Publisher: Elsevier   (Total: 3161 journals)

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Showing 1 - 200 of 3161 Journals sorted alphabetically
Academic Pediatrics     Hybrid Journal   (Followers: 39, SJR: 1.655, CiteScore: 2)
Academic Radiology     Hybrid Journal   (Followers: 26, SJR: 1.015, CiteScore: 2)
Accident Analysis & Prevention     Partially Free   (Followers: 106, SJR: 1.462, CiteScore: 3)
Accounting Forum     Hybrid Journal   (Followers: 28, SJR: 0.932, CiteScore: 2)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 44, SJR: 1.771, CiteScore: 3)
Achievements in the Life Sciences     Open Access   (Followers: 7)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 6)
Acta Astronautica     Hybrid Journal   (Followers: 448, SJR: 0.758, CiteScore: 2)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 2)
Acta Biomaterialia     Hybrid Journal   (Followers: 30, SJR: 1.967, CiteScore: 7)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 3)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 11, SJR: 0.18, CiteScore: 1)
Acta Histochemica     Hybrid Journal   (Followers: 5, SJR: 0.661, CiteScore: 2)
Acta Materialia     Hybrid Journal   (Followers: 326, SJR: 3.263, CiteScore: 6)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.504, CiteScore: 1)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.542, CiteScore: 1)
Acta Oecologica     Hybrid Journal   (Followers: 12, SJR: 0.834, CiteScore: 2)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription  
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 2, SJR: 0.307, CiteScore: 0)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 2, SJR: 1.793, CiteScore: 6)
Acta Psychologica     Hybrid Journal   (Followers: 26, SJR: 1.331, CiteScore: 2)
Acta Sociológica     Open Access   (Followers: 1)
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.052, CiteScore: 2)
Acta Urológica Portuguesa     Open Access   (Followers: 1)
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 3, SJR: 0.374, CiteScore: 1)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 2)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 3, SJR: 0.344, CiteScore: 1)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 1)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 7, SJR: 0.19, CiteScore: 0)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 3)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 8)
Acute Pain     Full-text available via subscription   (Followers: 15, SJR: 2.671, CiteScore: 5)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.53, CiteScore: 4)
Addictive Behaviors     Hybrid Journal   (Followers: 18, SJR: 1.29, CiteScore: 3)
Addictive Behaviors Reports     Open Access   (Followers: 9, SJR: 0.755, CiteScore: 2)
Additive Manufacturing     Hybrid Journal   (Followers: 13, SJR: 2.611, CiteScore: 8)
Additives for Polymers     Full-text available via subscription   (Followers: 22)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 190, SJR: 4.09, CiteScore: 13)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 13, SJR: 1.167, CiteScore: 4)
Advanced Powder Technology     Hybrid Journal   (Followers: 17, SJR: 0.694, CiteScore: 3)
Advances in Accounting     Hybrid Journal   (Followers: 9, SJR: 0.277, CiteScore: 1)
Advances in Agronomy     Full-text available via subscription   (Followers: 17, SJR: 2.384, CiteScore: 5)
Advances in Anesthesia     Full-text available via subscription   (Followers: 30, SJR: 0.126, CiteScore: 0)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 2)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 12, SJR: 0.992, CiteScore: 1)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 12, SJR: 1.551, CiteScore: 4)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 24, SJR: 2.089, CiteScore: 5)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 15, SJR: 0.572, CiteScore: 2)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.61, CiteScore: 7)
Advances in Botanical Research     Full-text available via subscription   (Followers: 1, SJR: 0.686, CiteScore: 2)
Advances in Cancer Research     Full-text available via subscription   (Followers: 35, SJR: 3.043, CiteScore: 6)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 1.453, CiteScore: 2)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 1.992, CiteScore: 5)
Advances in Cell Aging and Gerontology     Full-text available via subscription   (Followers: 5)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 14)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 29, SJR: 0.156, CiteScore: 1)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 11, SJR: 0.713, CiteScore: 1)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 11, SJR: 1.316, CiteScore: 2)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 26, SJR: 1.562, CiteScore: 3)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 21, SJR: 1.977, CiteScore: 8)
Advances in Computers     Full-text available via subscription   (Followers: 14, SJR: 0.205, CiteScore: 1)
Advances in Dermatology     Full-text available via subscription   (Followers: 16)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 14)
Advances in Digestive Medicine     Open Access   (Followers: 13)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 7)
Advances in Drug Research     Full-text available via subscription   (Followers: 26)
Advances in Ecological Research     Full-text available via subscription   (Followers: 45, SJR: 2.524, CiteScore: 4)
Advances in Engineering Software     Hybrid Journal   (Followers: 30, SJR: 1.159, CiteScore: 4)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 9)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 52, SJR: 5.39, CiteScore: 8)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 2)
Advances in Fluorine Science     Full-text available via subscription   (Followers: 9)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 68, SJR: 0.591, CiteScore: 2)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 17)
Advances in Genetics     Full-text available via subscription   (Followers: 21, SJR: 1.354, CiteScore: 4)
Advances in Genome Biology     Full-text available via subscription   (Followers: 12, SJR: 12.74, CiteScore: 13)
Advances in Geophysics     Full-text available via subscription   (Followers: 8, SJR: 1.193, CiteScore: 3)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 26, SJR: 0.368, CiteScore: 1)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 11, SJR: 0.749, CiteScore: 3)
Advances in Human Factors/Ergonomics     Full-text available via subscription   (Followers: 26)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 3, SJR: 0.193, CiteScore: 0)
Advances in Immunology     Full-text available via subscription   (Followers: 37, SJR: 4.433, CiteScore: 6)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 10, SJR: 1.163, CiteScore: 2)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 2, SJR: 1.938, CiteScore: 3)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6, SJR: 0.176, CiteScore: 0)
Advances in Intl. Accounting     Full-text available via subscription   (Followers: 3)
Advances in Life Course Research     Hybrid Journal   (Followers: 9, SJR: 0.682, CiteScore: 2)
Advances in Lipobiology     Full-text available via subscription   (Followers: 1)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 8)
Advances in Marine Biology     Full-text available via subscription   (Followers: 21, SJR: 0.88, CiteScore: 2)
Advances in Mathematics     Full-text available via subscription   (Followers: 17, SJR: 3.027, CiteScore: 2)
Advances in Medical Sciences     Hybrid Journal   (Followers: 9, SJR: 0.694, CiteScore: 2)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 5, SJR: 1.158, CiteScore: 3)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 26)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 8)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.182, CiteScore: 0)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 5)
