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Publisher: Elsevier   (Total: 3030 journals)

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Showing 1 - 200 of 3030 Journals sorted alphabetically
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 20, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 16, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 79, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 22, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 27, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 4)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 5, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 303, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 3)
Acta Biomaterialia     Hybrid Journal   (Followers: 25, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription  
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 196, SJR: 3.683, h-index: 202)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.615, h-index: 21)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 9, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription   (Followers: 1)
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 3, SJR: 0.311, h-index: 16)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 2)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 21, SJR: 1.365, h-index: 73)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 5, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 4)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.383, h-index: 19)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 2)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 5, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 4, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 4)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 5)
Additive Manufacturing     Hybrid Journal   (Followers: 7, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 20)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 120, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 16, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 8, SJR: 0.299, h-index: 15)
Advances in Agronomy     Full-text available via subscription   (Followers: 15, SJR: 2.071, h-index: 82)
Advances in Anesthesia     Full-text available via subscription   (Followers: 24, SJR: 0.169, h-index: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 3)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 6, SJR: 1.054, h-index: 35)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 10, SJR: 0.801, h-index: 26)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 21, SJR: 1.286, h-index: 49)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
Advances in Botanical Research     Full-text available via subscription   (Followers: 3, SJR: 0.619, h-index: 48)
Advances in Cancer Research     Full-text available via subscription   (Followers: 26, SJR: 2.215, h-index: 78)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 0.9, h-index: 30)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 2.139, h-index: 42)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 24, SJR: 0.183, h-index: 23)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 8, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 16, SJR: 0.223, h-index: 22)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 11)
Advances in Digestive Medicine     Open Access   (Followers: 4)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Ecological Research     Full-text available via subscription   (Followers: 39, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 25, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 7)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 38, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 3)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 8)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 41, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 14)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 18, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.497, h-index: 31)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 22)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 33, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 3, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 4)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 4)
Advances in Life Course Research     Hybrid Journal   (Followers: 7, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 8)
Advances in Marine Biology     Full-text available via subscription   (Followers: 16, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 5, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 21)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 10)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 6, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 3)
Advances in Oncobiology     Full-text available via subscription   (Followers: 3)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 20, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 14)
Advances in Pharmacology     Full-text available via subscription   (Followers: 13, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 7, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 4)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 17, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 56)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 1, SJR: 0.1, h-index: 2)
Advances in Space Research     Full-text available via subscription   (Followers: 332, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 7)
Advances in Surgery     Full-text available via subscription   (Followers: 6, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 28, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 14)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 12)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 42, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 5, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 304, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 4, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 7, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 390, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 29, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 36, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access  
Agriculture and Natural Resources     Open Access   (Followers: 1)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 48, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 3, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 9, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 5)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access  
Algal Research     Partially Free   (Followers: 7, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 5, SJR: 0.776, h-index: 35)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 6, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 45, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 5)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 3)
American Heart J.     Hybrid Journal   (Followers: 45, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 47, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 34, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 6, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 14, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 32, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 25, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 31, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 48, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 174, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 51, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 2)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 22, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 23, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 21, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 32, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 13, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 5)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 52, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 3)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 2, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 38, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 154, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 7, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 10)
Anesthésie & Réanimation     Full-text available via subscription  
Anesthesiology Clinics     Full-text available via subscription   (Followers: 21, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access  
Animal Behaviour     Hybrid Journal   (Followers: 143, SJR: 1.907, h-index: 126)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 5, SJR: 1.151, h-index: 83)
Animal Reproduction Science     Hybrid Journal   (Followers: 5, SJR: 0.711, h-index: 78)
Annales d'Endocrinologie     Full-text available via subscription   (SJR: 0.394, h-index: 30)
Annales d'Urologie     Full-text available via subscription  
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (SJR: 0.177, h-index: 13)
Annales de Chirurgie de la Main et du Membre Supérieur     Full-text available via subscription  
Annales de Chirurgie Plastique Esthétique     Full-text available via subscription   (Followers: 2, SJR: 0.354, h-index: 22)
Annales de Chirurgie Vasculaire     Full-text available via subscription   (Followers: 1)

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Journal Cover Annales d'Endocrinologie
  [SJR: 0.394]   [H-I: 30]   [0 followers]  Follow
    
   Full-text available via subscription Subscription journal  (Not entitled to full-text)
   ISSN (Print) 0003-4266
   Published by Elsevier Homepage  [3030 journals]
  • How to recognize Cowden syndrome: A novel PTEN mutation description
    • Authors: Pauline Delannoy; François Guillaume Debray; Alain Verloes; Albert Beckers; Hernan Valdes-Socin
      Abstract: Publication date: Available online 2 March 2017
      Source:Annales d'Endocrinologie
      Author(s): Pauline Delannoy, François Guillaume Debray, Alain Verloes, Albert Beckers, Hernan Valdes-Socin


      PubDate: 2017-03-08T05:17:35Z
      DOI: 10.1016/j.ando.2017.01.001
       
  • Biotin interferes with free thyroid hormone and thyroglobulin, but not TSH
           measurements using Beckman-Access immunoassays
    • Authors: Soo Kyung Lim; Antoine Pilon; Jérôme Guéchot
      Abstract: Publication date: Available online 13 February 2017
      Source:Annales d'Endocrinologie
      Author(s): Soo Kyung Lim, Antoine Pilon, Jérôme Guéchot


      PubDate: 2017-02-16T06:05:44Z
      DOI: 10.1016/j.ando.2016.08.001
       
  • Usefulness of a systematic screening of carotid atherosclerosis in
           asymptomatic people with type 2 diabetes for cardiovascular risk
           reclassification
    • Authors: Marjorie Helfre; Claire Grange; Benjamin Riche; Delphine Maucort-Boulch; Charles Thivolet; Julien Vouillarmet
      Abstract: Publication date: Available online 7 February 2017
      Source:Annales d'Endocrinologie
      Author(s): Marjorie Helfre, Claire Grange, Benjamin Riche, Delphine Maucort-Boulch, Charles Thivolet, Julien Vouillarmet
      Aims Routine screening of carotid atherosclerosis lesions is frequently suggested for people with type 2 diabetes, the presence of a carotid lesion being associated with a significant increase risk for vascular events. However, the impact of this strategy on medical management is not validated. We herein question the usefulness of such screening. Methods We assessed the prevalence and severity of carotid lesions in 337 consecutive people with type 2 diabetes without known cardiovascular disease who underwent a systematic carotid duplex ultrasonography. We analyzed whether the results of duplex ultrasonography allowed reclassification of cardiovascular risk level relative to the most recent international recommendations on diabetes and modified therapy. Results We found that 35.9% of people had no atherosclerotic lesion. Prevalence of carotid stenosis<20%, between 20 and 50% and ≥50% were 32.9%, 28.4% and 2.7% respectively. Regarding the use of statins and LDL-C target, the result of carotid duplex ultrasonography allowed to reclassify respectively 11.8% to 55.2% of the cohort in a higher cardiovascular risk level. For the indication of antiplatelet agent, reclassification in a higher risk level concerned 6.8% of the patients. No subject had an indication of carotid revascularization. Conclusions Carotid atherosclerosis is frequent in asymptomatic people with type 2 diabetes in primary cardiovascular prevention. Screening for carotid atherosclerosis by duplex ultrasonography seems useful to redefine the level of cardiovascular risk.

      PubDate: 2017-02-10T20:09:52Z
      DOI: 10.1016/j.ando.2016.12.001
       
  • Treatment by rituximab on six Grave's ophthalmopathies resistant to
           corticosteroids
    • Authors: Flavien Précausta; Sophie Arsène; Peggy Renoult-Pierre; Boris Laure; Lise Crinière; Pierre-Jean Pisella
      Abstract: Publication date: Available online 6 February 2017
      Source:Annales d'Endocrinologie
      Author(s): Flavien Précausta, Sophie Arsène, Peggy Renoult-Pierre, Boris Laure, Lise Crinière, Pierre-Jean Pisella
      Objectives Graves’ ophthalmopathy occurs in 50% of Graves’ disease cases. Treatment is based on smoking cessation, and control of the euthyroidism and ocular repercussions associated with the disease. The active orbital forms are treated with glucocorticoids. Non-validated therapies have also been recently tested. Rituximab has been effectively used several times to treat corticosteroid-resistant Graves’ ophthalmopathy associated with an optic neuropathy, but its use could be proposed only in inflammatory ophthalmopathies after failure of the corticosteroids. We present six cases treated since early 2012 at the University Hospital Center of Tours, France. Methods Six patients were treated at the University Hospital Center of Tours, France, between September 2012 and April 2014. The patients had a Mourits’ score greater than three after treatment with corticosteroids and/or a severe NOSPECS score and/or orbital inflammation resistant to maximal treatment with intravenous injections of methylprednisolone and an optic neuropathy. They twice received one gram of rituximab by slow intravenous injection two weeks apart. Efficacy was assessed by a decrease of the orbital inflammatory clinical Mourits’ score, and visual acuity and visual field testing. Results The inflammatory score of patients improved and treatment helped to stop the progression of the sequelae due to neuropathy. The orbital inflammatory clinical score, and the visual acuity and visual field improved but orbital decompression was necessary to complete the treatment. Conclusion Rituximab has been used for the treatment of active corticosteroid-resistant Graves’ ophthalmopathies. We also had positive results on patients with visual threat and optic neuropathy, when combined with surgical decompression.

