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International Journal of Research in Dermatology
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2455-4529
Published by Medip Academy Homepage  [12 journals]
  • A 12 weeks, randomized and double-blind evaluation of the efficacy of oral
           supplements of probiotics (Lactogut and Lactogut Kidz) on atopic
           dermatitis in adults and children

    • Authors: B. S. Chandrashekar, Rashmi Agarwal, Preethi B. Nayak, S. Vijayraghavan, Atul A. Deshmukh
      Pages: 604 - 615
      Abstract: Background: The primary objective of the study was to evaluate the efficacy and safety of oral probiotics in the treatment of atopic dermatitis (AD) using the scoring atopic dermatitis (SCORAD) index, serum IgE levels and absolute eosinophil count (AEC). The secondary objective of the study was to determine the association of oral probiotic therapy and improvement in AD using global photographs, dermoscopic images (fotofinder) and individual patient satisfaction.Methods: This was a randomized, double-blind study conducted on 70 patients (20 adults and 50 children) with moderate to severe AD. The participants were randomized into control arm and treatment arm. The treatment arm received conventional and probiotic therapy and only conventional therapy was provided to the control arm. The research was carried out in five visits. For each visit, SCORAD was calculated and response compared using clinical and videodermoscopic images. Patient satisfaction was documented using a quality of life questionnaire during each visit.Results: Across the treatment arm, the mean serum IgE levels were greatly decreased in contrast to the control arm over the 12 weeks period. SCORAD score was significantly lowered in the treatment arm (55.20%) compared with 18.95% in the control arm. Dermoscopic assessment, global photographic assessment and patient satisfaction in the treatment arm showed statistically significant improvement in AD compared to the control arm.Conclusions: The decrease in SCORAD scores demonstrated strong associations with the use of probiotics in patients with AD as an adjunct to conventional therapy. Thus, in both adults and children suffering from moderate to severe AD, probiotic supplement can be administered effectively as an adjunct therapy. 
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203071
      Issue No: Vol. 6, No. 5 (2020)
  • A comparative study of efficacy of resurfacing with fractional carbon
           dioxide laser versus derma roller in the treatment of post acne scars

    • Authors: Francis Abel, Kallappa Herakal, Nikhita Shetty
      Pages: 616 - 621
      Abstract: Background: Acne vulgaris is a chronic skin disease which can present as non-inflammatory lesions, inflammatory lesions, or a mixture of both, resulting in distressing and difficult to treat scars. The objective of this study is to compare the efficacy of fractional carbon dioxide (CO2) laser technique (FCLT) versus derma roller therapy (DT) with respect to post-acne scars and to study their respective side effects.Methods: A total of 200 patients of post acne scars were enrolled for this study from the outpatient Department of   Dermatology, Venereology and Leprology, Navodaya Medical College Hospital and Research Centre, Raichur. The patients were randomly allocated into two groups of 100 patients each in which one group was treated with derma roller therapy and the other group was treated with fractional CO2 laser every 4 weeks over a period of 24 weeks each.Results: In the derma roller group, 89 patients completed the treatment with 11 drop out cases.  The percentage reduction in the mean objective scores was found to be 37.63%. In the fractional CO2 laser group, 93 patients completed the treatment with 7 drop out cases. The percentage reduction in mean objective scores was found to be 41.22%.Conclusions: Comparing the efficacy of derma roller therapy and fractional CO2laser resurfacing method in the treatment of post acne scars, both the modalities were found to be equally efficacious.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203074
      Issue No: Vol. 6, No. 5 (2020)
  • A prospective observational study on efficacy of serial low dose infusion
           of rituximab (500 mg) on patients of pemphigus

