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Publisher: Universitas Indonesia   (Total: 14 journals)   [Sort by number of followers]

Showing 1 - 14 of 14 Journals sorted alphabetically
ASEAN Marketing J.     Open Access   (Followers: 3)
Economics and Finance in Indonesia     Open Access   (Followers: 1)
eJurnal Kedokteran Indonesia     Open Access  
Indonesia Law Review     Open Access   (Followers: 5)
Indonesian Capital Market Review     Open Access   (Followers: 1)
J. of Dentistry Indonesia     Open Access  
Jurnal Ilmu Komputer dan Informasi     Open Access  
Kesmas : Public Health J.     Open Access   (Followers: 2)
Makara Hubs-Asia     Open Access   (Followers: 1)
Makara J. of Science     Open Access  
Masyarakat : Jurnal Sosiologi     Open Access  
Medical J. of Indonesia     Open Access   (Followers: 1)
South East Asian J. of Management     Open Access  
Wacana : J. of the Humanities of Indonesia     Open Access  
Journal Cover Medical Journal of Indonesia
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  This is an Open Access Journal Open Access journal
   ISSN (Print) 0853-1773 - ISSN (Online) 2252-8083
   Published by Universitas Indonesia Homepage  [14 journals]
  • Prospect of alternative therapies to kidney transplantation

    • Authors: Jeanne A. Pawitan
      Pages: 167 - 8
      Abstract: [no abstract available]
      PubDate: 2017-11-27
      Issue No: Vol. 26, No. 3 (2017)
       
  • The effects of quercetin on oxidative stress and fibrosis markers in
           chronic kidney disease rat model

    • Authors: Kamalia Layal, Ika S. Perdhana, Melva Louisa, Ari Estuningtyas, Vivian Soetikno
      Pages: 169 - 77
      Abstract: Background: Oxidative stress may play a role in the pathogenesis of (CKD), Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor involved in cell defense mechanism against oxidative stress. In this study, we examined the effect of quercetin, a polyphenplic antioxidant anti fibrosis compund in fruits and vegetables, on the 5/6 nephrectomy-induced CKD progression model rats through modulation of Nrf2 expression.Methods: Male Sprague-Dawley rats were randomly divided into normal control group (C), untreated 5/6 nephrectomy (Nx), quercetin-treated 5/6 nephrectomy (100 mg/kgBW/day orally) (NxQ), and captopril-treated 5/6 nephrectomy (10 mg/kgBW/day orally) (NxK) for 8 weeks. At the end of study, all animals were sacrified. Urine, blood, and kidney tissues were taken for examination of proteinuria, plasma creatinine, urea, malondialdehyde (MDA), glutathione peroxidase (GPx) activity, Nrf2, Keap1, heme oxygenase-1 (HO-1) expressions, and renal fibrosis.Results: Quercetin administration did not affect the level of protein in urine, plasma creatinine, and urea. However, it tended to reduce the level of MDA, increase GPx activity, Nrf2, Keap1, and HO-1 expression as well as the degree of fibrosis.Conclusion: In 5/6 nephrectomized rats, quercetin tended to ameliorate the level of MDA, GPx activity, Nrf2, Keap1, and HO-1 expression. In addition, quercetin tended to decrease the degree of fibrosis in the remnant kidney.
      PubDate: 2017-11-27
      Issue No: Vol. 26, No. 3 (2017)
       
  • Knock-out transmembrane prostate androgen-induced protein gene suppressed
           triple-negative breast cancer cell proliferation

