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Publisher: Medip Academy   (Total: 12 journals)   [Sort by number of followers]

Showing 1 - 12 of 12 Journals sorted alphabetically
Intl. J. of Advances in Medicine     Open Access   (Followers: 2)
Intl. J. of Basic & Clinical Pharmacology     Open Access   (Followers: 3)
Intl. J. of Clinical Trials     Open Access   (Followers: 2)
Intl. J. of Community Medicine and Public Health     Open Access   (Followers: 5)
Intl. J. of Contemporary Pediatrics     Open Access   (Followers: 4)
Intl. J. of Otorhinolaryngology and Head and Neck Surgery     Open Access  
Intl. J. of Reproduction, Contraception, Obstetrics and Gynecology     Open Access   (Followers: 12)
Intl. J. of Research in Dermatology     Open Access   (Followers: 1)
Intl. J. of Research in Medical Sciences     Open Access   (Followers: 5)
Intl. J. of Research in Orthopaedics     Open Access  
Intl. J. of Scientific Reports     Open Access   (Followers: 2)
Intl. Surgery J.     Open Access   (Followers: 1)
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International Journal of Clinical Trials
Number of Followers: 2  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2349-3240 - ISSN (Online) 2349-3259
Published by Medip Academy Homepage  [12 journals]
  • Success rate of electromagnetic navigation system on ventriculo-peritoneal
           shunt versus standard shunt placement in patients with hydrocephalus

    • Authors: Aamir Dawood, Muhammad Yasir
      Pages: 33 - 38
      Abstract: Background: Accuracy of ventriculoperitoneal shunt with the development of frameless neuronavigation in the field neurosurgery has been validated in different parts of the world. The objective of this study was to compare the success of electromagnetic (EM) navigation system on ventriculoperitoneal (VP) shunt versus standard shunt placement in patients with hydrocephalus.Methods: This randomized controlled trial was carried out in the Department of Neurosurgery, Multan. This study was approved by the Ethical Review Committee of Nishtar Hospital Multan. Study subjects were selected after an informed consent. Patients were grouped as (A) who received EM and (B) who received routine shunt surgery. Patients with shunts were followed up at the end of 3 months and post-operative CT was performed at the end of 3 months. Both groups were compared in terms of success by using chi-square test.Results: Among 100 study cases, mean GCS was 12.30±1.85 (with minimum GCS was 9 while maximum was 15) and mean duration of hydrocephalus was noted to be 6.80±2.02 weeks. Forty five (45%) were presented with mild hydrocephalus while 55 (55%) presented with moderate hydrocephalus. Grade outcome (post-operative) was noted in 78 (78%) of our study cases, grade 2 in 18 (18%) while grade 3 (failure) was noted in only 4 (4%).Conclusions: The usage of electromagnetic (EM) navigation on ventriculoperitoneal (VP) shunt is safe and reliable which is beneficial for optimal positioning and trajectory of ventricular catheters in adult patients with hydrocephalus. 
      PubDate: 2019-04-29
      DOI: 10.18203/2349-3259.ijct20190968
      Issue No: Vol. 6, No. 2 (2019)
       
  • Patients experiences on the use of dihydroartemisinin piperaquine as an
           alternative first line artemisinin-based combination treatment for
           uncomplicated malaria in Northern Ghana

