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Showing 1 - 200 of 3175 Journals sorted alphabetically
A Practical Logic of Cognitive Systems     Full-text available via subscription   (Followers: 9)
AASRI Procedia     Open Access   (Followers: 14)
Academic Pediatrics     Hybrid Journal   (Followers: 28, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 22, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 90, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 25, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 33, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 5)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 6, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 376, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 2)
Acta Biomaterialia     Hybrid Journal   (Followers: 27, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 2)
Acta de Investigación Psicológica     Open Access   (Followers: 3)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (Followers: 1, SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 235, SJR: 3.683, h-index: 202)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.615, h-index: 21)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 10, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription  
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 2, SJR: 0.311, h-index: 16)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 25, SJR: 1.365, h-index: 73)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.383, h-index: 19)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 1)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 6, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 3, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 6)
Acute Pain     Full-text available via subscription   (Followers: 14)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 7)
Additive Manufacturing     Hybrid Journal   (Followers: 9, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 22)
Advanced Cement Based Materials     Full-text available via subscription   (Followers: 3)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 130, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 16, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 8, SJR: 0.299, h-index: 15)
Advances in Agronomy     Full-text available via subscription   (Followers: 12, SJR: 2.071, h-index: 82)
Advances in Anesthesia     Full-text available via subscription   (Followers: 27, SJR: 0.169, h-index: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 2)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 10, SJR: 1.054, h-index: 35)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 10, SJR: 0.801, h-index: 26)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 22, SJR: 1.286, h-index: 49)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 14, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
Advances in Botanical Research     Full-text available via subscription   (Followers: 2, SJR: 0.619, h-index: 48)
Advances in Cancer Research     Full-text available via subscription   (Followers: 28, SJR: 2.215, h-index: 78)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 7, SJR: 0.9, h-index: 30)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 2.139, h-index: 42)
Advances in Cell Aging and Gerontology     Full-text available via subscription   (Followers: 3)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 27, SJR: 0.183, h-index: 23)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 10, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 19, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 14, SJR: 0.223, h-index: 22)
Advances in Dermatology     Full-text available via subscription   (Followers: 14)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 10)
Advances in Digestive Medicine     Open Access   (Followers: 8)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 21)
Advances in Ecological Research     Full-text available via subscription   (Followers: 42, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 27, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 6)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 42, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 1)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 7)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 54, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 15)
Advances in Genetics     Full-text available via subscription   (Followers: 14, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 7)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 21, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 0.497, h-index: 31)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 23)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 1, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 36, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 2, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 3)
Advances in Life Course Research     Hybrid Journal   (Followers: 8, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Marine Biology     Full-text available via subscription   (Followers: 14, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 21)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 8)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 3)
Advances in Oncobiology     Full-text available via subscription   (Followers: 1)
Advances in Organ Biology     Full-text available via subscription   (Followers: 1)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 6, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 5, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 24, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 10)
Advances in Pharmacology     Full-text available via subscription   (Followers: 15, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 7)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 17)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 18, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 59)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 6, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.1, h-index: 2)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 5)
Advances in Space Research     Full-text available via subscription   (Followers: 374, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 5)
Advances in Surgery     Full-text available via subscription   (Followers: 9, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 29, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 17)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 46, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 6, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 333, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 6, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 9, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 429, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 31, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 43, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access   (Followers: 1)
Agriculture and Natural Resources     Open Access   (Followers: 2)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 56, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 5, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 11, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 9)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access   (Followers: 1)
Algal Research     Partially Free   (Followers: 9, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 5, SJR: 0.776, h-index: 35)
Alpha Omegan     Full-text available via subscription   (SJR: 0.121, h-index: 9)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 9, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 48, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 4)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 4)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 6)
American Heart J.     Hybrid Journal   (Followers: 50, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 50, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 42, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 10, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 31, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 26, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 32, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 42, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 189, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 62, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 6)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 25, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 27, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 27, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 37, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 6)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 61, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 14)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 4, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 39, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 165, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 10, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 11)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 1)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 22, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1)

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Journal Cover Advances in Medical Sciences
  [SJR: 0.489]   [H-I: 25]   [6 followers]  Follow
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 1896-1126 - ISSN (Online) 1898-4002
   Published by Elsevier Homepage  [3175 journals]
  • Urinary exoglycosidases, reference values in healthy children
    • Authors: Beata Zalewska-Szajda; Katarzyna Taranta-Janusz; Sylwia Chojnowska; Napoleon Waszkiewicz; Krzysztof Zwierz; Anna Wasilewska
      Pages: 224 - 229
      Abstract: Publication date: September 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 2
      Author(s): Beata Zalewska-Szajda, Katarzyna Taranta-Janusz, Sylwia Chojnowska, Napoleon Waszkiewicz, Krzysztof Zwierz, Anna Wasilewska
      Purpose The purpose of the study was to determine the effect of age on lysosomal exoglycosidase activities: α-fucosidase, β-galactosidase, β-glucuronidase and α-mannosidase in healthy children and adolescents. Material and methods Urine samples were collected from 203 healthy children and adolescents (girls = 99, boys = 104), aged six months to 17.9 years. The activities of α-fucosidase, β-galactosidase, β-glucuronidase and α-mannosidase were determined by colorimetric method and expressed in pKat/μg of creatine (pKat/μg Cr.). Results Urinary α-fucosidase, β-galactosidase, β-glucuronidase and α-mannosidase activities (pKat/μg Cr.) were the highest in children below 3 years of age in comparison to the remaining age groups. There was a statistically significant negative correlation between urinary α-fucosidase, β-galactosidase, β-glucuronidase and α-mannosidase (pKat/μg Cr.) and age (r = −0.36; r = −0.36; r = −0.35; r = −0.35; at p < 0.0001, respectively). In addition, we constructed the reference values for urinary activity of α-fucosidase, β-galactosidase, β-glucuronidase and α-mannosidase (pKat/μg Cr.) in percentiles according to age in 3-year intervals. Conclusions Our study is the first to show reference values for urinary α-fucosidase, β-galactosidase, β-glucuronidase and α-mannosidase in children and adolescents.

      PubDate: 2018-02-15T08:25:07Z
      DOI: 10.1016/j.advms.2018.01.004
  • Low-dose computed tomography screening reduces lung cancer mortality
    • Authors: Marcin Ostrowski; Tomasz Marjański; Witold Rzyman
      Pages: 230 - 236
      Abstract: Publication date: September 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 2
      Author(s): Marcin Ostrowski, Tomasz Marjański, Witold Rzyman
      Lung cancer causes an estimated 1.6 million deaths each year, being the leading cause of cancer-related deaths in the world. Late diagnosis and, in some cases, the high aggressiveness of the tumour result in low overall five-year survival rates of 12% among men and 7% among women. The cure is most likely in early-stage disease. The poor outcomes of treatment in lung cancer resulting from the fact that most cases are diagnosed in the advanced stage of the disease justify the implementation of an optimal lung cancer prevention in the form of smoking cessation and screening programmes that would offer a chance to detect early stages of the disease, while fitting within specific economic constraints. The National Lung Screening Trial (NLST) – the largest and most expensive randomised, clinical trial in the USA demonstrated a 20% mortality rate reduction in patients who had undergone chest low-dose computed tomography (LDCT) screening, as compared to patients screened with a conventional chest X-ray. Results of the NLST enabled the implementation of lung cancer screening programme among highrisk patients in the USA and parts of China. In 2017, recommendations of the European Society of Thoracic Surgeons also strongly recommend an implementation of a screening programme in the EU. Further studies of improved lung cancer risk assessment scores and of effective molecular markers should intensify in order to reduce all potential harms to the high-risk group and to increase cost-effectiveness of the screening.

      PubDate: 2018-02-15T08:25:07Z
      DOI: 10.1016/j.advms.2017.12.002
  • Do higher cut-off values for tuberculin skin test increase the specificity
           and diagnostic agreement with interferon gamma release assays in
           immunocompromised Bacillus Calmette-Guérin vaccinated patients'
    • Authors: Serhat Erol; Fatma Arslan Ciftci; Aydin Ciledag; Akin Kaya; Ozlem Ozdemir Kumbasar
      Pages: 237 - 241
      Abstract: Publication date: September 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 2
      Author(s): Serhat Erol, Fatma Arslan Ciftci, Aydin Ciledag, Akin Kaya, Ozlem Ozdemir Kumbasar
      Purpose Immunocompromised patients with latent tuberculosis infection (LTBI) are at high risk of progression to active tuberculosis. Detection and treatment of LTBI in this group of patients are very important to control active tuberculosis. Tuberculin skin test (TST) and interferon gamma release assays (IGRAs) are two methods for detection of LTBI. Diagnostic agreement between two tests are poor especially in Bacillus Calmette-Guérin (BCG) vaccinated immunocompromised patients. In this study, we tried to figure out if the use of a higher cut-off for TST increases diagnostic agreement with IGRAs and TST specificity and or not. Materials/Methods In this retrospective study, BCG vaccinated solid organ transplantation (SOT) candidates and patients scheduled for anti-tumor necrosis factor-alpha (anti- TNFα) treatment patients who underwent both TST and IGRAs between 2011 and 2017 were enrolled in the study. Diagnostic agreement between the two tests was assessed for 5, 10, 15 mm cut-off values for all participants, SOT candidates and anti- TNFα treatment subgroups separately. Results Fifty female and 55 male total 105 patients were included. In the anti- TNFα treatment group 92.8% of the patients were receiving at least one immunosuppressive drug. For all participants kappa (κ) values were 0.303, 0.370, 0.321 respectively for 5, 10 and 15 mm cut-offs. For SOT candidates κ values were 0.488, 0.422, 0.288 respectively. For anti- TNFα treatment group κ values were 0.235, 0.332, 0.275 respectively. Conclusions In BCG vaccinated immunocompromised patients, the agreement between TST and QFT-GIT was poor regardless of cut-off value. And increasing the cut-off does not improve agreement.

      PubDate: 2018-03-18T22:56:56Z
      DOI: 10.1016/j.advms.2017.12.001
  • The preliminary association study of ADIPOQ, RBP4, and BCMO1 variants with
           polycystic ovary syndrome and with biochemical characteristics in a cohort
           of Polish women
    • Authors: Ewa Czeczuga-Semeniuk; Marzenna Galar; Katarzyna Jarząbek; Piotr Kozłowski; Nela A. Sarosiek; Sławomir Wołczyński
      Pages: 242 - 248
      Abstract: Publication date: September 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 2
      Author(s): Ewa Czeczuga-Semeniuk, Marzenna Galar, Katarzyna Jarząbek, Piotr Kozłowski, Nela A. Sarosiek, Sławomir Wołczyński
      Purpose We aimed to elucidate the frequency of the SNPs in the ADIPOQ, RBP4 and BCMO1genes in a population of Caucasian Polish women with polycystic ovary syndrome (PCOS), and to evaluate the possible associations between these variants and the susceptibility to PCOS. Additionally, the relationship of these polymorphisms to a clinical phenotype of this syndrome, and the concentrations of adipokines, were determined. Materials/methods Clinical and biochemical profiles, DNA isolation and genotyping, and adipokine assays were performed in 294 PCOS women and 78 controls. Results In a cohort of Polish women, for the genotype distribution and allele frequencies (minor allele frequency − MAF) proved that only the SNP rs1501299 in the gene ADIPOQ (P = 0.0010, OR = 0.41, 95% C.I.:0.24-0.70) and rs7501331 in the gene BCMO1 (P = 0.0106, OR = 0.24, 95% C.I.:0.21-0.71), are significantly associated (the latter marginally significant) with the decrease of the risk of the disease. Also for this SNPs there were significant differences in the genotypic frequencies in the study population. There was a link between rs12934922 of BCMO1 gen and serum concentration of RBP4 (P = 0.034) and adiponectin (P = 0.038) in the study group but not in the control group. The elevated mean serum concentration of cholesterol (P = 0.020) and LDL cholesterol (P = 0.005) was observed for GG rs1501299 genotype and triglycerides (P = 0.028) for TT rs2241766 genotype. Conclusions The results of the present study revealed that the genes variants RBP4 is not associated with PCO. It seems that rs1501299 of ADIPOQ gene influences the occurrence of PCO and lipids profile in those patients.