    • Authors: Santosh K. Singh, Prasoon Sachan
      Pages: 622 - 627
      Abstract: Background: Rituximab (RTX) is a chimeric anti-CD20 monoclonal antibody being increasingly used in management of pemphigus. Various studies show a lack of any uniform treatment protocol. The objective of the study was to assess the effectiveness of RTX in patients of pemphigus receiving serial low doses of RTX (500 mg; maximum of 4 doses; 2 weeks apart).Methods: It was a prospective observational review of 40 pemphigus patients to assess the proportion of patients achieving complete remission after serially receiving low dose RTX, time and number of doses required to achieve complete remission (CR), proportion of patients who responded partially or didn’t respond or relapsed after achieving CR. Additionally, the study was done to find whether a correlation existed between age, gender, and site of lesion and RTX administration.Results: 40 pemphigus patients followed up for a mean duration (MD) of 174.15±95.67 days received 4 doses of RTX (500 mg) irrespective of the disease activity 0.30 (75%) attained CR on therapy with ≥3 doses of RTX 500 mg (MD= 76.39±34.45 days) and azathioprine 100 mg/day. No patients relapsed after 4 doses while 3 (7.5%) patients didn’t respond. Oral lesions and pemphigus vulgaris took more time for achieving CR.Conclusion: While we reinforce the idea of using more than 3 doses of RTX 500 mg in a view to achieve prolonged remission we promote considering usage of a more cost-effective drug like azathioprine for maintaining remission especially in a poor remote tertiary center in India with limited resources. Immunological assays were not performed limiting the study.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203527
      Issue No: Vol. 6, No. 5 (2020)
  • Care seeking interval - an indirect measure of sexually transmitted
           infections related stigma: a prospective observational study

    • Authors: Syed Iqbal Sikkanthar, Anitha Christy Stephen, Sakthivadivu Shanmugasundaram, Kayalvizhi V. A.
      Pages: 628 - 631
      Abstract: Background: Stigma about STDs (sexually transmitted diseases) may influence an individual’s decision to disclose information about his/her sexual behaviour to health care practitioners as well as to their sex partners. This leads to a continued transmission of sexually transmitted infections (STI) and greater probability of adverse sequelae. Thus, care seeking interval may be regarded as an indirect measure of stigma associated with STI. The aim of this study is to assess healthcare-seeking behaviour of patients and the factors associated with its delay.Methods: This was a cross-sectional study conducted over a period of 1 year in STD OP of Government Stanley medical college, Chennai which included all symptomatic STD Patients who came to OP. The data were collected using a semi-structured questionnaire. The statistical package SPSS (version 16) was used for analysis.Results: The study included 492 males and 517 females who presented with STD related symptoms. Nearly 54% of patients sought care after 7 days of onset of symptoms. In that 52% of patients reported their delay to be due to fear of disclosure about their symptoms, 19% had self treatment, 12% of them expected spontaneous resolution, 8% had lack of awareness about their symptoms and the remaining 9% reported various other causes.Conclusions: Fear of stigmatisation has a positive association with increased care seeking interval in STDs. Addressing concerns about stigma and educating the public about timely heath care could help reduce the complications of STDs among high risk adult population thereby improving the quality of patient’s life.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203745
      Issue No: Vol. 6, No. 5 (2020)
  • A study of intradermal tranexamic acid for treatment in melasma patients

    • Authors: Haritha Samanthula, Manaswitha Koganti, Neethu Chowdary, Aruna Sree Kurapati
      Pages: 632 - 636
      Abstract: Background: Melasma is a common acquired pigmentary dermatosis due to a disorder in the melanogenesis process. Although several treatments are currently used, it remains a great challenge. It was recently reported that intradermal tranexamic acid (TA- plasmin inhibitor) is an effective treatment for melasma. Aims of the study were to assess the efficacy and side-effects of localized microinjection of TA for the treatment of melasma.Methods: A total of 30 patients with melasma, who did not respond to topical therapy were included in the study, after taking informed consent. The severity and extent of pigmentation was assessed by modified melasma area severity index (MASI). Patients were then administered localized microinjections (10 mg/ml) of TA weekly for 6 weeks. The response to treatment was assessed by MASI and clinical photographs at each session and after 3 months of stopping treatment.Results: Among 30 patients significant decrease in the MASI from baseline was observed. 36.6% patients showed >75% improvement, 43.3% showed 50-75% improvement, 6.8% showed 30-49% improvement, and 13.3% showed <30% improvement at the end of 6 weeks. Side effects were minimal, and all the patients tolerated the treatment well. At 12 weeks 32% of patients developed mild recurrences and the rest of the patients maintained the same MASI.Conclusion: Based on our results, intradermal TA (10 mg/ml) can be used as potentially new, effective and safe treatment for melasma.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203746
      Issue No: Vol. 6, No. 5 (2020)
  • Diagnostic dermoscopic features and the correlation between dermoscopic
           and histopathologic features in lichen planus

