for Journals by Title or ISSN
for Articles by Keywords
help

Publisher: Badan Penelitian dan Pengembangan Kesehatan   (Total: 3 journals)   [Sort by number of followers]

Showing 1 - 3 of 3 Journals sorted alphabetically
Buletin Penelitian Kesehatan     Open Access   (Followers: 2)
Health Science J. of Indonesia     Open Access   (Followers: 1)
Media Penelitian dan Pengembangan Kesehatan     Open Access   (Followers: 1)
Journal Cover Health Science Journal of Indonesia
  [1 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2087-7021 - ISSN (Online) 2338-3437
   Published by Badan Penelitian dan Pengembangan Kesehatan Homepage  [3 journals]
  • The use of traditional health care among Indonesian Family

    • Authors: Nurhayati Nurhayati, Lucie Widowati
      Abstract: Abstrak Latar belakang: Penggunaan obat tradisional, pengobatan komplementer dan alternatif meningkat selama beberapa tahun terakhir. Alasan utama meningkatnya penggunaan obat tradisional adalah pasien mengambil pendekatan yang lebih proaktif untuk kesehatan mereka dan mencari berbagai bentuk perawatan. Penelitian ini bertujuan untuk mengidentifikasi faktor dominan yang berhubungan dengan pemanfaatan pelayanan kesehatan tradisional pada rumah tangga di Indonesia   Metode: Penelitian ini menggunakan data rumah tangga dari data Riskesdas tahun 2013. Analisis data menggunakan regresi cox untuk memperoleh faktor dominan yang berhubungan dengan pemanfaatan pelayanan kesehatan tradisional pada rumah tangga di Indonesia Hasil: Sebanyak 294.959 subjek pada penelitian ini. Proporsi subjek yang memanfaatkan pelayanan kesehatan tradisional adalah 30,4% (78.775/294.959). Faktor risiko dominan yang berhubungan dengan pemanfaatan pelayanan kesehatan tradisional adalah wilayah tempat tinggal, tingkat pendidikan, status pekerjaan, status ekonomi, dan ketersediaan pelayanan kesehatan. Dibandingkan dengan rumah tangga yang tinggal di pedesaan, rumahtangga yang berada di perkotaan lebih berpeluang 14% memanfaatkan pelayanan kesehatan tradsional. Rumah tangga yang tingkat pendidikannya lebih tinggi lebih berpeluang 85% memanfaatkan pelayanan kesehatan tradisional. Rumah tangga yang bekerja lebih berpeluang 18% memanfaatkan pelayanan kesehatan tradsional. Rumah tangga yang memiliki tingkat ekonomi yang tinggi lebih berpeluang 45% memanfaatkan pelayanan kesehatan tradisional. Rumah tangga yang mengetahui ketersediaan pelayanan kesehatan lebih berpeluang 32% memanfaatkan pelayanan kesehatan tradisional Kesimpulan: Rumah tangga yang tinggal di perkotaan, memiliki tingkat pendidikan menengah dan tinggi, bekerja, memiliki status ekonomi yang lebih tinggi, mengetahui ketersediaan pelayanan kesehatan, lebih berpeluang memanfaatkan pelayanan kesehatan tradisional   Kata kunci: pelayanan kesehatan tradisional, rumah tangga Indonesia   Abstract Background: The use of traditional medicine and complementary and alternative medicine has increased significantly over the past few years. The main reasons for the increasing use of traditional medicine is a growing trend for patients to take a more proactive approach to their own health and to seek out different forms of self-care. This study aimed to investigate the dominant risk factors that related to use of traditional health care among Indonesian family   Methods: The study used household data from 2013 National Health Survey Indonesia. Using cox regression, we then could present dominant risk factors that related to use of traditional health care among Indonesian family   Results: Total subjects had been analyzed were 294,959 subjects. The proportion of those who used of traditional health care were 30,4% (78,775/294,959). Dominant risk factors related to used of traditional health care were type area, level of education, employment status, level of economic, and knowing about the availability of health care. Compared with those who were in rural, those who were in urban had 14% more likely to used of traditional health care. Household who had higher education level had 85% more likely to used of traditional health care. Household who were employed had 18% more likely to used of traditional health care. Household who had higher economic level had 45% more likely to used of traditional health care. Furthermore, household who knowed about the availability of health care had 32% more likely to used of traditional health care. Conclusion: Household subjects who were in urban area, employed, had higher level of education and economic, knowed  the availability of health services were more likely to used of traditional health care   Keywords: traditional health care, household Indonesia
      PubDate: 2017-07-27
      Issue No: Vol. 8 (2017)
       
