Publisher: BMC (Biomed Central)   (Total: 316 journals)

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Showing 201 - 316 of 316 Journals sorted alphabetically
Intl. J. of Retina and Vitreous     Open Access   (Followers: 2)
Investigative Genetics     Open Access   (Followers: 1, SJR: 1.809, CiteScore: 3)
Irish Veterinary J.     Open Access   (Followers: 4, SJR: 0.657, CiteScore: 1)
Israel J. of Health Policy Research     Open Access   (SJR: 0.488, CiteScore: 1)
Italian J. of Pediatrics     Open Access   (Followers: 2, SJR: 0.685, CiteScore: 2)
J. of Angiogenesis Research     Open Access   (Followers: 2)
J. of Animal Science and Biotechnology     Open Access   (Followers: 7, SJR: 1.228, CiteScore: 3)
J. of Animal Science and Technology     Open Access   (Followers: 3)
J. of Biological Engineering     Open Access   (Followers: 3, SJR: 1.34, CiteScore: 4)
J. of Biological Research - Thessaloniki     Open Access   (SJR: 0.32, CiteScore: 2)
J. of Biomedical Semantics     Open Access   (Followers: 2, SJR: 0.952, CiteScore: 2)
J. of Cardiothoracic Surgery     Open Access   (Followers: 5, SJR: 0.607, CiteScore: 1)
J. of Cardiovascular Magnetic Resonance     Open Access   (Followers: 1, SJR: 2.292, CiteScore: 5)
J. of Clinical Movement Disorders     Open Access   (Followers: 3)
J. of Congenital Cardiology     Open Access   (Followers: 4)
J. of Cotton Research     Open Access  
J. of Diabetes and Metabolic Disorders     Open Access   (Followers: 8, SJR: 0.818, CiteScore: 2)
J. of Eating Disorders     Open Access   (Followers: 9, SJR: 0.693, CiteScore: 1)
J. of Environmental Health Science & Engineering     Open Access   (Followers: 1, SJR: 0.802, CiteScore: 3)
J. of Ethnobiology and Ethnomedicine     Open Access   (SJR: 0.693, CiteScore: 3)
J. of Experimental & Clinical Cancer Research     Open Access   (Followers: 2, SJR: 2, CiteScore: 6)
J. of Foot and Ankle Research     Open Access   (Followers: 5, SJR: 0.873, CiteScore: 2)
J. of Health, Population and Nutrition     Open Access   (Followers: 9, SJR: 0.875, CiteScore: 2)
J. of Hematology & Oncology     Open Access   (Followers: 3, SJR: 2.292, CiteScore: 6)
J. of Inflammation     Open Access   (Followers: 2, SJR: 1.101, CiteScore: 3)
J. of Intensive Care     Open Access   (Followers: 7, SJR: 1.137, CiteScore: 3)
J. of Medical Case Reports     Open Access   (Followers: 1, SJR: 0.331, CiteScore: 1)
J. of Molecular Psychiatry     Open Access   (Followers: 9, SJR: 0.355, CiteScore: 0)
J. of Nanobiotechnology     Open Access   (Followers: 4, SJR: 1.38, CiteScore: 5)
J. of Negative Results in BioMedicine     Open Access   (SJR: 0.483, CiteScore: 1)
J. of Neurodevelopmental Disorders     Open Access   (SJR: 1.71, CiteScore: 4)
J. of NeuroEngineering and Rehabilitation     Open Access   (Followers: 14, SJR: 1.515, CiteScore: 5)
J. of Neuroinflammation     Open Access   (Followers: 2, SJR: 2.336, CiteScore: 5)
J. of Occupational Medicine and Toxicology     Open Access   (Followers: 13, SJR: 0.591, CiteScore: 2)
J. of Orthopaedic Surgery and Research     Open Access   (Followers: 7, SJR: 0.751, CiteScore: 2)
J. of Otolaryngology - Head and Neck Surgery     Open Access   (Followers: 10, SJR: 0.827, CiteScore: 2)
J. of Ovarian Research     Open Access   (SJR: 1.008, CiteScore: 3)
J. of Pharmaceutical Policy and Practice     Open Access   (Followers: 4, SJR: 0.545, CiteScore: 1)
J. of Physiological Anthropology     Open Access   (Followers: 9, SJR: 0.514, CiteScore: 2)
J. of the Intl. AIDS Society     Open Access   (Followers: 10, SJR: 2.092, CiteScore: 4)
J. of the Intl. Society of Sports Nutrition     Open Access   (Followers: 57, SJR: 0.775, CiteScore: 2)
J. of Therapeutic Ultrasound     Open Access   (SJR: 0.906, CiteScore: 3)
J. of Translational Medicine     Open Access   (Followers: 4, SJR: 1.565, CiteScore: 4)
J. of Trauma Management & Outcomes     Open Access   (Followers: 6, SJR: 0.398, CiteScore: 1)
J. of Venomous Animals and Toxins including Tropical Diseases     Open Access   (Followers: 1, SJR: 0.573, CiteScore: 2)
Kidney Disease and Transplantation     Open Access   (Followers: 4)
Lipids in Health and Disease     Open Access   (SJR: 0.915, CiteScore: 2)
Longevity & Healthspan     Open Access   (Followers: 1)
Malaria J.     Open Access   (Followers: 8, SJR: 2.082, CiteScore: 3)
Marine Biodiversity Records     Open Access   (Followers: 4, SJR: 0.354, CiteScore: 1)
Measurement Instruments for the Social Sciences     Open Access  
Microbial Cell Factories     Open Access   (Followers: 8, SJR: 1.443, CiteScore: 4)
Military Medical Research     Open Access   (Followers: 4, SJR: 0.601, CiteScore: 2)