      PubDate: 2018-03-18T22:56:56Z
      DOI: 10.1016/j.advms.2018.01.002
  • A simplified approach for evaluating sustained slow pathway conduction for
           diagnosis and treatment of atrioventricular nodal reentry tachycardia in
           children and adults
    • Authors: Janusz Sledz; Michal Labus; Mariusz Mazij; Monika Klank-Szafran; Dariusz Karbarz; Bartosz Ludwik; Jacek Kusa; Karol Deutsch; Leslaw Szydlowski; Adrian Mscisz; Jerzy Spikowski; Aleksandra Morka; Tomasz Kameczura; Aleksandra Swietoniowska; Sebastian Stec
      Pages: 249 - 256
      Abstract: Publication date: September 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 2
      Author(s): Janusz Sledz, Michal Labus, Mariusz Mazij, Monika Klank-Szafran, Dariusz Karbarz, Bartosz Ludwik, Jacek Kusa, Karol Deutsch, Leslaw Szydlowski, Adrian Mscisz, Jerzy Spikowski, Aleksandra Morka, Tomasz Kameczura, Aleksandra Swietoniowska, Sebastian Stec
      Purpose During incremental atrial pacing in patients with atrioventricular nodal reentrant tachycardia, the PR interval often exceeds the RR interval (PR > RR) during stable 1:1 AV conduction. However, the PR/RR ratio has never been evaluated in a large group of patients with pacing from the proximal coronary sinus and after isoproterenol challenge. Our study validates new site of pacing and easier method of identification of PR > RR. Material and methods A prospective protocol of incremental atrial pacing from the proximal coronary sinus was carried out in 398 patients (AVNRT-228 and control-170). The maximum stimulus to the Q wave interval (S-Q = PR), SS interval (S-S), and Q-Q (RR) interval were measured at baseline and 10 min after successful slow pathway ablation and after isoproterenol challenge (obligatory). Results The mean maximum PR/RR ratios at baseline were 1.17 ± 0.24 and 0.82 ± 0.13 (p < 0.00001) in the AVNRT and controls respectively. There were no PR/RR ratios ≥1 at baseline and after isoproterenol challenge in 12.3% of the AVNRT group and in 95.9% of the control group (p < 0.0001). PR/RR ratios ≥1 were absent in 98% of AVNRT cases after slow pathway ablation/modification in children and 99% of such cases in adults (P = NS). The diagnostic performance of PR/RR ratio evaluation before and after isoproterenol challenge had the highest diagnostic performance for AVNRT with PR/RR > = 1 (sensitivity: 88%, specificity: 96%, PPV-97%, NPV-85%). Conclusions The PR/RR ratio is a simple tool for slow pathway substrate and AVNRT evaluation. Eliminating PR/RR ratios ≥1 may serve as a surrogate endpoint for slow pathway ablation in children and adults with AVNRT.

      PubDate: 2018-02-15T08:25:07Z
      DOI: 10.1016/j.advms.2018.01.001
  • Aspartic acid functionalized PEGylated MSN@GO hybrid as an effective and
           sustainable nano-system for in-vitro drug delivery
    • Authors: Reza Rahmatolahzadeh; Masood Hamadanian; Leila Ma’mani; Abbas Shafiee
      Pages: 257 - 264
      Abstract: Publication date: September 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 2
      Author(s): Reza Rahmatolahzadeh, Masood Hamadanian, Leila Ma’mani, Abbas Shafiee
      Purpose In this research, aspartic acid functionalized PEGylated mesoporous silica nanoparticlesgraphene oxide nanohybrid (As-PEGylated-MSN@GO) prepared as a pH-responsive drug carrier for the curcumin delivery. For better camouflage during blood circulation, poly(ethylene glycol) was decorated on the surface of MSN@GO nanohybrid. Materials and methods The nanocarrier was characterized by using X-ray powder diffraction (XRD), dynamic light scattering (DLS), UV–vis spectroscopy, thermal gravimetry analysis (TGA), FT-IR, SEM and TEM. Results The size of modified MSN@GO was around 75.8 nm and 24% wt. of curcumin was loaded on the final nanohybrid. pHdecrement from 7.4 to 5.8 the release medium led to increase the cumulative amount of drug release from 54% to 98%. Conclusions As-functionalized MSN@GO had no cytotoxicity against human breast adenocarcinoma (MCF-7) and human mammary epithelial (MCF10A) as cancerous and normal cell lines, respectively. Whereas curcuminloaded nanohybrid showed excellent killing capability against MCF-7 cells.

      PubDate: 2018-04-15T13:58:06Z
      DOI: 10.1016/j.advms.2018.01.003
  • Markers of anaphylaxis – a systematic review
    • Authors: Maria Magdalena Tomasiak-Łozowska; Maciej Klimek; Agnieszka Lis; Marcin Moniuszko; Anna Bodzenta-Łukaszyk
      Pages: 265 - 277
      Abstract: Publication date: September 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 2
      Author(s): Maria Magdalena Tomasiak-Łozowska, Maciej Klimek, Agnieszka Lis, Marcin Moniuszko, Anna Bodzenta-Łukaszyk
      Anaphylaxis is defined as severe, life-threatening, systemic or general, immediate reaction of hypersensitivity, with repeatable symptoms caused by the dose of stimulus which is well tolerated by healthy persons. The proper diagnosis, immediate treatment and differential diagnosis are crucial for saving patient's life. However, anaphylaxis is relatively frequently misdiagnosed or confused with other clinical entities. Thus, there is a continuous need for identifying detectable markers improving the proper diagnosis of anaphylaxis. Here we presented currently known markers of anaphylaxis and discussed in more detail the most clinically valuable ones: tryptase, platelet activacting factor (PAF), PAF-acethylhydrolase, histamine and its metabolites.

      PubDate: 2018-04-15T13:58:06Z
      DOI: 10.1016/j.advms.2017.12.003
  • Th9 lymphocytes and functions of interleukin 9 with the focus on IBD
    • Authors: Krzysztof Matusiewicz; Barbara Iwańczak; Małgorzata Matusiewicz
      Pages: 278 - 284
      Abstract: Publication date: September 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 2
      Author(s): Krzysztof Matusiewicz, Barbara Iwańczak, Małgorzata Matusiewicz
      The work presents the newest knowledge on a new phenotype of T helper lymphocytes (Th9) and on Interleukin 9 (IL-9). Processes leading to transformation of naïve T lymphocyte into Th9 lymphocytes are presented, including the role of IL-4 and TGFβ signaling. Involvement of transcription factor network in production of IL-9 is described. Other cells capable of expressing IL-9 and secreting IL-9 are portrayed. Diversity of IL-9 effects caused by activation of IL-9 receptors on various types of cells is presented. Principal effects of the activation of IL-9 receptor on T-cells seem to be antiapoptotic and stimulatory which leads to enhanced defense against parasitic infection and cancer development but, from the other side, it perpetuate chronic inflammation in autoimmune diseases and allergic processes. In the last years the role of IL-9 in autoimmune diseases such as rheumatic diseases and inflammatory bowel disease gained importance since the increased expression of this cytokine has been observed in animal models of intestinal inflammation and in groups of patients with ulcerative colitis. It was also noted that neutralization of IL-9 in animal models of ulcerative colitis leads to amelioration of inflammatory process, what could have significance in the treatment of this disease in humans in the future.

      PubDate: 2018-04-15T13:58:06Z
      DOI: 10.1016/j.advms.2018.03.002
  • Interactions between the growth hormone and cytokines – A review
    • Authors: Mieczysław Szalecki; Anna Malinowska; Monika Prokop-Piotrkowska; Roman Janas
      Pages: 285 - 289
      Abstract: Publication date: September 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 2
      Author(s): Mieczysław Szalecki, Anna Malinowska, Monika Prokop-Piotrkowska, Roman Janas
      Numerous reports on the interactions between the immune and endocrine systems, especially growth hormone axis, can be found in the literature. Growth hormone acts mainly indirectly through insulin-like growth factor-1, which stimulates the growth and development processes, metabolism of lipids, proteins, and carbohydrates, and it also has a modulating effect on the cells of the immune system. Several studies have been conducted on the influence of growth hormone therapy on the immunological parameters in children and adults with and without growth hormone deficiency. However, there have been no definite results and some of them have been even contradictory. Some studies have suggested that administration of growth hormone increases the production of tumor necrosis factor and certain pro- and anti-inflammatory cytokines; whereas other studies have demonstrated the lack of correlation between growth hormone and interleukins. The aim of this paper was to evaluate the available literature on the interaction between growth hormone and TNF-α, pro-inflammatory (IL-1β, IL-2, IL-6) and anti-inflammatory (IL-4, IL-10) interleukins.

