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Showing 1 - 200 of 3175 Journals sorted alphabetically
A Practical Logic of Cognitive Systems     Full-text available via subscription   (Followers: 8)
AASRI Procedia     Open Access   (Followers: 14)
Academic Pediatrics     Hybrid Journal   (Followers: 28, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 22, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 90, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 25, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 33, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 5)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 6, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 376, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 2)
Acta Biomaterialia     Hybrid Journal   (Followers: 27, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 2)
Acta de Investigación Psicológica     Open Access   (Followers: 3)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (Followers: 1, SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 235, SJR: 3.683, h-index: 202)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.615, h-index: 21)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 10, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription  
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 2, SJR: 0.311, h-index: 16)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 1)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 25, SJR: 1.365, h-index: 73)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.383, h-index: 19)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 1)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 5, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 3, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 6)
Acute Pain     Full-text available via subscription   (Followers: 14)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 7)
Additive Manufacturing     Hybrid Journal   (Followers: 9, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 22)
Advanced Cement Based Materials     Full-text available via subscription   (Followers: 3)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 128, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 16, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 8, SJR: 0.299, h-index: 15)
Advances in Agronomy     Full-text available via subscription   (Followers: 12, SJR: 2.071, h-index: 82)
Advances in Anesthesia     Full-text available via subscription   (Followers: 27, SJR: 0.169, h-index: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 2)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 10, SJR: 1.054, h-index: 35)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 10, SJR: 0.801, h-index: 26)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 22, SJR: 1.286, h-index: 49)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 14, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
Advances in Botanical Research     Full-text available via subscription   (Followers: 2, SJR: 0.619, h-index: 48)
Advances in Cancer Research     Full-text available via subscription   (Followers: 28, SJR: 2.215, h-index: 78)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 7, SJR: 0.9, h-index: 30)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 2.139, h-index: 42)
Advances in Cell Aging and Gerontology     Full-text available via subscription   (Followers: 3)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 27, SJR: 0.183, h-index: 23)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 10, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 19, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 14, SJR: 0.223, h-index: 22)
Advances in Dermatology     Full-text available via subscription   (Followers: 14)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 10)
Advances in Digestive Medicine     Open Access   (Followers: 8)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 21)
Advances in Ecological Research     Full-text available via subscription   (Followers: 42, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 27, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 6)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 42, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 1)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 7)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 54, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 15)
Advances in Genetics     Full-text available via subscription   (Followers: 14, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 7)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 21, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 0.497, h-index: 31)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 23)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 1, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 36, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 2, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 3)
Advances in Life Course Research     Hybrid Journal   (Followers: 8, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Marine Biology     Full-text available via subscription   (Followers: 14, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 21)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 8)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 3)
Advances in Oncobiology     Full-text available via subscription   (Followers: 1)
Advances in Organ Biology     Full-text available via subscription   (Followers: 1)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 6, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 5, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 24, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 10)
Advances in Pharmacology     Full-text available via subscription   (Followers: 15, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 7)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 17)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 18, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 59)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 6, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.1, h-index: 2)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 5)
Advances in Space Research     Full-text available via subscription   (Followers: 375, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 5)
Advances in Surgery     Full-text available via subscription   (Followers: 9, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 29, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 17)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 46, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 6, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 333, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 6, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 9, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 429, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 31, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 43, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access   (Followers: 1)
Agriculture and Natural Resources     Open Access   (Followers: 2)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 56, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 5, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 11, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 9)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access   (Followers: 1)
Algal Research     Partially Free   (Followers: 9, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 5, SJR: 0.776, h-index: 35)
Alpha Omegan     Full-text available via subscription   (SJR: 0.121, h-index: 9)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 9, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 48, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 4)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 4)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 6)
American Heart J.     Hybrid Journal   (Followers: 50, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 50, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 42, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 10, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 31, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 26, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 32, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 42, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 189, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 62, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 6)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 25, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 27, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 27, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 37, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 6)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 61, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 14)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 4, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 39, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 165, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 10, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 11)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 1)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 22, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1)

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Journal Cover Annales d'Endocrinologie
  [SJR: 0.394]   [H-I: 30]   [2 followers]  Follow
   Full-text available via subscription Subscription journal
   ISSN (Print) 0003-4266
   Published by Elsevier Homepage  [3175 journals]
  • Bariatric surgery in adolescents with severe obesity: Review and state of
           the art in France
    • Authors: Régis Coutant; Natacha Bouhours-Nouet; Aurélie Donzeau; Mathilde Fauchard; Anne Decrequy; Jean Malka; Elise Riquin; Marion Beaumesnil; Agnès Sallé; Claire Briet; Philippe Topart; Françoise Schmitt
      Pages: 462 - 468
      Abstract: Publication date: October 2017
      Source:Annales d'Endocrinologie, Volume 78, Issue 5
      Author(s): Régis Coutant, Natacha Bouhours-Nouet, Aurélie Donzeau, Mathilde Fauchard, Anne Decrequy, Jean Malka, Elise Riquin, Marion Beaumesnil, Agnès Sallé, Claire Briet, Philippe Topart, Françoise Schmitt
      Severe obesity (body mass index>120% of BMI IOTF-30 cut off) and morbid obesity (BMI>140% of BMI IOTF-30 cut off) affect 5 to 10% of obese adolescents in France. Organic complications can be found in about 50% of these patients, and depressive symptoms in one-third of them. Finally, over 70% will suffer from adult morbid obesity associated with a marked increase in morbidity and mortality. However, the reversion of obesity strongly decreases, and may even cancels, these risks. In controlled randomized studies, lifestyle interventions have limited effectiveness on BMI in children (and none in adolescents). Bariatric surgery has been shown to have short-term effectiveness in adolescents with severe and morbid obesity: the average BMI loss after gastric banding was 11.6kg/m2 (95% confidence interval from 9.8 to 13.4), 16.6kg/m2 (95% confidence interval from 13.4 to 19.8) after bypass, and 14.1kg/m2 (95% confidence interval 10.8 to 17.5) after sleeve gastrectomy. The resolution of comorbidities was the main aim, as well as the improvement of quality of life. This is not a simple surgical intervention, and minor side effects have been reported in approximately 10–15% of teenagers who underwent surgery (more common with the gastric band), and severe side effects in nearly 1–5% (mainly with bypass). In France, recommendations regarding indications, the care pathway, multidisciplinary meetings, reference management structures and postoperative care have been published by the French National Health Authority (HAS) in 2016 to provide a framework for bariatric surgery in underage patients.

      PubDate: 2018-01-04T13:03:30Z
      DOI: 10.1016/j.ando.2017.03.002
  • Bilateral vertebral artery dissection revealing Cushing's syndrome
    • Authors: Iuliana Ilie; Julien Vouillarmet; Myriam Decaussin-Petrucci; Sophie Jeannin-Mayer; Jean-Christophe Lifante; Charles Thivolet; Lucien Marchand
      Abstract: Publication date: Available online 17 March 2018
      Source:Annales d'Endocrinologie
      Author(s): Iuliana Ilie, Julien Vouillarmet, Myriam Decaussin-Petrucci, Sophie Jeannin-Mayer, Jean-Christophe Lifante, Charles Thivolet, Lucien Marchand

      PubDate: 2018-03-19T21:37:27Z
      DOI: 10.1016/j.ando.2018.02.001
  • Non-islet-cell tumour hypoglycaemia (NICTH): About a series of
           6 cases
    • Authors: Arnaud Jannin; Stéphanie Espiard; Kanza Benomar; Christine Do Cao; Bénédicte Mycinski; Henri Porte; Michèle D’Herbomez; Nicolas Penel; Marie-Christine Vantyghem
      Abstract: Publication date: Available online 16 March 2018
      Source:Annales d'Endocrinologie
      Author(s): Arnaud Jannin, Stéphanie Espiard, Kanza Benomar, Christine Do Cao, Bénédicte Mycinski, Henri Porte, Michèle D’Herbomez, Nicolas Penel, Marie-Christine Vantyghem
      The purpose of this study was to analyse the characteristics of 6 patients managed in a university hospital between 1996 and 2016 for non-islet cell tumor hypoglycemia (NICTH), a form of hypoglycaemia due to the paraneoplastic secretion of IGF-2 or its related substances. Results Three of these 6 patients (50%), aged over 69 years, including 2 with acromegaloid phenotype, presented with a pleural solitary fibrous tumor (SFT), with median diameter 20 cm (interquartile range, 12.5–20.5) with a low median SUV (3.3 g/mL (QR, 2–7.5)) on 18F-FDG PET. The other 3 patients presented respectively neuroendocrine carcinoma (NEC) of the palate (70-year-old woman), retroperitoneal myxofibrosarcoma (66-year-old man) and meningeal hemangiopericytoma (36-year-old woman). All 3 were inoperable and did not respond to any therapy other than glucose solution. Corticosteroid therapy was effective in the 3 SFTs and the NEC. One of the SFTs recurred 10 years later with asymptomatic hypoglycemia, which resolved after reintervention. Median (IQR) blood glucose levels of the 6 patients was 0.4g/L (QR, 0.31–0.41), with hypoinsulinemia at 0.7mIU/L (QR 0.7–2.0), undetectable GH, low IGF-1, normal IGF-2 level in 5/6 cases, a high IGF-2:IGF-1 ratio at 26.9 (QR, 20.8–37.8), hypokalemia and hypomagnesemia. Conclusion NICTH is a rare syndrome, which should be considered in the presence of hypoinsulinemic hypoglycemia with low GH and IGF-1, and a IGF-2:IGF-1 ratio>10. Corticosteroid therapy was effective in elderly subjects, particularly with solitary fibrous tumor, which was generally operable. Hemangiopericytoma and myxofibrosarcoma had poor prognosis in younger patients.