    • Authors: Sherin Jose, George Kurien
      Pages: 637 - 640
      Abstract: Background: Lichen planus (LP) is an autoimmune dermatosis characterized by pruritic violaceous flat-topped polygonal papules predominantly over the extremities but can also affect trunk, mucosa, scalp, palms, soles and nails. Dermoscopy is a novel non-invasive imaging modality and the presence of salient dermoscopic features will help to obviate the need for skin biopsies in many doubtful cases.Methods: This was a descriptive study of 108 cases of classical lichen planus cases conducted at a tertiary care hospital in South India over a period of one year. Dermoscopic examination of the LP lesions were carried out using DermLite DL3N and histopathological samples were analyzed in 35 cases.Results: The dermoscopic features were blue globules in 100%, Wickham’s striae in 92.6% and comedo like openings in 49.1%. Vascular patterns were noted only in 13%. On correlating Wickham’s striae in dermoscopy with wedge shaped hyper granulosis on histopathology using the chi-square test we found agreement (kappa value 0.242). We also found that dermoscopy was 93.75% sensitive and 33.33% specific regarding Wickham’s striae in relation to wedge shaped hyper granulosis. In 85% of cases blue globules were present dermoscopically and dermal melanophages were found histopathologically.Conclusions: Wickham’s striae can be considered as a diagnostic dermoscopic finding in lichen planus whereas findings like bluish pigmentation and vascular structures depended on the skin colour of the patient. We also found agreement between dermoscopic and histopathologic features namely Wickham’s striae with wedge shaped hyper granulosis and blue globules with dermal melanophages.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203747
      Issue No: Vol. 6, No. 5 (2020)
  • Clinico-investigation on epidemiological study in 119 Indian cases of

    • Authors: Rashi Pangti, Vibhu Mendiratta, Ram Chander, Meenu Malik
      Pages: 641 - 647
      Abstract: Background: Melasma, a multifactorial disease, constitutes the most common facial melanosis in Indian population.Methods: 119 cases of melasma aged 18 years or above were enrolled. Detailed history, examination and laboratory investigations were done.Results: 20 (16.8%) were males and 99 (83.2%) females. Mean age was 35.25 years. Disease duration was more than 1 year in 102 (85.7%), 6 months to 1 year in 10 (8.4%) and less than 6 months in 7 (5.9%). 22 (18.49%) had occupation-related increased duration of sun-exposure 19 (86.3%) or heat-exposure 3 (13.6%). 79 (66.4%) had skin type IV, 26 (21.8%) type III, 14 (11.8%) type V. Centrofacial was commonest distribution pattern in 87 (73.1%), malar in 30 (25.2%), mandibular in 2 (1.7%). Mean duration of daily sun-exposure was 53.36 minutes (male-124.75, female-38.94). Mean Melasma Area and Severity Index (MASI) score was 11.602. There was significant association between MASI and skin type (p<0.001). Other etiological factors were: Oral Contraceptive Pills (OCPs) use in 17 (17.17%), melasma during pregnancy in 39 (39.4%), family history of melasma in 24 (20.2%), hair dye use in 66 (55.5%), cosmetics use in 19 (16%), mustard oil use in 31 (26.1%), mustard oil along with other oil(s)’ use in 39 (32.8%). Laboratory investigations revealed anemia in 60 (50.42%), dyslipidemia in 73 (61.34%), abnormal thyroid function test in 26 (21.85%), serum vitamin B12 deficiency in 35 (29.4%) and vitamin D deficiency in 94 (79%).Conclusions: Higher skin phototypes should be cautious about general measures and associated risk factors (hair dye/oils, cosmetics). Increased daily sun-exposure, OCPs use, pregnancy, thyroid disorders are risk factors. Housewives and indoor occupations should be advised physical sunscreens for protection against infra-red radiation. Anemia, dyslipidemia, thyroid dysfunction, vitamin D and B12 levels can be assessed although their exact role in perpetuating/precipitating melasma needs further studies
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203748
      Issue No: Vol. 6, No. 5 (2020)
  • A study on safety and efficacy of intralesional vitamin D3 in cutaneous

