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Publisher: Elmer Press   (Total: 11 journals)   [Sort by number of followers]

Showing 1 - 11 of 11 Journals sorted alphabetically
Cardiology Research     Open Access   (Followers: 15, SJR: 0.112, CiteScore: 0)
Gastroenterology Research     Open Access   (Followers: 7)
Intl. J. of Clinical Pediatrics     Open Access   (Followers: 5)
J. of Clinical Medicine Research     Open Access   (Followers: 4)
J. of Current Surgery     Open Access   (Followers: 2)
J. of Endocrinology and Metabolism     Open Access   (Followers: 5)
J. of Hematology     Open Access   (Followers: 4)
J. of Medical Cases     Open Access   (Followers: 6)
J. of Neurology Research     Open Access   (Followers: 6)
World J. of Nephrology and Urology     Open Access   (Followers: 15)
World J. of Oncology     Open Access   (Followers: 1, SJR: 0.122, CiteScore: 0)
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Journal of Neurology Research
Number of Followers: 6  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1923-2845 - ISSN (Online) 1923-2853
Published by Elmer Press Homepage  [11 journals]
  • Progress in the Treatment of Acute Ischemic Stroke, Current Challenges and
           the Establishment of Clinical Decision-Making System

    • Authors: Yi Bao, Xinyu Du, Miao Zhang, Ran An, Jing Xiao, Xiaodong Liu, Guangjian Liu
      Abstract: Ischemic stroke often occurs in middle-aged and elderly people, leading to brain tissue ischemia, hypoxia and necrosis. The clinical manifestations are a series of neurological deficits, such as aphasia, hemiplegia and disturbance of consciousness, with high morbidity, mortality, disability rate, recurrence rate and multiple complications. This article aims to review current treatment advances, analyze current challenges and propose coping strategies. The literature on stroke treatment and the latest technological progress were reviewed. Combined with clinical and epidemiological to analyze the current challenges, the coping strategies were proposed before, during and after thrombolysis. Early intravenous thrombolysis and bridging treatment can restore blood perfusion in time and save the ischemic penumbra of brain tissue. However, the current proportion of patients receiving thrombolytic therapy is very low. The main challenges are as follows: easy to miss the time window, door-to-needle time is too long and there is a lack of understanding of the safety and efficacy of thrombolysis, especially the hemorrhagic transformation. A clinical decision-making system is established for stroke rescue by improving the popularization rate of stroke thrombolytic therapy, optimizing the green channel process of stroke and improving the executive ability of clinicians, to shorten the rescue time. Advanced imaging techniques are used to identify potential patients for thrombolysis. Acute intravascular bridge therapy is used to improve the efficacy of thrombolysis. Screening before thrombolysis, timely thrombolytic therapy, re-examination after thrombolysis and active response to hemorrhagic transformation can effectively improve the safety and acceptability of treatment.




      J Neurol Res. 2019;9(4-5):51-59
      doi: https://doi.org/10.14740/jnr541
      PubDate: 2019-10-10
      Issue No: Vol. 9 (2019)
       
  • Update on an Asian Indian Family With Apparent Autosomal Recessive
           Charcot-Marie-Tooth Disease Caused by a Mutation in the HSPB1 Gene

    • Authors: Leema Reddy Peddareddygari, Kinsi Oberoi, Raji P. Grewal
      Abstract: Background: We described an Asian Indian family with a genetic neuropathy previously in the Journal of Neurology Research, 2012. In that publication, we speculated that a deletion mutation in the PRX gene may have contributed to the development of the neuropathy. In this family, there is significant phenotypic variability which created difficulties establishing the mode of transmission which appeared to be autosomal recessive. We now present our updated analysis with additional clinical and genetic data.Methods: We obtained clinical and phenotype data on additional members of this family. We performed whole exome sequencing on the index patient and targeted genotyping of other members of the family.Results: Our updated analysis establishes the pattern of inheritance of this neuropathy as autosomal dominant and caused by a mutation in the HSPB1 gene, R140G. The R140G mutation has been previously reported in a number of unrelated families originating from Gujarat, the same Indian state as the subjects of this study.Conclusions: The collective genetic analysis of this mutation in the Gujarati families suggests the presence of a founder effect of the R140G mutation in this population. Our investigation of this family demonstrates the capacity of next generation sequencing in facilitating the ability to make a specific genetic diagnosis.