Mobile DNA     Open Access   (SJR: 3.783, CiteScore: 5)
Molecular Autism     Open Access   (Followers: 10, SJR: 2.377, CiteScore: 5)
Molecular Brain     Open Access   (Followers: 3, SJR: 1.805, CiteScore: 4)
Molecular Cancer     Open Access   (Followers: 4, SJR: 2.778, CiteScore: 7)
Molecular Cytogenetics     Open Access   (Followers: 1, SJR: 0.623, CiteScore: 1)
Molecular Neurodegeneration     Open Access   (Followers: 2, SJR: 3.418, CiteScore: 7)
Movement Ecology     Open Access   (Followers: 10, SJR: 2.242, CiteScore: 4)
Multidisciplinary Respiratory Medicine     Open Access   (Followers: 4, SJR: 1.13, CiteScore: 2)
Multiple Sclerosis and Demyelinating Disorders     Open Access   (Followers: 5)
Neural Development     Open Access   (Followers: 2, SJR: 1.821, CiteScore: 2)
NeuroCommons     Open Access   (Followers: 1)
NeuroMetals     Open Access  
Neuropsychiatric Electrophysiology     Open Access  
Neurovascular Imaging     Open Access  
Nutrition & Metabolism     Open Access   (Followers: 11)
Nutrition J.     Open Access   (Followers: 7, SJR: 1.447, CiteScore: 4)
One Health Outlook     Open Access   (Followers: 1)
Orphanet J. of Rare Diseases     Open Access   (Followers: 1, SJR: 1.413, CiteScore: 3)
Particle and Fibre Toxicology     Open Access   (Followers: 2, SJR: 2.253, CiteScore: 8)
Patient Safety in Surgery     Open Access   (Followers: 4, SJR: 0.525, CiteScore: 1)
Pediatric Rheumatology     Open Access   (Followers: 7, SJR: 0.729, CiteScore: 2)
Philosophy, Ethics, and Humanities in Medicine     Open Access   (Followers: 2, SJR: 0.285, CiteScore: 1)
Pilot and Feasibility Studies     Open Access   (Followers: 1)
Plant Methods     Open Access   (Followers: 2, SJR: 1.885, CiteScore: 4)
PMC Biophysics     Open Access  
Population Health Metrics     Open Access   (Followers: 6, SJR: 1.954, CiteScore: 3)
Porcine Health Management     Open Access  
Proteome Science     Open Access   (Followers: 1, SJR: 0.792, CiteScore: 2)
Public Health Reviews     Open Access   (Followers: 2, SJR: 0.454, CiteScore: 1)
Radiation Oncology     Open Access   (Followers: 6, SJR: 1.293, CiteScore: 3)
Renal Replacement Therapy     Open Access   (Followers: 4)
Reproductive Biology and Endocrinology     Open Access   (Followers: 4, SJR: 1.203, CiteScore: 3)
Reproductive Health     Open Access   (Followers: 2, SJR: 1.228, CiteScore: 2)
Research Involvement and Engagement     Open Access  
Respiratory Research     Open Access   (Followers: 1, SJR: 1.644, CiteScore: 4)
Retrovirology     Open Access   (SJR: 1.855, CiteScore: 3)
Safety in Health     Open Access   (Followers: 68)
Scandinavian J. of Trauma, Resuscitation and Emergency Medicine     Open Access   (Followers: 13, SJR: 0.618, CiteScore: 2)
Scoliosis     Open Access   (Followers: 3)
Scoliosis and Spinal Disorders     Open Access   (Followers: 1, SJR: 0.843, CiteScore: 2)
Signals     Open Access   (Followers: 1)
Skeletal Muscle     Open Access   (Followers: 1, SJR: 2.32, CiteScore: 4)
Source Code for Biology and Medicine     Open Access   (SJR: 0.784, CiteScore: 2)
Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology     Open Access   (Followers: 17)
Stem Cell Research & Therapy     Open Access   (Followers: 10, SJR: 1.685, CiteScore: 5)
Substance Abuse Treatment, Prevention and Policy     Open Access   (Followers: 8, SJR: 1.108, CiteScore: 2)
Sustainable Earth     Open Access  
Systematic Reviews     Open Access   (Followers: 11, SJR: 1.794, CiteScore: 4)
Theoretical Biology and Medical Modelling     Open Access   (Followers: 1, SJR: 0.783, CiteScore: 2)
Thrombosis J.     Open Access   (Followers: 5, SJR: 1.009, CiteScore: 3)
Thyroid Research     Open Access   (Followers: 1, SJR: 0.329, CiteScore: 1)
Tobacco Induced Diseases     Open Access   (Followers: 9, SJR: 0.716, CiteScore: 2)
Translational Neurodegeneration     Open Access   (Followers: 1, SJR: 1.901, CiteScore: 5)
Trials     Open Access   (Followers: 4, SJR: 1.291, CiteScore: 2)
Tropical Diseases, Travel Medicine and Vaccines     Open Access   (Followers: 1)
Urban Transformations     Open Access   (Followers: 1)
Vascular Cell     Open Access   (SJR: 1.349, CiteScore: 4)
Veterinary Research     Open Access   (Followers: 12)
Virology J.     Open Access   (Followers: 7, SJR: 1.053, CiteScore: 2)
Women's Midlife Health     Open Access   (Followers: 1)
World Allergy Organization J.     Open Access   (Followers: 1, SJR: 1.936, CiteScore: 6)
World J. of Emergency Surgery     Open Access   (Followers: 5, SJR: 1.098, CiteScore: 3)
World J. of Surgical Oncology     Open Access   (Followers: 1, SJR: 0.688, CiteScore: 2)

