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Intl. J. of Advances in Medicine     Open Access   (Followers: 2)
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International Journal of Research in Dermatology
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2455-4529
Published by Medip Academy Homepage  [12 journals]
  • Complications of fractional ablative carbon dioxide laser in various
           aesthetic procedures: a retrospective study

    • Authors: Jasleen Kaur, Saurabh Sharma, Tanreet Kaur, Roopam Bassi
      Pages: 664 - 667
      Abstract: Background: Though fractionated CO2 laser technology resurface patients with a lower rate of complications than non-fractionated ablative laser treatment, adverse effects can still occur even with the best technology.Methods: In this retrospective study we evaluated 65 patients for early and delayed complications after laser treatment with Sellas Cis-Fl™ fractional CO2 laser system of wavelength 106400 nm for various aesthetic indications over the period of 12 months from October 2017 to September 2018. Follow up was done for the period of 2 months after the last session to determine the nature and frequency of various complications. Patient’s subjective assessment of the complications was recorded in the form of patient subjective score (PSS) which ranged from 1 to 10.Results: In the current study, the most common aesthetic indication for fractional CO2 laser was post acne scarring (38.4%). The most common early side effects reported were erythema (95.38%) and burning sensation (92.30%) after the procedure. Post procedural dryness and edema was seen in 72.3% and 69.23% patients. Among the delayed complications most frequently observed was persistent erythema (46.15%) followed by post inflammatory hyperpigmentation (44.61%).Conclusions: Though fractional CO2 laser is relatively a safe procedure, undesirable sequelae may still occur as a result of inappropriate selection of laser parameter, injudicious patient selection, inadequate preoperative counselling and suboptimal postoperative care. Dermatologist should keep the possibility of all the side effects that can occur after fractional CO2 laser and must take appropriate precautions during the procedure to avoid them.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194657
      Issue No: Vol. 5, No. 4 (2019)
  • A randomised trial of 5% minoxidil versus combination of 5% minoxidil and
           oral spironolactone in treatment of female pattern hair loss

    • Authors: Nachiket Madhukarrao Palaskar, Nitin Dinkar Chaudhari, Garima Laxminarayan Balpande, Swapna Subhash Khatu
      Pages: 668 - 672
      Abstract: Background: Female pattern hair loss (FPHL) is a common form of nonscarring hair loss. We compared the usefulness and safety of topical minoxidil alone with combination of oral spironolactone and topical minoxidil in the treatment of FPHL.Methods: This prospective, single-centre, randomised open label study over 100 patients attending tertiary care hospital in Mumbai during period December 2011 to June 2012. The data were entered into SPSS version 21 for analysis. Data collected were coded and described as frequency and percentage for qualitative data and means and standard deviation for quantitative data. Statistical analysis was done using chi-square and student t test. Statistical significance was considered if p value was less than 0.05.Results: There were 48 patients in Group I and 46 patients in Group II. At 6 months, significantly higher mean Sinclair grade was observed among Group I patients as compared to Group II patients (2.85±0.68 vs 2.56±0.50, p=0.02). We observed a significant improvement in women’s androgenetic alopecia quality of life questionnaire in Group I patients at 12 months after treatment (26.93±2.25 vs 23.47±2.95, p<0.001). Minoxidil and spironolactone were tolerated well by the patients.Conclusions: Combination therapy of topical minoxidil and oral spironolactone has an additive effect. However, plateau of effectiveness of the combination therapy in normoandrogenic patients at 6 months of therapy was observed. We recommend the combination for 6 months and continuation of therapy with minoxidil only.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194565
      Issue No: Vol. 5, No. 4 (2019)
  • A prospective observational study on efficacy of black acetic acid
           combination peel in patients of facial nodulocystic acne

    • Authors: Raj Kumar, Prasoon Sachan, Santosh Kumar Singh, Anil Kumar Gupta, Lalit Mohan
      Pages: 673 - 677
      Abstract: Background: Nodulocystic acne is a severe form of acne which can result in significant damage to the skin with great impact on quality of life. Oral isotretinoin is considered to be the best treatment for such cases. Although it has a high rate of success and its efficacy is well established in the treatment of nodulocystic acne, it may occasionally fail to meet expected degree of disease control. Known side-effects and long duration to achieve cumulative dose might lead to poor compliance and known contraindications sometimes as well limit its usage.Methods: A prospective observational studies on 20 patients who presented themselves with facial nodulocystic acne on regular OPD basis and were poorly compliant to treatment with isotretinoin owing to its side-effects, the drug failed to meet patients’ expectations or due to any contraindication to isotretenoin usage were included. A peel containing black acetic acid, jasmonic acid, salicylic acid, potassium iodide (“black peel”, Theraderm) was used topically as an alternative treatment, for a course of 3 treatment sittings 2 weeks apart.Results: Significant reduction of nodulocystic lesions was noted after 3 sittings of “black peel” 2 weeks apart. Among 20 patients 55% showed excellent response; 45% showed good response while none of the patients were non responsive. Post treatment ISGA score of 0.45 as opposed to pre-treatment score of 3.70 (p<0.0001) was observed.Conclusions: Black peel can be used as promising and hopeful alternative treatment for difficult to treat nodulocystic acne.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194544
      Issue No: Vol. 5, No. 4 (2019)
  • Clinical and histopathological profile of benign appendageal tumours of
           skin: a descriptive study from Andhra Pradesh

    • Authors: Prathyusha Pathakamuri, Venkateswaramma Begari, Anant A. Takalkar
      Pages: 678 - 681
      Abstract: Background: Skin adnexal tumors are those neoplasms that arise from pilosebaceous units, eccrine sweat glands or apocrine sweat glands. Vast majority of appendageal tumors are benign and most of the benign skin adnexal tumors are asymptomatic papules or nodules and often difficult to diagnose clinically. The objective of the study was to study the clinical and histological features suggestive of benign skin appendageal tumors.Methods: This is a descriptive observational study conducted among 50 patients presenting with clinical features suggestive of benign skin appendageal tumors attending at outpatient department of DVL, Kurnool medical college/ GGH, Kurnool between January 2016 to June 2017.Results: The highest age incidence was in the age group of 21-30 years- 24 cases (48%). The commonest tumors in this study were eccrine gland tumors i.e 43 cases (86%). Syringomas were the commonest tumors (38 cases, 76%). Commonest presenting lesion was papule (82%). Commonest site is face (94%).Conclusions: The commonest tumors recorded were eccrine gland tumors (86%). Syringomas constitute the largest group (76%) followed by trichoepitheliomas (6%). The highest age incidences was in 3rd decade (48%), followed by 4th decade (42%).
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20193853
      Issue No: Vol. 5, No. 4 (2019)
  • Association of psoriasis with metabolic disorders and their assessment
           using epicardial fat thickness, serum lipid profile and homocysteine level

    • Authors: Suryakant Ojha, Rajkumar ., Santhosh Singh, Anil Gupta, Amit Kumar Pandey, Sunil Prajapati
      Pages: 682 - 685
      Abstract: Background: Psoriasis is a chronic immune-mediated inflammatory disease with worldwide prevalence of 2-4%. It is characterized by sharply demarcated erythematous plaque lesions with silvery white scales. A number of literatures have been published concerning that psoriasis is associated with several cardio-metabolic co-morbidities thus increasing the risk of cardiovascular disease and cardiovascular mortality.Methods: A prospective observational study was done on patients attending Department of DVL, BRD Medical College, Gorakhpur with psoriasis. A total of 150 patients were enrolled for a study period of 1 year from 15th December 2017 to 31st December 2018. Statistical analysis was done using Statistical package for the social sciences (SPSS version 16.0).Results: According to our study mean basal metabolic index in psoriatic patients was 27.4±3.9. The mean cholesterol was 198±38 mg/dl, mean low density lipoproteins 129.5±34 mg/dl, mean triglycerides 140±75 mg/dl which is towards higher side, mean homocysteine being 19.5±1.5 µmol/l while the normal range is 4-15 µmol/l. Epicardial fat thickness on ultrasonograpghy was found to be 7.4±0.5 mm in psoriatic patient.Conclusions: Psoriasis may elevate the risk of atherosclerosis, particularly cardiovascular disorders. Therefore, from the epidemiological point of view screening of psoriatic patients, particularly those with severe psoriasis should be recommended.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194564
      Issue No: Vol. 5, No. 4 (2019)
  • Efficacy of autologous platelet rich fibrin matrix in the management of
           non-healing ulcers