      J Neurol Res. 2019;9(4-5):60-64
      doi: https://doi.org/10.14740/jnr547
      PubDate: 2019-10-10
      Issue No: Vol. 9 (2019)
       
  • The Association of Optical Coherence Tomography Results With Neuroimaging
           Signs and Some Clinical Parameters in Idiopathic Intracranial Hypertension
           

    • Authors: Halil Onder, Erol Erkan
      Abstract: Background: Recently, optical coherence tomography (OCT) has enhanced our understanding of visual disturbances in idiopathic intracranial hypertension (IIH). Its importance in the evaluation process of IIH has been established; however, there are many unknown aspects regarding the relationship of OCT measurements with several clinical features of IIH. Herein, we aimed to investigate the associations of OCT measurements with neuroimaging findings and some clinical parameters in our cohort with IIH.Methods: Patients over 18 years of age presenting to the neurology and neuro-ophthalmology outpatient clinics, between 2017 and 2019, who were diagnosed with IIH were included in the study. Cranial magnetic resonance imaging (MRI) recordings were retrospectively evaluated for the presence of neuroimaging signs of intracranial hypertension. Peripapillary retinal nerve fiber layer (RNFL) measurements and other clinical parameters were retrospectively evaluated from the hospital recoding system. SPSS Statistics (version 20) were used for statistical analyses.Results: We have included 18 patients of IIH with a mean age of 38.6 years (range: 19 - 69 years) and female/male ratio was 17:1. Mean body mass index (BMI) of the patients was 30.5 ± 5.7 and mean lumbar puncture (LP) opening pressure was 313.8 ± 66.6 mm H2O. Correlation analyses between LP opening pressure and average RNFL thickness of the right eye revealed a significant positive correlation. The results of the other correlation analyses were unremarkable.Conclusions: We have found a significant correlation between LP opening pressure and RNFL thickness of the right eye. No association between RNFL measurement and MRI signs of intracranial hypertension was found. Investigating the possible associations between RNFL measurements and the clinical and neuroimaging signs in future studies may provide crucial contributions regarding the unknown aspects of IIH pathophysiology.




      J Neurol Res. 2019;9(4-5):65-71
      doi: https://doi.org/10.14740/jnr550
      PubDate: 2019-10-10
      Issue No: Vol. 9 (2019)
       
  • Chronic Inflammatory Demyelinating Polyradiculoneuropathy Association With
           

    • Authors: Diana Carolina Franco, Neelam Neupane, Maria Riaz, Sanaz Mohammadzadeh, Issac Sachmechi
      Abstract: A 57-year-old woman with history of prediabetes and dyslipidemia treated with PCSK9 inhibitors due to statin intolerance presented to the clinic with complaints of bilateral thigh pain, weakness and numbness. During the physical exam, the patient exhibited stocking loss of vibratory and cold temperature sensation in both legs, absent ankle reflexes and tandem imbalance with normal cranial nerve functions. After all the clinical studies, the patient was diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) as an exclusion diagnosis. A link with medications (Praluent) was determined to be the most possible offending agent. With this case, we present a rare case of CIDP in the setting of low level of low-density lipoprotein cholesterol (LDL-C) due to PCSK9 inhibitors. This case opens the door to a new and unrecognized adverse effect of this type of medication.




