for Journals by Title or ISSN
for Articles by Keywords
help

Publisher: Horizon Research Publishing   (Total: 54 journals)   [Sort by number of followers]

Showing 1 - 54 of 54 Journals sorted alphabetically
Advances in Diabetes and Metabolism     Open Access   (Followers: 16)
Advances in Economics and Business     Open Access   (Followers: 11)
Advances in Energy and Power     Open Access   (Followers: 12)
Advances in Pharmacology and Pharmacy     Open Access   (Followers: 7)
Advances in Signal Processing     Open Access   (Followers: 11)
Advances in Zoology and Botany     Open Access  
Bioengineering and Bioscience     Open Access   (Followers: 1)
Cancer and Oncology Research     Open Access   (Followers: 8)
Chemical and Materials Engineering     Open Access   (Followers: 13)
Civil Engineering and Architecture     Open Access   (Followers: 18)
Computational Research     Open Access   (Followers: 1)
Computer Science and Information Technology     Open Access   (Followers: 13)
Energy and Environmental Engineering     Open Access   (Followers: 7)
Environment and Ecology Research     Open Access   (Followers: 7)
Food Science and Technology     Open Access   (Followers: 3, SJR: 0.11, h-index: 6)
Immunology and Infectious Diseases     Open Access   (Followers: 9)
Intl. J. of Biochemistry and Biophysics     Open Access   (Followers: 1)
Intl. J. of Cardiovascular and Cerebrovascular Disease     Open Access   (Followers: 2)
Intl. J. of Neuroscience and Behavioral Science     Open Access   (Followers: 1)
Linguistics and Literature Studies     Open Access   (Followers: 4)
Manufacturing Science and Technology     Open Access   (Followers: 2)
Mathematics and Statistics     Open Access   (Followers: 5)
Nanoscience and Nanoengineering     Open Access   (Followers: 1)
Natural Resources and Conservation     Open Access   (Followers: 6)
Nursing and Health     Open Access   (Followers: 3)
Open J. of Dentistry and Oral Medicine     Open Access  
Sociology and Anthropology     Open Access   (Followers: 5)
Sport and Art     Open Access   (Followers: 1)
Universal J. of Accounting and Finance     Open Access   (Followers: 2)
Universal J. of Agricultural Research     Open Access   (Followers: 1)
Universal J. of Applied Mathematics     Open Access   (Followers: 5)
Universal J. of Applied Science     Open Access   (Followers: 2)
Universal J. of Biomedical Engineering     Open Access  
Universal J. of Chemistry     Open Access  
Universal J. of Clinical Medicine     Open Access  
Universal J. of Communications and Network     Open Access  
Universal J. of Computational Mathematics     Open Access   (Followers: 4)
Universal J. of Control and Automation     Open Access   (Followers: 3)
Universal J. of Educational Research     Open Access  
Universal J. of Electrical and Electronic Engineering     Open Access   (Followers: 6)
Universal J. of Engineering Science     Open Access   (Followers: 1)
Universal J. of Food and Nutrition Science     Open Access   (Followers: 5)
Universal J. of Geoscience     Open Access   (Followers: 3)
Universal J. of Industrial and Business Management     Open Access   (Followers: 1)
Universal J. of Management     Open Access  
Universal J. of Materials Science     Open Access   (Followers: 3)
Universal J. of Mechanical Engineering     Open Access   (Followers: 10)
Universal J. of Medical Science     Open Access  
Universal J. of Microbiology Research     Open Access  
Universal J. of Physics and Application     Open Access   (Followers: 2)
Universal J. of Plant Science     Open Access  
Universal J. of Psychology     Open Access   (Followers: 2)
Universal J. of Public Health     Open Access   (Followers: 2)
World J. of Computer Application and Technology     Open Access   (Followers: 3)
Journal Cover Advances in Diabetes and Metabolism
  [16 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2332-0052 - ISSN (Online) 2332-0060
   Published by Horizon Research Publishing Homepage  [54 journals]
  • Effects of Aqueous and Ethanolic Extracts of Roasted and Ground Coffee
           Beans of Coffea canephora robusta on Glycemia and Release and Storage of
           Hepatic Glucose in Normoglycemic and Diabetic Rats