    • Authors: Prachi V. Gole, Naziya Muhammed, Siddhi R. Patadia
      Pages: 686 - 690
      Abstract: Background: Non healing ulcers have a worldwide prevalence of 1.9%-13.1% with lower extremity being the commonest site. They are difficult to manage for the physician and frustrating for the patient due longer duration of treatment, cost, unsatisfactory outcomes and impairment caused due to them. Standard conventional management may fail at times and hence growth factors derived from platelets have been tried in the management of these ulcers. The purpose of our study was to evaluate the efficacy of platelet rich fibrin matrix (PRFM) in treatment of these ulcers.Methods: Twelve patients with fifteen non-healing ulcers more than 3 months duration were included in the study. 10cc of venous blood was withdrawn in plain tube without anti-coagulants and centrifuged at 1500 rpm for 14 minutes as early as possible as per advanced PRF protocol. Middle layer of PRFM was applied to the clean ulcer followed by a secondary dressing. All patients received PRFM sittings every 7-10 days or till ulcer healed. Baseline photographs and measurements of length, breadth and depth were taken to calculate the area of ulcer at every sitting.Results: The average percentage reduction in area and volume of the ulcer was 95.84% and 98.18% respectively at the end of six sittings. Twelve out of fifteen ulcers showed complete healing by 6 weeks, while three ulcers showed significant improvement but did not heal completely. The procedure was safe, well tolerated without any side effects.Conclusions: Platelet rich fibrin matrix is a novel modality and an ideal, safe, affordable therapeutic option for non-healing wounds of varied causes.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194566
      Issue No: Vol. 5, No. 4 (2019)
  • A study on incidence of oral lesions in lichen planus

    • Authors: Divya G., Jayakar Thomas
      Pages: 691 - 694
      Abstract: Background: This study was done to evaluate the incidence of oral lesions in different types of lichen planus.Methods: A total of 30 patients clinically diagnosed with any form of lichen planus were subjected to a clinical examination and evaluated for the presence of oral lesions.Results: Of the 30 patients in this study with predominantly females, oral involvement was seen in 17 patients with a slight male preponderance. Lichen planus was seen commonly between the ages of 20 and 40 with the incidence of oral lesions following the same trend.Conclusions: This study has statistically proven the significance of oral involvement in cutaneous lichen planus and was done to highlight the importance of the same. Oral lichen planus can be a forerunner of genital involvement as well as malignancies and it is important to keep this in mind while examining a case of lichen planus. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194658
      Issue No: Vol. 5, No. 4 (2019)
  • Cutaneous manifestations in obese patients and non-obese controls in a
           tertiary care centre: a case-control study

    • Authors: Raghuveer Chekuri, Thameena Mohamed
      Pages: 695 - 700
      Abstract: Background: Obesity has emerged as one of the most serious public health concerns in the 21st century. It is responsible for varied changes in structure and function of different components of skin. Skin care of obese patients deserves particular attention, not only because of high prevalence of cutaneous alteration but mainly because many of these disorders are preventable and could be treated, improving patient’s quality of life.Methods: Two hundred patients with BMI ≥30 kg/m2 and two hundred age and sex matched controls (BMI: 18.5-24.9 kg/m2) were included in this study.Results: Compared to the control group, obese patients were having higher prevalence of various skin conditions of which most common were acanthosis nigricans, acrochordons, striae distensae, frictional hyperpigmentation and infections.Conclusions: There is increased incidence and severity of cutaneous manifestations like acanthosis nigricans, acrochordons, striae distensae, frictional hyperpigmentation and infections in obese patients than control subjects. These can be used as markers for the early detection of various components of metabolic syndrome.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194633
      Issue No: Vol. 5, No. 4 (2019)
  • Study of clinical profile and association of severity with contact
           sensitivity of hand eczema patients

    • Authors: Shahid Hassan, Ashutosh Ranjan
      Pages: 701 - 705
      Abstract: Background: This present study was to evaluate the clinical profile, severity and its pattern as well as association between contact sensitivity with its severity in hand eczema patients.Methods: A detailed demographic profile, occupation, history regarding onset of disease, duration, progress of hand dermatitis, aggravating and relieving factors, seasonal variations, presence of atopy in self or family, day to day work, hobbies, and past and present treatment were performed to all cases of hand eczema. Severity of hand eczema was assessed by using hand eczema severity index (HECSI). Patch test was applied to all cases with standard Indian patch test battery as approved by contact dermatitis and occupational dermatoses forum of India. Data was applied by using SPSS version 26 software. P value was taken equal to or less than 0.05 for significant differences.Results: Hand eczema was commonly seen in male and middle age group (31-45 years) patients. Masons, house wives and farmers were mostly infected with hand eczema. Hyperkeratotic eczema and wear and tear dermatitis were the most common type of hand eczema. Potassium dichromate and nickel were the most common antigen/allergens. HECSI score 40-60 was seen in majorities of hand eczema cases. And there was no statistical significant association seen in between severity and positive patch test sensitivity in patients with hand eczema.Conclusions: Works associated with exposure to various chemical agents are at higher risk for developing hand eczema. Our study will of immense help to patients for identification of contact sensitizer and prevention from hand eczema.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194567
      Issue No: Vol. 5, No. 4 (2019)
  • A prospective observational study of follicular unit excision grafting for
           the management of stable vitiligo

    • Authors: Raj Kumar, Sunil Kumar Prajapati, Santosh Kumar Singh, Anil Kumar Gupta
      Pages: 706 - 710
      Abstract: Background: Vitiligo is a common acquired idiopathic and often, familial hypomelanosis, which is characterized by pale white macules that enlarges centrifugally over time. In India, vitiligo is associated with marked social stigma, thus demanding its effective management. Stable vitiligo lesions known to be relatively refractory medical therapy require surgical therapies like skin grafting or grafting of invitro cultured and non-cultured melanocytes or follicular unit excision (FUE) grafting.Methods: A prospective observational study was done on patients of stable vitiligo. A total of 20 patients were enrolled and underwent FUE grafting for study of effectiveness and complication.Results: A total of 20 patients of stable vitiligo were studied with or without leukotrichia in which good to excellent response was seen in 13 (65%), fair in 6 (30%) and poor in 1 (5%) patients.Conclusions: FUE is a superior and upcoming methodology which is cost effective, reliable, less disfiguring, very low morbidity and results in good color match in patients with stable vitiligo.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194568
      Issue No: Vol. 5, No. 4 (2019)
  • Penile beads and its associated infections: a descriptive study

    • Authors: Ram Kanta Halder, Pradeep Balasubramanian
      Pages: 711 - 714
      Abstract: Background: Practice of introducing glass beads in the penis has been done amongst the poachers from the neighboring countries of Andaman and Nicobar Islands, e. g. Myanmar, Thailand and Indonesia to improve their sexual performance.Methods: Patients attending the skin OPD, G.B. Pant Hospital and the poachers in the District Hospital, Pothrapur with beads and foreign body introduced in the penis were included in this study.Results: Totally 41 patients were enrolled in this study. All the patients were poachers (from Myanmar and Thailand). About 90% had inserted glass beads into the prepuce and 10% had injected oil. About 17% and 36.58% of these poachers were suffering from HIV infection and other sexually transmitted infections respectively. About 19.5% of the poachers had syphilis.Conclusions: It is observed that this peculiar sexual habit or behavior cause increased incidence of sexually transmitted diseases and AIDS in these poachers and hence it is a risky practice.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194247
      Issue No: Vol. 5, No. 4 (2019)
  • Comparison of cryotherapy versus intralesional measles, mumps, rubella
           vaccine versus their combination therapy in Indian patients with cutaneous
           wart: a single centre prospective observational study

    • Authors: Mithila Uday Vanarase
      Pages: 715 - 721
      Abstract: Background: Need for more effective and less time consuming therapeutic method is current necessity for treatment of cutaneous warts. The objective of the study was to evaluate and compare the efficacy, safety of cryotherapy versus intralesional measles, mumps, rubella (MMR) vaccine versus combination of cryotherapy and intralesional MMR vaccine in Indian patients with cutaneous wart.Methods: This prospective observational study was conducted in 60 patients of cutaneous warts. Patients were divided into three groups viz., group A, group B and group C. Group A was treated with cryotherapy alone, Group B received intralesional injection 0.1 to 0.3 ml of MMR vaccine alone and Group C received combination of group A and group B therapy. In each group treatment was repeated at 3 week interval for a maximum of 4 sittings. Percentage of improvement was evaluated using visual analogue scale (VAS) for local as well as distant (non-inoculated) warts. Follow-up was made every 2 months till 4 months to detect any recurrence.Results: For local warts in second half of treatment (12th week) patients of Group B and Group C showed significantly better response than patients in Group A. For distant warts in first half of treatment session patients showed significantly better response to Group C than as compared to Group B therapy (p<0.039).Conclusions: Immunotherapy with MMR is superior treatment than cryotherapy for cutaneous warts with minimum side effects but the combination of cryotherapy with intralesional MMR has shown to have complementary effect in treatment response.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20193852
      Issue No: Vol. 5, No. 4 (2019)
  • A retrospective clinicopathological study of cases of perforating
           dermatoses in a tertiary care centre

