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Publisher: Universitas Ahmad Dahlan   (Total: 14 journals)   [Sort by number of followers]

Showing 1 - 14 of 14 Journals sorted alphabetically
Ahmad Dahlan J. of English Studies     Open Access   (Followers: 1)
Berkala Fisika Indonesia     Open Access  
HUMANITAS (Jurnal Psikologi Indonesia)     Open Access   (Followers: 4)
Intl. J. of Advances in Intelligent Informatics     Open Access   (Followers: 6)
J. of Education and Learning     Open Access   (Followers: 11)
J. of Education, Health and Community Psychology     Open Access   (Followers: 7)
Jurnal Hukum Novelty     Open Access  
Jurnal Ilmiah AdMathEdu     Open Access  
Jurnal Informatika     Open Access   (Followers: 1)
Jurnal Kesehatan Masyarakat (J. of Public Health)     Open Access   (Followers: 2)
Media Farmasi     Open Access  
Pharmaciana     Open Access  
Psikopedagogia : Jurnal Bimbingan dan Konseling     Open Access   (Followers: 1)
TELKOMNIKA (Telecommunication, Computing, Electronics and Control)     Open Access   (Followers: 8, SJR: 0.211, h-index: 8)
Journal Cover Pharmaciana
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   ISSN (Print) 2088-4559 - ISSN (Online) 2477-0256
   Published by Universitas Ahmad Dahlan Homepage  [14 journals]
  • Antioxidant activity of methanolic extract from yellow paprika (Capsicum
           annuum, L.) by DPPH radical scavenging method

    • Authors: Warsi Warsi, Any Guntarti
      Pages: 123 - 132
      Abstract: Yellow paprika (Capsicum annuumL.) is one of fruit that contains of carotenoid compounds as an antioxidant. This reasearch was aimed to know an antioxidant capacity of methanolic extract from yellow paprika with 2,2–diphenyl–1–picrylhydrazyl (DPPH) radical scavenging method. The fresh yellow paprika was determined of its loss of drying by gravimetric. The yellow paprika extract was obtained by maceration using methanol as solvent. The content of β–carotene from this extract was analyzed qualitively by thin layer chromatography and UV-Vis spectrophotometer. The antioxidant activity of methanolic extract from yellow paprika was determined base on measurement of residual DPPH by UV–Vis spectrophothometric at wavelength of 515.6 nm. The data was used to calculate % inhibition. Furthermore, IC50 value was determined to know potency of its antioxidant. The result of loss of drying yellow paprika fruit was obtained 6.33 ± 0.02 %. The analysis with thin layer chromatography and UV-Vis spectrophotometer showed that this fruit was contain of β–carotene. The result of antioxidant activity analysis from yellow paprika fruit was obtained IC50 value of 0.3028 ± 0.0093 mg/mL. The result of the research showed that the antioxidant potency of yellow paprika was less than β–carotene (IC50 0.0852 ± 0.0009 mg/mL).
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Application method of Fourier Transform Infrared (FTIR) combined with
           chemometrics for analysis of rat meat (Rattus Diardi) in meatballs beef

    • Authors: Any Guntarti, Seshilia Rarasati Prativi
      Pages: 133 - 140
      Abstract: Food product forgery begins to become a new problem in Indonesia, the main problem is there is a concern that food product is mixed with forbidden meat, one of may is rat meat in meatball.  This study is expected to become one basic in order to meet meatball authenticity guarantee.Study about the utilization of infrared spectrophotometry Fourier Transform (FTIR) which was combined with chemometric was carried out to identified rat meat in meatball quantitative and qualitatively. Concentration variation of beef and rat meat in producing meatball is 0%, 25%, 35%, 65%, 75% and 100% rat meat in meatball dough and 5 samples of market meatball. Beef and rat fat which were contained in meatball was extracted by Soxhlet in temperature ≤ 70oC for 7 hours with n-hexane solvent.Qualitative and quantitative analysis was carried out in wave range 750-1600 cm-1 by using partial least square (PLS) multivariate analysis technique and principal component analysis (PCA). The result of calibration with y = 0,9720x + 1,580, coefficient of determination (R2) = 0,9941, and root mean square error of calibration (RMSEC) value was 1.63%. Validation model with, mean root mean square error of cross validation (RMSECV) value was 1.79%, and root mean square error of prediction (RMSEP) value was 2.60%. Using Principal Component Analysis (PCA), grouping of cow fat and mouse fat in the meatballs successfully. 
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Chloroform fraction of ethanolic extract of Elephantopus scaber Linn.
           increase the p53 expression on human breast cancer (T47D) cell line

