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Publisher: Science and Education Publishing   (Total: 72 journals)

American J. of Applied Mathematics and Statistics     Open Access   (Followers: 2)
American J. of Applied Psychology     Open Access   (Followers: 8)
American J. of Biomedical Research     Open Access   (Followers: 3)
American J. of Cancer Prevention     Open Access   (Followers: 5)
American J. of Civil Engineering and Architecture     Open Access   (Followers: 21)
American J. of Clinical Medicine Research     Open Access   (Followers: 6)
American J. of Educational Research     Open Access   (Followers: 32)
American J. of Electrical and Electronic Engineering     Open Access   (Followers: 11)
American J. of Energy Research     Open Access   (Followers: 7)
American J. of Environmental Protection     Open Access   (Followers: 5)
American J. of Epidemiology and Infectious Disease     Open Access   (Followers: 3)
American J. of Food and Nutrition     Open Access   (Followers: 4)
American J. of Food Science and Technology     Open Access   (Followers: 3)
American J. of Infectious Diseases and Microbiology     Open Access   (Followers: 14)
American J. of Information Systems     Open Access   (Followers: 2)
American J. of Materials Engineering and Technology     Open Access  
American J. of Materials Science and Engineering     Open Access   (Followers: 1)
American J. of Mathematical Analysis     Open Access  
American J. of Mechanical Engineering     Open Access   (Followers: 1)
American J. of Medical and Biological Research     Open Access   (Followers: 3)
American J. of Medical Case Reports     Open Access  
American J. of Medical Sciences and Medicine     Open Access  
American J. of Medicine Studies     Open Access  
American J. of Microbiological Research     Open Access  
American J. of Modeling and Optimization     Open Access   (Followers: 1)
American J. of Nanomaterials     Open Access  
American J. of Numerical Analysis     Open Access  
American J. of Pharmacological Sciences     Open Access   (Followers: 1)
American J. of Public Health Research     Open Access   (Followers: 14)
American J. of Rural Development     Open Access   (Followers: 1)
American J. of Sensor Technology     Open Access   (Followers: 1)
American J. of Sports Science and Medicine     Open Access   (Followers: 5)
American J. of Water Resources     Open Access   (Followers: 1)
American J. of Zoological Research     Open Access  
Applied Ecology and Environmental Sciences     Open Access   (Followers: 11)
Automatic Control and Information Sciences     Open Access  
Biomedical Science and Engineering     Open Access   (Followers: 1)
Chemical Engineering and Science     Open Access   (Followers: 3)
Intl. J. of Celiac Disease     Open Access   (Followers: 2)
Intl. J. of Dental Sciences and Research     Open Access  
Intl. J. of Econometrics and Financial Management     Open Access  
Intl. J. of Physics     Open Access  
Intl. Transaction of Electrical and Computer Engineers System     Open Access  
J. of Automation and Control     Open Access   (Followers: 1)
J. of Biomedical Engineering and Technology     Open Access  
J. of Business and Management Sciences     Open Access  
J. of Cancer Research and Treatment     Open Access   (Followers: 1)
J. of Computer Networks     Open Access  
J. of Computer Sciences and Applications     Open Access  
J. of Environment Pollution and Human Health     Open Access  
J. of Finance and Accounting     Open Access  
J. of Finance and Economics     Open Access   (Followers: 5)
J. of Food and Nutrition Research     Open Access   (SJR: 0.344, h-index: 11)
J. of Food Security     Open Access  
J. of Geosciences and Geomatics     Open Access  
J. of Materials Physics and Chemistry     Open Access  
J. of Mathematical Sciences and Applications     Open Access  
J. of Optoelectronics Engineering     Open Access  
J. of Polymer and Biopolymer Physics Chemistry     Open Access   (Followers: 1)
Materials Science and Metallurgy Engineering     Open Access   (Followers: 1)
Nanoscience and Nanotechnology Research     Open Access   (Followers: 1)
Physics and Materials Chemistry     Open Access  
Research in Plant Sciences     Open Access  
Research in Psychology and Behavioral Sciences     Open Access  
Sustainable Energy     Open Access  
Turkish J. of Analysis and Number Theory     Open Access   (Followers: 1)
Wireless and Mobile Technologies     Open Access  
World J. of Agricultural Research     Open Access   (Followers: 1)
World J. of Analytical Chemistry     Open Access  
World J. of Chemical Education     Open Access   (Followers: 1)
World J. of Environmental Engineering     Open Access  
World J. of Organic Chemistry     Open Access  
Journal Cover   American Journal of Pharmacological Sciences
  [3 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2327-6711 - ISSN (Online) 2327-672X
   Published by Science and Education Publishing Homepage  [72 journals]
  • The Use of Intravenous Immunoglobulins (IVIG) in Immunological Mediated
           Diseases and Possible Mechanisms of Actions

    • Authors: Angel Alberto Justiz Vaillant; Sehlule Vuma, Wayne Mohammed
      Pages: 33 - 37
      Abstract: Intravenous immunoglobulin (IVIG) is a product prepared from fractionation of pools of thousands of plasma donations collected at blood transfusion services. IVIG has been used in the treatment of neurological disorders, primary and secondary immunodeficiency, skin disorders, autoimmune disorders, immunologic abortion, and as anti-cancer and anti-inflammatory therapy. In this paper we listed a number of diseases for which the use of IVIG has been successful and the most mentioned mechanisms of actions of this immunotherapy. IVIG has different modes of actions involving interference with activation of complement components and the cytokine network; effects on regulatory T cells (Tregs) subset; expression of Fc receptors; modulation of idiotype network; and activation, proliferation and effector functions of B and T lymphocytes and of antigen-presenting cells such as dendritic cells and macrophages. We concluded that IVIG has proven to be efficacious in the treatment of immunodeficiency, autoimmunity, infections and inflammatory disorders over the last three decades. To date IVIG has been used to treat more than 80 diseases. Although some of the mechanisms of actions of IVIG are obscure in nature, the fact that many patients improved with it when all other options of treatment were exhausted, make the use of IVIG an important alternative. On the other hand, treatment with IVIG is expensive. We are hopeful that in near future new horizons will be open for the acquisition and use of a cheaper IVIG to treat weak immune system or as immunosuppressive drug in the treatment of autoimmune and inflammatory disorders.
      PubDate: 2015-04-08
      Issue No: Vol. 3, No. 2 (2015)
       
 
 
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