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Publisher: Medip Academy   (Total: 12 journals)   [Sort by number of followers]

Showing 1 - 12 of 12 Journals sorted alphabetically
Intl. J. of Advances in Medicine     Open Access   (Followers: 1)
Intl. J. of Basic & Clinical Pharmacology     Open Access   (Followers: 2)
Intl. J. of Clinical Trials     Open Access   (Followers: 2)
Intl. J. of Community Medicine and Public Health     Open Access   (Followers: 5)
Intl. J. of Contemporary Pediatrics     Open Access   (Followers: 3)
Intl. J. of Otorhinolaryngology and Head and Neck Surgery     Open Access  
Intl. J. of Reproduction, Contraception, Obstetrics and Gynecology     Open Access   (Followers: 12)
Intl. J. of Research in Dermatology     Open Access   (Followers: 1)
Intl. J. of Research in Medical Sciences     Open Access   (Followers: 4)
Intl. J. of Research in Orthopaedics     Open Access  
Intl. J. of Scientific Reports     Open Access   (Followers: 1)
Intl. Surgery J.     Open Access   (Followers: 1)
Journal Cover International Journal of Scientific Reports
  [1 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2454-2156 - ISSN (Online) 2454-2164
   Published by Medip Academy Homepage  [12 journals]
  • Overview of post marketing aggregate reports and global regulatory
           requirements

    • Authors: Paramaguru Rathinavelsamy
      Pages: 300 - 310
      Abstract: Pharmacovigilance is the science that deals with the activities related to the detection, assessment, understanding, and prevention of ADRs. The scope of pharmacovigilance has evolved over time. We now recognize the importance of a systematic approach for monitoring and improving the safe use of medicines. At the level of individual case safety reports, it is not possible for marketing authorization holders (MAH) to evaluate benefit/risk ratio profile and understand the detailed safety feature of a medicinal product. In addition to submission of individual case safety reports MAH also review periodically, cumulative safety information attained from various sources and submit the findings as aggregate reports to drug regulators. Aggregate reporting is a vital tool to study benefit/risk balance of a medicinal product throughout the product’s life cycle. The timelines, frequency and exact type of aggregate report required to be submitted for the approved product varies globally amongst various drug regulatory agencies. In this review the significance, background, objectives, scope, structural components, timelines for regulatory submissions of post marketing aggregate reports viz. PSUR, PBRER, and PADER have been discussed.
      PubDate: 2017-11-24
      Issue No: Vol. 3, No. 12 (2017)
       
  • Study of utilisation trends of drugs in patients admitted with
           cardiovascular diseases at a tertiary care hospital in Goa

    • Authors: Shantadurga S. Kerkar, Padma N. Bhandare
      Pages: 311 - 317
      Abstract: Background: CVDs have emerged as a leading cause of mortality and morbidity in the world as well as in India. Drug usage is life saving and at times many drugs may be needed. Drug utilization studies aid to find the appropriateness of treatment, identify shortcomings if any, and provide a feedback to the healthcare providers to improve their management with drugs. So such types of studies are of vital importance in every hospital.Methods: This was a prospective, observational study of 180 patients with CVDs admitted in medicine and cardiology wards of a tertiary care hospital, conducted through case records and patients’ interviews. Data was represented as mean±SD, number and frequency.  Results: Incidence of cardiovascular diseases was more in males (56.67%) than the females (43.33%). Average number of drugs prescribed per patient was 9.16 and that of cardiovascular drugs was 5.08 ± 2.15. Antiplatelets (88.88%) were the most commonly prescribed cardiovascular drugs followed by hypolipidemics (82.22%). About 15.06% of injectables and 1.2% of fixed dose combinations (FDCs) were prescribed. Drugs prescribed by generic names were 1.6% and those from the National List of Essential Medicines were 92.79%.Conclusions: The results of this study suggested: polypharmacy, overuse of injections and low prescribing habits from essential drug list. Though antiplatelet, hypolipidemic use was higher, these are an essential part of treatment of certain CVDs. 
      PubDate: 2017-11-24
      Issue No: Vol. 3, No. 12 (2017)
       
  • Brakes on the accelerator: the journey of accelerator hypothesis from
           “the missing link” to “an evolving concept”

    • Authors: Devi Dayal, Balasubramaniyan Muthuvel
      Pages: 318 - 321
      Abstract: The incidence of Type 1 diabetes (T1D) has increased significantly over the past few decades but the causes for this increase are poorly understood and hence the strategies for preventing T1D are difficult to design. T1D is characterised by autoimmune destruction of pancreatic β-cells resulting in insulin deficiency as opposed to Type 2 diabetes (T2D) characterised by weight driven insulin resistance (IR). The accelerator hypothesis (AH), proposed by the late Prof Terence Wilkin in 2001 offers an alternative mechanism for T1D and a different approach to prevention of T1D. This hypothesis considers both T1D and T2D as one and proposes that obesity driven IR is the key factor that may lead to either type of diabetes. It thus offers an easy explanation for the increasing worldwide incidence of childhood diabetes which is paralleled by the increase in childhood obesity rates. However, one of the key predictions of AH that the obesity related IR accelerates the onset of diabetes and hence heavier children should develop diabetes at a younger age, has remained a matter of debate since the hypothesis was first proposed. Since the inception of AH, the results of a number of studies which aimed at testing the hypothesis in diverse patient populations have shown support or opposed this key prediction. This article discusses the relevance of AH in the context of data from these studies.
      PubDate: 2017-11-24
      Issue No: Vol. 3, No. 12 (2017)
       
  • Papillary mucous cystadenoma of parotid gland

    • Authors: Ananthaneni Anuradha, Undavalli Suresh Babu, Penumala Vignatha, Bagalad S. Bhavana
      Pages: 322 - 325
      Abstract: Cystadenomas are rare benign salivary gland tumours characterised by prominent epithelium-lined papillary projections into the cystic spaces. Cystadenoma accounts for 2% of all salivary gland tumors, occurring most commonly in major salivary glands. Histopathologically there are two variants, papillary and mucinous variant. However very few cases are being reported in literature. We report a case of papillary cystadenoma occuring in parotid gland in a 28 year old male patient. Clinically, it presents as a soft, fluctuant, sessile and non-tender swelling measuring about 4×3.5 cm in diameter. Excisional biopsy was performed. The histopathological features were characteristic of papillary cystadenoma. This article highlights its clinical and histopathological features along with review of literature. 
      PubDate: 2017-11-24
      Issue No: Vol. 3, No. 12 (2017)
       
  • Black dog: the future pandemic'

    • Authors: Muthukumar T., Raja T. K.
      Pages: 326 - 326
      Abstract: Depression is sometimes referred to as the “Black Dog”. Just like a real dog, it needs to be embraced, understood, taught new tricks, and ultimately brought to heel. Depression is a common illness worldwide, with more than 300 million people affected; it is different from usual mood fluctuations and short-lived emotional responses to challenges in everyday life. It can cause the affected person to suffer greatly and function poorly at work, at school and in the family. At its worst, depression can lead to suicide. Depression is the leading cause of ill health and disability worldwide. An increase of more than 18% between 2005 and 2015 makes depression a real global threat.
      PubDate: 2017-11-24
      Issue No: Vol. 3, No. 12 (2017)
       
 
 
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