    • Authors: Nurkhasanah Mahfudh, Nanik Sulistyani, Lukman Mahdi
      Pages: 141 - 146
      Abstract: Elephantopus scaber Linn had been used as traditional medicine. It contain some lacton sesquiterpene with antiproliferative activity. The study aim was to explore the effect of chloroform fraction of ethanolic extract of E.scaber on the expression of p53 on T47D cell line. The ethanol extract was found by maceration method. The extract was then fractionated using petroleum ether and chloroform respectively to get the chloroform fraction. The expression of p53 was observed by immunocytochemistry method with antip53 antibody. The p53 cell line was cultured and treated with fraction with concentration of 7.06 and 3.53 µg/ml. The expression of p53 was showed by brown colour in the nucleus of the cell. The result showed that chloroform fraction treatment with concentration of 7.06 µg/ml induced apoptotic cell death in the end stage (necrosis). While the treatment with lower concentration 3.53 µg/ml could increase the p53 expression.
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Antioxidant activity, determination of total phenolic and flavonoid
           content of Muntingia calabura L. Extracts

    • Authors: Anita Dwi Puspitasari, Ririn Lispita Wulandari
      Pages: 147 - 158
      Abstract: Muntingia calabura L. leaves were contained alkaloids, saponins, phenolic, flavonoids, and tannin. Phenolic and flavonoids compound had antioxidant activity. The present study aims to determine the antioxidant activity, determination of total phenolic and flavonoid content of ethanol extract of Muntingia calabura L. leaves and its fractions. Muntingia calabura L. leaves were macerated with 96% ethanol and then evaporated until ethanol extract was obtained. The ethanol extract was dissolved into water and then partitioned with n hexane and ethyl acetate to obtain the n hexane fraction, ethyl acetate fraction and water fraction. Determination of antioxidant activity of extracts and fractions was performed by free radical capture measurement method by 1,1-diphenyl-2-picrylhydrazyl (DPPH) in vitro. Vitamin C was used as a positive control with IC50 value of        25.74 µg/mL. The total phenolic and flavonoid content were determined using the colorimetric method using standard gallic acid for total phenolics and standard quercetin for flavonoid content. The results showed that ethyl acetat fraction showed the highest antioxidant activity with IC50 79.37 μg/mL value compared to n hexane fraction (101.36 μg/mL), ethanol extract (126.47 μg/mL), and water fraction (129.85 μg/mL). The ethyl acetate fraction contains the highest total phenolic of 510.57 mg GAE/g extract compared to ethanol extract (311.10 mg GAE/g extract), water fraction (292.74 mg GAE/g) extract, and n hexane fraction (103.95 mg GAE/g extract). The ethyl acetate fraction contained the highest flavonoid content of 76.32 mg QE/g extract compared to ethanol extract (39.63 mg QE/g extract), water fraction (14.29 mg QE/g extract) and n hexane fraction (3.30 mg QE/g extract). Total phenolic and total flavonoid levels were positively correlated with antioxidant activity
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Validation of UV-Vis spectrophotometry methode for analysis of apigenin in
           celery extract (Apium graveolens L.)