  • Flight hours of unplanned flight and other risk factors affecting exercise
           habit among commercial pilots in Indonesia

    • Authors: Citra Ariani
      Abstract: AbstrakLatar belakang: Kebiasaan melakukan latihan fisik antara lain berguna bagi kebugaran fisik serta kognitif, serta mencegah inkapasitasi akibat nyeri punggung bawah, kelelahan, dan penyakit kardiovaskular. Penelitian ini bertujuan untuk mengetahui gambaran kebiasaan latihan fisik pada pilot sipil di Indonesia serta faktor-faktor yang mempengaruhinya. Metode: Penelitian ini dilakukan dengan desain potong lintang menggunakan data sekunder dari Survey Terhadap Kebiasaan Hidup Sehat Pilot Sipil di Indonesia Tahun 2016. Pada penelitian ini, yang dianalisis adalah data pilot dengan lisensi CPL dan ATPL. Kebiasaan latihan fisik sesuai dengan rekomendasi latihan fisik American College of Sports Medicine (ACSM). Data yang diambil meliputi data demografi, pekerjaan, kepuasan hidup, indeks massa tubuh, dan lingkar pinggang. Analisis regresi Cox digunakan untuk menganalisis faktor-faktor dominan yang mempengaruhi kebiasaan latihan fisik. Hasil: Di antara 644 data pilot, terdapat 332 data yang memenuhi kriteria. Proporsi pilot sipil yang memiliki kebiasaan latihan fisik yang sesuai rekomendasi adalah 44%. Faktor dominan yang mempengaruhi latihan fisik adalah usia. Pilot sipil berusia 50 sampai 65 tahun memiliki kebiasaan latihan fisik 40% lebih rendah dibandingkan dengan pilot sipil berusia 20 – 29 tahun (risiko relatif suaian (RRa) 0,60; Interval Kepercayaan (IK) 95% 0,38 – 0,94; P 0,026). Sedangkan jam terbang di luar jadwal dan indeks massa tubuh yang berlebih nampaknya berpengaruh terhadap kebiasaan latihan fisik (secara berurutan: RRa 0,58; IK95% 0,30 – 1,13; P 0,112 dan RRa 0,79; IK95% 0,62 – 1,02; P 0,072). Kesimpulan: Usia, jam terbang di luar jadwal, dan IMT berlebih nampaknya berpengaruh terhadap kebiasan latihan fisik pada pilot sipil di Indonesia. Kata kunci: latihan fisik, jam terbang, pilot sipil, Indonesia Abstract Background: Physical exercise habit has some benefits, among others, for physical fitness and cognitive function, as well as preventing incapacitation events caused by low back pain, fatigue, dan cardiovascular diseases. The aim of this study was to find out the description of physical exercise habit among commercial pilot in Indonesia and its affecting factors. Method: This study was conducted with cross sectional design using secondary data from Healthy Lifestyle Survey of Commercial Pilot in Indonesia Year 2016. In this study, data of pilots with CPL and ATPL was analysed. Physical exercise habit was defined appropriately with American College of Sports Medicine (ACSM) recommendation. Data taken were demographic data, job factors, satisfaction of life, body mass index, and waist circumference. Cox regression analysis was used to analyse dominant factors which affect physical exercise habit. Results: Among 644 pilots’ data, there were 332 data met the criteria in this study. Proportion of commercial pilots who had appropriate exercise habit was 44%. Dominant factor which affecting exercise habit was age. Compared to pilots aged 20 to 29 years old, pilots aged 50 to 65 years old had 40% less likely to have exercise habit (adjusted relative aisk (RRa) 0.60; 95% Confidence Interval (CI) 0.38 – 0.94; P 0.026). Moreover, flight hours of unplanned flight and overweight were likely to affect physical exercise habit (consecutively aRR 0.58; 95%CI 0.30 – 1.13; P = 0.112 and aRR 0,79; IK95% 0,62 – 1,02; P 0,072). Conclusion: Age group, flight hours of unplanned flight and overweight were likely to affect exercise habit among commercial pilots in Indonesia. Key words: physical exercise, flight hours, commercial pilot, Indonesia.
      PubDate: 2017-07-26
      Issue No: Vol. 8 (2017)
       
