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International Journal of Research in Dermatology
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2455-4529
Published by Medip Academy Homepage  [12 journals]
  • Clinical evaluation of pathological dermatoses induced in pregnancy

    • Authors: Anshul Choudhary, Kshitij Saxena, Venket Rao Koti, Amir Shahid Ansari, Shivani Yadav, Titiksha Hans
      Pages: 132 - 137
      Abstract: Background: Pregnancy can present with various dermatoses which is divided into physiological and pathological dermatoses. These dermatoses have various effects on pregnancy and patient’s life. The objective was to study the various pathological dermatoses.Methods: A total of 1425 pregnant females attending dermatology, obstetrics and gynaecology Out Patient Department of Era’s Lucknow Medical College and Hospital were included, out of this 275 presented with pathological dermatoses. Detailed history, examination and investigations were done. Data was analysed using Statistical Package for Social Sciences version 21.0 (test).Results: Pathological dermatoses was seen in 275 pregnant females ranged between 18 to 45 years. Infections or infestations and STDs (53.5%) were the most common dermatological conditions followed by pregnancy specific dermatoses (24.7%), acne and folliculitis (7.6%), non-specific itching (5.8%) and other conditions (10.9%).Conclusions: Pregnant females suffer from number of pregnancy dermatoses. A knowledge of the profile of dermatoses during pregnancy is essential to plan preventive measures, care of the mother and the child.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200506
      Issue No: Vol. 6, No. 2 (2020)
  • Analysis of risk factors behind keloid

    • Authors: Anbumalar Manoharan, Sowmya Manasa Rao
      Pages: 138 - 141
      Abstract: Background: Keloids are firm, thickened, bosselated tumors with fibrous tissue which expands beyond the original injury with common sites being presternum, shoulder, ear lobes. They are more common in Blacks and Hispanics than Caucasians. As there is paucity of studies from South India, this study is done to identify the epidemiological features and analyse the risk factors involved in keloid formation and compare it with previous studies.Methods: 60 subjects were included in the study. Keloid was diagnosed clinically and factors such as the age at presentation, gender, site, size, duration, number and predisposing factors to keloid formation were assessed among them for a period of 18 months.Results: Most of the patients were in the age group of 20-40 years and maximum were females. Majority of patients around 51.67% were affected in chest followed by shoulder (20%). In our study 61.67% patients had keloids of size ≤5 cm and 23 (38.33%) patients had size >5 cm. Most of the patients (41.67%) had keloids of <2 years duration. Maximum number of the patients (68%) had single keloid. 50% of the patients had keloids which occurred after trauma followed by acne (15%), surgery (10%) and herpes zoster (10%), burns (5%). 10% of the patients had spontaneous onset of keloids.Conclusions: The epidemiological features found in this study were similar to the studies conducted in the different parts of the world. Elimination of exacerbating factors will prevent further keloid formation thereby playing a crucial role in the management. 
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200011
      Issue No: Vol. 6, No. 2 (2020)
  • Crocin ameliorated skin tissue inflammation in atopic dermatitis in mice

    • Authors: Abdullah Alyoussef
      Pages: 142 - 146
      Abstract: Background: Atopic dermatitis (AD) is considered a chronic recurrent inflammatory skin disease. In addition, crocin is the major carotenoid compound found in Gardenia jasminoides. It is previously proved to produce anti-inflammatory actions. Therefore, we conducted this research to investigate the therapeutic effects of crocin on a mice model of AD.Methods: Mice were investigated for the number of scratches and dermatitis score. Skin was isolated and used for measurements of gene and protein expression of β-catenin, NFκB, TNF-α and IL-1β.Results:
      Authors found that crocin significantly reduced the number of scratches, ear thickness and dermatitis score. In addition, crocin ameliorated AD-induced elevation in the expression of β-catenin, NFκB, TNF-α and IL-1β.Conclusions: Crocin ameliorated DNCB-induced AD in mice via blockage of β-catenin with subsequent reduction in inflammatory pathway. 
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200592
      Issue No: Vol. 6, No. 2 (2020)
  • Role of insulin-like growth factor 1 in pathogenesis of acne vulgaris:
           relation to acne severity and body mass index

    • Authors: Shereen Adel, Talal A. Abd-El-Raheem, Ghada Ezzat, Nermeen M. Ismail
      Pages: 147 - 150
      Abstract: Background: Acne vulgaris is a multifactorial skin disease. A potential role for insulin-like growth factor-1 (IGF-1) has been suggested in the pathogenesis of acne. Several studies have shown that elevated levels of serum IGF-1 correlate with overproduction of sebum and acne. Objective: Measurement of the serum level of IGF-1 in acne patients in comparison to normal controls and evaluating the relationship of these levels to severity of acne and body mass index (BMI), in order to investigate the role of this factor in the pathogenesis of acne.Methods: Fifty-four patients with acne vulagaris and 42 healthy controls were included. History taking, dermatological examination, clinical assessments of acne severity, calculation of BMI were performed for patients. Blood samples were collected from all participants for estimation of serum IGF-1 level using enzyme linked immunosorbant assay.Results: There was a significantly higher serum IGF-1 level in acne patients (p<0.05) than controls.
      Authors didn’t find a relation of significance between elevated serum IGF-1 level and degree of acne severity and BMI (p>0.05). There was a significant positive correlation between serum IGF-1 level and age of the patients.Conclusions: There is a significantly higher serum IGF-1 in acne patients than controls not related to acne severity and BMI. That is adding to the scientific evidence of IGF-1 role in pathogenesis of acne vulgaris.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200593
      Issue No: Vol. 6, No. 2 (2020)
  • Clinical, epidemiological and autoimmune associations in childhood
           vitiligo in Qatar

