for Journals by Title or ISSN
for Articles by Keywords

Publisher: Horizon Research Publishing   (Total: 54 journals)   [Sort by number of followers]

Showing 1 - 54 of 54 Journals sorted alphabetically
Advances in Diabetes and Metabolism     Open Access   (Followers: 19)
Advances in Economics and Business     Open Access   (Followers: 12)
Advances in Energy and Power     Open Access   (Followers: 12)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 7)
Advances in Signal Processing     Open Access   (Followers: 12)
Advances in Zoology and Botany     Open Access  
Bioengineering and Bioscience     Open Access   (Followers: 1)
Cancer and Oncology Research     Open Access   (Followers: 10)
Chemical and Materials Engineering     Open Access   (Followers: 18)
Civil Engineering and Architecture     Open Access   (Followers: 21)
Computational Research     Open Access   (Followers: 1)
Computer Science and Information Technology     Open Access   (Followers: 13)
Energy and Environmental Engineering     Open Access   (Followers: 7)
Environment and Ecology Research     Open Access   (Followers: 7)
Food Science and Technology     Open Access   (Followers: 3, SJR: 0.11, h-index: 6)
Immunology and Infectious Diseases     Open Access   (Followers: 9)
Intl. J. of Biochemistry and Biophysics     Open Access   (Followers: 1)
Intl. J. of Cardiovascular and Cerebrovascular Disease     Open Access   (Followers: 2)
Intl. J. of Neuroscience and Behavioral Science     Open Access   (Followers: 1)
Linguistics and Literature Studies     Open Access   (Followers: 4)
Manufacturing Science and Technology     Open Access   (Followers: 3)
Mathematics and Statistics     Open Access   (Followers: 5)
Nanoscience and Nanoengineering     Open Access   (Followers: 1)
Natural Resources and Conservation     Open Access   (Followers: 6)
Nursing and Health     Open Access   (Followers: 4)
Open J. of Dentistry and Oral Medicine     Open Access  
Sociology and Anthropology     Open Access   (Followers: 5)
Sport and Art     Open Access   (Followers: 1)
Universal J. of Accounting and Finance     Open Access   (Followers: 2)
Universal J. of Agricultural Research     Open Access   (Followers: 1)
Universal J. of Applied Mathematics     Open Access   (Followers: 5)
Universal J. of Applied Science     Open Access   (Followers: 2)
Universal J. of Biomedical Engineering     Open Access  
Universal J. of Chemistry     Open Access  
Universal J. of Clinical Medicine     Open Access  
Universal J. of Communications and Network     Open Access  
Universal J. of Computational Mathematics     Open Access   (Followers: 5)
Universal J. of Control and Automation     Open Access   (Followers: 3)
Universal J. of Educational Research     Open Access   (Followers: 1)
Universal J. of Electrical and Electronic Engineering     Open Access   (Followers: 6)
Universal J. of Engineering Science     Open Access   (Followers: 1)
Universal J. of Food and Nutrition Science     Open Access   (Followers: 5)
Universal J. of Geoscience     Open Access   (Followers: 3)
Universal J. of Industrial and Business Management     Open Access   (Followers: 1)
Universal J. of Management     Open Access   (Followers: 1)
Universal J. of Materials Science     Open Access   (Followers: 3)
Universal J. of Mechanical Engineering     Open Access   (Followers: 11)
Universal J. of Medical Science     Open Access  
Universal J. of Microbiology Research     Open Access  
Universal J. of Physics and Application     Open Access   (Followers: 2)
Universal J. of Plant Science     Open Access  
Universal J. of Psychology     Open Access   (Followers: 2)
Universal J. of Public Health     Open Access   (Followers: 2)
World J. of Computer Application and Technology     Open Access   (Followers: 3)
Journal Cover Advances in Diabetes and Metabolism
  [19 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2332-0052 - ISSN (Online) 2332-0060
   Published by Horizon Research Publishing Homepage  [54 journals]
  • Effects of Aqueous and Ethanolic Extracts of Roasted and Ground Coffee
           Beans of Coffea canephora robusta on Glycemia and Release and Storage of
           Hepatic Glucose in Normoglycemic and Diabetic Rats

    • Abstract: Publication date:  Oct 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  4  Aka F. B. Angelo   Kablan A. L.Claude   and Kati-Coulibaly Séraphin   The drink from the roasted and ground coffee beans of Coffea, which has been blamed, with alcohol, tobacco and drugs have been recognized for over a decade as a drink with positive effects on health. Among its benefits is an inverse association between low coffee consumption and high prevalence of type 2 diabetes. This study aims at evaluating the antidiabetic effects of an aqueous extract of roasted and ground beans of Coffea canephora robusta associated with a sulphonylurea (Glibenclamide) on glycaemia and on the release and storage of hepatic glucose among rats made diabetic by alloxan. Simultaneous oral administration of 20 mg/kg bw of aqueous extract of roasted and ground coffee beans of coffea canephora robusta + 10 mg/kg bw of glibenclamide after 28 days of treatment results in a highly significant decrease in blood glucose in diabetics rats, potentiating the effect of glibenclamide. Compared to aqueous and residual aqueous extracts, the ethanolic extract of roasted and ground beans of Coffea canephora robusta has a better inhibition of the release of hepatic glucose in the normoglycemic rats. After 90 days of treatment, the combination of coffee + glibenclamide favour more the storage of hepatic glucose compared with to diabetic rats treated only with glibenclamide. It appears that the aqueous extract of roasted and ground beans of Coffea canephora robusta would have antidiabetic properties and would act by supporting on the one hand the inhibition of the glycogenolysis and on the other hand the storage of hepatic glucose (glycogenogenesis). These results are quite in favour of the preventive effects from beverage resulting from roasted and ground Coffea in the appearance of type 2 diabetes.
      PubDate: Oct 2017
  • Risk Factors of Gestational Diabetes Mellitus in a Reference Maternal
           Health Care Centre in Southern Benin