    • Authors: Bantari W.K. Wardhani, Meidi U. Puteri, Yukihide Watanabe, Melva Louisa, Rianto Setiabudy, Mitsuyasu Kato
      Pages: 178 - 82
      Abstract: Background: Triple negative breast cancer (TNBC) tends to grow more rapidly and has poorer prognosis compared to others. High expression of transmembrane prostate androgen-induced protein (TMEPAI) correlates with poor prognosis in TNBC patients. However, the mechanistic role of TMEPAI in tumorigenic remains unknown. This study aimed to knock-out TMEPAI in TNBC cell line to determine its function further in cells proliferation.Methods: CRISPR-Cas9 has been used previously to knock-out TMEPAI in Hs857T TNBC cell line. Hs587T TNBC parental cell line (wild-type/WT) and TMEPAI knock out Hs 586T cell lines were cultured in Dulbecco’s modified eagle medium (DMEM) supplemented with 10% fetal bovine serum, 1% penicillin-streptomycin and amphotericin B. Both cell lines were seeded in 24-well plates and counted every two days, then proliferation rates were plotted. Afterwards, total RNA were isolated from the cells and Ki-67, and TGF-β mRNA expression levels as proliferation markers were determined.Results: Cell proliferation rates as displayed in growth curve plots showed that WT-TMEPAI cell line grew more rapidly than KO-TMEPAI. In accordance, mRNA expression levels of  Ki-67 and TGF-β  were significantly decreased KO-TMEPAI as compare to TMEPAI-WT.Conclusion: Knock-out of TMEPAI attenuates cell proliferation in TNBC.
      PubDate: 2017-11-27
      Issue No: Vol. 26, No. 3 (2017)
       
  • Permanent flame-blunted monofilament of middle cerebral artery occlusion
           technique for ischemia stroke induction in animal models

    • Authors: Yetty Ramli, Ahmad S. Alwahdy, Mohammad Kurniawan, Berry Juliandi, Puspita E. Wuyung, Yayi D.B. Susanto
      Pages: 183 - 9
      Abstract: Background: Rat is the most frequently used animal for ischemic stroke studies. Recently, middle cerebral artery occlusion (MCAO) by introducing various types of surgical monofilament intraluminally has been widely used, with their advantages and disadvantages. For permanent occlusion, problems with mortality in rats are higher than transient. In this study, we used permanent occlusion using modified monofilament by flaming on its tip which may reduce mortality rate, so that chronic phase of stroke can be learned extensively.Methods: Three male Sprague-Dawley rats underwent permanent MCAO. The flame-blunted monofilament was introduced through common carotid artery. Hematoxylin eosin histopathology confirmation and functional assessment post-stroke induction were then evaluated.Results: Evaluation was conducted on 3 rats in different time post-stroke induction (48 hours, 72 hours, and 3 weeks). Using histopathological examination, the infarction was proved in all 3 rats showing red neurons, perivascular edema and neutrophil spongiosis, in infarct and peri-infarct area. The changes in histopathology showed spongiosis were more dominant in 3 week-post-MCAO rats. On the other hand, red neurons and perivascular edema were less compared to 48 and 72-hour-post-MCAO rats.Conclusion: Flame–blunted monofilament showed its efficacy in producing infarct area. The advantages of this technique are easy to perform with simple and less expensive modification of the monofilament. Conducting successful permanent occlusion with less mortality rate will give chances to do further research on stroke in chronic phase and its effect on novel treatment.
      PubDate: 2017-11-27
      Issue No: Vol. 26, No. 3 (2017)
       
  • Cryptosporidium spp. and rotavirus gastroenteritis and change of incidence
           after rotavirus vaccination among children in Raparin Pediatrics Hospital,
           Erbil, Iraq

