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International Journal of Research in Dermatology
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2455-4529
Published by Medip Academy Homepage  [12 journals]
  • Evaluation of platelet-rich plasma on infraorbital dark circles by using
           the FACE-Q scales

    • Authors: Kadri Ozer, Ozlem Colak
      Pages: 224 - 230
      Abstract: Background: Infraorbital dark circles, also referred to as idiopathic cutaneous hyperchromia of the orbital region, periorbital melanosis, periorbital hyperpigmentation or infraorbital pigmentation, is a common condition frequently observed in dark-skinned patients, but has little data in scientific literature. We aimed to discuss our results of PRP procedure in the treatment of infraorbital dark circles using objective scales based on patient satisfaction and the quality of life.Methods: Between 2016 and 2017, 9 patients complaining of infraorbital darkness were included who underwent 3 sessions of platelet-rich plasma injection. The outcome was determined by the difference in pre- and post- procedure FACE-Q modules which were designed as patient-reported outcome instrument to evaluate the unique outcomes of patients undergoing facial cosmetic procedures. Surveys conducted were modules of satisfaction with facial appearance, satisfaction with skin, psychological function, social function, aging appearance appraisal and satisfaction with outcome.Results: All patients were followed up a minimum of 9 months. No major complications were recorded. Only transient ecchymosis and edema were seen in all patients who were improved during follow-up. The patient-reported FACE-Q satisfaction and FACE-Q quality of life pre- and post- procedure results showed statistically significant improvement (<0.05). Overall satisfaction with outcome was 83.33±16.25 (range 63–100).Conclusions: PRP as a potent source of growth factors, can be seen as a safe, biocompatible, autologous and appropriate treatment modality for the dark eye circles formed in lower eye regions which can increase the quality of patients’ lives in terms of social and psychological function.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191001
      Issue No: Vol. 5, No. 2 (2019)
  • Prospective monitoring of cutaneous adverse drug reactions in a secondary
           care hospital, UAE

    • Authors: Fatma Al Mulla, Sathvik B. Sridhar, Ghada Abu Al Hassan, Atiqulla Sharif
      Pages: 231 - 238
      Abstract: Background: Adverse drug reactions (ADRs) are one of the most important causes of morbidity, hospitalization, increased healthcare cost and even mortality. Cutaneous adverse reactions are most commonly documented for drugs. The aim of the study was to monitor the incidence and nature of cutaneous adverse drug reactions (CADRs) in the dermatology outpatients and identify the causative drugs.Methods: A prospective observational study was conducted at the dermatology outpatient department of a secondary care hospital, UAE. All the patients attending dermatology outpatient and satisfying the inclusion criteria were monitored for ADRs. The required data were collected from the patients, their case files, and caretakers and entered in a suitably designed ADR reporting and documentation form. The causality, severity, and preventability of cutaneous ADRs were assessed using Naranjo, WHO, Hartwig and modified Schumock and Thornton scale.Results: The prevalence of cutaneous ADRs was found to be 2.6%. Majority (43.4%) of the cutaneous ADRs were caused by nonsteroidal anti-inflammatory drugs. Majority (56.5%) of the study population reported itching as the most common cutaneous ADR. Also, 60.8% of the reported ADRs were “probable” in nature according to World Health Organization scale, whereas 56.5% reports were “probable” according to Naranjo’s algorithm. Majority (97%) of the ADRs were not preventable.Conclusions: Nonsteroidal anti-inflammatory drugs were the common causes of cutaneous ADRs in the study. Majority of the adverse reactions were mild in nature. The type and nature of cutaneous adverse drug reaction profile documented in this study is almost similar in many ways to other ADRs monitoring studies conducted in dermatology outpatient clinics.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191000
      Issue No: Vol. 5, No. 2 (2019)
  • A mycological study of clinically normal nails and waistbands and their
           role as sources of infection in patients with tinea corporis

    • Authors: Asritha Reddy, Noyal Maria Joseph, Subuh Parvez Khan, Shuaeb Bhat
      Pages: 239 - 242
      Abstract: Background: Dermatophytosis is a superficial fungal infection of keratinized tissue caused by keratophilic fungi- dermatophytes. Inanimate objects and infected nails favour the spread of infection. Purpose of this study was to identify the role of waist bands and uninvolved nails as sources of infection in patients with tinea corporis.Methods: A study was carried out on 50 patients with tinea corporis during the period of December 2010 to June 2012 at Tertiary Care Centre at Pondicherry. Nail clippings, waist band cuttings and scrapings were subjected to direct microscopy with 10% KOH and culture.Results: Laboratory analysis showed positive culture in 18% of patients, of which dermatophytes were isolated from all three samples in 12% of patients, while in 6% of the patients growth was seen only in the skin scrapings and waist bands.Conclusions: Waist bands and uninvolved nails harbour dermatophytes and play an active role in the spread and recurrence of infection.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191763
      Issue No: Vol. 5, No. 2 (2019)
  • Combined treatment modalities in atrophic acne scars: a prospective study

    • Authors: Saravanan Narayanan, Kamalanathan Nallu, Sridhar Venu, Arul Raja Ganapathi
      Pages: 243 - 246
      Abstract: Background: Atrophic acne scars are one of the sequalae that follows acne vulgaris. These scars are big cosmetic concern presenting with varied morphology like ice-pick, rolling and boxcar scars and it needs multimodal approach to treat effectively rather than a single modality. Our main aim is to study the efficacy of combination therapy using subcision, micro-needling and trichloro acetic acid chemical reconstruction of skin scars (TCA CROSS) in a sequential manner for the management of atrophic acne scars.Methods: Total 30 patients of either sex with grade 2, 3, and 4 atrophic acne scars were graded using Goodman and Baron qualitative grading and were enrolled in the study. After single sitting of subcision, micro-needling and 50% TCA CROSS were performed alternatively at 3 weeks interval for a total of 3 sessions of each. Grading of acne scars were done by taking photographs at pre-treatment, post treatment, 1st and 3rd month after last treatment session.Results: Out of 14 patients with grade 4 acne scars, 9 (64.3%) patients improved to grade 2 and 5 (35.7%) patients improved to Grade 3. Out of 10 patients with Grade 3 scars, 6 (60%) patients improved to grade 1, and 4 (40%) patients were improved to grade 2 at the end of study. All 5 patients with Grade 2 scars showed significant improvement from baseline.Conclusions: Subcision, micro-needling and TCA CROSS, if they are combined and adequately done in proper manner will have excellent response in all types of atrophic acne scars.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20190959
      Issue No: Vol. 5, No. 2 (2019)
  • PUVAsol therapy in the management of vitiligo: outcome in a dermatology
           clinic in South-West Nigeria

