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Publisher: Universitat de Barcelona   (Total: 32 journals)   [Sort by number of followers]

Showing 1 - 32 of 32 Journals sorted alphabetically
452ºF. Revista de Teoría de la literatura y Literatura Comparada     Open Access   (Followers: 3)
Abriu : Textuality Studies on Brazil, Galicia and Portugal     Open Access   (Followers: 1)
Acta Artis : Estudis d'Art Modern     Open Access   (Followers: 3)
Anuari de Filologia. Antiqua et Mediaeualia     Open Access   (Followers: 4)
Anuari de Filologia. Estudis de Lingüística     Open Access   (Followers: 3)
Anuari de Filologia. Literatures Contemporànies     Open Access   (Followers: 1)
Anuari de Filologia. Llengües i Literatures Modernes     Open Access  
Anuari del Conflicte Social     Open Access  
Anuario de Psicología / The UB J. of Psychology     Open Access   (Followers: 1, SJR: 0.17, CiteScore: 0)
BiD : textos universitaris de biblioteconomia i documentació     Open Access   (Followers: 6)
Biologia on-line : Revista de divulgació de la Facultat de Biologia     Open Access  
Boletín Americanista     Open Access   (SJR: 0.1, CiteScore: 0)
Bulletin du Groupement Intl. pour la Recherche Scientifique en Stomatologie et Odontologie     Open Access   (SJR: 0.441, CiteScore: 1)
Cercles. Revista d'Història Cultural     Open Access  
Clivatge. Estudis i testimonis sobre el conflicte i el canvi socials     Open Access  
Crítica Penal y Poder     Open Access  
Digital Education Review     Open Access   (Followers: 7, SJR: 0.222, CiteScore: 1)
FILMHISTORIA Online     Open Access   (Followers: 2)
Índice Histórico Español     Open Access  
J. of Evolutionary Studies in Business     Open Access   (Followers: 1)
Lectora : Revista de Dones i Textualitat     Open Access  
Llengua, societat i comunicació     Open Access  
Musas : Revista de Investigación en Mujer, Salud y Sociedad     Open Access  
Oxímora : Revista Internacional de Ética y Política     Open Access  
Phonica     Open Access  
Revista d'Innovació Docent Universitària     Open Access  
Revista d'Innovació i Recerca en Educació     Open Access   (Followers: 3)
Revista de Educación y Derecho     Open Access  
Revista de Estudios Globales y Arte Contemporáneo     Open Access   (Followers: 1)
RIDAS. Revista Iberoamericana de Aprendizaje Servicio     Open Access  
Segle XX : revista catalana d'història     Open Access  
SVMMA. Revista de Cultures Medievals     Open Access   (Followers: 1, SJR: 0.101, CiteScore: 0)
Journal Cover
Bulletin du Groupement International pour la Recherche Scientifique en Stomatologie et Odontologie
Journal Prestige (SJR): 0.441
Citation Impact (citeScore): 1
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0250-4693 - ISSN (Online) 1647-1377
Published by Universitat de Barcelona Homepage  [32 journals]
  • Epigenetic modifications in salivary glands from patients with
           Sjögren's syndrome affect cytokeratin 19 expression

    • Authors: O.D. Konsta, A. Charras, C. Le Dantec, E. Kapsogeorgeou, A. Bordron, W.H. Brooks, A.G. Tzioufas, J.O. Pers, Y. Renaudineau
      First page: 01
      Abstract: Sjögren’s syndrome (SS) is a chronic autoimmune epithelitis, and several lines of experiments indicate that multifactorial factors contribute to salivary gland epithelial cells (SGEC) dysfunctions including a combination of environmental factors, lymphocytic infiltrations, genetic predispositions as well as epigenetic defects. Such statement is reinforced by the observation that global DNA methylation (5MeCyt) is altered in minor salivary glands from pSS patients and that such defect is associated cytokeratin 19 (KRT19) overexpression. An epigenetic deregulation of the KRT19 gene was further tested by treating the human salivary gland (HSG) cell line with the DNA demethylating agent 5-azacytidin, and with the histone acetylase inhibitor trichostatin A. Blocking DNA methylation, but not histone acetylation, with 5-azacytidin was associated with KRT19 overexpression at both transcriptional and protein level. Next, analysis of the CpG genome-wide methylome array in the KTR19 locus from long term cultured SGEC obtained from 8 pSS patients revealed a more reduced DNA methylation level in those patients with defective global DNA methylation. Altogether, our data, therefore, suggest that alteration of DNA methylation in SGEC may contribute to pSS pathophysiology in part by controlling the expression of KRT19.
      PubDate: 2016-06-28
      Issue No: Vol. 53 (2016)
       