    • Authors: Saradha Kandasamy, Prathiba Subramanian, Geetharani Gopalan, Ashwini Krishnamoorthy
      Pages: 722 - 727
      Abstract: Background: Perforating deramtoses is a group of diseases characterized by extrusion of dermal materials such as inflammatory cells or extracellular substances through the epidermis. They can be classified as primary and secondary perforating dermatoses. This study was done to assess the prevalence and associated systemic diseases of perforating dermatoses in our setting.Methods: This is a retrospective study done by reviewing the hospital records of patients who attended the skin OPD, Government Rajaji Hospital, Madurai Medical College, Madurai during the period June 2008 to June 2010. All patients diagnosed clinically as perforating dermatoses and supported by histopathological examination were included.Results: Kyrle’s disease (54%) was the commonest type, followed by reactive perforating collagenosis (43%) and perforating calcific elastosis (3%). About 53% of the patients presented as hyperkeratotic papules and 43% as hyperkeratotic, plugged, umbilicated papules and plaques. Erythematous papules arranged in annular and serpiginous pattern in the periphery of the central atrophic plaques were noted in 1 patient (3%). Lower extremities (73%) were the most commonly involved site. (67%) patients had at least one systemic disease and commonest association was diabetes mellitus (53%), chronic renal failure (36%), hypothyroidism (3%).Conclusions: Perforating dermatoses is a uncommon dermatological condition characterized by Trans Epidermal Elimination of dermal substances. Since it has a strong association with systemic diseases screening for systemic diseases is required for all cases.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194563
      Issue No: Vol. 5, No. 4 (2019)
  • Prevalence and molecular characterization of human herpes virus 6 and 7 in
           patients with pityriasis rosea using polymerase chain reaction in a
           tertiary care hospital, Puducherry

    • Authors: Rangaraj Murugaiyan, Karthikeyan Kaliyaperumal, Balamurugan Rangasamy
      Pages: 728 - 731
      Abstract: Background: Human herpes virus (HHV) 6 and 7 belongs to Betaherpesviridae a sub-family of Herpesviridae. HHV-6 and HHV-7 are double stranded DNA group viruses. The cause of PR and the disease caused by HHV is not well established. The association of HHV 6 and HHV 7 with pityriasis rosea (PR) is under controversy. The HHV DNA is also detected in normal controls which evidence the non- significance of HHV in the pathogenesis of PR.Methods: The study design was planned for 35 consecutive cases of pityriasis rosea of all age groups. This study was carried out at the department of Dermatology and Central Research Lab, at Sri Manakula Vinayagar Medical College and Hospital, a tertiary care hospital in Puducherry. Since there is no universally accepted diagnostic protocol for PR, we have planned to detect HHV-6 and 7 DNA by PCR from the lesions of all clinically diagnosed cases of pityriasis rosea.Results: In contrary to the expected outcome that HHV-6 and HHV-7 positivity would correlate to the possible pathogenesis of the disease, the PCR results of all the 35 samples from clinically suspected PR cases were found to be negative.Conclusions: We conclude that HHV-6 and HHV-7 viruses may not always play a role in the pathogenesis of the disease. Thus PR speculated to have more than one etiology may have agents other than HHV6 and HHV7 involved in the pathogenesis of the disease.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194632
      Issue No: Vol. 5, No. 4 (2019)
  • Comparative assessment of psoriasis area and severity index and fasting
           blood sugar levels in psoriatic patients with diabetes mellitus

    • Authors: Devendra Parmar, Dhairya Salvi
      Pages: 732 - 735
      Abstract: Background: Present study was done with objectives to study the co-relation between PASI and Fasting blood sugar (FBS) levels in psoriatic patients with diabetes mellitus and to study the association between duration of topical steroid therapy and Fasting blood sugar (FBS) levels.Methods: Present study was conducted in the 26 patients at the Department of Dermatology at a tertiary care centre in Bhuj, Gujarat. A detailed history on the type of psoriasis, duration, associated co-morbid conditions and details of topical steroid therapy was obtained from all patients. They were examined in detail and assigned a PASI score to assess the severity of psoriasis. Patients with nail involvement were scored using N NAIL tool. Fasting blood sugar levels were noted in patients with Diabetes.Results: Age of patients ranged from 15 years to 72 years. The different types of psoriasis observed were palmoplantar psoriasis-14 (50%), and chronic plaque psoriasis - 11. The joint was involved in 7 patients while 19 did not have joint involvement. The Pearson co-relation coefficient between PASI and FBS was 0.60 and p value was 0.001. The Pearson co-relation coefficient between duration of topical steroid therapy and FBS was 0.15, and p value was 0.50.Conclusions: A statistically significant positive correlation between PASI and FBS was noted in this study. The duration of topical steroid therapy was not associated with significant changes in FBS in psoriatic patients with diabetes mellitus. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194659
      Issue No: Vol. 5, No. 4 (2019)
  • A study on thyroid dysfunction in acne vulgaris

    • Authors: Shreya Srinivasan, Jayakar Thomas
      Pages: 736 - 738
      Abstract: Background: This study was done to evaluate the role of thyroid function i.e., free T3, free T4 and thyroid stimulating hormone (TSH) in relation to the occurrence of acne vulgaris.Methods: A total of 50 patients clinically diagnosed with acne vulgaris were subjected to a thyroid function test and results were evaluated.Results: While all the 50 patients had normal free T3 and free T4 levels, 9 (18%) of the 50 patients displayed an elevated TSH level. Gender distribution among the patients with elevated TSH learned more towards the male population with 6 patients while there were only 3 female patients with elevated TSH.Conclusions: There have been few studies regarding the role of thyroid function in acne vulgaris in relation to free T3, free T4 and TSH, though the presence of thyroid antibodies have been highlighted in quite a few studies. This study has shown the insignificance of thyroid function in acne vulgaris thus accentuating the negative.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194660
      Issue No: Vol. 5, No. 4 (2019)
  • A cross-sectional observational study on child sexual abuse

    • Authors: Saradha Kandasamy Perumal, Sarankumar Sudhakar, Mithra Sampathkumar
      Pages: 739 - 742
      Abstract: Background: A child sexual abuse (CSA) incident never comes into limelight unless it is a rape, probably because it could be an asymptomatic event causing only an emotional trauma or due to fear of revealing. It has been observed that sexually transmitted infections (STI) are in increasing trend among adolescents due to early sexual maturity, increased promiscuity and sexual offenses.Methods: An observational cross-sectional study was carried out for a group of 774 school children between the age group of 14-17 years using a structured questionnaire to estimate the level of unreported child sexual abuse and sexual awareness. Descriptive statistical analysis was carried out in this study (SPSS 21.0).Results: It was observed that 5.5% of children had been abused among which 37.3 % and 62.7% were males and females respectively. 11.1% and 6.25% were abused in penetrative, 59.25% and 43.75% in non-penetrative forms among female and male victims respectively. Abusers were mainly family and friends (25.5%) followed by strangers (23.2%). 25.3% of unaffected and 27.9% of affected was aware of POSCO law. 88.3% of affected and 62.3% of unaffected rated good and above for the questionnaire.Conclusions: Unreported and silent victims have to be identified and addressed to prevent crimes and provide a safer environment for children. Implementation of POCSO law at the root level with sex education must be strengthened. Our study concluded that CSA is an extensive problem and even the lowest prevalence includes a huge number of victims who still need to be considered.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194661
      Issue No: Vol. 5, No. 4 (2019)
  • Resurgence of leprosy in post elimination era

    • Authors: Swapna Subhash Khatu, Nachiket Madhukarrao Palaskar, Garima Laxminarayan Balpande, Nitin Dinkar Chaudhari
      Pages: 743 - 750
      Abstract: Background: Leprosy is a slowly progressive mildly infectious disease caused by Mycobacterium leprae primarily affecting skin and peripheral nerves. After introduction of multidrug therapy in the country recorded leprosy case load has come down. In December 2005, India announced elimination of leprosy as public health problem at national level under the NLEP but new cases are still being registered.Methods: It was a hospital based cross sectional study conducted on over 109 leprosy patients attending a tertiary care hospital in Narhe, Pune during the period from 1st January 2018 to 31st December 2018. The statistical package for Social Sciences (SPSS) for Windows version (16.0) was used to analyze the data (SPSS Inc., Chicago, IL). Statistical significance was declared at p<0.05 or mentioned otherwise.Results: Out of 109 patients, 57 were new and 52 were old. Maximum patients belong to age group 40-49 years, 25 patients had type 1 reaction and 18 had type 2 reaction. Out of which 83 were on treatment and 12 are defaulter, 9 were in relapse, 6 patients released from treatment.Conclusions: In post elimination era of leprosy still new cases have been registered and hence the burden and morbidity of the disease is still high in the community. It strongly suggests that by early detection, increasing the duration of treatment and by increasing the community awareness, utilizing information, education and communication at all levels, we can hope to reduce the burden of disease in the community and to achieve the dream of leprosy free India. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194182
      Issue No: Vol. 5, No. 4 (2019)
  • A comparative study of effectiveness of autologus serum therapy with oral
           antihistamines versus oral methotrexate and oral antihistamines in chronic
           urticaria patients

    • Authors: Amit Kumar Pandey, Suryakant Ojha, Aayushi Mohan, Sunil Prajapati
      Pages: 751 - 755
      Abstract: Background: Chronic urticaria (CU) is a worrisome problem and patients of CU suffer from the morbidity that arises from irritable itch thus they are subjected to a huge antihistamine pill burden. The symptoms are more prominent in autoreactive urticaria (AU) where auto-antibodies in blood causing recurrent flares. Therefore a need of adjunctive drug to reduce the pill burden is felt need.Methods: A randomized, controlled study was done. 50 patients were given AST and 50 patients were given oral pulse methotrexate (10-15 mg once weekly) along with levocetrizine in an on-demand basis in both groups. AST was given weekly for nine weeks and followed-up for a total period of 24 weeks. Urticaria total severity score (UTSS) was used to evaluate the effectiveness of treatment. Safety parameters assessed were the spontaneously reported adverse events and laboratory parameters.Results: UTSS showed significant improvement from baseline, 7th week and 8th week onwards in AST group and methotrexate group respectively. Group comparison showed significant improvement 4th week onwards.Conclusions: Autologous serum therapy as well as methotrexate both proved effective in chronic urticaria patients. On follow-up improvement is sustained for at least 3-4 months after the last injection in case of AST. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194662
      Issue No: Vol. 5, No. 4 (2019)
  • A prospective study on the prevalence of neurally mediated hypotension in
           systemic lupus erythematosus