      J Neurol Res. 2019;9(4-5):72-74
      doi: https://doi.org/10.14740/jnr552
      PubDate: 2019-10-10
      Issue No: Vol. 9 (2019)
       
  • Ischemic Stroke Secondary to Left Ventricular Noncompaction

    • Authors: Hussam A. Yacoub, Keithan Sivakumar, Mohammed El-Hunjul, Chun Chu, Dev Mehta
      Abstract: Left ventricular noncompaction (LVNC) is a rare cause of cardiomyopathy that can lead to systemic embolism and ischemic stroke. LVNC results from the arrest of ventricular myocardium compaction during embryogenesis. Multiple other cardiac complications coexist with this cardiomyopathy, and one of the potential consequences is cardioembolic events causing ischemic stroke. This condition can be underdiagnosed or misdiagnosed as hypertrophic or dilated cardiomyopathy. We report a patient who presented with recurrent embolic ischemic stroke secondary to LVNC that was overlooked on initial transthoracic echocardiographic studies. After an unremarkable laboratory workup, transesophageal echocardiogram (TEE) revealed noncompaction of the myocardium within the apex of the left ventricle, confirmed by cardiac magnetic resonance imaging (MRI). The patient was anticoagulated with warfarin and discharged to a rehabilitation facility. Increased understanding and awareness of the diagnosis, clinical manifestations, and management of LVNC are advised, particularly in patients with recurrent embolic stroke of undetermined source. Screening of all first-degree relatives with this familial condition is recommended as well, as appropriate treatment can prevent cardiac complications and sudden death.




      J Neurol Res. 2019;9(4-5):75-80
      doi: https://doi.org/10.14740/jnr553
      PubDate: 2019-10-10
      Issue No: Vol. 9 (2019)
       
  • Characteristic Analysis and Literature Review of Hereditary
           Spinocerebellar Ataxia With Lumbar Spondylolisthesis and Valvular Prolapse
           

    • Authors: Yi Bao, Wanjuan Tang, Siqin Zhou, Ying Wang, Jing Xiao, Lei Gao, Ran An, Guangjian Liu
      Abstract:  Spinocerebellar ataxia (SCA) is an autosomal dominant disease with high genetic heterogeneity, which cannot be cured until now. According to clinical manifestations or genetic pathology classification, SCA types 1 to 47 have been characterized so far, and the pathogenic genes of 28 SCA types have been identified. The clinical manifestations of the disease are diverse and easy to be misdiagnosed. This study aims to describe the family characteristics, specific clinical manifestations and genotyping of SCA patients. Magnetic resonance imaging (MRI) was used to check the atrophy of the brain and spinal cord. The lumbar spondylolisthesis was examined by computed tomography (CT). The possible influencing factors were analyzed by questioning each member of the patient’s family, especially the persons with the disease, to draw the genetic genealogy. Relevant literatures were searched to compare differences in genotypes between the patient and similar clinical manifestations. Craniocerebral MRI showed that cerebellar sulcus widened and deepened, vermis atrophy; enlargement of the cistern around the brainstem; cerebral cortex atrophy, furrow, fissure widen. Lumbar CT showed L3 spondylolisthesis slightly to the right. Genetic genealogy showed that the children of the patients still had the disease, and the children of the patients without the disease were all normal, which is consistent with the autosomal dominant genetic law. Compared with the literature, the patient had the same clinical manifestations as Machado’s disease: convex eyes, dysarthria, terminal muscles atrophy, ataxia gait, weakened tendon reflex, and arched foot. The same clinical manifestations of SCA40 included ataxia, wide-based gait, poor range discrimination and rotation movement disorder, but there were also many discrepancies. The patient’s lumbar spondylolisthesis and valvular prolapse were not present in any of the previous types. In conclusion, craniocerebral MRI and gene sequencing can help distinguish and diagnosis the subtypes of SCA; whether this patient is a new subtype with lumbar spondylolisthesis and heart valve prolapse needs further study; this genealogy supports that through eugenics dominant genetic diseases being passed on to the offspring can be avoided.




      J Neurol Res. 2019;9(4-5):81-88
      doi: https://doi.org/10.14740/jnr544 
      PubDate: 2019-10-10
      Issue No: Vol. 9 (2019)
       
  • A Dramatic Improvement by Ventriculoperitoneal Shunt Surgery in a Patient
           With Secondary Normal Pressure Hydrocephalus

    • Authors: Halil Onder, Umut D. Akturk
      Abstract: N/A




      J Neurol Res. 2019;9(4-5):89-91
      doi: https://doi.org/10.14740/jnr545

      PubDate: 2019-10-10
      Issue No: Vol. 9 (2019)
       
 
 
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