    • Authors: Haya Al Mannai, Mohamed Allam, Hassan Riad
      Pages: 151 - 155
      Abstract: Background: Childhood vitiligo although clinically similar to adult onset vitiligo but it has distinct clinical, epidemiological and prognostic features compared to adult onset vitiligo.Methods: This is a retrospective study that was carried out on 85 pediatric patients up to age of 18 years old with the diagnosis of vitiligo, where the clinical and epidemiological data  including clinical type of vitiligo, family history of autoimmune diseases like thyroid disorders and diabetes mellitus and laboratory results including anti-thyroid peroxidase antibodies (anti-TPO antibodies), anti-parietal cell antibodies, antinuclear antibodies (ANA), Vitamin D and Vitamin B12 were retrieved from the files of these patients.Results: The mean age of the children affected by vitiligo was 10.4 years, the mean age of onset of vitiligo was 5.4 years, 54 (63.5%) percent were girls and 31 (36.5%) were boys. A positive family history of vitiligo was found in 44.7% of the participants, family history of DM was found in 64.7% of patients and family history of thyroid disease was found in 32.9% of the participants. The prevalence of thyroid autoimmunity was found to be in 22.4% of total participants.Conclusions: Childhood vitiligo has distinct clinical features, more common family history for autoimmune diseases and thyroid autoantibodies rather than overt clinical diseases, which raise the necessity to perform a routine initial immunological and thyroid screening in children with vitiligo and to repeat them at annual bases if there were abnormal values at base line or strong family history.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200594
      Issue No: Vol. 6, No. 2 (2020)
  • Clinical profile and deformities in leprosy patients: a record based study

    • Authors: Anita Sanker, Sandhya George, Sindhu Chunangat Bhaskaramenon
      Pages: 156 - 160
      Abstract: Background: Leprosy is a chronic disease caused by Mycobacterium leprae, infectious in some cases, and affecting the peripheral nervous system, skin and certain other tissues. Even though leprosy was declared eliminated as a public health problem in India on December 2005, new cases of leprosy continue to appear. Hence a study on clinical profile and deformities in all leprosy cases registered in the last 5 years was done to know the current status of leprosy in this area.Methods: This was a retrospective record-based study of leprosy cases done at Government Medical College, Manjeri, for a period of 5 years from October 2014 to September 2019.Results: 42 cases from the record were included in the study. Maximum cases belonged to the age group of 31 to 40 and males were more than females. 81% of the patients were multibacillary leprosy (MB) and 8 cases belonged to paucibacillary (PB) leprosy. Four child cases were registered as PB cases. Mostly encountered clinical diagnosis was borderline tuberculoid leprosy (23 out of 42) and two had type 1 reaction. Seven patients had deformity of which two had grade 2 deformity and rest had grade 1 deformity.Conclusions: One patient who presented with grade 2 deformity and type 1 reaction was from tribal area indicating low awareness about leprosy among them. More number of cases in the multibacillary group and presence of child cases and deformities reinforces the need for strict surveillance to eradicate leprosy. 
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200515
      Issue No: Vol. 6, No. 2 (2020)
  • Nerve conduction study: can it diagnose leprosy early'

    • Authors: Karthik Sunki, Bramhini B. Koneti, Navya Sreerangapuri, Yerrabelli Mounika, Padmaja Pinjala, J. V. D. S. Prasad
      Pages: 161 - 166
      Abstract: Background: Leprosy is a chronic infectious disease which predominantly involves skin and peripheral nerves. Most important consequences of leprosy are due to the involvement of peripheral nerves which leads to gross deformities and disabilities. Detection of preclinical nerve function impairment can help in the prevention of deformities and disabilities. The objective of the study was role of nerve conduction study (NCS) to detect nerve function impairment (NFI) in leprosy.Methods: An electrophysiological study was conducted for 50 newly diagnosed cases of leprosy from December 2017 to July 2019 at Department of Dermatology, Osmania Medical College, Hyderabad. Nerve conduction velocities, amplitude, and latencies of ulnar, median, common peroneal, posterior tibial, sural nerves are measured.Results: 10 nerves in each patient with a total of 500 nerves were studied by NCS. Only 8 (16%) cases had totally normal NCS. And rest 42 (84%) cases have abnormal NCS. Most common pattern observed is sensory motor axonal neuropathy. A total of 268 (53.6%) nerves were normal before starting multidrug therapy and 232 (46.4%) nerves have abnormal NCS. Among these nerves the involvement of Sensory nerves (49%) are more than motor nerves (42%).Conclusions: NCS is a reliable and reproducible test to detect the early NFI. Though it cannot directly diagnose leprosy, it can be used in suspected cases, newly diagnosed cases, and household contacts to detect the NFI early and prevent the complications associated with it. 
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200471
      Issue No: Vol. 6, No. 2 (2020)
  • Efficacy of ultrathin epidermal grafting followed by narrow band
           ultraviolet B therapy for stable vitiligo: a novel therapy

    • Authors: Lakshmi Kamcharla, Sahitya Tadi, Rakesh Darla, Nageswaramma Sidhabathuni
      Pages: 167 - 173
      Abstract: Background: Different surgical techniques in the form of tissue or cellular grafting procedures are used alone or in combination with narrow band ultraviolet B (NBUVB) to treat stable vitiligo resistant to medical treatment. The aim of the study was to assess the cosmetic results obtained with combination therapy of ultrathin split-thickness skin grafts and adjuvant NBUVB therapy in resistant, stable vitiligo.Methods: Forty patients of stable vitiligo were treated with ultrathin split-thickness grafting and the patients were then put on NBUVB therapy. Extent of repigmentation and final cosmetic outcome at the recipient as well as donor sites were assessed.Results: The initial evidence of repigmentation was noted in the second week after starting NBUVB. Results showed 85% of patients had more than 90% repigmentation and the overall cosmetic results at the recipient site was good to excellent in 90% patients at the end of NBUVB treatment. Perigraft halo of depigmentation was seen in five patients (12%) on the recipient site. Hypertrophic scarring was seen in two patients at the donor site.Conclusions: Ultrathin split-thickness skin grafting, when combined with NBUVB therapy, leads to better cosmetic outcome with faster onset of repigmentation in resistant and stable vitiligo.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200550
      Issue No: Vol. 6, No. 2 (2020)
  • Analysis of response of epidermal melasma to 70% glycolic acid peel

