscription   (SJR: 3.521, CiteScore: 6)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 11, SJR: 0.201, CiteScore: 1)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 54, SJR: 4.66, CiteScore: 10)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 6, SJR: 1.796, CiteScore: 4)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 6, SJR: 1.108, CiteScore: 3)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 5)
American Heart J.     Hybrid Journal   (Followers: 58, SJR: 3.267, CiteScore: 4)
American J. of Cardiology     Hybrid Journal   (Followers: 67, SJR: 1.93, CiteScore: 3)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 47, SJR: 0.604, CiteScore: 1)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 13)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.524, CiteScore: 3)
American J. of Human Genetics     Hybrid Journal   (Followers: 37, SJR: 7.45, CiteScore: 8)
American J. of Infection Control     Hybrid Journal   (Followers: 29, SJR: 1.062, CiteScore: 2)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 37, SJR: 2.973, CiteScore: 4)
American J. of Medicine     Hybrid Journal   (Followers: 50)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3, SJR: 1.967, CiteScore: 2)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 279, SJR: 2.7, CiteScore: 4)
American J. of Ophthalmology     Hybrid Journal   (Followers: 66, SJR: 3.184, CiteScore: 4)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 5, SJR: 0.265, CiteScore: 0)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.289, CiteScore: 1)
American J. of Otolaryngology     Hybrid Journal   (Followers: 25, SJR: 0.59, CiteScore: 1)
American J. of Pathology     Hybrid Journal   (Followers: 32, SJR: 2.139, CiteScore: 4)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 28, SJR: 2.164, CiteScore: 4)
American J. of Surgery     Hybrid Journal   (Followers: 39, SJR: 1.141, CiteScore: 2)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.767, CiteScore: 1)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 7)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.144, CiteScore: 3)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 67, SJR: 0.138, CiteScore: 0)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 25, SJR: 0.411, CiteScore: 1)
Anales de Cirugia Vascular     Full-text available via subscription   (Followers: 1)
Anales de Pediatría     Full-text available via subscription   (Followers: 3, SJR: 0.277, CiteScore: 0)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription  
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 5, SJR: 4.849, CiteScore: 10)
Analytica Chimica Acta     Hybrid Journal   (Followers: 44, SJR: 1.512, CiteScore: 5)
Analytica Chimica Acta : X     Open Access  
Analytical Biochemistry     Hybrid Journal   (Followers: 221, SJR: 0.633, CiteScore: 2)
Analytical Chemistry Research     Open Access   (Followers: 13, SJR: 0.411, CiteScore: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 14)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 2)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 25, SJR: 0.683, CiteScore: 2)
Angiología     Full-text available via subscription   (SJR: 0.121, CiteScore: 0)
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1, SJR: 0.111, CiteScore: 0)
Animal Behaviour     Hybrid Journal   (Followers: 237, SJR: 1.58, CiteScore: 3)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 7, SJR: 0.937, CiteScore: 2)
Animal Reproduction Science     Hybrid Journal   (Followers: 7, SJR: 0.704, CiteScore: 2)

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Similar Journals
Journal Cover
Advances in Chemical Engineering
Journal Prestige (SJR): 0.156
Citation Impact (citeScore): 1
Number of Followers: 29  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0065-2377
Published by Elsevier Homepage  [3168 journals]
  • Series Page
    • Abstract: Publication date: 2019Source: Advances in Chemical Engineering, Volume 54Author(s):
       
  • Population balances in partitioning bioreactors: Cell heterogeneity
    • Abstract: Publication date: Available online 7 May 2019Source: Advances in Chemical EngineeringAuthor(s): Abhishek Dutta, Turgut ÖzisAbstractMicrobial cell populations are typically described by averaged properties although individual cells present a certain degree of variability in properties such as age and mass even when growing in a homogeneous environment. Understanding cell heterogeneity is crucial because, in a partitioning bioreactor, the microbial cells are kept at the desired state of metabolic activity by adjusting the nutrient levels and reactor variables. In order to address the implications of heterogeneity, the so-called population balance model (PBM) approach is used. The chapter proposes a novel numerical approach based on an improved spectral method, to solve the bivariate (age-mass) cell population balance model when non-linear growth is considered. The method is faster than the conventional higher order finite difference approaches and is slightly different from the conventional spectral method in two ways, namely the choice of the basis functions and the method to obtain the time evolution of the coefficients.
       