  • Flight Hours in 7 Consecutive Days and Physical Exercise among the Civil
           Pilot in Indonesia

    • Authors: Harry Wicaksana
      Abstract: Abstrak Latar belakang Tidak tersedianya waktu merupakan salah satu hambatan melakukan latihan fisik yang sering dilaporkan di negara berkembang. Berdasarkan Peraturan Keselamatan Penerbangan Sipil bagian 121, jam terbang maksimal pilot sipil komersial dalam 7 hari terakhir adalah 30 jam. Oleh karena itu perlu dilakukan penelitian mengenai hubungan jam terbang 7 hari terakhir terhadap kebiasaan latihan fisik pada pilot sipil di Indonesia. Metode Penelitian potong lintang terhadap 600 orang pilot sipil yang melakukan pengujian kesehatan personil penerbangan di Balai Kesehatan Penerbangan pada bulan April 2016 dan memenuhi kriteria inklusi/ekslusi.  Data yang dikumpulkan yaitu karakteristik demografi, pekerjaan, kebiasaan olahraga, tinggi dan berat badan. Pengambilan data dilakukan dengan wawancara dan pemeriksaan fisik. Pilot dikategorikan memiliki kebiasaan latihan fisik sesuai rekomendasi ACSM apabila melakukan latihan fisik dengan intensitas sedang selama 150 menit per minggu atau latihan fisik dengan intensitas berat selama 75 menit per minggu. Hasil Jam terbang 7 hari terakhir merupakan faktor dominan terhadap kebiasaan latihan fisik. Jika dibandingkan dengan pilot dengan jam terbang 7 hari terakhir < 3,5 jam, maka pilot dengan jam terbang 7 hari terakhir 3,5-14 jam berisiko 24% lebih rendah memiliki kebiasaan latihan fisik sesuai [RRa= 0,76; p=0,032]. Simpulan Faktor risiko yang berpengaruh terhadap kebiasaan latihan fisik adalah jam terbang 7 hari terakhir. Kata kunci: Jam terbang 7 hari terakhir, kebiasaan latihan fisik, pilot sipil Indonesia  Background The most frequently reported barrier of doing physical exercise in developed countries is lack of time. Based on the Civil Aviation Safety Regulation part 121, the maximum working hour for commercial pilot in 7 consecutive days is 30 hours. The study objective is to identify the relation between flight hours in 7 consecutive days and the physical exercise habit among the civil pilots in Indonesia. Method A cross sectional study towards 600 civil pilots, who did their medical examination at the Aviation Medical Center, Jakarta and met the inclusion/exclusion criteria. The collected data were demographic and job characteristics, physical exercise habits, body weight, heights. The data was obtained through interview and physical examinations. Pilot was categorized as having an appropriate physical exercise habit if he/she spent 150 minutes of moderate intensity exercise per week or 75 minutes of vigorous intensity exercise per week. Results Flight hour in 7 consecutive days was a dominant factor to the physical exercise habit. Compared to the pilot who had flight hours in 7 consecutive days less than 3.5 hours, pilot who had flight hours in 7 consecutive days 3.5-14 were having less 24% risk of appropriate physical exercise [RRa= 0,76; p=0,032]. Conclusion Risk factor to the physical exercise habit among the civil pilot is flight hour in 7 consecutive days. Key words: Flight hours in 7 consecutive days, physical exercise, civil pilot in Indonesia.
      PubDate: 2017-07-26
      Issue No: Vol. 8 (2017)
       
  • Serologic observation and risk fact of yaws in Hamadi Public Health
           Center, Jayapura