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Journal of Diabetes and Metabolic Disorders
Journal Prestige (SJR): 0.818
Citation Impact (citeScore): 2
Number of Followers: 8  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2251-6581
Published by BMC (Biomed Central) Homepage  [316 journals]
  • Rapid degradation of ABCA1 protein following cAMP withdrawal and treatment
           with PKA inhibitor suggests ABCA1 is a short-lived protein primarily
           regulated at the transcriptional level

    • Abstract: Objectives ATP-binding cassette transporter A1 (ABCA1) is a key player in the reverse cholesterol transport (RCT) and HDL biogenesis. Since RCT is compromised as a result of ABCA1 dysfunction in diabetic state, the objective of this study was to investigate the regulation of ABCA1 in a stably transfected 293 cells expressing ABCA1 under the control of cAMP response element. Methods To delineate transcriptional and posttranscriptional regulation of ABCA1, 293 cells were stably transfected with the full length ABCA1 cDNA under the control of CMV promoter harboring cAMP response element. cAMP-mediated regulation of ABCA1 and cholesterol efflux were studied in the presence of 8-Br-cAMP and after withdrawal of 8-Br-cAMP. The mechanism of cAMP-mediated transcriptional induction of the ABCA1 gene was studied in protein kinase A (PKA) inhibitors-treated cells. Results The transfected 293 cells expressed high levels of ABCA1, while non-transfected wild-type 293 cells showed very low levels of ABCA1. Treatments of transfected cells with 8-Br-cAMP increased ABCA1 protein by 10-fold and mRNA by 20-fold. Cholesterol efflux also increased in parallel. Withdrawal of 8-Br-cAMP caused time-dependent rapid diminution of ABCA1 protein and mRNA, suggesting ABCA1 regulation at the transcriptional level. Treatment with PKA inhibitors abolished the cAMP-mediated induction of the ABCA1 mRNA and protein, resulting dampening of ABCA1-dependent cholesterol efflux. Conclusions These results demonstrate that transfected cell line mimics cAMP response similar to normal cells with natural ABCA1 promoter and suggest that ABCA1 is a short-lived protein primarily regulated at the transcriptional level to maintain cellular cholesterol homeostasis.
      PubDate: 2020-03-19
  • Improving effect of combined inorganic nitrate and nitric oxide synthase
           inhibitor on pancreatic oxidative stress and impaired insulin secretion in
           streptozotocin induced-diabetic rats

    • Abstract: Purpose The aim of this study was to evaluate the effect of dietary nitrate on secretory function of pancreatic islet and oxidative stress status in streptozotocin (STZ) induced type 1 diabetes in absence or presence of nitric oxide synthase inhibitor (L-NAME). Methods Fifty adult male sprague-dawly rats were divided into 5 groups: controls (C), diabetes (D), diabetes+nitrate (DN), diabetes +L-NAME (D + Ln), and diabetes+nitrate+L-NAME (DN + Ln) for 45 days. The concentrations of sodium nitrate and L-NAME were respectively 80 mg/L in drinking water and 5 mg/kg intraperitoneally. Body weight gain, plasma levels of glucose and insulin, islet insulin secretion and content, lipid peroxidation and antioxidant status in the pancreas of rats were determined. Results Compared to control group, the body weight gain and plasma insulin level were significantly decreased and plasma glucose and pancreatic NO and MDA concentrations and antioxidant enzymes activities were significantly increased in the STZ diabetic rats. In the diabetic rats, nitrate alone significantly reduced plasma glucose and increased pancreatic SOD and GPx activity. Reduced plasma glucose, pancreatic MDA and NO concentrations and increased plasma insulin level and pancreatic islet insulin secretion were observed in D + Ln and DN + Ln groups. Antioxidant enzymes activities were increased in diabetic rats which received combination of nitrate and L-NAME. Conclusions Our results showed that nitrate without effect on pancreatic islet insulin content and secretion decreased the blood glucose and slightly moderate oxidative stress and its effects in the presence of L-NAME on glucose hemostasis and pancreatic insulin secretion higher than those of nitrate alone.
      PubDate: 2020-03-18
  • Transcranial direct current stimulation improves quality of life and
           physical fitness in diabetic polyneuropathy: a pilot double blind
           randomized controlled trial

    • Abstract: Purpose Diabetes Mellitus (DM) is a chronic disease which presents a big prevalence in the world and several patients with this condition fail to respond to the available treatments. There is a huge unmet clinical need for the development of new therapeutic approaches for this condition. This study aims to evaluate the effects of anodal tDCS on Quality of Life and physical fitness in patients with diabetic polyneuropathy. Methods A pilot, parallel, sham, randomized, double-blind trial was conducted with twenty patients. Five consecutive sessions of C3/Fp2 tDCS montage were performed. To assess the primary outcome Short Form 36 Health Survey (SF-36) was used. Physical fitness level, according to lower and upper body strength, flexibility, Time Up and Go Test (TUG) and Six-Minute Walking Test (6MWT) were measured as secondary outcomes. The measures were performed at 3 different times (baseline, 1st and 2nd weeks). Results SF-36 increased throughout the protocol, but no difference between groups were found. However, there was a significant difference between groups at 1st and 2nd weeks, which shows a permanent growth in the active-tDCS group. Physical health and functioning, functional capacity and bodily pain showed significant improvements in active-tDCS group in 1st and 2nd weeks during inter-group analysis. Emotional scores showed significant interaction group-time with interaction effects only for active-group in 1st and 2nd weeks. TUG and 6MWT showed significant improvements only in active-tDCS group. Conclusions It is suggested that five sessions of anodal M1 tDCS improves QoL and functionality of patients with diabetic polyneuropathy.
      PubDate: 2020-03-14
  • Involvement of fat mass and obesity gene (FTO) in the anti-obesity action
           of Annona muricata Annonaceae: in silico and in vivo studies