Advances in Oncobiology     Full-text available via subscription   (Followers: 2)
Advances in Organ Biology     Full-text available via subscription   (Followers: 2)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 18, SJR: 1.875, CiteScore: 4)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.174, CiteScore: 0)
Advances in Parasitology     Full-text available via subscription   (Followers: 6, SJR: 1.579, CiteScore: 4)
Advances in Pediatrics     Full-text available via subscription   (Followers: 27, SJR: 0.461, CiteScore: 1)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 19)
Advances in Pharmacology     Full-text available via subscription   (Followers: 17, SJR: 1.536, CiteScore: 3)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 10, SJR: 0.574, CiteScore: 1)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.109, CiteScore: 1)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 11)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 6)
Advances in Porous Media     Full-text available via subscription   (Followers: 5)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 19)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 20, SJR: 0.791, CiteScore: 2)
Advances in Psychology     Full-text available via subscription   (Followers: 69)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 7, SJR: 0.371, CiteScore: 1)
Advances in Radiation Oncology     Open Access   (Followers: 3, SJR: 0.263, CiteScore: 1)
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 3, SJR: 0.101, CiteScore: 0)
Advances in Space Biology and Medicine     Full-text available via subscription   (Followers: 7)
Advances in Space Research     Full-text available via subscription   (Followers: 431, SJR: 0.569, CiteScore: 2)
Advances in Structural Biology     Full-text available via subscription   (Followers: 6)
Advances in Surgery     Full-text available via subscription   (Followers: 13, SJR: 0.555, CiteScore: 2)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 37, SJR: 2.208, CiteScore: 4)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 20)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 15)
Advances in Virus Research     Full-text available via subscription   (Followers: 6, SJR: 2.262, CiteScore: 5)
Advances in Water Resources     Hybrid Journal   (Followers: 57, SJR: 1.551, CiteScore: 3)
Aeolian Research     Hybrid Journal   (Followers: 6, SJR: 1.117, CiteScore: 3)
Aerospace Science and Technology     Hybrid Journal   (Followers: 398, SJR: 0.796, CiteScore: 3)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.42, CiteScore: 2)
African J. of Emergency Medicine     Open Access   (Followers: 6, SJR: 0.296, CiteScore: 0)
Ageing Research Reviews     Hybrid Journal   (Followers: 12, SJR: 3.671, CiteScore: 9)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 489, SJR: 1.238, CiteScore: 3)
Agri Gene     Hybrid Journal   (Followers: 1, SJR: 0.13, CiteScore: 0)
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 18, SJR: 1.818, CiteScore: 5)
Agricultural Systems     Hybrid Journal   (Followers: 32, SJR: 1.156, CiteScore: 4)
Agricultural Water Management     Hybrid Journal   (Followers: 47, SJR: 1.272, CiteScore: 3)
Agriculture and Agricultural Science Procedia     Open Access   (Followers: 4)
Agriculture and Natural Resources     Open Access   (Followers: 3)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 58, SJR: 1.747, CiteScore: 4)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.589, CiteScore: 3)
Air Medical J.     Hybrid Journal   (Followers: 8, SJR: 0.26, CiteScore: 0)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.19, CiteScore: 0)
Alcohol     Hybrid Journal   (Followers: 12, SJR: 1.153, CiteScore: 3)
Alcoholism and Drug Addiction     Open Access   (Followers: 12)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 2, SJR: 0.604, CiteScore: 3)
Alexandria J. of Medicine     Open Access   (Followers: 1, SJR: 0.191, CiteScore: 1)
Algal Research     Partially Free   (Followers: 11, SJR: 1.142, CiteScore: 4)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 2)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.504, CiteScore: 1)
Allergology Intl.     Open Access   (Followers: 5, SJR: 1.148, CiteScore: 2)
Alpha Omegan     Full-text available via subscription   (SJR: 3.521, CiteScore: 6)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 11, SJR: 0.201, CiteScore: 1)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 55, SJR: 4.66, CiteScore: 10)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 6, SJR: 1.796, CiteScore: 4)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 6, SJR: 1.108, CiteScore: 3)
Ambulatory Pediatrics     Hybrid Journal   (Followers: 5)
American Heart J.     Hybrid Journal   (Followers: 58, SJR: 3.267, CiteScore: 4)
American J. of Cardiology     Hybrid Journal   (Followers: 67, SJR: 1.93, CiteScore: 3)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 48, SJR: 0.604, CiteScore: 1)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 13)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 15, SJR: 1.524, CiteScore: 3)
American J. of Human Genetics     Hybrid Journal   (Followers: 39, SJR: 7.45, CiteScore: 8)
American J. of Infection Control     Hybrid Journal   (Followers: 29, SJR: 1.062, CiteScore: 2)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 37, SJR: 2.973, CiteScore: 4)
American J. of Medicine     Hybrid Journal   (Followers: 50)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3, SJR: 1.967, CiteScore: 2)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 266, SJR: 2.7, CiteScore: 4)
American J. of Ophthalmology     Hybrid Journal   (Followers: 67, SJR: 3.184, CiteScore: 4)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 5, SJR: 0.265, CiteScore: 0)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.289, CiteScore: 1)
American J. of Otolaryngology     Hybrid Journal   (Followers: 25, SJR: 0.59, CiteScore: 1)
American J. of Pathology     Hybrid Journal   (Followers: 32, SJR: 2.139, CiteScore: 4)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 30, SJR: 2.164, CiteScore: 4)
American J. of Surgery     Hybrid Journal   (Followers: 39, SJR: 1.141, CiteScore: 2)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.767, CiteScore: 1)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 7)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.144, CiteScore: 3)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 67, SJR: 0.138, CiteScore: 0)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 25, SJR: 0.411, CiteScore: 1)
Anales de Cirugia Vascular     Full-text available via subscription   (Followers: 1)
Anales de Pediatría     Full-text available via subscription   (Followers: 3, SJR: 0.277, CiteScore: 0)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription  
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 6, SJR: 4.849, CiteScore: 10)
Analytica Chimica Acta     Hybrid Journal   (Followers: 44, SJR: 1.512, CiteScore: 5)
Analytica Chimica Acta : X     Open Access  
Analytical Biochemistry     Hybrid Journal   (Followers: 216, SJR: 0.633, CiteScore: 2)
Analytical Chemistry Research     Open Access   (Followers: 13, SJR: 0.411, CiteScore: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 14)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 2)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 25, SJR: 0.683, CiteScore: 2)
Angiología     Full-text available via subscription   (SJR: 0.121, CiteScore: 0)
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1, SJR: 0.111, CiteScore: 0)
Animal Behaviour     Hybrid Journal   (Followers: 240, SJR: 1.58, CiteScore: 3)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 7, SJR: 0.937, CiteScore: 2)
Animal Reproduction Science     Hybrid Journal   (Followers: 7, SJR: 0.704, CiteScore: 2)
Annales d'Endocrinologie     Full-text available via subscription   (Followers: 3, SJR: 0.451, CiteScore: 1)