    • Authors: Samuel Chatio, Philip B. Adongo, Philip A. Dalinjong, Maxwell A. Dalaba, Paula Beeri, Patricia Akweongo, Abraham Oduro
      Pages: 39 - 44
      Abstract: Background: Three different artemisinin-based combination therapies (ACTs) namely; artesunate-amodiaquine, artemether-lumefantrine and dihydroartemisinin-piperaquine (being the latest to be introduced) are concurrently being used for the treatment of falciparum malaria in Ghana. This study assessed patients’ experience, perceptions and willingness to use dihydroartemisinin-piperaquine, brand name duo-cotecxin as an alternative first line ACT for the treatment of falciparum malaria in Northern Ghana.Methods: This was a qualitative study using phenomenology approach where sixty in-depth interviews were conducted with two groups; thirty patients who were given duo-cotecxin, one group and thirty interviews with patients who were given other ACTs (artesunate-amodiaquine, artemether-lumefantrine) as another group. The interviews were conducted between August and November, 2015 Purposive sampling technique was used to select study participants. The interviews were transcribed and coded into themes using QSR NVivo 11 software for thematic content analysis.Results: All patients who used duo-cotecxin reported that the drug was very good in treating uncomplicated malaria compared to other ACTs they had used in the past. Some of the patients who used other ACTs could not complete their doses because of the side effects. However, none of the patients who used duo-cotecxin reported side effects. The findings revealed high acceptance and preference to use duo-cotecxin to treat uncomplicated malaria compared with other ACTs. All the participants were also willing to recommend duo-cotexcin to their relatives and friends to use.Conclusions: Duo-cotecxin as an alternative first line ACT for treatment of uncomplicated malaria is highly accepted, preferred and there was willingness to use it compared with other first line recommended ACTs.
      PubDate: 2019-04-29
      DOI: 10.18203/2349-3259.ijct20191988
      Issue No: Vol. 6, No. 2 (2019)
       
  • Benzodiazepine premedication in general anaesthesia: a clinical
           comparative study

    • Authors: Babita Lahkar, Kalpajit Dutta
      Pages: 45 - 51
      Abstract: Background: The main aims of pre-anaesthetic medication are anxiolysis, analgesia, anti-emesis and reducing perioperative patient risk. Producing a state of amnesia for pre and post-operative events is desired by all. This study has been undertaken to evaluate the role of three of the benzodiazepines i.e. diazepam, lorazepam and midazolam during general anaesthesia, in providing anxiolysis, sedation and amnesia.Methods: The study included patients with ASA grade I and ASA grade II physical status of both sexes, age ranging between 18-60 years. Patients were divided into three groups of thirty patients each, every group receiving intramuscular injections of diazepam 0.1 mg/kg body weight, lorazepam 0.07 mg/kg body weight and midazolam 0.08 mg/kg body weight respectively; 45 minutes prior to induction of general anaesthesia. Anxiety assessment before premedication along with assessment of sedation after premedication was done.Results: Before premedication the mean values of pulse rate, blood pressure and respiratory rate were not significantly different among the three groups (p>0.05). Maximum changes in these parameters were observed with Midazolam followed by lorazepam and diazepam. The dose of thiopentone used as inducing agent was also lowered significantly in case of midazolam (p<0.05). One patient in midazolam group showed respiratory depression whereas four patients receiving lorazepam and diazepam showed delayed recovery and prolonged sedation, but the effects were self-limiting.Conclusions: Midazolam offers the maximum advantage in allaying anxiety and providing excellent sedation and amnesia during general anaesthesia and proves to be the most suitable premedicant before general anaesthesia.
      PubDate: 2019-04-29
      DOI: 10.18203/2349-3259.ijct20190983
      Issue No: Vol. 6, No. 2 (2019)
       
  • Sexual dimorphism of foramen magnum: a NCCT based study

    • Authors: Haseeb Abdul Wani, Imza Feroz, Saleem Mohammad Dar, Arshed Hussain Parry, Tariq Ahmad Gojwari
      Pages: 52 - 55
      Abstract: Background: Radiological determination of gender relies predominantly on the skeletal radiology and assumes importance in mass natural disasters, bomb explosions, exhumations and warfare where skeletal fragmentation is common. Varied literature is present regarding the role of foramen magnum in establishing gender identification. The objective of the study was to establish normative values of cross-sectional area of foramen magnum in both genders using NCCT and try to ascertain any significant difference in cross-sectional area in the two genders which may help in gender identification.Methods: NCCT head images of 378 subjects were analysed in individuals beyond the age of skeletal immaturity. Free ROI technique using electronic calliper tool was used. The cross-sectional area of foramen magnum was automatically obtained after tracing its whole inner circumference.Results: Mean cross-sectional area of foramen magnum in females was 806.79±106.58 mm2 and was 878.33±98.42 mm2 in males. Although the cross-sectional area in males was greater than females no statistically significant difference was found. The correlation coefficient was found to be weaker (R=0.0413).Conclusions: No statistically significant difference was found between the two genders. The correlation coefficient was also weak to draw any inference about the gender of the skull on CT imaging. Further studies are needed to include other parameters like the sagittal and transverse diameters of foramen magnum in a larger sample to show importance of foramen magnum, if any, in helping gender identification of skeletal remains. 
      PubDate: 2019-04-29
      DOI: 10.18203/2349-3259.ijct20191989
      Issue No: Vol. 6, No. 2 (2019)
       