    • Abstract: Background Annona muricata (Annonaceae) known as soursop is a common tropical plant species known for its numerous medicinal properties including obesity. The underlying mechanism of anti-obesity effect of A. muricata was investigated. The fat mass and obesity associated protein (FTO) is a validated potential target for anti-obesity drugs. Methods The interaction of compounds previously characterized from A. muricata was investigated against FTO using Autodock Vina. Also, modulation of FTO and STAT-3 mRNA expression by A. muricata was investigated in high fat diet induced obese rats (HFDR) using RT-PCR. Results A significant up-regulation of FTO gene was observed in HFDR when compared to control rats, while administration of A. muricata (200 mg/kg) significantly (p < 0.05) down-regulated FTO gene expression when compared to HFDR group. The effect of obesity on STAT-3 gene expression was also reversed by A. muricata (200 mg/kg). In silico study revealed annonaine and annonioside (−9.2 kcal/mol) exhibited the highest binding affinity with FTO, followed by anonaine and isolaureline (−8.6 kcal/mol). Arg-96 is a critical amino acid enhancing anonaine, isolaureline-FTO binding. Conclusion This study suggests the possible anti-obesity mechanism of A. muricata is via down-regulation of FTO with concomitant up-regulation of STAT-3 genes. This study confirmed the use of this plant in the management of obesity and the probable compounds responsible for its antiobesity effect are annonaine and annonioside.
      PubDate: 2020-03-12
  • Evaluation of skin absorption of the Citrullus colocynthis in treatment of
           type II diabetic patients

    • Abstract: Background and purpose Nowadays, among the herbal medicines utilized to treat diabetes, Citrullus colocynthis (CCT) is highly noticeable as it reduces blood glucose (BG) and stimulating insulin secretion. However, long-term oral consumption of this herbal medicine has often associated with digestive complications. In this study, skin absorption of CCT as a new therapeutic approach in the treatment of type II diabetic patients has been surveyed. Materials and methods 40 patients with type II diabetic (aged 45–65) were selected. Participants were asked for placing their metatarsus daily in a decoction containing 2% CCT solution for 40–60 min each day and continuing that for 10 days. Blood and urine samples of patients collected at the beginning and the end of the study. The samples were examined for the BG levels, serum insulin content, lipid profiles, hepatic enzymes, urea, creatinine, and microalbuminuria, The quantitative insulin sensitivity check index (QUICKI), Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), homeostasis model assessment of β-cell function (HOMA-β) and disposition index (DI) indicators were also calculated. Results Local treatment of CCT could significantly decrease BG levels, stimulate insulin secretion and improve the function of pancreatic beta cells. It also decreased serum urea levels comparing to pre-treatment levels (p < 0.05) but there was no significant change in creatinine levels, lipid profiles, hepatic enzymes, micro-albuminuria, and other insulin sensitivity indexes. Conclusion This study demonstrated that the CCT plant can also have systemic therapeutic effects on type II diabetic patients through dermal absorption.
      PubDate: 2020-03-07
  • Chromium Supplementation; Negotiation with Diabetes Mellitus,
           Hyperlipidemia and Depression

    • Abstract: Chromium (Cr) is an essential trace element which found naturally in a daily diet and available in the form of supplementary tablets to boost disorders like diabetes mellitus (DM) and functions like lipid metabolism and beneficial on depression too. Diabetes is one of the most prevalent endocrine diseases or in other words, the most severe metabolic syndrome (MS), which associated with high production of free-radicals which is out of bodies detoxifying machine capacity or high oxidative stress (HOS), vasculitis and elevated lipid profile. many research papers and clinical trials published about the significance of chromium on biological activities, pre and post clinical. For this review research articles, clinical trials, from 1st Jan’10 to 31st Dec’18 and refer literature for the biochemical, pharmacological and biological activity of Chromium. Primarily articles gathered from the above search engines. Then precisely according to our aim and goal and regarding designed objectives dismisses similar articles and finally came to 84 articles for the above said period. This review trying to cover the entire picture from what chromium is to the recent updates on their greater role in increasing insulin sensitivity of cells and enhancing lipid metabolism and even recent findings suggest its positive effects including prevention and ameliorating properties on depression. The biological activities, pharmacological features, clinical implications including efficacy and role of chromium compounds on the glycaemic index will be discussed. The outcome of this review is to bring the pros and cons of chromium supplementation along with is safety and toxicity concern beside molecular pathways, biochemistry and clinical trials, all in one comprehensive review.
      PubDate: 2020-03-05
  • Birjand longitudinal aging study (BLAS): the objectives, study protocol
           and design (wave I: baseline data gathering)