      PubDate: 2018-03-19T21:37:27Z
      DOI: 10.1016/j.ando.2018.01.005
  • Cost of diabetic foot in France, Spain, Italy, Germany and United Kingdom:
           A systematic review
    • Authors: Huidi Tchero; Pauline Kangambega; Lucien Lin; Martin Mukisi-Mukaza; Solenne Brunet-Houdard; Christine Briatte; Gerald Reparate Retali; Emmanuel Rusch
      Abstract: Publication date: Available online 12 March 2018
      Source:Annales d'Endocrinologie
      Author(s): Huidi Tchero, Pauline Kangambega, Lucien Lin, Martin Mukisi-Mukaza, Solenne Brunet-Houdard, Christine Briatte, Gerald Reparate Retali, Emmanuel Rusch
      Aim Cost estimates for diabetic foot are available for developed countries based on cost data for different years. This study aimed to provide a comparison of the cost of diabetic foot in E5 (France, Spain, Italy, Germany, and the United Kingdom) and its characteristics across different conditions. Methods PubMed, Central and Embase databases were searched in February 2017 for English language publications. Bibliographies of relevant papers were also searched manually. Reviews and research papers from E5 regions reporting on cost of diabetic foot were included. Reported cost was converted to equivalent 2016 $ for comparison purposes. All the costs presented are mean cost per patient per year in 2016 $. Results Nine studies were included in the analysis. The total cost of amputation ranged from $ 15,046 in 2001 to $ 38,621 in 2005. The direct cost of amputation ranged from $ 13,842 in 2001 to $ 83,728 during 2005–2009. Indirect cost of amputation was more uniform, ranging from between $ 1,043 to $ 1,442. The direct cost of gangrene ranged from $ 3,352 in 2003 to $ 8,818 in Germany. Although, for the same year, 2003, the cost for Spain was almost double that for Germany. The total cost of an uninfected ulcer was $ 6,174 in 2002, but increased to $ 14,441 in 2005; for an infected ulcer the cost increased from $ 2,637 to $ 2,957. The different countries showed variations in the components used to calculate the cost of diabetic foot. Conclusions The E5 incurs a heavy cost from diabetic foot and its complications. There is an unmet need for the identification of cost-cutting strategies, as diabetic foot costs more than major cardiac diseases.

      PubDate: 2018-03-19T21:37:27Z
      DOI: 10.1016/j.ando.2017.11.005
  • J. Vouillarmet et al. in response to V. Aboyans et al. concerning the
           article by M. Helfre et al.: Usefulness of a systematic screening of
           carotid atherosclerosis in asymptomatic people with type 2 diabetes for
           cardiovascular risk reclassification. Ann Endocrinol (Paris).
    • Authors: Julien Vouillarmet; Marjorie Helfre; Claire Grange
      Abstract: Publication date: Available online 9 March 2018
      Source:Annales d'Endocrinologie
      Author(s): Julien Vouillarmet, Marjorie Helfre, Claire Grange

      PubDate: 2018-03-19T21:37:27Z
      DOI: 10.1016/j.ando.2018.01.001
  • CS Froján et al. in response to the article by SK Lim et al.: Biotin
           interferes with free thyroid hormone and thyroglobulin, but not TSH
           measurements using Beckman-Access immunoassays. Lim SK, Pilon A, Guéchot
           J. Ann Endocrinol (Paris) 2017;78(3):186–7
    • Authors: Camilo Silva Froján; María Llavero Valero; Nerea Varo Cenarruzabeitia; Javier Salvador Rodríguez
      Abstract: Publication date: Available online 9 March 2018
      Source:Annales d'Endocrinologie
      Author(s): Camilo Silva Froján, María Llavero Valero, Nerea Varo Cenarruzabeitia, Javier Salvador Rodríguez

      PubDate: 2018-03-19T21:37:27Z
      DOI: 10.1016/j.ando.2017.09.001
  • Decreased sensitivity of thyrotropin-thyroid hormone feedback control in
           hypothyroid and athyreotic patients treated with levothyroxine. Is serum
           triiodothyronine involved'
    • Authors: Darko Solter; Miljenko Solter
      Abstract: Publication date: Available online 9 March 2018
      Source:Annales d'Endocrinologie
      Author(s): Darko Solter, Miljenko Solter
      Objectives The search for optimal therapy for hypothyroidism is challenging and complex and is still going on. We investigated TSH-thyroid hormone feedback control in hypothyroid and athyreotic patients properly treated with levothyroxine (LT4), based on normal TSH values. Material and methods We randomly selected 150 hypothyroid, 110 athyreotic and 210 euthyroid subjects, determined their serum T4, T3 and TSH values and calculated T4/TSH and T3/T4 ratios. Results The TSH distribution in hypothyroidism was significantly shifted to the higher and that in athyreosis to the lower values from the normal distribution in euthyroid controls. This TSH-thyroid hormone dissociation in hypothyroidism was characterized with higher T4 and higher matched TSH values. We found 5% hypothyroid and 10% athyreotic patients normalize TSH only with hyperthyroxinemia. Serum T3 was lower in both hypothyroid groups and unaffected by a higher LT4 dose and higher serum T4 in athyreosis. Conclusion Our results suggest that the decreased serum T3 is a major cause of impaired TSH-thyroid hormone feedback control in hypothyroidism treated with LT4.

      PubDate: 2018-03-19T21:37:27Z
      DOI: 10.1016/j.ando.2017.11.003
  • Prostate adenocarcinoma in a young patient with multiple endocrine
           neoplasia 2B
    • Authors: Salwan Maqdasy; Nicole Costes-Chalret; Marie Batisse-Lignier; Silvère Baron; Igor Tauveron
      Abstract: Publication date: Available online 9 March 2018
      Source:Annales d'Endocrinologie
      Author(s): Salwan Maqdasy, Nicole Costes-Chalret, Marie Batisse-Lignier, Silvère Baron, Igor Tauveron

      PubDate: 2018-03-19T21:37:27Z
      DOI: 10.1016/j.ando.2017.09.002
  • Predictive factors of endocrine and exocrine insufficiency after resection
           of a benign tumour of the pancreas
    • Authors: Hélène Neophytou; Marc Wangermez; Elise Gand; Michel Carretier; Jérôme Danion; Jean-Pierre Richer
      Abstract: Publication date: Available online 8 March 2018
      Source:Annales d'Endocrinologie
      Author(s): Hélène Neophytou, Marc Wangermez, Elise Gand, Michel Carretier, Jérôme Danion, Jean-Pierre Richer
      Background The aim of the present study is to evaluate the risk factors of endocrine and exocrine insufficiency occurring few years after pancreatic resections in a consecutive series of patients who underwent pancreatoduodenectomy (PD), left pancreatectomy (LP) or enucleation for benign neoplasms at a referral centre. Methods Pancreatic exocrine insufficiency (PEI) was defined by the onset of steatorrhea associated with weight loss, and endocrine insufficiency was determinate by fasting plasma glucose. Association between pancreatic insufficiency and clinical, pathological, and perioperative features was studied using univariate and multivariate Cox regression analysis. Results A prospective cohort of 92 patients underwent PD (48%), LP (44%) or enucleation (8%) for benign tumours, from 2005 to 2016 in the University Hospital in Poitiers (France). The median follow-up was 68.6±42.4months. During the following, 54 patients developed exocrine insufficiency whereas 32 patients presented endocrine insufficiency. In the Cox model, a BMI>28kg/m2, being a man and presenting a metabolic syndrome were significantly associated with a higher risk to develop postoperative diabetes. The risks factors for the occurrence of PEI were preoperative chronic pancreatitis, a BMI<18.5kg/m2, tumours located in the pancreatic head, biological markers of chronic obstruction and fibrotic pancreas. Undergoing LP or enucleation were protective factors of PEI. Histological categories such as neuroendocrine tumours and cystadenomas were also associated with a decreased incidence of PEI. Conclusion Men with metabolic syndrome and obesity should be closely followed-up for diabetes, and patients with obstructive tumours, pancreatic fibrosis or chronic pancreatitis require a vigilant follow up on their pancreatic exocrine function.