    • Authors: Asep Nurrahman Yulianto, Taofik Rusdiana, Muchtaridi Muchtaridi, Anas Subarnas
      Pages: 159 - 168
      Abstract: Apigenin is one of the flavonoid compounds contained in celery (Apium graveolens L.) and has been used for the treatment of various diseases. This study aims were to ensure the validity and accuracy of analytical method for apigenin assay in celery extract using UV-Vis spectrophotometry. The flavonoids test of celery extract give a positive result which produces a yellow color that can be drawn by amyl alcohol. The result of TLC test using a mobile phase of chloroform and methanol (9.5 : 0.5) produced Rf value of 0.75. Validation of analytical methods were sensitivity, linearity, limit of detection as well as limit of quantification, accuracy, and precision. Validation of analytical methods showed that sensitivity results as represented by molar extinction (ε) was 77004.35 M-1cm-1. Linearity from calibration curve at concentration of 2, 4, 6, 8, and 10 mgL-1 resulted an equation of y = 0.074x – 0.0011 with coefficient correlation (r) of 0.9996. The limit of detection and limit of quantification were 2.99 mgL-1 and 9.92 mgL-1 respectively with recovery percentage of 97.59% and the coefficient variation values were 1.53%; 2.43% and 1.68%. The average contents of apigenin in the celery extract were of 3.74 ± 0.09%. 
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Analytical method validation and determination of dexamethasone in divided
           powder using reverse phase HPLC

    • Authors: Florentinus Dika Octa Riswanto, Dita Maria Virginia, Dina Christin Ayuning Putri, Sri Hartati Yuliani
      Pages: 169 - 176
      Abstract: Dexamethasone as glucocorticoids has been widely used to reduce inflammation and tissue damage in a variety of conditions. It was commonly prescribed in combination with the other compounds such as chlorpheniramine maleate for the relief of asthma. It was important to observe the quality and safety of the combination dosage form, called pulveres or puyer in order to serve the patient oriented medication. This research aimed to develop analytical method validation and determine the content uniformity of the divided powder containing dexamethasone compounded by pharmacy in Yogyakarta and hospital in Central Java, Indonesia. A validated high performance liquid chromatography (HPLC) method was chosen to determine dexamethasone in the samples. The column of ACE 5 C18 (250 x 4.6 mm) was used in this research and the methanol:water (65:35) was used as the mobile phase at the flow rate of 1 mL/min. The UV detection was performed at 239 nm. Analytical method validation was performed on the parameters of system suitability, limit of detection, limit of quantification, accuracy, precision, and linearity. The results showed that dexamethasone contains in divided powder compounded by pharmacy in Yogyakarta and hospital in Central Java were met the acceptance requirement.  
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Effectiveness of banana leaves extract (Musa paradisiaca L.) for wound
           healing

    • Authors: Prasojo Pribadi, Dimas Ariandi Candra Putra, Heni Lutfiyati
      Pages: 177 - 184
      Abstract: Banana leaves (Musa Paradisiaca, L.) has not been widely used in the treatment purpose of this study was to examine the wound healing activity of the gel of banana leaves (Musa paradiasiaca L.) and determine the most effective concentration for wound healing.Target research is to provide natural wound treatment alternatives. The method used is eksperimental.Prosedur research study began with the identification of a banana leaf, banana leaf extraction, formulation of banana leaf extract gel with a concentration of 1%, 5%, 10% and testing to the test animals were harmed .Animal test are grouped into 5 groups the negative control group (base gel), a positive control (bioplacenton), and 3 groups treatment. Measuring of  diameter wound on day-1 through day 7. The observation was tested by using ANOVA and Post Hoc Tukey HSD. ANOVA test results showed a significant difference between the mean percentage of wound healing all groups Treatment .The result of  Post hoc Tukey HSD at the 95% confidence level showed significant differences in the negative control group when compared to the positive control group and the treatment group gel 5% and 10% .It indicates that the positive control, gel 5% and 10% have a wound healing effect. Positive control group compared with the group treated gel 5% and 10% showed significant differences that the average value of the percentage of wound healing is higher than the positive control treatment group. It means the difference meant that the positive control has better activity. While the group gel 5% when compared with the 10% gel group no significant difference in this case means the group gel 5% with 10% having a comparable effectiveness of wound healing.
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Pakan banyu (Croton argyratus Blume) stembark ethanol extract
           effectiveness to total spermatogenic cells of white male rats (Rattus
           norvegicus)