    • Authors: Sally S. Azeez, Hadi M. Alsakee
      Pages: 190 - 7
      Abstract: Background: Watery diarrhea is the most common medical problem among infants and young children, caused by different microbial etiology including Cryptosporidium spp. and rotavirus, which are usually misdiagnosed in conventional stool test. This study aimed to investigate the incidence of Cryptosporidium and rotavirus gastroenteritis among children in Erbil as well as evaluate the efficacy of rotavirus vaccination procedure applied in Erbil.Methods: Fecal specimens were collected from 400 children (boys and girls), aged one month to five years old, who attended Raparin Pediatrics Hospital in Erbil complaining from diarrhea, between January to August 2014. Modified Ziehl Neelsen technique and nested PCR were used for detection of cryptosporidiosis while rotavirus infection was detected by rapid CerTest.Results: Rate of detection of cryptosporidiosis was remarkably higher using PCR than Ziehl-Neelsen stain (0% versus 6%), and the infection was slightly higher among boys (6.25% vs 5.55%) and children ≤2 years (11.7%). The peak of infection reached during spring season (March and April) (9.5%). The detection rate of rotavirus was 32.0%, which was slightly higher among males (34.4% vs 30.0%) and in children between one to three years old (39.3%). The highest detection rate (38.6%) was recorded during winter season (January and February). The infection was significantly higher among non-vaccinated children (65.9% vs 14.1%; p<0.05).Conclusion: The incidence of cryptosporidiosis is declining. However, rotavirus gastroenteritis was relatively high among young children in Erbil. Rotateq vaccine significantly reduced the incidence of rotavirus infection.
      PubDate: 2017-11-27
      Issue No: Vol. 26, No. 3 (2017)
       
  • High preterm birth at Cipto Mangunkusumo Hospital as a national referral
           hospital in Indonesia

    • Authors: Ali Sungkar, Adly N.A. Fattah, Raymond Surya, Budi I. Santoso, Ivica Zalud
      Pages: 198 - 203
      Abstract: Background: Preterm birth is the leading direct that causes neonatal death. Indonesia was listed as one of the countries with the greatest number of preterm birth in 2010. This study aims to identify the prevalence and the potential risk factors of preterm birth among women underwent delivery in Cipto Mangunkusumo Hospital, an Indonesian national reference hospital.Methods: This retrospective cohort study involved 2,612 women who delivered between January and December 2013. Any clinical data which related to the potential risk factors and outcomes were recorded. The data were managed using chi-square for bivariate analysis and t-test or Mann-Whitney for numerical data followed by multiple logistic regression for multivariate analysis in SPSS version 20.0.Results: Preterm birth affected 1,020 of 2,616 pregnancies (38.5%). Non-booked patients increased nearly twice risk for preterm delivery (OR 1.89, 95% CI 1.37–2.61). While women with singleton pregnancy (OR 0.17, 95% CI 0.12–0.25), head presentation (OR 0.75, 95% CI 0.63–0.89), and regular ANC (OR 0.67, 95% CI 0.54–0.84) had lower risk for preterm birth. Apgar score, birthweight, and mode of delivery were significantly different between the pre-term group and the full-term group.Conclusion: Prevalence of preterm birth in Cipto Mangunkusumo Hospital was approximately 2.5 times higher compared to the national number. Several factors reducing preterm birth rate include singleton pregnancy, head presentation, and regular ANC.
      PubDate: 2017-11-27
      Issue No: Vol. 26, No. 3 (2017)
       
  • The effect of Bifidobacterium animalis lactis HNO19 supplementation among
           pregnant and lactating women on interleukin-8 level in breast milk and
           infant’s gut mucosal integrity