      PubDate: 2018-03-19T21:37:27Z
      DOI: 10.1016/j.ando.2017.10.003
  • Secreting ectopic adrenal adenoma: A rare condition to be aware of
    • Authors: Yang Zhao; Hui Guo; Ying Zhao; Bingyin Shi
      Abstract: Publication date: Available online 7 March 2018
      Source:Annales d'Endocrinologie
      Author(s): Yang Zhao, Hui Guo, Ying Zhao, Bingyin Shi
      Ectopic adrenal adenoma causing chronic Cushing's syndrome (CS) is a rare phenomenon. Diagnosis is usually made years after disease onset because of the insidious nature of the ectopic adrenal gland and because it overlaps with common symptoms, such as overweight and hypertension, in the general population (Kreitschmann-Andermahr et al., 2015). Here, we report the case of a 46-year-old male with a 15-year history of severe hypertension, facial plethora, and centripetal obesity. During treatment for herpes zoster, the patient presented with severe hypokalemia and flaccid paralysis, characteristic changes associated with CS. The serum cortisol level was elevated and baseline adrenocorticotrophic hormone (ACTH) was suppressed. After administration of the low-dose overnight dexamethasone suppression test, plasma cortisol was 38.9μg/dL. A contrast computed tomography (CT) scan revealed normal adrenal glands and significant tumor adjacent to the right renal hilum measuring ∼3.6×2.3cm. The tumor was removed through retroperitoneoscopy, and pathological examination confirmed adrenocortical adenoma and myelolipoma metaplasia. The serum potassium level gradually became normal after surgical removal of the mass. In the current report, we have reviewed the pertinent literature and highlighted the importance of considering ectopic adrenal adenoma in the differential diagnosis of chronic CS with nonspecific symptoms.

      PubDate: 2018-03-19T21:37:27Z
      DOI: 10.1016/j.ando.2017.03.003
  • Combined modalities of surgery, radiotherapy, radiosurgery and
           chemotherapy for invasive pituitary carcinoma
    • Authors: Constantin Tuleasca; Mahmoud Messerer; Marc Levivier; Roy Thomas Daniel
      Abstract: Publication date: Available online 7 March 2018
      Source:Annales d'Endocrinologie
      Author(s): Constantin Tuleasca, Mahmoud Messerer, Marc Levivier, Roy Thomas Daniel

      PubDate: 2018-03-19T21:37:27Z
      DOI: 10.1016/j.ando.2017.01.003
  • Acid folic and pregnancy: A mandatory supplementation
    • Authors: Morgane Valentin; Perrine Coste Mazeau; Michel Zerah; Pierre François Ceccaldi; Alexandra Benachi; Dominique Luton
      Abstract: Publication date: Available online 9 February 2018
      Source:Annales d'Endocrinologie
      Author(s): Morgane Valentin, Perrine Coste Mazeau, Michel Zerah, Pierre François Ceccaldi, Alexandra Benachi, Dominique Luton
      Neural tube defects (NTD) occur in 0.5 to 2 per 1000 pregnancies with various handicaps for the affected child. It is now well established that folic acid deficiency (absolute or relative) is a predisposing factor to this type of malformation. Several randomized controlled trials showed that high-dose folic acid (4mg) is an essential factor for prevention of neural tube defects recurrence and significantly prevents the first occurrence of neural tube defects with a lower dose (0.4mg). Other etiologies can favor the occurrence of NTD such as MTHFR polymorphism, some antiepileptic therapies, obesity and pregestational mellitus diabetes. Necessity of a preconception folic acid supplementation or at least folate nutritional status evaluation should be known for all of us including patients and public.

      PubDate: 2018-02-15T21:38:41Z
      DOI: 10.1016/j.ando.2017.10.001
  • SFE/SFEDP adrenal insufficiency French consensus: Introduction and
    • Authors: Yves Reznik; Pascal Barat; Jérôme Bertherat; Claire Bouvattier; Frédéric Castinetti; Olivier Chabre; Philippe Chanson; Christine Cortet; Brigitte Delemer; Bernard Goichot; Damien Gruson; Laurence Guignat; Emmanuelle Proust-Lemoine; Marie-Laure Raffin Sanson; Rachel Reynaud; Dinane Samara Boustani; Dominique Simon; Antoine Tabarin; Delphine Zenaty
      Abstract: Publication date: Available online 12 January 2018
      Source:Annales d'Endocrinologie
      Author(s): Yves Reznik, Pascal Barat, Jérôme Bertherat, Claire Bouvattier, Frédéric Castinetti, Olivier Chabre, Philippe Chanson, Christine Cortet, Brigitte Delemer, Bernard Goichot, Damien Gruson, Laurence Guignat, Emmanuelle Proust-Lemoine, Marie-Laure Raffin Sanson, Rachel Reynaud, Dinane Samara Boustani, Dominique Simon, Antoine Tabarin, Delphine Zenaty
      The French endocrinology society (SFE) and the French pediatric endocrinology society (DFSDP) have drawn up recommendations for the management of primary and secondary adrenal insufficiency in the adult and child, based on an analysis of the literature by 19 experts in 6 work-groups. A diagnosis of adrenal insufficiency should be suspected in the presence of a number of non-specific symptoms except hyperpigmentation which is observed in primary adrenal insufficiency. Diagnosis rely on plasma cortisol and ACTH measurement at 8am and/or the cortisol increase after synacthen administration. When there is a persistant doubt of secondary adrenal insufficiency, insulin hypoglycemia test should be carried out in adults, adolescents and children older than 2 years. For determining the cause of primary adrenal insufficiency, measurement of anti-21-hydroxylase antibodies is the initial testing. An adrenal CT scan should be performed if auto-antibody tests are negative, then assay for very long chain fatty acids is recommended in young males. In children, a genetic anomaly is generally found, most often congenital adrenal hyperplasia. In the case of isolated corticotropin (ACTH) insufficiency, it is recommended to first eliminate corticosteroid-induced adrenal insufficiency, then perform an hypothalamic-pituitary MRI. Acute adrenal insufficiency is a serious condition, a gastrointestinal infection being the most frequently reported initiating factor. After blood sampling for cortisol and ACTH assay, treatment should be commenced by parenteral hydrocortisone hemisuccinate together with the correction of hypoglycemia and hypovolemia. Prevention of acute adrenal crisis requires an education of the patient and/or parent in the case of pediatric patients and the development of educational programs. Treatment of adrenal insufficiency is based on the use of hydrocortisone given at the lowest possible dose, administered several times per day. Mineralocorticoid replacement is often necessary for primary adrenal insufficiency but not for corticotroph deficiency. Androgen replacement by DHEA may be offered in certain conditions. Monitoring is based on the detection of signs of under- and over-dosage and on the diagnosis of associated auto-immune disorders.

      PubDate: 2018-01-15T13:47:44Z
      DOI: 10.1016/j.ando.2017.12.001
  • Are multisource levothyroxine sodium tablets marketed in Egypt
    • Authors: Basant A. Abou-Taleb; Maha Bondok; Mohamed Ismail Nounou; Nawal Khalafallah; Saleh Khalil
      Abstract: Publication date: Available online 27 December 2017
      Source:Annales d'Endocrinologie
      Author(s): Basant A. Abou-Taleb, Maha Bondok, Mohamed Ismail Nounou, Nawal Khalafallah, Saleh Khalil
      A clinical study was initiated in response to patients’ complaints, supported by the treating physicians, of suspected differences in efficacy among multisource levothyroxine sodium tablets marketed in Egypt. The study design was a multiple dose (100μg levothyroxine sodium tablet once daily for 6 months) and involved 50 primary hypothyroidism female patients (5 equal groups). Tablets administered included five tablet batches (two brands, three origin locations) purchased from local pharmacies in Alexandria. Assessment parameters (measured on consecutive visits) included the thyroid stimulating hormone, total and free levothyroxine. Tablet dissolution rate was determined (BP/EP 2014 & USP 2014). In vitro vs in vivovs correlations were developed. Clinical and pharmaceutical data confirmed inter-brand and inter-source differences in efficacy. Correlations examined indicated potential usefulness of in vitro dissolution test in detecting poor performing levothyroxine sodium tablets during shelf life.