      PubDate: 2017-02-10T20:09:52Z
      DOI: 10.1016/j.ando.2016.12.002
       
  • Stroke disclosing primary aldosteronism: Report on three cases and review
           of the literature
    • Authors: Amina Nasri; Malek Mansour; Zeineb Brahem; Amel Kacem; Ahmed Abou Hassan; Hager Derbali; Meriem Messelmani; Jamel Zaouali; Ridha Mrissa
      Abstract: Publication date: Available online 4 February 2017
      Source:Annales d'Endocrinologie
      Author(s): Amina Nasri, Malek Mansour, Zeineb Brahem, Amel Kacem, Ahmed Abou Hassan, Hager Derbali, Meriem Messelmani, Jamel Zaouali, Ridha Mrissa
      Objectives There is a growing evidence of increased risk of cerebrovascular events in primary aldosteronism (PA). Nevertheless, acute neurologic ailment as presenting feature of PA is uncommon. Our aim is to highlight the diagnosis challenges in stroke unmasking PA and to discuss the underlying physiopathology and management dilemmas. Materials and methods We hereby describe three consecutive rare cases of stroke revealing PA. All patients had brain imaging and thorough biological and morphological assessment to rule out other etiologies of stroke. The diagnosis of primary aldosteronism was established according to the Endocrine Society Clinical Practice Guideline, with a review of the literature on the spectrum of neurologic manifestations in PA. Results We report on three cases, two women and a man, presenting with ischemic or hemorrhagic stroke, of early onset in two of them. All of the reported patients had hypertension and hypokaliemia. This association prompted the assessment of renin angiotensin aldosterone system (RAAS) disclosing PA, which was due to bilateral adenomas in the first one or bilateral adrenal hyperplasia in the two others. All patients refused the surgical option and received spironolactone with recurrence of stroke in one of them due to treatment incompliance. Conclusion Although cerebrovascular events are quite common in PA, their occurrence as initial feature can be misleading. The association of hypokaliemia and refractory hypertension in ischemic or hemorrhagic strokes should prompt an assessment of the RAAS to rule out PA and initiate adequate management as soon as possible in order to avoid further complications.

      PubDate: 2017-02-10T20:09:52Z
      DOI: 10.1016/j.ando.2016.07.993
       
  • Consensus statement on the management of dyslipidaemias in adults
    • Authors: S. Béliard; F. Bonnet; B. Bouhanick; E. Bruckert; B. Cariou; S. Charrière; V. Durlach; P. Moulin; R. Valéro; B. Vergès
      Abstract: Publication date: Available online 12 January 2017
      Source:Annales d'Endocrinologie
      Author(s): S. Béliard, F. Bonnet, B. Bouhanick, E. Bruckert, B. Cariou, S. Charrière, V. Durlach, P. Moulin, R. Valéro, B. Vergès


      PubDate: 2017-01-20T05:24:39Z
      DOI: 10.1016/j.ando.2016.11.001
       
  • Empagliflozin/Linagliptin: Combination therapy in patients with
           type 2 diabetes
    • Authors: Xueying Tan; Jingbo Hu
      Pages: 557 - 562
      Abstract: Publication date: October 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 5
      Author(s): Xueying Tan, Jingbo Hu
      Glyxambi® (empagliflozin/linagliptin) is a fixed-dose, once-daily tablet combining a sodium glucose co-transporter-2 (SGLT2) inhibitor with a dipeptidyl peptidase-4 (DPP-4) inhibitor. Glyxambi® is served as an adjuvant to diet and exercise to improve glycemic control in adults with type 2 diabetes when both empagliflozin and linagliptin are appropriate treatments. Glyxambi® combines 10mg or 25mg empagliflozin with 5mg linagliptin, with different, complementary mechanisms of action to improve glycemic control in patients with type 2 diabetes. Empagliflozin removes glucose through the urine by blocking blood glucose re-absorption in the kidney, and linagliptin exerts glucose-lowering activity by increasing hormones that stimulate the pancreas to produce more insulin and decreasing the levels of glucagon in the circulation. In addition, this combination therapy modestly reduces body weight and blood pressure without significant safety issues.

      PubDate: 2016-10-30T16:57:49Z
      DOI: 10.1016/j.ando.2015.11.003
       
  • Rational and design of an overfeeding protocol in constitutional thinness:
           Understanding the physiology, metabolism and genetic background of
           resistance to weight gain
    • Authors: Yiin Ling; Bogdan Galusca; Jorg Hager; Leonard Feasson; Armand Valsesia; Jacques Epelbaum; Virginie Alexandre; Emma Wynn; Cécile Dinet; Radu Palaghiu; Michel Peoc’h; Yves Boirie; Christophe Montaurier; Bruno Estour; Natacha Germain
      Pages: 563 - 569
      Abstract: Publication date: October 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 5
      Author(s): Yiin Ling, Bogdan Galusca, Jorg Hager, Leonard Feasson, Armand Valsesia, Jacques Epelbaum, Virginie Alexandre, Emma Wynn, Cécile Dinet, Radu Palaghiu, Michel Peoc’h, Yves Boirie, Christophe Montaurier, Bruno Estour, Natacha Germain
      Background Constitutional thinness (CT) is a natural state of underweight (13–17.5kg/m2) without the presence of any eating disorders and abnormal hormonal profile, and with preserved menses in women. We previously conducted a four-week fat overfeeding study showing weight gain resistance in CT women and one of our main results was the identification of an energy gap: a positive energy balance (higher energy intake than energy expenditure). Objective This new overfeeding study is designed to confirm the energy gap and propose mechanistic hypothesis. Design A 2-week overfeeding (daily consumption of one bottle of Renutryl® Booster (600kcal, 30g protein, 72g carbohydrate, 21g fat) on top of the dietary intake) is performed to compare 15 women and men in each CT group (Body Mass Index [BMI]<18.5kg/m2) to their controls (BMI 20–25kg/m2). Bodyweight, food intake, energy expenditure (canopy, calorimetric chamber and Actiheart), body composition (DXA), appetite regulatory hormone profiles after a test meal, proteomics, metabolomics, urinary metabolic profiles, stool microbiome and lipids, fat and muscle transcriptomics are monitored before and after overfeeding. Results and conclusions Data inter-linking will be able to be established with results of this study. The findings could possibly open to therapeutic approaches to help CT patients to gain weight as well as provide a better understanding of energy regulation with regard to treat obesity (resistance to weight loss), a mirror image of CT (resistance to weight gain).

      PubDate: 2016-10-30T16:57:49Z
      DOI: 10.1016/j.ando.2016.06.001
       
  • Management of Graves’ disease during pregnancy in the
           Poitou-Charentes Region
    • Authors: Claire Hawken; Mélie Sarreau; Marc Bernardin; Anne-Christine Delcourt; Anne Muller; Guy Lefort; Patrice Pernollet; Richard Marechaud
      Pages: 570 - 577
      Abstract: Publication date: October 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 5
      Author(s): Claire Hawken, Mélie Sarreau, Marc Bernardin, Anne-Christine Delcourt, Anne Muller, Guy Lefort, Patrice Pernollet, Richard Marechaud
      Graves’ disease (GD) during pregnancy involves risks for the mother, foetus and neonate. Objective To compile an inventory of the clinical practices regarding the management of GD during pregnancy in the Poitou-Charentes region of France. This was a retrospective, multicentre study covering the period 2005 to 2012. Ninety-five pregnancies were reviewed: 14 GD diagnosed during pregnancy, 24 GD already treated with synthetic antithyroid drugs (SAT) prior to pregnancy, 25 GD in remission before pregnancy and 32 GD who had undergone thyroidectomy prior to pregnancy. In patients under SAT and/or with TSH receptor antibody levels (TRAb)>3N at the 2nd (T2) and/or 3rd trimester (T3) of pregnancy, a foetal thyroid ultrasound (FTU) was performed in 18/32 cases and neonatal thyroid screening (NTS) in 14/20 cases. One case of foetal hyperthyroidism, two of neonatal hyperthyroidism and three of foetal hypothyroidism (including one neonatal hypothyroidism) were observed. Propylthiouracil was the preferred treatment prescribed, whatever the trimester. A congenital malformation was observed in 4/19 foetuses exposed to carbimazole during the 1st trimester (T1). In operated patients, TSH levels were>2.5mIU/L during T1 in 23/32 cases, while TRAb were not assayed during pregnancy in 12/32 cases. The management of GD during pregnancy could be improved by adjusting SAT therapy during its course, titrating levothyroxine prior to conception and in early pregnancy in thyroidectomised patients, and a more targeted use of FTU during T2 and T3 and of neonatal thyroid screening.