    • Authors: Amruthavalli Potlapati, Narendra Gangaiah, Neethu Mary George
      Pages: 648 - 651
      Abstract: Background: Immunotherapy is an upcoming treatment modality for cutaneous warts. Majority of the treatment modalities used for warts are destructive and can be painful, causes scarring and are not suitable for multiple warts. Immunotherapy overcome these shortcomings and it has shown good response both in injected and distant warts. Literature shows only very limited data on the use of immunotherapy, especially vitamin D3, in case of cutaneous warts. Objective was to evaluate the safety and efficacy of intralesional vitamin D3 in cutaneous warts and to assess the treatment response and adverse effects of the same.Methods: Sixty patients of age more than 18 years of both sexes with cutaneous warts were given intralesional vitamin D3 of maximum five doses two weeks apart after obtaining an informed written consent. Patients were monitored for reduction in size and number of warts and also for any side effects.Results: Out of the total 60 patients, 46 (76.6%) patients had complete resolution of warts following injection, 12 (20%) cases showed partial response and 2 (3.4%) cases had no response.Conclusions: Intralesional vitamin D3 was found to be an effective treatment modality for multiple and recalcitrant warts.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203749
      Issue No: Vol. 6, No. 5 (2020)
  • A cross sectional study to investigate the prevalence of metabolic
           syndrome in clinically diagnosed patients of psoriasis vulgaris in South

    • Authors: Pankti Manit Gundavda, Priyanka Chandrakant Patil, Dipak D. Umrigar
      Pages: 652 - 657
      Abstract: Background: Psoriasis is a common, chronic, inflammatory keratinization disorder of the skin. It can be triggered by many environmental as well as genetic factors.  The metabolic syndrome (syndrome X, insulin resistance syndrome) consists of a constellation of metabolic abnormalities that confer increased risk of cardiovascular disease (CVD) and diabetes mellitus (DM). Often coexistence is noticed between psoriasis and metabolic syndrome.Methods: A cross-sectional study was conducted in the Government medical college and new civil hospital, Surat. A total of 115 clinically diagnosed cases of psoriasis vulgaris and similar age and sex matched controls visiting dermatology out patients’ department of new civil hospital, Surat were selected for the study.Results: Prevalence of metabolic syndrome is significantly higher in psoriatic patients after the age of 40 years, and it directly correlates to psoriasis duration. No association observed with gender, percentage of body surface area involved and smoking, but in patients of 18-40 years with metabolic syndrome had significantly higher percentage of body surface area involved as compared to >40 years age group.Patients with metabolic syndrome had mean disease duration of 5.52±5.83 years and BMI was 27.48±4.36.Conclusions: Higher prevalence of metabolic syndrome in patients with psoriasis could play a relevant role in accelerating atherosclerosis. All patients with psoriasis should be encouraged to aggressively correct their modifiable cardiovascular risk factors.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203750
      Issue No: Vol. 6, No. 5 (2020)
  • Leprosy reactions: a prospective study at tertiary care hospital of South