      PubDate: 2018-01-04T13:03:30Z
      DOI: 10.1016/j.ando.2017.10.002
  • Hommage à Yvan Bachelot
    • Authors: Serge Halimi
      First page: 487
      Abstract: Publication date: December 2017
      Source:Annales d'Endocrinologie, Volume 78, Issue 6
      Author(s): Serge Halimi

      PubDate: 2017-12-12T06:05:06Z
      DOI: 10.1016/j.ando.2017.11.001
  • Serum GH concentrations must now be expressed in mass units in France…as
           in the rest of the world
    • Authors: Philippe Chanson; Rachel Reynaud; Régis Coutant; Agnès Linglart; Marc Nicolino; Patrice Rodien; Françoise Borson-Chazot; Antoine Tabarin; Yves Le Bouc; Marie-Liesse Piketty; Anne-Sophie Gauchez; Didier Chevenne; Dominique Porquet; Jean-Claude Souberbielle
      Pages: 488 - 489
      Abstract: Publication date: December 2017
      Source:Annales d'Endocrinologie, Volume 78, Issue 6
      Author(s): Philippe Chanson, Rachel Reynaud, Régis Coutant, Agnès Linglart, Marc Nicolino, Patrice Rodien, Françoise Borson-Chazot, Antoine Tabarin, Yves Le Bouc, Marie-Liesse Piketty, Anne-Sophie Gauchez, Didier Chevenne, Dominique Porquet, Jean-Claude Souberbielle

      PubDate: 2017-12-12T06:05:06Z
      DOI: 10.1016/j.ando.2017.11.002
  • Group 6. Modalities and frequency of monitoring of patients with adrenal
           insufficiency. Patient education
    • Authors: Laurence Guignat; Emmanuelle Proust-Lemoine; Yves Reznik; Delphine Zenaty
      Pages: 544 - 558
      Abstract: Publication date: December 2017
      Source:Annales d'Endocrinologie, Volume 78, Issue 6
      Author(s): Laurence Guignat, Emmanuelle Proust-Lemoine, Yves Reznik, Delphine Zenaty
      Patients with adrenal insufficiency require regular, specialised monitoring in order to optimise their replacement therapy, to detect signs of under- and over-dosage, and to examine for possible associated disorders (auto-immune disorders in the case of auto-immune primary adrenal insufficiency either isolated or as part of auto-immune polyendocrinopathy syndrome type 1; illnesses with underlying monogenic causes). The transition period between adolescence and adulthood represents an added risk of a breakdown in monitoring which requires particular attention from medical teams and coordination between adult and pediatric medical teams. It is essential to encourage patient autonomy in the management of their illness, notably their participation in treatment education programs, in particular programs that target avoidance of, or early treatment of acute adrenal insufficiency. The principal educational objectives for patients in such programs are: to be in possession of, and carry the necessary tools for their treatment in an emergency; to be able to identify situations of increased risk and the early signs of adrenal crisis; to know how to adjust their oral glucocorticoid treatment; to be capable of administering hydrocortisone by subcutaneous injection; to be able to predict and therefore adjust treatment to different situations (heat, physical exercise, travel) and to be able to correctly use the appropriate resources of the healthcare services. Other programs could also be developed to respond to needs and expectations of patients, notably concerning the adjustment of hydrocortisone dosage to avoid overdose in the context of chronic fatigue syndrome.

      PubDate: 2017-12-12T06:05:06Z
      DOI: 10.1016/j.ando.2017.10.009
  • Mélatonine et diabète : contribution de la
    • Authors: A. Bonnefond
      Pages: 202 - 203
      Abstract: Publication date: September 2017
      Source:Annales d'Endocrinologie, Volume 78, Issue 4
      Author(s): A. Bonnefond
      Nous avons démontré que des mutations rares et délétères du gène MTNR1B codant le récepteur 2 de la mélatonine (qui est un récepteur couplé aux protéines G [RCPG]) contribuent à une augmentation du risque de diabète de type 2 (DT2) ; ce qui corroborait avec des études épidémiologiques et in vitro ayant rapporté qu’une baisse de la signalisation de la mélatonine est associée à une augmentation du risque de DT2. Cette conclusion a été dernièrement mise à mal par une étude suédoise. Nous avons ici continué notre travail d’investigation fonctionnelle des mutants de MTNR1B car les RCPG peuvent réguler de multiples voies de signalisation. Nous avons analysé l’effet de chaque mutant sur cinq voies de signalisation (l’activation des protéines Gαi1, Gαz et ERK, l’inhibition de l’AMPc et le recrutement de la β-arrestin-2) en basal ou en réponse à la mélatonine, comparé à l’effet de MTNR1B sauvage. L’association avec le DT2 a été analysée chez 2186 cas diabétiques et 4804 contrôles. Nous avons trouvé que les mutants entraînant un défaut d’activation des protéines Gαi1 ou Gαz étaient le plus fortement associés à une augmentation du risque de DT2 en réponse à la mélatonine. Par ailleurs, nous avons trouvé que les mutants sans effet délétère n’étaient pas associés au DT2. Cette étude souligne la grande complexité des RCPG et démontre que seulement certaines voies peuvent contribuer à la maladie. Nous avons par ailleurs confirmé l’association entre la perte de fonction de MTNR1B et une augmentation du risque de DT2.

      PubDate: 2017-09-24T08:25:58Z
      DOI: 10.1016/j.ando.2017.07.745
  • Actualisation sur l’hypoparathyroïdie : un peu de théorie,
           beaucoup de pratique
    • Authors: S. Espiard; M.-C. Vantyghem; R. Desailloud
      Abstract: Publication date: October 2017
      Source:Annales d'Endocrinologie, Volume 78, Supplement 1
      Author(s): S. Espiard, M.-C. Vantyghem, R. Desailloud
      La parathormone (PTH), sécrétée par les parathyroïdes, est le principal régulateur de l’homéostasie du calcium. L’hypoparathyroïdie (HypoPT), secondaire à une insuffisance de production de PTH, est une maladie rare. Elle entraîne des symptômes multiples, atteint plusieurs organes et conduit à une altération de la qualité de vie. On différencie les causes acquises, la principale étant l’HypoPT post-thyroïdectomie, et les causes congénitales, notamment génétiques. L’HypoPT, dont le traitement classique consiste en une supplémentation calcique et en vitamine D active, peut maintenant être traitée par injection de PTH recombinante dans certaines indications comme le mauvais contrôle sous traitement conventionnel. Les données actuelles sur les aspects physiopathologiques, épidémiologiques, cliniques et thérapeutiques sont revues dans ce manuscrit. Parathormone (PTH), produced by parathyroid glands, is the main regulator of calcium homeostasis. Hypoparathyroidism (hypoPT), due to decrease of PTH production, is a rare disease. Symptoms are multiple, altering function of several organs and leading to a decrease of quality of life. Acquired etiologies, including thyroïdectomy, the main cause of hypoPT, can be distinguished from congenital etiologies, including genetic defects. HypoPT, which is classically treated by supplementation by calcium and active vitamin D, can now be treated by recombinant injection in certain indications as a poor control under classical therapy. Here are summarized current knowledge on etiologies, epidemiology, clinical manifestations and management of hypoPT.

      PubDate: 2017-12-01T11:13:21Z
      DOI: 10.1016/s0003-4266(17)30920-4
  • La chirurgie d’épargne surrénalienne : du cortex à la
    • Authors: A. Ferriere; V. Kerlan; A. Tabarin
      Abstract: Publication date: October 2017
      Source:Annales d'Endocrinologie, Volume 78, Supplement 1
      Author(s): A. Ferriere, V. Kerlan, A. Tabarin
      Le congrès de l’Endocrine Society de 2017 a comporté plusieurs communications et débats sur la chirurgie surrénalienne conservatrice dans les phéochromocytomes héréditaires bilatéraux (PHB), l’hyperplasie macronodulaire bilatérale des surrénales (HMBS) et l’hyperaldostéronisme primaire (HAP). Le principe général est de préserver une partie du cortex surrénalien pour éviter la survenue d’une insuffisance surrénalienne définitive. Dans les PHB, la chirurgie d’épargne corticale permet à plus de 50 % des patients de garder une fonction surrénalienne normale à 10 ans pour un taux de récidive faible (~ 10 %). La médullo-surrénale ne pouvant être retirée en totalité, la récidive semble cependant inévitable et un suivi à long terme est indispensable. Ses indications doivent également tenir compte du risque individuel de malignité. Dans l’HMBS responsable d’un syndrome de Cushing, la surrénalectomie unilatérale induit une normalisation du cortisol libre urinaire (CLU) dans 92 à 100 % des cas voire une insuffisance corticotrope dans 40 à 100 % des cas. Celle-ci est le plus souvent transitoire. Des récidives tardives du syndrome de Cushing peuvent survenir dans 13 à 60 % des cas. Une surveillance prolongée des patients est donc indispensable. Dans l’HAP avec production latéralisée d’aldostérone, la chirurgie surrénalienne partielle mini-invasive, qui consiste à ne retirer que l’adénome surrénalien visualisé en laissant en place un maximum de glande saine, permet une amélioration de la tension artérielle chez environ 94 % de patients. Cependant, elle expose au risque d’échec ou de récidive. Sa place reste donc marginale dans le traitement des HAP latéralisés. The 2017 Endocrine Society annual meeting included several communications and debates on the conservative adrenal surgery in bilateral hereditary pheochromocytomas (BHP), bilateral adrenal macronodular hyperplasia (BAMH) and primary hyperaldosteronism (PHA). The general principle is to preserve a part of the adrenal cortex to prevent the occurrence of a definitive adrenal insufficiency. In BHP, cortical sparing surgery allows more than 50% of patients to maintain normal corticotropic function at 10 years with a low recurrence rate (~ 10%). Since the adrenal medulla cannot be removed entirely, recurrence seems inevitable and long-term follow-up is essential. Individual risk of malignancy must be taken into account. In BAMH responsible for Cushing syndrome, unilateral adrenalectomy induces a normalization of urinary free cortisol in 92 to 100% of cases and even corticotropic insufficiency in 40 to 100% of cases. This is most often transient. Late recurrences of Cushing’s syndrome may occur in 13 to 60% of cases. Prolonged patient monitoring is therefore essential. In PAH with lateralized aldosterone production, minimally invasive partial adrenal surgery, which consists of removing only the adrenal adenoma visualized at TDM, allows an improvement blood pressure in about 94% of patients. However, failure or recurrence may occur. Its place therefore remains marginal in the treatment of the lateralized PAHs.

