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Publisher: Universitas Indonesia   (Total: 14 journals)   [Sort by number of followers]

Showing 1 - 14 of 14 Journals sorted alphabetically
ASEAN Marketing J.     Open Access   (Followers: 2)
Economics and Finance in Indonesia     Open Access   (Followers: 1)
eJurnal Kedokteran Indonesia     Open Access  
Indonesia Law Review     Open Access   (Followers: 5)
Indonesian Capital Market Review     Open Access   (Followers: 1)
J. of Dentistry Indonesia     Open Access  
Jurnal Ilmu Komputer dan Informasi     Open Access  
Kesmas : Public Health J.     Open Access   (Followers: 2)
Makara Hubs-Asia     Open Access  
Makara J. of Science     Open Access  
Masyarakat : Jurnal Sosiologi     Open Access  
Medical J. of Indonesia     Open Access  
South East Asian J. of Management     Open Access  
Wacana : J. of the Humanities of Indonesia     Open Access  
Journal Cover Medical Journal of Indonesia
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   ISSN (Print) 0853-1773 - ISSN (Online) 2252-8083
   Published by Universitas Indonesia Homepage  [14 journals]
  • The voice of Indonesian health scientists

    • Authors: Agus Rizal A.H. Hamid
      Pages: 1 - 2
      Abstract: Abstract [not available]
      PubDate: 2017-05-16
      DOI: 10.13181/mji.v26i1.1974
      Issue No: Vol. 26, No. 1 (2017)
       
  • Indonesia national health policy in the transition of disease burden and
           health insurance coverage

    • Authors: Nila F. Moeloek
      Pages: 3 - 6
      Abstract: Abstract [not available]
      PubDate: 2017-05-16
      DOI: 10.13181/mji.v26i1.1975
      Issue No: Vol. 26, No. 1 (2017)
       
  • High frequency of NAT2 slow acetylator alleles in the Malay population of
           Indonesia: an awareness to the anti-tuberculosis drug induced liver injury
           and cancer

    • Authors: Retno W. Susilowati, Kinasih Prayuni, Intan Razari, Syukrini Bahri, Rika Yuliwulandari
      Pages: 7 - 13
      Abstract: Background: Arylamine N-acetyltransferase 2 (NAT2) polymorphism was previously reported to have association with the risk of drug toxicities and the development of various diseases. Previous research on the Indonesian population, especially Javanese and Sundanese, showed that there were 33% NAT2 slow acetylator phenotype. The aim of this study was to map the NAT2 variation in the Malay ethnic to gain a deeper insight into NAT2 haplotypic composition in this ethnic.Methods: 50 healthy samples from the Indonesian Malay ethnic were obtained. They were interviewed about their ethnic backgrounds for the last three generations. DNA was extracted from peripheral blood and NAT2 genotyping was done using the PCR direct Sequencing. Data were compiled according to the genotype and allele frequencies estimated from the observed numbers of each specific allele. Haplotype reconstruction was performed using PHASE v2.1.1 software.Results: We found 7 haplotypes consisting of 6 SNPs and 14 NAT2 genotype variations in Indonesian Malay population. The most frequent allele was NAT2*6A (38%) which was classified as a slow acetylator allele. According to bimodal distribution, the predicted phenotype of the Malay population was composed of 62% rapid acetylator and 38% slow acetylator. According to trimodal distribution, the predicted phenotypes for rapid, intermediate and slow acetylators were 10%, 52% and 38% respectively.Conclusion: Our result indicates the presence of the allelic distribution and revealed the most frequent acetylator status and phenotype for the Indonesian Malay population. The result of this study will be helpful for future epidemiological or clinical studies and for understanding the genetic basis of acetylation polymorphism in Indonesia.
      PubDate: 2017-05-16
      DOI: 10.13181/mji.v26i1.1563
      Issue No: Vol. 26, No. 1 (2017)
       