      PubDate: 2018-04-15T13:58:06Z
      DOI: 10.1016/j.advms.2018.03.001
  • Activation of mitochondrial KATP channels mediates neuroprotection induced
           by chronic morphine preconditioning in hippocampal CA-1 neurons following
           cerebral ischemia
    • Authors: Maedeh Arabian; Nahid Aboutaleb; Mansoureh Soleimani; Marjan Ajami; Rouhollah Habibey; Hamidreza Pazoki-Toroudi
      Pages: 213 - 219
      Abstract: Publication date: September 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 2
      Author(s): Maedeh Arabian, Nahid Aboutaleb, Mansoureh Soleimani, Marjan Ajami, Rouhollah Habibey, Hamidreza Pazoki-Toroudi
      Purpose Pharmacologic preconditioning, through activating several mechanisms and mediators, can increase the tolerance of different tissues against ischemia/reperfusion (I/R) injury. Recent studies have shown that morphine preconditioning has protective effects in different organs, especially in the heart. Nevertheless, its mechanisms are not well elucidated in the brain. The present study aimed to clarify whether the activation of mitochondrial KATP (mKATP) channels in chronic morphine (CM) preconditioning could decrease hippocampus damage following I/R injury. Materials and methods CM preconditioning was performed by the administration of additive doses of morphine for 5days before I/R injury induction. I/R injury was induced by the occlusion of bilateral common carotid arteries. The possible role of mKATP channels was evaluated by the injection of 5-hydroxydecanoate (5-HD) before I/R injury. Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) was performed to detect apoptosis in hippocampal neurons. The expressions of B-cell lymphoma-2 (Bcl-2) and Bcl-2-associated X protein (BAX) and levels of malondialdehyde (MDA) and catalase (CAT) enzymes were assessed. Results CM attenuated apoptosis in the hippocampal CA1 neurons (P < 0.001 vs I/R), and mKATP channel blocking with 5-HD significantly increased apoptosis (P < 0.001 vs CM+I/R). CM increased CAT activity (P< 0.05 vs I/R) and Bcl-2 protein expression (P< 0.01 vs I/R), while it decreased MDA level (P< 0.05 vs I/R) and BAX protein expression (P< 0.05 vs I/R). Pretreatment with 5-HD abolished all the above-mentioned effects of CM. Conclusions These findings describe novel evidence whereby CM preconditioning in hippocampal CA1 neurons can improve oxidative stress and apoptosis through the activation of mKATP channels and eventually protect the hippocampal tissue against I/R injury.
      Graphical abstract image

      PubDate: 2017-12-11T16:10:26Z
      DOI: 10.1016/j.advms.2017.11.003
  • TGF-β and inflammatory blood markers in prediction of intraperitoneal
    • Authors: Kamil Torres; Łukasz Pietrzyk; Zbigniew Plewa; Karolina Załuska-Patel; Mariusz Majewski; Elżbieta Radzikowska; Anna Torres
      Pages: 220 - 223
      Abstract: Publication date: September 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 2
      Author(s): Kamil Torres, Łukasz Pietrzyk, Zbigniew Plewa, Karolina Załuska-Patel, Mariusz Majewski, Elżbieta Radzikowska, Anna Torres
      Purpose Intraperitoneal adhesions (IA) develop as a consequence of the healing process in peritoneum injured during surgeries. IA might be formed after all types of surgical interventions regardless the surgical approach with a higher incidence in obese individuals. Here we determine the diagnostic power of TGF-β and blood inflammatory parameters in the prediction of IA in obese patients undergoing second surgical intervention. Materials and methods Eighty patients were divided into groups according to body mass index (BMI) values and presence of intraperitoneal adhesions (IA). Evaluation of peritoneal adhesion index (PAI), serum TGF-β and blood inflammatory parameters was performed. Results Level of TGF-β, C-reactive protein (CRP), leukocytes, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio were significantly higher in obese patients while TGF-β, CRP, and leukocytes were higher in patients with IA. There was a significant correlation between PAI values and TGF-β concentration (p<0.001; r=0.869) in IA group. Conclusions The preoperative TGF-β concentration, BMI, CRP and NLR could be strong predictors of intraperitoneal adhesions in patients with the history of surgeries.

      PubDate: 2017-12-11T16:10:26Z
      DOI: 10.1016/j.advms.2017.11.006
  • The alterations in alcohol dehydrogenase and aldehyde dehydrogenase
           activities in the sera of patients with renal cell carcinoma
    • Authors: Karolina Orywal; Wojciech Jelski; Tadeusz Werel; Maciej Szmitkowski
      Pages: 1 - 4
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Karolina Orywal, Wojciech Jelski, Tadeusz Werel, Maciej Szmitkowski
      Purpose In a previous study we showed that the total activity of alcohol dehydrogenase (ADH) and its isoenzyme class I was significantly higher in renal cancer (RCC) cells compared to normal kidney. The aim of this study was to compare the activities of ADH isoenzymes and aldehyde dehydrogenase (ALDH) in the sera of patients with different stages of RCC and healthy subjects. Materials and methods Serum samples were taken from 54 patients with clear cell RCC (17 patients in stage II, 22 in stage III and 15 in stage IV) and 52 healthy patients. Class III, IV of ADH and the total ADH activity was measured by the photometric method. For the measurement of ADH class I, II and the total ALDH activity we employed the fluorometric method. Results The total activity of ADH and its isoenzyme class I were significantly higher in the sera of patients with every stage of RCC compared to healthy subjects. The analysis of ALDH activity did not indicate significant differences between tested groups. Conclusions The increased activity of total ADH and its isoenzyme class I in the sera of patients with RCC, seems to be caused by isoenzymes being released from cancerous cells and may be useful for diagnostics of renal cancer.

      PubDate: 2017-08-06T13:01:40Z
      DOI: 10.1016/j.advms.2017.05.001
  • Impact of intervention on metabolic outcomes among dropouts with type 2
    • Authors: Merja K. Laine; Timo Kauppila; Mikko Honkasalo; Marko Raina; Johan G. Eriksson
      Pages: 5 - 8
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Merja K. Laine, Timo Kauppila, Mikko Honkasalo, Marko Raina, Johan G. Eriksson
      Purpose The aim of this study was to evaluate the effect of an individual intervention given by health care professionals to dropouts with type 2 diabetes (T2D) on their metabolic profile. Materials/methods In 2010, we identified 356 T2D dropouts in Vantaa Health Centre, Finland. At the baseline visit the participants’ status was assessed including laboratory tests. Diabetes counseling was given, and drug treatment was enhanced when needed. The follow-up visit was performed 13 to 30 months later including the same assessments as performed at the baseline visit. The dropouts who attended the follow-up visit formed the study group. One third (n=115) of the dropouts participated in the follow-up visit. Results The study participants (mean age 61.4 years) were older than the non-participants (mean age 58.5 years) (p=0.009). After the intervention the proportion of participants with hemoglobin A1c≥9% (75mmol/mol) decreased from 15.5% to 5.2% (p=0.004). Improvements were also observed in general in hemoglobin A1c, from 6.6% (49mmol/mol) to 6.3% (45mmol/mol) (p=0.001), in total cholesterol, from 4.9mmol/l to 4.5mmol/l (p=0.011), in low-density lipoprotein cholesterol, from 2.9mmol/l to 2.6mmol/l (p=0.015) and in diastolic blood pressure, from 90mmHg to 84mmHg (p=0.001). Conclusions Dropouts with T2D were difficult to bring back to the public health care system, especially men under the age of 60 years. Dropouts who participated in the intervention showed improvements in several metabolic outcomes.

      PubDate: 2017-08-06T13:01:40Z
      DOI: 10.1016/j.advms.2017.05.003
  • Genetic basis of enzymatic resistance of E. coli to aminoglycosides
    • Authors: Dominika Ojdana; Anna Sieńko; Paweł Sacha; Piotr Majewski; Piotr Wieczorek; Anna Wieczorek; Elżbieta Tryniszewska
      Pages: 9 - 13
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Dominika Ojdana, Anna Sieńko, Paweł Sacha, Piotr Majewski, Piotr Wieczorek, Anna Wieczorek, Elżbieta Tryniszewska
      Purpose Over the past years, an increase in resistance to aminoglycosides has been observed among Enterobacteriaceae rods. This resistance development reduces therapeutic options for infections caused by multidrug-resistance organisms. Because of the changing epidemiology of extended-spectrum β-lactamases (ESBLs) and resistance to aminoglycosides, we investigated the prevalence of the aac(3)-Ia, aac(6′)-Ib, ant(4′)-IIa, ant(2”)-Ia, and aph(3”)-Ib genes encoding aminoglycoside-modifying enzymes (AMEs) in ESBL-producing Escherichia coli as well as ESBL-non-producing isolates. To understand bacterial resistance to aminoglycoside antibiotics, we estimated resistance phenotypes and the presence of genes responsible for this resistance. Materials and methods The study was conducted on 44 E.coli strains originated from patients hospitalized at University Hospital of Bialystok. MIC values were obtained for gentamicin, amikacin, netilmicin, and tobramycin. Isolates were tested for the presence of the aac(3)-Ia, aac(6′)-Ib, ant(4′)-IIa, ant(2”)-Ia, and aph(3”)-Ib genes with the use of the PCR technique. Results Resistance to aminoglycosides was found in 79.5% of the isolates. The highest percentages of resistance were observed for tobramycin (70,5%) and gentamicin (59%), followed by netilmicin (43.2%) and amikacin (11.4%). PCR assays revealed the presence of aac(6′)-Ib among 26 (59.2%) strains, aph(3”)-Ib among 16 (36.2%), aac(3)-Ia among 7 (15.9%), and ant(2”)-Ia among 2 (4.6%) strains. Conclusions The enzymatic resistance against aminoglycosides in northeastern Poland among clinical isolates of E. coli is predominantly caused by aac(6′)-Ib and aph(3”)-Ib. Amikacin may be used for therapy of infections caused by ESBL-producing E. coli, because of the low rates of resistance.

      PubDate: 2017-08-06T13:01:40Z
      DOI: 10.1016/j.advms.2017.05.004
  • Cytotoxic, genotoxic and antimicrobial activity of caffeic and rosmarinic
           acids and their lithium, sodium and potassium salts as potential
           anticancer compounds
    • Authors: Marzena Matejczyk; Renata Świsłocka; Aleksandra Golonko; Włodzimierz Lewandowski; Eliza Hawrylik
      Pages: 14 - 21
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Marzena Matejczyk, Renata Świsłocka, Aleksandra Golonko, Włodzimierz Lewandowski, Eliza Hawrylik
      Purpose The aim of this study was to examine the cytotoxic, genotoxic, antioxidant and antimicrobial activity of caffeic and rosmarinic acids and their salts with Li, Na and K with use of Escherichia coli K-12 recA:gfp strain as a model organism. Methods Cytotoxic potency of tested chemicals were calculated on the basis on the dose that confers inhibition percentage such as 20% for each concentrations of analysed chemicals. Genotoxic properties were calculated on the basis of the fold increase (FI) of SFI values normalized with control. Antioxidant potencies were established on the base of DPPH assay. Antimicrobial activity of chemicals were established on the value of minimal inhibitory concentration (MIC). Results Obtained results indicated that lower concentrations of tested compounds exhibited stronger GFP fluorescence response after rosmarinic acids and their salts treatment. Genotoxic effects seemed to be independent of the salt ions. The caffeic acid salts with Li, Na and K showed reduced genotoxic effect in comparison to the caffeic acid while increased cytotoxic effect than that of caffeic acid. Moreover, caffeinate salts exhibited better antimicrobial activity against E. coli (MIC=250μg/mL) than K caffeinate salt (MIC>500μg/mL). The MIC values of Li, Na and K rosmarinate salts were above 500μg/mL against all tested microorganisms. Conclusion The results of the experiment show that there is no clear positive correlation between the antioxidant potency of caffeic and rosmarinic acids and their Li, Na and K salts and their cytotoxic effect. Used salts ions Li, Na and K do not significantly affect the antioxidant effect of natural phenolic compounds and they do not have a significant impact on the biological parameters such as cyto- and genotoxicity. Perhaps it is connected with the reaction environment including polarity of the solvent (water).
      Graphical abstract image

      PubDate: 2017-12-11T16:10:26Z
      DOI: 10.1016/j.advms.2017.07.003
  • A systematic review on the role of eicosanoid pathways in rheumatoid
    • Authors: Malvina Hoxha
      Pages: 22 - 29
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Malvina Hoxha
      Background Rheumatoid arthritis is characterized by the production of eicosanoids, cytokines, adhesion molecules, infiltration of T and B lymphocytes in the synovium and oxygen reduction accompanied by the cartilage degradation. Eicosanoids are responsible for the progressive destruction of cartilage and bone, however neither steroids, nor the non steroidal anti-inflammatory drugs (NSAIDs), cannot slow down cartilage and bone destruction providing only symptomatic improvement. The current rheumatoid arthritis treatment options include mainly the use of disease-modifying anti-rheumatic drugs, the corticosteroids, the NSAIDs and biological agents. Methods PubMed, Cochrane, and Embase electronic database were used as the main sources for extracting several articles, reviews, original papers in English for further review and analysis on the implication of arachidonic acid metabolites with rheumatoid arthritis and different strategies of targeting arachidonic acid metabolites, different enzymes or receptors for improving the treatment of rheumatoid arthritis patients. Results We first focused on the role of individual prostaglandins and leukotrienes, in the inflammatory process of arthritis, concluding with an outline of the current clinical situation of rheumatoid arthritis and novel treatment strategies targeting the arachidonic acid pathway. Conclusions Extended research is necessary for the development of these novel compounds targeting the eicosanoid pathway, by increasing the levels of anti-inflammatory eicosanoids (PGD2,15dPGJ2), by inhibiting the production of pro-inflammatory eicosanoids (PGE2, LTB4, PGI2) involved in rheumatoid arthritis or also by developing dual compounds displaying both the COX-2 inhibitor/TP antagonist activity within a single compound.