    • Abstract: Publication date:  Oct 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  4  Ogoudjobi OM   Sossa Jérôme C   Lokossou MSHS   Tshabu-Aguemon C   Kérékou A   Tandjiékpon E   Denakpo JL   and Perrin R-X   Gestational diabetes mellitus is the most commonly observed endocrine disorder during pregnancy. It results in severe fetal and maternal complications that can increase the fetal morbidity and mortality and the risk for overt diabetes in women. Identification of pregnant women at high risk for gestational diabetes mellitus is therefore needed for early detection in order to reduce its consequences for the mother, the fetus and the newborn. The objective of the study was to identify risk factors for gestational diabetes in a reference maternal health care centre in southern Benin. This was a case-control study carried out from 1st February 2015 to 31st July 2017 in reference maternal health care centre at the University Hospital of Porto-Novo. All pregnant women with a gestational age of 24 to 28 weeks of amenorrhea, who utilized antenatal care service of University Hospital of Porto-Novo, were screened for gestational diabetes mellitus. The chi-square test was used to identify risk factors for gestational diabetes mellitus. The statistical significance was fixed at p < 0.05. Of the 967 pregnant women participated in the study, 73 cases of gestational diabetes mellitus, were detected (7.5%). Risk factors of gestational diabetes identified were: maternal age ≥ 35 years [OR 7.82 CI 95% (4.75-12.89)], body mass index ≥ 25 kg/m2 [OR 9.56 CI 95% (5.17-17.70)], family history of diabetes at 1st degree [OR 2.78 CI 95% (1.53-5.06)], a history of fetal macrosomia [OR 7.25 CI 95% (3.11-16.92)], a history of stillbirth [OR 2.98 CI 95% (1.78-5.00)], an antecedent of more than two spontaneous miscarriages [OR 1.93 CI 95% (1.19-3.12)] and the personal history of hypertension [OR 3.91 CI 95% (1.52-10.07)]. This study confirmed the influence of maternal age and some medical and obstetric histories as risk factors of gestational diabetes mellitus. These pregnant women at high risk of gestational diabetes mellitus should benefit from early detection.
      PubDate: Oct 2017
  • Post Prandial Hyperglycemia: A Real Threat for Patients with Type 2
           Diabetes Mellitus

    • Abstract: Publication date:  Jul 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  3  Arif Faruqui   The aim of this article is to evaluate the impact of postprandial hyperglycemia in patients with type 2 diabetes mellitus (T2DM). Postprandial hyperglycemia is a major determinant in overall glycemic control. Diabetic mellitus is an endocrine disorder steadily increasing worldwide, particularly in the developing countries like India. Diabetic patients are at high risk of cardiovascular events and mealtime plasma glucose fluctuations are important cardiovascular risk factors in type 2 diabetic patients. Diabetes is also one of the most important risk factors for chronic kidney disease. For diabetic patients with chronic kidney disease (CKD), the risk of cardiovascular disease is even higher. CKD can impair the ability of the kidneys to metabolize drugs and as a consequence a dose adjustment or an extended dose interval is usually needed in CKD patients in order to keep an optimal safety/efficacy profile. Oral hypoglycemic agents like glinides and alpha glucosidase inhibitors do not require dose adjustments and hence can be used safely in patients with CKD. Oral treatment with Repaglinide has proven beneficial effect on cardiovascular risk factors. It is therefore very important to use pharmacological tools allowing keeping post-meal glucose oscillations within narrow range. Regimens that target both fasting and post meal glycemia are needed to achieve optimal glucose control to prevent microvascular and macrovascular complications.
      PubDate: Jul 2017
  • Effect of Vitamin E and C Supplementation on Oxidative Stress in Diabetic

    • Abstract: Publication date:  Jul 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  3  Rajneesh Prajapat   and Ijen Bhattacharya   Background: Diabetes is a metabolic epidemic that causes vascular complications. The presence of oxidative stress in diabetes patients and the preventive role of vitamins therapy have been reported by many researchers. Vitamins supplementation improves antioxidant defense system in diabetes patients. Aim: To study the effect of vitamin E and C supplementation on oxidative stress in diabetes patients. Methods: Subjects enrolled in the study received 500 mg of both vitamin C and vitamin E daily twice for 4 months under medical supervision. Fasting blood glucose, MDA, catalase, SOD and nitric oxide were determined. Serum vitamin E and plasma vitamin C were also measured. Statistical analysis was performed using SPSS 12.0. Numerical normally distributed and categorical data were compared using independent t-test. Data were presented as means ± SD. Results: After supplementation with vitamin E and C in diabetic patients, a signify decrease in FBS, MDA levels and increase in serum nitrite, erythrocyte SOD, blood catalase, vitamin E and vitamin C levels were observed. A negative correlation between MDA and vitamins was observed. Conclusion: Vitamin E and C supplementation is useful for the treatment of oxidative stress related complications in diabetes patients. Prescribed medicines contain active ingredients that may cause effect on the patients in terms of side-effects. Controlled vitamin therapy for prolonged period may not cause any side-effects, as well as play effective role for the management of type 2 diabetic related oxidative stress.
      PubDate: Jul 2017
  • Evaluation of Antidiabetic Activity of Aqueous and Etylic alcohol Extracts
           of Stem Bark of Xylopia villosa Chipp (Annonaceae)

