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Publisher: Science and Education Publishing   (Total: 72 journals)

American J. of Applied Mathematics and Statistics     Open Access   (Followers: 1)
American J. of Applied Psychology     Open Access   (Followers: 3)
American J. of Biomedical Research     Open Access   (Followers: 3)
American J. of Cancer Prevention     Open Access   (Followers: 3)
American J. of Civil Engineering and Architecture     Open Access   (Followers: 17)
American J. of Clinical Medicine Research     Open Access   (Followers: 5)
American J. of Educational Research     Open Access   (Followers: 28)
American J. of Electrical and Electronic Engineering     Open Access   (Followers: 10)
American J. of Energy Research     Open Access   (Followers: 6)
American J. of Environmental Protection     Open Access   (Followers: 3)
American J. of Epidemiology and Infectious Disease     Open Access  
American J. of Food and Nutrition     Open Access   (Followers: 2)
American J. of Food Science and Technology     Open Access   (Followers: 2)
American J. of Infectious Diseases and Microbiology     Open Access   (Followers: 14)
American J. of Information Systems     Open Access  
American J. of Materials Engineering and Technology     Open Access  
American J. of Materials Science and Engineering     Open Access  
American J. of Mathematical Analysis     Open Access  
American J. of Mechanical Engineering     Open Access  
American J. of Medical and Biological Research     Open Access   (Followers: 3)
American J. of Medical Case Reports     Open Access  
American J. of Medical Sciences and Medicine     Open Access  
American J. of Medicine Studies     Open Access  
American J. of Microbiological Research     Open Access  
American J. of Modeling and Optimization     Open Access  
American J. of Nanomaterials     Open Access  
American J. of Numerical Analysis     Open Access  
American J. of Pharmacological Sciences     Open Access   (Followers: 1)
American J. of Public Health Research     Open Access   (Followers: 12)
American J. of Rural Development     Open Access   (Followers: 1)
American J. of Sensor Technology     Open Access  
American J. of Sports Science and Medicine     Open Access   (Followers: 1)
American J. of Water Resources     Open Access   (Followers: 1)
American J. of Zoological Research     Open Access  
Applied Ecology and Environmental Sciences     Open Access   (Followers: 10)
Automatic Control and Information Sciences     Open Access  
Biomedical Science and Engineering     Open Access  
Chemical Engineering and Science     Open Access   (Followers: 2)
Intl. J. of Celiac Disease     Open Access   (Followers: 2)
Intl. J. of Dental Sciences and Research     Open Access  
Intl. J. of Econometrics and Financial Management     Open Access  
Intl. J. of Physics     Open Access  
Intl. Transaction of Electrical and Computer Engineers System     Open Access  
J. of Automation and Control     Open Access  
J. of Biomedical Engineering and Technology     Open Access  
J. of Business and Management Sciences     Open Access  
J. of Cancer Research and Treatment     Open Access  
J. of Computer Networks     Open Access  
J. of Computer Sciences and Applications     Open Access  
J. of Environment Pollution and Human Health     Open Access  
J. of Finance and Accounting     Open Access  
J. of Finance and Economics     Open Access   (Followers: 5)
J. of Food and Nutrition Research     Open Access  
J. of Food Security     Open Access  
J. of Geosciences and Geomatics     Open Access  
J. of Materials Physics and Chemistry     Open Access  
J. of Mathematical Sciences and Applications     Open Access  
J. of Optoelectronics Engineering     Open Access  
J. of Polymer and Biopolymer Physics Chemistry     Open Access  
Materials Science and Metallurgy Engineering     Open Access  
Nanoscience and Nanotechnology Research     Open Access   (Followers: 1)
Physics and Materials Chemistry     Open Access  
Research in Plant Sciences     Open Access  
Research in Psychology and Behavioral Sciences     Open Access  
Sustainable Energy     Open Access  
Turkish J. of Analysis and Number Theory     Open Access   (Followers: 1)
Wireless and Mobile Technologies     Open Access  
World J. of Agricultural Research     Open Access   (Followers: 1)
World J. of Analytical Chemistry     Open Access  
World J. of Chemical Education     Open Access  
World J. of Environmental Engineering     Open Access  
World J. of Organic Chemistry     Open Access  
Journal Cover American Journal of Pharmacological Sciences  
   [3 followers]  Follow    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2327-6711 - ISSN (Online) 2327-672X
   Published by Science and Education Publishing Homepage  [72 journals]
  • Anti-inflammatory and Antioxidant Activities of the Methanolic Leaf
           Extract of Cissus aralioides

