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Publisher: Horizon Research Publishing   (Total: 54 journals)   [Sort by number of followers]

Showing 1 - 54 of 54 Journals sorted alphabetically
Advances in Diabetes and Metabolism     Open Access   (Followers: 23)
Advances in Economics and Business     Open Access   (Followers: 14)
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Immunology and Infectious Diseases     Open Access   (Followers: 9)
Intl. J. of Biochemistry and Biophysics     Open Access   (Followers: 1)
Intl. J. of Cardiovascular and Cerebrovascular Disease     Open Access   (Followers: 2)
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Sport and Art     Open Access   (Followers: 1)
Universal J. of Accounting and Finance     Open Access   (Followers: 2)
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Universal J. of Food and Nutrition Science     Open Access   (Followers: 5)
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Universal J. of Materials Science     Open Access   (Followers: 3)
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Universal J. of Medical Science     Open Access  
Universal J. of Microbiology Research     Open Access  
Universal J. of Physics and Application     Open Access   (Followers: 2)
Universal J. of Plant Science     Open Access  
Universal J. of Psychology     Open Access   (Followers: 3)
Universal J. of Public Health     Open Access   (Followers: 2)
World J. of Computer Application and Technology     Open Access   (Followers: 3)
Journal Cover
Advances in Diabetes and Metabolism
Number of Followers: 23  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2332-0052 - ISSN (Online) 2332-0060
Published by Horizon Research Publishing Homepage  [54 journals]
  • Effects of Aqueous and Ethanolic Extracts of Roasted and Ground Coffee
           Beans of Coffea canephora robusta on Glycemia and Release and Storage of
           Hepatic Glucose in Normoglycemic and Diabetic Rats

    • Abstract: Publication date:  Oct 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  4  Aka F. B. Angelo   Kablan A. L.Claude   and Kati-Coulibaly Séraphin   The drink from the roasted and ground coffee beans of Coffea, which has been blamed, with alcohol, tobacco and drugs have been recognized for over a decade as a drink with positive effects on health. Among its benefits is an inverse association between low coffee consumption and high prevalence of type 2 diabetes. This study aims at evaluating the antidiabetic effects of an aqueous extract of roasted and ground beans of Coffea canephora robusta associated with a sulphonylurea (Glibenclamide) on glycaemia and on the release and storage of hepatic glucose among rats made diabetic by alloxan. Simultaneous oral administration of 20 mg/kg bw of aqueous extract of roasted and ground coffee beans of coffea canephora robusta + 10 mg/kg bw of glibenclamide after 28 days of treatment results in a highly significant decrease in blood glucose in diabetics rats, potentiating the effect of glibenclamide. Compared to aqueous and residual aqueous extracts, the ethanolic extract of roasted and ground beans of Coffea canephora robusta has a better inhibition of the release of hepatic glucose in the normoglycemic rats. After 90 days of treatment, the combination of coffee + glibenclamide favour more the storage of hepatic glucose compared with to diabetic rats treated only with glibenclamide. It appears that the aqueous extract of roasted and ground beans of Coffea canephora robusta would have antidiabetic properties and would act by supporting on the one hand the inhibition of the glycogenolysis and on the other hand the storage of hepatic glucose (glycogenogenesis). These results are quite in favour of the preventive effects from beverage resulting from roasted and ground Coffea in the appearance of type 2 diabetes.
      PubDate: Oct 2017
       
  • Post Prandial Hyperglycemia: A Real Threat for Patients with Type 2
           Diabetes Mellitus