    • Authors: Kumaravel Sadagopan, Namratha Chintakula
      Pages: 174 - 177
      Abstract: Background: Melasma is an acquired disorder which presents as light brown to dark muddy brown macules (hypermelanosis) symmetrically and bilaterally on face mainly in areas which are exposed to sun and is seen more commonly among women. Chemical peels are said to be second line of management in melasma among which glycolic acid peel is considered as a gold standard. Aim of present study was to analyse the therapeutic response of epidermal melasma to 70% glycolic acid peel.Methods: 30 subjects were included in the study. Baseline melasma area and severity index (MASI) score of each epidermal melasma patient was recorded and were treated with 70% glycolic acid peel once in 3weeks for 3months and analysed response after 3 months using MASI scores.Results: Peak incidence of melasma was seen between age groups 31-40 years with female to male ratio 9:1, malar pattern being the most common pattern with majority of the patient’s duration of illness >1 year. 30% had positive family history. 26.6% had history of daily sun exposure >1 hour. 63% reduction of MASI score present. Most common side effects were erythema and burning.Conclusions: 70% glycolic acid along with sunscreen showed significant results in the improvement of melasma with 63% reduction in MASI score 12.97±5.15 to 4.69±1.92.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200021
      Issue No: Vol. 6, No. 2 (2020)
  • Sexual risk behaviour and sexually transmitted infections in men who have
           sex with men

    • Authors: Murugan Swamiappan, Manjula Jagannathan, Aysha Abdulla
      Pages: 178 - 182
      Abstract: Background: In India the estimated men who have sex with men (MSM) population is around 352, 000, among that 4.3% are living with HIV. The incidence of sexually transmitted infections (STIs) in MSM is greater than that reported in women and men who have sex with women only. The aim of the study is to determine the trends of sexual behaviour and the pattern of sexually transmitted infections in men who have sex with men.Methods: A retrospective study of the data collected from the clinical records of all MSM, who had attended the STI clinic of Kilpauk Medical College, Chennai, Tamil Nadu, during the three-year study period, from July 2016 to June 2019. Demographic data, sexual risk behaviour, condom usage and STIs, among the MSM, were computed and analyzed.Results: During the study period 489 MSM attended the STI clinic, 51.9% were bisexual and 48.1 % were homosexual. Among them, exclusive penetrative sex in 50.7%, exclusive receptive sex in 15.7% and both in 33.6% were reported. Condom usage was consistent in 18.8%, inconsistent in 28.8% and 52.9% never used condom. Unprotected sex is more common in oral sex than with anal sex. STIs were seen in 20.9% and HIV in 1.4% of MSM. Syphilis was the most common STI seen.Conclusions: Our study elucidated the high prevalence of STIs among MSM and increasing trends of sexual risk behaviour. Health service providers must take necessary steps to improve the provision of biological and medical measures to screen, treat and prevent infections. 
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200041
      Issue No: Vol. 6, No. 2 (2020)
  • A clinical and epidemiological study of hyperpigmentary disorder of face

    • Authors: Dayanand Raikar, Mohammed Waseem Javed, Anant Arunrao Takalkar
      Pages: 183 - 186
      Abstract: Background: Facial pigmentary disorders are a group of heterogenous entities, sharing a common clinical feature of altered pigmentation of the face and thus easily visible cosmetic disfigurement. Although the increased melanin provides protection from harmful effects of UV radiation, including photodamage and skin cancers, it also makes darkly pigmented skin more vulnerable to post-inflammatory dyspigmentation. The importance of these disorders is growing, as they form the major percentage of dermatology consultations. The objective of the study was to assess the clinical profile of patients with facial hyperpigmentation.Methods: The present cross-sectional hospital based observational study was conducted at Dermatology Department of during the period of June 2017 to December 2017 including patients with diagnosis of facial hyperpigmentation. Data analysed with SPSS 24 version.Results: 29% were from 21 to 30 years age group followed by 25% from 31 to 40 years age group. Mean age of the study population was 28.4±11.8 years. 76% were female patients. Commonly observed facial hyperpigmentation type was melasma in our study i.e. 46%. It is followed by post inflammatory hyperpigmentation (PIH) in 16% and ephilides in 8%. Rehl's melanosis and drug induced melanosis was seen in 7% each of the patients. Ephilides, Rehl's melanosis and drug induced was seen in 7% each of the patients. Family history of pigmentaory disorder was found in melasma, PIH and ephilides in our study.Conclusions: Commonly reported age group was 20-40 with female preponderance. Commonly observed facial hyperpigmentation type was melasma (46%), PIH (16%) and ephilides (8%).
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200207
      Issue No: Vol. 6, No. 2 (2020)
  • Incidence of non-venereal lesions of the male genitalia: a study of 248
           male cases at a tertiary care centre