    • Abstract: Publication date:  Oct 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  4  Aka F. B. Angelo   Kablan A. L.Claude   and Kati-Coulibaly Séraphin   The drink from the roasted and ground coffee beans of Coffea, which has been blamed, with alcohol, tobacco and drugs have been recognized for over a decade as a drink with positive effects on health. Among its benefits is an inverse association between low coffee consumption and high prevalence of type 2 diabetes. This study aims at evaluating the antidiabetic effects of an aqueous extract of roasted and ground beans of Coffea canephora robusta associated with a sulphonylurea (Glibenclamide) on glycaemia and on the release and storage of hepatic glucose among rats made diabetic by alloxan. Simultaneous oral administration of 20 mg/kg bw of aqueous extract of roasted and ground coffee beans of coffea canephora robusta + 10 mg/kg bw of glibenclamide after 28 days of treatment results in a highly significant decrease in blood glucose in diabetics rats, potentiating the effect of glibenclamide. Compared to aqueous and residual aqueous extracts, the ethanolic extract of roasted and ground beans of Coffea canephora robusta has a better inhibition of the release of hepatic glucose in the normoglycemic rats. After 90 days of treatment, the combination of coffee + glibenclamide favour more the storage of hepatic glucose compared with to diabetic rats treated only with glibenclamide. It appears that the aqueous extract of roasted and ground beans of Coffea canephora robusta would have antidiabetic properties and would act by supporting on the one hand the inhibition of the glycogenolysis and on the other hand the storage of hepatic glucose (glycogenogenesis). These results are quite in favour of the preventive effects from beverage resulting from roasted and ground Coffea in the appearance of type 2 diabetes.
      PubDate: Oct 2017
       
  • Risk Factors of Gestational Diabetes Mellitus in a Reference Maternal
           Health Care Centre in Southern Benin

    • Abstract: Publication date:  Oct 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  4  Ogoudjobi OM   Sossa Jérôme C   Lokossou MSHS   Tshabu-Aguemon C   Kérékou A   Tandjiékpon E   Denakpo JL   and Perrin R-X   Gestational diabetes mellitus is the most commonly observed endocrine disorder during pregnancy. It results in severe fetal and maternal complications that can increase the fetal morbidity and mortality and the risk for overt diabetes in women. Identification of pregnant women at high risk for gestational diabetes mellitus is therefore needed for early detection in order to reduce its consequences for the mother, the fetus and the newborn. The objective of the study was to identify risk factors for gestational diabetes in a reference maternal health care centre in southern Benin. This was a case-control study carried out from 1st February 2015 to 31st July 2017 in reference maternal health care centre at the University Hospital of Porto-Novo. All pregnant women with a gestational age of 24 to 28 weeks of amenorrhea, who utilized antenatal care service of University Hospital of Porto-Novo, were screened for gestational diabetes mellitus. The chi-square test was used to identify risk factors for gestational diabetes mellitus. The statistical significance was fixed at p < 0.05. Of the 967 pregnant women participated in the study, 73 cases of gestational diabetes mellitus, were detected (7.5%). Risk factors of gestational diabetes identified were: maternal age ≥ 35 years [OR 7.82 CI 95% (4.75-12.89)], body mass index ≥ 25 kg/m2 [OR 9.56 CI 95% (5.17-17.70)], family history of diabetes at 1st degree [OR 2.78 CI 95% (1.53-5.06)], a history of fetal macrosomia [OR 7.25 CI 95% (3.11-16.92)], a history of stillbirth [OR 2.98 CI 95% (1.78-5.00)], an antecedent of more than two spontaneous miscarriages [OR 1.93 CI 95% (1.19-3.12)] and the personal history of hypertension [OR 3.91 CI 95% (1.52-10.07)]. This study confirmed the influence of maternal age and some medical and obstetric histories as risk factors of gestational diabetes mellitus. These pregnant women at high risk of gestational diabetes mellitus should benefit from early detection.
      PubDate: Oct 2017
       
  • Post Prandial Hyperglycemia: A Real Threat for Patients with Type 2
           Diabetes Mellitus

    • Abstract: Publication date:  Jul 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  3  Arif Faruqui   The aim of this article is to evaluate the impact of postprandial hyperglycemia in patients with type 2 diabetes mellitus (T2DM). Postprandial hyperglycemia is a major determinant in overall glycemic control. Diabetic mellitus is an endocrine disorder steadily increasing worldwide, particularly in the developing countries like India. Diabetic patients are at high risk of cardiovascular events and mealtime plasma glucose fluctuations are important cardiovascular risk factors in type 2 diabetic patients. Diabetes is also one of the most important risk factors for chronic kidney disease. For diabetic patients with chronic kidney disease (CKD), the risk of cardiovascular disease is even higher. CKD can impair the ability of the kidneys to metabolize drugs and as a consequence a dose adjustment or an extended dose interval is usually needed in CKD patients in order to keep an optimal safety/efficacy profile. Oral hypoglycemic agents like glinides and alpha glucosidase inhibitors do not require dose adjustments and hence can be used safely in patients with CKD. Oral treatment with Repaglinide has proven beneficial effect on cardiovascular risk factors. It is therefore very important to use pharmacological tools allowing keeping post-meal glucose oscillations within narrow range. Regimens that target both fasting and post meal glycemia are needed to achieve optimal glucose control to prevent microvascular and macrovascular complications.
      PubDate: Jul 2017
       
