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Publisher: Medip Academy   (Total: 12 journals)   [Sort by number of followers]

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Intl. J. of Advances in Medicine     Open Access   (Followers: 2)
Intl. J. of Basic & Clinical Pharmacology     Open Access   (Followers: 3)
Intl. J. of Clinical Trials     Open Access   (Followers: 2)
Intl. J. of Community Medicine and Public Health     Open Access   (Followers: 5)
Intl. J. of Contemporary Pediatrics     Open Access   (Followers: 4)
Intl. J. of Otorhinolaryngology and Head and Neck Surgery     Open Access  
Intl. J. of Reproduction, Contraception, Obstetrics and Gynecology     Open Access   (Followers: 11)
Intl. J. of Research in Dermatology     Open Access   (Followers: 1)
Intl. J. of Research in Medical Sciences     Open Access   (Followers: 5)
Intl. J. of Research in Orthopaedics     Open Access  
Intl. J. of Scientific Reports     Open Access   (Followers: 2)
Intl. Surgery J.     Open Access   (Followers: 1)
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International Journal of Research in Dermatology
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2455-4529
Published by Medip Academy Homepage  [12 journals]
  • An epidemiological study of allergic contact dermatitis in Greece:
           prevalence of sensitization to an adapted European baseline series’

    • Authors: Anna Tagka, Alexandros Stratigos, Panagiotis Stavropoulos, Dimitrios Rigopoulos, Argiro Chatziioannou
      Pages: 460 - 470
      Abstract: Background: Contact dermatitis is a common skin disorder related to environmental exposures affecting, all age groups, and both genders. The pattern of contact sensitization to a series of allergens included in the European baseline series has already been studied for a number of EU countries by the ESSCA Network. The current study aims to explore the patterns of contact dermatitis in Greece through a patch test against a large number of allergens provoking contact dermatitis.Methods: Retrospective analyses of routine data of 668 patients were collected during 2014 in the Laboratory of Patch Testing, National Referral Centre of Occupational Dermatoses. Sensitization in all cases was tested with a battery of 28 allergens of the European baseline series and additional ones aiming to identify new sensitizations to inform the National baseline of allergens; information for an extended MOAHLFA index was also collected.Results: One at least positive result was found in 61.5% of the patients while 19.1% of those found to be sensitized in two or more allergens. Nickel sulphate, fragrance mix and balsam of Peru were the most prevalent allergens in the total population, as well as with respect to gender. Nickel is the most frequent allergen of baseline series, a result which is in agreement with other reports.Conclusions: Allergic contact dermatitis surveillance is of great importance towards the clinical and systematic understanding of the disease. Further studies should be directed towards that end, in order to facilitate more effective health policies.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20183443
      Issue No: Vol. 4, No. 4 (2018)
  • A randomized, open label, comparative, five-arm, controlled study
           evaluating the benefit and tolerability of oral superoxide dismutase
           combined with gliadin as add-on neutraceutical therapy with standard
           therapy in Indian patients with melasma

    • Authors: Maya Vedamurthy, Philippe Humbert
      Pages: 471 - 478
      Abstract: Background: Melasma management is often difficult and unsatisfactory, and there is need to explore newer modalities for melasma treatment. Disruption in antioxidant balance occurs in melasma. Superoxide dismutase (SOD) is a cellular antioxidant and restores this balance. Our hypothesis is that the oral SOD-Gliadin can replenish the SOD stores in body and quench the ‘reactive oxygen species’-induced damage in melasma.Methods: A randomized, open label, single centre, comparative, five arm study was conducted in 90 patients with facial mixed melasma, for 12 weeks to evaluate the efficacy, safety and tolerability of two regimens (BD & OD) of oral SOD as add-on treatment with triple combination cream in melasma patients compared with two regimens (BD & OD) of beta-carotene (BC) and placebo. Primary outcome measure was improvement in Melasma Area and Severity Index (MASI) score, and secondary outcome measures were quality of life score, patient satisfaction score, global assessment by investigator and patients. Pair-wise comparisons were performed on adjusted mean using SAS v9.1.3.Results: There was significant reduction in MASI score with add-on treatment with SOD BD (67.97%) as compared to BC BD (43.04%), BC OD (33.68%) and placebo (22.60%). There was significant reduction in MASI score with SOD OD (51.93%) as compared to placebo (22.60%). The subjective assessments reported by patient and evaluator also ranked SOD BD as a superior regimen.Conclusions: By inhibiting oxidative stress, nutraceutical SOD-Gliadin Combination offers significantly better efficacy and higher treatment satisfaction as add-on treatment compared to beta-carotene in Indian patients.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184453
      Issue No: Vol. 4, No. 4 (2018)
  • Cutaneous manifestations and systemic correlation in patients with lupus
           erythematosus and its subsets: a study of 40 cases

    • Authors: Rashmi Mahajan, Kishan Ninama, Ishan Pandya, Rajvee Patel, F. E. Bilimoria
      Pages: 479 - 483
      Abstract: Background: The objective was to study various dermatological manifestations and clinical and laboratory features in patients of lupus erythematosus (LE) and its subsets.Methods: This is a cross sectional observational study done in a tertiary care hospital in a rural setup in Piparia, Ta. Waghodiya, Dist. Vadodara, Gujarat. All the patients with clinical features of LE and its subsets were included in the study over a period of 16 months and were subjected to detailed history taking, complete cutaneous and general examination and laboratory investigations.Results: Out of the 40 cases, 22 cases were systemic lupus erythematosus (SLE), 13 cases were discoid lupus erythematosus (DLE), four cases were of Rowell’s syndrome and one case was of mixed connective tissue disorder (MCTD). 97.5% of cases had cutaneous involvement, i.e. photosensitivity (77.5%), oral ulcers, hair loss and malar rash. Systemic symptoms and abnormal laboratory parameters were present in the cases of SLE, Rowell’s syndrome and MCTD, with hematological involvement being the most common in both SLE (77%) and Rowell’s syndrome (100%) and positive anti-nuclear antibody (ANA) titer being the most common abnormal laboratory finding in both SLE (95.4%) and Rowell’s syndrome (100%). The most commonly found antibody was anti-dsDNA (64.3%) in SLE and anti SS-A (100%) in Rowell’s syndrome.Conclusions: Cutaneous features though occasionally subtle, are pointers to a diagnosis of SLE. Hair loss, malar rash and photosensitivity alone or in association with altered hematologic/ANA profile are the key markers of the disease activity. 
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20183407
      Issue No: Vol. 4, No. 4 (2018)
  • Male urethritis with or without discharge: a clinico aetiological study in
           Hi-tech Medical College and Hospital Bhubaneswar, Odisha