    • Authors: Yuli Arisanti Sitanggang
      Abstract: Latar belakang: Penyakit frambusia masih menjadi masalah yang belum terselesaikan di Kota Jayapura, masih terdapat daerah kantong frambusia di Kota Jayapura. Penelitian ini bertujuan untuk mendapatkan data status secara serologi dan mengetahui data faktor risiko frambusia. Metode: digunakan dalam penelitian ini adalah pemeriksaan laboratorium standar yang digunakan dalam penelitian ini berupa uji Treponema pallidum haemagglutination (TPHA). Metode penelitian berupa deskriptif dengan desain cross sectional. Hasil: Penelitian ini mendapatkan faktor risiko frambusia seperti riwayat pernah mengalami frambusia memiliki potensi dua kali lebih besar untuk relaps serta perilaku hidup bersih dan sehat yang kurang dengan uraian : mandi jarang/tanpa menggunakan sabun berpotensi dua kali lebih besar menjadi frambusia, kebiasaan pakai handuk bergantian tiga kali lebih besar potensinya, kebiasaan jarang/tidak pakai sandal dua kali lebih besar potensinya. Kesimpulan: Mendapatkan data jumlah TPHA yang positif baik kasus dan kontak sejumlah 111 sampel. Penelitian ini mendapatkan data faktor risiko yang mempengaruhi kejadian frambusia di wilayah kerja Puskesmas Hamadi di Kota Jayapura seperti : -          riwayat pernah mengalami frambusia juga memiliki potensi empat kali lebih besar untuk relaps -          perilaku hidup bersih dan sehat yang kurang dengan uraian : Mandi jarang/tanpa menggunakan sabun berpotensi dua kali lebih besar menjadi frambusia, kebiasaan pakai handuk bergantian tiga kali lebih besar potensinya, kebiasaan jarang/tidak pakai sandal dua kali lebih besar potensinya. Abstract Background: Yaws still become unfinished problem in Jayapura City, there is still have enclave yaw’s disease in Jayapura. This study aimed to obtain data by serological prevalence and determine the risk factor data for yaws. The Treponema pallidum haemagglutination test (TPHA) was laboratory standard method which used in this study. Methods: The research was a descriptive research which conducted through a cross sectional design. Results: This research found that risk factors of yaws such history for being inexperienced to yaws also had potency up to two times greater for yaws to get relapsed, as well as with inadequate personal hygiene for the incidence of yaws, with description: bathing without using soap potentially three times greater potency to be susceptible to yaws, collective towels usage led to three times higher potency, habit; rarely/not wearing sandals led to two times higher potency to get infected by yaws. Conclusion: Obtaining data on the number of positive TPHA both cases and contact number of 111 samples. This research obtained the data of risk factors that affected the incidence of yaws in Puskesmas Hamadi, Jayapura such as:- History of being experienced yaws also had the potential to four times more likely to get relapsed - Less Clean and healthy life behavior that was with description: Bath rarely / without using soap could potentially be twice over to become yaws, custom-made towels alternately had three times greater in potency, the habit for being rarely / not wear sandal was two times greater potency
      PubDate: 2017-07-21
      Issue No: Vol. 8 (2017)
       
  • Polymorphism Analysis of the CoA (Coagulase) Gene in Isolates of
           Methicillin-Resistant Staphylococcus aureus with AluI Restriction Sites