  • TMEPAI genome editing in triple negative breast cancer cells

    • Authors: Bantari W.K. Wardhani, Meidi U. Puteri, Yukihide Watanabe, Melva Louisa, Rianto Setiabudy, Mitsuyasu Kato
      Pages: 14 - 8
      Abstract: Background: Clustered regularly interspaced short palindromic repeats/CRISPR-associated 9 (CRISPR/Cas9) is a powerful genome editing technique. It consists of RNA-guided DNA endonuclease Cas9 and single guide RNA (gRNA). By combining their expressions, high efficiency cleavage of the target gene can be achieved, leading to the formation of DNA double-strand break (DSB) at the genomic locus of interest which will be repaired via NHEJ (non-homologous end joining) or HDR (homology-directed repair) and mediate DNA alteration. We aimed to apply the CRISPR/Cas9 technique to knock-out the transmembrane prostate androgen-induced protein (TMEPAI) gene in the triple negative breast cancer cell line.Methods: Designed gRNA which targets the TMEPAI gene was synthesized, annealed, and cloned into gRNA expression vector. It was co-transfected into the TNBC cell line using polyethylenimine (PEI) together with Cas9-GFP and puromycin resistant gene vector. At 24-hours post-transfection, cells were selected by puromycin for 3 days before they were cloned. Selected knock-out clones were subsequently checked on their protein levels by western blotting.Results: CRISPR/Cas9, a genome engineering technique successfully knocked-out TMEPAI in the Hs578T TNBC cell line. Sequencing shows a frameshift mutation in TMEPAI. Western blot shows the absence of TMEPAI band on Hs578T KO cells.Conclusion: TMEPAI gene was deleted in the TNBC cell line using the genomic editing technique CRISPR/Cas9. The deletion was confirmed by genome and protein analysis.
      PubDate: 2017-05-16
      DOI: 10.13181/mji.v26i1.1871
      Issue No: Vol. 26, No. 1 (2017)
       
  • The suppression of manganese superoxide dismutase decreased the survival
           of human glioblastoma multiforme T98G cells

    • Authors: Novi S. Hardiany, Mohamad Sadikin, Nurjati Siregar, Septelia I. Wanandi
      Pages: 19 - 25
      Abstract: Background: Glioblastoma multiforme (GBM) is a primary malignant brain tumor which has poor prognosis. High incidence of oxidative stress-based therapy resistance could be related to the high antioxidant status of GBM cells. Our previous study has reported that manganese superoxide dismutase (MnSOD) antioxidant expression was significantly higher in high grade glioma than in low grade. The aim of this study was to analyze the impact of MnSOD suppression toward GBM cell survival.Methods: This study is an experimental study using human glioblastoma multiforme T98G cell line. Suppression of MnSOD expression was performed using in vitro transfection MnSOD-siRNA. The MnSOD expression was analyzed by measuring the mRNA using real time RT-PCR, protein using ELISA technique, and specific activity of enzyme using inhibition of xantine oxidase. Concentration of reactive oxygen species (ROS) intracellular was determined by measuring superoxide radical and hydrogen peroxide. Cell survival was analyzed by measuring viability, proliferation, and cell apoptosis.Results: In vitro transfection of MnSOD-siRNA suppressed the mRNA, protein, and specific activity of MnSOD. This treatment significantly increased the concentration of superoxide radical; however, it did not influence the concentration of hydrogen peroxide. Moreover, viability MnSOD-suppressing cell significantly decreased, accompanied by increase of cell apoptosis without affecting cell proliferation.Conclusion: The suppression of MnSOD expression leads to decrease glioblastoma multiforme cell survival, which was associated to the increase of cell apoptotic.
      PubDate: 2017-05-16
      DOI: 10.13181/mji.v26i1.1511
      Issue No: Vol. 26, No. 1 (2017)
       
  • Effectiveness of combined laser-puncture and conventional wound care to
           accelerate diabetic foot ulcer healing