      PubDate: 2016-10-30T16:57:49Z
      DOI: 10.1016/j.ando.2016.03.003
       
  • Efficacy and safety of mitotane in the treatment of adrenocortical
           carcinoma: A retrospective study in 34 Belgian patients
    • Authors: Dominique Maiter; Marie Bex; Laurent Vroonen; Guy T'Sjoen; Thierry Gil; Camille Banh; Rita Chadarevian
      Pages: 578 - 585
      Abstract: Publication date: October 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 5
      Author(s): Dominique Maiter, Marie Bex, Laurent Vroonen, Guy T'Sjoen, Thierry Gil, Camille Banh, Rita Chadarevian
      Objectives Evaluation of patient characteristics and mitotane use in the treatment of adrenocortical carcinoma (ACC) over a 4-year period in Belgium. Material and methods This was a multicentre retrospective review of the outcome of 34 patients treated with mitotane for ACC during the period [01/2008–12/2011] (12 diagnosed before and 22 diagnosed during the study period) and evaluated up to 06/2013. Results Patient and tumour characteristics were consistent with those generally described for ACC. Mean age at diagnosis was 46.5 years, most patients were female (62%), had functioning ACC (65%) and advanced tumours (ENSAT stages III or IV: 82%). Therapeutic mitotane plasma levels (14–20 mg/L) were achieved at least once in 70% of the cohort, after a median of 4 months, and were maintained for more than 2 months in 61% of evaluable patients. Mitotane-related adverse effects were observed in 66% of patients, were never serious, and included gastrointestinal, neurological, neuropsychological, hormonal, dermatologic and metabolic effects. Most patients (88%) discontinued mitotane, mainly due to tumour progression. Multivariate analysis showed that ENSAT stage was a prognostic factor for overall (OS) and disease-free survival (DFS); OS was also influenced independently by achievement of therapeutic mitotane plasma levels for at least two consecutive months. Conclusion Patient and tumour characteristics were consistent with previously published data. OS and DFS were mostly influenced by ENSAT stage at diagnosis. Achieving therapeutic levels of mitotane for at least two consecutive months seemed to positively influence OS, but such levels were not reached or sustained in some patients.

      PubDate: 2016-10-30T16:57:49Z
      DOI: 10.1016/j.ando.2016.02.005
       
  • Serum fibroblast growth factor 21 concentrations in type 2 diabetic
           retinopathy patients
    • Authors: Alireza Esteghamati; Alireza Momeni; Ali Abdollahi; Amirhossein Khandan; Mohsen Afarideh; Sina Noshad; Manouchehr Nakhjavani
      Pages: 586 - 592
      Abstract: Publication date: October 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 5
      Author(s): Alireza Esteghamati, Alireza Momeni, Ali Abdollahi, Amirhossein Khandan, Mohsen Afarideh, Sina Noshad, Manouchehr Nakhjavani
      Aims/purpose Fibroblast growth factor 21 (FGF21) is a major metabolic regulator in the body that has been shown to be elevated in a number of metabolic disturbances including type 2 diabetes mellitus (T2DM) and the metabolic syndrome. However, little is known regarding the circulating levels of FGF21 in type 2 diabetic retinopathy (T2DR) and its association with the severity of the condition. Methods In a cross-sectional setting, 142 individuals, consisting of (1) T2DM patients without T2DR, (2) T2DM patients with T2DR, and (3) healthy control subjects were recruited for this study. Various clinical and biochemical parameters were assessed and entered for analysis. Results Serum FGF21 levels were significantly elevated in T2DM subjects without retinopathy (103.50 [75.75] pg/mL) compared with healthy controls (99.00 [126.75] pg/mL). Circulating FGF21 levels were comparable across different stages of T2DR (233.00 [109.00] for nonproliferative type 2 diabetic retinopathy [NPT2DR] vs. 215.00 [122.00] for proliferative type 2 diabetic retinopathy [PT2DR] groups, P =361). FGF21, triglycerides, and duration of diabetes mellitus were significantly associated with T2DM in baseline models. However, after adjustment for potential confounders, in the final multivariate model, FGF21 emerged as the only significant factor associated with T2DM (OR=13.772, 95% CI=3.062–61.948, P =001). Conclusions Serum FGF21 concentrations are markedly elevated in patients with T2RN. The association between FGF21 and T2DR appears to be independent of the effects of potential confounding variables. These findings may suggest FGF21 as a novel surrogate diagnostic biomarker in initial stages of T2DR (particularly with FGF21 values above 135.5pg/mL).

      PubDate: 2016-10-30T16:57:49Z
      DOI: 10.1016/j.ando.2016.01.005
       
  • Low vitamin D3 and high anti-Müllerian hormone serum levels in the
           polycystic ovary syndrome (PCOS): Is there a link'
    • Authors: Hélène Cappy; Paolo Giacobini; Pascal Pigny; Aude Bruyneel; Maryse Leroy-Billiard; Didier Dewailly; Sophie Catteau-Jonard
      Pages: 593 - 599
      Abstract: Publication date: October 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 5
      Author(s): Hélène Cappy, Paolo Giacobini, Pascal Pigny, Aude Bruyneel, Maryse Leroy-Billiard, Didier Dewailly, Sophie Catteau-Jonard
      Objectives Low vitamin D serum level has been reported in women with polycystic ovary syndrome (PCOS) compared to controls. A few in vitro studies showed that the bioactive form of vitamin D is able to modulate the expression of the anti-Müllerian hormone (AMH) gene. However, in vivo studies failed to demonstrate clearly whether low vitamin D3 serum level is involved in the AMH excess of PCOS. This prospective study evaluates serum vitamin D3 and AMH levels in women with PCOS and in controls, before and after vitamin D supplementation. Materials and methods Among vitamin D deficient patients, 23 patients with PCOS were compared to 27 women with normal ovarian reserve (NOR). The vitamin D deficient patients received a vitamin D supplementation according to the depth of their insufficiency. For the 23 patients with PCOS and the 27 controls, serum AMH assay and serum calciotropic hormone assays [25-hydroxyvitamin D (25[OH]D), 1,25 dihydroxyvitamin D (1,25[OH]2D) and parathyroid hormone (PTH)] were performed before and after supplementation. Results Serum 25(OH)D levels before treatment were statistically lower in PCOS women than in NOR patients (P <0.05), even after adjustment for BMI, age and AMH level, but not after adjustment for waist circumference measurement. No difference in the serum AMH levels before and after treatment was observed neither in PCOS patients nor in NOR patients. In both groups, 25(OH)D serum levels were not related to serum AMH levels, serum 1,25(OH)2D and serum PTH levels, before and after treatment. Conclusion We found no evidence that serum calciotropic hormones are linked to circulating AMH levels, particularly in PCOS.