    • Authors: Mamatha P., Abhijeet Vardhan, Sheena Arora
      Pages: 187 - 192
      Abstract: Background: Non-venereal dermatoses of external genitalia refers to those dermatoses involving external genitalia which are not sexually transmitted. These are associated with mental distress and guilt feelings in affected patients. The aim was to study the incidence of non-venereal lesions of the genitalia.Methods: This was a cross-sectional clinical observational study in 248 male patients attending dermatovenereology OPD of Vydehi Institute of Medical Sciences and Research Center with non-venereal genital lesions for a period of 18 months. Cases having venereal diseases were excluded from the study.Results: The study included 248 male patients with non-venereal genital lesions. A total of twenty-five different types of non-venereal dermatoses were noted in our study. The most common non-venereal dermatoses were Non-venereal infections, seen in 107 patients (43.14%), which includes scabies in 45 patients (18.14%), tinea cruris 25 patients (11.29%), candidiasis 28 (11.29%)  followed by lichen simplex chronicus 23 cases (9.27%) and scrotal dermatitis (6.45%) other dermatoses include psoriasis, lichen planus, fixed drug eruptions, scrotal horn, histoid hansens, squamous cell carcinoma, Zoon’s balanitis.Conclusions: This study reflected the importance of diagnosis of non-Venereal dermatoses and refutes the general misconception that all genital lesions are of venereal origin. 
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200472
      Issue No: Vol. 6, No. 2 (2020)
  • Clinical trends of scalp alopecia areata: a tertiary care hospital based
           observational study

    • Authors: Pallavi Singh, Milind A. Patvekar, Bhavika Shah, Alisha Mittal, Asmita Kapoor
      Pages: 193 - 198
      Abstract: Background: Alopecia areata is one of the commonest types of non-scarring alopecia involving the scalp and/or body. As there is paucity of recent epidemiological data from our country, this study was conducted to determine the latest clinical and epidemiological trends of scalp alopecia areata.Methods: A hospital-based observational study consisting of 100 cases of clinically diagnosed scalp alopecia areata who reported to the Dermatology OPD, Dr. D.Y. Patil Medical College, Pune, was conducted for a period of six months. Socio-demographic and clinical information was collected and clinical examination was performed on all patients. The data was evaluated using appropriate statistical methods.Results: Out of the 100 cases enrolled, males (64%) outnumbered females (36%). The commonest presenting age group was 21-30 years (44%). Disease onset was sudden in 80% patients and 59% cases had a progressive disease course. Majority (75%) had a disease duration of less than 3 months. Majority cases were asymptomatic (80%) with no precipitating factors (90%). Past history and family history of alopecia areata were present in 13% and 9% cases, respectively. Personal and family history of associated diseases were present in 27% and 22% patients, respectively. Most patients had single (61%), patchy (83%) lesions with occiput (45%) being the commonest initial site. Nail changes were present in 22% cases, of which pitting (13%) was the commonest nail finding.Conclusions: This study reflects the clinical profile of scalp alopecia areata in a tertiary care hospital.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200607
      Issue No: Vol. 6, No. 2 (2020)
  • Study of common clinical types of cutaneous tuberculosis: two years study
           experience in a tertiary care centre

    • Authors: Raghu M. T., Ashwini S., Yogendra M., Virupakshappa H. E., Gangaraju Harish, Nikitha Babu
      Pages: 199 - 202
      Abstract: Background: Cutaneous tuberculosis (TB) is frequently found worldwide, especially in tropical countries. The number of extrapulmonary TB reaches up to 14%, and 1% to 2% are cutaneous TB. Diagnosis of cutaneous tuberculosis (CTB) is complicated and requires a full work-up. Clinical manifestation of cutaneous TB is varied and causes difficulties to diagnose. Scrofuloderma and plaque type of lupus vulgaris (LV) are common forms of cutaneous TB.Methods: A retrospective study was conducted on patients attending Department of Dermatology, Venereology and Leprosy, at Basaveshwara Medical College and Hospital, Chitradurga over a period of 2 years. A total of 15 cases of cutaneous tuberculosis were diagnosed.Results: A total of 15 cases out of which included predominantly males, with age group being affected commonly are 20-40 decades, histopathology showing tuberculoid granuloma in 11 cases, and common clinical variant being lupus vulgaris seen in 66.6% of the cases and. Second common being scrufuloderma seen in 26.6% of the cases and least common is TB verrucosa cutis (TBVC) seen in 6.6% of the cases.Conclusions: The study showed that the common clinical type of cutaneous tuberculosis during the study period was lupus vulgaris, scrofuloderma and less common being TBVC.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200596
      Issue No: Vol. 6, No. 2 (2020)
  • Hepatitis C seropositivity in lichen planus: a case control study in a
           tertiary care hospital

    • Authors: Gangaiah Narendra, Mowazaffin Ahmed, Potlapati Amruthavalli, Raghunatha Shivanna
      Pages: 203 - 207
      Abstract: Background: Lichen planus (LP), an immune-mediated disorder, has been reported as an extra-hepatic manifestation of Hepatitis C virus (HCV) infection, especially in HCV hyper endemic areas such as southern Europe and Japan. In India, the association between LP and HCV is documented in many studies. The aim of this study was to investigate hepatitis C virus infection in patients with lichen planus from an epidemiological standpoint and determine the sero-positivity of hepatitis C virus in patients with lichen planus and also to describe clinical profile of lichen planus in patients with hepatitis C virus infection.Methods: This hospital-based case control study was conducted over 167 patients and 167 controls, evaluation included detailed history, cutaneous examination, routine blood tests and ELISA test for seropositivity.Results: In this case control study 5.4% of the total study population presented with hepatitis c infection. Hepatitis C infection was more common in oral LP out of all the HCV positivity obtained in LP patients. Male to female ratio was 1:2.2. Prevalence of HCV infection was found to be slightly more in cases (6.6%) than controls (4.2%) but there is no statistically significant difference in the prevalence of HCV infection among cases and controls.Conclusions: In conclusion, from the evaluation of our epidemiological data, any etiological link between LP and HCV could not be found in our population and an etiological link between LP and HCV cannot be inferred solely by epidemiological data.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200597
      Issue No: Vol. 6, No. 2 (2020)
  • A study on the efficacy of platelet rich plasma for the treatment of
           patterned hair loss