    • Abstract: Objectives The pace of population aging is growing rapidly around the world. Aging is associated with the emergence of different health status including geriatric syndrome such as frailty, diabetes, cardiovascular diseases, and dementia. These conditions are the most prominent challenges for health care systems and also elderly people. Therefore, understanding these changes can help scientists to prevent and treat significant health issues and also improve the functional ability of older adults. Methods This is a protocol of the first wave of Birjand Longitudinal Aging Study that is an ongoing community-based prospective cohort study with a following up at least 10 years. This study carries out on aged population ≥ 60 years which were residents in Birjand County (urban and rural older subjects). The selection of the participants of this study in urban areas is based on an age group weighted multistage stratified random sample while in the rural region the sample was selected from all ten rural regions of Birjand County by simple random sampling. The rural region sampling was based on the list of the aged population which were under the coverage of the rural health center. Sociodemographic, past medical history, lifestyle, sleep, activities of daily living, cognitive function, quality of life, and social capital were evaluated by interviewing with the participants and one of the informants. Anthropometric measures, electrocardiography, and interpretation of ophthalmologic examination were carried out by experts. Fasting Blood samples were collected and bio-banked in − 80 °C. then finally biochemical and hematologic markers were measured. Results This is the protocol of stage one baseline of Birjand Longitudinal Aging Study (BLAS). The BLAS is an enjoining study, the first phase of its baseline was carried out on a community- dwelling aged population sample ≥ 60 years who were residents in urban and rural regions of Birjand County. This is a community based prospective cohort study with at least 10 years follow up of participants. The data for 65% of older subjects (response rate = 65%) that lived in clusters were collected. Conclusions This study can help scientists to recognize some risk factors related to the aging process and also aware policymakers about the necessity to create heath care services at regional and even national levels.
      PubDate: 2020-03-05
  • Safety and efficacy of Berberis integerrima root extract in patients with
           type 2 diabetes. A parallel intervention based triple blind clinical trial

    • Abstract: Purpose To evaluate the safety and efficacy of methanol extract of Berberis integerrima root on type 2 diabetes compared to metformin. Methods In a parallel triple blind clinical trial, 80 type 2 diabetic patients,, were randomized into two groups (treated with Berberis integerrima root, 480 mg (oral), compared to control group treated with metformin 1000 mg daily). Efficacy was evaluated by fasting and prandial glucose and HbA1c and side effects confirmed by physical examination, biology and hematology tests and urinalysis on days 15, 45 and 90. They were followed for 3 months. Results Two hundred and eighteen patients were recruited and 80 (55female and 25 male) patients randomized in two groups and 60 patient were analysed. The mean age of patients was 51.8 ± 9.3 and 46.5 ± 10 in the experimental (Berberis integerrima) and control (metformin) groups respectively (P = 0.02). The mean HbA1c at baseline was 8.1 ± 1.6% and 7.9 ± 1.6% for B. integerrima and metformin group respectively (P = 0.53), and there was no significant difference between the two groups (7.5 vs. 7.2) after 3 months (P = 0.34). Weight loss was observed in both groups compared to baseline. No adverse event led to preventing the study was reported. Conclusion Berberis integerrima root not only was effective as much as metformin in reducing blood glucose and controlling type 2 diabetes but also, no specific side effect was reported (in short term).So, it might be an effective and safe complementary therapy in diabetic patients. Iranian Research and Clinical Trial (IRCT) registeration number; 201,207,191,774 N5. Funding: Vice chancellor for research, Physiology Research Center of Kerman University of Medical Sciences and the Exir pharmaceutical company.
      PubDate: 2020-03-04
  • The effects of mindfulness training on the level of happiness and blood
           sugar in diabetes patients

    • Abstract: Purpose The present study aimed at investigating the effect of mindfulness training on the level of happiness and blood glucose in diabetic patients in Zarghan city, Iran. Methods This quasi-experimental study was conducted in 2018 in Fars province, Iran. 136 diabetic patients who were eligible (had diabetes for more than one year, older than 18 years, willingness to participate in the research, and reside in Zarqan city) were selected based on convenience sampling method. Next the participants were randomly divided into two groups, each comprising 68 individuals. Both of the study samples and statistical analyser were blinded to intervention group (mindfulness training) and control group (without intervention). Before and three month after the intervention the patients’ levels of happiness (based on Oxford Happiness Questionnaire), fasting blood sugar (FBS) and Glycated Hemoglobin test (HbA1c) were measured. Results The results indicated that after the sessions, the level of happiness in the Intervention group was significantly higher than the control group (p value <0.001). Also, the level of blood glucose and HbA1c after the sessions was significantly lower in the Intervention group compared to the control group (p value<0.001, p value = 0.004). After the intervention, there was a significant correlation between mean blood glucose levels and mean HbA1c levels in the Intervention group and their level of happiness (p value<0.01 and p value<0.001). Conclusion The findings revealed that the mindfulness-based educational intervention can increase happiness in people with diabetes and regulate their blood glucose.
      PubDate: 2020-03-02
  • Diabetes affects hepatic and renal glycoproteins: effect of Boswellia
           ovalifoliolata on glycoproteins proportions in diabetes induced hepatic
           and renal injury