      PubDate: 2017-12-01T11:13:21Z
      DOI: 10.1016/s0003-4266(17)30921-6
  • Contrôle de l’axe gonadotrope : nouveaux aspects physiologiques
           et thérapeutiques
    • Authors: L. Maione; S. Christin-Maître; P. Chanson; J. Young
      Abstract: Publication date: October 2017
      Source:Annales d'Endocrinologie, Volume 78, Supplement 1
      Author(s): L. Maione, S. Christin-Maître, P. Chanson, J. Young
      The endocrine and exocrine functions of the gonads are controlled by the gonadotrope axis, whose master regulator is the hypothalamic decapeptide GnRH. The Kisspeptin/Neurokinin B (Kp/NkB) neuronendocrine system is the main physiologic regulator of GnRH neurons. The Kp/NkB system is currently considered the key mediator for the hypothalamic negative feedback exerted by sex steroids and prolactin, as well as by various metabolic signals. Intrinsic alterations or regulatory abnormalities of Kp/NkB system lead to various gonadotrope axis puberty and fertility dysfunctions. Molecular inactivations of Kp/NkB system actors are associated with some forms of congenital hypogonadotropic hypogonadism without anosmia. The Kp/NkB System is also involved in a few forms of precocious puberty. Finally, the Kp/NKB system is also implicated in gonadotrope axis alterations leading to functional hypothalamic amenorrhea or hyperprolactinemia. NkB is particularly and directly involved in vasomotor menopausal hot flushes mechanism. Various Kp/NkB agonist/antagonist compounds have been developed during the last ten years, and are currently being evaluated in humans. These molecules have potential applications not only in rare genetic diseases with Kp/NkB alterations, but also in various gonadotrope axis-related diseases or in vitro fertilization. The administration of NkB antagonists in menopausal women represents a real therapeutic advance because of their impressive effect in controlling vasomotor menopausal hot flushes.

      PubDate: 2017-12-01T11:13:21Z
      DOI: 10.1016/s0003-4266(17)30923-x
  • L’hypophyse et ses traitements : comment peuvent-ils influer sur le
           comportement '
    • Authors: C. Mouly; F. Borson-Chazot; P. Caron
      Abstract: Publication date: October 2017
      Source:Annales d'Endocrinologie, Volume 78, Supplement 1
      Author(s): C. Mouly, F. Borson-Chazot, P. Caron
      Les hormones hypophysaires ou leurs traitements peuvent influencer le comportement. Les agonistes dopaminergiques (AD) employés dans le traitement des prolactinomes peuvent être à l’origine d’effets secondaires, et notamment de troubles compulsifs. Dans le cadre du traitement des prolactinomes, des troubles compulsifs ont été décrits à type de jeu pathologique, d’achats compulsifs, mais surtout d’hypersexualité. Ces troubles peuvent apparaître pour de faibles posologies d’AD, et semblent indépendants du type de molécule utilisée, ou des antécédents psychiatriques personnels. La principale hypothèse physiopathologique est une altération de la régulation des voies dopaminergiques impliquées dans les circuits de la récompense. Étant donné leurs conséquences sociales parfois importantes, ces troubles compulsifs doivent être dépistés chez les patients traités par AD. Notre comportement social peut être aussi influencé par l’ocytocine. Cette hormone sécrétée à l’état physiologique par la posthypophyse, mais également par certaines aires du cerveau et du tronc cérébral, a des effets sur le comportement social dans les relations d’attachement au sein du couple et dans la relation parent-enfant, mais également dans les comportements d’empathie. L’ocytocine influence également le comportement alimentaire, par une action anorexigène. Des études sur de petits effectifs ont évalué l’intérêt d’un traitement par ocytocine dans plusieurs pathologies endocriniennes et nutritionnelles telles que le craniopharyngiome opéré, le panhypopituitarisme et l’obésité. Malgré des résultats prometteurs, il existe encore plusieurs obstacles à l’utilisation de l’ocytocine en pratique clinique. Behaviour may be influenced by pituitary hormones or treatments. Dopamine agonist (DA) indicated in prolactinomas treatment can cause side effects, and especially impulse control disorders. In the context of prolactinomas treatment, impulse control disorders (ICD) have been reported like gambling, compulsive shopping, but mostly hypersexuality. These ICD can occur with low AD doses, and seem to be independent of type of molecule and psychiatric medical history. The main pathophysiologic hypothesis is a dysregulation of dopaminergic pathway involved in reward system. Given the possible devastating social impact of these ICD, they have to be screened in patients treated with DA. Our social behaviour can also be impacted by oxytocin. This hormone secreted on physiologic state at posterior pituitary, but also by others areas of brain and brainstem, has an impact on attachment in pair partners and in parent-child relationship, but also in empathy behaviour. Oxytocin affects as well eating behaviour with an anorexigenic impact. Studies on small populations assessed the relevance of an oxytocin treatment in several endocrine and nutritional pathologies like post-surgery craniopharyngioma, panhypopituitarism and obesity. Despite promising results, several pitfalls prevent yet the oxytocin use in clinical practice.

      PubDate: 2017-12-01T11:13:21Z
      DOI: 10.1016/s0003-4266(17)30924-1
  • Study of the metabolomics characteristics of patients with metabolic
           syndrome based on liquid chromatography quadrupole time-of-flight mass
    • Authors: Ning Wu; Wenbo Wang; Min Yi; Siying Cheng; Dongsheng Wang
      Abstract: Publication date: Available online 13 December 2017
      Source:Annales d'Endocrinologie
      Author(s): Ning Wu, Wenbo Wang, Min Yi, Siying Cheng, Dongsheng Wang
      Background Metabolic syndrome (MS) is a disease with complex pathophysiology and pathogenesis involving multiple systems of the human body. This study aimed to identify serum metabolites that are relevant to MS. Material and methods This study involved 40 patients with MS and 28 healthy adults, and the following data were statistically analyzed: basic clinical data, blood lipids, fasting blood glucose, blood pressure, waist circumference, and visceral fat coefficient. Serum samples from both groups were collected and analyzed by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF/MS); multivariate and univariate statistical methods were used to identify potential MS biomarkers and MS-related metabolic pathways. In addition, leucine and valine levels in serum from MS patients and normal subjects were measured using enzyme-linked immunosorbent assays (ELISAs). Results In this study, 23 potential biomarkers were identified in the plasma of MS patients. These biomarkers were mainly related to metabolism; the tricarboxylic acid cycle; galactose metabolism; arachidonic acid metabolism; valine, leucine, and isoleucine degradation; and valine, leucine, and isoleucine biosynthesis. ELISAs were utilized to verify serum leucine and valine levels, and the results supported the experimental metabolomics results. Conclusions In total, 23 MS-related metabolites were identified in the serum; these differential metabolites were mainly associated with lipid metabolism, amino acid metabolism, glucose metabolism, purine metabolism, and other related metabolic pathways. This study shows that LC/MS-based metabolomics methods can be used to investigate the pathological changes in MS patients and identify biomarkers for the early diagnosis of MS.

      PubDate: 2017-12-17T17:18:56Z
      DOI: 10.1016/j.ando.2017.05.005
  • A severe but reversible reduction in insulin sensitivity is observed in
           patients with insulinoma
    • Authors: Raluca Maria Furnica; Laure Istasse; Dominique Maiter
      Abstract: Publication date: Available online 11 December 2017
      Source:Annales d'Endocrinologie
      Author(s): Raluca Maria Furnica, Laure Istasse, Dominique Maiter
      Background Hypoglycemic manifestations are highly variable in patients with an insulinoma and largely independent of tumour size and severity of insulin hypersecretion. Objectives We investigated the clinical, biological and tumoral characteristics of insulinomas in a large monocentric series of patients and we evaluated their insulin sensitivity before and after successful pancreatic surgery. Patients and methods This was a retrospective analysis of 40 patients treated for an insulinoma between 1982 and 2012 in our academic hospital. Insulin sensitivity and beta cell function were evaluated by a HOMA test outside hypoglycaemic episodes in a large subset of these patients. Results The mean age at onset of symptoms was 48.8±20.1 years and the mean age at diagnosis was 50.7±19.9 years. Neuroglycopenic symptoms were observed in 90% of patients. The most effective preoperative imaging technique to localize the tumour was endoscopic ultrasound. Insulin sensitivity was greatly reduced in patients with insulinoma (38.9%±22.3%), while beta cells function was increased (359.0±171.5%), but to a variable extent (range: 110.6–678.6%). After complete resection of the tumour and remission of hypoglycemic episodes, insulin sensitivity increased in all evaluated subjects (72.8±36.7%) and normalized in the majority. Conclusion Although neuroglycopenic symptoms are present in most patients, diagnosis of insulinoma is often delayed. Endoscopic ultrasound remains the most sensitive preoperative technique to localize the tumour. We also show that in response to chronic hyperinsulinemia, patients with insulinoma develop protective mechanisms responsible for a marked insulin resistance, which is reversible after complete resection of the tumour.