    • Authors: Binayak Chandra Dwari, Mamata Bhatt, Minati Mishra, Nalinikanta Tripathy, P. K. Sathpathy
      Pages: 484 - 488
      Abstract: Background: Urethritis or inflammation of the urethra is a multifactorial condition. Urethritis is called gonococcal urethritis (GU) when Neisseria gonorrhoeae is detected in urethral smear of the patient and nongonococcal urethritis (NGU) when this organism cannot be visualized.Methods: Urethritis cases were identified from the dermatology OPD record. A retrospective analysis of data of patients diagnosed as GU and NGU for a period of 5 years (from August 2012-July 2017) was made. We have included only male patients more than 10 year.Results: Neisseria gonorrhoeae (61.42%) and Chlamydia trachomatis (45.9%) were the most common causative organism among urethritis and nongonococcal urethritis (NGU) respectively. Chlamydia urethritis had been confirmed by demonstrating ≥5 polymorphonuclear lymphocytes (PMNLs) from the anterior urethra using a Gram stained urethral smear. Acute condition (7-14 days) more common in GU. Dysuria and purulent urethral discharge (68.6%) was more common in GU. In urine specimen pus cells count were more than 10. The most common age group was 21-30 year (42.86%). Most patients were from low socio-economic status (62.85%). Sexual exposure was more common in unmarried patients (94.74%). Heterosexual exposure (93.75%) was more common. Urethritis was also associated with other infection in 18 patients.Conclusions: Urethritis is inflammation of urethra which is manifested by dysuria with or without urethral discharge. Though there is increased incidence of Chlamydia infections, still now Gonococcal infection is the most common cause of urethritis. 
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20183377
      Issue No: Vol. 4, No. 4 (2018)
  • Effectiveness and safety of a novel topical depigmenting agent in
           epidermal pigmentation: an open-label, non-comparative study

    • Authors: B. S. Chandrashekar, Chaithra Shenoy, Lakshmi Narayana N.
      Pages: 489 - 494
      Abstract: Background: Active compounds isolated from plants are known to inhibit melanogenesis without melanocytotoxicity. The aim of this study was to assess the effectiveness and safety of a cream containing a combination of niacinamide, glycolic acid, vitamin E acetate, kojic acid, soy isoflavones, arbutin, pterowhite, licorice and ascorbyl glucoside for the treatment of epidermal pigmentation.Methods: Sixty subjects (between 18-45 years) with epidermal pigmentation were enrolled in this 12-week, open-label, non-comparative study. Clinical/dermoscopic aspects (grade-1: <25%; grade-2: 25-50%; grade-3: 50-75%; grade-4: >75% reduction in the amount of epidermal pigment); melanin index/erythema measure (Dermacatch); extent, depth and density of pigmentation (FotoFinder) and safety were assessed.Results: Out of 60 enrolled subjects, 53 completed the study. Overall percentage of melanin and erythema improvement (Dermacatch) was 24.2% and 7.4% respectively (p<0.05). Based on Fotofinder images, 13% had grade 4 improvement, 47% had grade 3 improvement, 30% had grade 2 improvement while 9% subjects had grade 1 improvement. On the basis of clinical photographic images, 15% had grade 4 improvements in the skin colour, 41% had grade 3, 34% had grade 2 and 9% subjects had grade 1 improvement. Adverse effect of skin irritation was reported in one subject, which resolved after discontinuing the treatment.Conclusions: Cream containing a combination of niacinamide 4.0%, glycolic acid 2.0%, vitamin E acetate 0.1%, kojic acid dipalmitate 2.0%, soy isoflavones 0.5%, arbutin 2.0%, pterowhite 0.12%, licorice 40% CA 0.12%, ascorbyl glucoside 0.1% was found to be safe and effective in the treatment of epidermal pigmentation.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20183378
      Issue No: Vol. 4, No. 4 (2018)
  • Clinical evaluation of hirsutism in South India

    • Authors: R. Subha, G. K. Tharini
      Pages: 495 - 500
      Abstract: Background: Hirsutism is defined as the presence of terminal coarse hairs in women, in male distribution. Hirsutism affects approximately 5 to 10% of women of reproductive age. There are only very few studies from south India on associations of hirsutism. We analyzed the prevalence of hirsutism among different age groups, etiology and its associated conditions.Methods: This prospective study was conducted in the Department of Dermatology, of a tertiary hospital in south India over a period of two years. Patients with Ferriman Gallway score of 8 or more were included in the study. Complete history, examination and investigations including USG abdomen & pelvis, hormonal assay were done for all patients. All our patients were screened for metabolic syndrome.Results: A total of 73 patients with hirsutism were enrolled. Among them, 53 (72.6%) were in the age group of 15 to 35 years. Menstrual irregularities were seen in 35 patients (48%). Face was the commonest site of involvement. Serum total testosterone was elevated in 10 patients (13.7%). LH, FSH ratio was more than 2 in 12 patients (16.4%). Polycystic ovaries were seen on pelvic ultrasonogram in 20 patients (27.3%).Conclusions: Idiopathic hirsutism was the most common cause of hirsutism in our study. In our study 30% of patients were obese. Among them, features of metabolic syndrome were seen in 31.8%, though majority of our patients were young.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184459
      Issue No: Vol. 4, No. 4 (2018)
  • Drug eruptions and hepatic involvement: a study