      PubDate: 2017-08-27T21:15:05Z
      DOI: 10.1016/j.advms.2017.06.004
  • Patients with atrial fibrillation and coronary artery disease –
           Double trouble
    • Authors: Ewelina Michniewicz; Elżbieta Mlodawska; Paulina Lopatowska; Anna Tomaszuk-Kazberuk; Jolanta Malyszko
      Pages: 30 - 35
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Ewelina Michniewicz, Elżbieta Mlodawska, Paulina Lopatowska, Anna Tomaszuk-Kazberuk, Jolanta Malyszko
      Coronary artery disease (CAD) is the most common cardiovascular disease while atrial fibrillation (AF) is the most common cardiac arrhythmia. Both diseases share associated risk factors – hypertension, diabetes mellitus, sleep apnea, obesity and smoking. Moreover, inflammation plays a causative role in both diseases. The prevalence of CAD in patients with AF is from 17% to 46.5% while the prevalence of AF among patients with CAD is low and it is estimated from 0.2% to 5%. AF is a well-established factor of poor short- and long-term prognosis in patients with acute myocardial infarction (AMI) and is associated with a marked increase in overall mortality. The arrhythmia is common after cardiac surgeries and occurs in about 20 to 40% of patients after coronary artery bypass graft (CABG) surgery. It is predicted that between 5 and 15% of AF patients will require stenting at some point in their lives and will receive triple therapy with aspirin, clopidogrel or ticagrelor and oral anticoagulation (OAC). This requires careful consideration of antithrombotic therapy, balancing bleeding risk, stroke risk, and in-stent thrombosis with subsequent acute coronary syndromes. Co-prescription of OAC with antiplatelet therapy, in particular triple therapy, increases the absolute risk of major bleeding. In addition, major bleeding is associated with an up to 5-fold increased risk of death following an acute coronary syndrome. Coexistence of AF and CAD worsens the prognosis even in carefully treated patients.

      PubDate: 2017-08-27T21:15:05Z
      DOI: 10.1016/j.advms.2017.06.005
  • Antidepressant-like activity of methyl jasmonate involves modulation of
           monoaminergic pathways in mice
    • Authors: Solomon Umukoro; Adaeze Adebesin; Gladys Agu; Osarume Omorogbe; Stephen Babajide Asehinde
      Pages: 36 - 42
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Solomon Umukoro, Adaeze Adebesin, Gladys Agu, Osarume Omorogbe, Stephen Babajide Asehinde
      Purpose The efficacy of current antidepressant drugs has been compromised by adverse effects, low remission and delay onset of action necessitating the search for alternative agents. Methyl jasmonate (MJ), a bioactive compound isolated from Jasminum grandiflorum has been shown to demonstrate antidepressant activity but its mechanism of action remains unknown. Thus, the role of monoaminergic systems in the antidepression-like activity of MJ was investigated in this study. Materials and methods Mice were given i.p. injection of MJ (5, 10 and 20mg/kg), imipramine (10mg/kg) and vehicle (10mL/kg) 30min before the forced swim test (FST) and tail suspension test (TST) were carried out. The involvement of monoaminergic systems in the anti-depressant-like effect of MJ (20mg/kg) was evaluated using p-chlorophenylalanine (pCPA), metergoline, yohimbine, prazosin, sulpiride and haloperidol in the TST. Results MJ significantly decrease the duration of immobility in the FST and TST relative to control suggesting antidepressant-like property. However, pretreatment with yohimbine (1mg/kg, i.p., an α2-adrenergic receptor antagonist) or prazosin (62.5μg/kg, i.p., an α1-adrenoceptor antagonist) attenuated the antidepressant-like activity of MJ. Also, pCPA; an inhibitor of serotonin biosynthesis (100mg/kg, i.p) or metergoline (4mg/kg, i.p., 5-HT2 receptor antagonist) reversed the anti-immobility effect of MJ. Sulpiride (50mg/kg, i.p., a D2 receptor antagonist) or haloperidol (0.2mg/kg, i.p., a dopamine receptor antagonist) reversed the anti-immobility effect of MJ. Conclusion The results of this study suggest that serotonergic, noradrenergic and dopaminergic systems may play a role in the antidepressant-like activity of MJ.

      PubDate: 2017-08-27T21:15:05Z
      DOI: 10.1016/j.advms.2017.07.005
  • Association of Brain-derived neurotrophic factor gene polymorphisms with
           body mass index: A systematic review and meta-analysis
    • Authors: Shahab-Aldin Akbarian; Amin Salehi-Abargouei; Makan Pourmasoumi; Roya Kelishadi; Parvaneh Nikpour; Motahar Heidari-Beni
      Pages: 43 - 56
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Shahab-Aldin Akbarian, Amin Salehi-Abargouei, Makan Pourmasoumi, Roya Kelishadi, Parvaneh Nikpour, Motahar Heidari-Beni
      Background Many studies with inconsistent results have assessed the association of Brain-derived neurotrophic factor (BDNF) gene polymorphisms with prevalence of obesity and overweight. This review aims to provide a summary of the literature evaluating the relation between BDNF genotype and body mass index (BMI). Methods A systematic search through PubMed, Scopus, Science direct, Ovid and Cochrane was performed. We included observational studies with cross-sectional and case-control design, which investigated relationship between all kinds of BDNF polymorphisms with BMI, as a representative index of obesity and overweight. Newcastle–Ottawa Scale was used to assess the quality of included articles. Results Thirty five studies were included in quantitative synthesis. Analyses were performed separately using OR, β coefficient and mean. Significant association were documented between rs925946 and BMI (OR=1.12, 95% CI=1.08–1.17, P heterogeneity=0.317), rs10501087 and BMI (OR=1.14, 95% CI=1.04–1.24, P heterogeneity=0.861), rs6265 and BMI (OR=1.13, 95% CI=1.07–1.19, P heterogeneity=0.406), rs988712 and BMI (OR=1.29, 95% CI=1.18–1.40, P heterogeneity=0.602). According to pooled β coefficient analysis, significant result was only observed in the rs925946 polymorphism subgroup. Pooled mean analysis showed that overall effects for the association between BDNF polymorphisms and BMI were not statistically significant. Conclusion This meta-analysis suggests that some polymorphisms in BDNF gene including rs925946, rs10501087, rs6265 and rs988712 can be considered as genetic determinants of obesity.

      PubDate: 2017-12-11T16:10:26Z
      DOI: 10.1016/j.advms.2017.07.002
  • Trimethylamine-N-oxide, as a risk factor for atherosclerosis, induces
           stress in J774A.1 murine macrophages
    • Authors: Abbas Mohammadi; Zakaria Vahabzadeh; Soran Jamalzadeh; Tahereh Khalili
      Pages: 57 - 63
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Abbas Mohammadi, Zakaria Vahabzadeh, Soran Jamalzadeh, Tahereh Khalili
      Purpose Trimethylamine N-oxide (TMAO) is a biomarker for kidney problems. It has also been introduced as a risk factor for atherosclerosis. The classic risk factors for atherosclerosis trigger cellular and humeral immunoreaction in macrophages through induction of heat shock protein expressions and increased levels of GRP94 and HSP70 are associated with increased atherosclerosis risk. The present study evaluated the possible effect(s) of TMAO on the expression of GRP94 and HSP70 at protein levels. Methods J774A.1 murine macrophages were treated with different micromolar concentrations of TMAO and 4-phenylbutyric acid (PBA), a chemical chaperone, for 8, 18, 24, and 48h intervals. Tunicamycin was also used as a control for induction of endoplasmic reticulum stress. Western blotting was used to evaluate the expression of GRP94 and HSP70 in macrophages at protein levels. Result Tunicamycin greatly increased protein levels of GRP94. Similarly, but to a lesser extent compared to tunicamycin, TMAO also increased GRP94. In 24h treated cells, only 300μM of TMAO, and in cells treated for 48h, all doses of TMAO produced a significant increase in relative HSP70 protein levels compared to the control. PBA failed to induce any changes in GRP94 or HSP70 protein levels. Conclusion GRP94 and HSP70 are stress-inducible heat shock protein, so the elevation in J774A.1 murine macrophages can clearly define cells under stress and elucidate the contribution of stress induced by TMAO that may have a part in the abnormal activation of macrophages involved in foam cell formation.

      PubDate: 2017-08-27T21:15:05Z
      DOI: 10.1016/j.advms.2017.06.006
  • The influence of low level laser irradiation on vascular reactivity
    • Authors: Magdelena Mackiewicz-Milewska; Elżbieta Grześk; Andrzej C. Kroszczyński; Małgorzata Cisowska-Adamiak; Hanna Mackiewicz-Nartowicz; Lilianna Baran; Iwona Szymkuć-Bukowska; Michał Wiciński; Wojciech Hagner; Grzegorz Grześk
      Pages: 64 - 67
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Magdelena Mackiewicz-Milewska, Elżbieta Grześk, Andrzej C. Kroszczyński, Małgorzata Cisowska-Adamiak, Hanna Mackiewicz-Nartowicz, Lilianna Baran, Iwona Szymkuć-Bukowska, Michał Wiciński, Wojciech Hagner, Grzegorz Grześk
      Introduction The mechanism of action of low level laser irradiationon on tissues is unclear.
      Authors of publications present the positive clinical impact of low and medium power laser irradiation on vascular reactivity

      PubDate: 2017-08-27T21:15:05Z
      DOI: 10.1016/j.advms.2017.06.002
  • Endogenous non-enzymatic antioxidants in the human body
    • Authors: Iwona Mirończuk-Chodakowska; Anna Maria Witkowska; Małgorzata Elżbieta Zujko
      Pages: 68 - 78
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Iwona Mirończuk-Chodakowska, Anna Maria Witkowska, Małgorzata Elżbieta Zujko
      The exposure of cells, tissues and extracellular matrix to harmful reactive species causes a cascade of reactions and induces activation of multiple internal defence mechanisms (enzymatic or non-enzymatic) that provide removal of reactive species and their derivatives. The non-enzymatic antioxidants are represented by molecules characterized by the ability to rapidly inactivate radicals and oxidants. This paper focuses on the major intrinsic non-enzymatic antioxidants, including metal binding proteins (MBPs), glutathione (GSH), uric acid (UA), melatonin (MEL), bilirubin (BIL) and polyamines (PAs).