    • Authors: Neerja Puri, Sushma Thakur
      Pages: 208 - 211
      Abstract: Background: Platelet rich plasma (PRP) is a promising and novel therapy new therapy for the treatment of androgenetic alopecia. There are various growth factors in PRP which induce the proliferation of dermal papilla cells.Methods: We selected twenty-five cases of both male and female pattern hair loss for the study.Results: Very good improvement was seen in 8 (32%) patients, good improvement was seen in 12 (48%) patients, average improvement, was seen in 2 (8%) and poor improvement, was seen in 3 (12%) patients. Regarding the side effects of PRP, bruising was seen in 2 (8%), pain was seen in 3 (12%). After 4 months of treatment, average hair count increased by 40% and average hair shaft diameter increased by 56%.Conclusions: PRP is a novel therapy, but is not an evidence-based therapy for the treatment of alopecia.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200604
      Issue No: Vol. 6, No. 2 (2020)
  • Clinical spectrum of facial hypermelanosis: a descriptive study from a
           tertiary care centre

    • Authors: Mohammed Thoyyib, Roshni Menon, Brinda G. David
      Pages: 212 - 217
      Abstract: Background: Facial melanosis (FM) which refers to brown, black or blue pigmentation over the face is a common cosmetic concern in Indian patients. This increased incidence could be due to remarkable diversity of Indian ethinic population. Pigmentary disorders of the face are a great cosmetic and psychological concern for the patients.Methods: This is an extensive descriptive clinico epidemiological study comprising of 1024 patients, conducted at Sri Venkateshwara Medical College Hospital and Research Centre, Puducherry, for a period of one and a half years. A detailed clinical history and examination was done, and all the clinical photographs and data were recorded. Necessary investigations like skin biopsy and patch testing was done wherever required.Results: The maximum number of patients belong to the age group of 21-35 years with a female predominance (67.2%). Among patients of FM, post inflammatory pigmentation (35.3%) was the most common comprising of 362 patients, followed by melasma (17.2%), periorbital melanosis (15.7%), seborrheic melanosis (7.5%) followed by other causes.Conclusions: FM is common in Indian skin, several of which have overlapping features, and some have defined clinical classification. Additionally, climatic conditions, cosmetic usage and social parameters predispose to the increased incidence of FM.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200599
      Issue No: Vol. 6, No. 2 (2020)
  • A study of clinico pathological spectral correlation in multibacillary

    • Authors: Anita Sanker, P. S. Mathew, G. Nandakumar, Sandhya George, V. G. Binesh
      Pages: 218 - 223
      Abstract: Background: Leprosy expresses itself in different clinico-pathological forms, depending on the immune status of the host.The diagnosis and classification of leprosy have traditionally been based on the clinical examination with additional information from skin smears and histopathological examination. Very often, disparities between clinical and histopathological findings are observed. This study was aimed to correlate between clinical and histopathological spectral correlation of newly diagnosed multibacillary leprosy cases for a period of 1 year.Methods: The study was conducted in the Department of Dermatology and Venereology, Government Medical College, Thiruvananthapuram, for a period of 1 year. All newly diagnosed multibacillary leprosy cases were included.Results: A total of 40 patients with clinically diagnosed multi bacillary leprosy were studied. Maximum numbers of leprosy patients studied were in the age group of 40-49 years. Maximum clinical and histopathological correlation was found in 75% (9/12) in lepromatous leprosy and least correlation of 44.44% was noted in borderline lepromatous (4/9).Conclusions: In this study maximal clinico-histopathological spectral correlation was found in lepromatous  spectrum. The percentage of correlation was considerably less in all the other groups.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200600
      Issue No: Vol. 6, No. 2 (2020)
  • Laser for post acne scars with or without growth factors: a comparative
           clinical trial

    • Authors: Lakkireddygari Sujana, Balachandra S. Ankad, Savitha L. Beergouder
      Pages: 224 - 229
      Abstract: Background: Treatment of acne scars presents a considerable challenge to dermatologists. But with advent of fractional CO2 (FCO2) laser and platelet-rich plasma (PRP), new avenues can be explored. PRP provides various growth factors, so that the healing of laser-damaged skin is accelerated. The aim of this study was to assess the efficacy and safety of FCO2 laser alone and in combination with PRP in patients with post-acne scars.Methods: Eighty patients with acne scars were counseled and randomly assigned into two groups of 40 each. Group A was treated with FCO2 laser alone, while Group B was treated with FCO2 laser and PRP for 6 months. Primary objective was assessment of efficacy of both treatment modalities. Secondary objective was evaluation of safety of treatments.Results: At the end of 6 months, group A showed about 18% reduction, while group B showed about 33% reduction in acne scars on objective assessment. Patient satisfaction as assessed by subjective assessment was greater in group B than in group A. Duration of erythema, edema and crusting was lesser in group B compared to group A.Conclusions: Combination of FCO2 and PRP was found to be more efficacious as compared to FCO2 laser alone. Combining the treatment modalities can provide a new strategy for treating the post-acne scars.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200601
      Issue No: Vol. 6, No. 2 (2020)
  • Clinical pattern of papulosquamous dermatoses: an observational study
           conducted at tertiary care center, Ujjain, Madhya Pradesh, India