  • Effect of Vitamin E and C Supplementation on Oxidative Stress in Diabetic
           Patients

    • Abstract: Publication date:  Jul 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  3  Rajneesh Prajapat   and Ijen Bhattacharya   Background: Diabetes is a metabolic epidemic that causes vascular complications. The presence of oxidative stress in diabetes patients and the preventive role of vitamins therapy have been reported by many researchers. Vitamins supplementation improves antioxidant defense system in diabetes patients. Aim: To study the effect of vitamin E and C supplementation on oxidative stress in diabetes patients. Methods: Subjects enrolled in the study received 500 mg of both vitamin C and vitamin E daily twice for 4 months under medical supervision. Fasting blood glucose, MDA, catalase, SOD and nitric oxide were determined. Serum vitamin E and plasma vitamin C were also measured. Statistical analysis was performed using SPSS 12.0. Numerical normally distributed and categorical data were compared using independent t-test. Data were presented as means ± SD. Results: After supplementation with vitamin E and C in diabetic patients, a signify decrease in FBS, MDA levels and increase in serum nitrite, erythrocyte SOD, blood catalase, vitamin E and vitamin C levels were observed. A negative correlation between MDA and vitamins was observed. Conclusion: Vitamin E and C supplementation is useful for the treatment of oxidative stress related complications in diabetes patients. Prescribed medicines contain active ingredients that may cause effect on the patients in terms of side-effects. Controlled vitamin therapy for prolonged period may not cause any side-effects, as well as play effective role for the management of type 2 diabetic related oxidative stress.
      PubDate: Jul 2017
       
  • Evaluation of Antidiabetic Activity of Aqueous and Etylic alcohol Extracts
           of Stem Bark of Xylopia villosa Chipp (Annonaceae)

    • Abstract: Publication date:  Jan 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  1  Kouame Yao Yves   Okpekon Aboua Timothée   and Yapi Houphouët Félix   This study aims to evaluate antidiabetic activity of aqueous and ethanolic extracts of Xylopia villosa stem bark. Induction of diabetes was made with Streptozocin on male rats. Treatments of diabetic rats with aqueous and ethanolic extracts of Xylopia villosa at doses of 100 and 200 mg / kg bw and Daonil (the reference molecule) at doses of 10 and 20 mg / kg bw revealed that ethanolic extract (200 mg / kg) bw behaved like Daonil (20 mg / kg bw). It is the therapeutic dose needed to correct hyperglycaemia. At this dose, the ethanolic extract allowed an important insulin secretion equivalent to the non-diabetic control rats and allowed the gradual reconstitution of the islets of Langerhans and the reappearance of the β cells responsible for the secretion of the insulin. This situation would be linked to the flavonoids and zinc contained in the extracts. Indeed, Zinc, in addition to being a powerful antioxidant, would have a protective insulin action and an important insulin-like effect by activating the kinases involved in insulin signaling and the phosphorylations necessary for insulin efficacy. Also, flavonoids improve the sensitivity of the body's cells to insulin, which reduces the incidence of type 2 diabetes.
      PubDate: Jan 2017
       
  • Epigenetics and Systems Physiology of Nutrition: An Overview

    • Abstract: Publication date:  Jan 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  1  Abhay Kumar Pandey   and Garima Pandey   Understanding of basic mechanisms mediating epigenetic regulation is essential for knowing cellular differentiation and genomic programming for function. Epigenetics refers to chemical marks on genes and their products, impacting gene expression without any alteration in DNA base sequence. These marks are copied and carried over through cell division and yet, are reversible with appropriate molecular manipulations such as DNA methylation, chromatin rearrangement, microRNA mediated feedback checks etc. Such changes underlie fetal origins of adult chronic non communicable diseases, and project the primacy of nutrition in epigenetic aberrations. Regulation of over 25000 genes through epigenetic processes in health and disease opens vast sphere for physiologic understanding of nutrition and nutrients. Genomic science has systems approach to understanding. In present context that shapes as dynamic emergent nutrition physiology of health and disease. Present article presents a brief overview of the perspectives.
      PubDate: Jan 2017
       