      PubDate: 2017-12-12T06:05:06Z
      DOI: 10.1016/j.ando.2017.08.001
  • Unilateral aggressive pheochromocytoma revealed by a massive
           intraperitoneal hemorrhage five years after an initial presentation
           suggesting an adrenal hematoma
    • Authors: Olivier Gilly; Françoise Brucker-Davis; Jean-Louis Bernard; Anne Barlier; Hervé Quintard; Danièle Benisvy; Patrick Chevallier; Nicolas Chevalier
      Abstract: Publication date: Available online 11 December 2017
      Source:Annales d'Endocrinologie
      Author(s): Olivier Gilly, Françoise Brucker-Davis, Jean-Louis Bernard, Anne Barlier, Hervé Quintard, Danièle Benisvy, Patrick Chevallier, Nicolas Chevalier

      PubDate: 2017-12-12T06:05:06Z
      DOI: 10.1016/j.ando.2017.08.003
  • European recommendations for the management of adrenal incidentalomas: A
           debate on patients follow-up
    • Authors: Stéphanie Espiard; Kanza Benomar; Camille Loyer; Claire Vahé; Marie-Christine Vantyghem
      Abstract: Publication date: Available online 11 December 2017
      Source:Annales d'Endocrinologie
      Author(s): Stéphanie Espiard, Kanza Benomar, Camille Loyer, Claire Vahé, Marie-Christine Vantyghem

      PubDate: 2017-12-12T06:05:06Z
      DOI: 10.1016/j.ando.2017.08.002
  • Acknowledging our reviewers
    • Abstract: Publication date: December 2017
      Source:Annales d'Endocrinologie, Volume 78, Issue 6

      PubDate: 2017-12-12T06:05:06Z
  • Group 1. Epidemiology of primary and secondary adrenal insufficiency:
           Prevalence and incidence, acute adrenal insufficiency, long-term morbidity
           and mortality
    • Authors: Olivier Chabre; Bernard Goichot; Delphine Zenaty; Jérôme Bertherat
      Abstract: Publication date: Available online 27 November 2017
      Source:Annales d'Endocrinologie
      Author(s): Olivier Chabre, Bernard Goichot, Delphine Zenaty, Jérôme Bertherat
      The prevalence of primary adrenal insufficiency is estimated at between 82–144/million, with auto-immunity being the most common cause in adults and genetic causes, especially enzyme defects, being the most common cause in children. The prevalence of secondary adrenal deficiency is estimated to be between 150–280/million. The most frequent occurrence is believed to be corticosteroid-induced insufficiency, despite the incidence of clinically relevant deficiency after cessation of glucocorticoid treatment being widely debated. Data on mortality in adrenal insufficiency are contradictory, with studies from Sweden suggesting a two-fold increase in comparison to the general population, but this is not consistently reported in all studies. However, increased mortality has been consistently reported in young patients, associated with infection and/or acute adrenal insufficiency. Acute adrenal deficiency (adrenal crisis) occurs in primary as well as secondary adrenal insufficiency. Its incidence, mostly determined in retrospective studies, is estimated in Europe at 6–8/100 patients/year. A prospective study reported 0.5 deaths/100 patient-years from adrenal crisis. Long-term morbidity of adrenal insufficiency is not well-established, the increased cardiovascular risk or bone demineralization which are not consistently reported may also be due to a supraphysiological glucocorticoid replacement therapy. However, alteration in quality of life, both in physical and mental health components, has been demonstrated by several studies in both primary and secondary adrenal insufficiency.

      PubDate: 2017-12-01T11:13:21Z
      DOI: 10.1016/j.ando.2017.10.010
  • Group 3: Strategies for identifying the cause of adrenal insufficiency:
           diagnostic algorithms
    • Authors: Emmanuelle Proust-Lemoine; Rachel Reynaud; Brigitte Delemer; Antoine Tabarin; Dinane Samara-Boustani
      Abstract: Publication date: Available online 24 November 2017
      Source:Annales d'Endocrinologie
      Author(s): Emmanuelle Proust-Lemoine, Rachel Reynaud, Brigitte Delemer, Antoine Tabarin, Dinane Samara-Boustani

      PubDate: 2017-12-01T11:13:21Z
      DOI: 10.1016/j.ando.2017.10.006
  • Group 5: Acute adrenal insufficiency in adults and pediatric patients
    • Authors: Christine Cortet; Pascal Barat; Delphine Zenaty; Laurence Guignat; Philippe Chanson
      Abstract: Publication date: Available online 23 November 2017
      Source:Annales d'Endocrinologie
      Author(s): Christine Cortet, Pascal Barat, Delphine Zenaty, Laurence Guignat, Philippe Chanson

      PubDate: 2017-12-01T11:13:21Z
      DOI: 10.1016/j.ando.2017.10.008
  • Group 2: Adrenal insufficiency: screening methods and confirmation of
    • Authors: Philippe Chanson; Laurence Guignat; Bernard Goichot; Olivier Chabre; Dinane Samara Boustani; Rachel Reynaud; Dominique Simon; Antoine Tabarin; Damien Gruson; Yves Reznik; Marie-Laure Raffin Sanson
      Abstract: Publication date: Available online 23 November 2017
      Source:Annales d'Endocrinologie
      Author(s): Philippe Chanson, Laurence Guignat, Bernard Goichot, Olivier Chabre, Dinane Samara Boustani, Rachel Reynaud, Dominique Simon, Antoine Tabarin, Damien Gruson, Yves Reznik, Marie-Laure Raffin Sanson
      A diagnosis of adrenal insufficiency should be suspected in the presence of a number of non-specific symptoms (fatigue, anorexia, weight loss, hypotension, hyponatremia and hyperkalemia amongst adrenal causes of insufficiency). The diagnosis should be considered in case of pituitary disease or a state of shock. Treatment should be commenced immediately without waiting for confirmation from biochemical tests, which rely on cortisol level at 8am (expected to be low) and on ACTH level (expected to be high in the case of primary adrenal insufficiency). If these tests are inconclusive, a Synacthen test should be carried out. The threshold limits are provided as a guide. Low plasma cortisol and normal to low plasma ACTH indicates a pituitary origin for the deficiency. In this situation, the Synacthen test can give a false normal result, and if this adrenal insufficiency is strongly suspected, an insulin hypoglycemia test or metyrapone (Metopirone®) test should be carried out. In children younger than 2yr, hypoglycemia, dehydration and convulsions are frequently observed and in young girls, virilization is suspect of congenital adrenal hyperplasia . The circadian rhythm of cortisol is not present until after 4months of age and the Synacthen test is the only one that is feasible. In children older than 2yrs, the signs and diagnostic methods are the same as in the adult. Cessation of corticosteroid treatment is a frequent circumstance however there is little published data and no evidence for definitive guidelines. After ceasing a short period of corticosteroid treatment, patient education is all that is required. After longer treatment, consensus leaves the choice up to the physician, between educating the patient and prescribing hydrocortisone in case of stress, or prescribing low daily dose hydrocortisone and evaluating the ACTH axis over time until normal function is recovered.