    • Abstract: Publication date:  Jul 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  3  Arif Faruqui   The aim of this article is to evaluate the impact of postprandial hyperglycemia in patients with type 2 diabetes mellitus (T2DM). Postprandial hyperglycemia is a major determinant in overall glycemic control. Diabetic mellitus is an endocrine disorder steadily increasing worldwide, particularly in the developing countries like India. Diabetic patients are at high risk of cardiovascular events and mealtime plasma glucose fluctuations are important cardiovascular risk factors in type 2 diabetic patients. Diabetes is also one of the most important risk factors for chronic kidney disease. For diabetic patients with chronic kidney disease (CKD), the risk of cardiovascular disease is even higher. CKD can impair the ability of the kidneys to metabolize drugs and as a consequence a dose adjustment or an extended dose interval is usually needed in CKD patients in order to keep an optimal safety/efficacy profile. Oral hypoglycemic agents like glinides and alpha glucosidase inhibitors do not require dose adjustments and hence can be used safely in patients with CKD. Oral treatment with Repaglinide has proven beneficial effect on cardiovascular risk factors. It is therefore very important to use pharmacological tools allowing keeping post-meal glucose oscillations within narrow range. Regimens that target both fasting and post meal glycemia are needed to achieve optimal glucose control to prevent microvascular and macrovascular complications.
      PubDate: Jul 2017
       
  • Effect of Vitamin E and C Supplementation on Oxidative Stress in Diabetic
           Patients

    • Abstract: Publication date:  Jul 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  3  Rajneesh Prajapat   and Ijen Bhattacharya   Background: Diabetes is a metabolic epidemic that causes vascular complications. The presence of oxidative stress in diabetes patients and the preventive role of vitamins therapy have been reported by many researchers. Vitamins supplementation improves antioxidant defense system in diabetes patients. Aim: To study the effect of vitamin E and C supplementation on oxidative stress in diabetes patients. Methods: Subjects enrolled in the study received 500 mg of both vitamin C and vitamin E daily twice for 4 months under medical supervision. Fasting blood glucose, MDA, catalase, SOD and nitric oxide were determined. Serum vitamin E and plasma vitamin C were also measured. Statistical analysis was performed using SPSS 12.0. Numerical normally distributed and categorical data were compared using independent t-test. Data were presented as means ± SD. Results: After supplementation with vitamin E and C in diabetic patients, a signify decrease in FBS, MDA levels and increase in serum nitrite, erythrocyte SOD, blood catalase, vitamin E and vitamin C levels were observed. A negative correlation between MDA and vitamins was observed. Conclusion: Vitamin E and C supplementation is useful for the treatment of oxidative stress related complications in diabetes patients. Prescribed medicines contain active ingredients that may cause effect on the patients in terms of side-effects. Controlled vitamin therapy for prolonged period may not cause any side-effects, as well as play effective role for the management of type 2 diabetic related oxidative stress.
      PubDate: Jul 2017
       
  • Evaluation of Antidiabetic Activity of Aqueous and Etylic alcohol Extracts
           of Stem Bark of Xylopia villosa Chipp (Annonaceae)

    • Abstract: Publication date:  Jan 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  1  Kouame Yao Yves   Okpekon Aboua Timothée   and Yapi Houphouët Félix   This study aims to evaluate antidiabetic activity of aqueous and ethanolic extracts of Xylopia villosa stem bark. Induction of diabetes was made with Streptozocin on male rats. Treatments of diabetic rats with aqueous and ethanolic extracts of Xylopia villosa at doses of 100 and 200 mg / kg bw and Daonil (the reference molecule) at doses of 10 and 20 mg / kg bw revealed that ethanolic extract (200 mg / kg) bw behaved like Daonil (20 mg / kg bw). It is the therapeutic dose needed to correct hyperglycaemia. At this dose, the ethanolic extract allowed an important insulin secretion equivalent to the non-diabetic control rats and allowed the gradual reconstitution of the islets of Langerhans and the reappearance of the β cells responsible for the secretion of the insulin. This situation would be linked to the flavonoids and zinc contained in the extracts. Indeed, Zinc, in addition to being a powerful antioxidant, would have a protective insulin action and an important insulin-like effect by activating the kinases involved in insulin signaling and the phosphorylations necessary for insulin efficacy. Also, flavonoids improve the sensitivity of the body's cells to insulin, which reduces the incidence of type 2 diabetes.
      PubDate: Jan 2017
       