    • Authors: Patrick O. Echekwube, Olayinka A. Olasode, Emmanuel O. Onayemi
      Pages: 247 - 253
      Abstract: Background: Vitiligo is a depigmentary dermatosis which currently has no cure but there are different treatment options available to treat affected patients with varying results. The aim of the study was to ascertain the effect of PUVAsol therapy offered to adult patients with vitiligo at a tertiary hospital in Nigeria.Methods: All consecutive adult patients with vitiligo who presented at the Obafemi Awolowo University Teaching Hospitals complex, Ile-lfe and gave consent were recruited for the study which was for a period of 6 months. Patients with limited disease were treated with topical PUVAsol and those with extensive disease were treated with oral PUVAsol. The outcome of therapy for the patients was classified into three categories as follows: progressed (P), stable (S) and repigmented (R). The repigmented group was further sub-classified into fair (R1) and good (R2) representing ≤50% and >50% repigmentation of areas affected respectively.Results: After 6 months of therapy, most of the patients (92%) had repigmentation of their lesions while the remaining had either stable lesions (6%) or progression of their lesions (2%). Amongst the patients whose lesions got repigmented, 96% of them had repigmentation in less than half of the areas affected by vitiligo which was a fair outcome.Conclusions: PUVAsol is a treatment modality for vitiligo with some repigmentation of lesions following therapy for 6 months. PUVAsol therapy could be recommended in resource poor settings because of its low cost and availability in most parts of Nigeria.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191759
      Issue No: Vol. 5, No. 2 (2019)
  • A comparative study of efficacy and safety of platelet rich plasma versus
           fractional co2 laser in the treatment of post acne scars

    • Authors: Amita Murali Babu, Vinma H. Shetty, Saumya Goel, Hafsa Eram
      Pages: 254 - 258
      Abstract: Background: Facial scars prompt restorative issues and have mental impacts, for example, humiliation, poor confidence, and social isolation. This study intends to assess efficacy and safety of platelet rich plasma (PRP) versus CO2 laser in post acne scar treatment.Methods: It is an outpatient based comparative study.  All patients enlisted in this study were separated into two groups, ten in each treatment group. In group A, patients received PRP month to month for 3 sittings and followed up eight weeks after the third sitting. In group B, patients received fractional CO2 laser month to month for 3 sittings and followed up eight weeks after the third sitting. Improvement of acne scars was assessed utilizing digital photographs with identical camera settings and Goodman and Baron’s qualitative grading system at beginning, after each sitting and followed up eight weeks after the third sitting. Patients subjectively evaluated clinical improvement eight weeks after the last sitting. Software (SPSS, version 16.0 statistical packages) was used.Results: Assessment using qualitative acne scars grading system prior to and after treatment as well as patient’s subjective assessment 2 months after the third treatment session showed significant improvement in both groups. The baseline scores before treatment for group A and B were similar (p=0.7678) and final scores of both treatment groups showed no significant difference (p=0.8011) after treatment.Conclusions: This study shows that PRP as well as fractional CO2 laser result in significant clinical change in the quality of post acne scars.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191760
      Issue No: Vol. 5, No. 2 (2019)
  • Comparative study of oral methotrexate and narrow band ultraviolet-B in
           chronic plaque psoriasis: a study from urban Karnataka

    • Authors: K. Sindhuri, T. Virupakshappa, Anant A. Takalkar
      Pages: 259 - 263
      Abstract: Background: Treatment of psoriasis continues to be a challenge. It is often frustrating experience for dermatologists. Methotrexate or PUVA or NBUVB when used properly, can produce good to excellent clinical benefit with minimal side effects. The objective of the study was to compare the efficacy and safety of oral methotrexate and NBUVB in the treatment of chronic plaque psoriasis.Methods: 100 patients of chronic plaque psoriasis attending the skin department of Navodaya Medical College and Hospital, Raichur from November 2012 to April 2014 were included in the study. Group A exhibited to Oral methotrexate and group B to NBUVB. Outcome was measured in terms of PASI 75 (it means 75% reduction in original PASI). Data was analysed using SPSS 19.0 version.Results: In Group A mean age was 33.68 years and in Group B mean age 33.7 years. The difference in mean PASI at baseline, at 4 and 8 weeks using oral methotrexate as well as NBUVB was found to be highly significant (<0.001). PASI score was less in-group using methotrexate at 4 and 8 weeks interval (<0.05). Mean time taken for PASI 75 in the baseline PASI score in Group A was 9.62±1.3 weeks whereas in Group B it was 11.3±0.7 weeks. Side effects were higher in group B (60%) compared to group A (36%).Conclusions: Improvement in the PASI score was best with methotrexate than NBUVB. The side effects observed in a methotrexate were minimal compared to NBUVB.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20190480
      Issue No: Vol. 5, No. 2 (2019)
  • The current trend of cutaneous drug reactions at a tertiary care hospital

    • Authors: Naveen Nagaraju, Puneetha .
      Pages: 264 - 271
      Abstract: Background: Cutaneous adverse drug reactions (CADR) are common yet important entity in dermatological clinical practice. This study is to investigate the clinical spectrum of CADR reactions and assess its causality relationship to offending drug.Methods: It was a cross-sectional observational study, conducted at a tertiary care hospital over a period of two years. Total of 200 patients with cutaneous drug rash diagnosed based on detailed history, correlation between drug intake and the onset of rash, thorough clinical examination and laboratory parameters were included and patients without details of drugs were excluded.Results: Among 200 cases, mean age was 33.57 years (6 months to 87 years). The commonest age group was 19-30 years (27%) and Male: female ratio was 0.94:1. The most common morphological pattern was maculopapular rash seen in 46 cases (23%), followed by FDE- 34 (17%), urticaria- 22 (11%), acneiform eruptions- 20 (10%), drug induced hyperpigmentation- 13 (6.5%), EMF- 12 (6%), lichenoid eruptions- 12 (6%), photosensitivity- 11 (5.5%), eczematous dermatitis- 6 (3%), pruritus- 6 (3%), angioedema- 6 (3%) and SJS- 6 (3%), DRESS- 2 (1%), TEN- 2 (1%), DHS and psoriasiform dermatitis in 1 each (0.5%) respectively. The most common drug was analgesics (31.2%), followed by anti-microbials (26.25%), corticosteroids (8.75%), antiepileptics (7.5%), anti-leprosy drugs (7.5%), anti-retroviral drugs (6.87%), antitubercular drugs (3.75%) and other drugs (8.12%).Conclusions: Many dermatological conditions can be induced, imitated or aggravated by drugs hence it is necessary for the health care system to promote periodic reporting to regional pharmacovigilance centres to ensure drug safety for clinician’s awareness.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191086
      Issue No: Vol. 5, No. 2 (2019)
  • Clinico epidemiological study of secondary syphilis: a retrospective study
           from a tertiary care centre in Tamil Nadu

    • Authors: Vijayabhaskar Chandran, Prabahar Periyasamy, Subramanian Kalaivani
      Pages: 272 - 276
      Abstract: Background: Syphilis caused by spirochete Treponema pallidum is a bacterial sexually transmitted infection [STI] with protean manifestations. There is a rising trend of this disease due to changing sexual orientation and behavioural practices. The aim was to study the incidence, age, sex distribution, clinical presentation and serological findings of secondary syphilis in patients attending the Institute of Venereology in a tertiary care centre at Chennai.Methods: Retrospective analysis of data of patients diagnosed as secondary syphilis who attended our institute over a period of 2 years from March 2015 and February 2017 was done. Complete epidemiological, clinical and investigational data were analysed.Results: Among 57,316 patients who attended the STD clinic 459 patients were diagnosed to have syphilis. Among them 11.6% were found to have secondary syphilis with majority falling within the age group of 21 to 30 years. Among the 53 patients with secondary syphilis 94% were males, among which only 30% were married. Males having sex with males were affected more. Out of the various clinical presentations of secondary syphilis macular leisons was most commonly observed. Serological test done showed VDRL and TPHA positivity in 100% of patients with secondary syphilis.Conclusions: There is increased prevalence of secondary syphilis among the males, especially among young unmarried males with homosexual orientation and promiscuity. Observations of this study emphasize the urgent need for implementation of programs to focus on sex education and counselling to the adolescents and young adults who tends to be the vulnerable population in the society.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20190965
      Issue No: Vol. 5, No. 2 (2019)
  • A retrospective study on palmoplantar psoriasis and its associations in a
           tertiary care centre