    • Authors: Rajkumar Kannan, Jayakalyani Vijayananth, Sridhar Venu, Muthusubramanian Chandrasekar
      Pages: 756 - 759
      Abstract: Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease which affects skin and organ systems. Cardiovascular manifestations are one of the important cause for mortality and morbidity in SLE. Neurally mediated hypotension (NMH) caused by autonomic neuropathy is found to be associated with fibromyalgia responsible for chronic fatigue syndrome in SLE. Our study aims to find the prevalence of NMH in SLE.Methods: This is a prospective study conducted in the Department of Dermatology, Chengalpattu Medical College from May 2017 to December 2018. All SLE patients who attended the Dermatology OPD were included in the study. The diagnosis of SLE was made based on the ARA criteria. After obtaining informed consent, baseline blood pressure of all patients included in the study were recorded. In patients with low blood pressure other causes of hypotension were ruled out. Patients with no discernible cause of hypotension were subjected to the two stage tilt table test. A drop in systolic BP of >20 mm of Hg or diastolic BP of >10 mm of Hg is considered to be positive.Results: A total of 20 patients were included in the study, of which 19 were female and one male. The mean age was 31.7 years. 70% of the SLE patients included in our study were found to have NMH.Conclusions: Neurally Mediated Hypotension was found to be highly prevalent in SLE.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194663
      Issue No: Vol. 5, No. 4 (2019)
  • A prospective study of pattern of keloid and number of intralesional
           triamcinolone acetonide injections in a community based dermatology clinic
           in Lagos, Nigeria

    • Authors: Ehiaghe L. Anaba, Irene Akwara, Omobolanle Johnson
      Pages: 760 - 764
      Abstract: Background: Keloid a benign tumor of the skin is said to be common in Africans, Hispanics and Asians. Triamcinolone acetonide is a known treatment for keloid and patients come to the clinic asking how many times they need to come in for treatment. The number of times patients need to be injected is not clearly documented. The aim of this study was to document the socio-demographic factors, symptoms, clinical characteristics and determine how many times patients need to be injected with triamcinolone acetonide.Methods: This was a prospective descriptive study over a one year period in the outpatient Dermatology clinic of the General Hospital Lagos. Eighty six (86) patients were studied. Patients were clinically evaluated for keloid, a structured questionnaire for socio-demographic variables was administered to the patients. Patients were treated mainly with intralesional triamcinolone (40 mg/ml) every six weeks. Data was analyzed using the Epi-info 7.Results: There were 47 men and 39 women. The mean age of the patients was 33.18±13.37 years. Keloid was found to occur mainly in people aged 20-29 years (45.88%). The commonest anatomical location was the head and neck (45.88%) with multiple keloids in 44.70%. Patients were injected on the average 4 times irrespective of the length of keloid.Conclusions: Keloids are common, occur mostly in the third decade of life and require 3-5 injections of triamcinolone acetonide.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194664
      Issue No: Vol. 5, No. 4 (2019)
  • Assessment of physical and dissolution characteristics of various
           itraconazole capsule formulations: a comparative analysis

    • Authors: Rajan Verma, Shrikant Hodge, Chandrashekhar Gargote, Prakash Modi, Naresh Upreti, Lokesh Yadav, Raviraj Pillai
      Pages: 765 - 770
      Abstract: Background: This in vitro study compared physical parameters and the dissolution profile of innovator itraconazole capsule formulation, i-Tyza, and 5 other generic capsule formulations available in the Indian market.Methods: The number of pellets and size distribution were determined using naked eye examination and sieving method, respectively. Dissolution profile of formulations was done at 15, 30, 45, and 60 minutes, using a United States Pharmacopeia type II Paddle apparatus in simulated gastric fluid (SGF, pH 1.2) without enzymes, acetate buffer (pH 4.5) with 0.5% sodium lauryl sulfate (SLS), and phosphate buffer (pH 6.8) with 0.5% SLS.Results: All formulations had capsule size 0. Capsule fill weight (~335 to ~510 mg) and total pellet number (127 to 810) varied across formulation, with the innovator brand having the highest number of pellets. Innovator product and i-Tyza had similar fill weight (~460 mg). Pellet size distribution of the innovator product, brand 2, brand 3, and i-Tyza was relatively narrow. In SGF, except brand 1 (84% dissolved) and brand 5 (80% dissolved), all the formulations had near-complete (>85% drug dissolved) or complete dissolution (>90% drug dissolved) at 60 minutes. In acetate buffer, pH 4.5 with 0.5% SLS and phosphate buffer, pH 6.8 with 0.5% SLS, only the innovator product and i-Tyza demonstrated near-complete to complete dissolution at 60 minutes (96% and 90% dissolved).Conclusions: Across all the itraconazole generic formulations evaluated, i-Tyza had comparable physical characteristics and dissolution profile to the innovator product. The in vitro dissolution profile of i-Tyza may indicate adequate in vivo performance.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194665
      Issue No: Vol. 5, No. 4 (2019)
  • Study of cutaneous manifestations in chronic kidney disease patients on
           maintenance hemodialysis at a tertiary care centre

    • Authors: Kirankanth Vudayana, Vidyasagar Korla, Dilipchandra Chintada, Jami Vijaya Shree
      Pages: 771 - 773
      Abstract: Background: Chronic kidney disease (CKD) is a progressive loss of kidney function over a period of months or years through five stages, presents with various cutaneous manifestations regardless of its aetiology. Patients of CKD disease on hemodialysis treatment which prolong the life expectancy and can also produce skin lesions. Skin changes described in patients with chronic renal disease are also found in patients with renal failure undergoing treatment with either peritoneal dialysis or hemodialysis. High percentage of patients receiving dialysis complains of pruritus that may be severe, in some instances the pruritus worsens with dialysis. The aims of the present study were to study the pattern of cutaneous lesions in patients with chronic kidney disease and to determine the incidence of skin manifestations specific to and associated with CKD.Methods: Hundred patients of CKD on MHD with cutaneous manifestations attending skin outpatient department, nephrology out-patient department, dialysis center and patients admitted in medical wards were included in the study.Results: The common cutaneous manifestations were xerosis 91%, pallor 78% and pruritus 69%. Nail manifestations include onycholysis 37% and half and half nails 33%. Hair manifestations in 24% patients.Conclusions: Most common cutaneous manifestation was xerosis, followed by pallor. Most common nail manifestation was onyholysis.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194666
      Issue No: Vol. 5, No. 4 (2019)
  • A study on the dermatology life quality index in patients with acne

    • Authors: Sangaiah Sivaramakrishnan, Thomas Jayakar
      Pages: 774 - 778
      Abstract: Background: Acne vulgaris is a common, chronic disorder, involving inflammation of the pilosebaceous units that can be varied in presentation and difficult to treat. Most adolescents experience some acne; however, it may linger into adulthood. This study was done to evaluate the dermatology life quality index in patients with acne vulgaris.Methods: A cross sectional study was done with pretested Dermatology life quality index (DLQI) questionnaire on 100 acne patients 15 years and above, in a tertiary care hospital. Interpretation of score and impact on quality of life (QoL) was done and graded as no effect, small effect, moderate effect, and very large effect.Results: In our study, females outnumbered males (M: F ratio=1: 1.22). The age group most affected was within 15 and 20 years of age. The mean DLQI score was 5.59±4.07. Most of them had a ‘small impact’ on the QoL. QoL was worse in females. The most common grade of acne overall was grade 2 acne. Grade 3 acne was more common in men. Most of the patients (84%) experienced some degree of embarrassment or increased self-consciousness due to their acne.Conclusions: Our study showed significant impairment of QoL in acne patients. Treatment of acne should not be guided only by the clinical grade of acne, but take into consideration the psychosocial impact the condition has on the patient. Adequate counselling along with early treatment of acne vulgaris is essential in order to reduce the disease-related psychosocial sequelae and increase treatment efficacy.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194667
      Issue No: Vol. 5, No. 4 (2019)
  • Palmoplantar psoriasis: a comparative therapeutic study