      PubDate: 2017-12-01T11:13:21Z
      DOI: 10.1016/j.ando.2017.10.005
  • Group 4: Replacement therapy for adrenal insufficiency
    • Authors: Frédéric Castinetti; Laurence Guignat; Claire Bouvattier; Dinane Samara-Boustani; Yves Reznik
      Abstract: Publication date: Available online 21 November 2017
      Source:Annales d'Endocrinologie
      Author(s): Frédéric Castinetti, Laurence Guignat, Claire Bouvattier, Dinane Samara-Boustani, Yves Reznik

      PubDate: 2017-12-01T11:13:21Z
      DOI: 10.1016/j.ando.2017.10.007
  • Comité éditorial
    • Abstract: Publication date: October 2017
      Source:Annales d'Endocrinologie, Volume 78, Supplement 1

      PubDate: 2017-12-01T11:13:21Z
  • Droits d'auteur
    • Abstract: Publication date: October 2017
      Source:Annales d'Endocrinologie, Volume 78, Supplement 1

      PubDate: 2017-12-01T11:13:21Z
  • Nouveautés dans l’hyperplasie congénitale des
    • Authors: Dumeige Bouvattier
      Abstract: Publication date: October 2017
      Source:Annales d'Endocrinologie, Volume 78, Supplement 1
      Author(s): L. Dumeige, C. Bouvattier, M. Lombès
      L’hyperplasie congénitale des surrénales est une maladie autosomique récessive due à une anomalie de fonction des enzymes de la stéroïdogenèse surrénalienne dont la plus fréquente est le déficit en 21-hydroxylase. Les formes sévères de la maladie dites formes classiques sont caractérisées d’une part par un déficit en cortisol, et parfois en aldostérone, qui peut mettre en jeu le pronostic vital des nouveau-nés atteints, et d’autre part par une augmentation de synthèse des androgènes surrénaliens aboutissant à la virilisation des organes génitaux externes des nouveau-nés filles, puis à des signes d’hyperandrogénie au cours de l’enfance et de l’adolescence. Le dépistage néonatal a permis une diminution de la morbi-mortalité de la maladie en période néonatale chez les garçons, mais ses performances pourraient être encore largement optimisées par l’ajustement des techniques de dosages ou des biomarqueurs utilisés. Le diagnostic génétique de cette affection est rendu difficile par la grande hétérogénéité génétique de la région 6p21.3 qui contient le gène CYP21A2. Les techniques de séquençage de nouvelle génération devraient faciliter le diagnostic. Le diagnostic prénatal est désormais possible dès 6 semaines de grossesse mais le traitement prénatal reste controversé dans l’attente des résultats de cohortes prospectives évaluant son impact au long cours. Les thérapeutiques classiques ayant des limites, de nouveaux traitements sont actuellement en cours de développement afin de permettre un meilleur contrôle de la synthèse des androgènes et une substitution respectant le rythme physiologique de sécrétion du cortisol, et limitant les complications à long terme. Congenital adrenal hyperplasia is an autosomal recessive disease due to functional abnormalities of adrenal steroid enzymes. The most common form of the disease is due to a 21-hydroxylase deficiency. The classical forms (most severe) are characterized by a deficiency in cortisol and sometimes in aldosterone, which may compromise the vital prognosis of neonates, and by an increase in androgen synthesis, leading to the virilization of girls’ external genitalia at birth, followed by clinical signs of hyperandrogenism during childhood and adolescence. Neonatal screening has improved management and reduced morbidity and mortality in the neonatal period, but its performance could be broadly optimised by adjusting the assay techniques or the biomarkers used. The genetic diagnosis is difficult owing to the large genetic heterogeneity of the 6p21.3 region, which contains the CYP21A2 gene, especially with respect to the use of new-generation techniques of sequencing. Prenatal diagnosis is now possible as early as 6 weeks of gestation, but prenatal treatment remains controversial, awaiting results from prospective cohorts evaluating its long-term impact. Since conventional therapies have limitations, new therapies are currently being developed to allow better control of androgen synthesis and a substitutive treatment that respects the physiological rhythm of cortisol secretion, which would limit the development of long-term complications.

      PubDate: 2017-12-01T11:13:21Z
  • L’année en lipidologie : de nouvelles perspectives
    • Authors: Farnier
      Abstract: Publication date: September 2017
      Source:Annales d'Endocrinologie, Volume 78, Issue 4
      Author(s): M. Farnier
      De nouvelles approches thérapeutiques sont en développement en lipidologie. L’une des classes les plus importantes est celle des inhibiteurs de PCSK9, protéine qui régule l’activité des LDL récepteurs. Les anticorps monoclonaux humains alirocumab et évolocumab diminuent de 50–60 % le taux de LDL-cholestérol et les premiers résultats des essais de prévention cardiovasculaire ont été présentés cette année. Une inhibition de la synthèse de PCSK9 par un ARN interférent, l’inclisiran, est également en développement. Des espoirs proviennent aussi des inhibiteurs de la protéine 3 de type angiopoiétine, anticorps monoclonaux qui diminuent la production des LDL par les lipoprotéines riches en triglycérides. De plus des oligonucléotides antisens de l’apoCIII (volanesorsen) sont très efficaces pour abaisser les triglycérides avec des résultats encourageants dans le cadre des hyperchylomicronémies familiales. Enfin, des antisens de l’apolipoprotéine(a) sont en études cliniques. Parmi les stratégies agissant plus spécifiquement sur les HDL, plusieurs échecs successifs sont intervenus avec des HDL reconstituées, mais il reste encore en développement certains inhibiteurs de la CETP. Par ailleurs, un nouvel activateur PPARa plus sélectif, le pémafibrate, est testé chez le patient diabétique pour agir sur la dyslipidémie athérogène de ces patients et deux essais de prévention cardiovasculaire utilisant des acides gras oméga 3 en association aux statines sont en cours. Au total, de nombreux espoirs existent pour agir de façon plus spécifique sur des cibles modulant le métabolisme des lipoprotéines plasmatiques Le véritable défi auquel se heurtera la nouvelle génération d’agents lipido-régulateurs sera fort probablement l’accessibilité à l’ère d’une médecine de précision.

      PubDate: 2017-09-24T08:25:58Z
  • Génétique et génomique de l’hyperaldostéronisme
    • Authors: M.C. Zennaro; F.L. Fernandes-Rosa Boulkroun
      Abstract: Publication date: September 2017
      Source:Annales d'Endocrinologie, Volume 78, Issue 4
      Author(s): M.C. Zennaro, F.L. Fernandes-Rosa, S. Boulkroun
      L’hyperaldostéronisme primaire (HAP) est la forme la plus fréquente d’hypertension artérielle secondaire. Il est dû, dans la plupart des cas, à un adénome produisant de l’aldostérone (APA, ou adénome de Conn) ou à une hyperplasie bilatérale des surrénales (BAH). Bien que l’HAP soit le plus souvent sporadique, la maladie peut se manifester également dans un contexte familial. Des avancés récentes en génétique et génomique ont permis des avancées majeures dans notre compréhension de la pathogenèse de l’HAP. Des mutations somatiques récurrentes dans des gènes codants pour des canaux ioniques (KCNJ5, CACNA1D) et des ATPases (ATP1A1, ATP2B3) ainsi que dans le gène CTNNB1, ont été identifiées dans plus de 50 % des APA. Des mutations constitutionnelles de KCNJ5 ont été identifiées chez des patients atteints d’hyperaldostéronisme familial de type 3 et des mutations de novo de CACNA1D ont été retrouvées dans une maladie rare associant un HAP et un syndrome neurologique complexe avec crises épileptiques. Plus récemment, des mutations du gène CACNA1H, codant pour un canal calcique voltage-dépendant de type T, ont été identifiées dans une nouvelle forme d’HAP familial chez l’enfant, mais peuvent également être retrouvées dans des formes plus communes d’HAP. Cette présentation résumera nos connaissances actuelles sur les bases génétiques et génomiques de l’HAP et discutera des mécanismes pathogéniques aboutissant à la formation d’un adénome et à la production autonome d’aldostérone. Nous allons également discuter de l’hétérogénéité des APA et des formes familiales et des conséquences de cette hétérogénéité sur la prise en charge des patients.

      PubDate: 2017-09-24T08:25:58Z
  • Expanding the cause of hypopituitarism
    • Authors: Popovic
      Abstract: Publication date: September 2017
      Source:Annales d'Endocrinologie, Volume 78, Issue 4
      Author(s): V. Popovic
      Hypopituitarism is defined as one or more pituitary hormone deficits due to a lesion in the hypothalamic-pituitary region. By far, the most common cause of hypopituitarism associated with sellar mass is pituitary adenoma. The less common and unusual causes of hypopituitarism are always challenging, and there is a long delay in arriving at the diagnosis. However, a high index of suspicion is needed when patients present with a history of cranial irradiation, head trauma, vascular injury, cancer treated with specific immune therapy causing hypophysitis, history of systemic diseases and bacterial, tuberculosis, viral, fungal and parasitic infections. Once suspected, the diagnosis can be confirmed with pituitary function tests and imaging. The pattern of pituitary hormone deficiencies depends on the nature of the underlying pathological process. Hypopituitarism may be permanent in some instances or transitory in other necessitating repeated assessment. It is unclear who and how often to screen, but certainly, a lengthy follow-up is needed. Identification of population at risk of hypopituitarism is important because many in the community may have untreated hypopituitarism with increased uncapacitation while optimal hormonal replacement may significantly improve their quality of life and life expectancy.