    • Authors: Saradha K. Perumal, Sudha R. Gopinath
      Pages: 277 - 280
      Abstract: Background: Psoriasis is a chronic immune mediated inflammatory condition of the skin. Palmoplantar psoriasis (PPP) is a clinical variant of plaque psoriasis affecting palms and soles extending to the wrist and the margins of the soles and heels. This study was done to find out the prevalence of palmoplantar psoriasis in our setting. The aim of the study was to determine the prevalence, demographic features and other co-morbidities of the palmoplantar plaque psoriasis in a tertiary care centre.Methods: We conducted retrospective study for a period of one year (January 2017 to December 2017) on palmoplantar plaque psoriasis patients attending the dermatology OPD.Results: Among 552 enrolled psoriasis patients, 85 were clinically diagnosed to have palmoplantar psoriasis. The mean age of the patient was 45 years. Most of them belong to 4th, 5th and 6th decade of life. The male to female ratio was 1:2.26. The duration of the disease was more than one year in 73% of patients at the study time. Occupation of the patients included house-wives (50%), manual labourers (36%) and office goers, (13%). Hyperkeratotic plaque type psoriasis with scaling and fissures was the predominant morphological pattern recorded. Dyslipidemia (22%), overweight and obesity (56%), hypothyroidism (6%) and diabetes mellitus (12%) were the observed co-morbidities in this study.Conclusions: The prevalence of palmoplantar psoriasis (0.09%) was low in our study. Palmoplantar psoriasis affected middle aged adults and had a female predominance in this study. Overweight, obesity, dyslipidemia, diabetes mellitus and hypothyroidism were the co-morbid conditions observed in this study. Being a relapsing and chronic condition the disease poses a poor quality of life than plaque type psoriasis.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20190960
      Issue No: Vol. 5, No. 2 (2019)
  • Clinicopathological and immunofluorescence study of vesiculobullous

    • Authors: Geetha K. Gopalakrishnan, V. Bindu, Najeeba Riyaz
      Pages: 281 - 289
      Abstract: Background: Vesiculobullous diseases are mostly immune mediated and diagnosed based on the clinical features, histology and Immunofluorescence. The aim of the study was to identify the immunofluorescence pattern in auto immune vesiculobullous diseases and correlate it with the clinical profile and histology.Methods: Patients attending the dermatology outpatient department in a tertiary hospital with vesiculobullous diseases, suggestive of auto immune aetiology were evaluated clinically. Histopathology and direct immuno-fluorescence were done in all patients.Results: During the one year period from June 2008 to July 2009, 40 patients with vesiculobullous disorders clinically suggestive of auto immune aetiology attended the outpatient department. Out of the 40 patients, 22 (55%) patients were diagnosed to have intraepidermal with female preponderance and 18 patients (45%) sub epidermal blistering diseases. Bullous pemphigoid was the commonest sub epidermal disease, seen in 8 patients.Conclusions: In all cases diagnosed clinically as pemphigus a histological diagnosis of pemphigus was made (100%). The clinical variants of pemphigus could also be diagnosed in all cases histologically (100%). The positive and negative predictive value was 100% in pemphigus group cases. Histology of all patients showed subepidermal bulla (100%). A specific diagnosis could be made in 18 patients with sub epidermal disease (100%). DIF was found to be an invaluable tool in diagnosing different diseases belonging to the sub epidermal group, but it was not of much help in sub classifying variants of pemphigus. 
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20190912
      Issue No: Vol. 5, No. 2 (2019)
  • Skin disorders among elderly population without comorbidities: a hospital
           based study

    • Authors: Pooja Bains
      Pages: 290 - 294
      Abstract: Background: Aging is a permanent and progressive degenerative process which affects all organs of the body, including skin. There is a structural and physiologic transformation that arises as a result of intrinsic aging along with extrinsic damage which makes elderly skin more vulnerable to dermatologic disorders. In this study, we set out to determine the frequency and pattern of dermatological diseases in geriatric patients without chronic systemic illness and comorbidities like diabetes mellitus, hypertension and cardiac illness.Methods: We enrolled 350 patients of the age 60 years and above who were not suffering from any chronic systemic disease for the study. Baseline information and clinical examination were done to make the diagnosis.Results: The male: female ratio in our study was 1.14:1. The mean age of presentation was 68 year. The minimum age of patient was 60 years and maximum was 92 years. The most frequently encountered diseases in patients were eczematous dermatitis, fungal infections, scabies, xerosis and pruritus. Among eczemas, seborrheic dermatitis was the most common. Very few patients of solar lentigenes, skin tags and seborrheic keratosis came for dermatological consultation.Conclusions: Eczemas were the most common dermatological disease in elderly in our study and pruritus was the most frequent complaint for which elderly visited skin Out Patient Department. Most of the diseases could possibly have been prevented.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20190441
      Issue No: Vol. 5, No. 2 (2019)
  • Alterations in plasma lipid profile and cardiovascular risk indicators in
           clinically sub-grouped psoriasis

    • Authors: S. Srinivas, S. Nagendra, Prashanthkumar Goudappala, R. T. Kashinath
      Pages: 295 - 299
      Abstract: Background: Psoriasis, a chronic skin complication been considered in the recent years by dermatologists as a systemic disease with multi organ abnormalities. Dyslipidemia commonly observed in psoriasis patients may result in cardiovascular complications hence a prompt routine cardiovascular risk evaluation is essential in these patients. A study was designed to assess plasma lipid profile as well as cardiovascular risk markers in psoriasis patients to find out the relationship between cardiovascular risk indicators and psoriasis disease severity.Methods: Study consists of 200 subjects including 100 psoriatics. These psoriatics were sub-grouped based on their increasing PASI score into four groups.Results: The results indicate a significant elevation in lipid parameters and in cadiac risk ratio, atherogenic index of plasma as well as atherogenic coefficient in psoriatics as compared to normal controls. Further a parallel raise has seen in these lipid parameters and risk indicators based on their increasing PASI score.Conclusions: It can be stated from the study results that psoriatics are more affected group for cardiovascular complications and a proper evaluation of cardiovascular risk indicators in these patients is essential in preventing development of cardiovascular risk. Further the risk indicators atherogenic index of plasma and atherogenic coefficient are more promising in evaluating cardiovascular risk in psoriases patients.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20190429
      Issue No: Vol. 5, No. 2 (2019)
  • Association of diabetes and hypertension with elderly skin changes