    • Authors: Krishnendra Varma, Ujjwal Kumar, Varun Kumar
      Pages: 230 - 236
      Abstract: Background: Papulosquamous dermatoses is a complex group of disorder characterized by scaly papules and plaques. There is a need to study the exact, pattern and prevalence of this disorder in different age groups and their line of treatment. Objective of the study was to observe the clinical pattern of various papulosquamous dermatoses and their prevalence at tertiary care center, Ujjain.Methods: This was an observational study done in R.D. Gardi Medical college, Ujjain over a period of one year. A total of 229 cases including male and female of papulosquamous dermatoses were enrolled from the outpatient department. All patients were studied clinically and relevant data was recorded. Microsoft excel was used for data entry and analysis was done using SPSS version 23.Results: There were 139 (60.7%) males and 90(39.3%) females with overall male to female ratio was 1.54:1. Most common age group affected with papulosquamous dermatoses was 31-50 years. The clinical pattern observed was psoriasis 49.3%, lichen planus 24.5% followed by pityriasis rosea 10.5%. The least common papulosquamous diseases were pityriasis rubra pilaris (1.3%) and lichen nitidus (1.3%). Most common variant of psoriasis and lichen planus was chronic plaque and classical respectively. Classical juvenile variant of pityriasis rubra pilaris was seen in our study. A single rare case of lymphomatoid papulosis was noted in our study.Conclusions: Psoriasis, lichen planus and pityriasis rosea were commonest papulosquamous diseases were observed but still we need more longer duration of observational studies on papulosquamous dermatoses to understand the morphological features for the effective management of these diseases.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200602
      Issue No: Vol. 6, No. 2 (2020)
  • Nail changes in various dermatoses: an observational study conducted at
           tertiary care center, Ujjain, Madhya Pradesh, India

    • Authors: Ujjwal Kumar, Krishnendra Varma, Ankur Shayalwar
      Pages: 237 - 242
      Abstract: Background: Nail apparatus forms an integral part to be examined for all dermatological conditions. Nail changes are seen in various dermatosis like psoriasis, onychomycosis, lichen planus, collagen vascular disease, vesicobullous diseases and other papulosquamous diseases. Aims and objective of the study was to determine the prevalence of nail changes in various dermatological conditions.Methods: After applying inclusion and exclusion criteria, 269 cases with various nail changes were enrolled in the study. Detailed history and thorough nail examination was carried out along with other necessary investigations like CBC, RFT, LFT, nail clipping for fungal hyphae culture and microscopy.Results: Out of 269 cases with nail disorders, male to female ratio was 1.5:1 and most common age group was 31-40 years. The most common abnormality observed was onychomycosis (34.2%) followed by nail changes in psoriasis (30.4%), LP (18.5%), eczema (4%), trachonychia (3.3%), paronychia (2.9%), lichen striatus (2.2%) and darier’s disease (0.37%). Among onychomycosis most common pattern observed was DLSO (82.6%) followed by PSO (7.6%), SWO (5.4%) and TDO (4.34%). The pattern of nail changes in psoriasis patients was pitting (30.4%), subungual hyperkeratosis (21.9%) and onycholysis (10.9%). Cases with LP had longitudinal striations (52%), thinning of nail plate and trachonychia (10% each). V shaped notching and distal splitting was seen in one of the Dariers’ disease patient.Conclusions: Nail changes form an indispensible part of various dermatological conditions. The pattern of involvement is unique in each and every disease. Hence examination of all the 20 nails should never be missed.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200603
      Issue No: Vol. 6, No. 2 (2020)
  • A comparative study of fractional carbon dioxide laser, narrowband
           ultraviolet B and topical tacrolimus 0.1% ointment versus narrowband
           ultraviolet B, topical tacrolimus 0.1% ointment in stable vitiligo

    • Authors: Anusha Putta, Mohammed Waseem Javed
      Pages: 243 - 247
      Abstract: Background: Vitiligo, an acquired pigmentary disorder of skin and mucous membrane characterized by well circumscribed depigmented macules that occur secondary to selective destruction of melanocytes. Fractional CO2 laser system is a recent advancement in the treatment of vitiligo which works on the concept of fractional photo-thermolysis, in which microscopic treatment zones are created which help in increasing the penetration of topically applied agent which indirectly improves drug efficacy.Methods: A comparative study was conducted on 40 patients of stable vitiligo attending OPD, Dept of DVL with fractional CO2 laser, narrowband ultraviolet B (NBUVB) and topical tacrolimus 0.1% vs NBUVB, topical tacrolimus 0.1% for a duration of 4 months and patients were followed up for 12 weeks post treatment.Results: Patients on Fractional CO2 laser in combination with NBUVB and topical tacrolimus 0.1% ointment showed >50% improvement compared with other group, with duration for initiation of pigmentation being comparatively less.Conclusions: The treatment protocol with CO2 laser in combination with topical tacrolimus 0.1% cream and NBUVB for stable vitiligo was more effective than NBUVB and topical tacrolimus 0.1% alone and this study demonstrates that adding fractional CO2 laser improves repigmentation rate of vitiliginous lesions.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200605
      Issue No: Vol. 6, No. 2 (2020)
  • Therapeutic efficacy of topical luliconazole versus topical ketoconazole
           in the treatment of pityriasis versicolor patients: a hospital based
           comparative study

    • Authors: Shahid Hassan, Ashutosh Ranjan
      Pages: 248 - 252
      Abstract: Background: To evaluate the clinical efficacy of 1% topical luliconazole versus 2% topical ketoconazole in pityriasis versicolor patients.Methods: Mycological examination of all the pityriasis versicolor patient was done by using skin scrapings were collected from the skin lesions to prepare for 10% KOH mount, which was examined under the microscope to note the findings as KOH mount positive or negative for Malassezia fungi. KOH mount positive or negative was noted at 0 days, 2 weeks and 4 weeks continued treatments with luliconazole and ketoconazole.Results: At the first days, majorities of patients 46 (92%) of luliconazole group were positive for KOH mount. At 14 days treatment with luliconazole, patients had 11 (22%) positive for KOH mount. At the 28 days treatment with luliconazole, only 2 (4%) patients were positive and most of the patients 49 (98%) were negative for KOH mount. Similarly, in ketoconazole group patients, 47 (94%) patients were positive for KOH mount in beginning of treatment. At 14 days treatment with ketoconazole 16 (32%) patients were positive and 34 (68%) patients were negative for KOH mount. And at the 28 days with treatment of ketoconazole 13 (26%) patients were positive and most of the patients 37 (74%) were negative for ketoconazole.Conclusions: Male population as well as age 26-35 years were more prone for pityriasis versicolor infection. On two weeks of treatment luliconazole and ketoconazole had near about similar efficacy against pityriasis versicolor. But, on continue 4 weeks of treatment regimens topical luliconazole had more clinically efficacious than ketoconazole against pityriasis versicolor.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200606
      Issue No: Vol. 6, No. 2 (2020)
  • Congenital cutis laxa with multi-system involvement