    • Authors: Anita Dwi Anggraini, Eko Budi Koendhori, Hendro Pramono, Daniel Djoko Wahyono
      Abstract: Abstract: Analysis of the polymorphism of a gene is important to obtain early information in identifying genetic markers related to the characteristics to be seen. The RFLP method becomes one of the chosen methods because it can see polymorphism that can be detected by using the different fragments of DNA that have been cut by using certain endonuclease enzyme so that it is possible to describe the polymorphism of a gene. Application of RFLP in this study was devoted to see the coagulase gene polymorphism of methichillin-resistant S. aureus. Based on the description above, researcher was interested in conducting the analysis of CoA (coagulase) gene polymorphism with AluI restriction site of methicillin-resistant S. aureus isolates. The results of this study are aimed to be scientific information about the genetic variation of the coagulase gene of methicillin-resistant S. aureus, and as information in the management of diseases related to antibiotic resistance. This was a descriptive study intended to discover the coagulase gene polymorphism of methichillin-resistant S. aureus. The research was conducted in Microbiology Laboratory of Health Analyst Department, Surabaya, and Human Genetic Laboratory of Institute of Tropical Disease of Airlangga University Surabaya. Samples from this study was a collection of isolates of MRSA in Microbiology Laboratory of Dr. Soetomo Hospital Surabaya selected by using consecutive sampling. Based on the bacteriological examination, all of the samples were S. aureus and the results of amplification showed that PCR product (amplicon) of mecA and CoA gene from specific primers, that were 304 bp and 756 bp, had a positivity of 100%. The results of PCR-RFLP of CoA gene showed that all 25 samples underwent polymorphism which was divided into four RFLP patterns and the biggest one was RFLP I pattern (the one which was not digested by AluI restriction enzyme) with a proportion of 64%.
      PubDate: 2017-07-18
      Issue No: Vol. 8 (2017)
       
  • The Novel Genotype D8 of Measles Virus Detected in Indonesia in 2014

    • Authors: Subangkit Subangkit, Mursinah Mursinah, Rudi Hendro Putranto, Vivi Setiawaty
      Abstract: Background
      Measles is one of the most infectious human diseases and can cause serious illness, lifelong complications and death. Measles is still a public health problem since the measles outbreak still occurred throughout Indonesia. Virology surveillance following molecular epidemiology investigations has a major contribution to prevent measles outbreak. Previous studies have documented the presence of measles virus genotypes G2, G3 and D9 in Indonesia, and the other genotypes such as B3, D4, D5, D8 and H1 have been detected in neighboring countries. This study aims to characterize the measles virus that causing outbreak in Indonesia in 2014.
      Methods
      Seventy four urine specimens were collected from eight provinces and examined by one step RT-PCR and Sanger sequencing method. Sequencing analysis were conducted using Bioedit 7.1; DNA Star 7.0 and MEGA 5.0 software.
      Results
      The PCR results showed 34 out of 74 clinical specimens positive of measles virus. We found the genotype of 34 measles viruses belongs to genotype D8, D9 and G3.
      Conclusion
      The first measles genotype D8 has been detected from Indonesia in 2014 although other measles genotype still can be found in Indonesia.


      PubDate: 2017-07-18
      Issue No: Vol. 8 (2017)
       
  • Total working period and other risk factors related to eating protein
           foods habits among civil pilots in Indonesia