    • Authors: Noor cahaya, M. Aditya Sholihin, Nurlely Nurlely
      Pages: 185 - 194
      Abstract: Stembark of Pakan Banyu (Croton argyratus Blume) empirically used as traditional contraception. The stembark contained active substances as steroids, saponins and alkaloids tannins alleged antifertillity for men. The purpose of this study was to demonstrate the potential of Pakan Banyu stembark ethanol extract to the total number of spermatogonium cells, primary spermatocytes, spermatids and spermatozoa in male rats. This study was an experimental research design posttest only control group design using 20 male rats into 4 groups of 5 mice. The control rats were used in treatment group, the rats were given the pakan banyu stembark extract at a dose of 100, 200 and 500 mg / kg with 0.5% CMC Na suspending agent. The treatment was given orally for 15 days at the 16th days surgery was done to the testicles organs, then microanatomy preparations were made using paraffin method and using HE colour. Analysis of data using One-way ANOVA and Kruskal Wallis with 95% confidence level. The results showed that there is no effect of Pakan Banyu stembark ethanol extract against spermatogonium cells, primary spermatocytes, spermatids and spermatozoa. 
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Effect of Sargassum polycystum extract on liver and kidney of diabetic
           rats

    • Authors: Muhamad Firdaus, Anies Chamidah, Annafi Riski Nurcholis, Siti Yulaikah, Pangestuty Yeni Anggraeni, Widya Adi Suryanata, Denny Alghafihqi, Rendi Hardiansyah
      Pages: 195 - 204
      Abstract: Hyperglycemia has been known able to incuce the free radical formation. The reactivity of free radical can affect the dysfunction and structural adjustment on liver and kidney of the diabetic. Polyphenol is bioactive that able to ameliorate the reactivity of free radical. This substance is also contained in brown seaweed.One of brown seaweeds that found on the Indonesia waters is Sargassum polycystum. The objective of this study was to evaluate the S. polycystum extract (SPE) to reduce the damage of the function and structure of liver and kidney in diabetic rats. SPE was obtained by drying, milling, extraction by methanol, concentrating, degassing by nitrogen gas, and finally freeze-drying, respectively. The male of rat strain Wistar was induced to diabetic by streptozotocin. This study was divided into four groups, i.e., normal, diabetic, diabetic + gliclazide and diabetic + SPE, respectively. The treatments of this experiment were executed for 45 days. The polyphenol content, malondialdehyde level, SGPT and SGOT levels, and creatinine levels were measured by the spectrophotometer, the blood glucose level was quantified by glucometer, and the insulin content was determined by ELISA method. The altering of the tissue structure was analyzed by staining method of hematoxylin and eosin. The result showed that the treatment of SPE on diabetic rats able to reduce the blood glucose level, malondialdehyde level of liver, and kidney,  SGPT and SGOT level of liver, creatinine level of blood, and increase of insulin level and improve the liver, and kidney tissue profiles, respectively. These results indicate that SPE can reduce the destruction of structure and function on liver and kidney of the diabetics. 
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Factors relate to the hypercreatininemia event of patients at the risk of
           metabolic syndrome in Jetis I public health center