      PubDate: 2017-08-27T21:15:05Z
      DOI: 10.1016/j.advms.2017.05.005
  • A similar pro/anti-inflammatory cytokine balance is present in the airways
           of competitive athletes and non-exercising asthmatics
    • Authors: Marcin Kurowski; Janusz Jurczyk; Agnieszka Olszewska-Ziąber; Marzanna Jarzębska; Hubert Krysztofiak; Marek L. Kowalski
      Pages: 79 - 86
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Marcin Kurowski, Janusz Jurczyk, Agnieszka Olszewska-Ziąber, Marzanna Jarzębska, Hubert Krysztofiak, Marek L. Kowalski
      Purpose Intensive exercise modifies airway inflammation and infection susceptibility. We aimed to determine the effect of exercise on pro- and anti-inflammatory cytokine (TNF-α, IL-1ra, IL-10) and innate immunity protein (HSPA1, sCD14) levels in exhaled breath condensate (EBC) and nasal secretions of competitive athletes, non-exercising asthmatics and healthy controls (HC). Material and methods The study group consisted of 15 competitive athletes (five speed skaters and ten swimmers) aged 15–25. The control groups comprised 10 mild-to-moderate asthmatics (AC) and seven HC. Athletes were assessed in- and off-training while asthmatics and controls at one time point. Nasal lavages and EBC were collected before and after a treadmill exercise challenge. Protein levels were assessed using ELISA. Results TNF-α levels in EBC were significantly higher in athletes than HC, but similar to asthmatic patients. In contrast, IL-1ra EBC concentrations were significantly lower in athletes than in HC, but again similar to asthmatics. Significant positive correlations were seen between baseline concentrations of TNF-α in EBC and fall in FEV1 following exercise challenge in athletes during training period (R=0.74, p<0.01) and in asthmatics (R=0.64, p<0.05). In nasal secretions, baseline IL-1ra levels were significantly higher in athletes and asthmatics than in HC. Exercise caused a slight, yet significant, increase in EBC HSPA1 in athletes (p=0.02). The exercise challenge did not considerably influence TNF-α, IL-1ra, HSPA1 and sCD14 in EBC or nasal secretions. Conclusions Dysregulation of the TNF-α/IL-1ra balance in EBC and nasal secretions from athletes may reflect the presence of airway inflammation induced by repeated strenuous exercise.

      PubDate: 2017-08-27T21:15:05Z
      DOI: 10.1016/j.advms.2017.07.004
  • Novel mutations and their genotype-phenotype correlations in patients with
           Noonan syndrome, using next-generation sequencing
    • Authors: Alireza Tafazoli; Peyman Eshraghi; Francesca Pantaleoni; Rahim Vakili; Morteza Moghaddassian; Martha Ghahraman; Valentina Muto; Stefano Paolacci; Fatemeh Fardi Golyan; Mohammad Reza Abbaszadegan
      Pages: 87 - 93
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Alireza Tafazoli, Peyman Eshraghi, Francesca Pantaleoni, Rahim Vakili, Morteza Moghaddassian, Martha Ghahraman, Valentina Muto, Stefano Paolacci, Fatemeh Fardi Golyan, Mohammad Reza Abbaszadegan
      Purpose Noonan Syndrome (NS) is an autosomal dominant disorder with many variable and heterogeneous conditions. The genetic basis for 20–30% of cases is still unknown. This study evaluates Iranian Noonan patients both clinically and genetically for the first time. Materials/methods Mutational analysis of PTPN11 gene was performed in 15 Iranian patients, using PCR and Sanger sequencing at phase one. Then, as phase two, Next Generation Sequencing (NGS) in the form of targeted resequencing was utilized for analysis of exons from other related genes. Homology modelling for the novel founded mutations was performed as well. The genotype, phenotype correlation was done according to the molecular findings and clinical features. Results Previously reported mutation (p.N308D) in some patients and a novel mutation (p.D155N) in one of the patients were identified in phase one. After applying NGS methods, known and new variants were found in four patients in other genes, including: CBL (p. V904I), KRAS (p. L53W), SOS1 (p. I1302V), and SOS1 (p. R552G). Structural studies of two deduced novel mutations in related genes revealed deficiencies in the mutated proteins. Following genotype, phenotype correlation, a new pattern of the presence of intellectual disability in two patients was registered. Conclusions NS shows strong variable expressivity along the high genetic heterogeneity especially in distinct populations and ethnic groups. Also possibly unknown other causative genes may be exist. Obviously, more comprehensive and new technologies like NGS methods are the best choice for detection of molecular defects in patients for genotype, phenotype correlation and disease management.

      PubDate: 2017-09-30T16:22:38Z
      DOI: 10.1016/j.advms.2017.07.001
  • Pediatric reference data on activity of urinary
           N-acetyl-β-D-hexosaminidase and its isoenzymes
    • Authors: B. Zalewska-Szajda; K. Taranta-Janusz; S. Chojnowska; N. Waszkiewicz; K. Zwierz; A. Wasilewska
      Pages: 94 - 99
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): B. Zalewska-Szajda, K. Taranta-Janusz, S. Chojnowska, N. Waszkiewicz, K. Zwierz, A. Wasilewska
      Purpose The objective of the study was to establish age − dependent values of the urinary lysosomal exoglycosidases activities: N-acetyl-β-D-hexosaminidase (HEX) and its isoenzyme A (HEX A) as well as isoenzyme B (HEX B) in healthy children and adolescents. Material and methods The study was performed using a random sample of 203 healthy children and adolescents (girls=99, boys=104), aged six months to 17.9 years. The activities of HEX, HEX A and HEX B were determined by a colorimetric method. The activities of the urinary HEX and its isoenzymes were expressed in pKat/μg of creatinine (pKat/μg Cr). Results Median concentrations of urinary HEX, and its HEX A, HEX B isoenzymes in particular age groups were analyzed using ANOVA. Urinary HEX, HEX A and HEX B activities (pKat/μg Cr) were the highest in children below 3 years, in comparison to remaining age groups. There were statistically significant negative correlations between urinary HEX, HEX A as well as HEX B and age (r=−0.24, p<0.001 (HEX); r=−0.20, p<0.01 (HEX A); r=−0.26, p<0.001 (HEX B), respectively. We constructed the reference values for urinary activity of HEX, HEX A and HEX B (pKat/μg Cr) in centiles according to age, in three-year intervals. Conclusions Reported data present, for the first time, reference values for urinary activities of HEX and its isoenzymes HEX A and HEX B in children and adolescent.

      PubDate: 2017-09-06T00:04:35Z
      DOI: 10.1016/j.advms.2017.06.007
  • Pharmacological thrombolysis for acute ischemic stroke treatment: Gender
           differences in clinical risk factors
    • Authors: Michael J. Colello; Lauren E. Ivey; Jordan Gainey; Rakiya V. Faulkner; Ashleigh Johnson; Leanne Brechtel; Lee Madeline; Thomas I. Nathaniel
      Pages: 100 - 106
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Michael J. Colello, Lauren E. Ivey, Jordan Gainey, Rakiya V. Faulkner, Ashleigh Johnson, Leanne Brechtel, Lee Madeline, Thomas I. Nathaniel
      Background In a stroke population, women have a worse outcome than men when untreated. In contrast, there is no significant difference in treated patients. In this study, we determined whether clinical variables represent a promising approach to assist in the evaluation of gender differences in a stroke population. Methods We analyzed data from ischemic stroke patients’ ≥18 years-old from the stroke registry on rtPA administration and identified gender differences in clinical factors within inclusion and exclusion criteria in a stroke population that received rtPA. Multivariate analysis was used to adjust for patient demographic and clinical variables. Results Of the 241 eligible stroke patients’ thrombolytic therapy, 49.4% were females and 50.6% were males. Of the 422 patients that did not receive rtPA, more women (235) were excluded from rtPA than men (187) (P<0.05). In the male population, exclusion from rtPA was associated with history of a previous stroke (P<0.05, OR=2.028), hypertension (P<0.05, OR=0.519), and NIH stroke score (P<0.0001, OR=0.893). In female stroke patients, exclusion from rtPA was associated with previous history of stroke (P<0.05, OR=2.332), diabetes (P<0.05, OR=1.88) and NIH stroke score (P<0.05, OR=0.916). Conclusions Despite similarities in different areas of stroke care for both men and women, more women with diabetes, previous history of stroke and higher NIH scores are more likely to be excluded from thrombolytic therapy. Men with a previous history of stroke, hypertension and higher NIH scores are more likely to be excluded rtPA even after adjustment for confounding variables.

      PubDate: 2017-10-09T18:49:41Z
      DOI: 10.1016/j.advms.2017.08.003
  • Physeal fractures of the lower leg in children and adolescents:
           Therapeutic results, pitfalls and suggested management protocol-based on
           the experience of the authors and contemporary literature
    • Authors: Marcin Karlikowski; Jerzy Sułko
      Pages: 107 - 111
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Marcin Karlikowski, Jerzy Sułko
      Introduction Physeal fractures in children frequently give rise to concerns about the condition of the growth plate. Our observations have proven that the dysfunction of the growth plate is less frequent complication in those cases than misdiagnosed interposition of the periosteum. The aim of this paper is to familiarize the readers with the issue of treatment of physeal fractures of the distal tibia and fibula in the growing skeleton. Materials and methods We analyzed the group of 75 patients – children and adolescents – with surgically treated physeal fractures of the lower leg. The analysis included age, sex, circumstances of trauma infliction, type of sustained damage, employed therapeutic technique, timing of surgical procedure, duration of hospitalization, complications, duration of follow-up, radiological and functional results according to the AOFAS scale. Results The group consisted of 23 girls and 52 boys. The mean age was 13.6 years. The most frequent cause of trauma was same-level fall, usually during sports activities (35 cases). The most common type of damage was Salter-Harris type II fracture (35 cases). Among the employed surgical techniques, open reduction and stabilization with K-wires was the most often used (52 cases). A group of four patients attracted our attention, in whom after a closed reduction, signs of periosteum interposition were noted. These patients required a second procedure. In one patient, the growth plate arrest occurred; it was directly caused by local osteomyelitis. Conclusions With adequately conducted treatment of distal tibia and distal fibula physeal fractures, the results are good. Misdiagnosed periosteum interposition poses a more serious clinical problem as opposed to the commonly anxiety-provoking post-traumatic growth plate dysfunction.