    • Authors: Gaurav Paliwal, Venkatarao Koti, Shobhit Dutt
      Pages: 300 - 306
      Abstract: Background: The skin is the largest organ of the human body that fulfils multiple essential tasks. It forms the boundary between the inside and outside. It provides protection against mechanical and chemical threats, it provides innate and adaptive immune defences, it enables thermoregulation and vitamin D production, and it acts as the sensory organ of touch. Aging population is susceptible to many cutaneous and systemic diseases, simultaneously leading to impairment of quality of life in them.Methods: A cross sectional study was carried on patients above 60 years of age who visited the dermatology OPD at rural tertiary care centre from November 2016 to May 2017.Results: Total 540 geriatric patients with dermatosis were registered under the study, of these 203 patients had one or more systemic diseases. Hypertension (70.9%) was the commonest disease, followed by diabetes (32.5%).Conclusions: Skin diseases cause considerable morbidity in elderly, particularly if associated with other comorbid conditions, so health promotion and education can do much to reduce the risk. 
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20190561
      Issue No: Vol. 5, No. 2 (2019)
  • Comparative evaluation of oral corticosteroids versus low molecular weight
           heparin in the treatment of lichen planus

    • Authors: Narendar Gajula, Anusha Kalikota, Vontela Rohit, Hiba Shakeer
      Pages: 307 - 313
      Abstract: Background: Lichen planus (LP) is an immunologically mediated inflammatory disorder involving the skin, nails, hair follicles and mucous membranes. Though several drugs and phototherapy are tried and mentioned in the literature, dermatologists are still depending on corticosteroids, which have various serious side effects on long term usage. Thus, in search for an alternative therapy, the present study is conducted to compare the efficacy of systemic corticosteroids and low dose low molecular weight heparin in management of lichen planus.Methods: 60 patients with biopsy proven LP were selected and divided randomly into two groups with 30 patients each. Group 1 was treated with oral corticosteroids and group 2 was treated with low molecular weight heparin for 8 weeks. Follow up was done for a period of 6 months, at monthly intervals in all patients and any relapses if any were noted.Results: 60 patients with biopsy proven LP were selected and divided randomly into two groups with 30 patients each. Group 1 was treated with oral corticosteroids and group 2 was treated with low molecular weight heparin for 8 weeks. Follow up was done for a period of 6 months, at monthly intervals in all patients and any relapses if any were noted.Conclusions: Low dose enoxaparin in the treatment of lichen planus could be considered as an alternative to oral corticosteroids because of equal efficacy and fewer side effects.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191557
      Issue No: Vol. 5, No. 2 (2019)
  • Etiology and immediate drug hypersensitivity in acute urticaria: a
           retrospective study

    • Authors: Priya Prabhakaran Nair
      Pages: 314 - 318
      Abstract: Background: Acute urticaria is an immune mediated or non-immune reaction lasting for less than 6 weeks. This can be caused by food, drugs, infections, physical contact, insect bite but majority are reported to be idiopathic. Theoretically, almost any drug can cause urticaria especially antibiotics like penicillin. We carried out this study to assess the various etiologial factors and to assess the immediate hypersensitivity reaction to various drugs in acute urticaria.Methods: We reviewed the medical records of patients with acute urticaria in dermatology department from 2016 to 2018 (2 years) and recorded the demographic details, history of suspected cause, medications and intradermal drug test report in a standard proforma.Results: There were 154 cases of acute urticaria. Mean age of these cases were 36.48±11.37 years. 13.6% had associated angioedema. Mean duration of urticaria was 21.74±7.92 days. 40.9% cases were labelled idiopathic. Food accounted for 29.2% of the cases, drugs for 23.4% and infection for 5.2%. The rest 1.3% were due to insect bite. Intradermal drug test report showed the following frequency of positive reaction: diclofenac>ciprofloxacin= piroxicam>paracetamol=ketamine=diazepam>promethazine=atracurium.Conclusions: Most cases of acute urticaria were idiopathic whereas food, drugs, infections and insect bite were the specific causes. Fish among food, acetaminophen among drugs and streptococci among infections were most responsible agents. Immediate hypersensitivity to drugs in intradermal test were maximum for NSAIDs especially diclofenac and piroxicam followed by antibiotic namely ciprofloxacin in patients with acute urticaria.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191459
      Issue No: Vol. 5, No. 2 (2019)
  • Quality of life in psoriasis: a clinical study

    • Authors: Prateek Nagrani, Samarjit Roy, Rashmi Jindal
      Pages: 319 - 324
      Abstract: Background: Psoriasis is a common inflammatory dermatosis with a chronic course that can have a significant detrimental effect on the quality of life (QoL) of those suffering from it. We conducted this study to evaluate the effect of psoriasis on QoL and to assess the impact of demographic factors and disease severity on QoL.Methods: Ninety patients attending the Dermatology OPD at Himalayan Institute of Medical Sciences were included in the study. Their demographic details and history were recorded, followed by a physical examination including assessment of disease severity. DLQI was used to measure QoL. T-test and ANOVA were used to study the effect of demographic factors and disease severity on QoL. P<0.05 was considered statistically significant.Results: Out of 90 patients, 61(67.78%) were males and 29 (32.22%) were females. The mean DLQI score was 15.00±4.93. QoL was impacted by age, sex, marital status and disease severity, whereas place of residence and educational status had no correlation with DLQI scores.Conclusions: There is a marked negative impact on QoL of psoriasis sufferers; hence it becomes important to take the psycho-social aspect of the disease into consideration during treatment.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20190481
      Issue No: Vol. 5, No. 2 (2019)
  • A prospective clinical study on homologous autoinoculation in anogenital

    • Authors: Saravanan Narayanan, Kamalanathan Nallu, Sridhar Venu, Muthusubramanian Chandrasekar
      Pages: 325 - 328
      Abstract: Background: Ano-genital wart, an infection of the anal and genital mucosa with their adjoining area is caused by human papilloma virus. Genital warts pose a bigger challenge, because of the lack of cell mediated immunity and its propensity to relapse and the reluctance of patients to consult a physician. The main aim of our study is to determine whether autoinoculation is effective in treatment of ano-genital warts.Methods: 25 cases of anogenital warts of either sex, who attended RTI/STI clinic in Chengalpattu Medical College from September 2017 to September 2018. The study design was prospective. A detailed history taking, thorough clinical examination and appropriate relevant investigations were done for all the patients who fulfilled the inclusion and exclusion criteria. Autoinoculation was done for those patients. They were assessed periodically for clinical outcome.Results: A sample size of 25 patients (20 men and 5 women) was included in the study. After 3 months of therapy 8 (32%) patients recovered completely and more than 75% improvement occurred in another 7 (28%) patients. At 6 months 15 (60%) patients showed complete resolution. No significant complication was documented.Conclusions: Autoinoculation is a single time minimal invasive procedure effective in management of anogenital wart. It also reduces the recurrence of lesions.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20190984
      Issue No: Vol. 5, No. 2 (2019)
  • Therapeutic evaluation of efficacy of intralesional bleomycin in common
           warts including palmo-plantar and periungual warts: a prospective study