    • Authors: Akrom Akrom, Dr; M.Kes, Endang Darmawan, Nuril Maulida
      Pages: 205 - 216
      Abstract: Metabolic syndrome (MS) is a risk factor for chronic kidney disease (CKD). Adherence to drug therapy is one of the keys to achieving therapeutic targets in MS. Hyperuricemia (>7mg/dL in men &>5.4mg/dL in women) and hypercreatininemia (>1.3 mg/dL) is a sign of kidney function deficiency. Kidney function deficiency is the result of uncontrolled blood pressure and blood sugar levels in MS patients. The objective of the study was to know the description of the incidence of hypercreatininemia and factors related to the incidence of hypercreatininemia in outpatient  at risk of  MS at Jetis Public health center (PHC) I, Bantul, Yogyakarta. The analytical observational research with cross sectional design was performed on 99 MS outpatient at Jetis I Public Health Center (PHC) who fulfilled the inclusion criteria and approved the participation in the study. Blood urea and creatinine levels were determined by spectrophotometer 5010. Demographic, diagnosis and treatment data were colleccted  from medical record. Patient adherence data were collected by interview. Patient compliance was measured by a medication compliance questionnaire. Demographic and clinical  data are presented descriptively. Bivariate analysis with chisquare was performed to determine the value of the relationship between sex, age, hyperuricemia and adherence to the incidence of hypercreatininemia.  About 30.3% of total of outpatients at risk of MS at Jetis I PHC, Bantul, is non-adherence and 69.7% is adherence to the treatment. As many as 44.4% of respondents have hypercreatininemia and 8.1% of respondents have hyperuricemia. There was a relationship between adherence and female sex with the prevalence of hypercreatininemia with an odds ratio of 3.8, 0.26 and 7.1 respectively. Based on the data of the study concluded that non-adherence, male sex and hyperuricemia are associated with the prevalence of hypercreatininemia in patients at risk of MS in Jetis I PHC.
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Analysis of the utilization and cost of antibiotics at an intensive care
           unit in Surabaya

    • Authors: Eko Setiawan, Hidayat Felix, Adji Prayitno Setiadi
      Pages: 217 - 230
      Abstract: The appropriateness of antibiotic utilization including the compatibility when it was mixed with other pharmaceutical products are important factors determining the effectiveness and cost of antibiotics treatment among patients admitted to the intensive care unit (ICU). The aim of this research was to figure out the antibiotics utilization, appropriateness, cost, and compatibility profile given to the inpatients of the intensive care unit in one hospital in Surabaya during November-December 2015. This research was prospective observational study using medical records as source of information. All patients’ data receiving antibiotics that met the inclusion and exclusion criteria was collected and analyzed descriptively. There were 42 patients participated in this research. Analysis of antibiotic utilization profile revealed 46 usage (65.71%) of single antibiotics and 24 usage (34.29%) of combination antibiotics. The most frequently used of antibiotic in single usage was ceftriaxone (43.48%) while in combination were ceftazidime and levofloxacin (12.50%). There were 30 antibiotics treatment changes that 43.34% was classified as escalation process and there was no (0%) any switching from intravenous to oral therapy. Only 4 out of 15 patients with infection related diagnosis (26.67%) got appropriate antibiotic treatment. Moreover, result from compatibility analysis found that 13.96% admixtures between antibiotics and other intravenous pharmaceutical products did not have clear compatibility status. The average of antibiotic cost per-patient was Rp. 459.492 (min-max: Rp 15.852,- to Rp 8.314.914,-).
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Effectiveness of web based educational on improving knowledge of acne
           vulgaris self medication among senior high school students

    • Authors: Lolita Lolita, Ni Putu Isabela Meita Putri
      Pages: 231 - 238
      Abstract: The presence of technology can provide real alternatives to build knowledge in delivering health education materials. The aim of this study was to investigate if web-based education methods may rising a student’s knowledge about self medication of acne. This research using an experimental pretest-posttest control group design while the sampling technique using convenience nonprobability sampling. Inclusion criteria for participants were senior high school students aged 13-19 years, active social media users, and willing to fill out the research questionnaire. Participants were allocated to the exclusion criteria as students who perform routine skin care in the acne treatment. Control group consisted of 62 respondents who were given face to face education and treatment group consisted of 62 respondents who were given website-based education. Data analysis were performed with a student t-test to assess the effect of educational intervention on student’s knowledge. The independent t-test showed there was a significant increase of knowledge between the control and the treatment groups   (p = 0,000) with 95% confidence level. This study demonstrate that web-based educational intervention had a significant increase on the student’s knowledge about acne vulgaris self medication.
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Clearance propile of radioactive gold nanoparticle (198Au)
           conjugates-poliamidoamin generation 4-nimotuzumab ; potential
           radio-pharmaceutical theranostic agent