    • Authors: Krunal Tralsawala, Dipak Umrigar
      Pages: 658 - 664
      Abstract: Background: Clinical diagnosis of early leprosy lesions is important as it is one of the leading causes of physical disabilities which cause social stigma leading to discrimination & isolation. Its diagnosis is based upon detailed cutaneous examination along with peripheral nerves. The objectives were to study associations between reaction types with type of leprosy and various deformities and disabilities relating to treatment for leprosy.Methods: This is a hospital-based prospective, cross-sectional observational study. 110 clinically diagnosed Leprosy patients with reactions visiting Dermatology OPD were analysed after obtaining informed consent. Participants’ data were collected for demographic criteria, clinical history, past medical history and family history. Clinical examination of a study participant was performed. Collected data was entered in Microsoft excel worksheet and analysed for frequency distribution. Results: All subjects were in a mean age of 38.03±14.37 years.13.64% patients had positive family history of leprosy. 59 (53.64%) and 51 (46.36%) cases were of type 1 and type 2 reactions, respectively. Out of 59 patients with type 1 reaction, the most common presenting symptom was inflammation of pre-existing lesion observed in 35 (59.32%) cases while the most common presenting symptom of type 2 reactions was erythema nodosum leprosum seen in 34 (66.67%) cases. Type 1 reaction presented histopathologically as upgrading (67.80%) and downgrading reactions (5.08%). Histopathological finding in type 2 reaction were neutrophillic infiltration with macrophage granuloma seen in 54.90% cases.Conclusion: It is important to identify reactions associated with leprosy and its treatment as they can significantly alter the morbidity of an affected individual.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203751
      Issue No: Vol. 6, No. 5 (2020)
  • A study of clinical patterns of cutaneous manifestations among hotel
           workers in costal Karnataka

    • Authors: Pradyumna R. Bhandary, Sanath P. K., Sowmya Kothamasu, Supreetha S. Shetty, Pradeep Senapathi
      Pages: 665 - 669
      Abstract: Background: Catering personnel and other workers exposed to foods may develop both type I and type IV allergic contact dermatitis to foods including spices. Cutaneous manifestations vary according to the place that a worker is employed. Studies on the cutaneous manifestations among restaurant and dhaba workers in India are scarce. This study was conducted to determine clinical patterns of cutaneous manifestations among hotel workers in costal Karnataka. Methods: The present cross-sectional study was carried out among workers of hotels situated in costal Karnataka. Study was conducted through Department of Dermatology, A. J. Institute of Medical Sciences, Mangalore. Consecutive type of non-probability sampling was used for selection of study subjects. A total of 1083 hotel workers from 53 randomly selected hotels, fulfilling eligibility criteria, were included in the study. Results: The prevalence of dermatological manifestations was observed as 34.2% (370/1083) in hotel workers. Prevalence of fungal and bacterial infections was 51.4% and 17.6% respectively. Scabies was found in 6.8% subjects while oral manifestation and nail changes were observed in 3.8% and 2.2% subjects. Conclusion: High prevalence of dermatological manifestations was present in hotel workers especially infective skin conditions like Tinea cruris and scabies. This is important, as they can be a potential source for spread of the infection. There is lot of scope for improving the standards of personal hygiene of hotel workers. Owners of establishments should be made aware of importance of pre-placement and periodical medical examination in order to protect the health of consumer.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203752
      Issue No: Vol. 6, No. 5 (2020)
  • Marginal acrokeratoderma: a case series

    • Authors: Perpetua U. Ibekwe, Adebola O. Ogunbiyi
      Pages: 670 - 675
      Abstract: Marginal acrokeratoderma (MAK) are complex disorders characterized by distribution of cornified papules/plaques along the dorso-plantar and dorso-palmar junction of the feet and hands. They belong to the family of punctate palmoplantar keratoderma. No associated gene defect has been detected. There are two clinically identical types of hereditary/familial MAK; namely acrokeratoelastoidosis (AKE) and focal acral hyperkeratosis (FAH); differentiated by the presence of elastorrehexis in AKE. The aim of this article is to report MPK lesions that are not included in the familiar groupings of punctate and polygonal papules. We described thirteen cases and reviewed the literature. Average age at presentation was 24 years, age ranged from 5 to 79 years. Majority of our cases had lesions on only their feet, that of FAH had lesions on only their hands and AKE had lesions on both hands and feet. Although most lesions reported in literature with FAH and AKE were characterized as 2-5mm flesh-colored to yellowish flat-topped/polygonal, keratotic/punctate papules, coalescing into plaques, we also reported lesions that were keratotic with cracks, desquamating and cobble-stone in appearance. This case series calls for more studies on variations in clinical presentation of MAK lesions and an opportunity to revisit the genetic basis and investigate triggers of this rare disorder.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203753
      Issue No: Vol. 6, No. 5 (2020)
  • Disseminated talaromycosis: an AIDS defining fungal infection