  • Epigenetics and Systems Physiology of Nutrition: An Overview

    • Abstract: Publication date:  Jan 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  1  Abhay Kumar Pandey   and Garima Pandey   Understanding of basic mechanisms mediating epigenetic regulation is essential for knowing cellular differentiation and genomic programming for function. Epigenetics refers to chemical marks on genes and their products, impacting gene expression without any alteration in DNA base sequence. These marks are copied and carried over through cell division and yet, are reversible with appropriate molecular manipulations such as DNA methylation, chromatin rearrangement, microRNA mediated feedback checks etc. Such changes underlie fetal origins of adult chronic non communicable diseases, and project the primacy of nutrition in epigenetic aberrations. Regulation of over 25000 genes through epigenetic processes in health and disease opens vast sphere for physiologic understanding of nutrition and nutrients. Genomic science has systems approach to understanding. In present context that shapes as dynamic emergent nutrition physiology of health and disease. Present article presents a brief overview of the perspectives.
      PubDate: Jan 2017
       
  • Obesity and Lipid Profile Study in Type 2 Diabetes Patients with Auditory
           and Reaction Time Deficits and Non-diabetic Control Subjects

    • Abstract: Publication date:  Jan 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  1  Abhay Kumar Pandey   Deepti Pandey   and Abha Pandit   Background: Obesity is lead component of metabolic syndrome and dyslipidaemia is shown to play diverse roles in type-2 diabetes and its complications resulting in morbidity and mortality Aim: Obesity and lipid profile changes in diabetes are to be assessed and their possible bearing on observed hearing loss and delayed reaction time reasoned with reference to scientific understanding. Method: 51 type-2 diabetes patients and 51 age sex matched non-diabetic controls are examined for obesity parameters and lipid profile. Possible relevance of the findings to observed complications in the patients is contemplated by literature reference. Conclusion: Obesity and dyslipidemia appear to be important in initiation, progression and complications of type 2 diabetes. Consensus needs to develop on routine management of diabetes with due cognizance of need to treat obesity and dyslipidemia, beyond usual focus on glycaemic control.
      PubDate: Jan 2017
       
  • Control of Diabetic Dyslipidemia among Type-II Diabetics in Western Region
           of the Republic of Macedonia

    • Abstract: Publication date:  Apr 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  2  Ylber Jani   Sotiraq Xhunga   Artur Serani   Bekim Pocesta   Fatmir Ferati   Dali Lala   Agim Zeqiri   Arben Mirto   Atila Rexhepi   and Ahmet Kamberi   Background: Serum lipids are poorly controlled in most European countries and the control rate is even lower in diabetic patients. All international guidelines recommend aggressive management of lipids in this population. To date, evidence on whether diabetic dyslipidemia is adequately managed or not in western region of the Republic of Macedonia are scarce. Objective: To determine the degree of dyslipidemia control in diabetics patients, according to evidence and current guidelines, by primary healthcare physicians, in our region. Methods: This is a multicenter, non-interventional, observational study. Prospectively tested were 555 participants. The study was conducted at outpatient in Primary Health Care Clinics in 8 towns, on western region Republic of Macedonia. Study participants were selected among primary care patient, who were receiving ongoing care for diabetes mellitus type-2(T2DM) and dyslipidemia, during 1 calendar year. We recorded information from all healthcare encounters during 1 calendar year. Results: Our study showed that among diabetic patients with overt cardio-vascular disease(CVD), target LDL-C level of ( < 70 mg/dL),was achieved in 21.4% of patients, whereas 78.6% of patient did not achieved target LDL-C level, respectively.(p=.0000). Among diabetic patients without overt CVD, target LDL-C level of (< 100 mg/dL) was achieved in 44.2% of patients, whereas 55.7% of patients did not achieved target LDL-C level, respectively (p=.06). It was observed that, only 36.7% of the total study population, had achieved LDL-C goals according to evidence and current guidelines, whereas 63.3% of patients did not achieved target LDL-C level, despite an ongoing medical treatment, respectively.(p= .0000). Among the total study population (N=555), target LDL-C level was achieved in 14.0% of the female patients and in 47.3% of the male patients, respectively. (p=.002). Age, BMI and Duration of T2DM, were significantly associated with uncontrolled LDL-C level, according to evidence and current guidelines. (Age: OR=1.214; 95%CI 1.165-1.1263; p=.000; BMI: OR=1.270; 95% CI 1.203-1.341; p=.000; Duration of T2DM: OR=1.035; 95% CI 0.950-1.121;p=.036). Conclusions: Control rates of dyslipidemia among T2DM patients, in the western region of the Republic of Macedonia, continue to be alarmingly low, particularly in women. It is clear that aggressive dyslipidemia management is the need of the hour in patients with diabetes.
      PubDate: Apr 2017
       