    • Authors: Adiningsih Srilestari, Irma Nareswari, Christina Simadibrata, Tri J.E. Tarigan
      Pages: 26 - 34
      Abstract: Background: Impaired wound healing is a common complication of diabetes. It has complex pathophysiologic mechanisms and often necessitates amputation. Our study aimed to evaluate the effectiveness of combined laser-puncture and conventional wound care in the treatment of diabetic foot ulcers.Methods: This was a double-blind controlled randomized clinical trial on 36 patients, conducted at the Metabolic Endocrine Outpatient Clinic, Cipto Mangunkusumo Hospital, Jakarta, between May and August 2015. Stimulation by laser-puncture (the treatment group) or sham stimulation (the control group) were performed on top of the standard wound care. Laser-puncture or sham were done on several acupuncture points i.e. LI4 Hegu, ST36 Zusanli, SP6 Sanyinjiao and KI3 Taixi bilaterally, combined with irradiation on the ulcers itself twice a week for four weeks. The mean reduction in ulcer sizes (week 2–1, week 3–1, week 4–1) were measured every week and compared between the two groups and analyzed by Mann-Whitney test.Results: The initial median ulcer size were 4.75 (0.10–9.94) cm2 and 2.33 (0.90–9.88) cm2 in laser-puncture and sham groups, respectively (p=0.027). The median reduction of ulcer size at week 2–1 was -1.079 (-3.25 to -0.09) vs -0.36 (-0.81 to -1.47) cm2, (p=0.000); at week 3–1 was -1.70 (-3.15 to -0.01) vs -0.36 (-0.80 to -0.28) cm2, (p=0.000); and at week 4–1 was -1.22 (-2.72 to 0.00) vs -0.38 (-0.74 to -0.57) cm2, (p=0.012).Conclusion: Combined laser-puncture and conventional wound care treatment are effective in accelerating the healing of diabetic foot ulcer.
      PubDate: 2017-05-16
      DOI: 10.13181/mji.v26i1.1401
      Issue No: Vol. 26, No. 1 (2017)
       
  • Clinical characteristics of acute respiratory distress syndrome survived
           patients at a tertiary hospital in Jakarta

    • Authors: Zulkifli Amin, Fitriana N. Rahmawati, Chrispian O. Mamudi, Astrid P. Amanda
      Pages: 35 - 9
      Abstract: Background: While a good deal of research on characteristic the different characteristics between surviving and dying patient with ARDS has been conducted globally, such research is scarce in developing countries. This study aimed to obtain clinical profile of ARDS survivors during hospitalization.Methods: This was a prospective, observational study conducted at a tertiary hospital in Jakarta from October 2015 to April 2016. Primary data was collected from ARDS patients based on Berlin Definition admitted to emergency room, ICU, HCU, ICCU, and all other wards. The patients were followed until they discharged. We only included survivors on the analysis. Descriptive analysis was done using SPSS 21.0.Results: A total of 43 patients were survived during study period. The majority were below 65 years of age (69.8%) and were male (53.5%). ARDS was mainly mild in severity (62.8%) and early onset (55.8%). Sepsis was the most common causes of ARDS (97.7%). Most of the patients had comorbidities (74.4%). Majority of the patients had APACHE II score <20 (77.3%) with mean 15.6±4.8. The mean of albumin was 2.9±0.6 and the median of procalcitonin was 3 (0.1-252.3.Conclusion: The clinical profile of ARDS survivors in our study were mostly similar with other studies conducted in developed and other developing countries.
      PubDate: 2017-05-16
      DOI: 10.13181/mji.v26i1.1470
      Issue No: Vol. 26, No. 1 (2017)
       
  • The accuracy of Aziza‚Äôs scoring system in limited slice non-enhanced
           thoracic CT for the diagnosis of adult pulmonary tuberculosis

    • Authors: Aziza Icksan, Arif Faisal, Elisna Syahruddin
      Pages: 40 - 6
      Abstract: Background: Tuberculosis (TB) is still a major cause of morbidity and mortality in Indonesia. Thus, a fast and accurate method in diagnosing pulmonary TB (PTB) is needed, especially in adult smear-negative-TB cases. The purpose of this study was to determine the accuracy of a novel scoring system (Aziza’s score) using clinical data and characteristic abnormalities that are found in the limited slice non-enhanced thoracic CT.Methods: This was a prospective cross-sectional study. A limited slice non-enhanced thoracic CT was performed to establish a diagnosis of PTB in patients with suspected PTB and to assess the diagnostic value of the scoring system. A reference standard used in this study was the clinical expertise of two pulmonologists. The scoring system was analyzed using bivariate and multivariate Cox regression analysis.Results: 84 of 130 suspected PTB patients were diagnosed as PTB. They were diagnosed based on pulmonary characteristic abnormalities that were found in the limited slice non-enhanced thoracic CT. The scoring system was analyzed using bivariate and multivariate Cox regression analysis. The total scores which were equal to or more than 29 could diagnose PTB with the accuracy of 96.1% (95% CIs=91.3–98.3), sensitivity of 96.5% (95% CIs=90.1–98.8), and specificity of 95.6% (95% CIs=90.1–98.8), This novel scoring method was name as an Aziza’s scoring system.Conclusion: Aziza’s scoring system performed in the limited slice non-enhanced thoracic CT has a higher accuracy compared to the reference standard for the diagnosis of adult PTB.
      PubDate: 2017-05-16
      DOI: 10.13181/mji.v26i1.1432
      Issue No: Vol. 26, No. 1 (2017)
       