      PubDate: 2016-10-30T16:57:49Z
      DOI: 10.1016/j.ando.2016.02.001
       
  • Hyperparathyroidism in octogenarians: A plea for ambulatory minimally
           invasive surgery under local anesthesia
    • Authors: Stéphanie Li Sun Fui; Philippe Bonnichon; Nicolas Bonni; Thierry Delbot; Jean Pascal André; Joëlle Pion-Graff; Jean-Louis Berrod; Marine Fontaine; Catherine Brunaud; Nicolas Cocagne
      Pages: 600 - 605
      Abstract: Publication date: October 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 5
      Author(s): Stéphanie Li Sun Fui, Philippe Bonnichon, Nicolas Bonni, Thierry Delbot, Jean Pascal André, Joëlle Pion-Graff, Jean-Louis Berrod, Marine Fontaine, Catherine Brunaud, Nicolas Cocagne
      Background With the current aging of the world's population, diagnosis of primary hyperparathyroidism is being reported in increasingly older patients, with the associated functional symptomatology exacerbating the vicissitudes of age. This retrospective study was designed to establish functional improvements in older patients following parathyroid adenomectomy under local anesthesia as outpatient surgery. Materials and methods Data were collected from 53 patients aged 80 years or older who underwent a minimally invasive parathyroid adenomectomy. All patients underwent a preoperative ultrasound, scintigraphy, and were monitored for the effectiveness of the procedure according to intra- and postdosage of parathyroid hormone (PTH) at 5min, 2h and 4h. Results Mean preoperative serum calcium level was 2.8mmol/L (112mg/L) and mean PTH was 180pg/ml. Thirty-eight patients were operated under local anesthesia using minimally invasive surgery and 18 patients were operated under general anesthesia. In 26 cases, the procedure was planned on an outpatient basis but could only be carried out in 21 patients. Fifty-one patients had normal serum calcium and PTH levels during the immediate postoperative period. Two patients were reoperated under general anesthesia, since immediate postoperative PTH did not return to normal. Four patients died due to reasons unrelated to hyperparathyroidism. Five patients were lost to follow-up six months to two years postsurgery. Of the 44 patients (83%) with long-term monitoring for PTH, none had recurrence of biological hyperparathyroidism. Excluding the three asymptomatic patients, 38 of the 41 symptomatic patients (93%) with long-term follow-up were considering themselves as “improved” or “strongly improved” after the intervention, notably with respect to fatigue, muscle and bone pain. Two patients (4.9%) reported no difference and one patient (2.4%) said her condition had worsened and regretted having undergone surgery. Conclusion In patients 80 years or older, minimally invasive surgery as an outpatient under local anesthesia offered an excellent risk/benefit ratio given its many advantages: simplicity, speed, absence of general anesthesia, ease of monitoring, direct voice control intraoperatively, very low morbidity, effectiveness in treating primary hyperparathyroidism in more than 95% of first intention patients, and the possibility of immediate or delayed recovery in the event of multiglandular disease going unnoticed.

      PubDate: 2016-10-30T16:57:49Z
      DOI: 10.1016/j.ando.2015.10.006
       
  • Correlation between the plasma fibrinogen concentration and coronary heart
           disease severity in Moroccan patients with type 2 diabetes. Prospective
           study
    • Authors: Souad Kotbi; Amal Mjabber; Asma Chadli; Ayoub El Hammiri; Siham El Aziz; Bouchra Oukkache; Hassan Mifdal; Nadia Nourichafi; Nabiha Kamal; Rachida Habbal; Norredine Ghalim; Ahmed Farouqi; Mostafa Kabine
      Pages: 606 - 614
      Abstract: Publication date: October 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 5
      Author(s): Souad Kotbi, Amal Mjabber, Asma Chadli, Ayoub El Hammiri, Siham El Aziz, Bouchra Oukkache, Hassan Mifdal, Nadia Nourichafi, Nabiha Kamal, Rachida Habbal, Norredine Ghalim, Ahmed Farouqi, Mostafa Kabine
      Aim The present study aims at determining the relationship between the plasma fibrinogen concentration and the severity of coronary heart disease in type 2 diabetic patients. Methods Prospective analytical survey, based on a sample of 120 subjects divided in four groups: 30 non diabetic coronary patients (G1), 30 coronary diabetic patients (G2), 30 non-coronary diabetic patients (G3), and 30 healthy subjects (G4). Results The average age was 59.58±7.88 years; female gender predominated by 52.5%. The plasma fibrinogen concentration corresponded to 3.46g/L±0.86 in G1; 3.73g/L±1.11 in G2; 3.06g/L±0.98 in G3 and 2.46g/L±0.51 in G4; with a significant difference between the four groups (P =0.001). The plasma fibrinogen concentration increased in parallel with the cardiovascular risk (P =0.0001); there was also a significant correlation between the plasma fibrinogen concentration and the clinical and para-clinical coronary disease severity (respectively P =0.005 and P =0.0001). A positive correlation between the plasma fibrinogen concentration and hyperglycemia (P =0.035) was found in G4. But no correlation with the lipids parameters, except for the low density-lipoproteins in G3 (P =0.035). Conclusion In the Moroccan population, the plasma fibrinogen concentration was positively and significantly correlated with the coronary heart disease severity.

      PubDate: 2016-10-30T16:57:49Z
      DOI: 10.1016/j.ando.2015.02.004
       
  • Hyperparathyroidism complicating CYP 24A1 mutations
    • Authors: Camille Loyer; Clara Leroy; Arnaud Molin; Marie-Françoise Odou; Damien Huglo; Georges Lion; Olivier Ernst; Maxime Hoffmann; Nicole Porchet; Bruno Carnaille; François Pattou; Marie-Laure Kottler; Marie-Christine Vantyghem
      Pages: 615 - 619
      Abstract: Publication date: October 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 5
      Author(s): Camille Loyer, Clara Leroy, Arnaud Molin, Marie-Françoise Odou, Damien Huglo, Georges Lion, Olivier Ernst, Maxime Hoffmann, Nicole Porchet, Bruno Carnaille, François Pattou, Marie-Laure Kottler, Marie-Christine Vantyghem
      CYP24A1 gene mutations induce infantile hypercalcemia, with high 1,25(OH)2D contrasting with low PTH levels. The adult phenotype is not well known. Two unrelated adult patients were referred for nephrolithiasis, hypertension, hypercalcemia, hypercalciuria, normal 25-OHD levels, and inappropriate PTH levels (22 to 92pg/mL;N: 15–68) suggesting primary hyperparathyroidism, leading to surgery. Hypercalciuria improved despite persistent hypercalcemia, treated with cinacalcet. The ratio 25-OHD3/24-25-(OH)2D3 >100 (N<25) suggested the diagnosis of CYP24A1 mutations which were confirmed through Sanger sequencing. In conclusion, the adult phenotype associated with CYP24A1 mutations can evolve over time from hypercalcemia with suppressed PTH towards hyperparathyroidism with moderately increased PTH level, adenoma and/or slightly increased parathyroid glands. Surgery decreased calciuria and improved kidney function. Cinacalcet was partially effective on hypercalcemia since PTH was inappropriate. This novel phenotype, a phenocopy of hyperparathyroidism, might evolve in few cases towards hyperparathyroidism despite random association of the 2 diseases cannot be excluded.

      PubDate: 2016-10-30T16:57:49Z
      DOI: 10.1016/j.ando.2016.03.002
       
  • Establishment of revised diagnostic cut-offs for adrenal laboratory
           
    • Authors: Véronique Raverot; Caroline Richet; Yves Morel; Gérald Raverot; Françoise Borson-Chazot
      Pages: 620 - 622
      Abstract: Publication date: October 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 5
      Author(s): Véronique Raverot, Caroline Richet, Yves Morel, Gérald Raverot, Françoise Borson-Chazot


      PubDate: 2016-10-30T16:57:49Z
      DOI: 10.1016/j.ando.2016.05.002
       
  • Dramatic change in skin color after bilateral adrenalectomy in Cushing's
           disease
    • Authors: Lucien Marchand; Aurélie Lecus; Marion Lapoirie; Bérénice Segrestin; Gérald Raverot
      Pages: 623 - 624
      Abstract: Publication date: October 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 5
      Author(s): Lucien Marchand, Aurélie Lecus, Marion Lapoirie, Bérénice Segrestin, Gérald Raverot


      PubDate: 2016-10-30T16:57:49Z
      DOI: 10.1016/j.ando.2016.02.002
       
  • 33e Congrès SFE, Bordeaux 2016
    • Authors: Pierre Gourdy; Jacques Young
      Pages: 235 - 236
      Abstract: Publication date: Available online 18 August 2016
      Source:Annales d'Endocrinologie
      Author(s): Pierre Gourdy, Jacques Young