  • Obesity and Lipid Profile Study in Type 2 Diabetes Patients with Auditory
           and Reaction Time Deficits and Non-diabetic Control Subjects

    • Abstract: Publication date:  Jan 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  1  Abhay Kumar Pandey   Deepti Pandey   and Abha Pandit   Background: Obesity is lead component of metabolic syndrome and dyslipidaemia is shown to play diverse roles in type-2 diabetes and its complications resulting in morbidity and mortality Aim: Obesity and lipid profile changes in diabetes are to be assessed and their possible bearing on observed hearing loss and delayed reaction time reasoned with reference to scientific understanding. Method: 51 type-2 diabetes patients and 51 age sex matched non-diabetic controls are examined for obesity parameters and lipid profile. Possible relevance of the findings to observed complications in the patients is contemplated by literature reference. Conclusion: Obesity and dyslipidemia appear to be important in initiation, progression and complications of type 2 diabetes. Consensus needs to develop on routine management of diabetes with due cognizance of need to treat obesity and dyslipidemia, beyond usual focus on glycaemic control.
      PubDate: Jan 2017
       
  • Control of Diabetic Dyslipidemia among Type-II Diabetics in Western Region
           of the Republic of Macedonia

    • Abstract: Publication date:  Apr 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  2  Ylber Jani   Sotiraq Xhunga   Artur Serani   Bekim Pocesta   Fatmir Ferati   Dali Lala   Agim Zeqiri   Arben Mirto   Atila Rexhepi   and Ahmet Kamberi   Background: Serum lipids are poorly controlled in most European countries and the control rate is even lower in diabetic patients. All international guidelines recommend aggressive management of lipids in this population. To date, evidence on whether diabetic dyslipidemia is adequately managed or not in western region of the Republic of Macedonia are scarce. Objective: To determine the degree of dyslipidemia control in diabetics patients, according to evidence and current guidelines, by primary healthcare physicians, in our region. Methods: This is a multicenter, non-interventional, observational study. Prospectively tested were 555 participants. The study was conducted at outpatient in Primary Health Care Clinics in 8 towns, on western region Republic of Macedonia. Study participants were selected among primary care patient, who were receiving ongoing care for diabetes mellitus type-2(T2DM) and dyslipidemia, during 1 calendar year. We recorded information from all healthcare encounters during 1 calendar year. Results: Our study showed that among diabetic patients with overt cardio-vascular disease(CVD), target LDL-C level of ( < 70 mg/dL),was achieved in 21.4% of patients, whereas 78.6% of patient did not achieved target LDL-C level, respectively.(p=.0000). Among diabetic patients without overt CVD, target LDL-C level of (< 100 mg/dL) was achieved in 44.2% of patients, whereas 55.7% of patients did not achieved target LDL-C level, respectively (p=.06). It was observed that, only 36.7% of the total study population, had achieved LDL-C goals according to evidence and current guidelines, whereas 63.3% of patients did not achieved target LDL-C level, despite an ongoing medical treatment, respectively.(p= .0000). Among the total study population (N=555), target LDL-C level was achieved in 14.0% of the female patients and in 47.3% of the male patients, respectively. (p=.002). Age, BMI and Duration of T2DM, were significantly associated with uncontrolled LDL-C level, according to evidence and current guidelines. (Age: OR=1.214; 95%CI 1.165-1.1263; p=.000; BMI: OR=1.270; 95% CI 1.203-1.341; p=.000; Duration of T2DM: OR=1.035; 95% CI 0.950-1.121;p=.036). Conclusions: Control rates of dyslipidemia among T2DM patients, in the western region of the Republic of Macedonia, continue to be alarmingly low, particularly in women. It is clear that aggressive dyslipidemia management is the need of the hour in patients with diabetes.
      PubDate: Apr 2017
       
  • Correlation between Blood Biochemical Metabolites Milk Yield, Dry Matter
           Intake and Energy Balance in Dairy Cows during Early and Mid Lactation