      PubDate: 2017-10-29T01:59:58Z
      DOI: 10.1016/j.advms.2017.10.001
  • Effect of gestational age on migration ability of the human umbilical cord
           vein mesenchymal stem cells
    • Authors: Mobin Mohammadi; Mehdi Mohammadi; Mohammad Ali Rezaee; Tayyeb Ghadimi; Massume Abolhasani; Mohammad Reza Rahmani
      Pages: 119 - 126
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Mobin Mohammadi, Mehdi Mohammadi, Mohammad Ali Rezaee, Tayyeb Ghadimi, Massume Abolhasani, Mohammad Reza Rahmani
      Purpose Migration ability of mesenchymal stem cells (MSCs) towards chemotactic mediators is a determinant factor in cell therapy. MSCs derived from different sources show different properties. Here we compared the migration ability of the term and the pre-term human umbilical cord vein MSCs (hUCV-MSCs). Materials/Methods MSCs were isolated from term and pre-term umbilical cord vein, and cultured to passage 3–4. Migration rate of both groups was assessed in the presence of 10% FBS using chemotaxis assay. Surface expression of CXCR4 was measured by flow cytometery. The relative gene expression of CXCR4, IGF1-R, PDGFRα, MMP-2, MMP-9, MT1-MMP and TIMP-2 were evaluated using real time PCR. Results The isolation rate of the pre-term hUCV-MSCs was higher than the term hUCV-MSCs. Phenotype characteristics and differentiation ability of the term and pre-term hUCV-MSCs were not different. The migration rate of the pre-term hUCV-MSCs was more than the term hUCV-MSCs. Gene and surface expressions of the CXCR4 were both significantly higher in the pre-term hUCV-MSCs (P≤0.05). The mRNA levels of PDGFRα, MMP-2, MMP-9, MT1-MMP and TIMP-2 showed no significant difference between the two groups. Conclusion Our results showed that the gestational age can affect the migration ability of the hUCV-MSCs.

      PubDate: 2017-11-11T11:04:24Z
      DOI: 10.1016/j.advms.2017.08.002
  • Ultrastructural characteristics of the respective forms of hepatic
           stellate cells in chronic hepatitis B as an example of high fibroblastic
           cell plasticity. The first assessment in children
    • Authors: Joanna Maria Lotowska; Maria Elzbieta Sobaniec-Lotowska; Dariusz Marek Lebensztejn
      Pages: 127 - 133
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Joanna Maria Lotowska, Maria Elzbieta Sobaniec-Lotowska, Dariusz Marek Lebensztejn
      Purpose Activation of hepatic stellate cells (HSCs), mainly responsible for extracellular matrix synthesis, is assumed to be central event in the process of liver fibrogenesis. The major objective of the research was to analyze the ultrastructural profile of activated HSCs in children with chronic hepatitis B (chB), with respect to fibrosis intensity. Materials/methods Ultrastructural investigations of HSCs were conducted on liver bioptates from 70 children with clinicopathologically diagnosed chB before antiviral treatment. Biopsy material, fixed in paraformaldehyde and glutaraldehyde solution, was routinely processed for electron-microscopic analysis. Results In children with intensive liver fibrosis (S-2 and S-3), the ultrastructural picture showed almost total replacement of quiescent HSCs (Q-HSCs) by activated, i.e. transitional HSCs (T-HSCs). Among T-HSCs, two types of cells were distinguished: cells exhibiting initiation of HSC activation (Ti-HSCs), never before described in chB, that were frequently accompanied by activated Kupffer cells, and cells with features of perpetuation of activation (Tp-HSCs). Tp-HSCs were elongated and characterized by substantial loss of cytoplasmic lipid material; they contained an increased number of cytoskeletal components, extremely dilated channels of granular endoplasmic reticulum and activated Golgi apparatus, which indicated their marked involvement in intensive synthesis of extracellular matrix proteins. Many collagen fibers were found to adhere directly to Tp-HSCs. Conclusions The current study showed T-HSCs to be an important link between Q-HSCs and myofibroblastic HSCs (Mf-HSCs). Transformation of HSCs into new morphological variations (Ti-HSCs; Tp-HSCs and Mf-HSCs), observed along with growing fibrosis, indicates their high plasticity and a key role in fibrogenesis in pediatric chB.

      PubDate: 2017-11-11T11:04:24Z
      DOI: 10.1016/j.advms.2017.09.002
  • The protective effects of Bacillus licheniformis preparation on
           gastrointestinal disorders and inflammation induced by radiotherapy in
           pediatric with central nervous system tumor
    • Authors: Shu-Xu Du; Yong-Rui Jia; Si-Qi Ren; Xiao-Jun Gong; Hong Tang; Wu Wan-Shui; Sun Li-Ming
      Pages: 134 - 139
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Shu-Xu Du, Yong-Rui Jia, Si-Qi Ren, Xiao-Jun Gong, Hong Tang, Wu Wan-Shui, Sun Li-Ming
      Purpose we studied the effect of Bacillus licheniformis preparation (ZCS) on CNST (central nervous system tumor) patients undergoing the gastrointestinal symptoms and inflammation induced by radiotherapy. Materials and Methods 160 CNST patients with craniospinal irradiation (CSI) treatment were divided into experiment and control group. The experiment group patients took one capsule per time of ZCS and three times a day until the end of radiotherapy, starting one day before radiotherapy. While the patients in control group were administrated placebo without any probiotics. Serum from one day before radiotherapy and the first day after radiotherapy were collected to measure the ET, CRP, TNF-α, IL-1β and IL-6. Results More than 70% CNST pediatric patients suffered from different degrees of gastrointestinal symptoms after radiotherapy, including mouth ulcer, nausea, vomiting, abdominal pain and diarrhea. And there was an obviously increased of serum ET, TNF-α, IL-1β, IL-6 and CRP after RT. Importantly, a markedly decreased of ET, CRP and inflammatory cytokines were detected in the experiment group comparing to the control group after radiotherapy, as well as the relief of the gastrointestinal symptoms. However, improvement of probiotics (or ZCS) of the survival rate of CNST children and the recurrence of tumor are not observed in this study. Conclusions Prophylactically administrated ZCS during radiotherapy for CNST patients can relieve RT-related gastrointestinal symptoms and inflammatory reaction.

      PubDate: 2017-11-11T11:04:24Z
      DOI: 10.1016/j.advms.2017.09.005
  • The application of L-PRP in AIDS patients with crural chronic ulcers: A
           pilot study
    • Authors: Agata Cieslik-Bielecka; Rafał Skowroński; Magdalena Jędrusik-Pawłowska; Marcin Pierchała
      Pages: 140 - 146
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Agata Cieslik-Bielecka, Rafał Skowroński, Magdalena Jędrusik-Pawłowska, Marcin Pierchała
      Nonhealing wounds or skin ulcerations are the result of insufficient repair and destruction of a local healing potential. Opportunistic infections which cause a lot of ulcer complications influence the worsening general condition of patients with AIDS, ultimately leading to death. The chronicity of the condition and poor results of conventional therapy have prompted the search for new methods of treatment. We have examined venous or arteriovenous insufficiency-related extensive crural ulcers in AIDS patients. Crural ulcer healing processes were evaluated with clinical observations and histopathological, immunohistochemical and molecular examinations of tissue samples harvested from the wound edges before and on day 10 after L-PRP cover dressing. Clinical observations showed positive effects of L-PRP in all patients. However, complete wound closure was noted in 60% of cases. Statistical analysis of histological examination showed increased epidermal processes between samples, but the difference was nonsignificant. However, immunohistochemical investigations showed an increased healing process with strong statistical significance. The mean VEGF level before L-PRP usage was 114.3 vessels/mm2 and on day 10 118.9 (p=0.001523). The mean FLK level was 103.2 and 109.9 respectively (p=0.008241). The biggest differences were observed for CD34, with values of 68.2 on day 0 and 100.8 on day 10 (p=0.006982). Molecular analysis generally showed decreased gene expression and confirmed vascular formation and reepithelialization processes. In our opinion, L-PRP may be used to eradicate microorganisms from wounds, to induce neovascularization, and in unhealed cases prepare the base and edge of the ulcer for skin grafting and tissue expansion procedures.

      PubDate: 2017-11-11T11:04:24Z
      DOI: 10.1016/j.advms.2017.10.002
  • PPARγ Pro12Ala and C161T polymorphisms in patients with acne vulgaris:
           Contribution to lipid and lipoprotein profile
    • Authors: Shohreh Saeidi; Foroogh Chamaie-Nejad; Ali Ebrahimi; Fariba Najafi; Ziba Rahimi; Asad Vaisi-Raygani; Ebrahim Shakiba; Zohreh Rahimi
      Pages: 147 - 151
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Shohreh Saeidi, Foroogh Chamaie-Nejad, Ali Ebrahimi, Fariba Najafi, Ziba Rahimi, Asad Vaisi-Raygani, Ebrahim Shakiba, Zohreh Rahimi
      Purpose The aim of present study was to clarify the role of peroxisome proliferator-activated receptor γ (PPARγ) Pro12Ala and C161T variants in the pathogenesis of acne vulgaris (AV) and their influence on lipid and lipoprotein profile. Methods The present case-control study consisted of 393 individuals including 198 patients with AV (mild-, moderate-, and severe-AV) and 195 unrelated age-matched healthy individuals from Western Iran. The PPARγ Pro12Ala and C161T polymorphisms were identified using polymerase chain reaction-restriction length polymorphism method. Also, serum lipid and lipoprotein profile and fasting blood sugar (FBS) were detected in studied individuals. Results In women patients with AV significantly higher serum levels of FBS, total cholesterol, low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol compared to healthy women were detected. Neither PPARγ Pro12Ala nor C161T polymorphism was associated with the risk of AV but the Pro allele was a risk factor for AV among all men and women patients ≥20years. The variant genotype of PPARγ CG (Pro/Ala) was associated with significantly higher levels of total cholesterol and triglycerides compared to CC (Pro/Pro) genotype. We detected a significantly lower level of FBS in the presence of CT+TT genotype of PPARγ C161T compared to CC genotype. Also, carriers of PPARγ TT genotype had significantly lower serum level of total cholesterol and LDL-C compared to CC genotype. Conclusions Our results demonstrated the association of PPARγ Pro allele with susceptibility to AV in patients ≥20years and the influence of PPARγ Pro12Ala and C161T polymorphisms on the lipid and lipoprotein profile.