      PubDate: 2016-08-19T20:33:05Z
      DOI: 10.1016/j.ando.2016.07.008
       
  • Imagerie du petit animal : application à l’endocrinologie
    • Authors: C. Lussey-Lepoutre; A. Bellucci; A. Morin; T. Viel; G. Autret; D. Balvay; A. Buffet; N. Burnichon; C. Ottolenghi; A.-P. Gimenez-Roqueplo; B. Tavitian
      First page: 237
      Abstract: Publication date: September 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 4
      Author(s): C. Lussey-Lepoutre, A. Bellucci, A. Morin, T. Viel, G. Autret, D. Balvay, A. Buffet, N. Burnichon, C. Ottolenghi, A.-P. Gimenez-Roqueplo, B. Tavitian
      La médecine factuelle fait appel à des descriptions analytiques réalisées selon des critères scientifiques rigoureux. Idéalement, on veut repérer chez le patient un signe pathognomonique quantifiable ou biomarqueur de la maladie et en suivre les variations sous traitement. Souvent, le biomarqueur nécessite une analyse destructive du tissu vivant. Les techniques d’imagerie proposent un compromis entre la précision de l’information et l’innocuité de la méthode. Idéalement, l’image localise et quantifie un paramètre précis sans modifier l’équilibre physiologique du sujet. L’intérêt de l’imagerie du petit animal est triple : – inventer, tester et optimiser des techniques d’imagerie transposables à l’homme ; – décrire l’histoire naturelle d’une pathologie par une approche non invasive, donc répétable au cours du temps ; – obtenir un biomarqueur non invasif de l’efficacité thérapeutique. Comparée aux techniques in vitro, l’imagerie paye son caractère non invasif par un accroissement de la complexité et du coût des examens. En outre, une modalité d’imagerie ne donne accès qu’à quelques paramètres biologiques à la fois, ce qui est souvent insuffisant. Il est donc important de valider, en amont de la clinique, les nouvelles approches multimodales d’imagerie chez les modèles animaux des pathologies humaines. Dans cet exposé, nous présenterons à partir d’un exemple concret les recherches menées dans notre laboratoire en imagerie multimodale (IRM, imagerie optique et 18FDG-TEP) chez un modèle murin de paragangliomes liés à une mutation du gène SDHB, et le transfert de l’une d’entre elles en clinique humaine.

      PubDate: 2016-09-07T20:10:57Z
      DOI: 10.1016/j.ando.2016.07.011
       
  • Modifications ciblées (editing) du génome par CRISPR-Cas : des
           applications plausibles aux fantasmes
    • Authors: J.-L. Mandel
      First page: 238
      Abstract: Publication date: September 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 4
      Author(s): J.-L. Mandel
      La révolution CRISPR-Cas9 a éclaté dans le monde de la recherche, notamment biomédicale, début 2013, avec un nombre d’articles scientifiques annuels passant de 30 en 2011 à 200 en 2013 et 1100 en 2015, rapportant des développements méthodologiques et des applications très diverses en recherche, et générant des espoirs de développements thérapeutiques et des craintes quant à des modifications incontrôlées et transmissibles du génome humain. J’aborderai successivement : – la courte et étonnante histoire de l’émergence de CRISPR-Cas comme sujet d’étude au départ très confidentiel et limité à la microbiologie (2000–2012) ; – les principes du « genome editing » et les deux modes principaux de mécanismes cellulaires utilisés : la recombinaison homologue, très précise mais dont l’efficacité est très variable et souvent faible, et le « non-homologous end-joining » (NHEJ), et les applications pour la génération de modèles animaux de maladies humaines. – d’autres applications issues du bricolage du système CRISPR-Cas9 telles que la stimulation ou l’inhibition ciblée de l’expression d’un gène ; – quelques perspectives d’applications thérapeutiques pour des maladies génétiques ou virales (sida) et les limites actuelles ; – les aspects éthiques liés à de potentielles modifications transmissibles du génome humain, tout en soulignant le côté totalement fantasmatique de prédictions quant à l’amélioration des possibilités humaines (« homme augmenté »), par exemple capacités intellectuelles ou longévité.

      PubDate: 2016-09-07T20:10:57Z
      DOI: 10.1016/j.ando.2016.07.012
       
  • PET imaging for thyroid cancers: Current status and future directions
    • Authors: Anne-Laure Giraudet; David Taïeb
      Abstract: Publication date: Available online 15 December 2016
      Source:Annales d'Endocrinologie
      Author(s): Anne-Laure Giraudet, David Taïeb
      Positron emission tomography–computed tomography (PET/CT) combines both functional and anatomic information and provides in vivo molecular information on biological processes that can be useful at different steps of evolution of thyroid cancers. 18Fluorodeoxyglucose being highly trapped in rapidly dividing cells makes 18F-FDG-PET recommended in the staging, prognostic evaluation and follow-up of metastatic and/or of poorly differentiated thyroid carcinomas. 18F-FDG PET/CT can help in the localization of persistent/recurrent disease. However, its sensitivity depends widely on tumor burden and histology. Iodine 124 (124I) is currently under evaluation for diagnosis and pretherapeutic dosimetry planning. PET/CT using 18F-FDOPA is the most sensitive radiopharmaceutical for localizing persistent/recurrent medullary thyroid carcinoma (MTC). However, its sensitivity depends on calcitonin levels, with a threshold value of around 150pg/mL. 18F-FDG PET/CT can also be used in MTC with short calcitonin or CEA doubling time.

      PubDate: 2016-12-19T05:25:20Z
      DOI: 10.1016/j.ando.2016.10.002
       
  • Hemorrhagic pheochromocytoma presenting as severe hypertension with
           myocardial infarction
    • Authors: Ana B. Mañas-Martínez; Ana L. Medrano-Navarro; Esperanza Aguillo-Gutiérrez
      Abstract: Publication date: Available online 15 December 2016
      Source:Annales d'Endocrinologie
      Author(s): Ana B. Mañas-Martínez, Ana L. Medrano-Navarro, Esperanza Aguillo-Gutiérrez


      PubDate: 2016-12-19T05:25:20Z
      DOI: 10.1016/j.ando.2016.10.004
       
  • Partial hypopituitarism in a female patient with a 45,X/46,XY mosaicism
    • Authors: Ibtissem Oueslati; Lilia Kraoua; Karima Khiari; Ridha Mrad; Néjib Ben Abdallah
      Abstract: Publication date: Available online 14 December 2016
      Source:Annales d'Endocrinologie
      Author(s): Ibtissem Oueslati, Lilia Kraoua, Karima Khiari, Ridha Mrad, Néjib Ben Abdallah


      PubDate: 2016-12-19T05:25:20Z
      DOI: 10.1016/j.ando.2016.09.003
       
  • Relative contribution of muscle and liver insulin resistance to
           dysglycemia in postmenopausal overweight and obese women: A MONET group
           study
    • Authors: Belinda Elisha; Emmanuel Disse; Katherine Chabot; Nadine Taleb; Denis Prud’homme; Sophie Bernard; Rémi Rabasa-Lhoret; Jean-Philippe Bastard
      Abstract: Publication date: Available online 5 December 2016
      Source:Annales d'Endocrinologie
      Author(s): Belinda Elisha, Emmanuel Disse, Katherine Chabot, Nadine Taleb, Denis Prud’homme, Sophie Bernard, Rémi Rabasa-Lhoret, Jean-Philippe Bastard
      Objectives The relative contribution of muscle and liver insulin resistance (IR) in the development of dysglycemia and metabolic abnormalities is difficult to establish. The present study aimed to investigate the relative contribution of muscle IR vs. liver IR to dysglycemia in non-diabetic overweight or obese postmenopausal women and to determine differences in body composition and cardiometabolic indicators associated with hepatic or muscle IR. Material and methods Secondary analysis of 156 non-diabetic overweight or obese postmenopausal women. Glucose tolerance was measured using an oral glucose tolerance test. Whole-body insulin sensitivity (IS) was determined as glucose disposal rate during a euglycemic-hyperinsulinemic clamp. Muscle and liver IR have been calculated using Abdul-Ghani et al. OGTT-derived formulas. Participant's body compositions as well as cardiometabolic risk indicators were also determined. Results Overall, 57 (36.5%) of patients had dysglycemia, among them 25 (16.0%); 21 (13.5%); 11 (7.1%) had impaired fasting glycemia, impaired glucose tolerance and combined glucose intolerance respectively. Fifty-three (34.0%) participants were classified as combined IS while on the opposite 51 participants (32.7%) were classified as combined IR and 26 (16.7%) participants had either muscle IR or liver IR. For similar body mass index and total fat mass, participants with liver IR were more likely to have lower whole-body IS, dysglycemia and higher visceral fat, liver fat index, triglycerides and alanine aminotransferase than participants with muscle IR. Conclusion In the present study, the presence of liver IR is associated with a higher prevalence of dysglycemia, ectopic fat accumulation and metabolic abnormalities than muscle IR.