    • Authors: Bijayanti Devi, Sana S., Bharath Meka, Bhuvanesh Raj
      Pages: 676 - 679
      Abstract: Talaromycosis is a systemic mycosis caused by Talaromyces marneffi. It mostly occurs as an opportunistic infection in patients with human immunodeficiency virus (HIV). In India, its endemic in Manipur. We report 3 cases of disseminated talaromycosis with skin eruptions in HIV sero-positive patients from Manipur.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203754
      Issue No: Vol. 6, No. 5 (2020)
  • Familial diffuse comedones, different entity or variant of familial
           dyskeratotic comedones: a case report

    • Authors: Nandakishore Thokchom, Linda Kongbam, Nandita Bhattacharjee, Erika Salam
      Pages: 680 - 682
      Abstract: Familial dyskeratotic comedones(FDC) is a rare autosomal dominant genodermatosis characterized by numerous comedones with dyskeratosis in histology. We report a case of 43-year-old woman and her 16-year-old daughter presenting with extensive diffuse comedones on the face, trunk and proximal extremities. Mild slate-grey pigmentation of face in the mother was an additional finding. Skin biopsy showed crateriform invagination with parakeratotic lamellae filled with keratinous material in the epidermis but no dyskeratosis or acantholysis. The case resembles FDC as described earlier. However, certain features like presence of hyperpigmentation and minimal hyperkeratotic papules, and absence of dyskeratosis or acantholysis may suggest that diffuse familial comedones exist as a different genodermatosis.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203755
      Issue No: Vol. 6, No. 5 (2020)
  • A middle-aged male with bullous lesions and co-morbidities

    • Authors: Lavina Mittal, Suparna Madivalara Yallappa, Praveen Kumar Shanmugam Reddy
      Pages: 683 - 687
      Abstract: Epidermolysis bullosa acquisita (EBA) is a rare acquired type of mechano bullous disease affecting the dermal-epidermal junction (DEJ) of trauma prone acral surfaces. It manifests as tense vesicles, bullae, and milia and typically heals as atrophic hypo or hyperpigmented scars. Classic noninflammatory mechano bullous EBA typically presents at a mean age of 48 years. A 57 years old male patient, presented with itchy fluid filled lesions over the face since, 2 months. On cutaneous examination, discrete and grouped papulo-vesicles on an erythematous base and areas of erosions present over both eyelids, erythematous annular plaque with vesicles at the border present over the left cheek. Blood investigations revealed an increased total blood count, total bilirubin, direct bilirubin, and positive HCV antibodies. Histopathology showed a sub-epidermal blister and surrounding dermis shows inflammatory infiltrate composed of eosinophils and neutrophils. Direct immunofluorescence revealed linear deposits of IgG and C3 at the DEJ. The patient was started on dapsone.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203533
      Issue No: Vol. 6, No. 5 (2020)
  • Unusual microscopic appearance of Sarcoptes scabiei from skin scrapping
           sample and its epidemiology