    • Authors: Prabal Kumar, Karaninder Singh Mehta, Vikram Mahajan, Pushpinder Singh Chauhan
      Pages: 329 - 337
      Abstract: Background: Commonly used destructive treatment modalities for common warts though effective, are associated with pigmentary changes, scarring and recurrences. Treatment with immune modulators or immunotherapy has shown variable results. We evaluated efficacy and safety of intralesional bleomycin for treating common warts including palmoplantar and periungual warts.Methods: Two hundred patients with common, palmar, plantar and periungual warts (having 753 warts) were treated with two intralesional injections of bleomycin 1 mg/ml at two weekly intervals. They were followed up at 4weeks and 12 weeks for cure, adverse effects and partial clearance or recurrence.Results: Only 183 (M: F 95:88) patients having 703 warts completed the study. Overall, complete clearance in 669 (95.16%) warts in 156 (85.2%) patients and partial clearance in 24 (3.4%) warts in 21 (11.4%) patients were observed. Patients with complete/partial clearance were highly satisfied from the treatment. Recurrence was seen in 6 (3.27%) patients. Most patients had injection site pain for 2-3 days not warranting discontinuation of treatment. Other adverse effects included temporary hyperpigmentation in 46, altered skin texture in 12 and injection site infection in 6 patients, respectively.Conclusions: Intralesional bleomycin appears effective, safe, and acceptable treatment modality for common warts including palmoplantar and periungual warts. It carries the advantage of low dose, insignificant adverse effects and high patient satisfaction. 
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191622
      Issue No: Vol. 5, No. 2 (2019)
  • High sensitivity C-reactive protein, a predictor of cardiovascular
           mortality and morbidity, and psoriasis: a case control study

    • Authors: Surinder Gupta, Preeti Garg, Nikita Gupta, Nakul Gupta
      Pages: 338 - 341
      Abstract: Background: Psoriasis, a chronic inflammatory disease, is associated with systemic comorbidities. The blood levels of various inflammatory markers are increased in psoriasis. One of them is high sensitivity C-reactive protein (hs-CRP). The serum level of hs-CRP is increased in many inflammatory diseases like psoriasis, cardio vascular diseases, infections, arthritis and others. The objectives of the study were to determine serum level of hs-CRP in psoriasis in relation to its PASI score, which is a subjective method to determine severity of the disease, whereas hs-CRP is an objective and more reliable method. And to have a better idea of systemic inflammatory process caused by psoriasis, serum level of hs-CRP was evaluated in psoriasis patients.Methods: A case control study was conducted including 38 patients of chronic plaque psoriasis from dermatology outpatient department of Maharaja Agrasen Medical College (MAMC), Agroha, India, and 38 healthy controls.Results: The serum level of hs-CRP was significantly raised in psoriasis patients (p<0.001). The mean hs-CRP level in psoriasis patients was 6.824±8.562 mg/l whereas it was 1.072±0.929 mg/l in controls. Two observations were noticed, one, the increase in hs-CRP level correlated with PASI score and second, it was much higher in psoriatic patients as compared to controls.Conclusions: The much higher hs-CRP levels in psoriasis as compared to controls and its correlation with severity of psoriasis has led us to propose that this much high hs-CRP is a biomarker of systemic inflammatory process of psoriasis as well as inflamed cutaneous lesions. 
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20190442
      Issue No: Vol. 5, No. 2 (2019)
  • Epidemiological study of skin diseases in Himatnagar

    • Authors: Bhuvnesh Shah, Keya Jayesh Sheth
      Pages: 342 - 345
      Abstract: Background: The aim of the study was to identify the prevalence of skin diseases in the peripheral area of North Gujarat, India.Methods: It was retrograde OPD based study in which patients visiting skin department of GMERS, Himatnagar, were studied from 30 October 2017 to 30 October 2018.Results: Total 15042 patients, male were 53% and female were 47%. Fungal infection was the most common infectious diseases (16.6%) and eczema was the most common non infectious diseases (12.77%). Contact dermatitis accounted (10.49%). Xerosis (8.19%) was the most common in the patients who were in their 5th and 6th decade of life.Conclusions: Fungal infection was seen almost equally in male and female. Contact dermatitis was very common in females. Acne was seen predominantly in teenagers and adolescents due to hormonal changes.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20190453
      Issue No: Vol. 5, No. 2 (2019)
  • Mucocutaneous manifestations in newborn: a study from tertiary care
           centre, Karnataka

    • Authors: T. Virupakshappa, K. Sindhuri, Anant A. Takalkar
      Pages: 346 - 349
      Abstract: Background: The spectrum of dermatological manifestations in neonates varies from era to era and country to country. Skin lesions in neonatal period vary from transient self-limiting conditions to serious dermatoses, requiring specific therapies. Skin lesions are extremely common in newborns and can be a significant source of parental concern. The objective of the study was to study various mucocutaneous lesions in newborn babies.Methods: The present descriptive cross sectional observational study was conducted in department of dermatology, Navodaya Medical College, Raichur. A total 500 neonates were included in the study from January 2012 to September 2013. Data collected and analysed by using SPSS 16.0 version.Results: Prevalence of skin lesions in this study was found to be 97.4%. Maximum skin lesions were observed in 47 subjects (9.4%). Prevalence of Epstein pearls was 58%, Mongolian spots 53.6% and erythema toxicum neonatorum was 28%. Epstein pearls (males 60.2%, female 55.7%) and Mongolian spots (males 53.9%, females 53.3%) predominated.Conclusions: Prevalence of mucocutaneous skin lesions in newborn babies was 97.4%. High prevalence of Epstein pearls (58%), Mongolian spots (53.6%) and erythema toxicum neonatorum (28.6%) were observed.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20190482
      Issue No: Vol. 5, No. 2 (2019)
  • Study of the clinical pattern of contact dermatitis over the face and its
           correlation with patch testing

    • Authors: Saumya Goel, Vinma H. Shetty, Hafsa Eram, Amita Murali Babu
      Pages: 350 - 356
      Abstract: Background: Contact dermatitis (CD) is an altered state of reactivity; occur due to direct contact with noxious agents in our environment. Face is a very common site for CD.Methods: Prospective hospital based study was conducted at A. J. Institute of Medical Sciences, Mangalore from June 2018 to November 2018. Fifty cases aged above 18 years with suspected allergic contact dermatitis (ACD) over face who gave written informed consent were enrolled. A complete history was taken and detailed clinical examination was done. Patch testing was done over the back in all patients which was removed after 48 hours and positive result was recorded based on the recommendation of the international Contact Dermatitis Research Group (ICDRG).Results: The most common clinical pattern observed was pigmented contact dermatitis(PCD) (70%), followed by irritation (6%), acneiform eruptions (5%) and contact urticaria (2%). Out of 50 patients, 20 patients developed CD to fragrances and perfumes. 14 patients developed to soaps and shampoos. On patch testing, most common allergen in fragrances/perfumes was fragrance mix (52.9%). In soaps and shampoos it was triclosan (68.4%), parabens (31.5%). Sesquiterpene lactone in parthenium plant (4%), Paraphenylenediamine in hair dye (8%). In face creams were gallate mix and cetrimide among metals, nickel and chromium (6%). In case of kumkum it was paraphenylenediamine (4%).Conclusions: Amongst the various patterns of contact dermatitis, PCD to cosmetics, fragrances and daily care products was most common pattern observed and the main allergens were triclosan, fragrance mix and balsum of Peru.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191761
      Issue No: Vol. 5, No. 2 (2019)
  • Clinico-epidemiological study of role of patch test in hand eczema