  • Multiphase bioreactors in the pharmaceutical industry
    • Abstract: Publication date: Available online 22 April 2019Source: Advances in Chemical EngineeringAuthor(s): Rodrigo Melgarejo-Torres, Samuel B. Pérez-Vega, Victor M. Rivera-Arredondo, Gamaliel Che-GaliciaAbstractThis chapter covers the basics for the production of metabolites of pharmaceutical interest and typical downstream operations involved after partitioning bioreactors. The production of bicyclic lactones used for producing cosmetics and drug precursors is considered a case study. In this chapter the reader will find: the importance of the product, the strain used (genetically modified), the study of the well-founded kinetic models of bioconversion and deactivation both cellular and enzymatic that affect productivity in the bioprocess. Furthermore, a study of how to choose the appropriate selection of the dispersed phase (profitability, partition coefficients of substrate, and product and toxicity toward the cell), mass transport mechanisms (operating conditions) and the bioconversion can be found within. Therefore, using multiphase bioreactors is proposed as a strategy (Regime analysis). The aim of this strategy is to obtain the main limiting step of the bioprocess by comparing the characteristic times of the mechanisms that occur in multiphase bioreactors (MPB). Finally, the most typical downstream operations to follow after an active pharmaceutical ingredient (API) has been successfully manufactured by a multiphase bioreactor will be covered. Their successful implementation, sustainability, economic feasibility, as well as scale up implications will be discussed. As a result, downstream options will be explored from a holistic perspective in order to select the best choice from an early stage of process development.
       
  • Monitoring and evaluation of multi-phase bioprocesses using an in-line
           bio-cell analyzer
    • Abstract: Publication date: Available online 12 March 2019Source: Advances in Chemical EngineeringAuthor(s): Maryam Fardmostafavi, Friedel H. Schwartz, Hermann B. SchwartzAbstractThe concept of two phase bio reactors is extensively described and examples are presented to more clarify various applications of this mentioned bioreactors.In addition, bio cell analyzer (SEQUIP S + E GmbH) as a robust and reliable technology is introduced and proved that this technology is able to track and monitor changes in cell shape, size, density, viability, counts as well as to analyze and evaluate events such as cell growth, cell lethal injuries, cell toxicity, cell agglomeration in-line and in-real time. The case studies demonstrated and proved that bio cell analyzer enabling users to monitor, understand, optimize final product and process efficiently and accurately.
       
  • Multiphase partitioning airlift bioreactors: An alternative for
           hydrocarbon biodegradation in contaminated environments
    • Abstract: Publication date: Available online 6 March 2019Source: Advances in Chemical EngineeringAuthor(s): Sergio Valdivia-Rivera, Manuel Alejandro Lizardi-Jiménez, Sergio Alejandro Medina-Moreno, Victor Sánchez-VázquezAbstractAirlift bioreactor (ALB) is a multiphasic pneumatic system agitated with gas phase bubbles that break toward the liquid phase, resulting in an isothermal expansion that keeps pseudo-homogeneity within the bioreactor. ALBs are extensively used in biotechnology. However, scarce information is available about environmental purposes, e.g., hydrocarbon biodegradation. This chapter is focused on describing the applicability of the airlift bioreactors for hydrocarbon biodegradation, considering some advantages and disadvantages; these could be evaluated by experimental way or via mathematical modeling and simulation. This chapter reviews: (i) an overview of hydrocarbon pollution, (ii) microbial uptake by direct contact and emulsified forms, (iii) bacterial uptake, (iv) fungal uptake, (v) airlift bioreactors as hydrocarbon remediation alternative, (vi) immobilized microorganisms in airlift bioreactors and (vii) mathematical modeling.
       