  • Clinical and ultrasound joint outcomes in severe hemophilia A children
           receiving episodic treatment in Indonesian National Hemophilia Treatment
           Center

    • Authors: Teny T. Sari, Novie A. Chozie, Djajadiman Gatot, Angela B.M. Tulaar, Rahayuningsih Dharma, Lugyanti Sukrisman, Saptawati Bardosono, Harry R. Achmad, Marcel Prasetyo
      Pages: 47 - 53
      Abstract: Background: Recurrent joint bleeds leading to arthropathy is the main problem in severe hemophilia children. This study aimed to investigate joint status in severe hemophilia A children receiving episodic treatment in Cipto Mangunkusumo Hospital, Jakarta.Methods: A cross-sectional study was conducted in Cipto Mangunkusumo Hospital as Indonesian National Hemophilia Treatment Center on children (4–18 years) with severe hemophilia A, who previously received episodic treatment, with no history of inhibitor factor VIII. Hemophilia Joint Health Score was evaluated according to HJHS version 2.1 2011. Joint ultrasonography was done for six index joints (bilateral elbows, knees and ankles) using Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) methods. Data of age of first joint bleed, number of target joints and inhibitor factor VIII were obtained from the Pediatric Hemophilia Registry and medical records.Results: There were 59 subjects aged 4 to 18 years. Twenty-nine out of 59 (49.2%) subjects experienced first joint bleed before of 2 years of age. The most common of joint bleeds was a right ankle. Mean total HJHS was 8.71±8.73. Subjects aged 4–10 years showed lower HJHS (4.6±3.7) as compared to subjects aged >10–18 years (12.3±10.3), p<0.001; 95% CI=4.9–13. Mean HEAD-US scores in subjects aged 4–10 years (18.7±5.6) was lower than in subjects aged >10–18 years (28±7.9), p<0.001, 95% CI= -12.9–-5.6.Conclusion: HJHS and HEAD-US scores of severe hemophilia A children receiving episodic treatment aged 4–10 years are lower compared to subjects aged >10–18 years, indicating more severe joint destruction in older children and progressivity of joint damage over time. It is important to start prophylactic treatment to prevent progressivity of joint damage.
      PubDate: 2017-05-16
      DOI: 10.13181/mji.v26i1.1494
      Issue No: Vol. 26, No. 1 (2017)
       
  • Chlorhexidine-alcohol versus povidone-iodine as preoperative skin
           preparation to prevent surgical site infection: a meta-analysis

    • Authors: Tasya Anggrahita, Aditya Wardhana, Gentur Sudjatmiko
      Pages: 54 - 61
      Abstract: Background: Surgical site infection remains substantial problems to surgeons and patients as it increases the morbidity, mortality, length of stay, hospital cost, rate of re-admission, and rate of re-surgery. This study aims to compare the use of chlorhexidine-alcohol versus povidone-iodine for preoperative skin preparation to prevent surgical site infection.Methods: The literature search was conducted through the PubMed database on November 2015. Included studies were RCTs with the year of publication up to 2015 which compared the use of chlorhexidine-alcohol versus povidone-iodine in its effectiveness reducing surgical site infection in adult patients. The quality of the study was assessed using Jadad Score. A meta-analysis was conducted in the included study to obtain a pooled estimate of the effect size. The evidence of heterogeneity and publication bias was also assessed.Results: Six RCTs with a total of 2,080 patients were included in the meta-analysis. It showed that the use of chlorhexidine-alcohol was associated significantly with fewer SSIs (pooled risk ratio=0.60 (95% CI=0.45-0.79)) and fewer positive skin culture results (pooled risk ratio, RR=0.38 (95% CI=0.28-0.51)) compared with povidone iodine.Conclusion: Preoperative skin antisepsis with chlorhexidine is more effective than povidone-iodine in preventing surgical site infection.
      PubDate: 2017-05-16
      DOI: 10.13181/mji.v26i1.1388
      Issue No: Vol. 26, No. 1 (2017)
       
  • Association between public knowledge regarding antibiotics and
           self-medication with antibiotics in Teling Atas Community Health Center,
           East Indonesia