    • Authors: Vimala Manne, Padmaja Pinjala
      Pages: 501 - 507
      Abstract: Background: Assessment by liver biopsy remains the gold standard in defining drug induced liver disease. Liver biopsy is an invasive procedure. Hence, a technique that is simpler is required to detect drug induced liver dysfunction. The profile of liver function tests (LFT) abnormalities, provides an initial guide to the clinical syndrome of drug induced hepatotoxicity. This study attempts to draw a possible correlation as well as to derive insight into the involvement of liver in drug eruptions through simple liver function tests.Methods: 112 cases of patients with drug rash whom we have a tendency to saw within the department of medicine as out-patients and in-patients since 2015 to 2018 in Osmania General Hospital, Katuri Medical College and Hospital and Dr. V. R. K Women’s Medical College, Teaching Hospital and Research Centre were enclosed during this study. Total number of cutaneous drug rash cases enrolled: 83 Total number of drug rash cases with Liver Function Test abnormalities: 17.Results: Out of 83 patients of drag rash 20% (17) had liver function test abnormalities while 80% (66) had normal hepatic function. Out of 17 drug rash cases with liver function test abnormalities 35% (6) were between 4-14 years of age group. Out of 17 drug rash cases with liver function test abnormalities 70.6% (12) were males and 29.4% (5) were females.Conclusions: To conclude, a sound knowledge of morphological patterns of drug rashes with hepatic involvement, drugs implicated in causing drug rashes and hepatic dysfunction and an easy detection of impending danger by the simple biochemical tests (liver function tests) can evert a major crisis and thus help the clinicians to better manage their cases.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20183819
      Issue No: Vol. 4, No. 4 (2018)
  • Clinical profile and risk factors of dermatophytoses: a hospital based

    • Authors: Abhineetha Hosthota, Trupthi Gowda, Rajini Manikonda
      Pages: 508 - 513
      Abstract: Background: Dermatophytoses are superficial mycoses which represents most common community health problem across the globe. Surveillance studies are required to understand the changing epidemiology and prevalence of causative agents to decide on appropriate therapy. This study aims to evaluate the clinical types, etiological agents and probable risk factors of dermatophytoses.Methods: It was a cross sectional study of 150 clinically suspected cases of dermatophytoses during six months. Sociodemographic details, clinical history and detailed examination were collected from all the subjects. Skin scrapings were sent to microbiology for direct microscopy and fungal culture.Results: Among the 150 subjects enrolled, males outnumbered females. Infection was mostly prevalent in the age group of 21-30 years (37.3%). Tinea cruris was the commonest clinical type (50%) followed by Tinea corporis (18.4%) and Tinea unguium (11.9%). Tricophyton rubrum was the aetiological agent isolated in majority (33%), followed by Tricophyton mentagrophytes (20%). The major risk factors of dermatophytoses were poor hygiene (32.1%), topical steroid usage (23.9%) and diabetes mellitus (20.1%).Conclusions: The present study has provided recent data on etiological agents of dermatophytoses and risk factors in our area. It is essential to develop measures for prevention, control of dermatophyte infections and establishment of therapeutic strategies.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20183860
      Issue No: Vol. 4, No. 4 (2018)
  • Clinical profile of palmoplantar dermatoses in patients attending tertiary
           health center in central India

    • Authors: Shyam Govind Rathoriya
      Pages: 514 - 517
      Abstract: Background: Palmoplantar dermatoses include specific skin diseases affecting palm and soles and are frequently encountered dermatoses in the dermatology practice. Apart from diagnostic difficulties, few palmoplanter dermatoses cause great discomfort and disability and may also affect a person's livelihood.Methods: It was a cross sectional descriptive study conducted in the Department of Dermatology, Chirayu Medical College and Hospital, Bhopal. A total of 200 patients of palmoplanter dermatoses, attending outpatient department of dermatology of tertiary health center were enrolled for study.Results: In our study, a total of 200 patients were included in the study, of which 116 (58.0%) were males and 84 (42.0%) were females. Male to female ratio was 1.38 showing male preponderance of disease. The most common age group affected was 31–40 years followed by 21–30 years in both the sexes. In our study, only palms were involved in 30 (15%) cases, soles in 39 (19.5%), and both palms and soles in 131 (65.5%) cases. Out of all palmoplanter dermatoses, 161 (80.5%) cases had palms and 170 (85%) cases had soles involvement. Palmoplantar psoriasis was the most common dermatoses found in 48 (24.0%) cases followed by palmoplanter keratoderma in 26 (13.0%).Conclusions: Early recognition of clinical symptoms and signs is important to plan further supportive diagnostic investigations as well as appropriate and effective management to further improve outcome of illness and the quality of life.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184221
      Issue No: Vol. 4, No. 4 (2018)
  • Clinico-epidemiological study of leprosy from a North Indian tertiary care

    • Authors: Mohammad Adil, Syed Suhail Amin, Mohd Mohtashim, Sabha Mushtaq, Mehtab Alam, Annu Priya
      Pages: 518 - 521
      Abstract: Background: Leprosy was eliminated as a public health problem in India in 2005. Yet, more than 60% of all new cases of leprosy are reported from India.Methods: A retrospective analysis of the records of patients attending the leprosy clinic of the Dermatology Out Patient Department was done for a period of one year from May 2017 to April 2018. The data was analysed for clinical and epidemiological characteristics of the patients.Results: A total of 225 patients visited the leprosy clinic during the study period. Almost half of all patients (47.1%) were aged between 21-40 years. Among the patients were 32 children (14.2%) below 16 years. There were 60 patients (26.6%) suffering from paucibacillary disease and 158 patients (70.2%) had multibacillary disease. Seven patients (3.2%) presented with other forms of leprosy like historic leprosy and pure neuritic leprosy. Borderline lepromatous leprosy was found to be the commonest subtype seen in 86 patients (38.2%). There were 152 males (67.6%) and 73 females (32.4%). The male female ratio was 2.08:1. A total of 118 patients (52.4%) were from rural background and 107 (47.6%) hailed from urban areas. Multibacillary disease was seen in 83.6% of the total females compared to 63.8% of males.Conclusions: Leprosy may be down but is not yet out. The high proportion of children diagnosed with leprosy is a warning regarding the active transmission of the disease in the community. Continued efforts are required to prevent the disease from making a resurgence.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184234
      Issue No: Vol. 4, No. 4 (2018)
  • Study of prevalence of metabolic syndrome in androgenetic alopecia