    • Abstract: Publication date:  Jan 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  1  Kouame Yao Yves   Okpekon Aboua Timothée   and Yapi Houphouët Félix   This study aims to evaluate antidiabetic activity of aqueous and ethanolic extracts of Xylopia villosa stem bark. Induction of diabetes was made with Streptozocin on male rats. Treatments of diabetic rats with aqueous and ethanolic extracts of Xylopia villosa at doses of 100 and 200 mg / kg bw and Daonil (the reference molecule) at doses of 10 and 20 mg / kg bw revealed that ethanolic extract (200 mg / kg) bw behaved like Daonil (20 mg / kg bw). It is the therapeutic dose needed to correct hyperglycaemia. At this dose, the ethanolic extract allowed an important insulin secretion equivalent to the non-diabetic control rats and allowed the gradual reconstitution of the islets of Langerhans and the reappearance of the β cells responsible for the secretion of the insulin. This situation would be linked to the flavonoids and zinc contained in the extracts. Indeed, Zinc, in addition to being a powerful antioxidant, would have a protective insulin action and an important insulin-like effect by activating the kinases involved in insulin signaling and the phosphorylations necessary for insulin efficacy. Also, flavonoids improve the sensitivity of the body's cells to insulin, which reduces the incidence of type 2 diabetes.
      PubDate: Jan 2017
  • Epigenetics and Systems Physiology of Nutrition: An Overview

    • Abstract: Publication date:  Jan 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  1  Abhay Kumar Pandey   and Garima Pandey   Understanding of basic mechanisms mediating epigenetic regulation is essential for knowing cellular differentiation and genomic programming for function. Epigenetics refers to chemical marks on genes and their products, impacting gene expression without any alteration in DNA base sequence. These marks are copied and carried over through cell division and yet, are reversible with appropriate molecular manipulations such as DNA methylation, chromatin rearrangement, microRNA mediated feedback checks etc. Such changes underlie fetal origins of adult chronic non communicable diseases, and project the primacy of nutrition in epigenetic aberrations. Regulation of over 25000 genes through epigenetic processes in health and disease opens vast sphere for physiologic understanding of nutrition and nutrients. Genomic science has systems approach to understanding. In present context that shapes as dynamic emergent nutrition physiology of health and disease. Present article presents a brief overview of the perspectives.
      PubDate: Jan 2017
  • Obesity and Lipid Profile Study in Type 2 Diabetes Patients with Auditory
           and Reaction Time Deficits and Non-diabetic Control Subjects

    • Abstract: Publication date:  Jan 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  1  Abhay Kumar Pandey   Deepti Pandey   and Abha Pandit   Background: Obesity is lead component of metabolic syndrome and dyslipidaemia is shown to play diverse roles in type-2 diabetes and its complications resulting in morbidity and mortality Aim: Obesity and lipid profile changes in diabetes are to be assessed and their possible bearing on observed hearing loss and delayed reaction time reasoned with reference to scientific understanding. Method: 51 type-2 diabetes patients and 51 age sex matched non-diabetic controls are examined for obesity parameters and lipid profile. Possible relevance of the findings to observed complications in the patients is contemplated by literature reference. Conclusion: Obesity and dyslipidemia appear to be important in initiation, progression and complications of type 2 diabetes. Consensus needs to develop on routine management of diabetes with due cognizance of need to treat obesity and dyslipidemia, beyond usual focus on glycaemic control.
      PubDate: Jan 2017
  • Control of Diabetic Dyslipidemia among Type-II Diabetics in Western Region
           of the Republic of Macedonia

    • Abstract: Publication date:  Apr 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  2  Ylber Jani   Sotiraq Xhunga   Artur Serani   Bekim Pocesta   Fatmir Ferati   Dali Lala   Agim Zeqiri   Arben Mirto   Atila Rexhepi   and Ahmet Kamberi   Background: Serum lipids are poorly controlled in most European countries and the control rate is even lower in diabetic patients. All international guidelines recommend aggressive management of lipids in this population. To date, evidence on whether diabetic dyslipidemia is adequately managed or not in western region of the Republic of Macedonia are scarce. Objective: To determine the degree of dyslipidemia control in diabetics patients, according to evidence and current guidelines, by primary healthcare physicians, in our region. Methods: This is a multicenter, non-interventional, observational study. Prospectively tested were 555 participants. The study was conducted at outpatient in Primary Health Care Clinics in 8 towns, on western region Republic of Macedonia. Study participants were selected among primary care patient, who were receiving ongoing care for diabetes mellitus type-2(T2DM) and dyslipidemia, during 1 calendar year. We recorded information from all healthcare encounters during 1 calendar year. Results: Our study showed that among diabetic patients with overt cardio-vascular disease(CVD), target LDL-C level of ( < 70 mg/dL),was achieved in 21.4% of patients, whereas 78.6% of patient did not achieved target LDL-C level, respectively.(p=.0000). Among diabetic patients without overt CVD, target LDL-C level of (< 100 mg/dL) was achieved in 44.2% of patients, whereas 55.7% of patients did not achieved target LDL-C level, respectively (p=.06). It was observed that, only 36.7% of the total study population, had achieved LDL-C goals according to evidence and current guidelines, whereas 63.3% of patients did not achieved target LDL-C level, despite an ongoing medical treatment, respectively.(p= .0000). Among the total study population (N=555), target LDL-C level was achieved in 14.0% of the female patients and in 47.3% of the male patients, respectively. (p=.002). Age, BMI and Duration of T2DM, were significantly associated with uncontrolled LDL-C level, according to evidence and current guidelines. (Age: OR=1.214; 95%CI 1.165-1.1263; p=.000; BMI: OR=1.270; 95% CI 1.203-1.341; p=.000; Duration of T2DM: OR=1.035; 95% CI 0.950-1.121;p=.036). Conclusions: Control rates of dyslipidemia among T2DM patients, in the western region of the Republic of Macedonia, continue to be alarmingly low, particularly in women. It is clear that aggressive dyslipidemia management is the need of the hour in patients with diabetes.
      PubDate: Apr 2017
  • Correlation between Blood Biochemical Metabolites Milk Yield, Dry Matter
           Intake and Energy Balance in Dairy Cows during Early and Mid Lactation