  • Intraplaque hemorrhage, a potential consequence of periodontal bacteria
           gathering in human carotid atherothrombosis

    • Authors: Adrian Brun, Hélène Rangé, Bastien Prouvost, Olivier Meilhac, Mikael Mazighi, Pierre Amarenco, Guy Lesèche, Philippe Bouchard, Jean-Baptiste Michel
      First page: 11
      Abstract: Periodontal diseases are multifactorial inflammatory diseases, caused by a bacterial biofilm involving both innate and adaptative immunity, characterized by the destruction of tooth-supporting tissues. In the context of periodontitis, the spread of weak pathogenic bacteria into the bloodstream has been described. These bacteria will preferentially localize to existing clot within the circulation. Atherothrombosis of the carotid arteries is a local pathology and a common cause of cerebral infarction. Intraplaque hemorrhages render the lesion more prone to clinical complications such as stroke. The main objective of this study is to explore the biological relationship between carotid intraplaque hemorrhage and periodontal diseases. This study included consecutive patients with symptomatic or asymptomatic carotid stenosis, admitted for endarterectomy surgical procedure (n=41). In conditioned media of the carotid samples collected, markers of neutrophil activation (myeloperoxidase or MPO, DNA-MPO complexes) and hemoglobin were quantified. To investigate the presence of DNA from periodontal bacteria in atherosclerotic plaque, PCR analysis using specific primers was performed. Our preliminary results indicate an association between neutrophil activation and intraplaque hemorrhages, reflected by the release of MPO (p<0,01) and MPO-DNA complexes (p<0,05). Presence of DNA from periodontitis-associated bacteria was found in 32/41 (78%) atheromatous plaque samples. More specifically, DNA from Pg, Tf, Pi, Aa was found in 46%, 24%, 34% and 68% of the samples, respectively. Hemoglobin levels were higher in conditioned media in carotid samples where the bacteria were found, but this was not statistically significant. Our data confirm the relationship between intraplaque hemorrhage and neutrophil activation. In addition, the presence of periodontal bacteria DNA in carotid atheromatous plaque, may contribute to this activation. Further analysis is needed to fully explore the raw data and specimens.
      PubDate: 2016-06-28
      Issue No: Vol. 53 (2016)
       
  • Expression of phosphate transporters in optimized cell culture models for
           dental cells biomineralization

    • Authors: Laure Merametdjian, Amandine David, Nina Bon, Greig Couasnay, Jérôme Guicheux, Céline Gaucher, Sarah Beck-Cormier, Laurent Beck
      First page: 16
      Abstract: Phosphate is a key component of dental mineral composition. The physiological role of membrane proteins of dental cells is suspected to be crucial for mineralization mechanisms. Contrary to published data related to calcium, data on regulation of phosphate flux through membrane of mineralizing cells are scarce. To address this lack of data, we studied the expression of six membranous phosphate transporters in two dental cell lines: a rat odontoblastic cell line (M2H4) and a mouse ameloblastic cell line (ALC) for which we optimized the mineralizing culture conditions.
      PubDate: 2016-06-28
      Issue No: Vol. 53 (2016)
       
  • Impact of three endocrine disruptors, Bisphenol A, Genistein and
           Vinclozolin on female rat enamel