    • Authors: Sathya Narayanan Rajendran, Sukanya Mathupal Gurusamy
      Pages: 779 - 783
      Abstract: Background: Psoriasis is an immunologically mediated inflammatory dermatosis presenting with extremely variable clinical manifestations ranging from indolent lesions to life threatening forms of pustular and erythrodermic psoriasis. Palmoplantar psoriasis present as hyperkeratotic scaly plaques with fissures and can be managed with different treatment forms. This study was done to compare the efficacy between topical and systemic treatment options.Methods: The study was conducted in a tertiary level teaching hospital after ethical committee clearance. Fifty patients with palmoplantar psoriasis were allocated into the two groups using simple random sampling. PPPASI scoring was calculated to assess the extent of involvement. Patients in Group A were prescribed calcipotriol with clobetasol propionate ointment. Group B patients were given tablet methotrexate.Results: Twenty eight patients were males M: F of 1.27: 1. Mean age was 36. Mean duration of illness was eleven months. Most of these patients were manual laborers. 32 patients had lesions over both palms and soles, 9 over palms alone and 9 involving soles alone. Mean PASI reduction at 16 weeks was seen maximum with methotrexate. Compliance was comparatively good with methotrexate than topical. Though mean PASI reduction and compliance was good, relapse rates were higher with methotrexate in our study.Conclusions: There was no significant change in clinico-epidemiology and presentation of palmoplantar psoriasis. Methotrexate was observed to be the more efficacious modality in treating palmoplantar psoriasis.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194668
      Issue No: Vol. 5, No. 4 (2019)
  • Overview of axillary dermatoses: case series in a tertiary care

    • Authors: Ramesh A., Sampath V., Kasiviswanathan P., Rajan Babu D.
      Pages: 784 - 791
      Abstract: Background: Axillary dermatoses are common skin disorders in the general population. The objective was to find out the age and sex incidence of various skin dermatoses in the axillae in patients attending the outpatient department of dermatology and to find out the various clinical types of axillary dermatoses.Methods: It was a prospective observational study carried out in a tertiary care hospital, Chennai, Tamil Nadu, India. Patients with skin lesions confined only to the axillae were included in the study thorough history, clinical examination, routine and special investigations like skin biopsy.Results: Out of 76 patients of our study group, the age ranged from 40 days to 59 years; 55 were males, 21 were females and six children with male to female ratio of 1:1. Most commonly affected age group was 30-40 years (25%). Most common axillary dermatoses in this study was tinea axillaris (21.05 %), followed by pityriasis versicolor (19.73%), erythrasma (9.21%), acanthosis nigricans (6.57%), etc.Conclusions: This study highlights awareness and the increasing trend of axillary dermatoses with predominance of male predilection. Early detection and treatment of lesions are crucial to decrease the functional and cosmetic disfigurements especially hidradenitis suppurativa. This study highlights the importance of improving awareness among the general population especially the rampant use of cosmetics. Skin biopsy for diagnosis of neurodegenerative disorder, dermatologists plays a crucial role. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194669
      Issue No: Vol. 5, No. 4 (2019)
  • Efficacy and tolerability of Arnophyte cream for herpes infection, in
           subjects with early signs and symptoms of recurrent HSV-2

    • Authors: Kavita S. Salkar, Chetna S. Chotalia, Rajiv Y. Salvi, Nimesh D. Mehta, Anirudh T. Tripathi
      Pages: 792 - 799
      Abstract: Background: Arnophyte® cream developed from Ficus arnottiana plant extract showed strong potential as an Anti-viral agent. The objective of the study was to evaluate the efficacy and tolerability of Arnophyte® cream in subjects with early signs and symptoms of recurrent HSV-2.Methods: The treatment was given for a period of 14 days. The study outcomes measured were assessment of reduction in pain using the visual analogue score (VAS), the changes in the quality of life index for recurrent genital herpes (GHQoLr); physician’s and patient’s global assessment of the therapy, signs and symptoms associated with HSV-2 and healing of the target lesion on baseline, day 2, day 4, day 7 and day 15.Results: Arnophyte® cream showed significant reduction in the signs and symptoms of herpes infection. The cream was well tolerated with no serious adverse events observed.Conclusions: Arnophyte® cream can be considered as a possible therapeutic option for the treatment of recurrent herpes infections in both HSV-1 and HSV-2.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194670
      Issue No: Vol. 5, No. 4 (2019)
  • Clinico-etiological analysis of annular skin eruptions: a cross-sectional
           study from Western Maharashtra

    • Authors: Waseem Y. Syed, Vasudha A. Belgaumkar, Sandhya A. Garad, Pallavi P. Patil, Nitika S. Deshmukh, Ravindranath B. Chavan
      Pages: 800 - 807
      Abstract: Background: Annular skin eruptions commonly present in dermatology outpatient department. The most common cause of annular lesions encountered among the adult population in developing nations is dermatophytosis. The aim of the study was to identify risk factors and determine etiology of annular skin lesions after correlation of clinical, pathological, serological and mycological features and to analyze the clinical and laboratory features.Methods: A cross-sectional study was conducted on 103 patients presenting with annular skin eruptions to the Dermatology outpatient/inpatient department of BJ Government Medical College and Sassoon Hospital, Pune during a two year period (2015 to 2017).Results: During a two year period from 2015 to 2017, 103 patients with annular skin eruptions were enrolled. Of these, 67% (65.05%) had superficial dermatophytosis while 16 (15.5%) had Hansens disease. Other groups of sporadic cases found were chronic plaque psoriasis (54.85%), pityriasis rosea (43.9%), pityriasis versicolor (21.9%), secondary syphilis (21.9%), granuloma annulare (21.9%), annular elastolytic giant cell granuloma (11%), Bowens disease (11%), erythema multiforme (11%), porokeratosis (11%) and sarcoidosis (11%). Statistically significant association was found between number, color, site and symptoms in superficial dermatophytosis.Conclusions: This was a novel study that attempted a comprehensive clinico-etiological compilation of annular skin eruptions analyzing a large number of clinical variables and risk factors. Based on the observations, an algorithmic clinical approach has been suggested to facilitate early diagnosis and treatment initiation.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194671
      Issue No: Vol. 5, No. 4 (2019)
  • Topical olive oil and narrow band ultraviolet-B trial for segmental
           vitiligo among adult Sudanese patients in Khartoum state, Sudan 2018

    • Authors: Loai Gaffer Ahmed Ali, Al Taieb Mohammed A. Fadul, Mohammed Abdullah M. Taha
      Pages: 808 - 811
      Abstract: Background: Adult segmental vitiligo treated by narrow band ultraviolet B (NB-UVB) showed delayed repigmentation. This study is being undertaken to determine the efficacy of topical olive oil addition before (NB-UVB) sessions for vitiligo patients (pts).Methods: Randomized controlled trial (RCT) enrolled ten volunteers suffering segmental vitiligo on both upper limbs, all patients left limb was tested by topical olive oil before each NB-UVB session and twice daily in session free days for a total of 20 sessions (46 days), the right upper limb was the control (only NB-UVB), each site response was assessed based on time of appearance of erythema and repigmentation. Statistical analysis was done by the Chi-square test.Results: All patients were ten, seven were female (70%), three males (30%) of middle age group, university graduates live in Khartoum state. Their left upper limbs showed erythema in <3 sessions in five pts (50%) and three-five sessions in (50%), repigmentation started in <3 sessions in one patient (10%) and three-four sessions in five pt. (50%) and >5 sessions for four pts (40%), pattern of repigmentation was marginal in eight pts (80%), mixed in two pts (20%). Their right upper limbs showed erythema in three-four sessions in two pts (20%) and eight pts (80%) needed five sessions, repigmentation started after five sessions in all patients (100%), pattern of repigmentation was follicular in one pts (10%), marginal in five pts (50%), mixed in four pts (40%).Conclusions: Addition of topical olive oil to NB-UVB for segmental vitiligo patients showed earlier occurrence of repigmentation and better pigmentation pattern.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194672
      Issue No: Vol. 5, No. 4 (2019)
  • Dermatological life quality index in psoriasis

    • Authors: N. R. Vignesh, Jayakar Thomas
      Pages: 812 - 815
      Abstract: Background: Psoriasis is an immune mediated chronic inflammatory disorder characterized by chronicity of the condition and periods of relapses and remissions. Dermatological life quality index (DLQI) is a widely used measure to determine the patient reported outcome in psoriasis. This study was conducted to evaluate the quality of life in psoriasis patients depending upon their age, sex, type of the disease, duration of the disease and with treatment.Methods: This is a cross sectional study performed in a tertiary care center in Chennai. The study was performed in 100 patients with a prepared DLQI questionnaire. The patients were asked to fill in the questionnaire and the results were graded from mild to very severe.Results: In this study, males outnumbered women in the ratio of 1.2:1. Patients in the age group 41-60 years formed the majority in this study. Itching and soreness of the lesions worsened the DLQI in majority of the patients. Quality of life of patients with psoriasis vulgaris was much affected when compared with other types of psoriasis like erythrodermic and scalp psoriasis. Also, married patients with psoriasis had significant impairment in their quality of life compared to unmarried patients.Conclusions: The findings of this study showed that psoriasis has a significant impairment in the quality of life and hence DLQI should be assessed at the first visit and also after treatment to improve the compliance of the patients towards the doctor as well as to the treatment.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194673
      Issue No: Vol. 5, No. 4 (2019)
  • Clinical spectrum of childhood dermatoses during peak summer in a tertiary
           care centre