  • Mathematical modeling of mass transport in partitioning bioreactors
    • Abstract: Publication date: Available online 5 March 2019Source: Advances in Chemical EngineeringAuthor(s): Gladys Jiménez-García, Rafael Maya-YescasAbstractSo-called two-phase partitioning bioreactors (TPPBs), like many other reactors, are the heart of production process. Additionally, they are among the most interesting reacting operations, mainly because of their particular characteristics, such as multiphase nature, complex mass transport phenomena, bio-catalytic kinetics, and the intensified design consequence of the incorporation of a second liquid phase. TPPBs are multiphase systems which consist of an aqueous phase, usually containing microorganisms, and an immiscible and biocompatible organic phase that partitions toxic/insoluble substrates/products to the cells. This partition seems to favor metabolic demands, as well as thermodynamic liquid–liquid equilibrium of the system. Nevertheless the most important effect of the partition is improving mass transfer inside the liquid phase; otherwise cells are isolated from nutrients. Particular emphasis has been placed on assessing the nature of organism's interaction with the aqueous-organic interphase. Therefore, proper understanding of these bioreactors needs multidisciplinary participation; however mathematical modeling belongs to the field of reactor engineering. Additionally, TPPBs are quasi-isothermal systems as consequence of their biological nature; therefore their dynamics is governed by characteristic times of mass transport across interphases versus characteristic times of biological reaction. The elucidation of the processes responsible for gaseous substrate (mainly oxygen) mass transport is crucial to achieve optimum design of TPPBs, either in oxygen limited fermentations or in the off-gas treatment of volatile organic contaminants. This chapter, first defines the phases present in this kind of reactors and second introduces the basis of the “method of volume averaging” to propose and evaluate characteristic times in the liquid phase. Later, a macroscopic approach to the gas phase is developed, in order to obtain characteristic times for mass transfer limited systems. Both sets of characteristic parameters are compared finding useful interpretations of characteristic times and probable controlling steps. Finally, brief analyses of some experimental studies in literature are performed; it is found that conclusions obtained by the mathematical models analysis performed in this chapter are in agreement with experimental results reported previously.
       
  • Advances and applications of partitioning bioreactors
    • Abstract: Publication date: Available online 20 February 2019Source: Advances in Chemical EngineeringAuthor(s): Dulce María Palmerín-Carreño, Itza Nallely Cordero-Soto, Sergio Valle-Cervantes, Leticia Guadalupe Ríos-Nuñez, Lilia Arely Prado-Barragán, Olga Miriam Rutiaga-QuiñonesAbstractFlavor and aroma molecules (FAMs) are high-value compounds used as safe additives to increase the sensorial properties of product formulations. Natural production of these compounds is preferred by consumers; hence, several strategies for this have been developed over time, including the use of biological systems such as bacteria, fungus, and yeast. However, most of these microorganisms are inhibited by the substrate or the product, limiting production. Continued development in bioreactor design to overcome these limitations has been reported, especially in the use of partitioning bioreactors. The concept of partitioning bioreactors presents great potential for improving the productivity of several bioprocesses. The proper selection of the dispersed phase is the key to the successful application of this approach in industrial practice. The integration of the bioprocess and the separation of the product have a positive impact on the productivity of FAMs processes. Controlling the supply of the substrate from the dispersed to the aqueous phase opens a new application for this strategy in the production and bioconversion of FAMs. However, it is necessary for the academic community to continue studying partitioning reactors and the phenomena that occur in such reactors in bioconversion systems used for the production of flavor and aroma molecules.
       