    • Authors: Ashok S. Hogade, P. Anusha
      Pages: 357 - 360
      Abstract: Background: Hand eczema is a common distressing condition in different occupational groups caused by various endogenous and exogenous factors. It appears to be the most common occupational skin disease, comprising 80% or more of all occupational contact dermatitis. Patch test at present is the only scientific method to diagnose the contact allergen and in subsequent management of patient.Methods: An observational study of patch test was conducted on 100 patients of hand eczema in the department of DVL, Basaveshwara Teaching and General Hospital, Kalaburagi. After detailed history and complete examination, patch testing was done using Indian Standard Series and graded by International Contact Dermatitis Research Group criteria at 48 hours and 72 hours.Results: Out of 100 patients, there were 28 females and 72 males. The commonest age group seen was 20-40 years followed by 40-60 years. Commonest sensitizers were to potassium dichromate (34%) followed by nickel (18.7%), Parthenium (12.5%), PPD (7.8%), other (26%). Out of 64 patients who were positive, 82.8% were positive to single allergen, 10% to two allergens and 6.2% to multiple allergens.Conclusions: Patch test is considered as gold standard method for diagnosis of allergic contact dermatitis and thus preventing the morbidity of repeated episodes of eczema.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191762
      Issue No: Vol. 5, No. 2 (2019)
  • Patient perception, satisfaction and cosmetic results of platelet-rich
           plasma in the treatment of acne scars: a patient-reported outcome of a
           non-surgical management

    • Authors: Ozlem Colak, Kadri Ozer
      Pages: 361 - 369
      Abstract: Background: Acne is a common skin condition of the pilosebaceous unit that is prevalent up to 80% of the adolescent population. Permanent, disfiguring scar is an unfortunate complication due to abnormal resolution following the damage during acne inflammation. Those troubling noticeable scars may lead to not only cosmetic problems but also psychological and social consequences which could impair the quality of life including diminished self-esteem and disruption of daily activities. We aimed to discuss our results of PRP procedure in the treatment of acne scars using scales based on patient satisfaction, perception and the quality of life.Methods: This study included 11 patients suffering from post-acne scars who underwent 3 sessions of platelet-rich plasma injection. The outcome was determined by the difference in pre- and post- procedure FACE-Q modules, dermatology life quality index (DLQI) and body image questionnaire (BIQ) which were designed as patient-reported outcome instrument to evaluate the unique outcomes of patients undergoing facial cosmetic procedures.Results: Overall satisfaction with outcome was 77.18±8.30 (range 63–87). No major complications such as hyper-/hypopigmentation, scar formation, infections, skin necrosis, nodulation, fibrosis, or calcification were recorded. All patients developed ecchymosis and edema in the treated area and all were improved during follow-up. The patient-reported FACE-Q satisfaction, FACE-Q quality of life, DQLI and BIQ scores of pre- and post- procedure showed statistically significant improvement (<0.05).Conclusions: PRP can increase the quality of life in patients with acne scars in terms of social and psychological function without large damage to the skin.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191002
      Issue No: Vol. 5, No. 2 (2019)
  • Comparative study of efficacy of glycolic acid (50%) peel and lactic acid
           (92%) peel in the treatment of melasma

    • Authors: Alka Raka, Vinita U. Brahmbhatt
      Pages: 370 - 375
      Abstract: Background: Melasma is difficult to treat in Fitzpatrick skin type IV-VI and recurrence is a big problem.It causes emotional distress to the patient. There is paucity of controlled trials comparing efficacy of two chemical peels Glycolic acid (50%) Vs Lactic acid (92%) with Hydroquinone 2% cream in melasma treatment.Our goal was to determine efficacy and safety of these peels in melasma.Methods: A total 50 newly diagnosed patients of melasma were included in the study, over a duration of 1 year in department of Skin and V.D, M.P. Shah Medical college, Guru Gobindsingh Government Hospital, Jamnagar. All patients were advised daily application of Hydroquinone (2%) cream at night for priming. Patients were divided into two groups.Group1 had 2 weekly lactic acid (LA) peel, while Group 2 had 2weekly Glycolic acid (GA) peel with standard application method. Overall severity was assessed via the pre and post treatment melasma area and severity index (MASI) score. Evaluation for clinical improvement was done by graded score.Results: It was seen in study that at the end of 6 sittings, grade 4 improvement, that is reduction in MASI score by >60% was seen in 27.27% patients in GA peel while 22.72% in LA peel. Amongst the complication noted, in GA peel burning was most common (72.72%) followed by erythema (45.45%). In LA peel only 18.18% showed erythema.Conclusions: Lactic acid peel has almost equal efficacy to Glycolic acid peel, but LA peel has much lesser side effects, leads to increasing the patient compliance, hence making it new peeling agent of choice for treatment of melasma.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191764
      Issue No: Vol. 5, No. 2 (2019)
  • Usefulness of fibro scan in assessing liver fibrosis in adult patients
           with psoriasis

    • Authors: Parimalam Kumar, Suchithra Ganapathi, Athilakshmi Sivasubramanian
      Pages: 376 - 381
      Abstract: Background: Patients with psoriasis are at higher risk of developing “systemic” co-morbidities. Non alcoholic fatty liver disease (NAFLD) is found to be more prevalent among psoriasis patients, where it is closely associated with obesity, metabolic syndrome, and psoriatic arthropathy. Elderly participants with psoriasis are 70% more likely to have NAFLD than those without psoriasis independent of common NAFLD risk factors.Methotrexate is a commonly used drug in the management of psoriasis owing to its cost effectiveness and easy administration. In the presence of NAFLD the choice of potentially hepatotoxic drug therapy, such as methotrexate, should be considered with caution. By assessing the liver stiffness measurement (LSM), such drugs can be prescribed with caution in individual with significant liver fibrosis. We have conducted a study to assess the LSM in patients with psoriasis. Aim was to detect the proportion of liver fibrosis (LSM) in adult patients with psoriasis, which will help in choosing the correct treatment.Methods: Hospital based cross sectional study was conducted in 102 adults with psoriasis who were not treated with methotrexate. Transient elastography (TE) was performed in all and LSM was noted.Results: There was no statistically significant gender influence on LSM in patients with psoriasis. There was significant increase in liver fibrosis in psoriatic patients as age advances.Conclusions: Elderly patients with psoriasis are more likely to have liver fibrosis. Hepatotoxic drugs like methotrexate should be prescribed with caution in such patients, preferably after performing LSM.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191765
      Issue No: Vol. 5, No. 2 (2019)
  • Clinical and histopathological features in lepra reaction: a study of 50

    • Authors: Urvi H. Shah, Monal M. Jadwani, Sahana P. Raju, Pranav H. Ladani, Neela V. Bhuptani
      Pages: 382 - 387
      Abstract: Background: Lepra reactions remain a major persistent problem in leprosy. Type 1 and type 2 (erythema nodosum leprosum-ENL) reactions are the major causes of nerve damage and permanent disabilities. Diagnosing lepra reactions correctly is important for timely institution of therapy to prevent and treat disability and morbidity. Aim and objectives of the study were to make detailed observations on clinical and histopathological features of type1 and type 2 lepra reactions.Methods: In this study we included 50 patients diagnosed during a 1-year period as lepra reactions based on clinic-histopathological corelation.Results: Out of the 50 patients, 4 were of type 1 reaction and 46 of type 2 reaction from which recurrence was more commonly seen with type 2 reactions. The most consistent histopathological findings in type1 reaction were periadnexal inflammatory infiltrates (100%) and lymphocytes in granuloma (100%), followed by papillary dermal edema and intercellular edema within granuloma (75%). Surprisingly, folliculotropism of and lymphocytic panniculitis was seen in 50% cases. In ENL, the most common histological findings were periadnexal inflammatory infiltrates (95.6%), presence of neutrophils within the granuloma (86.9%), foamy macrophages followed by papillary dermal edema (69.5%), and neutrophilic panniculitis (43.4%). Vasculitis like changes was noted in only 46% cases.Conclusions: Infiltration of macrophage granulomas by neutrophils is a reliable sign of ENL. Classical signs of vasculitis are not always present in ENL. Folliculotropism and lymphocytic panniculitis are frequent in type1 reactions while neutrophilic panniculitis is common with ENL.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191766
      Issue No: Vol. 5, No. 2 (2019)
  • Clinical profile of 50 premenopausal women with hirsutism