  • The effect of pedometer supported walking and telemonitoring after disc
           hernia surgery on pain, disability levels, and quality of life: study
           protocol

    • Authors: Kadriye Aldemir, Aysel Gürkan
      Pages: 56 - 62
      Abstract: Background: Surgical intervention is the most common among the methods used to treat LDH, and its success rate is high. Despite this, patients can experience mild to moderate pain and disability after surgery. In the management of this pain and disability, walking forms the first step of rehabilitation and is an easy and long term method. This study was planned to determine the effect of a pedometer supported walking program and telemonitoring after disc hernia surgery on pain, disability levels and quality of life.Methods: This study was planned as a randomized controlled study. Patients will be randomized into the study and control groups through the closed envelope method. Patients in the study group will receive an intervention through a 12 week walking program and weekly telemonitoring. The pain levels of the patients included in the study will be evaluated using the short form Mcgill pain questionnaire, their disability levels will be evaluated using the Oswestry disability index, and their quality of life will be evaluated using the SF-36. Patients in both the study and control groups will be evaluated with regard to pain and disability levels in the follow ups in the 3rd, 7th, and 11th weeks, and with regard to pain, disability, and quality of life in the 15th week.Conclusions: Daily regular walks have great importance in the management of mild lower back pain. This study was planned to determine the effect of walking with a pedometer after LDH surgery with weekly monitoring.
      PubDate: 2019-04-29
      DOI: 10.18203/2349-3259.ijct20191990
      Issue No: Vol. 6, No. 2 (2019)
       
  • Protocol for a prospective multicenter intervention study (URivo study)
           assessing biomarkers in patients with previously treated advanced clear
           cell renal cell carcinoma receiving nivolumab

    • Authors: Hideaki Miyake, Ken-ichi Harada, Yuto Matsushita, Nobuyuki Hinata, Haruhiko Sugimura, Masato Fujisawa
      Pages: 63 - 68
      Abstract: Background: In recent years, immune checkpoint inhibitors have been introduced into routine clinical practice for treating patients with a wide variety of malignant tumors, including advanced renal cell carcinoma (aRCC), resulting in the significant improvement of the prognosis of these patients. However, a reliable biomarker prediciting the clinical course in patients receiving nivolumab has not yet been developed; accordingly, the URivo study was planned to investigate the significance of various candidate biomarkers for aRCC patients treated with nivolumab.Methods: This was designed as a prospective multicenter intervention study, and will include a total of 200 aRCC patients who are scheduled to receive nivolumab followed by treatment with either 1 or 2 tyrosine kinase inhibitors (TKIs). Using resected tumor tissues and serum samples prior to the introduction of nivolumab, the following assessments will be conducted: programmed death ligand-1 (PD-L1) and PD-L2 gene copy number gains by fluorescence in situ hybridization, serum concentrations of PD-L1 and PD-L2 by enzyme-linked immunosorbent assay, and expression of several proteins involved in apoptosis, epithelial-mesenchymal transition, signal transduction and immune reaction by immunohistochemical staining. The outcomes of these assays will be evaluated focusing on the association with the response to nivolumab, overall survival, progression-free survival and disease-specific survival.Conclusions: The significance of various types of candidate biomarker, particularly PD-L1 and PD-L2, will be intensively investigated in this study, and this may offer unique information to determine the optimal indication of nivolumab for aRCC patients following the failure of TKIs.Trial Registration: UMIN000030400; registered April 1, 2018.
      PubDate: 2019-04-29
      DOI: 10.18203/2349-3259.ijct20191991
      Issue No: Vol. 6, No. 2 (2019)
       
 
 
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