      PubDate: 2017-11-11T11:04:24Z
      DOI: 10.1016/j.advms.2017.09.003
  • The safety and efficacy of light emitting diodes-based ultraviolet A1
           phototherapy in bleomycin-induced scleroderma in mice
    • Authors: Diana Karpec; Romualdas Rudys; Laima Leonaviciene; Zygmunt Mackiewicz; Ruta Bradunaite; Gailute Kirdaite; Algirdas Venalis
      Pages: 152 - 159
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Diana Karpec, Romualdas Rudys, Laima Leonaviciene, Zygmunt Mackiewicz, Ruta Bradunaite, Gailute Kirdaite, Algirdas Venalis
      Purpose To define the efficacy and safety of narrowband ultraviolet A1 (UVA1) for the treatment of dermal fibrosis in bleomycin-induced mouse model of scleroderma. Materials and methods 42 DBA/2 strain mice were included in the study: healthy mice and mice with established scleroderma, treated with high or medium dose of UVA1. Non-treated groups served as control. The equipment emitting 365±5nm UVA1 radiation was used in the study. The average cumulative doses were 1200J/cm2 for high and 600J/cm2 for medium dose course. Histological analysis was performed for the evaluation of the dermal thickness and mast cells density. The expressions of p53 and Ki-67 proteins were assessed by immunohistochemical analyses. Results Skin thickness of mice with scleroderma, treated with high and medium dose of UVA1, were lower (272.9±113.2μm and 394±125.9μm, respectively) in comparison to the dermal thickness of non-treated animals (599±55.7μm). The dermal mast cells count in mice with scleroderma was reduced after high and medium dose treatment to 11±1.7 and 13±2.2, respectively, as compared to that in non-treated mice (23±3.0). No significant upregulation of p53 nor Ki-67 proteins was observed in the skin of healthy mice and mice with scleroderma after high- and medium-dose of UVA1. Conclusions The results of this study indicate that 365nm UVA1 with the cumulative doses of 1200J/cm2 and 600J/cm2 is safe and effective for the dermal fibrosis treatment.

      PubDate: 2017-11-11T11:04:24Z
      DOI: 10.1016/j.advms.2017.09.001
  • Prognostic value of fibrosis-related markers in dilated cardiomyopathy: A
           link between osteopontin and cardiovascular events
    • Authors: Paweł Rubiś; Sylwia Wiśniowska-Śmiałek; Ewa Dziewięcka; Lucyna Rudnicka-Sosin; Artur Kozanecki; Piotr Podolec
      Pages: 160 - 166
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Paweł Rubiś, Sylwia Wiśniowska-Śmiałek, Ewa Dziewięcka, Lucyna Rudnicka-Sosin, Artur Kozanecki, Piotr Podolec
      Introduction Serum markers of fibrosis provide an insight into extracellular matrix (ECM) fibrosis in heart failure (HF) and dilated cardiomyopathy (DCM). However, their role as predictors of cardiovascular (CV) events in DCM is poorly understood. Methods This is an observational, prospective cohort study. 70 DCM patients (48±12.1years, ejection fraction – EF 24.4±7.4) were recruited. Markers of collagen type I and III synthesis – procollagen type I and III carboxy- and amino-terminal peptides (PICP, PIIICP, PINP, PIIINP), fibrosis controlling factors – ostepontin (OPN), transforming growth factor (TGF1-β) and connective tissue growth factor (CTGF), and matrix metalloproteinases (MMP-2, MMP-9) and tissue inhibitor (TIMP-1), were measured in serum. All patients underwent endomyocardial biopsy. The end-point was combined with CV death and urgent HF hospitalization. Patients were divided into two groups: those who did (group 1, n=45) and did not reach (group 2, n=25) an end-point. Results Over a 12-month period of observation, 6 CV deaths and 19 HF hospitalizations occurred. Qualitative and quantitative measures of ECM fibrosis were similar in both groups. The levels of all of the markers of collagen synthesis, TGF1-β, MMP-9 and TIMP-1 were similar, however, OPN, CTGF and MMP-2 were significantly lower in group 1. Conclusions Invasively-determined fibrosis levels were not related with CV outcomes in DCM. Out of the 11 markers of fibrosis under study, only OPN was found to be related to CV outcomes. OPN is not only the pivotal protein controlling fibrosis, but may also serve as a biomarker associated with prognosis.

      PubDate: 2017-11-11T11:04:24Z
      DOI: 10.1016/j.advms.2017.10.004
  • Perioperative thrombocytopenia predicts poor outcome in patients
           undergoing transcatheter aortic valve implantation
    • Authors: Maciej Mitrosz; Remigiusz Kazimierczyk; Malgorzata Chlabicz; Bozena Sobkowicz; Ewa Waszkiewicz; Anna Lisowska; Slawomir Dobrzycki; Wlodzimierz J. Musial; Tomasz Hirnle; Karol A. Kaminski; Agnieszka M. Tycinska
      Pages: 179 - 184
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Maciej Mitrosz, Remigiusz Kazimierczyk, Malgorzata Chlabicz, Bozena Sobkowicz, Ewa Waszkiewicz, Anna Lisowska, Slawomir Dobrzycki, Wlodzimierz J. Musial, Tomasz Hirnle, Karol A. Kaminski, Agnieszka M. Tycinska
      Purpose To determine the time point at which thrombocytopenia after TAVI procedure is an indicator of the worst prognosis, with special consideration of perioperative platelet and coagulation activation as its potential causes. Methods Thirty two patients (mean age 78.5±7.9years, 62% females) qualified for TAVI procedure were prospectively evaluated. Platelet counts were assessed at baseline and for the next three postoperative (POD) days. Platelet activation was evaluated by P-selectin (PS, serum, ELISA) and platelet factor 4 (PF-4, CTAD plasma), and blood coagulation activation by prothrombin fragments 1+2 (F1+2, plasma, ELISA). Composite end point (CEP) including death and the need of cardiovascular rehospitalization was assessed after a mean of 14.1±6.7months. Results During the follow up period half of the patients reached CEP. Thrombocytopenia was more profound and frequent in patients with CEP as compared to those without (p<0.05). No differences regarding either the biomarkers of platelet (PS, PF-4) or coagulation (F1+F2) activation between the groups with and without CEP were found. Patients with moderate-to-severe thrombocytopenia at baseline had worse prognosis (log-rank test, p=0.0003). Based on the receiver operating characteristic curve analysis, the differences between platelet count on each postoperative day and the baseline count did not have any predictive value in CEP occurrence. Conclusions Patients with thrombocytopenia following TAVI procedure have poor prognosis, however, the changes on the particular days are not more important than initial platelet count. Further studies are needed to evaluate platelet and blood coagulation activation as potential causes of thrombocytopenia and impaired prognosis related to it.

      PubDate: 2017-11-20T04:09:31Z
      DOI: 10.1016/j.advms.2017.11.001
  • Human saliva as a diagnostic material
    • Authors: Sylwia Chojnowska; Tomasz Baran; Iwona Wilińska; Paulina Sienicka; Iwona Cabaj-Wiater; Małgorzata Knaś
      Pages: 185 - 191
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Sylwia Chojnowska, Tomasz Baran, Iwona Wilińska, Paulina Sienicka, Iwona Cabaj-Wiater, Małgorzata Knaś
      Today blood biochemical laboratory tests are essential elements to the diagnosis and monitoring of the treatment of diseases. However, many researchers have suggested saliva as an preferable diagnostic material. The collection of saliva is simple, painless, cheap and safe, both for patients and medical staff. An additional advantage of saliva is the fact that it may be retrieved several times a day, which makes repeat analysis much easier. Furthermore, saliva has very high durability. Although 94–99% of salivary content is water, saliva also contains numerous cellular elements and many organic and inorganic substances, including most biological markers present in the blood and urine that may be used in the early detection and monitoring of many dental and general diseases.

      PubDate: 2017-11-20T04:09:31Z
      DOI: 10.1016/j.advms.2017.11.002
  • Limbic brain structures and burnout—A systematic review
    • Authors: YeeKong Chow; Jolanta Masiak; Emilia Mikołajewska; Dariusz Mikołajewski; Grzegorz Marcin Wójcik; Brian Wallace; Andy Eugene; Marcin Olajossy
      Pages: 192 - 198
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): YeeKong Chow, Jolanta Masiak, Emilia Mikołajewska, Dariusz Mikołajewski, Grzegorz Marcin Wójcik, Brian Wallace, Andy Eugene, Marcin Olajossy
      More profound understanding of the relationship between the burnout and the limbic system function can provide better insight into brain structures associated with the burnout syndrome. The objective of this review is to explore all evidence of limbic brain structures associated with the burnout syndrome. In total, 13 studies were selected. Four of them applied the neuroimaging technology to investigate the sizes/volumes of the limbic brain structures of burnout patients. Six other studies were to investigate the hypothalamus-pituitary-adrenal (HPA) axis of burnout patients. Based on the results of the studies on the HPA-axis and neuroimaging of the limbic brain structures, one can see great impact of the chronic occupational stress on the limbic structures in terms of HPA dysregulation, a decrease of BDNF, impaired neurogenesis and limbic structures atrophy. It can be concluded that chronic stress inhibits the feedback control pathway in the HPA axis, causes the decrease of brain-derived neurotrophic factor (BDNF), then impaired neurogenesis and eventually neuron atrophy.

      PubDate: 2017-12-01T09:08:35Z
      DOI: 10.1016/j.advms.2017.11.004
  • Is the Clock Drawing Test useful in the screening assessment of aged
           patients with chronic heart failure'
    • Authors: Karolina Piotrowicz; Małgorzata Fedyk-Łukasik; Anna Skalska; Tomasz Grodzicki
      Pages: 199 - 204
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Karolina Piotrowicz, Małgorzata Fedyk-Łukasik, Anna Skalska, Tomasz Grodzicki
      Purpose Cognitive impairment is one of the most common geriatric deficits in old patients with heart failure (HF), but there has been a lack of study on the utility of the Clock Drawing Test (CDT) when used with this group of patients. The aim of the study was to assess the usefulness of the CDT in the geriatric assessment of aged outpatients with chronic HF. Patients and methods A cross-sectional analysis of the results of the comprehensive geriatric assessment (CGA), including the CDT, of 92 aged outpatients with heart failure was conducted. Results We found a high prevalence of five examined geriatric problems. The majority of the patients presented signs of cognitive deterioration of different patterns and severity on the Clock Drawing Test. All the CDT scoring systems correlated significantly with the Mini-Mental Test Examination results. Conclusions It seems reasonable to perform the routine CGA with the CDT examination in all aged heart failure patients.

      PubDate: 2017-12-01T09:08:35Z
      DOI: 10.1016/j.advms.2017.11.005
  • Lotus tetragonolobus and Maackia amurensis lectins influence
           phospho-IκBα, IL-8, Lewis b and H type 1 glycoforms levels in H. pylori
           infected CRL-1739 gastric cancer cells
    • Authors: Iwona Radziejewska; Małgorzata Borzym-Kluczyk; Katarzyna Leszczyńska; Joanna Wosek; Anna Bielawska
      Pages: 205 - 211
      Abstract: Publication date: March 2018
      Source:Advances in Medical Sciences, Volume 63, Issue 1
      Author(s): Iwona Radziejewska, Małgorzata Borzym-Kluczyk, Katarzyna Leszczyńska, Joanna Wosek, Anna Bielawska
      Purpose Attachment of Helicobacter pylori to the mucous epithelial cells and the mucous layer is said to be a crucial step for infection development. Sugar antigens of gastric mucins (MUC5AC, MUC1) can act as receptors for bacterial adhesins. The aim of the study was to investigate if Lotus tetragonolobus and Maackia amurensis lectins influence the level of MUC1, MUC5AC, Lewis b, H type 1, sialyl Lewis x, phospho-IκBα and interleukin 8 in Helicobacter pylori infected gastric cancer cells. Materials and methods The study was performed with one clinical H. pylori strain and CRL-1739 gastric cancer cells. To assess the levels of mentioned factors immunosorbent ELISA assays were used. Results Coculture of cells with bacteria had no clear effect on almost all examined structures. After coculture with H. pylori and lectins, a decrease of the level of both mucins, Lewis b and H type 1 antigens was observed. Lectins addition had no effect on sialyl Lewis x. Maackia amurensis caused slight increase of phospho-IκBα while interleukin 8 level was decreased. Conclusions Lotus tetragonolobus and Maackia amurensis lectins can mediate in binding of Helicobacter pylori to gastric epithelium.