    • Authors: M. Mahitha Devi, P. V. Krishnam Raju, K. V. T. Gopal, T. Narayana Rao
      Pages: 522 - 526
      Abstract: Background: Androgenetic alopecia (AGA) is commonly known as male pattern baldness has a prevalence of up to 50% in men worldwide. It occurs in most patients before the age of 40 years. It is characterized by a progressive conversion of terminal hair into miniaturized hair defined by various patterns. Various studies have shown that androgenetic alopecia have significant physical and psychological morbidity and a lowered dermatological life quality index.Methods: The study included 75 patients with clinical diagnosis of AGA and 75 age and sex matched controls. After taking complete history, general examination and thorough dermatological examination was performed in all cases to grade the severity of AGA. Fasting serum samples were taken from all cases and controls and assayed for fasting plasma glucose and lipid profile. Metabolic syndrome (MS) was diagnosed according to 2005 revised National Cholesterol Education Programme’s Adult Treatment Panel III (NCEP ATP III). Chi square test was used for statistical analysis.Results: Metabolic syndrome was seen in 25 cases (33.3%) compared to 11 controls (14%), which was statistically significant (p=0.007). Statistically significant increased prevalence of raised TGL levels (p=0.002), raised LDL levels (p=0.024), low HDL levels (p=0.0001), diabetes mellitus (p=0.004) was also observed in AGA.Conclusions: There is a clear association between AGA and MS and there is statistically significant prevalence of MS in patients with increasing severity and duration of AGA. Screening is required for early detection of dyslipidemia, diabetes mellitus and MS in all patients of AGA to prevent long-term morbidity.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184454
      Issue No: Vol. 4, No. 4 (2018)
  • A clinical, epidemiological and histopathological study of leprosy

    • Authors: Perumalla Nataraj, Haritha Komeravelli
      Pages: 527 - 533
      Abstract: Background: Leprosy reactions are acute emergencies in the otherwise generally indolent course of leprosy. The present study was done to know the epidemiology, clinical manifestations and its histopathological findings..Methods: A total of 50 patients attending out patient, in the department of Dermatology, venereology and Leprosy at Chigateri Hospital and Bapuji Hospital were included. Detailed history, thorough physical examination and relevant investigations were done.Results: Out of all leprosy outpatients, reactions constituted 16.8%. 66% patients belonged to age group of 21-50 years, with a male to female ratio of 1.94:1. The disease was more common among the illiterates (80%), coolies (52%) and low socio-economic status (76%). Type I (RR) reaction (66%) and Type II (ENL) reaction (34%) which, commonly presented during 1st year of MDT and 2 years of MDT respectively. Borderline spectrum (74%), Anti-leprosy drugs (46%) were major risk factors associated. Erythematous, edematous skin lesions (50.6%); erythematous tender nodules (100%) along with neuritis were most common clinical features in Type I (RR) and Type II (ENL) reactions respectively. Edema (63.6%), lymphocytes (60.6%) and epitheloid cells (54.5%) were major histopathological findings in Type I (RR) reaction where as vasculitis (100%), increased vascularity (82.3%) and PMNL cells (88.2%) in Type II (ENL) reaction.Conclusions: This study emphasizes the need for detailed history, clinical examination and investigations including biopsy for timely recognition of reactions, in order to halt the progress and prevent the permanent damage it causes. 
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184455
      Issue No: Vol. 4, No. 4 (2018)
  • Retrospective analysis of demographic factors and changing pattern of
           clinical features of acquired syphilis at a tertiary care center in South

    • Authors: P. Sivayadevi, Heber Anandan
      Pages: 534 - 538
      Abstract: Background: Syphilis presents with a wide range of mucocutaneous and systemic manifestations, which can mimic many other diseases. The pattern of acquired syphilis is changing in recent years because of widespread use of antibiotics and HIV infection which leads to under diagnosis. Aim was to study the demographic factors and changing pattern of clinical features of acquired syphilis.Methods: Retrospective analysis of all cases of sexually transmitted infections registered in the Department of Venereology, Thanjavur Medical College from January 2013 to December 2017 was done. The data regarding epidemiological, clinical and investigational details were recorded and analyzed for changing trends in incidence, pattern and clinical presentation of syphilis.Results: Of the total 14,672 cases attended theSTI clinic, 140 patients were diagnosed as having syphilis. There were 101 (79.4%) males and 39 (27.8%) females. Primary Syphilis was diagnosed in 18 (12.25%), Secondary syphilis in 38 (27.14%) and latent in 84 (60%) cases. Palmoplantar syphilide was the most common skin manifestation seen in 20 (52.63%) cases of secondary syphilis. 11 (7.85%) patients was human immunodeficiency virus (HIV) reactive.Conclusions: Our study indicates an increasing trend in the prevalence of syphilis cases in last 5 years with a rise in early symptomatic syphilis demanding steps to increase awareness among the general population.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184456
      Issue No: Vol. 4, No. 4 (2018)
  • A clinico-epidemiological study of melasma