    • Authors: Sonal Panjwani, Arvind Krishna, Garima Singh, Divya Arora
      Pages: 388 - 392
      Abstract: Background: Hirsutism is a common condition, affecting up to 10% of women and may be associated with signs and symptoms of hyperandrogenism. The aim of this study was to study the clinical characteristics of patients presenting with hirsutism and to correlate the severity of hirsutism with the presence of these features.Methods: A hospital based, cross sectional prospective study was conducted on 50 patients with clinically diagnosed hirsutism. Scoring of hirsutism was done using modified Ferriman –Gallwey scoring system following which a complete history was taken and thorough examination of all patients in the study group was carried out for features associated with hirsutism.Results: Maximum (60%) patients had mild hirsutism, 30% had moderate hirsutism and 10% patients had severe hirsutism. Acne was the most commonly occurring clinical feature, occurring in 50% of the patients followed by menstrual irregularities in 46%, striae and obesity in 42% and acanthosis nigricans in 40% of the patients. Other features seen were androgenic alopecia in 26%, infertility in 16.67% and deepening of voice in 4% of participants.Conclusions: Hirsutism is a multifaceted condition and this study highlights the need for a thorough clinical examination in order to identify possible associated conditions which may provide significant clues for the underlying cause of hirsutism.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191767
      Issue No: Vol. 5, No. 2 (2019)
  • Prevalence of HIV in syphilis in a tertiary care centre

    • Authors: Sumithra Sundararaj, Devaprabha Sendurpandian, Suganthy R. Rajakumari
      Pages: 393 - 396
      Abstract: Background: Aim of this study was to determine the prevalence of HIV in syphilis in patients attending the STD clinic in a tertiary care center.Methods: Study was conducted in all new patients attending the STD clinic during the study period of 6 months from June 2012 to November 2012. Clinically suspected cases of syphilis were diagnosed serologically and all the patients were tested for HIV after proper counselling and consent.Results: In a total of 200 new patients attended the STD clinic 47 (23.5%) were diagnosed as syphilis. Majority of the cases (43) were latent syphilis in our study. A total of 77 (38.5%) cases were reactive to HIV. Among the 47 (23.5%) syphilis cases 24 (51%) were reactive to HIV. In the age group of 21-30 years most of the syphilis male (5/6) patients showed HIV reactivity.Conclusions: Seroprevalence of syphilis among other STI was found to be significant. Rising trend in latent syphilis was noted may be due to antenatal checkup, purpose of foreign job and strict blood screening protocols. The prevalence of HIV in syphilis individual was 51% and it was high in the age group of 31-50 when compared to other age group. In the age group of 21-30 most of the males, diagnosed as syphilis were serologically positive for HIV. Hence these sexually active groups were to be targeted for their safe sexual practice to prevent the transmission of HIV.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191768
      Issue No: Vol. 5, No. 2 (2019)
  • Clinical and histopathological study of postinflammatory hypopigmented
           macular skin lesions

    • Authors: Ashok S. Hogade, N. Sri Hari Reddy
      Pages: 397 - 405
      Abstract: Background: The objective of the study was to study the various etiologies and ascertain different clinicalpresentations of post-inflammatory hypopigmented lesions. Age and sex distribution, socio economic status, seasonal incidence, most common to rare variants amongst all conditions and to correlate them histopathologically.Methods: 100 patients presenting with Post-inflammatory hypopigmented lesions were selected and detailed history and examination was done. Lab investigations and histopathology was done in those cases.Results: Among the various causes of post-inflammatory hypopigmentation, commonly observed conditions were Pityriasis versicolor, mechanical injuries, Pityriasis alba, burns, leprosy, allergic contact dermatitis, morphoea, discoid lupus erythematosus, psoriasis and Steven’s Johnson syndrome. Most common age group affected was in 21-30 years of age. Males (60%) were more than females (40%). People of lower socioeconomic status (55%) presented with post-inflammatory hypo pigmented lesions commonly. History of hypopigmentation ranged from 0-6 months in majority of cases. Upper limbs, trunk and face and neck regions were the most common sites involved. Commonest etiology amongst all cases was pityriasisversicolor, followed by mechanical injuries, PityriasisAlba and burns. Clinical diagnosis correlated with histopathology in these cases.Conclusions: The study concluded that post-inflammatory hypopigmented lesions presented with various manifestations, more common in young, male adults, common in people of lower socioeconomic group. Upper limbs, trunk and face and neck are the common sites involved and histopathology correlated with clinical diagnosis in many cases. 
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191769
      Issue No: Vol. 5, No. 2 (2019)
  • Quality of life in patients with acne vulgaris in a tertiary care centre:
           a cross sectional study

    • Authors: Hafsa Eram, Vinma H. Shetty, Saumya Goel, Amita Murali Babu
      Pages: 406 - 410
      Abstract: Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous units which has great psychological impact and causes depression, anxiety, and low self-esteem.Methods: It was a hospital-based, cross-sectional, prestructured, questionnaire-based study done in 120 individuals in the age group 12-30 years using two specific HRQoL indices-Cardiff Acne Disability Index (CADI) and Acne-specific Quality of Life (Acne-QOL) to understand the impact of acne on the quality of life.Results: Male to female ratio was 2:3. The mean age was 19.23±1.7. The mean CADI score was 5.3. Majority of the patients had grade 2 acne. Based on the CADI questionnaire, the number of males (61.7%) and females (60.2%) was maximum in the medium score. Grade 1 acne had maximum number of patients showing low score followed by grade 2 acne. Based on the acne-QoL questionnaire, maximum patients were in the 11-20 score range, followed by the 21-30 score range.Conclusions: Acne is not only a cosmetic problem, but also has significant psychological impact. Hence, impact of acne on QoL must be considered in the management of facial acne.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191770
      Issue No: Vol. 5, No. 2 (2019)
  • Dermatological changes in pregnancy in central India: a cross sectional