  • Mass transport phenomena in multiphasic gas/water/NAP systems
    • Abstract: Publication date: Available online 20 February 2019Source: Advances in Chemical EngineeringAuthor(s): Éric DumontAbstractThis chapter describes the mass transfer characteristics in gas/water/organic solvent systems. The ability of an organic solvent (called NAP, i.e., Non Aqueous Phase) to influence the gas transfer of solutes (Volatile Organic Compounds, VOCs, or oxygen) from the gas phase to the aqueous phase and to affect the gas/liquid interface and the volumetric mass transfer coefficient KLa is considered. The objective of the chapter is to summarize the current knowledge in the comprehension of mass transfer mechanisms. The influent parameters and the possible mass transfer mechanisms are described. Theoretical mass transfer enhancements that could be reached are quantified and compared with experimental data. Moreover, new insights based on the “Equivalent Absorption Capacity” concept are given. Coupled with the ɛ-NTU method, this concept could be used for the determination of the overall mass transfer coefficient KLa in multiphasic gas/water/NAP systems.
       
  • Biological treatment of gas pollutants in partitioning bioreactors
    • Abstract: Publication date: Available online 18 February 2019Source: Advances in Chemical EngineeringAuthor(s): Raquel Lebrero, Osvaldo David Frutos, Victor Pérez, Sara Cantera, José Manuel Estrada, Raúl MuñozAbstractThe off-gas treatment of hydrophobic pollutants in conventional biotechnologies is typically limited by the gas-liquid mass transfer as a result of the low-concentration gradient imposed by their high partitioning coefficients. The addition of a non-aqueous-phase (NAP) with a high affinity for the gas pollutant to packed bed or suspended-growth bioreactor configurations has resulted in enhanced elimination capacities and process robustness. Despite recent research has just added more desired characteristics to the selection criteria of the optimum NAP in gas treatment applications, silicone oil continues being the most popular mass transfer vector. This technology has been successfully applied to the treatment of hexane, methane, styrene, alpha-pinene and BTEX in biofilters, biotrickling filters, stirred tank and airlift bioreactors. The maximum potential of two-phase partitioning bioreactors (TPPBs) during off-gas treatment is achieved when the microbial community is confined inside the NAP. TPPB modeling has also experienced significant advances, the most advanced platforms being able to describe the recent findings in the field. This chapter will compile and critically discuss the fundamentals and most recent breakthroughs in the field of TPPBs for gas treatment applications.
       
  • Innovative non-aqueous phases and partitioning bioreactor configurations
    • Abstract: Publication date: Available online 18 February 2019Source: Advances in Chemical EngineeringAuthor(s): Sonia Arriaga, Aitor AizpuruAbstractSeveral new configurations of Two Phase Partitioning Bioreactors (TPPBs) are presently investigated to improve the manufacture of added value products or the treatment of toxic xenobiotics. As the first determining step in TPPBs systems consists in the selection of the non-aqueous phase (NAP), several neoteric NAPs are currently evaluated (ionic liquids, deep eutectic solvents, supercritical fluids). Additionally, non-aqueous biphasic systems have been recently implemented. Regarding novel configurations, retentive and extractive membrane and enzymatic bioreactors have proven particularly suitable, extending TPPBs domain of application. Finally, innovative mixed systems combining biodegradation with other concurrent or sequential operations (sonication, UV oxidation, CO2 injection, absorption or adsorption) can achieve a more integral process or intensify performance. This chapter illustrates future potential trends in TPPBs applications, presenting non-exhaustive original studies.
       
  • Solid–liquid partitioning bioreactors for industrial wastewater
           treatment
    • Abstract: Publication date: Available online 18 February 2019Source: Advances in Chemical EngineeringAuthor(s): M. Concetta Tomei, Andrew J. DaugulisAbstractIn two-phase solid–liquid partitioning bioreactors (TPPBs), inexpensive and inert commercial polymers are used to replace immiscible organic solvents to absorb and release toxic organic molecules for degradation by mixed populations. In such systems, the polymers act exactly as does an organic solvent, with uptake/release occurring via absorption, and reduced aqueous contaminant levels arising from the maintenance of a thermodynamic equilibrium between the aqueous and polymer phases. The use of commercial, non-volatile, non-flammable, biocompatible and easily-shaped polymers as the sequestering phase is a step forward in the development of “green,” solvent-free bio-treatment strategies. In this chapter, the principle of operation, applications and demonstrated results of solid–liquid TPPBs operated with polymeric sequestering phases are reported for biological industrial wastewater treatment.
       