    • Authors: Nurhatidjah Awaliyah Halid, abdul mutalib, Anung Pujiyanto, Adang Hardi Gunawan
      Pages: 239 - 248
      Abstract: Theranostic agents are agents that combine diagnostic and therapeutic capabilities into a single agent. The presence of conjugated cancer which is therapeutic agents such as nimotuzumab monoclonal antibodies with radioactive gold nanoparticles stabilized with Polyamidoamine Generation 4 (PAMAM G4) dendrimer can actively interact with specific cancer cells. Radioactive gold (198Au) as a radiation transmitter β (961 keV) capable for killing cancer cells and (412 keV) γ rays that give a golden image in the body, thus acting as a theranostic agent. The purpose of this study was to obtain confident results of conjugate safety by observing the constituent clearance of 198AuNP-PAMAM G4-Nimotuzumab. The result of the conjugate clearance will be the reference for the metabolic state as a new, stable and complete radiofarmaka upon reaching the desired target. This study began with the synthesis of the conjugate of 198AuNp-PAMAM G4-nimotuzumab and then tested the clirens and analyzed the results of urine and mouse feces that had been injected with conjugate. Total clearance was obtained about 47.38% of the 198AuNP-PAMAM G4-Nimotuzumab conjugates that have been excreted through urine (18.26%) and stool (29.11%.). Urine and feces were analyzed with SDS-PAGE giving the spot above the 150 kDa band and showing the conjugate molecular weight. FTIR analysis of urine and feces by showing aldehyde functional groups (C = O), alcoholic groups (O-H), amine groups (C-N), and amine groups (N-H) indicating the presence of AuNP-PAMAM G4-Nimotuzumab conjugates in urine and mouse feces. The results of urine and fecal excretion of the conjugate are still conjugate-shaped supported by SDS PAGE analysis, UV-Vis spectrophotometer absorption analysis and functional group analysis with FTIR that has been conducted.
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • In vitro penetration of alpha arbutin niosome span 60 system in gel
           preparation

    • Authors: Rise Desnita, Sri Luliana, sil vana anggraini
      Pages: 249 - 256
      Abstract: Alpha arbutin is a hydrophilic compound which is difficult to pass trough the stratum corneum. One of the effort to increase the penetration of the drug through the stratum corneum is by making in niosome system. This study aims to determine the optimum concentration of span 60 to improve the entrapment efficiency of niosome and investigate the increasing penetration of alpha arbutin using the niosome system in the preparation of the gel in vitro. Niosome consist a mixture of span 60 and cholesterol it made by thin layer hydration method. Concentration of span 60 was varied into three formulas were 100, 150 and 200 µmoL. The formulation of gel was made in two formulas including formulation of niosome alpha arbutin and alpha arbutin in gel. The determination of enterapment efficiency showed that formula 100µmol has an optimum enterapment efficiency by 99.09%±0.1. The in vitro penetration tests with shed snake skin membrane showed that usage span 60 as a niosome composer could increase penetration of alpha arbutin in gel formulation with cumulative numbers of diffusion in 8 hours was 91.62%±2.32 compared to alpha arbutin in gel without niosome system about 73.00%±0.94.7.
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Formulation and antibacterial activity test toothpaste combination of
           triclosan-extract ethanol of suji leaves (Pleomele angustifolia N.E Brown)
           