    • Authors: Abhijit Chakraborty, Vaishali H. Wankhade, Bhagyashree B. Supekar, Apoorva D. Chopkar, R. P. Singh
      Pages: 411 - 415
      Abstract: Background: Pregnancy is a period of profound endocrine and metabolic alterations which make the pregnant woman susceptible to changes in the skin and its appendages. These changes in pregnancy can be either physiological, development of pregnancy specific dermatoses or changes in pre-existing skin diseases. The aim of the study to study the dermatological manifestations of pregnancy.Methods: This was a cross sectional study design. All pregnant females with cutaneous manifestations attending outpatient department of Dermato-Venereo-Leprology and Obstetrics and Gynaecology were recruited during December 2015 to October 2017. They were subjected to general, local and systemic examination. Statistical analysis was done with the help percentage, mean and standard deviation.Results: Out of 400 patients, 216 (54%) were primigravidae and 184 (46%) were multigravidae. Majority of the patients (55%) were in the age group of 21-25 years. Physiological changes were present in all patients and specific dermatoses in 8.75% of patients. The commonest mucosal change was Jacquemier-Chadwick Sign (96.5%) followed by gingivitis (2.5%). Most common pigmentary change recorded was linea nigra. Most common specific dermatoses reported was prurigo of pregnancy (8%) followed by pruritic urticarial papules and plaques of pregnancy (0.5%). Prurigo of pregnancy was more frequently recorded in multigravida patients and more frequently in third trimester of pregnancy. The commonest dermatosis not specific to pregnancy observed was dermatophyte infection.Conclusions: Awareness about various cutaneous changes in pregnancy is important for correct diagnosis that will direct the most appropriate laboratory evaluation and careful management in an effort to minimize maternal and fetal morbidity.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191771
      Issue No: Vol. 5, No. 2 (2019)
  • Twenty nail dystrophy with alopecia areata in an atopic child

    • Authors: G. Divya, Jayakar Thomas
      Pages: 416 - 418
      Abstract: Twenty nail dystrophy mainly describes roughness of nail which can be idiopathic or it could be associated with various other dermatological conditions like psoriasis, alopecia areata and eczema. Here we report a case of twenty nail dystrophy with alopecia areata of scalp in a 6-year-old child.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191772
      Issue No: Vol. 5, No. 2 (2019)
  • Aggressive mycosis fungoides/sézary syndrome in Nigeria: case report
           and literature review

    • Authors: Oreoluwa Arowojolu, Oluwasegun Afolaranmi, Mutiu Jimoh
      Pages: 419 - 423
      Abstract: Mycosis fungoides and its variant, sézary syndrome are rare neoplastic conditions which are part of a larger group of lymphomas that primarily affect the skin known as cutaneous T-cell lymphomas. We report a case of fatal aggressive mycosis fungoides/sézary syndrome in a 55-year old Nigerian man who initially developed pruritic hyperpigmented spots on his skin which progressed over the course of 5 years to widespread scaly mixed hyperpigmented and hypopigmented plaques and nodules with features of organ involvement despite being managed with Psoralen and ultraviolet A radiation (PUVA), total skin electron-beam (TSEB), local electron-beam radiation, bexarotene, and oral prednisolone and chlorambucil (Winklemann regimen). In the process, we highlight the rarity of the condition, its ease of misdiagnosis and its predilection for people of Sub-Saharan decent.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191773
      Issue No: Vol. 5, No. 2 (2019)
  • Nail: a window to systemic disease

    • Authors: Anusha Gogula, M. Pooja, P. Karunakar, Chinmai Yerram
      Pages: 424 - 426
      Abstract: Plummer-Vinson syndrome is a rare clinical entity characterized by the triad of iron deficiency anemia, esophageal webs and dysphagia. The condition may manifest with the features like chelitis, glossitis, atropy of papilla over tongue, koilonychia indicating the underlying iron deficiency anemia and vitamin deficiency. We report a case of Plummer-Vinson syndrome presenting with koilonychia and chelitis. Clinical, laboratory and endoscopic evaluation of the patient revealed diagnosis of Plummer-Vinson syndrome. Patient was advised iron supplementation which significantly improved patient’s hemoglobin levels and with that the associated symptoms.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191774
      Issue No: Vol. 5, No. 2 (2019)
  • Renal cyst occurring in a case of Darier’s disease

    • Authors: Vipul Paul Thomas, Sangiah Sivaramakrishnan, Jayakar Thomas
      Pages: 427 - 428
      Abstract: Darier’s disease is a rare genodermatosis inherited in an autosomal dominant pattern. The disease is characterised by chronic persistent hyperkeratotic papular eruptions over the seborrheic regions. 
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191775
      Issue No: Vol. 5, No. 2 (2019)
  • Oral lichen planus with linear lichen planus: a rare association

    • Authors: N. Padmapriya, K. Karthikeyan
      Pages: 429 - 430
      Abstract: Lichen planus (LP) is a papulosquamous disorder with both cutaneous and mucosal manifestation. Linear lichen planus is rare variant of lichen planus which occurs in the extremities. Oral lichen planus is another variant of lichen planus. Coexistence of linear lichen planus with oral lichen planus is rare and only one case has been reported before this case. A 35 year old female presented with hyperpigmented linear lesion in the leg and whitish plaques in the oral cavity. Biopsy of the skin lesions showed features of lichen planus. The patient was started on topical steroids and oral hydroxychloroquine. Patient responded to treatment.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191776
      Issue No: Vol. 5, No. 2 (2019)
  • Photodistributed granuloma annulare responsive to topical corticosteroids

    • Authors: Shibani S. Bhatia, Sudhir U. K. Nayak, Shrutakirthi D. Shenoi, Kanthilatha Pai
      Pages: 431 - 433
      Abstract: Granuloma annulare is a benign granulomatous disorder which is usually of unknown etiology. It is usually known to be associated with diabetes mellitus. It presents in various forms like localized, generalized, subcutaneous and perforating. We report a 52 year old female who presented with annular lesions exclusively over sun-exposed areas and was diagnosed with granuloma annulare. Photodistributed pattern of granuloma annulare has rarely been mentioned in the literature.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191777
      Issue No: Vol. 5, No. 2 (2019)
  • Managing the challenging cases of pemphigus vulgaris with modified pulse
           therapy: case series

    • Authors: Saraswathy P., Jayanthi N. S., Venkatesh Y.
      Pages: 434 - 436
      Abstract: In pemphigus vulgaris, pulse therapy is a promising modality to achieve better therapeutic response and to minimize the side effects of daily steroids. Here we report 5 different challenging situations where we successfully managed with modification of pulse therapy. Our first case had multiple comorbidities with persistent skin infections managed with dexamethasone and cyclophosphamide pulse (DCP) and interval pulse. The second case was unmarried hypertensive male with poor DLQI managed with Azathioprine pulse therapy. The third case was uncontrolled diabetic patient with pulmonary tuberculosis managed with rituximab. The fourth case was diabetic and hypertensive was managed with one day dexamethasone cyclophosphamide pulse therapy (DCP). The fifth case was not completed family with cushingoid features managed with dexamethasone azathioprine pulse therapy (DAP). Pulse therapy is effective in controlling disease activity in pemphigus. But it can be modified in some situations according to the patient needs.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191778
      Issue No: Vol. 5, No. 2 (2019)
  • Cutaneous sarcoidosis with protean manifestations: a rare case report

    • Authors: Avinash Pravin, Shreya Srinivasan, Jayakar Thomas
      Pages: 437 - 439
      Abstract: Sarcoidosis is a multisystem granulomatous disease of unknown origin. The lung is the most commonly affected organ, but skin is frequently involved. Skin involvement is important because it may be the presenting sign of systemic sarcoidosis. Here, we report a rare case of sarcoidosis with systemic manifestations, in a 39 year old male patient.
      PubDate: 2019-04-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20191779
      Issue No: Vol. 5, No. 2 (2019)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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