    • Abstract: Publication date:  Apr 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  2  Radojica Djoković   Vladimir Kurćubić   Zoran Ilić   Marko Cincović   Miroslav Lalović   Boban Jašović   and Jovan Bojkovski   The objective of the present study was to investigate nutritional and metabolic status in Simmental cows during early and mid-lactation. Fifteen early lactation cows and 15 mid lactation cows were chosen for the analysis. Blood samples were collected to measure beta-hydroxybutyrate (BHB), non-esterified fatty acids (NEFA), triglycerides (TG), glucose and the activity of aspartate transaminase (AST). Blood metabolites, milk yield, dry matter intake (DMI) and energy balance (EB) were recorded. Correlation analysis showed that DMI was significantly negatively correlated with NEFA, BHB and AST, and positively with glucose and TG. EB was significantly negatively correlated with NEFA, BHB and AST, and positively with glucose. Early lactation as compared to mid lactation cows were found to have significantly higher blood serum concentrations of NEFA, BHB and AST activities and lower blood serum concentrations of glucose and TG, but not significant. These metabolic changes were in correlation with DMI and EB, but not with milk yield. Suggest that they can serve as useful indicators of the nutritional and metabolic status of dairy cows during lactation.
      PubDate: Apr 2017
  • Combined Effect of Vitamin C and E Dose on Type 2 Diabetes Patients

    • Abstract: Publication date:  Apr 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  2  Rajneesh Prajapat   Ijen Bhattacharya   and Anupam Jakhalia   Diabetes is a metabolic disorder that causes vascular complications. As vitamin C and E is known for its beneficial effects on blood sugar, serum lipids and glycated haemoglobin (HbA1c). In the present study, we assess the combined effect of vitamin C and E on blood sugar (FBS), serum creatinine (SC), total cholesterol (TC), low and high density lipoprotein (LDL, HDL), and glycated haemoglobin (HbAIc) in type 2 diabetes mellitus patients. A total of 50 patients with type 2 diabetes referred to Rama Hospital (NCR), India, were included in the study. They received 500 mg daily twice of both vitamin C and E for 4 months. Fasting blood sugar (FBS), serum creatinine (SC), total cholesterol (TC), low and high density lipoprotein (LDL, HDL), and HbAIc were measured before and after vitamin C and E consumption and the results were analyzed. A significant decrease in FBS, TC level and non-significant decrease in SC, LDL, and HbA1c level was seen in the patients supplemented with 500 mg of both vitamin C and E twice in a day for 4 months. Results indicate that daily consumption of 500 mg of vitamin C and E for 4 months may be beneficial for decreasing the FBS, TC, SC, LDL, and HbA1c and slight raise in HDL and calcium level in patients with type II diabetes and thus reducing the risk of complications.
      PubDate: Apr 2017
  • Exploring Uncounted Contribution of Women in Bangladesh: Barriers,
           Implications and Opportunities

    • Abstract: Publication date:  Oct 2016
      Source:Advances in Diabetes and Metabolism  Volume  4  Number  4  Tania Haque   Work is typically divided along gender lines with men being responsible for the outside work and as the main income- earner and women for housework and child care. Women's unpaid work is not recognized and therefore, women are considered as passive dependents. Non-recognition of women's activity not only leads to undervaluation of economic contribution but also contributes to their lower status in society relative to men in Bangladesh. Therefore unpaid work is not a gender-neutral bundle of chores that women perform out of comparative advantage or lower resources but instead it is an integral part to the reproduction of unequal power relations between men and women.
      PubDate: Oct 2016
  • In-silico Structure Modeling and Docking Studies Using Dipeptidyl
           Peptidase 4 (DPP4) Inhibitors against Diabetes Type-2

    • Abstract: Publication date:  Oct 2016
      Source:Advances in Diabetes and Metabolism  Volume  4  Number  4  Rajneesh Prajapat   and Ijen Bhattacharya   Recently recognized class of oral hypoglycemic, dipeptidyl peptidase (DPP4) inhibitors could block the dipeptidyl peptidase 4 (DPP4) enzymes. DPP4 is an intrinsic membrane glycoprotein and a serine exopeptidase that plays a major role in glucose metabolism and responsible for the degradation of incretins such as GLP-1, therefore providing a useful treatment to diabetes mellitus type 2. The present work focused on the study of the structural homology modeling of dipeptidyl peptidase 4 [Homo sapiens] (NP_001926). The Ramachandran plot of DPP4 (NP_001926.2) has 88.9% residues in the most favoured region while template 2QT9 has 96.1% residues in the most favoured region. The model was validated by using protein structure tools RAMPAGE and Prochek for reliability. Docking studies were further performed to analyze the interaction mode between selected DPP4 inhibitor anagliptin derivative SKK and receptor DPP4 by using Hex 8.0.0. The in-silico analysis was useful to identify the novel inhibitor that illustrates better activity than the other reported inhibitors.
      PubDate: Oct 2016
  • Estimated Glomerular Filtration Rate and Associated Clinical and
           Biochemical Characteristics in Type 2 Diabetes Patients