    • Authors: Elya Zulfa, Rima Andriani
      Pages: 257 - 266
      Abstract: The suji leaf are generally used by the community as a gargle to remove plaque. Toothpaste is one form of dosage suitable for oral health with triclosan active ingredients, but triklosan is corrosive, resistant to bacteria, and decrease the hormonal system, especially the thyroid hormone. The aim of this research is to know the effect of the addition of variation of the concentration of combination of triclosan-ethanol extracts of suji leaf (T-EESL) on toothpaste preparation to the chemical characteristics, antibacterial activity of Streptococcus mutans. The ethanol extract of 70% of suji leaf was obtained by maceration method, then made toothpaste preparation with variation of T-EESL combination of FI (1:0), FII (0,5:0,5), FIII (0:1). Toothpaste was tested chemical physics characteristics (organoleptic, viscosity, pH, and foam power), antibacterial activity test. The test results are analyzed descriptively. Based on the results of the research obtained it can be concluded that the results of testing the physical physics of chemistry showed the results that all toothpaste formulas meet the physical characteristics of chemical toothpaste. T-EESL toothpaste (0.5:0,5) (FII) has strong antibacterial activity against Streptococcus mutans so it can be used as an alternative to the existing dosage preparation in the market with triclosan active substance.  
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Formulation self nano emulsifying drug delivery system glimepiride using
           oleic acid as oil phase

    • Authors: Sani Ega Priani, Nurrayyan Nurrayyan, Fitrianti Darusman
      Pages: 267 - 276
      Abstract: Glimepiride is a third generation sulphonylurea antidiabetic drug. Glimepiride is poorly water soluble drug that may cause poor dissolution and unpredicted bioavailability. Self nanoemulsifying drug delivery systems (SNEDDS) have become a popular formulation option as nanocarriers for poorly water-soluble drugs. The objective of this research was to develop SNEDDS formulation of glimepiride to improve oral dissolution and bioavailability. Glimepiride SNEDDS  was formulated using oleic acid as oil phase, tween 80 as surfactant, and transcutol as co-surfactant due to their higher solubilization effect. The formulated SNEDDS were evaluated for % transmittance, dispersibility, thermodynamic stability, dissolution, globule size and morphology analysis. The results showed that the glimepiride SNEDDS was rapidly formed clear emulsion and stabile based on thermodynamic test. Transmission electron microscopy demonstrated the spherical droplets morphology in nanometer range. The globule average diameter size was 45 nm. The SNEDDS formulation significantly increase dissolution of glimepiride compared with pure drug.
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Antiobesity and antihypercholesterolemic effects of white tea (Camellia
           sinensis) infusion on high-fat diet induced obese rats

    • Authors: Shaum Shiyan, Herlina Herlina, Annisa Mutiara Bella
      Pages: 278 - 288
      Abstract: Obesity may cause the lipid metabolisms disorder so that a risk factor for hypercholesterolemic. Catechin and epigallocatechin gallate in white tea potentially inhibit lipase activity. Caffeine compounds and catechin derivatives have a role as antihypercholesterolemic. The objective of this study was to explore antiobesity and antihypercholesterolemic activity from white tea infusions to lipase and total cholesterol in rats model fed a high-fat-diet. Twenty-five rats were divided into five groups. Negative control group was administered with distilled water. The positive control group was administered with orlistat dose 14.2 mg/kgBW. Group 3rd, 4th, and 5th were treated with white tea infussion doses of 125, 250 and 500 mg/kgBW/day, respectivelly. period and feed intake was calculated daily during the treatment. White tea doses of 500 mg/kgBW decrease the total cholesterol by 37.16±11 mg/dL, lipase level of 23.70±0.64 U/L, weight up to 3.53±1.21 g/day and decrease feed intake by 12.71±1.76 g/day. The infusion of white tea can decrease total cholesterol level, lipase level, body weight and feed intake. This study concluded that infusion of white tea has antiobesity and antihypercholesterolemic effect on rats fed high-fat-diet.
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Cytotoxic effect of 2,3-dihydro-6-hydroxy-2-methylenenaphtho[1,2-b]
           furan-4,5-dione compound from the bark of faloak (Sterculia quadrifida
           R.Br) in breast cancer cells T47D