    • Authors: Naomi E.F. Dewanto, Agus Firmansyah, Ali Sungkar, Nani Dharmasetiawani, Sudigdo Sastroasmoro, Siti B. Kresno, Rulina Suradi, Saptawati Bardosono, Dwi Prasetyo
      Pages: 204 - 11
      Abstract: Background: Newborn’s gut mucosal is not fully developed, therefore infants are prone to diarrhea. Probiotic supplementation is known to induce the gut mucosal maturity. This study aimed to identify whether probiotics supplementation among pregnant women since the third trimester would increase the infant’s gut mucosal integrity.Methods: A double-blind, randomized clinical trial was conducted to understand the potential effect of probiotic supplementation on the level of probiotics and IL-8 in breastmilk, urine IFABP, faecal α-1-antytripsin (AAT) and calprotectin in infant’s at birth (V0) and three-months old (V3). A single strain of Bifidobacterium lactis animalis HNO19 (known as DR10) was used since it was not the resident bacteria. The study was held at Budi Kemuliaan Hospital and its satellite clinics from December 2014 to December 2015.Results: About 14% (5/35) and 20% (7/35) of the subjects had DR10 in the breastmilk’s colostrum and at the age of 3-months. The median values of IL-8 in the probiotic group vs the placebo group at V0 and V3 were 2810,1 pg/mL vs 1516.4 pg/mL (p=0.327) and 173.2 pg/mL vs 132.7 pg/mL (p=0.211) respectively. IFABP level 211.7 ng/mL vs 842.5 ng/mL (p=0.243) and 25.3 ng/mL vs 25.1 ng/mL (p=0.466); AAT 136.2 mg/dL vs 148.1 mg/dL (p=0.466) and 24 mg/mL vs 29.72 mg/mL (p=0.545); Calprotectin 746.8 ng/mL vs 4645.2 ng/mL (p=0.233) and 378.6 ng/mL vs 391.3 ng/mL (p=0.888).Conclusion: Probiotic DR10 given to pregnant women since the 3rd trimester can be found in colostrum and 3-months breastmilk. However, it did not affect the level of other probiotics or IL-8 and the gut mucosal integrity.
      PubDate: 2017-11-27
      Issue No: Vol. 26, No. 3 (2017)
       
  • The influence of water intake on waiting time prior to uroflowmetry: a
           prospective, randomized, double-blind trial

    • Authors: Nur Rasyid, Donny E. Putra, Widi Atmoko, Adianti Khadijah, Dyandra Parikesit, Ponco Birowo
      Pages: 212 - 7
      Abstract: Background: In uroflowmetry examination, patients are usually instructed to intake a large volume of water and wait until the bladder is full. The association between the volume of water intake and the waiting time before uroflowmetry is unknown. The aim of this study is to investigate the relationship between the volume of water intake and the waiting time prior to uroflowmetry.Methods: This trial was designed as a randomized, researchers, caregivers and patients blinded, superiority trial with three parallel groups and primary endpoint of waiting time prior to the uroflowmetry study based on the volume of patients’ water intake. Randomization was performed by block randomization with a 1:1:1 allocation. Patients scheduled for uroflowmetry at the Urology Clinic of Cipto Mangunkusumo Hospital were enrolled from March 2013 until December 2013. The eligibility criteria were male patients with ages above 50 years and body mass index 18.5–24.9 kg/m2.Results: A total of 83 patients was randomly assigned into 3 study groups: 300 ml (28 patients), 400 ml (28 patients), and 500 ml (27 patients). All patients were included in final analysis. Mean waiting time were 85.1±59.8 min, 107.2±70.4 min, and 66±28.4 min for patients intake 300, 400, and 500 ml of water respectively (p=0.07). The final bladder volumes for three groups were statistically different (262.4±130.8 ml, 289.4±126.2 ml, 359.2±137 ml; p=0.02).Conclusion: The volume water intake of 300–500 ml did not affect waiting time before uroflowmetry. Increasing water intake at least 500 ml added the final bladder volume and shorter the waiting time.
      PubDate: 2017-11-27
      Issue No: Vol. 26, No. 3 (2017)
       
  • Diagnostic accuracy of magnetic resonance imaging in detecting anterior
           cruciate ligament injuries