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Similar Journals
Journal Cover
American Journal of the Medical Sciences
Journal Prestige (SJR): 0.767
Citation Impact (citeScore): 1
Number of Followers: 12  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0002-9629
Published by Elsevier Homepage  [3161 journals]
  • Osseous sarcoid mimicking metastatic cancer
    • Abstract: Publication date: Available online 16 January 2020Source: The American Journal of the Medical SciencesAuthor(s): Gurinder Sidhu, Yamen Homsi
       
  • Pulmonary artery pseudoaneurysm caused by lung abscess
    • Abstract: Publication date: Available online 16 January 2020Source: The American Journal of the Medical SciencesAuthor(s): Susumu Saito, Tsukasa Kadota, Mina Gochi
       
  • Acute onset hyperammonemic encephalopathy related to fibrolamellar
           carcinoma: another one bites the dust
    • Abstract: Publication date: Available online 13 January 2020Source: The American Journal of the Medical SciencesAuthor(s): Rodrigo C.T. Surjan, Sergio P. Silveira, João Lucas S. Pinheiro, Pedro Henrique S. Pinheiro, Mauricio F.A. Barros, Silvia Regina P. Soares
       
  • E-cigarettes and vaping associated lung injury: a case series and brief
           review
    • Abstract: Publication date: Available online 13 January 2020Source: The American Journal of the Medical SciencesAuthor(s): Robert Hilton, Ross Summer, Jesse Roman, Baskaran Sundaram, Gautam George
       
  • An unusual cause of gastrointestinal bleeding-mycotic aneurysm with
           aortoduodenal fistula
    • Abstract: Publication date: Available online 13 January 2020Source: The American Journal of the Medical SciencesAuthor(s): Chien-Hung Liu, Chun-Kai Fu
       
  • Demethylation of H3K4me2 is inhibited by GCN5-induced acetylation of LSD1
    • Abstract: Publication date: Available online 7 January 2020Source: The American Journal of the Medical SciencesAuthor(s): Mingwen Jiao, Lijian Xia, Jingbo Chen, Zhonghui CuiAbstractBackgroundHistone demethylase lysine-specific demethylase 1 (LSD1) potentiates cancer process through inducing demethylation of di-methylation of lysine 4 on histone 3 (H3K4me2). Here, we aimed to investigate whether general control non-depressible 5 (GCN5) has an activity to induce acetylation of LSD1, and the function of acetylated LSD1 was further explored.MethodsImmunoblotting was applied to detect GCN5 and LSD1 in colorectal adenocarcinoma cells (SW48 and SNU-C1). GCN5 or LSD1 expression was altered in the cells by transfection. Co-immunoprecipitation and glutathione S-transferase pulldown assays were carried out to examine the association between LSD1 and GCN5. Activity of GCN5 to acetylate LSD1 was determined in vitro. The association between LSD1 and histone was examined, as well as alteration in demethylation of histone, through immunoblotting assay. The complex function of GCN5 and LSD1 was explored by assessing the cellular growth and tumor volume in mice.ResultsLSD1 was acetylated in SW48 and SNU-C1 cells, which was accompanied by the high expression of GCN5. GCN5 induced the acetylation of LSD1 at lysine 433 site. LSD1 has an activity to induce the demethylation of histone, which was not affected by GCN5-induced acetylation. However, GCN5-induced acetylation of LSD1 affected the activity of LSD1 to associate with nucleosome. GCN5 promoted the cellular growth and increased the tumor volume of colon cancer, whereas GCN5-induced acetylation of LSD1 maintained the methylation of histone and repressed cancer process.ConclusionGCN5-induced acetylation of LSD1 impeded progression of colon cancer by inhibiting the demethylation of histone.
       
  • An unexpected case of lagochilascariasis: interdisciplinary management and
           use of 12S and 18S rDNA analysis
    • Abstract: Publication date: Available online 7 January 2020Source: The American Journal of the Medical SciencesAuthor(s): Fernando Martinez-Hernandez, Hector Manuel Prado-Calleros, Juan Pablo Ramirez-Hinojosa, Vladimir Figueroa-Angel, Maria Teresa Lopez-Reynoso, Maria del Carmen Jimenez-Andrade, Isaias Estrada-Moscoso, Nancy Rivas, Javier Escobedo-Ortegon, Ana Flisser, Mirza Romero-Valdovinos, Pablo MaravillaAbstractA Mexican 24-year-old male patient was referred to our hospital due to increased left retroauricular volume with skin fistulisation, resembling an infection by the uncommon worm Lagochilascaris minor. The patient was submitted to lateral skull base surgery. No adult worms or eggs were observed during light and scanning electron microscopy analysis, as well as by histopathologic examination of the small piece of removed tissue, only L3 stage larvae of Lagochilascaris spp. were identified. Polymerase chain reaction (PCR)-sequencing assays were performed using primers for the mitochondrial 12S and the nuclear 18S rDNA gene. DNA of some L. minor adults, previously identified, were used as control. The molecular analysis identified the worm as L. minor. According to previous reports, lagochilascariasis is a complicated infection that requires an interdisciplinary management by different clinical specialists. This is the first time that 12S and 18S rDNA genes are reported as molecular markers for diagnosis of L. minor.
       
  • SAPHO Syndrome
    • Abstract: Publication date: January 2020Source: The American Journal of the Medical Sciences, Volume 359, Issue 1Author(s): Takanobu Hirosawa, Shinichi Katsukura, Taro Shimizu
       
  • Pseudo-Wellens’ Syndrome Temporally Associated With Immune Check
           Point Inhibitors Use
    • Abstract: Publication date: January 2020Source: The American Journal of the Medical Sciences, Volume 359, Issue 1Author(s): Mohamad Muhailan, Ghassan Al-Shbool
       