    • Authors: Forman E. Siagian, Ronny ., Urip Susiantoro, Syahfori Widiyani, Hana C. Yulia, Sisirawaty .
      Pages: 688 - 692
      Abstract: Scabies is still a global parasitic problem with an iceberg phenomenon. Vulnerable people including those with comorbidities and live in close contact to each other in a long time. Its causative agent is Sarcoptes scabiei, an Arthropod which live in the host by burrowing and making tunnel in the skin. The patient usually complaint suffer from nocturnal itching, beside the skin derangement of the affected areas. Here we reported an unusual appearance of S. scabiei from a skin scrapping sample sent to the laboratory of parasitology, Faculty of Medicine, Universitas Kristen Indonesia, Jakarta Indonesia and also discuss its epidemiology.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203520
      Issue No: Vol. 6, No. 5 (2020)
  • Early onset chilblain lupus erythematosus with atypical presentation in an
           Indian girl

    • Authors: Neerja Puri, Anjugam Alagappan, Balvinder Kaur Brar
      Pages: 693 - 695
      Abstract: Chilblain lupus erythematosus (Chilblain LE) is a rare form of lupus erythematosus with only 70 cases reported worldwide with most of the patients in middle age and very few cases in adolescent age group. Herein, we are reporting a 16 years old girl presented with an early age of onset at 10 years with atypical presentation who fulfilled Mayo clinic diagnostic criteria for Chilblain LE.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203756
      Issue No: Vol. 6, No. 5 (2020)
  • Dermatosis neglecta: a case report

    • Authors: Yogesh Devaraj, Ranga Swaroop Mukunda, Mouryabha Shale, Nikitha Reddy Mittamedi, Priyanka Yogananda Yadav, Premika Meenakshi Sundaram
      Pages: 696 - 698
      Abstract: Dermatosis neglecta or dermatitis neglecta is a condition which occurs due to inadequate cleansing of a localised area of skin resulting in the accumulation of dirt, sebum, sweat, corneocytes and bacteria. These patients do not clean the area due to various reasons like pain at the site, prior surgery, physical disability, neurological deficit, or psychiatric illness. Vigorous rubbing of the lesion with alcohol soaked gauze results in removal of the lesion. We report a case of dermatosis neglecta in a 50 year old lady with carcinoma breast following mastectomy on the right side. She did not clean the area adequately as she was scared that the area of suture after mastectomy would give way, thus resulting in hyperkeratotic lesions.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203757
      Issue No: Vol. 6, No. 5 (2020)
  • Novel treatment modality in a case of resistant erythromelalgia

    • Authors: Vidya D. Kharkar, Agni K. Bose, Pandharinath K. Khade
      Pages: 699 - 701
      Abstract: Erythromelalgia presents with redness, pain and warmth of the extremities, which is exacerbated by warming and relieved by cooling. Treatment of pain in erythromelalgia can be difficult, and often polypharmacy is utilized. No single therapy has been found to provide complete relief for any patient. Therefore, a multidisciplinary approach is required to treat pain and its significant negative impact across many domains of functioning. A 21 year old male diagnosed case of primary erythromelalgia since 5 years, presented multiple times with recurrent pain and erythema in bilateral lower limbs. Patient was treated initially with oral antibiotics, tramadol and prednisolone, without relief. Aspirin, amitriptyline, pregabalin, carbamazepine, atenolol were later added which gave him partial relief. Epidural caudal catheter with daily infusion of anesthesia was added along with topical buprenorphine patch when conservative polypharmacy failed to provide complete relief and later unilateral lumbar sympathectomy was done as a last resort. Adding pentoxifylline and compression therapy improved the patient’s condition drastically and complete remission is in progress. The patient required a multidisciplinary approach for pain management and surgical intervention was required due to his refractory nature. However, this also does not give complete relief and thus a combination of both medical and surgical methods is required for best control of symptoms.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203758
      Issue No: Vol. 6, No. 5 (2020)
  • Clouston’s syndrome: a rare case report