    • Authors: Akshy Kumar, Mukul Sharma
      Pages: 539 - 542
      Abstract: Background: Melasma is an acquired increased pigmentation of the skin, characterized by gray-brown symmetrical patches, mostly in the sun-exposed areas of the skin.Methods: The proposed study is an epidemiological cross sectional study which was carried out in the department of dermatology in a teaching institute from October 2007 to September 2008 at Pramukh Swami Medical College, Karamsad, Gujarat. A total of 60 patients were enrolled for the study over a period of one year.Results: The main age group affected was 30-39 years i.e. 48.33% patients. 50 patients were females.18 patients had a positive family history of melasma. 12 patients had a positive history of using OC Pills. Malar region was the commonest affected area found in 52 patients followed by Centro-facial in 31 and least involvement was seen in forehead region in 24 patients. 20 patients reported association of occurrence of the lesions with pregnancy, 09 patients reported sunlight to be the offending agent.Conclusions: Females were affected more commonly during their late third decade of life. Although we did not find the exact cause of melasma, we noticed that sun-exposure, pregnancy, and taking of oral contraceptive pills could precipitate or exacerbate the melasma.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184457
      Issue No: Vol. 4, No. 4 (2018)
  • Study of dermatological manifestations amongst patients with chronic
           kidney disease

    • Authors: Manish Kadam, Pranita Kadam
      Pages: 543 - 549
      Abstract: Background: The number of patients with end-stage renal disease (ESRD) in India is increasing with an estimated annual incidence of about 100 per million populations. Hemodialysis is one of the therapeutic modalities which can improve the survival in these patients. About 50–100% of patients with ESRD have at least one associated cutaneous change Skin problems are common and diverse in patients with chronic kidney disease (CKD), especially among those on hemodialysis. Objective was to study dermatologic manifestations among patients with chronic kidney disease on maintenance hemodialysis.Methods: A descriptive observational study was conducted in 77 consecutive chronic kidney disease patients receiving maintenance hemodialysis for more than 3 months at Manik Hospital, Aurangabad, Maharashtra, India.Results: Out of 77 patients, 51 (66.23) of males and 26 (23.67) of females were examined. Male: Female ratio was 1.96: 1. The mean age was 51.17±15.22 years. Seventy three (94.08) patients had at-least one skin manifestation. Xerosis was the commonest manifestation (87.01), followed by pruritus (57.14). Cutaneous infections were noted in 55.84% patients. Fungal infections were more common with 27.27%. Mild xerosis was noted in 55.84% patients, 24.67% patients were moderate and whereas severe xerosis was noted in 6.49% patients.Conclusions: Chronic kidney disease patients have prolonged life expectancy due to hemodialysis, hence they should be looked for presence of various skin manifestations which can affect the usual work and cause sleep disturbance which adds to the morbidity and mortality.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184458
      Issue No: Vol. 4, No. 4 (2018)
  • Effect of intralesional platelet rich plasma in chronic localized vitiligo

    • Authors: Rashmi Mahajan, Kishan Ninama, Hinal Shah, Freny Bilimoria
      Pages: 550 - 555
      Abstract: Background: Vitiligo is a disease caused by destruction of melanocytes in lesional skin. It occurs worldwide in occurance of 0.1 to 2.0 percent. It is a multifactorial polygenic disease with complex pathogenesis. Several treatments, old and new are advocated for such patients. The first line of treatment includes topical corticosteroids and calcineurin inhibitors, and phototherapy (NBUVB, PUVA). The second line of treatment includes systemic corticosteroids, topical calcipotriol 0.005%, lasers such as excimer laser (308 nm).  The aim of the study was to evaluate the efficacy of platelet rich plasma in 40 cases of stable vitiligo with less than or equal to 1% body surface area involvement.Methods: 40 cases of stable vitiligo not responding to adequate topical therapy for more than 1 year were included in the study. They were subjected to intralesional injections of freshly prepared autologous platelet rich plasma (PRP) by double spin technique. Each patient was given injections every 2 weekly interwals for a total of 6 injections. Results were evaluated using the vitiligo area severity index (VASI) score.Results: Out of 40 patients15 Patients showed good response, 12 patients showed Average response and13 patients showed no response to treatment according to VASI score.Conclusions: PRP may be considered as an additional therapy in patients not responding adequately to traditional therapies. Our patients were not subjected to histopathology. It was also felt that patients might require more than 6 sittings for complete repigmentation.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20183464
      Issue No: Vol. 4, No. 4 (2018)
  • Prevalence of vitiligo at the tertiary health care centre, Mc Gann’s
           teaching district hospital Shivamogga

    • Authors: Y. G. Anupama, Geetha Bhaktha, B. Manjula, H. J. Dadapeer, K. S. Govinda Swamy, R. S. Jyothi, L. H. Halesh
      Pages: 556 - 558
      Abstract: Background: Vitiligo is a common depigmentation disorder involving persons of all ages and both genders uniformly throughout the races. The highest incidence of vitiligo has been recorded in Indians from the Indian subcontinent, along with Mexicans and Japanese.Methods: Patients visiting Dermatology OPD were recruited for the study at the tertiary health care centre, Mc Gann’s teaching district hospital Shivamogga. Data regarding health-related status and other factors were collected between May 2016 and October 2017.Results: Among the potential candidates, 8.6% of our study population was with the positive family history of vitiligo and 50.9% were females and 49.1% were males. Patients with age from 27-36 years were found to be affected mostly. The most common site of onset was the lower limbs (30%) followed by head and neck (25.4%) with the commonest pattern to be of acro-facial type.Conclusions: This study suggests that local epidemiological behavior of vitiligo was not the same across different regions. Variations did exist and may possibly be due to certain clinico-epidemiological parameters of Shimoga viz., prevalence of associated diseases and its extent of involvement.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184460
      Issue No: Vol. 4, No. 4 (2018)
  • Various presentations of cutaneous tuberculosis at a tertiary care centre:
           a one year prospective study