      PubDate: 2016-12-12T09:34:29Z
      DOI: 10.1016/j.ando.2016.10.003
       
  • Polycystic ovary syndrome: A new phenotype in mosaic variegated aneuploidy
           syndrome'
    • Authors: Fatma Chaker; Mélika Chihaoui; Meriem Yazidi; Ons Rejeb; Hedia Slimane; Sonia Neji; Houda Kraoua
      Abstract: Publication date: Available online 5 December 2016
      Source:Annales d'Endocrinologie
      Author(s): Fatma Chaker, Mélika Chihaoui, Meriem Yazidi, Ons Rejeb, Hedia Slimane, Sonia Neji, Houda Kraoua


      PubDate: 2016-12-05T17:26:37Z
      DOI: 10.1016/j.ando.2016.08.002
       
  • Fetal hypothyroidism induced by maternal anti-TSH receptor blocking
           antibodies and complicated by polyhydramnios despite the absence of
           goiter. Treatment by intra-amniotic injections of levothyroxine
    • Authors: Adèle Menut-Ruel; Marie Barthod; Anne-Sophie Gauchez; Clémentine Dupuis; Anne Charrie; Claire Dubois; Agnès Leriche; Jean-François Polverelli; Marc Althuser; Pierre Simon Jouk; Olivier Chabre
      Abstract: Publication date: Available online 2 December 2016
      Source:Annales d'Endocrinologie
      Author(s): Adèle Menut-Ruel, Marie Barthod, Anne-Sophie Gauchez, Clémentine Dupuis, Anne Charrie, Claire Dubois, Agnès Leriche, Jean-François Polverelli, Marc Althuser, Pierre Simon Jouk, Olivier Chabre


      PubDate: 2016-12-05T17:26:37Z
      DOI: 10.1016/j.ando.2016.09.002
       
  • Early progression under mitotane and polychemotherapy does not mean
           failure in adrenocortical carcinoma patient
    • Authors: Ségolène Hescot; Sophie Leboulleux; Caroline Caramella; Angelo Paci; Marc Lombes; Amandine Berdelou; Eric Baudin
      Abstract: Publication date: Available online 22 November 2016
      Source:Annales d'Endocrinologie
      Author(s): Ségolène Hescot, Sophie Leboulleux, Caroline Caramella, Angelo Paci, Marc Lombes, Amandine Berdelou, Eric Baudin


      PubDate: 2016-12-05T17:26:37Z
      DOI: 10.1016/j.ando.2016.10.001
       
  • Choroidal metastasis from papillary thyroid cancer: An unusual feature of
           a common disease
    • Authors: Athanasios Fountas; Stelios Tigas; Zoe Giotaki; Agathocles Tsatsoulis; Chris D. Kalogeropoulos
      Abstract: Publication date: Available online 22 November 2016
      Source:Annales d'Endocrinologie
      Author(s): Athanasios Fountas, Stelios Tigas, Zoe Giotaki, Agathocles Tsatsoulis, Chris D. Kalogeropoulos


      PubDate: 2016-12-05T17:26:37Z
      DOI: 10.1016/j.ando.2016.09.001
       
  • An old retrocardiac mass fortuitously reclassified as paraganglioma
    • Authors: Lucien Marchand; Laetitia Garby; Cécile Nozières; Gérald Raverot; Françoise Borson-Chazot
      Abstract: Publication date: Available online 24 October 2016
      Source:Annales d'Endocrinologie
      Author(s): Lucien Marchand, Laetitia Garby, Cécile Nozières, Gérald Raverot, Françoise Borson-Chazot


      PubDate: 2016-10-30T16:57:49Z
      DOI: 10.1016/j.ando.2016.06.002
       
  • Thyroid hormone transport across the placenta
    • Authors: Theo J. Visser
      Abstract: Publication date: Available online 19 September 2016
      Source:Annales d'Endocrinologie
      Author(s): Theo J. Visser


      PubDate: 2016-09-22T04:26:45Z
      DOI: 10.1016/j.ando.2016.07.006
       
  • Current biomarkers of invasive sporadic pituitary adenomas
    • Authors: Xin Zheng; Song Li; Weihua Zhang; Zhenle Zang; Jintao Hu; Hui Yang
      Abstract: Publication date: Available online 19 September 2016
      Source:Annales d'Endocrinologie
      Author(s): Xin Zheng, Song Li, Weihua Zhang, Zhenle Zang, Jintao Hu, Hui Yang
      Though pituitary adenomas (PA) are considered benign, some of them exhibit invasive behaviors such as recurrence and low rate of total surgical resection. Reliable prognostic biomarkers for invasive PA are highly desired; however they remain to be identified. In this review, we summarize the current controversial findings of biomarkers for invasive sporadic PA, and we discuss the possible reasons for the controversies.

      PubDate: 2016-09-22T04:26:45Z
      DOI: 10.1016/j.ando.2016.02.004
       
  • Mucinous carcinoma of the thyroid: A case report and review of the
           literature
    • Authors: Mohamed Yahya Bajja; Fatima Zahra Benassila; Radallah Larbi Abada; Mohamed Mahtar; Asma Chadli
      Abstract: Publication date: Available online 19 September 2016
      Source:Annales d'Endocrinologie
      Author(s): Mohamed Yahya Bajja, Fatima Zahra Benassila, Radallah Larbi Abada, Mohamed Mahtar, Asma Chadli
      We report the case of a primary mucinous carcinoma of the thyroid in a man of 74 who had a 4-cm nodule in the right lobe of the thyroid, with a solido-cystic appearance on ultrasound associated with lymph node metastases. On scintigraphy, the nodule was hot and not extinctive. The patient underwent total thyroidectomy with a ipsilateral right lymph node dissection. The immunohistochemical study showed the negativity of CK 7 and CK 20 and the positivity of thyroglobulin and TTF 1. Postoperatively the rate of blood thyroglobulin 3 months after surgery had collapsed to 0.17ng/ml. The evolution was marked by the appearance of pulmonary metastasis and the patient died 4 months after surgery. Histological study showed the presence of almas of neoplastic cells surrounded by large deposits of extracellular mucin. Primitive mucinous carcinoma of the thyroid is a rare tumor which differential diagnosis is established on the positive immunohistochemistry of thyroglobulin and TTF1 but negative for other markers.

      PubDate: 2016-09-22T04:26:45Z
      DOI: 10.1016/j.ando.2016.02.007
       
  • Impact of maternal steroids during pregnancy
    • Authors: Rebecca M. Reynolds
      Abstract: Publication date: Available online 16 September 2016
      Source:Annales d'Endocrinologie
      Author(s): Rebecca M. Reynolds
      Increased fetal exposure to glucocorticoids is a key mechanism thought to underlie the early life programming of later life disease. There is substantial experimental data in animal models in support of this hypothesis. Emerging evidence suggests glucocorticoid programming may also occur in humans with some studies now linking maternal endogenous cortisol levels with size at birth and gestation at delivery. The dramatic changes to the maternal hypothalamic-pituitary-adrenal axis during pregnancy mean that large-scale studies in humans are challenging to conduct. One of the key regulators of fetal glucocorticoid exposure is the activity of placental “barrier” enzyme 11β-hydroxysteroid dehydrogenase type 2 (HSD2) which converts active cortisol to inactive cortisone. In animal models, this enzyme is down-regulated by various influences including maternal malnutrition, inflammation or stress but it is not known whether this is a major factor in regulation of human fetal glucocorticoid exposure. More studies are needed to understand the mechanisms whereby altered fetal glucocorticoid exposure may alter fetal growth trajectories and whether changes in the maternal hypothalamic-pituitary-adrenal axis in pregnancy could be suitable as a biomarker to identify those pregnancies most at risk.