    • Abstract: Publication date:  Apr 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  2  Radojica Djoković   Vladimir Kurćubić   Zoran Ilić   Marko Cincović   Miroslav Lalović   Boban Jašović   and Jovan Bojkovski   The objective of the present study was to investigate nutritional and metabolic status in Simmental cows during early and mid-lactation. Fifteen early lactation cows and 15 mid lactation cows were chosen for the analysis. Blood samples were collected to measure beta-hydroxybutyrate (BHB), non-esterified fatty acids (NEFA), triglycerides (TG), glucose and the activity of aspartate transaminase (AST). Blood metabolites, milk yield, dry matter intake (DMI) and energy balance (EB) were recorded. Correlation analysis showed that DMI was significantly negatively correlated with NEFA, BHB and AST, and positively with glucose and TG. EB was significantly negatively correlated with NEFA, BHB and AST, and positively with glucose. Early lactation as compared to mid lactation cows were found to have significantly higher blood serum concentrations of NEFA, BHB and AST activities and lower blood serum concentrations of glucose and TG, but not significant. These metabolic changes were in correlation with DMI and EB, but not with milk yield. Suggest that they can serve as useful indicators of the nutritional and metabolic status of dairy cows during lactation.
      PubDate: Apr 2017
       
  • Combined Effect of Vitamin C and E Dose on Type 2 Diabetes Patients

    • Abstract: Publication date:  Apr 2017
      Source:Advances in Diabetes and Metabolism  Volume  5  Number  2  Rajneesh Prajapat   Ijen Bhattacharya   and Anupam Jakhalia   Diabetes is a metabolic disorder that causes vascular complications. As vitamin C and E is known for its beneficial effects on blood sugar, serum lipids and glycated haemoglobin (HbA1c). In the present study, we assess the combined effect of vitamin C and E on blood sugar (FBS), serum creatinine (SC), total cholesterol (TC), low and high density lipoprotein (LDL, HDL), and glycated haemoglobin (HbAIc) in type 2 diabetes mellitus patients. A total of 50 patients with type 2 diabetes referred to Rama Hospital (NCR), India, were included in the study. They received 500 mg daily twice of both vitamin C and E for 4 months. Fasting blood sugar (FBS), serum creatinine (SC), total cholesterol (TC), low and high density lipoprotein (LDL, HDL), and HbAIc were measured before and after vitamin C and E consumption and the results were analyzed. A significant decrease in FBS, TC level and non-significant decrease in SC, LDL, and HbA1c level was seen in the patients supplemented with 500 mg of both vitamin C and E twice in a day for 4 months. Results indicate that daily consumption of 500 mg of vitamin C and E for 4 months may be beneficial for decreasing the FBS, TC, SC, LDL, and HbA1c and slight raise in HDL and calcium level in patients with type II diabetes and thus reducing the risk of complications.
      PubDate: Apr 2017
       
  • Variations in the Bedside Methods of Evaluating Diabetic Peripheral
           Neuropathy among Patients with Type 2 Diabetes. A Challenge for Primary
           Health Care Physicians in Trinidad a High Prevalence Setting for Type 2
           Diabetes

    • Abstract: Publication date:  Oct 2013
      Source:Advances in Diabetes and Metabolism  Volume  1  Number  2  Kameel Mungrue   and Rene Marchan   Objective: The purpose of this study is to compare four measurements used in the diagnosis of DN, (1) symptom scoring, (2) physical examination scoring, (3) Semmes Weinstein monofilament testing, and (4) vibration sensation among patients with T2DM attending primary care facilities in North Trinidad. In addition, the study will demonstrate discrepancies between these four methods as well as estimate the prevalence of DN. Subjects and Methods: A cross-sectional survey of 14 primary care facilities chosen randomly in North Trinidad was conducted. Of the 292 patients that were screened for entry into our study, 276 met the inclusion criteria. . Using four standard clinical methods ie Symptom Scoring, Physical Examination, Monofilament testing and Vibration Perception the proportion of patient with neuropathy was measured and compared. Results: The mean age of the sample population was 60.8 SD ± 11.1 with the average duration of T2DM being 10.2 SD ± 8.4 years. Additionally, there were more females than males with a female to male ratio of 2.3:1. The proportion of participants testing positive for neuropathy by Symptom Scoring, Physical Examination, Monofilament testing and Vibration Perception was 82.6%, 54%, 42.4% and 25.4% respectively. Conclusion: In conclusion the diagnosis of peripheral neuropathy can be made only after a careful clinical examination with more than 1 test, as recommended by the American Diabetes Association. However monofilament testing may in a primary care setting may not be accurate and relevant.
      PubDate: Oct 2013
       
  • Adomian’s Decomposition Method to Squeezing Flow and Heat Transfer
           between two Parallel Disks with Velocity Slip and Temperature Jump