  • Correlation between Blood Biochemical Metabolites Milk Yield, Dry Matter
           Intake and Energy Balance in Dairy Cows during Early and Mid Lactation

    • Abstract: Publication date:  Apr 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  2  Radojica Djoković   Vladimir Kurćubić   Zoran Ilić   Marko Cincović   Miroslav Lalović   Boban Jašović   and Jovan Bojkovski   The objective of the present study was to investigate nutritional and metabolic status in Simmental cows during early and mid-lactation. Fifteen early lactation cows and 15 mid lactation cows were chosen for the analysis. Blood samples were collected to measure beta-hydroxybutyrate (BHB), non-esterified fatty acids (NEFA), triglycerides (TG), glucose and the activity of aspartate transaminase (AST). Blood metabolites, milk yield, dry matter intake (DMI) and energy balance (EB) were recorded. Correlation analysis showed that DMI was significantly negatively correlated with NEFA, BHB and AST, and positively with glucose and TG. EB was significantly negatively correlated with NEFA, BHB and AST, and positively with glucose. Early lactation as compared to mid lactation cows were found to have significantly higher blood serum concentrations of NEFA, BHB and AST activities and lower blood serum concentrations of glucose and TG, but not significant. These metabolic changes were in correlation with DMI and EB, but not with milk yield. Suggest that they can serve as useful indicators of the nutritional and metabolic status of dairy cows during lactation.
      PubDate: Apr 2017
       
  • Combined Effect of Vitamin C and E Dose on Type 2 Diabetes Patients

    • Abstract: Publication date:  Apr 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  2  Rajneesh Prajapat   Ijen Bhattacharya   and Anupam Jakhalia   Diabetes is a metabolic disorder that causes vascular complications. As vitamin C and E is known for its beneficial effects on blood sugar, serum lipids and glycated haemoglobin (HbA1c). In the present study, we assess the combined effect of vitamin C and E on blood sugar (FBS), serum creatinine (SC), total cholesterol (TC), low and high density lipoprotein (LDL, HDL), and glycated haemoglobin (HbAIc) in type 2 diabetes mellitus patients. A total of 50 patients with type 2 diabetes referred to Rama Hospital (NCR), India, were included in the study. They received 500 mg daily twice of both vitamin C and E for 4 months. Fasting blood sugar (FBS), serum creatinine (SC), total cholesterol (TC), low and high density lipoprotein (LDL, HDL), and HbAIc were measured before and after vitamin C and E consumption and the results were analyzed. A significant decrease in FBS, TC level and non-significant decrease in SC, LDL, and HbA1c level was seen in the patients supplemented with 500 mg of both vitamin C and E twice in a day for 4 months. Results indicate that daily consumption of 500 mg of vitamin C and E for 4 months may be beneficial for decreasing the FBS, TC, SC, LDL, and HbA1c and slight raise in HDL and calcium level in patients with type II diabetes and thus reducing the risk of complications.
      PubDate: Apr 2017
       
 
 
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