      PubDate: 2016-09-22T04:26:45Z
      DOI: 10.1016/j.ando.2016.04.027
       
  • Claire Douillard, Pascal Houillier, Juerg Nussberger and Xavier Girerd in
           response to the correspondence by Damien Denimal entitled: “Comments on
           French SFE/SFHTA/AFCE Consensus on Primary aldosteronism, Part 2:
           Diagnosis First steps”. Ann Endocrinol 2016
    • Authors: Claire Douillard; Pascal Houillier; Juerg Nussberger; Xavier Girerd
      Abstract: Publication date: Available online 16 September 2016
      Source:Annales d'Endocrinologie
      Author(s): Claire Douillard, Pascal Houillier, Juerg Nussberger, Xavier Girerd


      PubDate: 2016-09-22T04:26:45Z
      DOI: 10.1016/j.ando.2016.07.003
       
  • Reasons for non-intensification of treatment in people with type 2
           diabetes receiving oral monotherapy: Outcomes from the prospective
           DIAttitude study
    • Authors: Beverley Balkau; Serge Halimi; Jean-Frédéric Blickle; Bruno Vergès; Antoine Avignon; Claude Attali; Isabelle Chartier; Elisabeth Amelineau
      Abstract: Publication date: Available online 16 September 2016
      Source:Annales d'Endocrinologie
      Author(s): Beverley Balkau, Serge Halimi, Jean-Frédéric Blickle, Bruno Vergès, Antoine Avignon, Claude Attali, Isabelle Chartier, Elisabeth Amelineau
      Objectives To describe the management of glucose-lowering agents in people with type 2 diabetes initially on oral monotherapy, cared for by French general practitioners, and to identify reasons underlying treatment non-intensification. Methods People with type 2 diabetes on oral monotherapy were recruited by general practitioners and followed-up over 12 months. Patient characteristics, HbA1c, and glucose-lowering treatments were recorded electronically. Management objectives and reasons for treatment non-intensification were solicited from the general practitioners. Results A total of 1212 patients were enrolled by 198 general practitioners; 937 patients (mean age 68 years) were treated with oral monotherapy, and 916 patients had at least two successive HbA1c values recorded. Of these, 390 patients (43%) had HbA1c≥6.5% on both occasions, and 164/390 (42%) had their treatment intensified. The 226 patients whose treatment was not intensified were older (69±11 years vs. 66±12 years, P =0.02) and had better glycaemic control at study inclusion (6.9%±0.6 vs. 7.3%±0.8, P <0.0001) than treatment intensified patients. Among uncontrolled patients, there were no differences in general practitioner treatment objectives at inclusion for treatment intensified and non-intensified patients; the main reason given by general practitioners for non-intensification was that the patient had an adequate HbA1c (66%). HbA1c did exceed the 6.5% target, but was less than 7.0% in 69% of cases. Conclusions General practitioners showed a patient-centred approach to treatment, but clinical inertia was apparent for 31% of the uncontrolled patients.

      PubDate: 2016-09-22T04:26:45Z
      DOI: 10.1016/j.ando.2016.03.001
       
  • The prediction roles of asymmetric dimethyl-arginine, adiponectin and
           apelin for macroangiopathy in patients with impaired glucose regulation
    • Authors: Shan Huang; Dajin Zou; Wenfang Peng; Xiaohong Jiang; Kan Shao; Lili Xia; Yubin Tang
      Abstract: Publication date: Available online 15 September 2016
      Source:Annales d'Endocrinologie
      Author(s): Shan Huang, Dajin Zou, Wenfang Peng, Xiaohong Jiang, Kan Shao, Lili Xia, Yubin Tang
      Purpose To investigate the effects of asymmetric dimethyl-arginine (ADMA), adiponectin (APN) and apelin in predicting macroangiopathy in impaired glucose regulation (IGR) patients. Methods A total of 210 patients undergoing oral glucose tolerance test were included in this study. They were classified to normal glucose tolerance (NGT, n =42), impaired fasting glucose (IFG, n =36), impaired glucose tolerance (IGT, n =92, including 44 IGT1 and 48 IGT2 patients) and IFG+IGT (n =40) groups. APN, apelin and ADMA levels, blood pressure, blood lipid, insulin, body mass index (BMI), and homeostasis model assessment of insulin resistance (HOMA-IR) were detected. The severity and extent of coronary atherosclerosis were determined by the Gensini score. Results The prevalence of coronary heart disease and Gensini scores in IGT and IFG+IGT groups were similar but both were higher than NGT and IFG groups (all P <0.05). Lower APN, higher ADMA and apelin levels were witnessed in IGT and IGT+IFG groups compared with NGT and IFG groups (all P <0.05). IGT2 group had higher 2-h PG and apelin levels and Gensini scores but lower APN levels than IGT1 group (all P <0.05). Gensini score was positively correlated with apelin (r =0.669) and ADMA (r =0.764), but were negatively correlated with APN (r =–0.555, all P <0.001). ADMA and APN were the independent factors affecting Gensini score. Conclusion ADMA and APN levels could be predictive factors for macroangiopathy in IGR patients, especially in IGT cases.

      PubDate: 2016-09-16T12:19:03Z
      DOI: 10.1016/j.ando.2016.03.004
       
  • Long-term outcome of macroprolactinomas
    • Authors: Lori Képénékian; Hélène Cebula; Frédéric Castinetti; Thomas Graillon; Thierry Brue; Bernard Goichot
      Abstract: Publication date: Available online 15 September 2016
      Source:Annales d'Endocrinologie
      Author(s): Lori Képénékian, Hélène Cebula, Frédéric Castinetti, Thomas Graillon, Thierry Brue, Bernard Goichot
      Objective Management of macroprolactinomas has dramatically changed in recent decades, from surgical to medical treatment as first-line therapy, with the development of dopamine agonists (DA). But few data exist on the long-term outcome of these patients. Patients and methods Retrospective descriptive multicenter study of patients with macroprolactinoma followed for at least 5 years between 1973 and 2008 at the University Hospitals of Strasbourg and Marseille. Results Forty-eight patients were included with 27 men, hypopituitarism in 33.3% of all patients and mean serum prolactin (PRL) level at diagnosis 2218.2±4154.7μg/L. Among the patients, 58.3% received medical treatment, 25% had additional surgery and 12.5% surgery and radiotherapy. The mean follow-up duration was 196±100 months. At the end of follow-up, 10 patients (20.8%) were cured (i.e. normal PRL level and normal imaging, no symptoms and withdrawal of DA≥1 year), 33 (68.8%) were controlled (i.e. normal PRL level, normal or abnormal imaging, no symptoms, DA in progress) and 5 (10.4%) were uncontrolled. Uncontrolled patients had significant higher baseline PRL level (P = 0.0412) and cabergoline cumulative dose (P = 0.0065) compared to the controlled group. There was no increase in frequency of hypopituitarism. Clinically significant valvular heart disease was found in 2 patients but screening was not systematic. Conclusions Macroprolactinoma is currently most often a chronic disease controlled with DA. However, uncertainty about the adverse effects associated with high cumulative doses and the lack of data on the prognosis at very long-term should incite to revisit current strategies, including the role of surgery combined to medical treatment.

      PubDate: 2016-09-16T12:19:03Z
      DOI: 10.1016/j.ando.2016.07.004
       
  • Overdiagnosis of thyroid cancer in the Marne and Ardennes Departments of
           France from 1975 to 2014
    • Authors: Caroline Saint-Martin; Moustapha Dramé; Sandrine Dabakuyo; Lukshe Kanagaratnam; Patrick Arveux; Claire Schvartz
      Abstract: Publication date: Available online 15 September 2016
      Source:Annales d'Endocrinologie
      Author(s): Caroline Saint-Martin, Moustapha Dramé, Sandrine Dabakuyo, Lukshe Kanagaratnam, Patrick Arveux, Claire Schvartz
      Objectives Incidence of thyroid cancer has increased considerably in France in recent years, but the mortality rate has declined only slightly. Part of this increased incidence could be attributable to overdiagnosis. We aimed to estimate the contribution of overdiagnosis to the incidence of papillary thyroid cancer. Material and methods Incidence rates were calculated based on data from the specialised Marnes-Ardennes thyroid cancer registry, for cancers diagnosed between 1975 and 2014, by age category and by five-year period. The population was divided into two groups according to pTNM classification at diagnosis (i.e. localised or invasive). Overdiagnosis was defined as the difference in incidence rates between the invasive cancer and localised cancer groups. This rate was then divided by the incidence rate in the localised cancer group for the most recent period (2010–2014) to obtain the proportion of cancers attributable to overdiagnosis. Results In total, 2008 patients were included. The proportion of incidence attributable to overdiagnosis for the period 2010–2014 was estimated at 7 and 62% in men and women aged < 50 years respectively, and at 65 and 73% respectively in men and women aged ≥ 50 years. Conclusion We observed a high proportion of cancers attributable to overdiagnosis. This finding raises the issue of patient management, with the risk of overtreatment, and the repercussions on quality of life for patients diagnosed with cancer.