    • Authors: Jayanthi Nagappan Subramaniam, Saraswathy Pichaachari, Prithivirajan Balakrishnan
      Pages: 816 - 820
      Abstract: Background: Paediatric dermatoses are very common and may reflect the health and hygiene status of children. The incidence of these skin lesions is widely influenced by seasonal factors. The aim of the study was to study the spectrum of various dermatoses in summer months in children in a tertiary health care centre in north Chennai.Methods: The study included all paediatric cases up to 12 years of age attending the skin OPD of our hospital during the month of May 2018. Total numbers of patients were 975. The patients were divided into 4 categories -infants (< 1 year), toddlers (1-3 years), pre-school children (3-5 years), school going children (5-12 years) as A, B, C and D respectively.Results: Number of children seen in different groups included infants (8.20%), toddlers (23.59%), pre-school children (22.67%), school going children (45.54%) in groups A, B, C and D respectively. The most common skin disease observed comprised of pyoderma (44.18%), followed by miliaria rubra, scabies, dermatophytosis, insect bite allergy, HFMD and others with less than 1% prevalence.Conclusions: The study shows that infections were more common in the paediatric age group in summer, which can provide a suitable environment for the organisms to survive and the infections can be controlled easily by providing proper health care facilities. In order to plan better health care for children, it is mandatory to have a good idea about the existing ailments in the region.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194674
      Issue No: Vol. 5, No. 4 (2019)
  • A clinicopathological study on cutaneous tuberculosis in a tertiary care
           teaching institution

    • Authors: Ramesh A., Sampath V., Deepika S.
      Pages: 821 - 826
      Abstract: Background: Today tuberculosis is known to affect every organ, not forgetting the single largest organ of the body- the skin. The study on cutaneous tuberculosis is conducted with the modest aim of studying its epidemiology, clinical features, immunology, histology and treatment.Methods: Patients with clinical diagnosis of cutaneous tuberculosis were included in study after thorough history, clinical examination, routine and special investigation like AFB staining, Mantoux test and histopathologic studies.Results: Cutaneous tuberculosis constituted 0.11% of total cases. Lupus vulgaris (LV) topped the list followed by tuberculosis verrucosa cutis (TVC) and scrofuloderma (SFD). Commonest age group was in second to third decades. Males outnumbered females. Most of the LV and TVC lesions were confined to the extremities. SFD was confined to head and neck region. BCG vaccination did not confer immunity against cutaneous tuberculosis as observed in this study. HIV positivity was observed in only one patient in this series although this has been described to be associated commonly with cutaneous infections. Histopathological features were consistent with cutaneous TB in all the patients. All these cases responded well to ATT and those cases which could be followed did not show any recurrence.Conclusions: This study highlights the incidence of cutaneous tuberculosis with male predilection. Early detection and treatment of lesions are crucial to decrease functional and cosmetic disfigurement, importance of assessing HIV status in patients with multicentric cutaneous tuberculosis and also this study highlights the importance of improving awareness among general practitioners, public health workers and general population.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194675
      Issue No: Vol. 5, No. 4 (2019)
  • Therapeutic evaluation of intralesional measles, mumps and rubella vaccine
           in palmoplantar warts

    • Authors: Geetha K.
      Pages: 827 - 830
      Abstract: Background: Warts are common viral infections of the skin caused by human papilloma virus. Most of the treatment modalities for common warts remain unsatisfactory. Immunotherapy has become one of the important therapeutic modality. This study was conducted to evaluate the efficacy of intralesional measles, mumps and rubella (MMR) vaccine immunotherapy in palmoplantar warts.Methods: 60 patients of various age groups and both sexes who have single or multiple palmoplantar warts not on any other concurrent systemic or topical therapy were randomly included for the study. Patients with other types of warts, signs of other infection, pregnancy, lactation and immunosuppression were excluded from the study. MMR Vaccine was injected intralesionally at 2 week intervals until complete clearance or for a maximum of 3 treatments. The outcome in terms of treatment relapse, recurrences and adverse effects were evaluated.Results: Only 54 patients completed the study and 41 (75.9%) of them showed complete response and 13 (24%) of them showed partial or no response.Conclusions: Intralesional MMR vaccine therapy appears to be a safe and effective treatment option with no significant adverse effects and low recurrence.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194676
      Issue No: Vol. 5, No. 4 (2019)
  • Evaluation of adapalene alone versus combination therapy of adapalene with
           benzoyl peroxide and adapalene with clindamycin in treatment of acne
           vulgaris: a prospective, observational study

    • Authors: Nehal R. Parikh, Shikha V. Sood, Devang Rana, Raju Chaudhary, Supriya D. Malhotra
      Pages: 831 - 838
      Abstract: Background: Acne vulgaris is majorly affecting adolescent population with profound negative impact on the quality of life (QOL). The objectives of the present study was to evaluate adapalene 0.1% alone vs combination therapy of adapalene 0.1% with benzoyl peroxide (BPO) 2.5% and adapalene 0.1% with clindamycin 1% in the treatment of acne vulgaris and to analyse health related QOL using the cardiff acne disability index (CADI).Methods: This prospective, observational study of 12 months duration involved patients who were being treated with adapalene alone and adapalene combined with either clindamycin or benzoyl peroxide in the normal course of treatment. Efficacy of treatment and QOL was assessed by the comprehensive acne severity system (CASS) and CADI respectively.Results: A total of 180 patients were enrolled (n=60 in each group). Male: female ratio was 1: 2.52. 76.7% patients were of adolescent age with the Mean age of 21.17±3.28 years. Average age of onset was 18.03±2.80 years. Most patients had moderate grade of acne (51%) followed by mild grade (46%) and almost clear (3%). Face was the common site, followed by back and chest. There was a statistically significant improvement in both number of lesions and also QOL in all the three treatment groups (p<0.0001).Conclusions: Topical adapalene 0.1% is efficacious in the treatment of acne vulgaris both alone as well as in combination with topical benzoyl peroxide 2.5% and topical clindamycin 1%. Adapalene also has positive influence on the QOL alone as well as in combination but no superiority of one group over the other was observed with regard to efficacy as well as QOL. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194677
      Issue No: Vol. 5, No. 4 (2019)
  • A study on cutaneous adverse drug reactions in a tertiary care center in
           Rajnandgaon, Chattisgarh

    • Authors: Pooja Pandey, Prabhat Pandey, Sharad Manore, Darshan Sandesara
      Pages: 839 - 843
      Abstract: Background: Cutaneous reactions are one of the most common types of adverse drug reactions which may vary from mildly discomforting to those that are life-threatening.Methods: This prospective, observational study was done in the department of dermatology. Patients with suspected drug rash, of either sex or all age groups were included in the study.Results: A total of 114 patients were enrolled in the study. The most common presenting symptoms of cutaneous adverse drug reactions (CADRs) were itching, burning sensation and pigmentation with 61.31%, 13.87% and 10.22% respectively. A total of 21 different CADRs were observed. The common causative agents were of anti-microbial, nervous system and musculoskeletal class in both outdoor and indoor patients with 51 (37.22%), 21 (15.32%) and 25 (18.24%) respectively.Conclusions: The most common CADR observed in the study was antimicrobials and NSAIDs were the most common causative drugs. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194678
      Issue No: Vol. 5, No. 4 (2019)
  • Topical steroid addiction among paramedical staff: a cross sectional study
           in a tertiary health care centre

    • Authors: Maitreyee Panda, Ipsita Debata, Debasmita Behera, Chinmoy Raj, Ajaya Jena
      Pages: 844 - 848
      Abstract: Background: Topical corticosteroid misuse is one of the major causes of concern for dermatologist now-a-days. It is not only prevalent in general population but also among individuals associated with medical profession like paramedical staffs. The aim of the present study was to understand the various causes and demographic profile of paramedical staffs using steroids alone or in combination as fairness creams.Methods: All paramedical staffs using topical steroids as fairness creams were screened for the exclusion criteria and included in our study.Results: Females staffs (82.24%) predominated our study group. Betamethasone valerate (46.16%) was found to be the most common topical corticosteroid being misused and the source of recommendation was mostly from pharmacy (37.06%) without any prescriptions.Conclusions: With increasing misuse of topical corticosteroids it is the need of the hour to evaluate the intensity of the problem, contributing factors and the associated morbidity leading to impaired quality of life, not only in the general population but also among the health care provider.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194679
      Issue No: Vol. 5, No. 4 (2019)
  • Clinical study of herpes zoster in 109 patients in central referral
           hospital, Gangtok

    • Authors: Rukma L. Sharma, Rekha Sharma
      Pages: 849 - 852
      Abstract: Background: Herpes zoster results from the reactivation of varicella-zoster virus lying dormant in the dorsal root ganglia following an earlier primary infection (chickenpox), usually in childhood. The reactivation occurs due to multifactorial causes leading to decreased immunity.Methods: This study was conducted on 109 cases of herpes zoster. Patient’s particulars were noted. A detailed history was recorded; morphology, the site and side of skin lesions were recorded. Any other associated diseases were noted.Results: Out of 109 patients 66 were male and 43 were female. The total of 53 (48.6%) patients were under the age of 40 years and 56 (51.4%) patients above 40 years. Bhutias were affected in highest number (18.4%) followed by Sharma community (15.6%). The ophthalmic division of trigeminal nerve was the most commonly affected single nerve with 13.8% followed by T10 and T7 dermatome at 9.17% and 7.3% respectively. Thoracic nerves the most commonly involved thoracic nerves with 44 cases. Single dermatomal eruptions were found in 55 patients. The dissemination of herpes zoster was although very rare but was present in three patients. Type 2 diabetes mellitus was the common associated systemic illness with 10.09% of patients.Conclusions: From this study it was revealed that both young adults and older age group people were affected almost equally. The male: female ratio was 1.5:1 with Bhutia community being mostly affected. Thoracic dermatome was the most common dermatome involved and in half the patients some form of associated disease noted.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194680
      Issue No: Vol. 5, No. 4 (2019)
  • Treatment outcome of acne vulgaris with topical application of clindamycin
           gel and benzoyl peroxide gel as supplementary files