  • Relation of Decreased Circulating Sortilin Levels With Unfavorable
           Metabolic Profiles in Subjects With Newly Diagnosed Type 2 Diabetes
           Mellitus
    • Abstract: Publication date: January 2020Source: The American Journal of the Medical Sciences, Volume 359, Issue 1Author(s): İsmail Demir, Ozden Yildirim Akan, Aslı Guler, Giray Bozkaya, Behnaz Aslanipour, Mehmet CalanAbstractBackgroundSortilin, a pluripotent peptide hormone, plays a role in glucose and lipid metabolism. A link between sortilin and insulin sensitivity has been implicated. However, the clinical implications of this link remain elusive. Our aims were to investigate whether sortilin levels were altered in subjects with newly diagnosed type 2 diabetes mellitus (nT2DM) compared with subjects with normal glucose tolerance (NGT) and to determine whether a link exist between sortilin levels and metabolic parameters.Materials and MethodsA total of 150 subjects including 75 nT2DM patients and 75 subjects with NGT who were matched in age, body mass index, and sex were enrolled into this case-control study. The circulating levels of sortilin were measured using enzyme-linked immunosorbent assay. A 2-hour 75-g oral glucose tolerance test was used for diagnosis of T2DM. Metabolic parameters of enrolled subjects were also determined.ResultsThe circulating levels of sortilin were found to be significantly lower in subjects with nT2DM than in controls (138.44 ± 38.39 vs. 184.93 ± 49.67 pg/mL, P < 0.001). Sortilin levels showed a negative correlation with insulin resistance and unfavorable lipid profiles, while they were positively correlated with high-density lipoprotein cholesterol in subjects with nT2DM. Linear regression analysis showed an independent and inverse link between sortilin and insulin resistance and unfavorable lipid profiles. Moreover, logistic regression analysis revealed that the subjects with the lowest sortilin levels had an increased risk of nT2DM compared with those subjects with the highest sortilin levels.ConclusionsDecreased circulating levels of sortilin were associated with unfavorable metabolic profiles in subjects with nT2DM.
       
  • An Exceptional Case of Bilateral Atrophic Squirrhus of Breast
    • Abstract: Publication date: January 2020Source: The American Journal of the Medical Sciences, Volume 359, Issue 1Author(s): Wala Ben Kridis, Afef Khanfir
       
  • Rheumatoid Arthritis-Associated Interstitial Lung Disease
    • Abstract: Publication date: Available online 26 December 2019Source: The American Journal of the Medical SciencesAuthor(s): Marina Kristy Ibraheim, Rukma Reddy Govindu
       
  • Exercise capacity and ventilatory efficiency in patients with pulmonary
           embolism after short duration of anticoagulation therapy
    • Abstract: Publication date: Available online 26 December 2019Source: The American Journal of the Medical SciencesAuthor(s): Dandan Huang, Jian Guo, Wenlan Yang, Jinming LiuAbstractBackgroundAlthough anticoagulation therapy can reduce the risk for pulmonary embolism (PE) recurrence, symptoms such as exertional dyspnea or pain can persist for several months to years. Therefore, we aimed to assess the improvement of ventilatory efficiency and exercise capacity during cardiopulmonary exercise test (CPET) in PE patients after short duration of anticoagulant therapy.MethodsPulmonary function testing (PFT), Arterial blood gas analysis (ABG) and CPET were performed in 30 PE patients after anticoagulant therapy of 4 weeks (early phase) and after 6 months (late phase). In addition, another thirty healthy volunteers underwent the same tests.ResultsPercentage of forced vital capacity (FVC %pred) improvement was evident in the PE group (P
       
  • Arterial Complications Associated with Renal Cell Carcinoma
    • Abstract: Publication date: Available online 24 December 2019Source: The American Journal of the Medical SciencesAuthor(s): Jack Hua, David Pointer, Jonathan Silberstein, Albert D. Sam
       
  • Posterior mediastinal mature cystic teratoma-Known but Rare Entity
    • Abstract: Publication date: Available online 14 December 2019Source: The American Journal of the Medical SciencesAuthor(s): Qianqian Feng, Yan Xiao, Fugang Han
       
  • Collagenous Sprue
    • Abstract: Publication date: Available online 14 December 2019Source: The American Journal of the Medical SciencesAuthor(s): Jared Rejeski, Jason Conway, Yi Zhou
       
  • Brachiocephalic Vein Thrombosis
    • Abstract: Publication date: Available online 10 December 2019Source: The American Journal of the Medical SciencesAuthor(s): Takanobu Hirosawa, Taro Shimizu
       
  • Different statin effects of ST-elevation versus non-ST-elevation acute
           myocardial infarction in Korean after stent implantation
    • Abstract: Publication date: Available online 7 December 2019Source: The American Journal of the Medical SciencesAuthor(s): Yong Hoon Kim, Ae-Young Her, Myung Ho Jeong, Byeong-Keuk Kim, Sung-Jin Hong, Seunghwan Kim, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo JangABSTRACTBackgroundIntensive statin therapy reduces cardiovascular events in acute coronary syndrome. The data concerning the long-term clinical impacts of statin therapy between ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) after drug-eluting stents (DES) implantation are limited. We compared the 2-year clinical outcomes between these two groups after statin therapy.MethodsA total of 30616 Korean acute myocardial infarction (AMI) patients were enrolled. Among them, 13686 patients were classified as the group A (STEMI statin user), 3824 patients were as the group B (STEMI statin non-user), 10398 patients were as the group C (NSTEMI statin user), and 2708 patients were as the group D (NSTEMI statin non-user). The major clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), and any repeat revascularization during a 2-year follow-up period.ResultsAfter adjustment, the cumulative risks of MACE (adjusted hazard ratio [aHR] = 1.112 [1.002-1.235]; P = 0.047), all-cause death (aHR = 1.271 [1.054-1.532]; P = 0.012), and target vessel revascularization (TVR, aHR = 1.262 [1.049-1.518]; P = 0.014) in the group C were significantly higher than group A. The cumulative risks of MACE, all-cause death, and cardiac death of the statin non-user group (group B and D) were significantly higher compared with statin user group (group A and C).ConclusionsStatin therapy was more effective in reducing the cumulative risks of MACE, all-cause death, and TVR in the STEMI group than NSTEMI group in Korean AMI patients after successful DES implantation.
       
  • Thoracic Splenule (Posttraumatic Autotransplantation of Splenic Tissue)
    • Abstract: Publication date: Available online 5 December 2019Source: The American Journal of the Medical SciencesAuthor(s): Abdulmonam Ali, Naga Srinivas Sirikonda
       