      PubDate: 2017-09-24T08:25:58Z
  • La TEP-DOPA dans l’exploration des tumeurs endocrines en 2017
    • Authors: Ansquer
      Abstract: Publication date: September 2017
      Source:Annales d'Endocrinologie, Volume 78, Issue 4
      Author(s): C. Ansquer
      La L-3,4-dihydroxy-phenylalanine (DOPA) est un analogue d’acide aminé radiomarqué au Fluor 18 utilisé en imagerie TEP avec une AMM obtenue en France en 2006. Son intérêt dans l’exploration des TNE repose sur les capacités de ces tumeurs à stocker, accumuler et décarboxyler les précurseurs des amines biogènes. Au cours de la présentation, seront exposées les principales indications de la TEP-DOPA pour l’exploration des TNE et sa valeur ajoutée par rapport aux autres explorations scintigraphiques. La TEP-DOPA est un examen de caractérisation neuroendocrine très performant pour le bilan lésionnel : – des TNE à sécrétion sérotoninergique, en particulier de l’intestin grêle, à proposer en première intention pour un bilan d’extension exhaustif ; – des PGL/PHEO, à proposer en première intention pour l’exploration des PGL de la tête et du cou et les PGL sporadiques ; – des CMT, avec réalisation d’acquisitions précoces ; – des TNE bronchopulmonaires et à la recherche de la tumeur primitive occulte, en complément des autres explorations scintigraphiques ; – des insulinomes néonataux. Ce traceur est moins performant pour l’exploration des TNE pancréatiques de l’adulte avec une fixation physiologique pancréatique qui peut être intense. Il ne s’agit pas d’un agent théranostique et sa valeur pronostique n’a pas été rapportée. La TEP-DOPA s’avère dans bien des cas complémentaire de la TEP-FDG et de l’imagerie aux analogues de la somatostatine, examens qui demeurent incontournables pour caractériser les lésions, prédire leur évolutivité et orienter la prise en charge thérapeutique (en particulier avant radiothérapie interne vectorisée).

      PubDate: 2017-09-24T08:25:58Z
  • Rôle de la barrière hématoencéphalique dans la régulation de
           l’homéostasie énergétique
    • Authors: Prevot
      Abstract: Publication date: September 2017
      Source:Annales d'Endocrinologie, Volume 78, Issue 4
      Author(s): V. Prevot
      La survie d’un organisme repose sur sa capacité à communiquer de manière rapide, efficace et reproductible avec les réseaux de cellules qui contrôlent la prise alimentaire et l’homéostasie énergétique dans le cerveau. Pour cela, les facteurs hormonaux reflétant l’état de faim ou de satiété d’un individu doivent traverser la barrière hématoencéphalique pour atteindre les neurones effecteurs. Un défaut dans ce processus conduit invariablement à une perturbation du contrôle de la masse pondérale. Nous discutons ici de travaux récents montrant qu’un type particulier de cellules gliales nommées tanycytes joue un rôle important dans ce processus. Les corps cellulaires de ces cellules tapissent le plancher du troisième ventricule et leurs extensions podales entrent en contact avec la surface piale du cerveau. Les tanycytes hypothalamiques régulent la plasticité de la barrière hématoencéphalique en fonction de l’état nutritionnel de l’individu, et sont aussi impliqués dans la capture des signaux métaboliques tels que la leptine dans la circulation sanguine et leur transport vers le liquide céphalorachidien. Le blocage du transport des facteurs métaboliques périphériques dans le cerveau à travers les tanycytes pourrait constituer un événement physiopathologique conduisant à l’hormonorésistance centrale chez les patients obèses.

      PubDate: 2017-09-24T08:25:58Z
  • Interventions to improve β-cell mass and function
    • Authors: Prosenjit Mondal; Amit Prasad; Khyati Girdhar
      Abstract: Publication date: Available online 1 September 2017
      Source:Annales d'Endocrinologie
      Author(s): Prosenjit Mondal, Amit Prasad, Khyati Girdhar
      Diabetes mellitus (T2DM) has become an epidemiologically important disease worldwide and is also becoming a great matter of concern due to the effects associated with it like: high morbidity, elevated health care cost and shortened life span. T2DM is a chronic metabolic disease characterized by insulin resistance as well as β-cell dysfunction. It is widely accepted that in the face of insulin resistance, euglycemia can be maintained by increase in pancreatic β-cell mass and insulin secretion. This compensation is largely due to enhanced secretion of insulin by the β-cell mass, which is present initially, and thereby subsequent increases in β-cell mass provide additional insulin secretion. However, the mechanism by which β-cell anatomical plasticity and functional plasticity for insulin secretion is coordinated and executed in different physiological and pathophysiological states is complex and has been poorly understood. As the incidence of T2DM continues to increase at an alarming rate, it is becoming imperative to shift the research focus towards the β-cell physiology where identification of novel pathways that influence the β-cell proliferation and/or contribute to increase insulin secretion has the potential to lead to new therapies for preventing or delaying onset of disease.

      PubDate: 2017-09-06T05:04:25Z
      DOI: 10.1016/j.ando.2016.11.002
  • V. Aboyans et al. in response to the article by M. Helfre et al.:
           Usefulness of a systematic screening of carotid atherosclerosis in
           asymptomatic people with type 2 diabetes for cardiovascular risk
           reclassification. Ann Endocrinol (Paris). 2017;78:14–19
    • Authors: Victor Aboyans; Ileana Desormais; Lucile Jarlan; Marie-Pierre Teissier; Philippe Lacroix
      Abstract: Publication date: Available online 1 September 2017
      Source:Annales d'Endocrinologie
      Author(s): Victor Aboyans, Ileana Desormais, Lucile Jarlan, Marie-Pierre Teissier, Philippe Lacroix

      PubDate: 2017-09-06T05:04:25Z
      DOI: 10.1016/j.ando.2017.05.003
  • Pheochromocytoma during pregnancy: Case report and review of recent
    • Authors: Laura Orioli; Frederic Debiève; Julian Donckier; Michel Mourad; Fernande Lois; Dominique Maiter
      Abstract: Publication date: Available online 1 September 2017
      Source:Annales d'Endocrinologie
      Author(s): Laura Orioli, Frederic Debiève, Julian Donckier, Michel Mourad, Fernande Lois, Dominique Maiter

      PubDate: 2017-09-06T05:04:25Z
      DOI: 10.1016/j.ando.2017.05.004
  • Carbimazole embryopathy
    • Authors: Fayçal El Guendouz; Nabil Hammoune; Abdelaziz Hommadi; Hicham Zerhouni; Hicham Baizri
      Abstract: Publication date: Available online 1 September 2017
      Source:Annales d'Endocrinologie
      Author(s): Fayçal El Guendouz, Nabil Hammoune, Abdelaziz Hommadi, Hicham Zerhouni, Hicham Baizri

      PubDate: 2017-09-06T05:04:25Z
      DOI: 10.1016/j.ando.2016.01.011
  • 34e Congrès SFE Poitiers 2017
    • Authors: Bertrand Cariou; Philippe Caron
      Abstract: Publication date: Available online 12 August 2017
      Source:Annales d'Endocrinologie
      Author(s): Bertrand Cariou, Philippe Caron

      PubDate: 2017-08-18T06:29:32Z
      DOI: 10.1016/j.ando.2017.07.736
  • Reconsidering olfactory bulb magnetic resonance patterns in Kallmann
    • Authors: Thomas Hacquart; Aïcha Ltaief-Boudrigua; Cécile Jeannerod; Salem Hannoun; Gérald Raverot; Michel Pugeat; Aude Brac de la Perriere; Véronique Lapras; Frédérique Nugues; Catherine Dode; Francois Cotton
      Abstract: Publication date: Available online 12 August 2017
      Source:Annales d'Endocrinologie
      Author(s): Thomas Hacquart, Aïcha Ltaief-Boudrigua, Cécile Jeannerod, Salem Hannoun, Gérald Raverot, Michel Pugeat, Aude Brac de la Perriere, Véronique Lapras, Frédérique Nugues, Catherine Dode, Francois Cotton
      Objective The aim of this retrospective study was to perform magnetic resonance imaging assessment of olfactory pathway and skull base abnormalities in Kallmann syndrome (KS) patients with hypogonadotropic hypogonadism and olfaction disorder. Methods Magnetic resonance brain patterns were retrospectively studied in 19 patients clinically classified as KS. Qualitative assessment of olfactory bulb region comprised bulb atrophy and rectus and medial orbital gyrus ptosis; quantitative assessment measured olfactory fossa depth and width, sulcus depth and ethmoid angle. Results were compared to an age- and sex-matched control population (n =19) with no impairment in the region of interest. Sixteen of the 19 KS patients were genetically screened for mutations associated with KS. Results On the above qualitative criteria, 15 of the 19 patients presented either unilateral (n =2) or bilateral (n =13) olfactory bulb agenesis; 16 showed tract agenesis and 16 showed gyrus malformation (ptosis or absence). On the quantitative criteria, 18 of the 19 patients showed abnormal sulcus depth and/or olfactory fossa malformation and/or abnormal ethmoid angle. Conclusion The presence of malformation abnormalities in the olfactory fossae of 18 of the 19 patients appears to be a key factor for etiological diagnosis of hypogonadotropic hypogonadism, and should enable targeted study of genes involved in KS.

      PubDate: 2017-08-18T06:29:32Z
      DOI: 10.1016/j.ando.2016.12.003
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