    • Abstract: Purpose Chronic hyperglycemia and deficiency of insulin are peculiar features of diabetes mellitus alters glycoprotein levels in various tissues leads to impaired metabolism of glycoproteins which play a major role in the pathogenesis of diabetic complications. Boswellia ovalifoliolata is a medicinal plant known for its many medicinal properties including diabetes. In this background our study was aimed to evaluate the effect of aqueous extract of stem bark of Boswellia ovalifoliolata (AESBBO) on antidiabetic and glycoprotein metabolism. Methods Diabetes was induced in rats by intraperitoneal administration of streptozotocin at a dose of 50 mg/kg bw. After induction of diabetes rats were treated with AESBBO at dosage of 200 mg/kg for a long term treatment of 40 days. Finally, by the end of study all the rats were dissected blood, liver, and kidney tissue samples were collected to investigate the long term effects of AESBBO on diabetes and glycoprotein metabolism. Results Treatment with AESBBO significantly reduced the fasting blood glucose levels whereas the levels of insulin and hemoglobin were increased with decreased levels of glycosylated hemoglobin. The long term treatment of AESBBO significantly decreased the levels of plasma, liver and kidney tissue glycoproteins such as fucose, hexose, hexosamine and sialic acid. Conclusions This study concludes that the aqueous extract of stem bark of Boswellia ovalifoliolata possesses a protective role on abnormal glycoprotein metabolism in addition to its antihyperglycemic activity.
      PubDate: 2020-02-25
  • High-dose thiamine supplementation may reduce resting energy expenditure
           in individuals with hyperglycemia: a randomized, double – blind
           cross-over trial

    • Abstract: Background Despite the crucial role of thiamine in glucose and energy metabolism pathways, there has been no published study examining the impact of thiamine on energy metabolism in humans. Objective To assess the effects of thiamine supplementation on resting energy expenditure (REE) in individuals with hyperglycemia. Methods Twelve hyperglycemic patients completed this double-blind, randomized trial, where all participants received both thiamine (300 mg/day) and matched placebo for 6 weeks in a cross-over manner. REE was assessed by indirect calorimetry. Anthropometric measurements, fasting and 2-h plasma glucose, and glucose-induced thermogenesis were also assessed at the beginning and on the completion of each six-week phase. Results Participants consuming thiamine supplements experienced a significant decrease in the REE assessed at week six compared to the baseline [mean (SE): 1478.93 (73.62) vs.1526.40 (73.46) kcal/d, p = 0.02], and the placebo arm (p = 0.002). These results did not change significantly after adjusting for the participants’ body weight and physical activity as potential confounders. Six-week intervention had no significant effect on the participants’ body weight or waist circumference, in either supplement or placebo arms (all p values>0.05). However, correlation analysis highlighted significant positive relationships between the changes in REE, and those in fasting (rs = 0.497, p = 0.019) and 2-h plasma glucose (rs = 0.498, p = 0.018) during the six-week intervention period. Conclusion Supplementation with high-dose thiamine may attenuate REE in patients with impaired glucose regulation. Our findings suggest that the impact of thiamine on REE may in part be explained by improved glycemic control. Trial registration Australian New Zealand Clinical Trials Registry ACTRN12611000051943.'ACTRN=12611000051943
      PubDate: 2020-02-22
  • A rare case of sever primary hypoparathyroidism presented with amnesia and
           basal ganglia calcification

    • Abstract: Objectives The aim of this study was to describe clinical findings in a 45-year-old man with history of two sided cataract surgery, convulsions and progressive memory impairment. Methods The patient presented to the neurology department because of having progressive memory impairment over the past two years. After taking necessary examinations the patient was referred to the endocrine center because of hypocalcemia in laboratory tests. Brain CT scan and MRI was also done. Results Brain CT scan of patient showed extensive and symmetric calcification of basal ganglia, thalami and cerebellum. On Brain MRI, abnormal signal foci in the both sided paraventricular regions, basal ganglia and cerebellar hemisphere were depicted. Laboratory investigations were notable for low serum calcium (5.4 mg/dl, reference range: 8.2–11.2), high serum phosphorus (7.6 mg/dl, reference range: 2.7–4.5), vitamin D deficiency (25-OH D3: 14.5 ng/ml) and low parathyroid hormone (IPTH: 3.7 pg/mL, reference range: 10–62). Conclusions This patient presented with amnesia which is a rare presentation of hypoparathyroidism.
      PubDate: 2020-02-21
  • Stimulatory effects of Lactobacillus casei derived extracellular vesicles
           on toll-like receptor 9 gene expression and cytokine profile in human
           intestinal epithelial cells

    • Abstract: Background A complex community of microorganisms in the gastrointestinal (GI) tract, known as the gut microbiota, exerts major effects on gene expression and cytokine profile. Extracellular vesicles (EVs) which are produced by bacteria could be sensed by Toll like receptors (TLRs). The interaction between gut microbiota and TLRs affects homeostasis and immune responses. In this study, we evaluated TLR9 gene expression and cytokines level in Caco-2 cell line treated with Lactobacillus casei as one of the gut microbiota and its EVs. Methods In the present study, L. casei derived EVs was extracted via ultracentrifugation. The quality control assessment included the evaluation of physicochemical characteristics of EVs. For the treatment of Caco-2 cell line, L. casei and its EVs (100 and 150 μg/mL) were used. In addition, qRT-PCR assay was carried out to evaluate the mRNA expression of TLR9 gene. ELISA assay was also performed to determine the levels of IFNγ, TNF-α, GM-CSF, IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-12, IL-17A, and IL-10 cytokines. Results The results showed that L. casei slightly increased TLR9 gene expression in the Caco-2 cell line. It was also found that EVs at concentrations of 100 and 150 μg/mL could significantly decrease TLR9 gene expression. Furthermore, L. casei significantly increased IL-10 and IFNγ levels. Based on the findings, the level of IL-17A, as a proinflammatory cytokine, decreased by L. casei. Both concentrations of EVs decreased the level of IFNγ, while increasing the concentrations of IL-4 and IL-10. EVs from L. casei could modulate immune responses in the Caco-2 cell line. Both EVs and L. casei activated the expression and secretion of several cytokines. Conclusions L. casei and its EVs have pivotal role in the cross talk between gut microbiota and the host especially in the modulation of the immune system. This study shows for the first time the increasing level of anti-inflammatory cytokines by EVs released by L. casei. Based on the last studies on immunomodulatory effect of EVs on immune cells and our results in cell line level, we postulate that L. casei derived EVs could be possible candidates for the reduction of immune responses.
      PubDate: 2020-02-20
  • Mediterranean diet for patients with non-alcoholic fatty liver disease, a
           systematic review and meta-analysis of observational and clinical

