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Publisher: Science and Education Publishing   (Total: 72 journals)   [Sort by number of followers]

Showing 1 - 72 of 72 Journals sorted alphabetically
American J. of Applied Mathematics and Statistics     Open Access   (Followers: 7)
American J. of Applied Psychology     Open Access   (Followers: 27)
American J. of Biomedical Research     Open Access   (Followers: 1)
American J. of Cancer Prevention     Open Access   (Followers: 5)
American J. of Civil Engineering and Architecture     Open Access   (Followers: 27)
American J. of Clinical Medicine Research     Open Access   (Followers: 5)
American J. of Educational Research     Open Access   (Followers: 52)
American J. of Electrical and Electronic Engineering     Open Access   (Followers: 19)
American J. of Energy Research     Open Access   (Followers: 9)
American J. of Environmental Protection     Open Access   (Followers: 6)
American J. of Epidemiology and Infectious Disease     Open Access   (Followers: 9)
American J. of Food and Nutrition     Open Access   (Followers: 23)
American J. of Food Science and Technology     Open Access   (Followers: 4)
American J. of Infectious Diseases and Microbiology     Open Access   (Followers: 17)
American J. of Information Systems     Open Access   (Followers: 5)
American J. of Materials Engineering and Technology     Open Access   (Followers: 2)
American J. of Materials Science and Engineering     Open Access   (Followers: 3)
American J. of Mathematical Analysis     Open Access  
American J. of Mechanical Engineering     Open Access   (Followers: 20)
American J. of Medical and Biological Research     Open Access   (Followers: 5)
American J. of Medical Case Reports     Open Access  
American J. of Medical Sciences and Medicine     Open Access  
American J. of Medicine Studies     Open Access  
American J. of Microbiological Research     Open Access   (Followers: 2)
American J. of Modeling and Optimization     Open Access   (Followers: 1)
American J. of Nanomaterials     Open Access   (Followers: 4)
American J. of Numerical Analysis     Open Access   (Followers: 3)
American J. of Pharmacological Sciences     Open Access   (Followers: 2)
American J. of Public Health Research     Open Access   (Followers: 23)
American J. of Rural Development     Open Access   (Followers: 3)
American J. of Sensor Technology     Open Access   (Followers: 1)
American J. of Sports Science and Medicine     Open Access   (Followers: 21)
American J. of Water Resources     Open Access   (Followers: 5)
American J. of Zoological Research     Open Access  
Applied Ecology and Environmental Sciences     Open Access   (Followers: 15)
Automatic Control and Information Sciences     Open Access  
Biomedical Science and Engineering     Open Access   (Followers: 4)
Chemical Engineering and Science     Open Access   (Followers: 14)
Intl. J. of Celiac Disease     Open Access   (Followers: 2)
Intl. J. of Dental Sciences and Research     Open Access   (Followers: 1)
Intl. J. of Econometrics and Financial Management     Open Access   (Followers: 3)
Intl. J. of Physics     Open Access   (Followers: 11)
Intl. Transaction of Electrical and Computer Engineers System     Open Access   (Followers: 2)
J. of Automation and Control     Open Access   (Followers: 5)
J. of Biomedical Engineering and Technology     Open Access   (Followers: 1)
J. of Business and Management Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Treatment     Open Access   (Followers: 3)
J. of Computer Networks     Open Access   (Followers: 4)
J. of Computer Sciences and Applications     Open Access  
J. of Environment Pollution and Human Health     Open Access   (Followers: 3)
J. of Finance and Accounting     Open Access   (Followers: 3)
J. of Finance and Economics     Open Access   (Followers: 9)
J. of Food and Nutrition Research     Open Access   (Followers: 5, SJR: 0.334, h-index: 13)
J. of Food Security     Open Access  
J. of Geosciences and Geomatics     Open Access  
J. of Materials Physics and Chemistry     Open Access   (Followers: 1)
J. of Mathematical Sciences and Applications     Open Access   (Followers: 1)
J. of Optoelectronics Engineering     Open Access   (Followers: 2)
J. of Polymer and Biopolymer Physics Chemistry     Open Access   (Followers: 4)
Materials Science and Metallurgy Engineering     Open Access   (Followers: 4)
Nanoscience and Nanotechnology Research     Open Access   (Followers: 19)
Physics and Materials Chemistry     Open Access   (Followers: 1)
Research in Plant Sciences     Open Access  
Research in Psychology and Behavioral Sciences     Open Access   (Followers: 2)
Sustainable Energy     Open Access   (Followers: 1)
Turkish J. of Analysis and Number Theory     Open Access   (Followers: 1)
Wireless and Mobile Technologies     Open Access   (Followers: 5)
World J. of Agricultural Research     Open Access  
World J. of Analytical Chemistry     Open Access   (Followers: 1)
World J. of Chemical Education     Open Access   (Followers: 1)
World J. of Environmental Engineering     Open Access   (Followers: 2)
World J. of Organic Chemistry     Open Access   (Followers: 3)
Journal Cover American Journal of Medical and Biological Research
  [5 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2328-4080 - ISSN (Online) 2328-4099
   Published by Science and Education Publishing Homepage  [72 journals]
  • Serotype Independent Vaccine Design against Streptococcus pneumoniae Based
           on B-cell Epitopes of Autolysin, Zinc Binding Lipoprotein and Plasmid
           Stabilization Protein

    • Authors: Shirin Tarahomjoo
      Pages: 84 - 89
      Abstract: Pneumococcal conjugate vaccines (PCVs) were constructed through chemical conjugation of pneumococcal capsules to immunogenic carrier proteins. The PCVs implementation in developing countries was prevented by their high manufacturing costs. This issue can be overcome by development of protein based vaccines against pneumococci. Antibody responses are necessary for protection against S. pneumoniae. Autolysin, zinc binding lipoprotein (ZBL), and plasmid stabilization protein (PSP) were already identified as pneumococcal surface proteins able to elicit protection against S. pneumoniae serotype 19F and their most probable immunoprotective B-cell epitope regions (MIBRs) were determined. MIBRs were fully conserved in the most common pneumococcal serotypes causing invasive pneumococcal disease in children. Whole antigens are not as potent as epitope based vaccines and every epitope in a multi epitope based vaccine can individually induce a protective immune response against the pathogen. Thus better immunoprotection can be achieved by multi epitope based vaccines. In the present study, therefore, we aim to design a chimerical vaccine against pneumococci based on the identified MIBRs using immunoinformatic tools. These regions were joined together using the (EAAAK) 4 linker. The MIBRs orders affected the immunoprotective ability of the fusion protein as estimated by VaxiJen tool. The fusion protein consisting of MIBRs of autolysin, PSP and ZBL respectively (APZ) showed the highest probability for eliciting immunoprotection and was used for further study. The codon optimization was done for APZ using OPTIMIZER. Analysis of the mRNA secondary structure using Mfold tool revealed no stable hairpin at the 5' end and thus the antigen can be expressed appropriately. The 3D model of the antigen resulted from I-TASSER indicated the presence of alpha helix, turn, and coil as the protein structural elements. Analyzing physicochemical properties of the chimerical antigen using ProtParam showed that the fusion protein was stable and its half life in Escherichia coli was more than 10 h. Considering the GRAVY score, the chimerical antigen possessed a hydrophilic nature and it can be expressed in the soluble form in E. coli at 92.2% probability. These results demonstrated that the chimerical antigen composed of conserved MIBRs is a suitable vaccine candidate, which can elicit protection against common pneumococcal serotypes.
      PubDate: 2016-11-15
      Issue No: Vol. 4, No. 5 (2016)
       
 
 
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