    • Abstract: Publication date:  Oct 2016
      Source:Advances in Diabetes and Metabolism  Volume  4  Number  4  Abha Pandit   and Abhay Kumar Pandey   Background: Improved check on cardiovascular mortality due to diabetes has fast increased life span and prevalence of nephropathy in diabetics world over. Its variegated insidious sequel requiring useful markers for timely detection and address. Professional dictat is for periodic monitoring of estimated glomerular filtration rate (eGFR) in the diabetes patients. An indication of nephropathy from overall routine clinical and laboratory findings is worthwhile too. Objective: Study of clinico-demographic and biochemical indices associated with diabetic nephropathy defined by cutoff decline in eGFR, was undertaken to generate local evidence base for practice guidance. Method: 136 patients of type 2 diabetes mellitus under treatment at medicine outdoor for at least past one year were classified by eGFR cutoff of 60ml/min/1.73m2 in to renal impaired (chronic kidney disease CKD group) and unimpaired groups. In a cross sectional study their clinico-demographic characteristics and biochemical investigation profiles were analysed and compared to elucidate local clinical evidence on relevant markers of CKD in type 2 diabetes. Result and Conclusion: Central obesity, long standing disease, inadequate glycaemic control, macroproteinuria, lower HDL-cholesterol and lower plasma antioxidant capacity profiles prominently associated diabetic patients with CKD. Hypertension was not prominently associated. Weight reduction, antioxidant nutrient supplements, better glycaemic control and improvement of HDL-cholesterol profiles were apparently demanding greater attention and care toward abetting/retarding occurrence of nephropathy in type 2 diabetes patients.
      PubDate: Oct 2016
  • Serum Calcium Levels in Correlation with Glycated Hemoglobin in Type 2
           Diabetic Sudanese Patients

    • Abstract: Publication date:  Oct 2016
      Source:Advances in Diabetes and Metabolism  Volume  4  Number  4  Safaa Abed ELRahman Hassan   Wigdan Abdel Rahman Elsheikh   Nazik Ibrahim Abdel Rahman   and Nabiela M. ElBagir   The present work is a cross-sectional study aimed to evaluate the serum levels of calcium and Glycated Hemoglobin (HbA1c) of (40) patients with type 2 diabetes mellitus, attending Center clinic in Khartoum North- Sudan, and (40) apparently healthy (non-diabetic) volunteers as control group. Age and sex of the test group were matched with the control group. Serum levels of calcium were measured by auto analyzer Bs-200 (instruments and reagents from Mindray Company) and HbA1c amount was measured by CERA-STATTM 4000 Analyzer (reagents and instruments from Ceragem Medisys Company). Data was analyzed using SPSS. The results showed a significant reduction in the mean of serum calcium level of the diabetic group when compared with the control group (p value
      PubDate: Oct 2016
  • In Silico Structure Analysis of Type 2 Diabetes Associated Cysteine
           Protease Calpain-10 (CAPN10)

    • Abstract: Publication date:  May 2016
      Source:Advances in Diabetes and Metabolism  Volume  4  Number  2  Rajneesh Prajapat   and Ijen Bhattacharya   Calpain-10 (CAPN10) is a cysteine protease that is known to hydrolyze specific substrates significant for calcium-regulated signaling pathways and it's activated by intracellular calcium (Ca2+). The calpain10 is known to be involved in the cellular degenerative processes that characterize several diseases such as cancer, stroke and heart attack. The role of calpain10 was recently identified and associated with diabetes mellitus type 2. In this paper, the homology modelling procedure was used to determine the 3D structure of human calpain10 (AAH07553). The μ-calpain (1QXP) of Rattus norvegicus was selected as a template for the construction of calpain10 model. Ramachandran plot of calpain10 (AAH07553) has only 55.9% residues in the most favored regions, while template μ-calpain (1QXP) has 69.3% residues in the most favored regions. The model was validated by using protein structure tools RAMPAGE and Prochek for reliability. 3D structure of calpain10 suggested its active site remains conserved among family members and the major interactions are similar to those observed for the template (1QXP).
      PubDate: May 2016
  • Effect of Medicinal Mushrooms on L-arginine/NO System in Red Blood Cells
           of Streptozotocin-induced Diabetic Rats

    • Abstract: Publication date:  May 2016
      Source:Advances in Diabetes and Metabolism  Volume  4  Number  2  Taras Y. Vitak   Solomon P. Wasser   Eviatar Nevo   and Natalia O. Sybirna   Increase of nitric oxide production resulted in the development of oxidative-nitrosative stress that is considered to be an etiological cause of many diseases, including diabetes mellitus (DM). Recently, it was found that red blood cells (RBCs) are able to produce nitric oxide (NO), and due to the ability of hemoglobin to bind to nitric oxide, are the main depot of NO. Medicinal mushrooms are widely used in the correction and treatment of many diseases, including diabetes. Our previous results showed that Agaricus brasiliensis and Ganoderma lucidum have hypoglycemic effects and improve the functional state of RBCs. In this study, the influence of submerged cultivated mycelium powder (SCMP) of the abovementioned mushrooms on the red blood cells L-arginine/NO system of streptozotocin-induced DM rats was investigated. Wistar outbread white rats were used in the study. Streptozotocin was intraperitoneal injected one time at a dose of 50 mg/kg body weight. Mushroom preparations were orally administered at a dose of 1 g/kg/day for 14 days. We showed that administration of medicinal mushrooms SCMP to diabetic animals caused restoration of NO-synthase activity, normalized nitrite content (in case of A. brasiliensis), and led to nitrate growth. Therefore, treatment with mushroom mycelia normalizes the production of nitric oxide to physiological values.
      PubDate: May 2016
  • Risk of Diabetes Mellitus in the Occurrence of Acute Ischemic Stroke at a
           Tertiary Care Hospital in Bangladesh