    • Authors: Kurniawan Kurniawan, Jimmy Posangi, Nancy Rampengan
      Pages: 62 - 9
      Abstract: Background: Self-medication with antibiotics increases the risk of resistance, which leads to higher morbidity and mortality. The community plays an important role in preventing and controlling the spread of antibiotic resistance. This study aims to determine factors associated with antibiotics self-medication practices in the community, which are the key to developing effective intervention programs.Methods: This cross-sectional study was conducted between September and October 2015 at Teling Atas Community Health Center in Wanea, a sub-district of East Indonesia region. Data was collected by a questionnaire-guided interview. There were 35 questions which cover respondent demographics, antibiotic use, and respondents’ knowledge about antibiotics. Logistic regression was used to analyze the association between self-medication with antibiotics and respondents’ level of knowledge as well as other factors.Results: Among 400 respondents, there were 240 (60%) who had used antibiotics within 6 months prior to the interview and 180 (45.0%) who had self-medicated. Wounds or skin diseases (32.2%) were main reasons for self-medication. The majority of respondents self-medicated on their own initiatives (70.6%) and purchased antibiotics in pharmacies (52.2%). The mean score for respondent knowledge about antibiotic was categorized as “moderate” (score 7.14±2.49). Respondents with lower knowledge scores had higher probabilities to self-medicate with antibiotics than those with higher scores (OR= 16.86; 95% CI= 4.25–66.83).Conclusion: Self-medication practices with antibiotics in this study are associated with age, family income, and knowledge. Since poorer knowledge about antibiotics is associated with a higher probability of self-medication with antibiotics, education programs to improve public awareness are needed.
      PubDate: 2017-05-16
      DOI: 10.13181/mji.v26i1.1589
      Issue No: Vol. 26, No. 1 (2017)
       
  • Association between obesity and behavioral/emotional disorders in primary
           school-aged children: a cross-sectional study

    • Authors: Clarissa J. Aditya, Rini Sekartini
      Pages: 70 - 5
      Abstract: Background: Obesity in children can increase the risks of various chronic diseases. Mental disorders associated with obesity in children include: depression, anxiety, low self-esteem, hyperkinetic disorders, and increased aggressiveness. This relationship is estimated due to vulnerable genetic expressions in obese individuals. This study aimed to find the association between obesity and behavioral/emotional disorder in primary school-aged children.Methods: This cross-sectional study was conducted on 384 children at Menteng 1 Elementary School, Jakarta from July to September 2015. The study was conducted to find the association between the children’s nutritional status and behavioral/emotional disorders screened by the 17-item Pediatric Symptom Checklist (PSC-17). Chi square analysis was applied in this study.Results: The prevalence of obese children at Menteng 1 Elementary School, Jakarta reached 23.2%, which is higher than Jakarta’s prevalence (14%). 8.7% of the subjects were obese and 13.6% of them were having behavioral/emotional disorders. 20.0% of the obese subjects had behavioral/emotional disorders. The prevalence was higher for internalizing sub-scale, which was consistent with other studies. Association between obesity and behavioral/emotional disorders was significant for externalizing sub-scale (p=0.036). Externalizing problems caused by obesity might be affected by the social stigma of their peer group. However, obesity in children did not have a statistically significant relationship in internalization sub-scale, attention, and PSC-17 total score (p>0.05). No significant associations towards those sub-scales were thought to be influenced by other factors, playing a role in causing mental disorders in children.Conclusion: In general, obesity was not associated with behavioral and emotional disorders in children, but obesity was related to externalizing behavioral/emotional disorders.
      PubDate: 2017-05-16
      DOI: 10.13181/mji.v26i1.1564
      Issue No: Vol. 26, No. 1 (2017)
       
  • Reducing severe spasticity in cerebral palsy following meningoencephalitis
           by botulinum toxin

    • Authors: Prastiya I. Gunawan, Darto Saharso
      Pages: 76 - 80
      Abstract: A 3-year-old boy diagnosed with diplegic cerebral palsy had received Botulinum toxin injection to reduce severe spasticity. There was an improvement of muscles tone and motor function including better ability of limb flexion of the knees and hip, adduction of the hip, flexion of the toes, and plantar flexion of the foot. No side effect was observed after the procedure.
      PubDate: 2017-05-16
      DOI: 10.13181/mji.v26i1.1297
      Issue No: Vol. 26, No. 1 (2017)
       
 
 
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