    • Abstract: Publication date:  Oct 2013
      Source:Advances in Diabetes and Metabolism  Volume  1  Number  2  Muhammad Usman   Aqsa Nazir   Zertaisha Naheed   and Syed Tauseef Mohyud-Din   In this paper, we are apply Adomian’s Decomposition Method to find appropriate solutions of to squeezing flow and heat transfer between two parallel disks with velocity slip, temperature jump which are of utmost importance in applied and engineering sciences. A concrete relation between the basic ideas of the proposed technique and the existing literature is also presented. Numerical results coupled with graphical representation explicitly reveal the complete reliability of the proposed algorithm
      PubDate: Oct 2013
       
  • Enhancement of Solubility with Formulation & in-vitro Evaluation of Oral
           Nateglinide Compacts by Liquisolid Technique

    • Abstract: Publication date:  Dec  2013
      Source:Advances in Diabetes and Metabolism  Volume  1  Number  3  Mokale Vinod   Naik Jitendra   Patil Komal   Chaudhari Rahul   and Khairnar Gokul   A Liquisolid system is the one of the novel technique to enhance the dissolution rate of poorly water soluble drug such as Nateglinide. In this technique liquisolid system refers to formulation of formed by water insoluble drug mix with non-volatile solvent which is further converted into free flowing, non adherent powder form and which is directly compressed into tablets. In that the propylene glycol is used as non-volatile solvent in which drug having high solubility, microcrystalline cellulose and aerosil (silica) acts as carrier and coating material in the ratio of 10:1 and 20:1 respectively. Sodium starch glycolate acts as superdisintegrants and magnesium stearate as glidant in liquisolid system. The prepared liquisolid system were evaluated to their flowing properties such as bulk density, tap density, Hausner’s ratio, Carr’s index, and angle of repose. Fourier Transform Infrared spectroscopy (FTIR) and X Ray Diffraction (XRD) study show no interaction between the drug and excipients. Further tablets were evaluated hardness, diameter, thickness, weight variation, friability, disintegration test, uniformity of contents and in-vitro release study show liquisolid compact exhibited higher percentage of drug release than conventional and marketed tablets because of due to increase in wetting properties and surface availability for dissolution
      PubDate: Dec 2013
       
  • Clinical Correlation of Metabolic Syndrome in Indian Type-2 Diabetics
           Patients with Their Socioeconomic Status under Different Age Group

    • Abstract: Publication date:  Dec  2013
      Source:Advances in Diabetes and Metabolism  Volume  1  Number  3  Manoj Kumar Upadhyay   The metabolic syndrome is a complex condition in which numerous aspects of normal metabolism are perturbed. The syndrome represents a cluster of the major risk factors for cardiovascular disease i.e. obesity, insulin resistance / hyperinsulinemia, impaired glucose tolerance / diabetes, dyslipidemia and hypertension. The syndrome is also described by a procoagulant state that is attributed, in part, to an elevation in circulating lipoprotein, fibrinogen and plasminogen activator inhibitor one levels. This in turn contributes to the metabolic abnormalities that lead to cardiovascular disease. Several hypothesis have been proposed for the etiology of the metabolic syndrome, and the potential role of insulin resistance, leptin resistance, and other disturbances as major contributing factors. Hyperinsulinemia and insulin resistance are predictors of type 2 diabetes and are key factors in the development of the metabolic syndrome. A survey was conducted to study the clinical correlation of metabolic syndrome in Indian type –2 diabetic patients with their socioeconomic status (high income group, middle income group & low income group) under different age group (upper age group, middle age group & low income group) in western Uttar Pradesh, India. Four hundred five type 2 diabetic patients aged 52 ±17 year including 215 (53.09%) males and 190 ( 46.91%) females were surveyed for this purpose. Of these hypertension & diabetics were simultaneously diagnosed in 196 (48.39%) & 152 (37.53%) patients. Family history of these patients showed the occurrence of diabetes , hypertension & concurrent hypertension with diabetes mellitus in about 59 (14.0%), 56 (13.8%) & 77 (19.1%) respectively. The frequencies of individual component of the metabolic syndrome were as follows: dyslipidemia - 68.4%, systemic hypertension – 54.3% , obesity – 42.5% microalbuminuria – 44.9% & hyperuracemia 58.3% . Ischemic heart disease (myocardial infarction) occurs in – 2.4%. Of these 405 diabetic studies, 278(68.2%) had metabolic syndrome victims occurs in the high income group & the low income group.
      PubDate: Dec 2013
       
  • Use of a Subcutaneous Insulin Computerized GlucoStabilizer™ Program on
           Glycemic Control in the Intensive Care Setting: a Retrospective Data
           Analysis