    • Abstract: Publication date:  Jul 2016
      Source:Advances in Diabetes and Metabolism  Volume  4  Number  3  Nazia Sharmin   Nasima Sultana   Hafizur Rahman   Taniza Rahman   Sanjella Nahreen Chowdhury   Md. Abdullah Yusuf   and Zakiur Rahman   Background: Acute ischemic stroke more frequently occurs in diabetic patients. Objective: The purpose of the present study was to observe the risk of diabetes mellitus in the occurrence of acute ischemic stroke in Bangladesh. Methodology: This case control study was carried out in the Department of Biochemistry at Dhaka Medical College, Dhaka, Bangladesh from January 2014 to December 2014 for a period of one (01) year. The case group consisted of male and female patients (age range 18-65 years) presenting with ischemic stroke. Age and sex matched healthy individuals were selected as the control group. History of diabetes of both cases and controls were recorded and blood sample was collected from both case and control after overnight fasting for the estimation of blood sugar. Results: A total number of 100 study subjects were taken of which 50 subjects presented with acute ischemic stroke were considered as case and the remaining 50 healthy subjects were taken as control. Diabetes mellitus was more commonly reported in case group (46.0%) than control group (6.0%) and the difference was found statistically significant (p= 0.001).The risk estimation was calculated at 13.34 OR (95% C.I. 3.66 to 48.62). Conclusions: The findings of this study conclude that diabetes mellitus was found to be significantly associated with acute ischemic stroke.
      PubDate: Jul 2016
  • Safety and Efficacy of Fixed Dose Combination of Voglibose, Glimepiride
           and Metformin in Indian Type 2 Diabetes Mellitus Patients

    • Abstract: Publication date:  Jul 2016
      Source:Advances in Diabetes and Metabolism  Volume  4  Number  3  Arif A. Faruqui   Worldwide diabetes mellitus is highly prevalent and economically devastating illness. This study was a post marketing surveillance (PMS), non-randomized, open, non-comparative, mono-centric study. The drug administered was a fixed dose combination of voglibose 0.2 mg; glimepiride ½ mg and metformin 500 mg sustained release (SR). Fifty type 2 diabetic patients were given fixed dose combination twice daily with major meals for 3 months. Baseline value was recorded for glycated haemoglobin (HbA1c), fasting plasma glucose (FPG) and post prandial blood glucose/hyperglycemia (PPHG) level. There was significant decrease from baseline in HBA1c value 10.6 ± 1.3 vs. 6.6 ± 0.4 (P< 0.0001), FPG levels 208.33 mg/dl vs. 118.06 (P< 0.0001), and PPHG levels 360.14 mg/dl vs. 168.36, (P< 0.0001) after 3 months of treatment. The combination was found to be effective in controlling both fasting and post prandial glucose level and was well tolerated. Investigator commented that the use of triple drug combination is a good option in the management of type 2 diabetes which controls both fasting as well as post prandial blood glucose and ultimately HbA1c values.
      PubDate: Jul 2016
  • The Effect of Butyric Acid on GLUT4 and IRS1 Expression in Human
           Preadipocytes in vitro

    • Abstract: Publication date:  Jul 2016
      Source:Advances in Diabetes and Metabolism  Volume  4  Number  3  L. R. Maness   Understanding the dietary components that can prevent and treat diabetes mellitus types 2 (DMT2) is important to millions of people who are at risk for and currently suffer from the various aspects of this disease. Our diets can affect our health at the level of gene expression, thus, determining foods that can positively affect cellular activity can be advantageous to our daily lives. Butyric acid is a fatty acid that can be fermented from fiber by beneficial intestinal bacteria. This substance has been shown to improve insulin sensitivity and metabolic activity in mice and to affect genes involved in the insulin pathway both in cell culture and in mice. This study determined the effect of butyric acid on the expression of two genes important to insulin sensitivity, glucose transporter 4 (GLUT4) and insulin receptor substrate 1 (IRS1), in human preadipocytes in vitro. Butyric acid at concentrations 0.05 mg/ml, 0.1 mg/ml, and 1.0 mg/ml each increased the expression of both of these genes, indicating that cells are more sensitive to insulin in the presence of this component. This study indicates that butyric acid can be implemented into dietary plans to prevent and control DMT2 by increasing daily fiber intake.
      PubDate: Jul 2016
  • Diabetes: Symptoms, Cause and Potential Natural Therapeutic Methods