  • Effects of Half- or Whole-Night Shifts on Physiological and Cognitive
           Parameters in Women
    • Abstract: Publication date: Available online 5 December 2019Source: The American Journal of the Medical SciencesAuthor(s): Pinar Cakan, Sedat YildizABSTRACTBackgroundThe study assessed the effects of whole- or half-night shifts on leptin, melatonin, sex hormones, interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), IL-6, hematological parameters, sleep quality and attentional performance in women working in the health sector.Materials and MethodsWomen working whole-night shifts (16:00-08:00 hours, n = 20), half-night shifts (16:00-24:00 hours, n = 20) or day shifts (08:00-16:00 hours, n = 20) participated in the study. Blood pressure, respiratory rate, proximal skin temperature (forehead), blood glucose, leptin, melatonin, estradiol, progesterone, IL-1β, TNF-α, and IL-6 concentrations, complete blood count and erythrocyte sedimentation rate (ESR) were measured in the beginning and at the end of the shifts. The participants filled in sleep quality questionnaires and performed visual attention tests.ResultsHalf- and whole-night shifts caused problems in sleep duration and quality and disturbed the melatonin rhythm. Women working both half- and whole-night shifts had significantly higher nucleated erythrocytes (P = 0.006), eosinophils (P = 0.031), lymphocytes (P = 0.001) and leptin concentrations (P = 0.001) but had lower ESR (P = 0.046) and neutrophil percentage (P = 0.001) than that of day-time workers. Whole-night shifts caused additional changes including lower attentional performance (P = 0.035), lower platelet counts (P = 0.000) and lower estradiol levels (P = 0.029), but higher TNF-α levels (P = 0.000), than the control group. Moreover, whole-night shifts increased IL-1β levels before the shift (P < 0.001) and increased IL-6 levels over the half-night shifts (P < 0.05).ConclusionsHalf-night shifts disturbed sleep parameters and the melatonin rhythm, perturbed blood cell turnover and increased leptin levels. Whole-night shifts caused additional problems including suppressed estradiol, activated inflammatory responses and decreased visual attention. All together, the data suggest that night shifts, especially whole-night shifts, should be refrained from or countermeasures should be taken.
       
  • The American Journal of the Medical Sciences—A Repository of the
           History of American Medicine
    • Abstract: Publication date: Available online 5 December 2019Source: The American Journal of the Medical SciencesAuthor(s): Jesse Roman
       
  • In Memoriam John Alexander Oates, III
    • Abstract: Publication date: December 2019Source: The American Journal of the Medical Sciences, Volume 358, Issue 6Author(s): Jim C. Oates
       
  • A Rare Case of Bronchopulmonary Sequestration Masquerading as Lung Abscess
    • Abstract: Publication date: December 2019Source: The American Journal of the Medical Sciences, Volume 358, Issue 6Author(s): Abdulmonam Ali, Yousef Abdel-Aziz, Youngsook Yoon
       
  • A Gaseous Kidney and Ureter
    • Abstract: Publication date: December 2019Source: The American Journal of the Medical Sciences, Volume 358, Issue 6Author(s): Po-Han Huang, Jyh-Tong Hsieh, Chih-Yu Yang
       
  • Risks of Prescription Sharing
    • Abstract: Publication date: December 2019Source: The American Journal of the Medical Sciences, Volume 358, Issue 6Author(s): Amara Sarwal, Vidya Menon, Isaiarasi Gnanasekaran
       
  • Gut Microbial Metabolite Trimethylamine N-Oxide Is Related to Thrombus
           Formation in Atrial Fibrillation Patients
    • Abstract: Publication date: December 2019Source: The American Journal of the Medical Sciences, Volume 358, Issue 6Author(s): Dingxu Gong, Lin Zhang, Ying Zhang, Fang Wang, Zhenwen Zhao, Xianliang ZhouABSTRACTBackgroundAtrial fibrillation (AF) is the most prevalent cardiac arrhythmia. Patients with AF are prone to forming cardiac thrombi. Elevated serum trimethylamine N-oxide (TMAO) levels are associated with increased thrombosis risk. No previous studies have examined the relationship between serum TMAO levels and thrombus formation in AF patients.Materials and MethodsA total of 117 consecutive rheumatic heart disease patients with AF were enrolled. The patients were divided into 2 groups: patients with thrombi (n = 25) and patients without thrombi (n = 92). Platelet function tests were performed by light transmittance aggregometry. Serum TMAO, betaine and choline levels were quantified by liquid chromatography combined with tandem mass spectrometry. Results were compared between the 2 groups. The correlation between serum TMAO levels and thrombi formation was examined.ResultsNo remarkable differences in demographic characteristics were found between the 2 groups. Serum TMAO levels were significantly higher in the thrombus group (4.55 UM [3.19-4.83] vs. 3.53 UM [2.96-4.25], P = 0.01). Enhanced platelet hyperreactivity was more likely in the thrombus group. Receiver operating characteristic analysis showed the diagnostic potential of serum TMAO levels to identify thrombus formation, with an area under the curve of 0.661 (P = 0.01, 95% confidence interval: 0.52–0.80). Binary regression analyses showed that serum TMAO had potent predictive power for thrombus formation (P < 0.01, 95% CI of 1.21-3.08).ConclusionsElevated serum TMAO levels were predictive of thrombus formation in AF patients. Our results highlight the usefulness of serum TMAO levels in identifying individuals with increased susceptibility to thrombus formation, allowing development of precise thrombus prevention strategies.
       
  • Evaluation of Efficacy and Safety for Lentinan in the Control of the
           Malignant Pleural Effusions via Intrapleural Injection
    • Abstract: Publication date: December 2019Source: The American Journal of the Medical Sciences, Volume 358, Issue 6Author(s): Qi Congcong, Zhu Hengting, Li Shuhui, Yuan Fang, Wang ShanABSTRACTBackgroundMany studies have investigated the efficacy and safety of lentinan combined with cisplatin versus cisplatin alone for controlling malignant pleural effusion (MPE). This study is a meta-analysis of available evidence.Materials and MethodsSeventeen studies reporting lentinan combined with cisplatin versus cisplatin alone for controlling MPE were reviewed. Pooled odds ratios and hazard ratio with 95% confidence intervals were calculated using the fixed effects model of meta-analysis.ResultsThe overall response rate (ORR) of lentinan combined with cisplatin for controlling MPE was significantly higher than that of cisplatin alone (P < 0.001). In addition, lentinan combined with cisplatin showed a better benefit of quality of life (QOL) compared with cisplatin alone (P < 0.001). The main adverse effects (AEs) found in the control plan were hematological reactions, nausea/vomiting, chest pain and fever. However, the presence of lentinan did not have an extra influence on the incidence of AEs (P> 0.05).ConclusionsIntrapleural injection of lentinan combined with cisplatin had a better benefit of ORR and QOL for controlling MPE, compared with cisplatin alone. Moreover, lentinan combined with cisplatin had a similar incidence of AEs with cisplatin alone.
       