    • Authors: Indah Imelda Hutabarat
      Abstract: ABSTRAK Latar belakang: Kebiasaan makan protein yang berlebihan dapat menyebabkan penyakit ginjal dan hati serta meningkatkan risiko penyakit kardiovaskular yang dapat menyebabkan terjadinya inkapasitasi pada pilot. Tujuan penelitian ini adalah mengidentifikasi faktor sosiodemografi dan faktor lainnya terhadap kebiasaan makan protein berlebih pada pilot sipil di Indonesia. Metode: Penelitian potong lintang menggunakan data sekunder Survei kebiasaan makan, minum dan latihan fisik pada pilot  sipil di Indonesia 2016. Data yang dikumpulkan adalah karakteristik demografi, kebiasaan latihan fisik, pengetahuan, indeks massa tubuh dan karakteristik penerbangan. Analisis regresi cox dipakai untuk menganalisis faktor-faktor dominan yang berhubungan dengan kebiasaan makan protein berlebih. Hasil: Di antara 528 pilot yang berusia 19-64 tahun, 194 (36.74%) pilot memiliki kebiasaan makan protein berlebih. Lama masa kerja dan indeks massa tubuh menjadi faktor risiko dominan yang berkaitan dengan kebiasaan makan protein berlebih pada pilot. Jika dibandingkan dengan pilot dengan lama masa kerja 1 – 9 tahun, pilot dengan masa kerja 10 – 40 tahun berisiko 35% lebih kecil memiliki kebiasaan makan protein berlebih (RRa = 0.65 ; 95% CI 0.49 – 0.87). Jika dibandingkan dengan pilot dengan indeks massa tubuh normal, pilot yang overweight berisiko 34% lebih  kecil  memiliki kebiasaan makan protein berlebih (RRa = 0.66 ; 95% CI 0.47 – 0.93). Kesimpulan: Masa kerja yang lebih panjang dan overweight merupakan faktor protektif terhadap risiko kebiasaan makan protein berlebih Kata kunci: kebiasaan makan protein, lama masa kerja, indeks massa tubuh, pilot sipil Indonesia       ABSTRACT Background: Excessive protein eating habits may cause kidney and liver disease and increase the risk of cardiovascular disease leading to incapacitation of the pilot. The purpose of this study was to identify sociodemographic and other factors on protein eating habits among civilian pilots in Indonesia. Methods: A cross-sectional study using secondary data from the survey of eating, drinking and physical exercise habits among civilian pilots in Indonesia 2016. Data collected were demographic characteristics, physical exercise habits, smoking habits, knowledge, body mass index and flight characteristics. Cox regression analysis was used to analyze the dominant factors associated with protein eating habits. Results: Among 528 pilots aged 19-64 years, 194 (36.74%) pilots had excessive protein eating habits . Long working period and body mass index were the dominant risk factors associated with protein eating habit in pilots. Compared to pilots with 1-9 years working period, pilots with 10-40 years working period had 35% lower risk of excessive protein eating habits (RRA = 0.65; 95% CI 0:49 - 0.87). Compared to pilots with normal body mass index, overweight pilots had 34% lower risk of excessive protein eating habits (RRA = 0.66; 95% CI 0:47 - 0.93). Conclusion: Long working period and overweight were protective factors from the risk of excessive protein eating habits Keywords: protein eating habits, total working periode, body mass index, civilian pilots Indonesia
      PubDate: 2017-07-17
      Issue No: Vol. 8 (2017)
       
  • Effect of fever duration before hospitalization and hemoconcentration to
           length of stay of dengue patients

    • Authors: Christine Ernita Banggai
      Abstract: Abstrak Latar Belakang: Identifikasi dini kondisi klinis serta penanganan yang tepat terhadap pasien dengue merupakan hal penting untuk mencegah perkembangan penyakit menjadi lebih berat. Hal ini akan berdampak positif bagi perawatan pasien yang menjadi lebih singkat dan dengan sendirinya biaya semakin rendah. Tujuan kajian adalah untuk mengetahui pengaruh durasi demam sebelum pasien dirawat di rumah sakit dan hemokonsentrasi terhadap lama waktu perawatan pasien dengue. Metode: Studi potong lintang secara random sampling yang dilakukan terhadap catatan medis pasien dengue yang dirawat inap di RSPI Prof. Dr. Sulianti Saroso periode Januari 2014 s/d Desember 2015. Analisis dilakukan secara multivariat dengan regresi Cox. Hasil: Pada 153 sampel catatan medis pasien dengue yang dianalisis, hasil menunjukkan terdapat 21,6% pasien yang dirawat lebih dari 6 hari. Durasi demam sebelum pasien dirawat di rumah sakit dan hemokonsentrasi merupakan dua faktor  yang berpengaruh signifikan terhadap lama perawatan pasien lebih dari 6 hari. Subyek dengan durasi demam 3 hari [aRR=0.38; P=0.024]  dan lebih dari 3 hari sebelum dirawat di rumah sakit [aRR=0.27; P=0.000] berpengaruh signifikan terhadap lama perawatan lebih dari 6 hari. Subyek dengan hemokonsentrasi menunjukkan risiko 1,8 kali lebih besar untuk lama perawatan lebih dari 6  hari [aRR=1.84; P=0.042]. Kesimpulan: Durasi demam 3 hari dan lebih dari 3 hari sebelum dirawat di rumah sakit serta adanya hemokonsentrasi pada pasien dengue di RSPI Prof. Dr. Sulianti Saroso, berperan signifikan terhadap lama waktu perawatan lebih dari 6  hari. Kata kunci: Dengue, durasi demam, hemokonsentrasi, lama perawatan  Abstract Backgrounds: Early identification of clinical conditions and proper treatment to dengue patients is essential to prevent the development of more severe condition. This can lead to shorter length of stay and lower cost of patient care in hospitals. The objective of this study was to determine the effect of fever duration before hospitalization and hemoconcentration to length of stay of dengue patients.   Methods: A cross-sectional study conducted by random sampling on the medical records of dengue patients hospitalized in RSPI Prof. Dr. Sulianti Saroso period January 2014-December 2015. Multivariate analyzes were performed with Cox regression.   Results: There were 153 samples of dengue patient’s medical record for analysis, 21.6% of them were hospitalized over 6 days. Duration of fever before hospitalization and hemoconcentration were significant to length of stay more than 6 days. Subjects with duration of fever for 3 days [aRR = 0.38; P = 0.024] and more than 3 days before hospitalization [aRR = 0.27; P = 0.000] were significant to length of stay more than 6 days. Subjects with hemoconcentration had higher risk  by 1,8 times to length of stay more than 6 days  [aRR = 1.84; P = 0.042]. Conclusion: Fever duration for 3 days, for more than 3 days before hospitalization, and hemoconcentration in dengue patients were significantly related to length of stay more than 6 days.   Keywords: Dengue, fever duration, hemoconcentration, length of stay      
      PubDate: 2017-07-17
      Issue No: Vol. 8 (2017)
       