      PubDate: 2017-12-11T16:10:26Z
      DOI: 10.1016/j.advms.2017.06.003
  • Hysteroscopy in the treatment of uterine cesarean section scar
           diverticulum: A systematic review
    • Authors: Anna Abacjew-Chmylko; Dariusz G. Wydra; Hanna Olszewska
      Pages: 230 - 239
      Abstract: Publication date: September 2017
      Source:Advances in Medical Sciences, Volume 62, Issue 2
      Author(s): Anna Abacjew-Chmylko, Dariusz G. Wydra, Hanna Olszewska
      The aim of this paper is to review and to analyze the results of previous studies dealing with hysteroscopic treatment of postcesarean scar defects. A systematic review of publications indexed in MEDLINE/PubMed database identified a total of 11 studies dealing with resectoscopic treatment of postcesarean scar defect. The review was conducted in line with the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines and the PRISMA statement. In only few studies, patients were qualified for hysteroscopic surgery based on the measurement of the defect depth and thickness of residual myometrium above the pouch. Two principal techniques were used for the hysteroscopic treatment: resection of one edge of the scar diverticulum, and resection of the inferior and superior edges of the defect. Additionally, most authors performed electrocauterization of the niche bottom. Resectoscopic treatment turned out to be highly effective in the case of women with AUB. No complications of the hysteroscopic procedure have been reported. Methodological value of the reviewed studies was relatively low due to non-unified selection/verification criteria and incomplete, non-systematic postoperative assessment. In conclusion, hysteroscopic treatment seems to be a promising option in the management of postcesarean scar defects, but still further research is needed on the problem in question.

      PubDate: 2017-05-13T07:03:55Z
      DOI: 10.1016/j.advms.2017.01.004
  • Methods to evaluate arterial structure and function in children –
           State-of-the art knowledge
    • Authors: Piotr Skrzypczyk; Małgorzata Pańczyk-Tomaszewska
      Pages: 280 - 294
      Abstract: Publication date: September 2017
      Source:Advances in Medical Sciences, Volume 62, Issue 2
      Author(s): Piotr Skrzypczyk, Małgorzata Pańczyk-Tomaszewska
      Background With increasing rates of hypertension, obesity, and diabetes in the pediatric population, wide available, and reproducible methods are necessary to evaluate arterial structure and function in children and adolescents. Methods MEDLINE/Pubmed was searched for articles published in years 2012–2017 on methodology of, current knowledge on, and limitations of the most commonly used methods to evaluate central, proximal and coronary arteries, as well as endothelial function in pediatric patients. Results Among 1528 records screened (including 1475 records from years 2012 to 2017) 139 papers were found suitable for the review. Following methods were discussed in this review article: ultrasound measurements of the intima-media thickness, coronary calcium scoring using computed tomography, arterial stiffness measurements (pulse wave velocity and pulse wave analysis, carotid artery distensibility, pulse pressure, and ambulatory arterial stiffness index), ankle-brachial index, and methods to evaluate vascular endothelial function (flow-mediated vasodilation, peripheral arterial tonometry, Doppler laser flowmetry, and cellular and soluble markers of endothelial dysfunction). Conclusions Ultrasonographic measurement of carotid intima-media thickness and measurement of pulse wave velocity (by oscillometry or applanation tonometry) are highly reproducible methods applicable for both research and clinical practice with proved applicability for children aged ≥6 years or with height ≥120cm. Evaluation of ambulatory arterial stiffness index by ambulatory blood pressure monitoring is another promising option in pediatric high-risk patients. Clearly, further studies are necessary to evaluate usefulness of these and other methods for the detection of subclinical arterial damage in children.

      PubDate: 2017-05-13T07:03:55Z
      DOI: 10.1016/j.advms.2017.03.001
  • Ischaemic preconditioning – Current knowledge and potential future
           applications after 30 years of experience
    • Authors: Karolina Stokfisz; Anna Ledakowicz-Polak; Maciej Zagorski; Marzenna Zielinska
      Pages: 307 - 316
      Abstract: Publication date: September 2017
      Source:Advances in Medical Sciences, Volume 62, Issue 2
      Author(s): Karolina Stokfisz, Anna Ledakowicz-Polak, Maciej Zagorski, Marzenna Zielinska
      Ischaemic preconditioning (IPC) phenomenon has been known for thirty years. During that time several studies showed that IPC provided by brief ischaemic and reperfusion episodes prior to longer ischaemia can bestow a protective effect to both preconditioned and also remote organs. IPC affecting remote organs is called remote ischaemic preconditioning. Initially, most IPC studies were focused on enhancing myocardial resistance to subsequent ischaemia and reperfusion injury. However, preconditioning was found to be a universal phenomenon and was observed in various organs and tissues including the heart, liver, brain, retina, kidney, skeletal muscles and intestine. Currently, there are a lot of simultaneous studies are underway aiming at finding out whether IPC can be helpful in protecting these organs. The mechanism of local and remote IPC is complex and not well known. Several triggers, intracellular pathways and effectors, humoral, neural and induced by genetic changes may be considered potential pathways in the protective activity of local and remote IPC. Local and remote IPC mechanism may potentially serve as heart protection during cardiac surgery and may limit the infarct size of the myocardium, can be a strategy for preventing the development of acute kidney injury development and liver damage during transplantation, may protect the brain against ischaemic injury. In addition, the method is safe, non-invasive, cheap and easily applicable. The main purpose of this review article is to present new advances which would help to understand the potential mechanism of IPC. It also discusses both its potential applications and utility in clinical settings.

      PubDate: 2017-05-18T07:47:13Z
      DOI: 10.1016/j.advms.2016.11.006
  • Impact of exaggerated blood pressure response in normotensive individuals
           on future hypertension and prognosis: Systematic review according to
           PRISMA guideline
    • Authors: Karsten Keller; Kathrin Stelzer; Mir Abolfazl Ostad; Felix Post
      Pages: 317 - 329
      Abstract: Publication date: September 2017
      Source:Advances in Medical Sciences, Volume 62, Issue 2
      Author(s): Karsten Keller, Kathrin Stelzer, Mir Abolfazl Ostad, Felix Post
      Purpose Arterial hypertension (aHT) is the leading risk factor for morbidity and mortality worldwide. Blood pressure (BP) deviation at rest is well defined and accompanies risk for cardiovascular events and cardiovascular mortality. A growing body of evidence emphasises that an exaggerated blood pressure response (EBPR) in cardiopulmonary exercise testing (CPET) could help to identify seemingly cardiovascular healthy and normotensive subjects, who have an increased risk of developing aHT and cardiovascular events in the future. Materials and methods The PubMed online database was searched for published studies reporting exercise-related BP and both the risk of aHT and cardiovascular events in the future. Results We identified 18 original studies about EBPR in CPET, which included a total of 35,151 normotensive individuals for prediction of new onset of aHT in the future and 11 original studies with 43,012 enrolled subjects with the endpoint of cardiovascular events in the future. Although an EBPR under CPET is not well defined, a large number of studies emphasise that EBPR in CPET is associated with both new-onset aHT and cardiovascular events in the future. Conclusions A growing number of studies support the hypothesis that EBPR in CPET may be a diagnostic tool to identify subjects with an elevated risk of developing aHT and cardiovascular events in the future.

      PubDate: 2017-05-18T07:47:13Z
      DOI: 10.1016/j.advms.2016.11.010
  • Bacterial infections and hepatic encephalopathy in liver
           cirrhosis–prophylaxis and treatment
    • Authors: Damian Piotrowski; Anna Boroń-Kaczmarska
      Pages: 345 - 356
      Abstract: Publication date: September 2017
      Source:Advances in Medical Sciences, Volume 62, Issue 2
      Author(s): Damian Piotrowski, Anna Boroń-Kaczmarska
      Infections are common among patients with liver cirrhosis. They occur more often in cirrhotic patient groups than in the general population and result in higher mortality. One reason for this phenomenon is bacterial translocation from the intestinal lumen that occurs as a consequence of intestinal bacterial overgrowth, increased permeability and decreased motility. The most common infections in cirrhotic patients are spontaneous bacterial peritonitis and urinary tract infections, followed by pneumonia, skin and soft tissue infections. Intestinal bacterial overgrowth is also responsible for hyperammonemia, which leads to hepatic encephalopathy. All of these complications make this group of patients at high risk for mortality. The role of antibiotics in liver cirrhosis is to treat and in some cases to prevent the development of infectious complications. Based on our current knowledge, antibiotic prophylaxis should be administered to patients with gastrointestinal hemorrhage, low ascitic fluid protein concentration combined with liver or renal failure, and spontaneous bacterial peritonitis as a secondary prophylaxis, as well as after hepatic encephalopathy episodes (also as a secondary prophylaxis). In some cases, the use of non-antibiotic prophylaxis can also be considered. Current knowledge of the treatment of infections allows the choice of a preferred antibiotic for empiric therapy depending on the infection location and whether the source of the disease is nosocomial or community-acquired.

      PubDate: 2017-05-18T07:47:13Z
      DOI: 10.1016/j.advms.2016.11.009
  • Thrombocytopenia associated with TAVI—The summary of possible causes
    • Authors: Maciej Mitrosz; Malgorzata Chlabicz; Katarzyna Hapaniuk; Karol A. Kaminski; Bozena Sobkowicz; Jaroslaw Piszcz; Slawomir Dobrzycki; Wlodzimierz J. Musial; Tomasz Hirnle; Agnieszka M. Tycinska
      Pages: 378 - 382
      Abstract: Publication date: September 2017
      Source:Advances in Medical Sciences, Volume 62, Issue 2
      Author(s): Maciej Mitrosz, Malgorzata Chlabicz, Katarzyna Hapaniuk, Karol A. Kaminski, Bozena Sobkowicz, Jaroslaw Piszcz, Slawomir Dobrzycki, Wlodzimierz J. Musial, Tomasz Hirnle, Agnieszka M. Tycinska
      Thrombocytopenia (TP) following transcatheter aortic valve implantation (TAVI) procedure is a common phenomenon but the underlying mechanisms are neither well known nor described. Postinterventional severe TP is related to worse early and late outcome. Moreover, the statement of enhanced platelet and coagulation activation might justify even stronger antiplatelet and anticoagulation therapy following TAVI procedure. Thus, the examination of the pathomechanisms responsible for TP post TAVI seems to be crucial. Several hypotheses have been raised. TP can be caused by insufficient production or impaired platelet renewal. On the other hand, increased platelet activation, consumption and destruction might also be responsible for TP. These findings, mostly related to the procedure alone, need further investigation. Here, we summarize the potential multifactorial causes of post TAVI thrombocytopenia.

      PubDate: 2017-05-28T11:16:38Z
      DOI: 10.1016/j.advms.2017.04.003
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