    • Abstract: Publication date:  Aug  2013
      Source:Advances in Diabetes and Metabolism  Volume  1  Number  1  Serena Harris PharmD BCPS Sarah A. Nisly PharmD BCPS Laura Aykroyd PharmD BCPS Joni Carroll RN MSN CDE Brian Ulmer MD Michael Waddell MD Samuel Flanders MD and Rattan Juneja MBBS MD MRCP Background: Despite guidelines that recommend strongly against Sliding Scale Insulin (SSI) it continues to be the most commonly insulin regimen used in hospitals to treat hyperglycemia. In addition to being reactionary to a glucose that has already increased, SSI offers practical challenges in the randomness of the doses of insulin prescribed and often a disconnect with glucose testing that should be occurring in congruence to the insulin dosing. While many clinical trials have shown improved glycemic control in critical care patients receiving intravenous insulin; few studies have demonstrated the efficacy of subcutaneous (SQ) insulin in this setting. In this study, we have evaluated the safety and efficacy of SQ insulin administration utilizing a computerized program, the Clarian GlucoStabilizer™ Subcutaneous Program (CGS-SQ) in the intensive care unit (ICU). This program is designed to overcome some of the most common barriers of SQ insulin delivery, those of dose calculation and timing. Methods: A computerized SQ insulin delivery program -The Clarian GlucoStabilizer™ Subcutaneous Program (CGS-SQ)- was made available to ICU practitioners, facilitating standardized calculation of insulin doses and incorporating reminder alarms for blood glucose (BG) testing. This program used three defaults Insulin Sensitivity Factors (ISF) and Insulin to Carbohydrate Ratios (CR) to calculate insulin doses. Additionally, there is an option for practitioner determined ISF and ICR. Patients, aged ≥ 18 years, initiated on the CGS-SQ and admitted to the (ICU) were eligible for inclusion in this retrospective evaluation. Patients were divided into four groups based on initial insulin sensitivity factor (ISF) and carbohydrate ratio (CR). Three of the groups used a default ISF and CR; ISF 60, CR 15; ISF 30, CR 10 and ISF 15, CR 8. These groups were compared with those where the practitioner specified an individualized ISF and CR, referred to as PDS (practitioner defined setting). Primary endpoints included: mean glucose, time to target glucose, hyperglycemic and hypoglycemic events. Results: In the 1,384 patients identified, patients initiated with a predefined setting had lower mean glucose compared to patients with PDS (ISF 60, CR 15: 135 mg/dL vs. ISF 30, CR 10: 140 mg/dL vs. ISF 15, CR 8: 134 mg/dL vs. PDS: 143 mg/dL; p < 0.0001). Patients in the default settings had shorter time to target glucose and decreased incidence of hyperglycemia and hypoglycemia. Conclusions: Using a system of computerized prompts with standardization of insulin dose calculation, SQ insulin can be effectively used in the treatment of ICU patients to target BG of 100-150 mg/dL with minimal risk of hypoglycemia.
      PubDate: Aug 2013
       
  • The Impact of Diabetes Education Modality and Diabetes Type on
           Psychosocial Outcomes in Young Adults with Diabetes

    • Abstract: Publication date:  Aug  2013
      Source:Advances in Diabetes and Metabolism  Volume  1  Number  1  Heather Blume SeAnne Safaii Samantha Ramsay and Martha Raidl A four lesson diabetes curriculum and two discussion sessions, focusing on diabetes self-management (diet, medication, physical activity) were delivered via two educational modalities: 1) Traditional Face-to-Face (FTF) Classes and 2) Virtual Diabetes Education (VDE) Classes administered in the Second Life® virtual world. The purpose of the study was to 1) describe the psychosocial outcomes in young adults with type 1 and type 2 diabetes and 2) determine whether two types of educational modalities (FTF or VDE) impacted the psychosocial outcomes of young adults with diabetes. A convenience sample of young adults with diabetes (N=81), 18 to 28 years-old, completed pre and post psychosocial surveys that measured levels of depression, self-efficacy, and social support. Multivariate and univariate analyses of variance identified differences in psychosocial outcomes. Overall, 29.9% of young adult participants reported depressive symptoms at the beginning of the study, and those with type 2 diabetes had higher rates of depressive symptoms (44.4%) than participants with type 1 diabetes (26.6%). Individuals with type 1 diabetes had a higher level of self-efficacy (p=.000) and more social support (p=.03) than their peers with type 2 diabetes. No statistically significant differences were apparent among type 1 and type 2 diabetes groups at post study measures. Face-to-Face participants had significantly greater (p=.02) gains in levels of diabetes self-efficacy. Participants in the FTF condition improved mean diabetes self-efficacy scores and participants in the VDE condition decreased mean diabetes self-efficacy scores. Session attendance was higher in the FTF condition (x=3.72, SD=2.23) than among participants assigned to the VDE condition (x=1.79, SD=1.82). Education and support programs should address differences in psychosocial outcomes based on both diabetes type and educational modality.
      PubDate: Aug 2013
       