    • Authors: Karan Malhotra, Karjigi Siddalingappa, Kallappa C. Herakal
      Pages: 253 - 256
      Abstract: Cutis laxa is a heterogeneous group of inherited and acquired rare connective tissue disease characterized by loose, wrinkled, and inelastic skin. It clinically presents as loose skin with folds giving a premature aged appearance. Cutis laxa is very rare, with an estimated incidence of one in 4 million. There are many case reports on acquired cutis laxa but very few on “congenital” cutis laxa.
      Authors report a 15 years old female presenting with a history of recurrent respiratory tract infections since the age of 2 years associated with flaccid skin all over her body and extensive loose folds of skin over face, neck, abdomen, arms and thighs since birth. Cutis laxa has been diagnosed based on the clinical picture and histopathological appearance. No medical treatment is available for correction of the pathology of disease. Plastic surgery remains the only modality of treatment to improve the cosmetic appearance. Systemic abnormalities need specific treatment depending upon the condition. The purpose of this report is due to its rarity and involvement of skin, hairs, respiratory, cardiovascular and genitourinary system in a single patient.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200598
      Issue No: Vol. 6, No. 2 (2020)
  • Hand and foot syndrome secondary to capecitabine

    • Authors: Murali Narasimhan, Abhishek Kumar, Ramachandran Ramakrishnan
      Pages: 257 - 259
      Abstract: Hand and foot syndrome are an adverse effect often seen with chemotherapy or with the use of biologics. It is characterised by painful erythema and edema, dry or moist desquamation of palms and soles in mild to moderate case. Severe cases usually present with cracking, peeling, blister, ulcer and severe pain. Here we report a 65-year-old woman with breast carcinoma who was on treatment with capecitabine and presented with fissuring and bleeding over palms and soles, with progressive burning sensation. On examination, hyperpigmentation and scaling were also noted over both palms and soles. She was diagnosed with hand and foot syndrome and was treated with emollients, antibiotics and topical steroids.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200595
      Issue No: Vol. 6, No. 2 (2020)
  • Case reports on erosive pustular dermatosis of scalp: a cross sectional
           study at a tertiary care centre

    • Authors: Avanitaben D. Solanki, Neha S. Nagrani, Dhara V. Patel, Neela M. Patel, Jigna P. Barot, Anisha V. Arora, Jahnavi H. Patel
      Pages: 260 - 263
      Abstract: Erosive pustular dermatosis of the scalp (EPDS) has been reported as a rare chronic and progressive non-infectious inflammatory condition of the actinically damaged scalp characterized by crusts, erosions and pustules. It tends to occur on the scalp of older people who have usually been treated for diffuse actinic damage and actinic keratoses. The list of possible differential diagnosis is long and includes tinea capitis, folliculitis decalvans, neutrophilic dermatosis, autoimmune vesiculobullous disorders, malignancy etc. Notoriously difficult to treat, these cases tend to be chronic and progressive. These patients often present after repeated treatment to various scalp dermatosis that doesn’t result in clearing instead persistence and perpetuation of the process. A cross sectional prospective study was conducted in department of dermatology in a tertiary care centre in which six cases of EPDS attending outpatient department from 2017 to 2019 were included. EPDS is more common but under recognized condition, hence less cases are reported till date. Increased awareness of and proper diagnosis of this condition changes the approach towards these patients, protects the scalp from involuntary insults and other precipitating factors that hinders with a better outcome.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200610
      Issue No: Vol. 6, No. 2 (2020)
  • The dreaded osteonecrosis of femur following chronic steroid therapy: a
           case series from a dermatologist’s eye

    • Authors: Abiram Ponnuswami, Cordelia Babitha S., Krishnakanth Muralidhar, Murugan Sundaram
      Pages: 264 - 266
      Abstract: Corticosteroids, undoubtedly, is the saving grace of many patients ailing from a variety of inflammatory and autoimmune dermatoses. But it is not free of side effects, some being crippling enough to subject the patient to huge amounts of morbidity. Here we report a series of cases – Vesiculobullous diseases and Lupus Erythematosus - with prolonged oral steroid therapy that lead to osteopenia and osteonecrosis of the femur.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200609
      Issue No: Vol. 6, No. 2 (2020)
  • Phthiriasis palpebrarum: a diagnosis of keen observation and suspicion

    • Authors: Muthu Bharathi Sivasubramanian, Ramachandran Ramakrishnan, Murali Narasimhan
      Pages: 267 - 268
      Abstract: Phthiriasis palpebrarum is a rare cause of eyelid infestation and it mimics seborrheic blepharitis. A 60 years old female presented with itching in the eyelids and scalp. On initial examination scaling was present in her eyelashes and eyelid margin. On further examination some movements were noticed in her eyelashes. Immediately, dermatoscopic examination was done and was found to have multiple nits and multiple crab lice over her eyelashes. She was treated with oral ivermectin and trimming of eyelashes as advised by ophthalmologist. She improved in a week. Thus, phthiriasis palpebrarum can mimick seborrheic blepharitis and therefore high index of suspicion and detailed examination is necessary for appropriate diagnosis.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200608
      Issue No: Vol. 6, No. 2 (2020)
  • Glomus tumor: an atypical presentation