    • Authors: K. Jedeon, A. Berdal, A. Babajko
      First page: 28
      Abstract: Concerns about the potential adverse effects
      of endocrine disruptors (EDs) have been increasing
      over the last three decades. Bisphenol
      A (BPA), genistein (G) and vinclozolin (V) are
      three widely used EDs sharing similar effects.
      Since populations are exposed to many diverse
      EDs simultaneously, we demonstrated
      recently their impact alone or combined on
      male rat tooth enamel. The purpose of this
      study was therefore to assess their effects on
      female rat tooth enamel in order to understand
      why they are differentially sensitive. Rats
      were exposed daily in utero and after birth to
      low doses of EDs during the critical fetal and
      suckling periods when amelogenesis takes
      place. Enamel of rats exposed to EDs presented
      opaque areas of hypomineralization. The
      proportion of affected rats was the highest
      in the groups of rats treated with BPA alone
      and higher in males than in females (in all the
      groups). Comparison of enamel key gene expression
      levels showed modulations of Klk4
      and Enamelin in males but no significant variations
      in females. These findings show that
      female rats are less affected than males by
      the three EDs chosen in this study and suggest
      that enamel hypomineralization may differ
      between males and females
      PubDate: 2016-06-28
      Issue No: Vol. 53 (2016)
       
  • Mineral density of hypomineralised and sound enamel

    • Authors: Elsa Garot, Patrick Rouas, Emmanuel d'Incau, Nicolas Lenoir, David Manton, Christine Couture-Veschambre
      First page: 33
      Abstract: Molar Incisor Hypomineralisation (MIH) is a structural anomaly that affects the quality of tooth enamel and has important consequences for oral health. The developmentally hypomineralised enamel has normal thickness and can range in colour from white to yellow or brown. The purpose of the present study is to compare the mineral density of hypomineralised and normal enamel. The sample included eight MIH teeth from seven patients. MIH teeth were scanned using high resolution microtomography. Non-parametric statistical tests (Wilcoxon test for paired samples) were carried out. Hypomineralised enamel has decreased mineral density (mean 19%; p < 0.0001) compared to normal enamel. This weak enamel has implications in clinical management of MIH lesions.
      PubDate: 2016-06-28
      Issue No: Vol. 53 (2016)
       
  • A standardized procedure to obtain mesenchymal stem/stromal cells from
           minimally manipulated dental pulp and Wharton’s jelly samples

    • Authors: M. Ducret, H. Fabre, O. Degoult, G. Atzeni, C. McGuckin, N. Forraz, F. Mallein-Gerrin, E. Perrier-Groult, J.C. Fargues
      First page: 37
      Abstract: Transplantation of mesenchymal stem/stromal
      cells (MSCs) has emerged as an effective
      method to treat diseased or damaged
      organs and tissues, and hundreds of clinical
      trials using MSCs are currently under way to
      demonstrate the validity of such a therapeutic
      approach. However, most MSCs used for clinical
      trials are prepared in research laboratories
      with insufficient manufacturing quality control.
      In particular, laboratories lack standardized
      procedures for in vitro isolation of MSCs from
      tissue samples, resulting in heterogeneous
      populations of cells and variable experimental
      and clinical results.
      MSCs are now referred to as Human Cellular
      Tissue-based Products or Advanced Therapy
      Medicinal Products, and guidelines from
      the American Code of Federal Regulation of
      the Food and Drug Administration (21 CFR
      Part 1271) and from the European Medicines
      Agency (European Directive 1394/2007) define
      requirements for appropriate production of
      these cells. These guidelines, commonly called
      “Good Manufacturing Practices” (GMP),
      include recommendations about laboratory
      cell culture procedures to ensure optimal reproducibility,
      efficacy and safety of the final
      medicinal product. In particular, the Food and
      Drug Administration divides ex vivo cultured
      cells into “minimally” and “more than minimally”
      manipulated samples, in function of the
      use or not of procedures “that might alter the
      biological features of the cells”. Today, minimal
      manipulation conditions have not been
      defined for the collection and isolation of
      MSCs (Torre et al. 2015)(Ducret et al. 2015).
      Most if not all culture protocols that have been
      reported so far are unsatisfactory, because
      of the use of xeno- or allogeneic cell culture
      media, enzymatic treatment and long-term
      cell amplification that are known to alter the
      quality of MSCs.
      The aim of this study was to describe a standardized
      procedure for recovering MSCs with
      minimal handling from two promising sources,
      the dental pulp (DP) and the Wharton’s jelly
      (WJ) of the umbilical cord. The quality and homogeneity
      of the expanded cell populations
      were assessed by using flow cytometry with
      criteria that go beyond the International Society
      of Cellular Therapy (ISCT) guidelines for
      MSC characterization.
      PubDate: 2016-06-28
      Issue No: Vol. 53 (2016)
       
 
 
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