    • Authors: N. S. Jayanthi, V. Anandan, S. Kopika
      Pages: 559 - 562
      Abstract: Background: Cutaneous tuberculosis is a rare manifestation of tuberculosis accounting for about 1.5% of all the extra pulmonary manifestations, though the prevalence of pulmonary tuberculosis is high in India. The aim of the study was to prospectively analyze the various clinical presentations of cutaneous TB and their age and sex distribution among the OPD attending patients over a period of one year.Methods: Prospective study, conducted during July 2016 to June 2017. Clinically suspected cases of cutaneous tuberculosis were subjected to lesional biopsy and the results obtained were analyzed.Results: Out of 36 clinically suspected cases, 24 turned out to be cutaneous tuberculosis and apart from these, 5 cases were referred from other departments as cutaneous tuberculosis. The predominant presentation was lupus vulgaris in 12 patients, followed by tuberculous verrucosa cutis in 8 cases, tuberculous ulcers in 3 cases and the remaining 2 cases were erythema induratum of Bazin. Among them, 13 were men accounting to about 52% and 7 were children which accounted for 28% and the remaining 5 were women which added to 20%.Conclusions: Though the cutaneous manifestations of tuberculosis is very rare, the recent years have shown a rising incidence especially among children and therefore requires a high index of suspicion in them since India has very high prevalence of tuberculosis as such.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184461
      Issue No: Vol. 4, No. 4 (2018)
  • A comparative study of the efficacy and safety of oral apremilast versus
           oral methotrexate in patients with moderate to severe chronic plaque

    • Authors: Vinma H. Shetty, Saumya Goel, Amita Murali Babu, Hafsa Eram
      Pages: 563 - 569
      Abstract: Background: Psoriasis is a chronic, inflammatory systemic disease. Methotrexate acts by inhibiting dihydrofolic reductase enzyme. Apremilast is an oral PDE4 inhibitor approved by US Food and Drug Administration for treatment of psoriasis.Methods: This is hospital based comparative study conducted from February 2018 to August 2018. Seventy patients above 18 years of age with chronic plaque psoriasis were divided into 35 patients in each group and were treated with oral Apremilast (30 mg twice daily) and oral methotrexate (15 mg per week in three divided doses with a 12-hour interval between doses and tab folic acid on methotrexate free days) and were evaluated every 4 weeks for a period of 16 weeks and followed-up at 24th week. Outcome was assessed on basis of psoriasis area-and-severity index score (PASI), psoriasis disability index (PDI) and clinical photographs.Results: % of improvement in Group-A patients (76.8%) after 16 weeks of treatment was relatively more (p<0.05) as compared to group B (71.5%). At the end of 16 weeks PASI score in methotrexate group was statistically significant (p<0.05) as compared to group B, PDI became 17.90±3.87 in group A and was statistically significant (p<0.05) as compared to group B which was 20.34±2.98. Side effects observed were comparatively less in group A patients.Conclusions: On comparing the two drugs, methotrexate was comparatively better tolerated and had better efficacy and safety. More studies are required to further prove the efficacy of Apremilast in treatment of psoriasis.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184462
      Issue No: Vol. 4, No. 4 (2018)
  • Analysis of cases of dermatological referrals and their systemic
           correlation in a tertiary care hospital in Gangtok: a prospective study

    • Authors: Rukma Lall Sharma, Rekha Sharma, Forhad Akhtar Zaman
      Pages: 570 - 573
      Abstract: Background: Practice of dermatology in a teaching hospital is not merely limited to inpatient and out patients’ management but also boost up the clinical knowledge of young medical graduates and medical students. Many dermatological diseases might be directly or indirectly associated or related with the primary diseases for which the patient is admitted in the hospital or it may also be the dermatological manifestation of systemic diseases.Methods: The aim of the study was to analyze the type of dermatological diseases referred from the indoor patients of various departments and to identify its relation to systemic diseases. Consecutive sampling was applied on 297 referrals of indoor patients from various other specialties with dermatological disease.Results: Out of 297 referrals majority, 145 were from the department of medicine and only one, the least number, from Gastroenterology. Maximum number of cases that encountered was the viral infection with 39 cases. 128 patients had dermatological manifestations of primary diseases or directly or indirectly related to it and the rest 169 fell in unrelated group.Conclusions: Dermatological referrals from other specialties was noted to be an eye opener to the no dermatologist and beneficial to the patients in terms of providing proper guidance and evidence based treatment avoiding unnecessary investigations. This also emphasizes the need for a proper training of young non dermatologists.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184463
      Issue No: Vol. 4, No. 4 (2018)
  • Treatment of periungual warts: comparison of topical 5% 5-fluorouracil and
           intralesional purified protein derivative in a South Indian teaching

    • Authors: Durgadevi S., Shridharan P.
      Pages: 574 - 578
      Abstract: Background: Verrucae or warts are common skin lesions caused by the human papilloma virus. Treatment of warts, particularly those in the periungual region is usually difficult, exhibiting resistance. Available conventional treatment modalities offer little hope in curing periungual warts. Thus, there is a need for a simple, reliable, non-expensive treatment for periungual warts. Aim was to determine and compare the efficacy of intralesional immunotherapy using purified protein derivative (PPD) and topical 5-fluorouracil (5-FU) under tape occlusion for the treatment of periungual warts.Methods: In this prospective comparative study, Group 1 (PPD) patients, intralesional injection of PPD is given in a randomly selected lesion every 3 weeks for a maximum of six sittings. For Group 2 (topical 5% 5-FU under tape occlusion), patients are advised to apply 5% 5-FU under occlusion on the lesion(s) selected for study during the night and left for 12 hours. This is done for 3 months. After completion of the treatment and after the declaration of the cure – follow-up is done for the next three months to look for recurrence.Results: Intralesional PPD had a significantly higher cure rate (88%) than that of topical 5-fluorouracil under occlusion (20%). The mean time taken for the resolution of the periungual warts was 6.6 weeks for intralesional PPD compared to 9.8 weeks for topical 5-fu under tape occlusion.Conclusions: The cure rate of intralesional PPD group (88%) was much higher than that of topical 5% 5-fluorouracil under tape occlusion group (20%). In the PPD group, the younger patients responded well and faster. There was no difference in cure rate among age groups in 5 FU group.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184464
      Issue No: Vol. 4, No. 4 (2018)
  • Incidence of steroid modified tinea in tertiary care centre Lucknow