      PubDate: 2016-09-16T12:19:03Z
      DOI: 10.1016/j.ando.2016.07.005
       
  • Association between DNA methylation of SORL1 5′-flanking region and mild
           cognitive impairment in type 2 diabetes mellitus
    • Authors: Yang Yu; Wang Mingjiao; Xiaohui Yang; Miao Sui; Tao Zhang; Jin Liang; Xinyi Gu; Xiaomei Wang
      Abstract: Publication date: Available online 15 September 2016
      Source:Annales d'Endocrinologie
      Author(s): Yang Yu, Wang Mingjiao, Xiaohui Yang, Miao Sui, Tao Zhang, Jin Liang, Xinyi Gu, Xiaomei Wang
      Objectives In the present study, we examined whether DNA methylation of the sortilin-related receptor 1 (SORL1) 5′-flanking region is associated with the manifestation and clinical presentation of mild cognitive impairment in type 2 diabetes mellitus (T2DM). Methods Of 84 diabetic patients with mild cognitive impairment (MCI group), 78 diabetic patients without mild cognitive impairment (NMCI group) and 80 age-matched normal controls (NC group), the DNA methylation of the SORL1 5′-flanking region was completely analyzed. The SORL1 methylation ratios of the above three groups were compared statistically. Next, we investigated the correlation between the DNA methylation status and the clinical presentation of diabetes with or without cognitive impairment (MCI and NMCI groups). Results The methylation ratio (86.9%) of MCI patients was significantly higher than that in the NMCI patients (35.9%, P <0.05) and in the NC group (11.3%, P <0.05). Moreover, the diabetic patients with methylation alleles had greater ages, longer diabetes duration, lower MOCA scores and higher plasma amyloid Aβ 1-42 levels than those with unmethylation alleles (P <0.05). Conclusion These results suggested that the DNA methylation of the SORL1 5′-flanking region may significantly influence the manifestation of mild cognitive impairment in T2DM, and might be associated with its neurocognitive presentation.

      PubDate: 2016-09-16T12:19:03Z
      DOI: 10.1016/j.ando.2016.02.008
       
  • Change in women's eating habits during the menstrual cycle
    • Authors: Ines Kammoun; Wafa Ben Saâda; Amira Sifaou; Emna Haouat; Hajer Kandara; Leila Ben Salem; Claude Ben Slama
      Abstract: Publication date: Available online 12 September 2016
      Source:Annales d'Endocrinologie
      Author(s): Ines Kammoun, Wafa Ben Saâda, Amira Sifaou, Emna Haouat, Hajer Kandara, Leila Ben Salem, Claude Ben Slama
      Objectives During the menstrual cycle, the influence of hormonal variations on dietary habits in women has been suggested by several studies. In this context, our work aimed to assess the spontaneous food intake and the anthropometric parameters of women at different periods of their menstrual cycles. Methods This prospective study included 30 healthy women with regular periods (28 to 30 days), aged between 18 and 45. We assessed the spontaneous food intake and the anthropometric measurements (weight and waist circumference) of the participants, during the follicular, peri-ovulatory and luteal phases of their menstrual cycles. Results Our results showed a slight but significant increase in body weight during the luteal phase (P =0.022) and the follicular phase (P =0.017) compared with the peri-ovulatory phase, without any significant change in waist circumference. The caloric intake increased during the peri-ovulatory (P <0.001) and the luteal phases (P <0.001), compared with the follicular phase, with a significant increase in carbohydrate (P <0.001), lipid (P =0.008) and protein (P =0.008) intake. Conclusions Our study showed a significant decrease in women's weight during the peri-ovulatory phase, with a significant increase in caloric intake during the luteal phase of the menstrual cycle. Divergent results have been reported by other authors and the physiopathology of these changes is still poorly understood.

      PubDate: 2016-09-16T12:19:03Z
      DOI: 10.1016/j.ando.2016.07.001
       
  • Comments on “French SFE/SFHTA/AFCE consensus on primary aldosteronism,
           part 2: First diagnostic steps”
    • Authors: Damien Denimal
      Abstract: Publication date: Available online 9 September 2016
      Source:Annales d'Endocrinologie
      Author(s): Damien Denimal


      PubDate: 2016-09-11T05:04:18Z
      DOI: 10.1016/j.ando.2016.07.002
       
  • Embolization of thyroid arteries in a patient with compressive
           intrathoracic goiter ineligible to surgery or radioiodine therapy
    • Authors: Roxane Ducloux; Marc Sapoval; Gilles Russ
      Abstract: Publication date: Available online 9 September 2016
      Source:Annales d'Endocrinologie
      Author(s): Roxane Ducloux, Marc Sapoval, Gilles Russ


      PubDate: 2016-09-11T05:04:18Z
      DOI: 10.1016/j.ando.2016.06.003
       
  • Revue des travaux menés par le programme cartes d’identité des tumeurs
           sur les tumeurs endocrines : impacts sur la pathologie et la prise en
           charge des patients
    • Abstract: Publication date: September 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 4
      Author(s): A. De Reyniès
      La pratique médicale évolue rapidement en cancérologie sous l’effet des apports de la génomique. Les tumeurs endocrines n’y font pas exception et le programme cartes d’identité des tumeurs (CIT) en lien avec le réseau COMETE a notablement contribué à faire évoluer la pathologie des tumeurs de la surrénale [1–5]. Le programme CIT est également engagé dans des travaux (non publiés) sur les tumeurs endocrines du poumon, avec le développement d’une méthode révolutionnaire de pathologie in silico, permettant de décrire au moins en partie l’hétérogénéité intratumorale chez un patient, à partir du transcriptome de sa tumeur. Il est intéressant de voir en quoi ces différents apports du programme CIT sont susceptibles de modifier la prise en charge des patients atteints de tumeurs endocrines.

      PubDate: 2016-09-07T20:10:57Z
       
  • Les analyses métabolomiques et leur apport en endocrinologie
    • Authors: Junot
      Abstract: Publication date: September 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 4
      Author(s): C. Junot
      À l’échelle d’un système vivant, le métabolisme est organisé en réseaux complexes de réactions biochimiques que les études de biologie intégrative tentent de cerner dans leur globalité. Alors que les méthodes classiques de chimie analytique ne permettent que le dosage ciblé de métabolites préalablement sélectionnés, l’essor de la bioinformatique et les développements technologiques réalisés en instrumentation analytique durant ces deux dernières décennies ont fait évoluer ces analyses traditionnelles en des approches globales et sans a priori dites métabolomiques, qui peuvent assurer la détection mais aussi la quantification simultanée de plusieurs dizaines à plusieurs centaines de biomolécules. Les analyses métabolomiques permettent ainsi de mettre en évidence des interrelations métaboliques qui n’auraient pu être décelées sur la base d’un raisonnement biochimique. Grâce à la possibilité qu’elles offrent de détecter non seulement les métabolites impliqués dans le fonctionnement cellulaire, mais également des xénobiotiques (médicaments, polluants, composés d’origine alimentaire) et les produits issus de leur métabolisation par l’organisme (au niveau hépatique ou par la flore intestinale), elles permettent de caractériser des biomarqueurs témoignant d’interactions entre individus et environnement dans le cadre d’analyses de cohortes médicales. Au cours de cette intervention, je présenterai les analyses métabolomiques (déroulement et technologies associées) et des applications réalisées dans le domaine de l’endocrinologie.

      PubDate: 2016-09-07T20:10:57Z
       
  • Gènes de la puberté précoce
    • Authors: Kaiser
      Abstract: Publication date: September 2016
      Source:Annales d'Endocrinologie, Volume 77, Issue 4
      Author(s): U. Kaiser
      The hypothalamic-pituitary-gonadal (HPG) axis controls puberty and reproduction and is tightly regulated by a complex network of excitatory and inhibitory factors. Delayed or absent activation of the HPG axis results in delayed puberty or hypogonadotropic hypogonadism, whereas early activation results in central precocious puberty (CPP). In recent years, many genes have been identified in this complex network, providing insight into the regulation of GnRH secretion. These advances were heralded by the discovery of the kisspeptin system as a critical component for the activation of GnRH secretion, and followed by the discovery of the tachykinin, neurokinin B and its role in pubertal activation in turn, through regulation of kisspeptin secretion. More recently, we identified loss-of-function mutations in the MKRN3 gene, encoding makorin ring finger protein 3, as an important cause of CPP. MKRN3 is an imprinted gene on chromosome 15q11.2 in the Prader-Willi Syndrome critical region, with expression only from the paternally inherited allele. MKRN3 is expressed at high levels in the mouse hypothalamus prepubertally and decreases prior to puberty onset, suggesting that it acts as a “brake” on GnRH secretion. To date, MKRN3 is the first factor to be identified that likely has an inhibitory role on puberty in humans. The discovery of this new genetic link to early puberty will help to diagnose the cause of precocious puberty or to identify children at risk for developing precocious puberty, and the elucidation of the mechanisms by which MKRN3 regulates GnRH secretion, will bring new insights into reproductive physiology.

      PubDate: 2016-09-07T20:10:57Z
       
  • Conseil scientifique du 33e Congrès de la SFE, Bordeaux 2016
    • Abstract: Publication date: Available online 23 August 2016
      Source:Annales d'Endocrinologie


      PubDate: 2016-08-24T11:17:46Z
       
 
 
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