    • Abstract: Publication date:  Feb 2016
      Source:Advances in Diabetes and Metabolism  Volume  4  Number  1  Anjali Awasthi   Nikhat Parween   Vijay Kumar Singh   Arif Anwar   Birendra Prasad   and Jitendra Kumar   Diabetes mellitus (DM) commonly referred as diabetes is a complex, heterogeneous disorder characterized by high blood glucose level. Insulin insufficiency or ineffective insulin termed as insulin resistance contributes to diabetes etiology. There are two major forms of DM termed as type-1 diabetes and type-2 diabetes. Type-1 diabetes is an autoimmune disease resulting in destruction of pancreatic cell leading to severe lack of insulin. Whereas, type-2 diabetes develop due to inefficient insulin utilization referred as insulin resistance or insufficient quantity of insulin production. Diabetes has become a global disease and in 2014 WHO has reported 9% of adults (18 years and above) had diabetes. The above trend is expected to increase in forthcoming years due to sedentary lifestyle, unhealthy diet and excessive body weight. Insulin signaling pathway is the key pathway involved in regulating blood glucose level. There are several factors reported to alter insulin secretion as well as insulin signaling pathway resulting in etiology and progression of diabetes. Diabetes treatment aims at controlling blood glucose level. There are various kinds of chemical drug and herbal/natural products being used to effectively control blood glucose level. Composition, dosage and mode of action of chemical drugs are well established. However, the mode of action of traditional and herbal medications, which are used widely by 90% of the population in developing countries for primary healthcare, is still poorly investigated. Around 800 plants have been reported worldwide which have anti-diabetic potential. This review explores and gives the insight on the insulin signaling pathway and other known factors which modulates diabetes. It also collates the potential of various anti-diabetic herbal/phytochemical medications which have been scientifically investigated for their anti-diabetic virtue and mode of action.
      PubDate: Feb 2016
  • Healthy and Gestational Diabetic Human Placental Fructose 1,6 Bisphosphate
           Aldolase; Comparative Investigation of Kinetic Properties and Inhibition
           Effects of DHAP, ATP, and Mg+2 ion

    • Abstract: Publication date:  Feb 2016
      Source:Advances in Diabetes and Metabolism  Volume  4  Number  1  Neşe Hayat Aksoy   and Pakize Dogan   Fructose-1,6-bisphosphate aldolase plays an effective role in glucose metabolism and gluconeogenic pathway, and reversibly catalyzes the split of fructose 1,6-bisphosphate into the triose phosphates D-glyceraldehyde phosphate and dihydroxyacetone phosphate. Aldolase has 160 kDa molecular weight and three tissue specific isozymes. Gestational diabetes mellitus is defined as glucose intolerance that begins or is first detected during pregnancy. The placenta is a temporary established organ that operates exclusively for the time of pregnancy. It acts as a natural barrier between the maternal and fetal blood circulations and performs a wide range of endocrine and transport functions. In diabetes, the placenta undergoes a variety of structural and functional changes. Healthy and gestational diabetic human placental fructose-1, 6-bisphosphate aldolases were purified and investigated the substrate kinetic properties, in the previous studies. In this comparative study, we wanted to carry out characteristics of inhibition kinetics of aldolase in healthy and diabetic human placenta. The specific activity was defined as the number of activity units per mg of protein. Inhibition kinetics of fructose-bisphosphate aldolase was studied using dihydroxyacetone-phosphate, adenosine triphosphate, and magnesium ion as inhibitors. For healthy placental Aldolase it was detected that, adenosine triphosphate is partial competitive; dihydroxyacetone-phosphate is noncompetitive and magnesium metal is pure-competitive inhibitor. It was found that, dihydroxyacetone-phosphate is competitive; adenosine triphosphate is partial competitive and magnesium is partial competitive inhibitor of gestational diabetic human placental Aldolase.
      PubDate: Feb 2016
  • Glycaemic Control among Rural Health Consumers: A Retrospective Study of a
           Diabetes Center

    • Abstract: Publication date:  Oct 2015
      Source:Advances in Diabetes and Metabolism  Volume  3  Number  2  Daniel R Terry   Kristen Glenister   John Kilmartin   Gloria Kilmartin   Rob Sands   Jeremy Fowler   and Julian Wright   Aim: The aim of this paper is to highlight the successes of and challenges faced by a publically funded diabetes center in a regional area. Methods: Demographic and laboratory cross sectional data were collected from electronic patient records. Data from a patient's very first test undertaken when attending the hospital and the latest test undertaken at the Diabetes center were noted and included age, sex, residential postcode and glycated haemoglobin (HbA1c) levels. Results: A third of patients reached the therapeutic guideline of 'very good control' for HbA1c levels. Females had lower Hb1Ac levels, while males and those that lived further away from the diabetes center had higher levels of HbA1c. However, a significant improvement in glycaemic control among men and those who lived 'out of town' was noted, while the corresponding pattern for women was not evident. Conclusion: The study demonstrated that there was an overall improvement in diabetes control among health consumers who attend the regional diabetes center, however, female patients residing in town showed a negligible change over time. At risk' patient groups may need further targeting for intensive intervention to achieve optimal diabetes control, even within the diabetes center.
      PubDate: Oct 2015
  • The Effect of Butyric Acid on Gene Expression of GLUT2 and IRS1 on Human
           Hepatocytes in vitro