  • Choosing to Use Care as a Verb, Rather Than a Noun
    • Abstract: Publication date: December 2019Source: The American Journal of the Medical Sciences, Volume 358, Issue 6Author(s): Edward C. Halperin
       
  • Cardiogenic Pulmonary Edema
    • Abstract: Publication date: December 2019Source: The American Journal of the Medical Sciences, Volume 358, Issue 6Author(s): Logan Dobbe, Rubayat Rahman, Mohamed Elmassry, Pablo Paz, Kenneth NugentABSTRACTThe initial events in cardiogenic pulmonary edema involve hemodynamic pulmonary congestion with high capillary pressures. This causes increased fluid transfer out of capillaries into the interstitium and alveolar spaces. High capillary pressures can also cause barrier disruption which increases permeability and fluid transfer into the interstitium and alveoli. Fluid in alveoli alters surfactant function and increases surface tension. This can lead to more edema formation and to atelectasis with impaired gas exchange. Patients with barrier disruption have increased levels of surfactant protein B in the circulation, and these levels often remain high after the initial clinical improvement. Routine clinical assessment may not identify patients with increased extravascular fluid in the lungs; pulmonary ultrasound can easily detect pulmonary edema in patients with acute decompensation and in patients at risk for decompensation. Studies using serial pulmonary ultrasound could help characterize patients with cardiogenic pulmonary edema and help identify subgroups who need alternative management. The conventional management of cardiogenic pulmonary edema usually involves diuresis, afterload reduction and in some cases noninvasive ventilation to reduce the work of breathing and improve oxygenation. Patients with persistent symptoms, abnormal chest x-rays and diuretic resistance might benefit from alternative approaches to management. These could include beta agonists and pentoxifylline which warrant more study in patients with cardiogenic pulmonary edema.
       
  • Chronic, Silent Microaspiration Masquerading as Interstitial Lung Disease
    • Abstract: Publication date: December 2019Source: The American Journal of the Medical Sciences, Volume 358, Issue 6Author(s): Biplab K. Saha, Aditi Saha, Llewellyn A. Foulke, Scott BeegleAbstractChronic, silent microaspiration is a common but underrecognized pathologic process in pulmonary medicine. The clinical presentation is variable and diagnosis can be challenging. We present the case of a 55-year-old woman with known emphysema, who was referred to us for progressive respiratory failure that was unresponsive to therapy. The patient had 9 hospital admissions in the preceding 5 months and was treated with multiple courses of antibiotics and systemic steroid therapy for a diagnosis of cryptogenic organizing pneumonia. The steroid therapy was complicated by 51 pounds of weight gain. She had conversational as well as profound exertional shortness of breath. Physical examination revealed a woman in moderate distress and bilateral diffuse wheezing and rhonchi. Computed tomography of the chest revealed areas of bronchocentric consolidation and bronchial wall thickening in the bilateral lower lobes. She underwent surgical lung biopsy and the histopathology was consistent with chronic aspiration pneumonia.
       
  • Evolutionary Medicine of Retroviruses in the Human Genome
    • Abstract: Publication date: December 2019Source: The American Journal of the Medical Sciences, Volume 358, Issue 6Author(s): Yukako Katsura, Satoshi AsaiABSTRACTHumans are infected with many viruses, and the immune system mostly removes viruses and the infected cells. However, certain viruses have entered the human genome. Of the human genome, ∼45% is composed of transposable elements (long interspersed nuclear elements [LINEs], short interspersed nuclear elements [SINEs] and transposons) and 5-8% is derived from viral sequences with similarity to infectious retroviruses. If integration of retrovirus occurs in a germline, the integrated viral sequences are heritable. Accumulation of viral sequences has created the current human genome. This article summarizes recent studies of retroviruses in humans and bridges clinical fields and evolutionary genetics. First, we report the repertories of human-infective retroviruses. Second, we review endogenous retroviruses in the human genome and diseases associated with endogenous retroviruses. Third, we discuss the biological functions of endogenous retroviruses and propose the concept of accelerated human evolution via viruses. Finally, we present perspectives of virology in the field of evolutionary medicine.
       
  • A Hooked Worm!
    • Abstract: Publication date: Available online 30 November 2019Source: The American Journal of the Medical SciencesAuthor(s): Satvinder Singh Bakshi, B. Sajeeth Manikanda Prabu
       
  • The Characteristics of Intestinal-barrier Damage in Rats with IgA
           Nephropathy
    • Abstract: Publication date: Available online 30 November 2019Source: The American Journal of the Medical SciencesAuthor(s): Nan Zhou, Ying Shen, Lirong Fan, Qiang Sun, Canxing Huang, Jing Hao, Jingchao Lan, Huimin YanAbstractBackgroundIntestinal-barrier damage plays an important pathogenic role in immunoglobulin A nephropathy (IgAN). In this study, we explored the characteristics of the intestinal barrier in rats with IgAN.MethodsWe randomly divided 17 Sprague Dawley (SD) male rats into a normal control group (NC; n = 9) and an IgAN model group (n = 8). Feces in the distal ileum were taken for intestinal-microbiota 16sDNA sequencing. We also took a segment of terminal ileum to analyze intestinal morphology and to detect mRNA and protein expression of the tight-junction proteins (TJPs) zonula occludens-1 (ZO-1) and occludin (OCLN), as well as of mucin 2 (MUC2). We then measured levels of serum diamine oxidase (DAO) and D-lactic acid (D-LA), the biomarkers of intestinal permeability.ResultsCompared with the NC group, mRNA expression levels of ZO-1 (t = 4.216, P = 0.0007), OCLN (t = 2.413, P = 0.029) and MUC2 (t = 0.859, P < 0.0001) were significantly decreased in the IgAN model group. Protein expression of ZO-1 (t = 7.349, P < 0.0001) and OCLN (t = 6.367, P < 0.0001) was also decreased in the IgAN model group. Conversely, serum DAO (t = 3.758, P = 0.0024) and D-LA (t = 2.246, P = 0.0427) levels increased in this group. At the genus level, the relative abundance of Ruminococcus2 (P = 0.0086) was increased in the IgAN model group.ConclusionsDecreased expression of ZO-1, OCLN, and MUC2, plus intestinal-microbiota dysbiosis, might have been associated with intestinal-barrier damage in IgAN rats.
       