    • Authors: Savita Chaudhary, Priyanka Shukla, Khushboo Gupta, Gaurav Paliwal
      Pages: 579 - 585
      Abstract: Background: Rampant use and abuse of topical steroids has led to increase in number of cases of superficial dermatophytosis of skin, nail and hair. In most of the cases they are resistant to topical as well as oral antifungals even after prolong course of treatment. Our study aims to analyse epidemiological and microbiological profile of steroid modified tinea (SMT).Methods: Clinically diagnosed tinea patients with history of usage of topical steroids were included in our study. Detailed history was taken and clinical examination along with KOH mount and culture was done.Results: 980 patients were screened of which 550 patients with history of using topical steroids were included in our study. Most common age group was 20 to 29 years with male: female of ratio approximately 3:1 and disseminated form was the most common variety. KOH mount was positive in 76% cases and culture was positive in 72% cases. Most common species came out to be T. Mentagrophytes followed by T. rubrum. Among non-dermatophyte group, Candida was the commonest.Conclusions: There is rise in incidence of dermatophytosis, especially steroid modified one and cases of disseminated tinea are rising.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184465
      Issue No: Vol. 4, No. 4 (2018)
  • Study of skin changes and associated diseases in pregnancy

    • Authors: Komeravelli Haritha, Perumalla Nataraj
      Pages: 586 - 590
      Abstract: Background: Pregnancy accounts for profound changes like endocrinal, vascular, metabolic etc. The body adjust to these changes by compensating. Most changes are temporary but some may be permanent. Skin also undergoes changes and can be a cause of anxiety. Hence identification and management and counselling of these changes are important. Objective was to study the skin changes and associated diseases in pregnancy.Methods: A hospital based cross sectional study was carried out among 100 pregnant women who were selected as per eligibility criteria of the study over a period of one and half year. Those women having skin conditions were included in the present study.Results: Among both primigravida as well as multigravida women the most common condition was linea nigra i.e. 80.4% and 93.9% respectively. Breast changes were seen in 12.2% of the multigravida women and none in primi. Only 18 women were found to develop the specific dermatoses of pregnancy. Among them the most common dermatoses was Prurigo of pregnancy in 66.7% of the cases 5% had bacterial skin infections. 9% had viral skin infections. 16% had scabies. 14% had fungal skin infections and among them, Tinea versicolar was more common. 3% had angular stomatitis.Conclusions: Dermatoses of pregnancy were common in the study sample. They need proper attention in order to treat, and manage properly and at the same time it needs psychological counselling to relieve anxiety among pregnant women.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184466
      Issue No: Vol. 4, No. 4 (2018)
  • Correlation of serum calcium levels with severity of psoriasis

    • Authors: Sunil Chaudhari, Sushil Rathi
      Pages: 591 - 594
      Abstract: Background: Recently it has been observed that psoriasis can be successfully controlled by use of vitamin D. This has attracted the curiosity into research on psoriasis and vitamin D as well as role of calcium supplements in the control of psoriasis. Studies have shown that psoriasis risk factor is hypocalcemia. The objective of the study was to analyse serum calcium levels in patients of psoriasis and correlation with severity of psoriasis in comparison with control subjects without psoriasis.Methods: This study recruited 80 subjects, of psoriasis (age and sex control subjects without psoriasis) attending Skin and STD department, Government Medical College Amritsar, Punjab. Both patients and controls studied during period of 2 year from June 2015 to May 2017.Results: Serum calcium levels were significantly lower in psoriasis patients than in controls. Serum calcium levels values in patients of mild severity (PASI <10), moderate severity (PASI: 11-20) and severe (PASI >21) were 9.00±0.20, 8.93±0.24 & 8.98±0.22 respectively.Conclusions: Serum calcium levels were found lower in psoriasis patients and there were no correlation with severity of psoriasis. Hypocalcemia is a risk factor of psoriasis.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184467
      Issue No: Vol. 4, No. 4 (2018)
  • A retrospective study on clinicopathological correlation of cutaneous

    • Authors: Rajkumar Kannan, Lakshmanan Chellappan, Sridhar Venu, Muthusubramanian Chandrasekar
      Pages: 595 - 599
      Abstract: Background: Cutaneous tuberculosis is a curable chronic infectious disease. The clinical presentation and histopathological interpretation of skin biopsy may show variations as various types of the disease exist. The clinical diagnosis should be confirmed by histopathological features before starting treatment for particular type of the disease.Methods: A retrospective hospital based study was conducted among patients in Chengalpattu medical college for last 3 years (May 2015 – April 2018) who had cutaneous tuberculosis. Skin biopsy taken from active lesion was stained with routine haematoxylin and eosin (H & E) stain.Results: Out of 20 cases, male to female ratio was 1.5:1. The age of the patients ranged from 11-68 years. Clinically, lupus vulgaris was the most common type of cutaneous tuberculosis with 35% cases followed by tuberculosis verrucosa cutis 20% cases, scrofuloderma 15% and atypical mycobacterial infections 10%, and least common types are lichen scrofulosorum 5% which correlates with the previous study of Aruna et al. Characteristic tuberculoid granulomas were seen in 71.4% cases of lupus vulgaris, all cases of scrofuloderma, lichen scrofulosorum and 80% of tuberculosis verrucosa cutis. The clinical and histopathological correlation was seen in 17 cases (85%).Conclusions: There can be overlap between different types of cutaneous tuberculosis with various other dermatological diseases, both clinically and morphologically and so correlation of clinical and histopathological features appears to be more useful for accurate diagnosis and typing of cutaneous tuberculosis. High clinical suspicion is necessary in cutaneous tuberculosis and early diagnosis and treatment are essential to prevent its complications.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184468
      Issue No: Vol. 4, No. 4 (2018)
  • Management of carbamazepine induced drug reaction with eosinophlia and
           systemic symptoms in Mediheal hospital-Nakuru, Kenya: a case report