    • Authors: Devendra Parmar, Dhairya Salvi
      Pages: 853 - 856
      Abstract: Background: Acne vulgaris is one of the commonest inflammatory skin disorders. It also has a psychosocial impact on patients, specially known in adolescents and hence needs effective treatment. The objectives of the study was to find out and ascertain different clinical presentations of acne vulgaris in both sexes of various age groups and to find out the outcome of treatment with various topical modalities in various clinical types.Methods: A total of 150 patients with acne vulgaris were studied with age group >10 years. Detailed history, thorough physical examination and relevant investigations were done. Patients were divided into 2 groups of 75 each and each group received different treatment and were followed up at 4th, 8th and 12th week.Results: At the end of 12 weeks there was significant improvement in grade-II patients treated with cindamycin 1% gel.Conclusions: The results of the study show that different grades of acne vulgaris respond with different regimens. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194681
      Issue No: Vol. 5, No. 4 (2019)
  • Role of dual energy X-ray absorptiometry scan for assessing bone mineral
           density in patients with chronic plaque psoriasis: a cross-sectional study

    • Authors: Revathi T. N., Maheshwari Sajjanshetty
      Pages: 857 - 860
      Abstract: Background: Psoriasis is a T cell mediated chronic inflammatory disorder of skin, joints and immune system. Data regarding possible association between psoriasis and reduced bone mineral density are limited and hence association is not fully conclusive. Systemic inflammatory cytokines in the psoriasis have been identified in the pathogenesis of reduced bone mineral density. Among various available methods, Dual X-ray absorptiometry (DXA), found to be gold standard for assessing bone mineral density.Methods: An observation study of 30 patients with chronic plaque psoriasis aged between 18 years to 50 years fulfilling the criteria were enrolled and studied. Dual energy X-ray absorptiometry scan (DEXA) of left forearm radius (non-dominant hand) was done. T score was calculated and bone mineral density assessed based on WHO criteria. Using software SPSS version 24, Pearson’s correlation and linear regression analysis applied.Results: Out of 30 patients, there were 18 males and 12 females. Mean age of patients 37.93 years. Majority of the psoriatic patient showed osteopenia on DEXA scan and significant positive correlation was found between duration of psoriasis disease (r=0.34, p=0.03), body surface area percentage (r=0.36, p=0.04) and body mass index (r=0.32, p=0.02).Conclusions: Early identification of reduced bone mineral density in patients with psoriasis particularly in those with longer duration of the disease, involving large body surface area (more than 10) and with higher body mass index by DEXA scan helps to reduce osteoporotic fracture and other associated comorbidities.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194682
      Issue No: Vol. 5, No. 4 (2019)
  • Role of different topical modalities in improvement of facial
           hyperpigmentation and skin rejuvenation

    • Authors: Kunwar Manoj Kumar, Amit Kumar Pandey, Aayushi Mohan, Surya Kant Ojha
      Pages: 861 - 869
      Abstract: Background: Facial hypermelanosis is a psychologically stressful condition for modern men and women who are cosmetically more conscious than their ancestors. There are various lightening agent used for several months before effect becomes apparent and are much more effective when pigment is epidermal. these topical agents include hydroquinone, liquorice derivatives niacinamide, glycolic acid, arbutin and deoxyarbutin, ascorbic acid, 4-n-butyl resorcinol, retinoids topical steroids mequinol, kojic acid, azelaic acid, 5% tranexmic acid, glutathione cream etc.Methods: A randomized, controlled study was done. 220 patients were given either treatment will be given depending upon the physician choice after taking well informed consent from the patient. Patients' assessment regarding the degree of improvement of complexion since the beginning of therapy was evaluated.Results: The percentage satisfactory response for different modalities was as follow kojic acid 2% cream- 55.55%, 20% azelaic acid cream- 53.12%, 4-n-butyl resorcinol 0.3% cream- 57.89%, 5% tranexmic acid lotion- 48.83% and glutathione cream- 55.76%.Conclusions: Out 220 patients post inflammatory hyperpigmentation was the most common facial condition. Total 61 patients of PIH were there in the present study including 26 males and 35 females followed by melasma. All The modalities were effective in the treatment of different types- pigmentary conditions. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194683
      Issue No: Vol. 5, No. 4 (2019)
  • A clinico pathological correlation in leprosy in a tertiary care teaching

    • Authors: Ramesh A., Sampath V., Shvedha M.
      Pages: 870 - 874
      Abstract: Background: Leprosy is a chronic infectious granulomatous disease caused by Mycobacterium leprae. The disease primarily affects peripheral nervous system, the skin and certain other tissues. It is a spectral disease which is classified into five groups based on clinical, histopathological and bacteriological and immunological criteria as tuberculoid (TT), borderline tuberculoid (BT), mid-borderline (BB), borderline lepromatous (BL), lepromatous (LL) according to Ridley-Jopling classification. Adequate clinical information combined with histopathology and bacteriological index is helpful not only in classification of different types of leprosy, but also useful for management of cases.The objective of the study was to correlate clinical diagnosis with histopathological findings of leprosy.Methods: A retrospective study was conducted for one year from January to December 2018 in Leprosy clinic, Department of Dermatology, Rajiv Gandhi Government General Hospital and Madras Medical College, Chennai. The histopathological findings were compared with clinical diagnosis.Results: A total number of cases attended leprosy clinic from January 2018 to December 2018 was 167 cases, among those 49 clinically diagnosed cases were included in the study. Out of 49 cases, maximum number of patients belonged to 30-50 years age group. Male to female ratio was 3.9: 1. Hypopigmented, hypoaesthetic patches were commonly seen. Clinically as well as histopathologically BT leprosy was common.The maximum histological correlation seen in lepromatous leprosy (100%) followed by BT (80%).Conclusions: The study emphasises the role of skin biopsy in confirming the clinical diagnosis of leprosy and also as a therapeutic guide.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194684
      Issue No: Vol. 5, No. 4 (2019)
  • An observational study on papules over the face in elderly women above the
           age of fifty years

    • Authors: Vipul Paul Thomas, Jayakar Thomas
      Pages: 875 - 878
      Abstract: Background: Facial papules over the face occurring in women above fifty years can be of multiple aetiologies like infections, inflammatory causes and tumours either benign or malignant. Diagnosis is mainly clinical and histopathology only for conformation.Methods: A cross sectional study was done to evaluate the incidence of papules in women attending the dermatology OPD in a tertiary care hospital aged above 50 years of age. Interpretation of the findings included the frequency of various benign and malignant conditions and also if the papules where the reason for the consultation.Results: In our study majority of the patients had asymptomatic facial papules and had come to the dermatology OPD for other skin conditions. The most common cause for facial papules was compound nevus followed by dermatitis papulosa nigra. The age group most affected was within 61and 70 years of age.Conclusions: Our study concluded that facial papules of benign neoplastic aetiology are the most prevalent in our population setting. Treatment is advised for symptomatic relief, cosmetic amelioration or malignancy prophylaxis. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194685
      Issue No: Vol. 5, No. 4 (2019)
  • Bleomycin-induced flagellate pigmentation: a case report from North-East

    • Authors: Nandakishore Thokchom, Nandita Bhattacharjee, Linda Kongbam
      Pages: 879 - 881
      Abstract: Bleomycin is an antitumour antibiotic commonly used in the management of Hodgkin’s lymphoma and germ cell tumours. Flagellate pigmentation is a very specific and rare cutaneous adverse effect of bleomycin. It is characterised by linear, painless, pruritic, hyperpigmented lesions simulating marks of whiplashes over trunk and extremities. With the advent of targeted therapies resulting in the infrequent use of bleomycin, this unique side effect is also uncommonly encountered nowadays. Here, we report a case of bleomycin-induced flagellate pigmentation in a 35-year-old Indian female with ovarian teratoma. The characteristic patterned hyperpigmented patches developed following 2nd cycle of chemotherapy with bleomycin, etoposide and cisplatin. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194686
      Issue No: Vol. 5, No. 4 (2019)
  • Vitiligo following alemtuzumab therapy in multiple sclerosis: a
           demonstration of secondary autoimmunity

    • Authors: Jennifer Seyffert, William Steffes
      Pages: 882 - 884
      Abstract: Secondary autoimmunity is the most frequent adverse event that occurs in Relapsing and remitting multiple sclerosis (RRMS) patients who are being treated with alemtuzumab, however there have been few reported cases of autoimmune dermatologic conditions associated with alemtuzumab therapy. We report a case of a patient with RRMS who presented with depigmentation of the right lower cutaneous lip, consistent with vitiligo, seven months after her second treatment cycle with alemtuzumab. We emphasize the need for careful clinical surveillance of patients undergoing alemtuzumab therapy for rarely described secondary cutaneous autoimmune diseases.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194687
      Issue No: Vol. 5, No. 4 (2019)
  • Case report of primary cutaneous anaplastic large cell lymphoma of adult
           female patient visiting dermatology clinic of King Abdul-Aziz Medical
           City, National Guard Health Affairs, Jeddah, Saudi Arabia, 2018