    • Abstract: Aim Mediterranean diet (MD) is a healthful dietary pattern with benefits for prevention of metabolic diseases including non-alcoholic fatty liver disease (NAFLD). In the current meta-analysis, we assessed the association between MD and liver steatosis and cardiometabolic risk factors in patients with NAFLD. Methods PubMed, Scopus, and Embase were searched to find observational and clinical studies on the issue. No restriction on date and language was made. Outcomes included body mass index (BMI), waist circumference, blood pressure, triglycerides (TG), cholesterol fractions, glucose, insulin, insulin resistance, and liver transaminases. Results Seven observational reports and 6 trials met our inclusion criteria and entered in the meta-analysis. In observational studies, there was an inverse association between MD and NAFLD (effect size (ES) = 0.95; 95% CI: 0.90, 1.00; P = 0.05). In trials, subgroup analysis based on the method of liver examination showed effectiveness of MD on steatosis examined by magnetic resonance spectroscopy (P < 0.002; n = 2) but not by ultrasound (P = 0.08; n = 2). MD also showed a significant decreasing effect on BMI (ES = −1.23 kg/m2; 95% CI: −2.38, −0.09), plasma triglycerides (ES = −33.01 mg/dL; 95% CI: −52.84, −13.18), and HOMA-IR (ES = -0.94; 95% CI: −1.29, −0.58) but no significant effect was observed in waist circumference, cholesterol fractions, glucose and insulin, and liver transferases. Conclusion Overall, available data from observational and clinical studies indicated a trend for the relationship between MD and hepatic steatosis. Improvement in the most important risk factors of NAFLD, i.e. BMI, serum triglycerides, and insulin resistance, may be involved in such relationship.
      PubDate: 2020-02-17
  • New insights on strain-specific impacts of probiotics on insulin
           resistance: evidence from animal study

    • Abstract: Background and aims сomparative animal study of effectiveness of intermittent administration of lyophilized single-, three- and alive multistrain probiotic in short courses on insulin resistance (IR) in rats with experimental obesity. Methods 70 rats were divided into 7 groups (n = 10 in each). Rats of group I were left intact. Newborn rats in groups II-VII were administered monosodium glutamate (MSG) (4 mg/g) by injection. Rats in group II (MSG-obesity group) were left untreated. The rats in groups III-V received lyophilized mono-probiotics B.animalis VKL, B.animalis VKB, L.casei IMVB-7280 respectively. The rats in group VI received all three of these probiotic strains mixed together. Group VII was treated with multi-probiotic “Symbiter”, containing 14 different live probiotic strains (Lactobacillus, Bifidobacterium, Propionibacterium, Acetobacter genera). Results Treatment of newborn rats with MSG lead to the development of obesity in all MSG-obesity rats and up to 20–70% after probiotic administration. Additions to probiotic composition, with preference to alive strains (group VII), led to significantly lower rates of obesity, decrease in HOMA-IR (p < 0.001), proinflammatory cytokines levels – IL-1β (p = 0.003), IL-12Bp40 (p < 0.001) and elevation of adiponectin (p = 0.003), TGF-β (p = 0.010) in comparison with MSG-obesity group. Analysis of results in groups treated with single-strain probiotics (groups III-V) shows significant decrease in HOMA-IR, but changes were less pronounced as compared to mixture groups and did not achieve intact rats level. Other metabolic parameters were not affected significantly by single strains. Conclusion Our findings provide major clues for how to design and use probiotics with more efficient compositions in obesity and IR management and may bring new insights into how host-microbe interactions contribute to such protective effects.
      PubDate: 2020-02-16
  • An exploratory study of relationship between lower-limb muscle mass and
           diabetic polyneuropathy in patients with type 2 diabetes

    • Abstract: Purpose This exploratory study compared the lower-limb muscle mass (thigh muscle mass [TMM] and lower-leg muscle mass [LLMM]) in type 2 diabetic patients with and without diabetic polyneuropathy (DPN). Methods A total of 130 patients with type 2 diabetes, hospitalized for glycemic control, were enrolled in this cross-sectional study. TMM and LLMM were measured using the bioelectrical impedance method. The muscle mass value was normalized by the bodyweight, and the total muscle mass was calculated by combining the muscle mass on the left and right (%TMM and %LLMM). DPN was evaluated according to the Japanese criteria. Anthropometric parameters, blood pressure, laboratory data, exercise habits, medication, related index of diabetes, and diabetic complications were analyzed. Results Sixty patients, comprising of 32 males (47.8%) and 28 females (44.4%) with type 2 diabetes (46.2%), had DPN. The %TTM and %LLMM were significantly lower in type 2 diabetic patients with DPN than in those without DPN. Multiple regression analysis identified DPN, age, and hemoglobin A1c (HbA1c) as the determinants of %TMM, and DPN and HbA1c were identified as the determinants of %LLMM in type 2 diabetic patients. Discussion The %TMM and %LLMM were significantly decreased in type 2 diabetic patients with DPN. DPN was found to be the strongest determinant of %TMM and %LLMM. Preventing and improving DPN, through active physical therapy, may increase the muscle mass of the lower limbs.
      PubDate: 2020-02-14
  • Assessing agreement between the three common clinical measurement methods
           of HbA1c