  • In Vitro Study of Eight Indonesian Natural Extracts as Antiviral Against
           Dengue Virus

    • Authors: Leli Saptawati, Ratih Puspita Febrinasari, Ratih Dewi Yudhani, Hudi Yono, Agya Ghilman Faza, Sarah Luthfiani, Hutami Sri Ummiyati, T Mirawati Sudiro, Beti Ernawati Dewi
      Abstract: Background: Dengue hemorrhagic fever (DHF) caused by a dengue viruses is still a major problem in tropical countries, including Indonesia. World Health Organization data showed that over 40% of world population are at risk of DHF.1In 2014 there were 71.668 of DHF cases in 34 provinces with 641 death.2 In Central Java in 2013, the incidence rate and fatality rate of DHF was 45.52 in 100.000 populations and 1.21% respectively.3 Until nowadays, there is no vaccine or effective therapy is available as yet.4 Thus research on discovering specific antiviral against dengue is needed. Indonesia is rich in indigenous herbal plants, which may has potential antiviral activity, such as Psidium guajava (Jambu biji), Euphorbia hirta (Patikn kerbau), Piper bettle L (Sirih), Carica papaya (Pepaya), Curcuma longa L(Kunyit/turmeric), Phyllanthus niruri L (meniran), Andrographis paniculata (Sambiloto), Cymbopogon citrates (Serai). Previous studies show that these plants have antiviral and antibacterial properties.5However, there is only limited study of these plants against dengue virus . Objective: This study aimed to know whether these plants have potential activity against dengue virus in vitro. Method: Leave extracts of eight indigenous herbal plants as mention before were originated from Solo, Central Java, the crude extracts were tested in vitro against dengue virus serotype 2 (DENV-2) strain NGC using Huh7it-1 cell line. Those crude extracts were screened for antiviral activity using doses of 20mg/ml. Candidates that showed inhibition activity were further tested in various doses to determine IC50 and CC50. Result: From eight leave extracts tested, one of them i.e Carica papaya (pepaya) inhibited virus replication up to 89,5%. Dose dependent assay with C.papaya resulted in IC50, CC50 and selectivity index 6,57 μg/mL, 244,76 μg/mL and 37, 25 μg/mL respectively. Conclusion: C.papaya has potential antiviral activity against dengue virus in vitro. Further study is needed to confirm antiviral activity in vivo. Key word : Dengue virus, natural extract, antiviral activity,
      PubDate: 2017-07-17
      Issue No: Vol. 8 (2017)
       
 
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
 
Home (Search)
Subjects A-Z
Publishers A-Z
Customise
APIs
Your IP address: 54.167.231.97
 
About JournalTOCs
API
Help
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-2016