    • Authors: Rajeshwari K. A., Rajagopal R.
      Pages: 269 - 271
      Abstract: Glomus tumors are rare soft-tissue neoplasms of the neuromyoarterial glomus body, typically present in adults as small, blue-red papules or nodules of the distal extremities, with most cases involving subungual sites. The majority of glomus tumors are benign, malignant cases have been rarely reported, with such cases typically being locally invasive. 27 years old patient presented with four years history of intermittent swelling, pain in left lower leg. Biopsy of the lesion revealed lobulated vascular tumour composed of endothelial cells showing intracytoplasmic lumina and solid aggregates of tumour cells, divided by intervening fibrocollagenous septae. Glomus tumour of uncertain malignant potential was diagnosed after excision biopsy. Multispeciality team approach was done for complete cure of the condition.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200611
      Issue No: Vol. 6, No. 2 (2020)
  • Four sexually transmitted diseases in one: a rare case report

    • Authors: S. D. Fernandes, N. Jegadish, R. Ramachandran, K. Gopalakrishnan, Murali Narasimhan
      Pages: 272 - 274
      Abstract: Sexually transmitted diseases (STDs) often pose a diagnostic challenge especially in countries like India, where access to reliable diagnostic laboratory tests is minimal. The exact cause of the STDs has to be determined, so that appropriate therapy can be administered and the risk of transmission to others can be reduced. However, determining the etiology can be complicated by limitations of current diagnostic testing modalities and by the fact that more than one infection may coexist. Here, authors report a case who presented with genital ulcer disease and discharge with four etiologies.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200612
      Issue No: Vol. 6, No. 2 (2020)
  • The legal aspects faced by cosmetologists and dermatologists

    • Authors: Shobhit Mohan, Lalit Mohan, Renu Sangal, Neelu Singh
      Pages: 275 - 278
      Abstract: The present-day cosmetologists, in addition to conventional skin physicians, are also cosmetologists and minor skin surgeons in their practice. The cosmetic procedures have the risk of legal problems leaving an unsatisfied patient and troublesome law. One should have safe practice of cosmetology and possible complications and how to overcome these complications after cosmetology procedure. Doctor should know the routine precautions which help him to avoid unnecessary calls by the court.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200613
      Issue No: Vol. 6, No. 2 (2020)
  • Dermaroller in dermatology and cosmetology

    • Authors: Shobhit Mohan, Lalit Mohan, Renu Sangal, Neelu Singh
      Pages: 279 - 283
      Abstract: Dermaroller is a novel therapeutic modality in dermatology. Through physical trauma from needle penetration, dermaroller induces a wound healing cascade with mild temporary damage to the epidermis. This allows for the enhancement in the absorption of topical therapies across the thick stratum corneum. Dermaroller has become increasingly utilized over the last several years as it is a relatively simple procedure that is cost effective, well tolerated and offers cosmetic and therapeutic benefits. The ability to treat localized areas of disease made it popular in acne scars, alopecia, striae, melasma, actinic keratoses. The procedure has few adverse sequelae compared to other therapies, is highly effective and a viable resurfacing option for color of skin.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200614
      Issue No: Vol. 6, No. 2 (2020)
  • Glutathione for skin lightening for dermatologists and cosmetologists

    • Authors: Shobhit Mohan, Lalit Mohan, Renu Sangal, Neelu Singh
      Pages: 284 - 287
      Abstract: Glutathione is a potential antioxidant and its reduced form (GSH) has a good skin-whitening effect in humans through its tyrosinase inhibitory activity. Many physicians consider it as a Wonder drug for skin lightening and treatment of hyperpigmentation, especially with darker skin tones. Glutathione is available in topical, oral and injectable formulations. Topical and oral forms are considered to be safe. Intravenous form did not prove its safety and efficacy to till date. In this article, we shall review and discuss the current status of glutathione as a skin lightening agent and address the miscellaneous unanswered queries regarding the dosage, duration of use and longevity of accrued effects based on clinical evidence and recent insights into its antimelanogenic mechanism.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200615
      Issue No: Vol. 6, No. 2 (2020)
  • Platelet rich plasma in dermatology and cosmetology

    • Authors: Shobhit Mohan, Lalit Mohan, Renu Sangal, Neelu Singh
      Pages: 288 - 291
      Abstract: Platelet rich plasma (PRP) therapies in medicine has become increasing popular during the last decade. The interest in in the application of PRP in dermatology and cosmetology has increased recently in different applications such as alopecia, skin rejuvenation, wound healing, scar revision, and tissue regeneration. PRP is an autologous blood product obtained from the blood of the patients. The detailed knowledge about PRP should help clinicians better understand this therapy. In this view, the current review was done for a better understanding of what pathologies can be corrected with PRP.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200616
      Issue No: Vol. 6, No. 2 (2020)
  • Safety of voriconazole in treatment of fungal infections

    • Authors: Shobhit Mohan, Lalit Mohan, Renu Sangal Sangal, Neelu Singh
      Pages: 292 - 294
      Abstract: Immunocompromised patients are at more risk in developing fungal infections particularly with Candida and Aspergillus species being the mycoses most commonly identified. Previously, amphotericin-B is the drug of choice for the treatment of systemic infections caused by Candida and Aspergillus species. Due to its high incidence of toxicity, its use has been limited in many cases. Voriconazole is the newest triazole synthesized against fungal infections and was approved by FDA in 2002 for the treatment of invasive aspergillosis and refractory infections of Scedosporium apiospermum and Fusarium spp.
      PubDate: 2020-02-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20200617
      Issue No: Vol. 6, No. 2 (2020)
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