  • Chapter Three - Spatial Filtering for Scale Bridging and Its Application
           to Transport in Dense Particle Beds
    • Abstract: Publication date: 2018Source: Advances in Chemical Engineering, Volume 53Author(s): Stefan Radl, Federico MunicchiAbstractThe method of spatial filtering as a universal approach to support closure development for models of dense fluid–particle systems is presented. Starting from a set of governing equations, an overview of closures that are required at different levels of a model hierarchy is provided. A focus is on closures to be used in mesoscale models, highlighting recent developments that aim at the description of the variability of exchange coefficients, as well as wall effects. Furthermore, attempts to describe the anisotropy of mesoscale stresses, as well as the effect of cohesive particle–particle interactions in the context of macroscale models are summarized. Computational aspects, together with selected verification cases are documented to stimulate a broader use of the filtering approach. Finally, three future research directions that appear most fruitful are outlined. These final thoughts may help to establish more reliable and robust multiphase flow models for reactive systems.
       
  • Chapter Two - Advances in Coarse Discrete Particle Methods With Industrial
           Applications
    • Abstract: Publication date: 2018Source: Advances in Chemical Engineering, Volume 53Author(s): Liqiang Lu, Sofiane BenyahiaAbstractThis chapter provides the full description of a coarse-grained discrete particle method based on a novel hard-sphere contact model for the simulation of industrial-scale fluidized bed reactors. This method is based on simple models that are easy to understand and implement in numerical codes. This technique is verified and validated for several small-scale fluidized systems where numerical data based on finer methods as well as experimental data are available. The speed of execution of this method is increased several orders of magnitudes compared to particle-based discrete methods, which allows for thousands of seconds of flow, heat, and mass transfer simulations of industrial reactors such as fluidized catalytic cracking regenerator, Methanol to Olefins reactor, and Rare Earth Elements leaching reactor, achieved in just few days using commonly available computer resources. It is now possible for the common engineer to conduct simulations of large-scale fluid–particle reactors to understand, design, and troubleshoot, as well as optimize the performance of these complex multiphase flow systems.
       
  • Chapter One - Multiscale Modelling of Dense Gas–Particle Flows
    • Abstract: Publication date: 2018Source: Advances in Chemical Engineering, Volume 53Author(s): Maike W. Baltussen, Kay A. Buist, Elias A.J.F. Peters, Johannes A.M. KuipersAbstractIn large-scale industrial processes involving granulation, coating, and production of base chemicals and polymers dense particulate flows with coupled mass, momentum, and heat transfer are frequently encountered. Both (effective) fluid–particle and (dissipative) particle–particle interactions need to be accounted for because the mutual competition between these phenomena govern the key features of dense gas–particle flows such as regime transitions. These interactions prevail at different length scales and consequently a multiscale approach is adopted to arrive at a quantitative description of these complex flows. In this approach detailed models, taking into account the relevant details of fluid–particle interaction (DNS) and particle–particle interaction (DEM) are used to obtain closure laws to feed two-fluid models (TFMs) which can be used to simulate the flow on a much larger (industrial) scale. In this chapter, we will discuss recent advances in the multiscale simulation of dense gas-fluidized beds. The governing equations will be presented as well as the key features of the numerical solution method. For each model type, illustrative computational results will be presented. Finally, areas which need substantial further attention will be discussed.
       
  • Series Page
    • Abstract: Publication date: 2018Source: Advances in Chemical Engineering, Volume 53Author(s):
       
 
 
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