    • Authors: Maxwell I. Ezeja; Yusuf N.Omeh, Samuel O. Onoja, Ijeoma H. Ukaonu
      Pages: 1 - 6
      Abstract: Inflammation and oxidative stress are features of many degenerative diseases. This study evaluated the anti-inflammatory and antioxidant activities of the methanolic leaf extract of Cissus aralioides in vivo and in vitro. The anti-inflammatory activity was evaluated using the carrageenan and formalin-induced paw edema models and Nitric oxide (NO) scavenging ability, while the antioxidant activity was evaluated using 1, 1-diphenyl-2-picryl hydrazyl (DPPH) photometric assay. In the anti-inflammatory study, doses of 150, 300 and 600 mg/kg of the extract were used orally. Acetylsalicylic acid (200 mg/kg) was used as a reference drug while concentrations of Cissus aralioides extract (CAE) ranging from 25- 800 µg/ml were used for DPPH and NO scavenging ability. In the carrageenan-induced paw edema model, CAE caused dose-dependent increase in percentage edema inhibition, increasing percentage inhibition of edema from 0% in the negative control group to 41% at 6th h at 600 mg/kg. In the formalin-induced paw edema model, CAE significantly (p < 0.05) and dose dependently increased the percentage edema inhibition and decreased the paw edema volumes on day 1. Cissus aralioides extract showed different percentage increase in the nitric oxide scavenging ability, increasing it from 24.94% at 25 µg/ml to 57.41% at 800 µg/ml while in the DPPH assay; CAE caused a concentration dependent increase in antioxidant activity from 1.88% at 25 µg/ml to 52.55% at 400 µg/ml. In conclusion, the results suggest that Cissus aralioides may be of benefit in ameliorating inflammatory and oxidative stress conditions.
      PubDate: 2015-01-09
      Issue No: Vol. 3, No. 1 (2015)
       
  • Effects of Ginkgo biloba Extract on the Oral Bioavailability of Fluoxetine
           and Venlafaxine in Rats

    • Authors: Fatima Adnan Alzubaidi; Saad Abdulrahman Hussain
      Pages: 7 - 12
      Abstract: Since herbal supplements are not evaluated for interactions with other drugs, there are concerns about their interactions with conventional drugs, which are mostly used as multiple drug treatment approach. The present study aims to evaluate the effects of long-term use of Ginkgo biloba (GK) extract on the intestinal absorption of orally administered, single doses of fluoxetine and venlafaxine in rats. AUC calculations and cumulative diffused calculations are utilized for evaluation of physicochemical interactions in vitro. Rats administered 100 and 200 mg/kg of GK extract, and oral bioavailability of single doses of fluoxetine and venlafaxine were evaluated using HPLC method. The results showed that GK extract has no significant effects on the bioavailability of fluoxetine and venlafaxine. Fluoxetine and venlafaxine serum levels are not affected by 100 mg/kg GK extract, while 200 mg/kg significantly increases venlafaxine level, with no effect on that of fluoxetine. In conclusion, GK extract shows no physicochemical interactions with fluoxetine or venlafaxine. Long-term administration of a low dose of GK extract (100 mg/kg) had no significant effect on serum levels of fluoxetine and venlafaxine, while lager dose (200 g/kg) increases significantly only the serum level of venlafaxine, while that of fluoxetine was not affected.
      PubDate: 2015-01-18
      Issue No: Vol. 3, No. 1 (2015)
       
  • Methanolic Root Extract of Calotropis gigantea Induces Apoptosis in Human
           Hepatocellular Carcinoma by Altering Bax/Bcl-2 Expression

    • Authors: Vishnu Priya; Prateek Jain, B. Meenashi Vanathi, P. Vasanth Raj, B. Venkatesh Kamath, J. Venkata Rao, N. Udupa, N. Sivagurunathan
      Pages: 13 - 17
      Abstract: Calotropis gigantea, family apocynaceae, is a milkweed traditionally used in ayurveda for its anti-helminthic, anti-pyretic, and anti-malarial activities. It has also been studied widely for its anticancer potential. In the present study, the antioxidant, antibacterial, antifungal and antitumor potential of its three root extracts viz. chloroform extract (CE), ethyl acetate extract (EE) and methanolic extract (ME) were investigate. Antiproliferative activity of the extracts was examined on human hepatocellular carcinoma cells, HepG2 and human breast cancer cells, MCF-7. Maximum cytotoxicity was obtained with ME on HepG2 cells with IC50 value of 85 µg/mL. ME was further investigated at 85 µg/mL, for cell DNA damage using agarose gel electrophoresis and nuclear staining. RT-PCR analysis was done to study expression of bcl-2 family of genes viz., bax, bcl-2, and p53. Bax expression significantly (p < 0.05) increased following ME treatment, whereas bcl-2 expression was significantly (p < 0.05) lowered. Significant (p < 0.05) increase of p53 expression suggested damage to DNA of HepG2 cells. The study showed that methanolic root extract induces apoptosis in HepG2 cells by altering bax/bcl-2 expression. Further studies are required to obtain knowledge about the complete mechanism of its apoptosis inducing activity.
      PubDate: 2015-01-22
      Issue No: Vol. 3, No. 1 (2015)
       
 
 
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