    • Authors: Ramadhan L. Mawenzi, Dhiren Parikh
      Pages: 600 - 604
      Abstract: Adverse drug reactions (ADR) are undesirable events occurring as consequences of an ingested, injected or applied drug. Their spectrum can range from mild to severe reactions. Severe Cutaneous Adverse Reactions (SCARs) are diverse in presentation and in consequence. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a type of life-threatening SCAR which affects the skin as well as the internal organs. Various drugs can cause DRESS, but aromatic anticonvulsants, especially carbamazepine are considered the major culprits. The diagnosis of DRESS requires a high index of suspicion followed by an intense sign-searching clinical examination guided by established criteria. We report a previously healthy 53 year old man of Kenyan ancestry who developed fever, widespread maculopapular rash, swollen eyelids and cervical lymphadenopathy three weeks after carbamazepine. Liver enzymes were markedly elevated and he had lymphocytopenia and a positive serology for human herpes virus type 6 (HHV6). Using the RegiSCAR criteria a probable diagnosis of DRESS secondary to carbamazepine was made. His treatment involved discontinuation of the drug, intravenous hydrocortisone together with mild topical steroids. He remarkably improved and was discharged on oral prednisone and followed up for three consecutive months. The length of his hospitalisation was ten days. Carbamazepine has potential to provoke DRESS in patients of Kenyan ancestry. DRESS should be anticipated before and during use of carbamazepine for early recognition. Treatment of DRESS should involve the immediate withdrawal of offending drug and rapid initiation of systemic corticosteroids as well as application of diluted topical steroids to sooth the skin.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184469
      Issue No: Vol. 4, No. 4 (2018)
  • Iron-deficiency and pruritus: a possible explanation of their relationship

    • Authors: Antonella Tammaro, Camilla Chello, Marco di Fraia, Domenico Giordano, Francesca Magri, Verdiana Zollo, Francesca Romana Parisella, Gabriella De Marco
      Pages: 605 - 606
      Abstract: Pruritus of unknown origin is defined as itching lasting for more than 3 weeks without a clear identifiable cause. Aetiology of itching is wide ranging and includes chronic renal failure, cholestasis and internal malignancy. Iron deficiency has been described to be causative of pruritus but the mechanism underlying this association remains unclear. We report the case of a female patient with iron deficiency anemia and generalized pruritus, resolved after intravenous administration of iron-complex supplements and we explained a possible mechanism between this association.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184470
      Issue No: Vol. 4, No. 4 (2018)
  • The missing grains in Madura foot: imaging to the rescue

    • Authors: Gopinath V. P. K., Ali Rishad C. M., Farisa P. M.
      Pages: 607 - 610
      Abstract: Mycetoma or Madura foot is a chronic localized granulomatous infection caused by varied species of fungi or actinomycetes clinically diagnosed by active discharging sinuses containing ‘grains’. In atypical presentations or patients unwilling for invasive investigations, imaging essentially plays a key role in diagnosis and helps to differentiate actinomycetoma from eumycetoma. Here we present such an atypical case of unilateral foot swelling without sinuses–cryptic mycetoma. This 69 year old male from Kerala had a swelling over the left foot following trauma initially painless. An x-ray taken showed normal underlying bones with mild soft tissue swelling. To evaluate further USG was taken which showed fine hyperechoiec foci settled at the bottom of cavities highly suggestive of mycetoma. For confirmation USG guided biopsy was taken but was inconclusive. As patient was not willing for repeat biopsy, we advised non invasive MRI that revealed classical ‘Dot In Circle’ sign specific for mycetoma. The distinction that makes the case stand out is its absence of classical picture of discharging sinuses and the fact that imaging rather than histopathology helped confirm the diagnosis in mycetoma.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184178
      Issue No: Vol. 4, No. 4 (2018)
  • A case of confluent and reticulated papillomatosis of gougeret and

    • Authors: Tulika Rai, Ajay Kumar Vishwakarma
      Pages: 611 - 613
      Abstract: Confluent and reticulated papillomatosis (CRP) of Gougerot and Carteaud, a rare skin disorder of unknown etiology, was first described in 1927. It is an uncommon but distinctive icthyosiform dermatosis seen in young adults. It is characterized by persistent brown, scaly macules, papules, patches and plaques, localized predominantly on the neck, intermammary, interscapular regions and axillae. There are numerous therapeutic options - topical retinoids and systemic retinoids, oral antibiotics but none are very effective. We report this case because of its rarity.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184471
      Issue No: Vol. 4, No. 4 (2018)
  • Drug induced mucosal erythema multiforme

    • Authors: Anil P. Gosavi, Minal G. Jogi, Ravindranath B. Chavan, Sunil N. Tolat, Smrutirama M. Ramawanshi
      Pages: 614 - 616
      Abstract: Erythema multiforme (EM) is a hypersensitivity reaction to different antigenic stimuli, commoner being infection followed by drugs. It occurs predominantly in younger age group. EM has benign course but frequent recurrences are common especially secondary to HSV infection. Erythema multiforme present as classical cutaneous target/ targetoid lesions and mucosal bullae/erosions. Though almost 70% of patients suffer from mucosal involvement, isolated mucosal affection is very rare. Fuchs syndrome/ectodermosis pluriorificialis is a rare variant characterized by severe involvement of two or three mucosal sites in the absence of skin lesions commonly triggered by Mycoplasma pneumoniae. Here we are reporting a rare case of mucosal erythema multiforme secondary to drug and highlighting the importance of distinguishing it from other similarly presenting mucosal disorders.
      PubDate: 2018-10-25
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20184472
      Issue No: Vol. 4, No. 4 (2018)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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