  • Mipomersen: Pharmacology, Clinical Trials and Its Potential Role in
           Therapy

    • Abstract: Publication date:  Aug  2013
      Source:Advances in Diabetes and Metabolism  Volume  1  Number  1  Jeffery Evans and Dorothy Ann Shelton Mipomersen is a novel pharmacologic agent that utilizes anti-sense technology to reduce LDL in patients with very high LDL. The medication has been approved in the United States based on a series of small trials proving efficacy even with when added to traditional therapy. Safety concerns have been raised due to a potential for liver toxicity.
      PubDate: Aug 2013
       
  • Diabetic Ketoacidosis in an Obese Adolescent Diabetic Patient with
           Acanthosis Nigricans and without Autoantibodies. Is It Type 1.5
           Diabetes'

    • Abstract: Publication date:  Aug  2013
      Source:Advances in Diabetes and Metabolism  Volume  1  Number  1  Abhijit Swami Giridhari Kar Bijush Difoesa and S G Shyam Lakshman Over the years, adolescents have been diagnosed to be diabetic, the type of which do not fit into the classical types of diabetes – type 1 and type 2. These cases have been reported round the globe. They share features of both types of diabetes like obesity, acanathosis nigricans along with insulin resistance and can even have complications like Diabetic ketoacidosis. The present case study is about a newly diagnosed obese adolescent diabetic patient with acanthosis nigricans presenting with diabetic ketoacidosis who responded to standard treatment of Diabetic ketoacidosis. Subsequently, he was found to have low levels of C-peptide without insulin autoantibodies. Such cases have been variously referred as Double diabetes or 1.5 diabetes in literature and may constitute a subvariant of Diabetes.
      PubDate: Aug 2013
       
  • Young Adults with Diabetes Discuss Barriers and Solutions to Diabetes
           Management

    • Abstract: Publication date:  Aug  2013
      Source:Advances in Diabetes and Metabolism  Volume  1  Number  1  SeAnne Safaii Martha Raidl and Samantha Ramsay The purpose of this study was to identify perceived barriers young adults experience in diabetes self-management and possible strategies to overcome these barriers. Twenty two young adults, 18-28 years- old, with type 1 or type 2 diabetes attended three focus groups held in two north western states. Participants were asked to discuss barriers and strategies to help them manage their diabetes. The transcripts were coded and analyzed for themes. Four themes were identified: 1) lack of understanding of diet principles, medications and physical activity; 2) lack of support from family, friends and health care providers; 3) lack of resources to assist in managing blood sugar levels; and 4) participants reported the use of the internet and social networking as strategies for overcoming barriers. There are not a lot of materials developed for this age group. Most diabetes educational materials focus on children or adults. This qualitative study provides important insights from young adults regarding the development of educational materials and support systems to help them successfully manage their diabetes.
      PubDate: Aug 2013
       
  • Correlation between the Plasma Magnesium Levels and Glycated Haemoglobin
           in Sudanese Patients with Type 2 Diabetes Mellitus in Khartoum State

    • Abstract: Publication date:  Aug  2013
      Source:Advances in Diabetes and Metabolism  Volume  1  Number  1  Tilal Abd El-Hameed Seedahmed and Samia Mahdi Ahmed This is a cross sectional study aimed to evaluate the plasma levels of magnesium and HbA1C of (60) patients with type 2 diabetes mellitus and (40) apparently healthy (non – diabetic) volunteers as control group, the patients were chosen from different hospitals and specific centers. Age and sex of the test group were matched with the control group. The plasma levels of magnesium were measured using a spectrophotometer (Bio system Company reagents). HbA1C levels were measured using reagents and instruments from NycoCard company. Data was analyzed using SPSS. The results showed a significant reduction in the mean of the plasma levels of magnesium of the diabetic group when compared with the control group (p. value
      PubDate: Aug 2013
       
 
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
 
Home (Search)
Subjects A-Z
Publishers A-Z
Customise
APIs
Your IP address: 54.234.45.10
 
About JournalTOCs
API
Help
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-2016