  • Bilateral Scrotal Masses as a Clue to Diagnosis of Genetic Disease
    • Abstract: Publication date: Available online 30 November 2019Source: The American Journal of the Medical SciencesAuthor(s): Sakditad Saowapa, Touch Ativitavas, Chutintorn Sriphrapradang
       
  • THE EVOLUTION OF THE ENZYMATIC DIAGNOSIS OF MYOCARDIAL INFARCTION
    • Abstract: Publication date: Available online 29 November 2019Source: The American Journal of the Medical SciencesAuthor(s): Todd M. Brown, Sumanth D. Prabhu
       
  • TGF-β and Diabetic Nephropathy: Lessons Learned over the Past 20
           Years
    • Abstract: Publication date: Available online 29 November 2019Source: The American Journal of the Medical SciencesAuthor(s): Leslie S. Gewin
       
  • Actin-bundling proteins (actinin-4 and fascin-1) are involved in the
           development of pancreatic intraepithelial neoplasia (PanIN)
    • Abstract: Publication date: Available online 29 November 2019Source: The American Journal of the Medical SciencesAuthor(s): Magdalena Misiura, Justyna Zińczuk, Konrad Zaręba, Dorota Kamińska, Katarzyna Guzińska-Ustymowicz, Anna PryczyniczAbstractBackgroundFascin-1 and actinin-4 are involved in key processes of tumor cell adhesion, migration and metastasis. Actinin-4 plays an important role in promotion of cell proliferation, whereas fascin-1 regulates cellular motility. Its over-expression leads to the loss of cell adhesion and metastasis. The aim of our study was to assess fascin-1 and actinin-4 expression in normal pancreatic ducts and in pancreatic intraepithelial neoplasia (PanIN) – precursor lesion of pancreatic ductal adenocarcinoma (PDAC).MethodsThe study involved 70 patients treated surgically due to PDAC, cysts and pancreatitis, who had also been diagnosed with pancreatic intraepithelial neoplasia. Fascin-1 and actinin-4 expressions were evaluated using the immunohistochemistry method.ResultsA statistically significant relationship was observed between the expression of fascin-1 and actinin-4 (cytoplasmic) and patients’ age (P = 0.01, P = 0.002, respectively). The expression of fascin-1 and actinin-4 was associated with the diagnosis (P < 0.001, P = 0.04, respectively). Statistical analysis revealed correlations of fascin-1 and actinin-4 expressions with the presence and grade of PanIN (P < 0.001, P = 0.002, respectively). The expression of these proteins was observed in each degree of PanIN and increased with the pancreatic intraepithelial neoplasia progression.ConclusionsThe expression of fascin-1 and actinin-4 is connected with the degree of PanIN advancement and depends on the type of the primary disease. Overexpression of these proteins may be linked to cytological and architectural abnormalities observed in advanced PanIN. Elevated expression of fascin-1 and actinin-4 indicates the role of these proteins in the progression from PanIN to PDAC.
       
  • Triple negative mutations in essential thrombocythemia with bcr-abl
           rearrangement: Is there a such distinct disease'
    • Abstract: Publication date: Available online 28 November 2019Source: The American Journal of the Medical SciencesAuthor(s): Andrei Braester, Masad Barhoum
       
  • THE AJMS IN THE BEGINNING – NATHANIEL CHAPMAN, WILLIAM OSLER, AND
           THE PHILADELPHIA STORY
    • Abstract: Publication date: Available online 28 November 2019Source: The American Journal of the Medical SciencesAuthor(s): Salvatore Mangione
       
  • The AJMS Celebrates # 200!
    • Abstract: Publication date: Available online 27 November 2019Source: The American Journal of the Medical SciencesAuthor(s): Suzanne Oparil
       
  • Renal lipid metabolism and lipotoxicity in diabetes
    • Abstract: Publication date: Available online 25 November 2019Source: The American Journal of the Medical SciencesAuthor(s): Laongdao Thongnak, Anchalee Pongchaidecha, Anusorn LungkaphinAbstractThe pathogenesis of diabetic kidney disease is a complex process caused by both glucotoxicity and lipotoxicity, due to lipid accumulation. In cases of diabetic animals, lipid deposition is found in both tubular and glomerular portions of the kidneys, which are the major sites of diabetic nephropathy lesions. The aim of this review was to provide insights into the mechanisms that lead to the development of renal lipid accumulation and the effects of renal lipotoxicity in the diabetic condition. An increased number of lipogenic genes and a decreased number of lipid oxidation genes are also detected in diabetic kidneys, both of which lead to lipid accumulation. The induction of oxidative stress, inflammation, fibrosis, and apoptosis caused by lipid accumulation and lipid metabolites is called lipotoxicity. Renal lipotoxicity due to derangement in lipid metabolism may be a pathogenic mechanism leading to diabetic nephropathy and renal dysfunction.
       
  • Uric acid level as a predictor of long-term mortality in advanced age
           population
    • Abstract: Publication date: Available online 7 November 2019Source: The American Journal of the Medical SciencesAuthor(s): Marwan Abu Sneineh, Yuval Schwartz, Gideon Nesher, Yossi Freier Dror, Gabriel S. BreuerAbstractBackgroundHyperuricemia is associated with the development, progression and outcome of several diseases. The purpose of this study is to evaluate the serum uric acid (UA) levels as predictor of long-term mortality in older population (age 60 years and above).MethodsPatients older than 60 years who were hospitalized in the departments of geriatrics and internal medicine in Shaare Zedek Medical Center in Jerusalem during a period of 4 months (March-June 2014) were included in this observational study. Association between hyperuricemia and long-term mortality were analyzed using multiple logistic regression, Kaplan-Meier and Cox proportional hazards regressions analysis.ResultsA total of 624 patients were included in our study with mean age of 77.2 ± 14.6 years. Overall, 381 patients died during the follow up period (61.1%). Mortality rate in the hyperuricemic group (> 7 mg/dl) was higher (69.1%) than in the normo-uricemic group 58.4%. (P = .004). The median survival for hyperuricemic patients was significantly shorter compared to normo-uricemic patients (606 and 1018 days, respectively, P < .0001). High levels of UA were significantly associated with higher long-term mortality in patients with cardiovascular disease at their admission (P < .000).ConclusionsElevated levels of UA in older patients in acute settings is a predictor of long-term mortality.
       
  • Pulmonary Mycobacterium Spindle Cell Pseudotumor in Patient with Liver
           Transplant
    • Abstract: Publication date: Available online 5 November 2019Source: The American Journal of the Medical SciencesAuthor(s): Supavit Chesdachai, Prowpanga Udompap, Faqian Li, John R Lake, Mandip KCAbstractWe report a case of liver transplant patient who presented with lung masses, found to be Mycobacterium spindle cell pseudotumors. The masses demonstrated hypermetabolic activities on positron emission tomography. Core biopsy revealed sheets of spindle histiocytic cells with abundant acid-fast bacilli identified as Mycobacterium avium-intracellulare complex. This finding is a rare presentation of Mycobacterium infection, mainly non-tuberculous Mycobaterium. It is characterized by a benign, spindle cell mass-forming reaction. Most of the reported cases had acquired immune deficiency syndrome or organ transplant. Histopathology illustrating the proliferation of spindle cell shaped histiocytes containing numerous acid-fast bacilli is the gold standard for diagnosis. The standard treatment has not been well established; previously reported cases followed the standard treatment for Mycobacterium based on organ involvement. Our case is the first case to our knowledge that reports pulmonary Mycobacterium spindle cell pseudotumors in a liver transplant recipient.
       