    • Abstract: Publication date:  Feb 2015
      Source:Advances in Diabetes and Metabolism  Volume  3  Number  1  L. R. Maness   Diabetes mellitus type 2 (DMT2) affects hundreds of millions of people globally and costs billions of dollars each year. The importance of research toward prevention and treatment of this disease cannot be overestimated. Butyric acid is a short chain fatty acid that has been shown in mice and in intestinal cell culture studies to increase insulin sensitivity at the level of gene expression. However, little or no work has been reported on its effects on human liver cells. The present study determined the changes in gene expression of glucose transporter 2 (GLUT2) and insulin receptor substrate 1 (IRS1) on insulin shocked THLE-2 human liver cells exposed in vitro to the following concentrations of butyric acid in mg/ml: 0.05, 0.1, and 1.0. GLUT2 and IRS1 had increases in expression at doses of butyric acid previously found to be nontoxic in human serum. This work indicates that more studies involving the effects of butyric acid on gene expression of insulin resistant human hepatocytes are warranted.
      PubDate: Feb 2015
  • Evaluation of Antioxidant Status in Myocardial Infarction in Diabetic and
           Non-diabetic Subjects: A Comparative Study

    • Abstract: Publication date:  Feb 2015
      Source:Advances in Diabetes and Metabolism  Volume  3  Number  1  K. N Subhakumari   Reshmy G S   and Sajitha Krishnan. P   Cellular oxidative stress is the leading cause of the worst outcome of myocardial infarction (MI) in diabetes. Diabetes Mellitus is one of the important risk factors for heart pathology, because of increased production of Reactive oxygen Species(ROS).The present study was designed to find out the antioxidant status in diabetic and non-diabetic MI Patients.100 MI patients were grouped into 50 Diabetic MI(group 2) and 50 Non diabetic MI(group 3) and was compared with age matched 50 controls (group1). Malondialdehyde(MDA) or Thiobarbituric acid reactive substances (TBARs), antioxidant enzymes Superoxide Dismutase(SOD) &Catalase were measured in erythrocytes and Vitamin C in plasma was measured. The result showed that there is a significant decrease in the antioxidant status in diabetic and non-diabetic MI patients and a simultaneous significant increase in the lipid peroxidation .Thus there is an imbalance between oxidant and antioxidant molecules in MI patients, and magnitude of imbalance is greater in diabetic MI patients, possibly because of greater oxidative stress in diabetic patients. Potentially antioxidant therapy may play a critical role in reducing morbidity and mortality in MI.
      PubDate: Feb 2015
  • Fructose 1, 6 Bisphosphate Aldolase from Gestational Diabetic Human
           Placenta: Purification, Identification, and Investigation of Kinetic

    • Abstract: Publication date:  Dec 2015
      Source:Advances in Diabetes and Metabolism  Volume  3  Number  3  Neşe Hayat Aksoy   and Pakize Dogan   Gestational diabetes mellitus is described as glucose intolerance at various degrees that is first detected during pregnancy. In diabetic complications, there are changes in placental function, particularly with respect to intake, transmit, and utilization of glucose, and also in glycolysis and glycolytic enzymes. The placenta possibly plays a critical role in protecting the fetus from adverse effects caused by the maternal diabetic conditions. Fructose 1,6-bisphosphate aldolase, a main glycolytic enzyme, catalyses the cleavage of fructose 1,6-bisphosphate, resulting in two three-carbon products in many cells. In this study, we principally have investigated the presence of aldolase in diabetic human placenta and then purified the enzyme. We also determined the optimum conditions of enzyme assay measurements. With this procedure, we determined the specific activity of placental aldolase as 590, 94 mU/mg protein, and aldolase was purified about 63,0 fold from gestational diabetic human placenta. The molecular weight of human placental aldolase was found as 160 kDa. In present study, substrate kinetics were also investigated, and two different Km and Vmax values at high and low concentrations of substrate Fructose 1,6-bisphosphate were observed. High substrate concentration range is determined as the linear substrate concentration zone. Therefore, advanced kinetic studies had been performed at this linear zone. Enzymatic assays were carried out, and substrate kinetic properties were determined. According to this determination, Vmax value of gestational diabetic placental fructose 1,6-bisphosphate aldolase was found as 939,548±60,869 U/mg and Km as 24,304±2,948 mM.
      PubDate: Dec 2015
  • Yacon (Smallanthus sonchifolius (Poepp. & Endl.) H. Robinson) Improved
           Erythrocyte Resistance to Oxidative Stress in Streptozotocin-induced
           Diabetic Rats

    • Abstract: Publication date:  Dec 2015
      Source:Advances in Diabetes and Metabolism  Volume  3  Number  3  Mariia Khokhla   Olexandra Horbulinska   Halina Hachkova   Lidiya Mishchenko   Olexandr Shulga   Rosa Vildanova   and Natalia Sybirna   Yacon demonstrating prominent hypoglycemic action and having high content of biologically active compounds, is recognized for their ability to capture free radicals. This study is aimed to evaluate the influence of yacon leaves and root tubers water extracts and aqueous suspension of root tubers powder on rats' erythrocyte antioxidant defense system under the experimental diabetes mellitus type 1. Healthy animals and animals with diabetes mellitus were treated with water extracts of yacon leaves and root tubers at dose 70 or 500 mg / kg /day and with aqueous suspension of root tubers powder at dose 500 mg / kg /day or the same suspension which was stabilized by biocomplex PS. Thiobarbituric acid reactive substances (TBARS) and protein carbonyl content (PCC), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activity in erythrocytes lysates were measured. Water extracts of yacon leaves and root tubers and aqueous suspension of root tubers powder possess significant antioxidant effect, which was indicated by the decrease of TBARS and PCC and increase in SOD, CAT and GPx activity. Root tubers of yacon water extract at a dose of 500 mg/kg/day and aqueous suspension of root tubers powder stabilized by biocomplex PS possess he most pronounced antioxidant effect.
      PubDate: Dec 2015
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
Home (Search)
Subjects A-Z
Publishers A-Z
Your IP address:
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-