    • Authors: Siddalingappa Karjigi, G. Aishwarya Reddy, Kallappa C. Herakal, Vedasree Reddy
      Pages: 702 - 704
      Abstract: Ectodermal dysplasias are a heterogeneous group of disorders with primary defect in hair, teeth, nail and sweat glands with an estimated frequency of about seven per 10,000 births. Numerous types have been described and several classifications exist. Clouston’s syndrome (hidrotic ectodermal dysplasia) is a rare genodermatoses, characterized by a triad of nail dystrophy, alopecia and palmoplantar hyperkeratosis. Clouston’s syndrome is transmitted as an autosomal dominant trait and caused by mutations in the GJB6 gene (13q12), encoding the gap junction protein connexin 30 (CX30). At present, there is no treatment for the disease and management is purely supportive. The improved prognosis over time is likely due to greater recognition of the condition. In this report, a 23-year-old male patient with nail abnormalities and thickening of palmoplantar skin is reported. Anodontia of permanent dentition was present along with androgenic alopecia.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203759
      Issue No: Vol. 6, No. 5 (2020)
  • Paraneoplastic dermatomyositis: a case report from North-East India

    • Authors: Nandakishore Thokchom, Nandita Bhattacharjee, Linda Kongbam, Erika Salam
      Pages: 705 - 707
      Abstract: Dermatomyositis is a rare autoimmune myopathy with distinctive cutaneous changes. It has been associated with a wide range of malignancies like carcinoma ovary, lung, breast, gastrointestinal tract and non-Hodgkin’s lymphoma. The malignancy can be concurrent or can occur before or after the onset of myositis. We report a case of dermatomyositis in a 63-year-old Indian male with nasopharyngeal carcinoma. The characteristic cutaneous features and muscle weakness developed concomitantly with the onset of nasopharyngeal carcinoma.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203760
      Issue No: Vol. 6, No. 5 (2020)
  • Contemporary pursuits of vinegar from scullery to dermatology

    • Authors: Mansi Bansal, Umesh Budhiraja, Himanshu Bansal
      Pages: 708 - 714
      Abstract: Vinegar is widely available as a food ingredient for flavouring and as a preservative. It is one of the oldest skin remedy known to mankind. However, its status in treatment regimens has declined over the decades. This article is an attempt to highlight its therapeutic armamentarium in dermatology, venereology and leprosy. Acetic acid in vinegar has antibacterial, antifungal and antiviral properties. This review talks about various studies of acetic acid for various indications, such as screening for cervical cancer, healing of chronic wounds, atopic dermatitis, onychomycosis, marine dermatoses, acne vulgaris, warts, in sclerotherapy and many others dermatoses.  Combination therapies and newer indications are also described in this article. Recently, its antiviral action in vitro has been demonstrated against the ongoing coronavirus disease of 2019 (COVID-19) pandemic.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203539
      Issue No: Vol. 6, No. 5 (2020)
  • A review on drug induced skin disorders: pathophysiology and therapeutics

    • Authors: Priyanka N., R. Srinivasan
      Pages: 715 - 722
      Abstract: Drugs are the central part of treatment of various disorders. The consequence of drug use may be either positive outcomes (clinical effect of the drug) or negative outcomes (adverse drug events). That is, it contains both risk and benefit. In recent years multiple disorders treated with many drugs by monotherapy or by fixed-dose therapy existing in the market which leads to increased drug-related problems one among that is drug-induced disorders. Morbidity and mortality have increased due to drug-induced disorders. This study was aimed to describe the various drugs induces skin disorders, its pathophysiology, diagnosis and treatment approach. We completed a review of the current evidence for various drug-induced skin disorders its causative drugs and therapeutic intervention of drug-induced skin disorders. A review through Medline, Embase, Pubmed, Wiley online library and selected studies related to drug-induced skin disorders. This is the comprehensive review of drug- induced skin disorders, designed to address prospectively its etiopathogenesis and clinical management. Penicillin, sulfa, phenyl-butazone, Tetracycline are the most common drug induces various skin disorders. There is not much significant differences in the clinical, histopathological or immuno-pathological features between various skin disorders and drug induced skin disorders. Hence knowing the etiopathology, and differential diagnosis is important to a proper treatment approach.
      PubDate: 2020-08-26
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20203761
      Issue No: Vol. 6, No. 5 (2020)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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