    • Authors: Rollando rollando, Rokiy Alfanaar
      Pages: 289 - 294
      Abstract: Faloak (Sterculia quadrifida R.Br) is used empirically by residents of East Nusa Tenggara for drug plant. The information of the active compound contained in the faloak bark yet specifically published. This study aims to determine the active compound contained in the faloak bark that have cytotoxic activity to T47D breast cancer cells. Extraction process using maceration method, isolation process using gradien isolation method, elusidation using combination of information of IR spectra, 1D-NMR, 2D-NMR and LC-MS, and cytotoxic activity test on T47D breast cancer cells using MTT method. The isolation result obtained that isolate of naphthoquinone derivative compound is 2,3-dihydro-6-hydroxy-2-methylenenaphtho [1,2-b] furan-4,5-dione with IC50 value on T47D breast cancer cell was 9,88 µg/mL and with an index selectivity value was 30,23. 
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • The determination of metal content, microbial contamination and
           dissolution assessment of the ethanol extract of pasak bumi root

    • Authors: Laela Hayu Nurani, Eka Kumalasari, Zainab Zainab, Achmad Mursyidi, Sitarina Widyarini, Abdul Rohman
      Pages: 295 - 304
      Abstract:  The Eurycoma longifoliais bitter therefore, to address this problem, it is prepared in a capsule form. The capsule dosage form  must has  the parameters of good quality, thus expected to increase the potential use of biodiversity and the interest of the community in consuming the medicine from the natural materials. The purpose of this research is to get the capsule product of ethanol extract of the Eurycoma longifolia root of quality through the test of total plate value and yeast yeast contamination, the determination of the metal content of Pb, Hg, Cd and the level of flavonoids released in the capsule dissolution test of ethanol extract Eurycoma longifolia root. The result of this research shows that the dissolution efficiency (DE120) capability of ethanol extract of Eurycoma longifolia root is 81,04±2,38%. Test of heavy metal content in capsule of  of ethanol extract of Eurycoma longifolia root found level of Pb equal to 4,132 ppm and not detected content of Cd and Hg in capsule. This indicates that the capsule meets the requirements set by BPOM RI. Tests for total plate numbers (ALT) and yeast capsule ethanol extract of the E. longifolia root were each obtained data of 70 x 102 colonies / g and 4 x 102 colonies / g. It also shows that the capsules meet the requirements by BPOM RI.
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
  • Comparison of antioxidant activities from four species of piper

    • Authors: Muhamad Insanu, Lia Marliani, Nabila Pandu Dinilah
      Pages: 305 - 312
      Abstract: Some species from Piper genus were known for traditional medicine and ornamental plant. Previous studies showed that Piper betle and Piper acre had antioxidant activities. But, the study of antioxidant activity from other species of Piper was still limited. Because of that, the purposes of this study were to determine the antioxidant activity, and total flavonoid content of Piper nigrum, Piper aduncum, Piper retrofractum, and Piper crocatum. Extraction was done by gradient maceration using n-hexane, ethyl acetate, and ethanol as solvents. The extracts were concentrated by rotary evaporator. Antioxidant activity was evaluated by DPPH (1,1-diphenyl-2-picrylhydrazyl) free scavenging method. Total flavonoid determination was done by colorimetry method using aluminum chloride (AlCl3) as a reagent. The result showed that the IC50 values of Piper nigrum, Piper aduncum, Piper retrofractum, and Piper crocatum were ranged between 58-1249 μg/mL. The total flavonoid values of all extracts were between 1.4-8.3 mg QE/100 mg. The extract which had the strongest antioxidant activity was the ethanol extract of Piper nigrum with an IC50 value was  57.72 μg/mL. The highest values of total flavonoid was showed by the ethanol extract of Piper aduncum which was 8.3 mg QE/100 mg extract.
      PubDate: 2017-11-20
      Issue No: Vol. 7, No. 2 (2017)
       
 
 
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