    • Authors: Hani Saad Al-Mugti, Ola Yaseen Samman
      Pages: 885 - 888
      Abstract: Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare T-cell cutaneous lymphoma consisting of CD30 positive typically anaplastic-appearing cells. PCALCL had been distinguished from systemic anaplastic large cell lymphoma (ALCL) and lymphomatous papulosis by World Health Organization classification of lymphoid neoplasms. Previous studies have shown PCALCL has an excellent overall survival with few patients dying from disease. This is a case report study design with detailed history, examination of 54-years-old female patient with a painful nodular lesion in the left thigh, which is misdiagnosed as Pyoderma Gangrenosum.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194688
      Issue No: Vol. 5, No. 4 (2019)
  • Topical corticosteroids induced hyper-pigmentation: a case report

    • Authors: Bhawna Saini, Mohit Kumar, Arkapal Bandyopadhyay
      Pages: 889 - 893
      Abstract: Hyper-pigmentation is a common skin condition in which increased melanin production results in darker patches of skin. Although hyper-pigmentation is harmless but still mostly people wish to get rid of them because of increasing craze of beautification in India. Topical corticosteroids (TC) application showed quick amelioration of post-inflammatory hyper-pigmentation patches. Prolonged and unsupervised use of TC leads to skin atrophy and reappearance of hyper-pigmentation patches. We present two cases of hyper-pigmentation induced by TC misuse. In case-1, a 20 year old female came to OPD with a complaint of hyper-pigmentation and itch sensation along with drug history of Betnovate cream for the last 2 years for acne treatment. On examination, she showed signs of hyper-pigmentation on cheeks. She was counselled to stop the further use of Betnovate cream and prescribed demelanizing agents along with sunscreen and emollients. The patches improved significantly with above management within 15 days. In case-2, a 33 year old female came to OPD with complaints of redness over whole face, increased facial hair growth and burning sensation along with drug history of using Betnovate cream for 2 years. On examination she showed signs of hyper-pigmentation and redness on cheeks, bruise and tearing of skin and increased facial hair growth. She was counselled to stop the further use of Betnovate cream. She was prescribed retinoic acid cream, sunscreen agents, anti-allergic tablets and emollient cream. The patches improved significantly with above management within 15 days. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194689
      Issue No: Vol. 5, No. 4 (2019)
  • Peeling skin syndrome: an investigational dilemma

    • Authors: Shefali Saini, Vidya Kharkar
      Pages: 894 - 897
      Abstract: Peeling skin syndrome  is a rare autosomal recessive disorder of cornification that starts either at birth or later in childhood, characterized by widespread painless peeling of the skin in superficial sheets. We report the case of a 13-year-old boy who presented with asymptomatic peeling of skin since birth. Sheets of skin were peeling from the neck, trunk and extremities following mild friction or rubbing, with sparing of palms and soles. The case is being reported due to its rarity.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194690
      Issue No: Vol. 5, No. 4 (2019)
  • Scar sarcoidosis: additional involvement of de novo sites and update on

    • Authors: Vasudha A. Belgaumkar, Ravindranath B. Chavan, Prernaa R. Suryataley, Pallavi P. Patil, Vijay V. Raut
      Pages: 898 - 900
      Abstract: Cutaneous sarcoidosis is an immune-mediated multisystem granulomatous inflammatory disease of unknown etiology. Noncaseating granuloma in pre-existing scars is an uncommon but specific cutaneous manifestation of sarcoidosis. This great imitator may be an under-diagnosed disease in developing countries like India probably because of the diverse range of clinical presentations. Herein we present a 45-year old female with cutaneous sarcoidosis involving scars in addition to de-novo sites.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194691
      Issue No: Vol. 5, No. 4 (2019)
  • Bilaterally occurring lipogranuloma affecting the periorbital regions

    • Authors: Vipul Paul Thomas, Sivaramakrishnan S., Jayakar Thomas
      Pages: 901 - 903
      Abstract: Lipogranulomas are the result of an uncommon inflammatory reaction occurring in the dermis due to exogenous or endogenous lipids. Lipogranulomas present as asymptomatic swellings usually at the site of trauma or medical intervention. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194692
      Issue No: Vol. 5, No. 4 (2019)
  • Eruptive syringoma: a case report

    • Authors: Siddhartha S. Saikia, Ashish G. Jagati, Santoshdev P. Rathod, Raju G. Chaudhary
      Pages: 904 - 906
      Abstract: Eruptive syringoma is a rare clinical presentation of a benign tumor of the eccrine ducts. Its usual presentation is small, smooth, skin coloured papules with flattened or rounded tops on the anterior body surfaces including face. It usually affects adult female. Treatment of this benign condition is cosmetic only. Herein, we report an uncommon presentation in a 30 years old female who presented with multiple, asymptomatic, skin coloured papules over face, neck, chest and thighs. Histopathology showed collection of cystic ducts and epithelial cords with comma like tails in dermis confirming a diagnosis of eruptive syringomas. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194693
      Issue No: Vol. 5, No. 4 (2019)
  • A not so common cause for fever with rashes

    • Authors: Murali Narasimhan, Saju A. Sathar, Ramachandran Ramakrishnan
      Pages: 907 - 909
      Abstract: Skin rashes that appear during febrile illnesses can be due to various infectious diseases and non-infectious conditions that can range from mild self-limiting diseases to potentially life threatening conditions. Hence a comprehensive knowledge of these diseases is required. A comprehensive history must be taken, including intake of any medications, contact with animals, recent travel, and trekking in various natural environments. Complete and thorough physical examination can provide clues to early diagnosis. Here we report a case which presented with high grade fever, generalized blanching maculopapular rashes, and headache. Close examination revealed a scrotal ulcer leading to the diagnosis of scrub typhus which was confirmed by ELISA and treated successfully with doxycycline. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194694
      Issue No: Vol. 5, No. 4 (2019)
  • A case of CD20 positive peripheral T-cell lymphoma: not otherwise
           specified masquerading as botryomycosis

    • Authors: Amruthavalli Potlapati, Neethu Mary George, Narendra Gangaiah, Veena Thimmappa
      Pages: 910 - 913
      Abstract: Peripheral T-cell lymphoma (PTCL), a type of non-Hodgkin’s lymphoma, is an uncommon malignancy frequently involving the skin either as primary or secondary manifestation of the disease. Lymphomas may occasionally masquerade as infectious diseases especially when it is not associated with significant lymphadenopathy. Botryomycosis is a chronic granulomatous suppurative bacterial infection, predominantly caused by Staphylococcus aureus, which is seen on trauma prone sites. Herein we present a case of a 33 years old male who presented to us with multiple rapidly growing friable masses on the chest wall of six weeks duration which clinically pointed towards botryomycosis. Lack of response to treatment with intravenous antibiotics and absence of grains and granuloma in the biopsy specimen made us further proceed for immune-histochemical evaluation which confirmed a rare type of CD20 positive PTCL. In conclusion, our case alerts physician to maintain a high index of suspicion for unusual entities in cases they encounter, cases with unusual presentation or atypical response to treatment.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194695
      Issue No: Vol. 5, No. 4 (2019)
  • Cutaneous sarcoidosis: a case report from North-East India

    • Authors: Nandakishore Thokchom, Linda Kongbam, Nandita Bhattacharjee
      Pages: 914 - 916
      Abstract: Sarcoidosis is a multisystem granulomatous disease of unknown aetiology. Cutaneous sarcoidosis is seen in up to one-third of patients and may be the first or the only clinical sign of the disease. We report a case of cutaneous sarcoidosis with lungs and renal involvement in a 28-year-old housewife. She presented with itchy reddish-brown indurated plaques on left cheek and back for 2 years. Skin biopsy revealed non-caseating epithelioid granulomas. Contrast enhanced computed tomography thorax showed focal consolidation and multiple enlarged mediastinal lymph nodes and serum angiotensin-converting enzyme level was raised. Since cutaneous manifestations of sarcoidosis are extremely variable, its early recognition can provide a clue to the diagnosis and its systemic involvement. 
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194696
      Issue No: Vol. 5, No. 4 (2019)
  • Biologics in dermatology

    • Authors: Abhishek D. Oka, Tanvi P. Vaidya, Prashant Potdar
      Pages: 917 - 926
      Abstract: The role of biologicals in dermatology has seen an exponential growth in the last few years. Biologicals such as TNF-alpha inhibitors have now lost their novelty and are routinely used all over the world. As the pathogenesis of various diseases is now being understood better, we have been able to create more targeted biological therapies for a number of dermatological conditions. We attempt to compile an update on the newer biologicals in use today, and briefly touch upon the older ones as well. We conducted an extensive literature search and have covered TNF-alpha inhibitors, molecules against T cell receptors, Janus Kinase inhibitors, interleukin based molecules, fusion proteins, and some newer biologicals as well. Their mechanisms of action, indications and dosage have been covered in our review.
      PubDate: 2019-10-21
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20194697
      Issue No: Vol. 5, No. 4 (2019)
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