  • Severe pneumonia advanced to lung abscess and empyema due to Rothia
           mucilaginosa in an immunocompetent patient
    • Abstract: Publication date: Available online 5 November 2019Source: The American Journal of the Medical SciencesAuthor(s): Ling Yang, Ting Liu, Bi-Cui Liu, Chun-Tao Liu
       
  • Differential expression of renin-angiotensin system-related components in
           patients with rheumatoid arthritis and osteoarthritis
    • Abstract: Publication date: Available online 5 November 2019Source: The American Journal of the Medical SciencesAuthor(s): Yuangang Wu, Mingyang Li, Jun Zeng, Zhanzhan Feng, Jing Yang, Bin Shen, Yi ZengAbstractBackgroundThe purpose of this study was to demonstrate the role of renin-angiotensin system (RAS)-related components, vascular endothelial growth factor (VEGF) and atrial metalloproteinase-13 (MMP-13) in synovial tissue and synovial fluid from patients with rheumatoid arthritis (RA) and osteoarthritis (OA).MethodsThirty-four patients with RA and 41 patients with OA were included in the study. Renin, angiotensin-converting enzyme (ACE), VEGF and MMP-13 protein levels in the synovial fluid were measured by enzyme-linked immunosorbent assay (ELISA). qRT-PCR analysis, western blot analysis and immunohistochemistry were used to quantify renin, ACE, angiotensin type 1 and type 2 receptors (AT1R and AT2R), VEGF and MMP-13 in OA and RA. Additionally, the correlation was determined by Pearson's coefficient.ResultsIn synovial fluid, expression levels of renin, ACE, VEGF and MMP-13 in patients with RA were significantly higher than those in patients with OA. In synovial tissue, the RAS components VEGF and MMP-13 were also elevated in patients with RA. The results of immunohistochemistry in synovial tissue also showed that the RAS components VEGF and MMP-13 were significantly increased in patients with RA. Notably, the Pearson coefficient demonstrated that the levels of the RAS components were positively correlated with the expression of VEGF and MMP-13 in OA and RA.ConclusionsThe present results suggest that RAS-related components in RA and OA, including renin, ACE, AT1R and AT2R, are associated with increased expression of VEGF and play an important role in angiogenesis. Furthermore, there was a significant positive correlation between the expression of VEGF and MMP-13.
       
  • Hydrogen Studies at ClinicalTrials.gov: The Dawn of a New
           Era'
    • Abstract: Publication date: Available online 28 October 2019Source: The American Journal of the Medical SciencesAuthor(s): Sergej M. Ostojic
       
  • Girolamo Fabrici d'Acquapendente and the Oplomochlion: the several
           applications of an effective rehabilitation tool
    • Abstract: Publication date: Available online 24 October 2019Source: The American Journal of the Medical SciencesAuthor(s): Carlo Biz, Alessandro Brunati, Elisa Belluzzi, Pietro Ruggieri, Stefano Masiero, Maurizio Rippa BonatiAbstractGirolamo Fabrici d'Acquapendente (1533-1619) was an Italian anatomist, surgeon and physiologist and a protagonist of the scientific revolution of the Renaissance. He made anatomy a scientific discipline and is justly considered a precursor of modern orthopaedics. He invented and used several external corrective devices for the treatment of congenital and acquired deformities of the limbs and spinal column, especially those following tubercular infection and rickets, torticollis, vertebral caries kyphosis, scoliosis, and rachitic deformities of the leg, but also congenital dislocation of the hip and congenital club-foot. He ascribed the pathogenesis of the equinovarus supinated foot to the position taken by the foot of the fetus during intrauterine life. The Oplomochlion, shown in the Operationes chirurgicae and attributed to Fabrici, is actually a collection of very diverse orthotic, prosthetic and surgical metal instruments invented by Fabrici and arranged with a demonstrative purpose and a topographic criterion, as if on an exhibition dummy.
       
  • SSCI Presidential Symposium Presented at the SRM in 2019: HIV- mediated
           tissue injury in the era of anti-retroviral therapy
    • Abstract: Publication date: Available online 23 October 2019Source: The American Journal of the Medical SciencesAuthor(s): David M. Guidot, Jeffrey R. Pine
       
  • SYMPOSIUM ARTICLE: HIV and the kidney: From HIV-associated nephropathy to
           reservoir
    • Abstract: Publication date: Available online 23 October 2019Source: The American Journal of the Medical SciencesAuthor(s): Mary Klotman
       
  • 2019 SSCI Presidential Symposium Lung and kidney disease in people living
           with HIV: Section 1: HIV-related Lung Disease
    • Abstract: Publication date: Available online 23 October 2019Source: The American Journal of the Medical SciencesAuthor(s): Sushma K. Cribbs
       
  • The potential protective effects of diosmin on streptozotocin-induced
           diabetic cardiomyopathy in rats
    • Abstract: Publication date: Available online 22 October 2019Source: The American Journal of the Medical SciencesAuthor(s): Tarek Mohamed Ali, Osama M. Abo-Salem, Basem Hassan El Esawy, Ahmed El AskaryAbstractBackgroundDiabetic cardiomyopathy (DCM) is a non-ischemic myocardial disorder characterized by metabolic disturbances and oxidative stress in diabetic patients. The present paper aims to determine the protective effect of the phlebotrophic drug, diosmin, on DCM in a model of high-fat diet-fed and streptozotocin-induced type 2 diabetes in the rat.Materials and MethodsThe animals were divided into 4 groups (8 rats/group) as follows: vehicle-treated non-diabetic control group, vehicle-treated diabetic group, diosmin (50 mg/kg)-treated diabetic group and diosmin (100 mg/kg)-treated diabetic group. Treatment was given once daily orally by gavage for 6 weeks. Oxidant and anti-oxidant stress markers, inflammatory markers and pro-apoptotic and anti-apoptotic gene expression using quantified real-time polymerase chain reaction were investigated.ResultsDiosmin treatment in diabetic rats lowered elevated blood glucose levels, homeostatic model assessment for insulin resistance, cardiac creatine kinase and lactate dehydrogenase enzymes, cardiac malondialdehyde and nitric oxide. Moreover, diosmin increased plasma insulin and c-peptide levels, cardiac glutathione content, superoxide dismutase, catalase, and glutathione S-transferase activities. Also, diosmin treatment significantly (P < 0.05) lowered the levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), down-regulated cardiac Bcl-2-associated X protein and caspase 3 and 9 and up-regulated B-cell lymphoma 2 mRNA expression levels.ConclusionsDiosmin may have a sizeable therapeutic potential in the treatment of DCM due to antidiabetic, antioxidative stress, anti-inflammatory, and anti-apoptotic effects. Detailed studies are needed to disclose the precise mechanisms motivating the protective effect of diosmin‏.
       
 
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