    • Authors: Ashfaq Ahmed, Muhammad A. Razzaque, Muhammad Kaleem, Atiq U. Zaman, Rizwan Akram, Shahzad Javed
      Pages: 218 - 23
      Abstract: Background: The anterior cruciate ligament (ACL) stabilizes the joint during hyperextension and prevents anterior translation over femur. The objective of this study was to determine the diagnostic accuracy of magnetic resonance imaging (MRI) in detecting ACL injury by taking arthroscopy as gold standard in patients with traumatic knee injury.Methods: Patients fulfilling the study criteria were treated with clinical examination, MRI and then arthroscopy at the Department of Orthopedics and Spine in the Ghurki Trust Teaching Hospital, Lahore. The accuracy, sensitivity and specificity of MRI in diagnosing  the anterior cruciate ligament injury were calculated based on arthroscopic findings. All the data were analyzed using SPSS 17.0 version.Results: A total 185 patients were included. 91.1% were males and 8.9% were females with Mean age of 28.25±0.433. The accuracy of MRI in diagnosing the anterior cruciate ligament was 91.89%, with sensitivity of 93.33%, specificity of 85.71%, positive predictive value of 96.55% and the negative predictive value  of 75%.Conclusion: MRI is accurate and non-invasive modality for the assessment of ligamentous injuries. It can be used as a first line investigation to patients with suspicion of ACL injury.
      PubDate: 2017-11-27
      Issue No: Vol. 26, No. 3 (2017)
       
  • Serum specific IgE responses to inhalant allergens sensitization

    • Authors: Iris Rengganis, Suriani Alimuddin, Agus J. Susanto
      Pages: 224 - 8
      Abstract: Background: Serum specific immunoglobulin E (ssIgE) sensitization to common inhalant allergens has not been studied in Indonesia. This study aimed to evaluate specific IgE production of common inhalant allergens in patients with asthma and/or allergic rhinitis in Jakarta, Indonesia.Methods: This was a cross-sectional study in adult patients with respiratory allergy from September to December 2016 at Cipto Mangunkusumo Hospital, Jakarta. Patients were included if they showed at least one positive skin prick test (SPT) to environmental allergens. Serum specific IgE was assayed by using multiple allergosorbent methods. Inhalant allergens tested were dust mites, pollen, cockroach, animal dander, and mould. Serum IgE level more than 0.35 kU/L was considered positive.Results: One hundred subjects were enrolled (76% women). Dust mites made up 75% of sensitization, followed by cat/dog (31%), cockroach (27%), pollen (24%), and mould (6%). Almost all patients sensitized to cockroach, pollen, cat/dog epithelia and mould were also co-sensitized with dust mites. Twenty two percent of patients were negative to all tested allergens.Conclusion: IgE-sensitization to inhalant allergens varies widely in respiratory allergic patients. House dust and storage mites are the most common allergens. About one-fifth of the subjects did not show specific-IgE sensitization. Thus, this test should always be combined with SPT to diagnose allergy.
      PubDate: 2017-11-27
      Issue No: Vol. 26, No. 3 (2017)
       
  • Milestones of kidney transplantation in Indonesia

    • Authors: Chaidir A. Mochtar, Fekhaza Alfarissi, Adhitama A. Soeroto, Agus Rizal A.H. Hamid, Irfan Wahyudi, Maruhum B.H. Marbun, Arry Rodjani, Endang Susalit, Nur Rasyid
      Pages: 229 - 36
      Abstract: Although kidney transplantation in Indonesia has started since 1977, it has only covered less than 3% ESRD treatment methods. This indicates that the development of kidney transplantation program in Indonesia is still stagnant. Based on observation, the growth of kidney transplantation in Indonesia can be divided into several eras, which are: the birth of new treatment for ESRD era, the expected growth era, the first downfall, the stable period, the unstable period, the rebirth of kidney transplant era, and the explosive growth era. Many factors contribute to this issue including the government policy, the funding problems, the limited donor pool, the dissenting cultural views, the number of human resources, the need for multi-disciplinary approach, and the life-after-graft care. However, many improvements have been made to increase kidney transplantation i.e. the government support for opening new kidney transplant centers, the use of minimally invasive techniques, the development of pediatric kidney transplant, and National Insurance coverage for transplantation. These conditions are expected to improve the number of kidney transplantation in Indonesia.
      PubDate: 2017-11-27
      Issue No: Vol. 26, No. 3 (2017)
       
 
 
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