    • Abstract: Reliable measurement of hemoglobin A1c (HbA1c) has great importance in the diagnosis and monitoring of diabetes mellitus. The aim of the present study was to compare the performance parameters of the three common methods of HbA1c assay, including the Roche, Sebia and TOSOH G8 systems. We studied 120 patients referred to a clinical laboratory for HbA1c assay. The blood samples were analyzed with the Roche, Sebia and TOSOH G8 systems based on immunoassay, capillary electrophoresis, and ion-exchange chromatography techniques, respectively. The Spearman and the Passing-Bablok regression,as well as the Bland-Altman plots, were used to compare these methods. For each assay, the patients’ classification was evaluated at the three cut-points of 6.5, 7, and 8% and the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the methods were estimated. Our results showed that there were good correlations and agreement between the methods. We found a mean difference of 0.07% for the TOSOH G8 vs. Roche, 0.06% for the TOSOH G8 vs. Sebia and − 0.01% for the Roche vs. Sebia. The methods represented very low bias, indicating the good accuracy of the results. The sensitivity and specificity of the methods were comparable as well. The three methods also performed similarly in the classification of patients at the proposed cut-off points. Based on our results, the Roche, Sebia and TOSOH G8 systems showed a very high level of agreement with comparable performance parameters and yielded similar and accurate classification of diabetic patients. Therefore, these methods can be used interchangeably.
      PubDate: 2020-02-11
  • Main gut bacterial composition differs between patients with type 1 and
           type 2 diabetes and non-diabetic adults

    • Abstract: Background Regarding the role of gut microbial dysbiosis in hyperglycemia, we aimed to compare the main gut bacterial composition among type 1 and type 2 diabetic patients and healthy non-diabetic adults. Methods A total of 110 adult subjects (49 patients diagnosed with type 2 diabetes, 21 patients diagnosed with type 1 diabetes and 40 healthy persons) were included in this case-control study. The intestinal microbiota composition was investigated by quantitative real-time polymerase chain reaction (qPCR) method targeting bacterial 16S rRNA gene. Comparison between three groups was done using one-way analysis of variance. Results The participants’ mean age in the type 1 diabetes, type 2 diabetes and control groups was 35.4, 57.2 and 38.0 years, respectively. Higher level of Escherichia, Prevotella and Lactobacillus was observed in both type 1 and type 2 diabetic patients compared with the healthy group (P ˂0.001). In contrast, bacterial load of Bifidobacterium, Roseburia and Bacteroides was higher in healthy control group (P < 0.05). Faecalibacterium was significantly lower in type 1 diabetic patients compared with the other two groups (P ˂0.001). No significant difference was found in Akkermansia level among three groups. Conclusions Gut microbial alterations have been observed among patients suffering from type 1 and type 2 diabetes mellitus and healthy control adults. Butyrate producing genera including Roseburia and Faecalibacterium decreased while Escherichia, Prevotella and Lactobacillus increased in diabetic patients compared to healthy subjects. Modulating approaches of gut microbiota composition could be helpful in diabetes management.
      PubDate: 2020-02-08
  • Correction to: Adjusted tight control blood glucose management in diabetic
           patients undergoing on pump coronary artery bypass graft. A randomized
           clinical trial

    • Abstract: The article ‘Adjusted tight control blood glucose management in diabetic patients undergoing on pump coronary artery bypass graft. A randomized clinical trial’, written by Fatemeh Javaherforoosh zadeh and Simin Azemati, was originally published electronically on the publisher’s internet portal.
      PubDate: 2020-02-07
  • Association of serum sestrin 2 and betatrophin with serum neutrophil
           gelatinase associated lipocalin levels in type 2 diabetic patients with
           diabetic nephropathy

    • Abstract: Purpose Understanding the pathogenesis and the molecular mechanisms of diabetic nephropathy (DN) helps its timely detection and prevention. The current work aims tomeasure serum sestrin 2 and betatrophin levels in healthy and type diabetic (T2DM)subjects with/or without diabetic nephropathy (DN) and also to test their correlation with serum neutrophil gelatinase associated lipocalin (sNGAL); indicator of DN. Methods This study included 96 subjects; 20 healthy (G1) and 76 T2DM [22 normoalbuminuric (G2), 35 microalbuminuric (G3) and 19 macroalbuminuric (G4)]. Serum sestrin 2, betatrophin and NGAL were measured by their corresponding kits. Results Significant low levels of serum sestrin 2 andhigh levels of serum betatrophin were found in T2DM group when compared to G1 (p = 0.002,p > 0.001, respectively) and this difference is manifested in G4 followed, in order, by G3, G2 then G1 (p= > 0.001 for both). Also, serum sestrin2 levels showed significant negative correlations with sNGAL in G1 (r = −0.497, p = 0.026), G2 (r = −0.784, p > 0.001), G3 (r = −0.894, p > 0.001) and G4 (r = −0.896, pp. > 0.001) while serum betatrophin levels showed significant positive correlations with sNGAL in G2 (r = 0.681, p > 0.001), G3 (r = 0.518, p > 0.001) and G4 (r = 0.727, p > 0.001). Conclusion Serum sestrin 2 levels decrease significantly while betatrophin levels increase significantly in T2DM patients with DN especially those with macroalbuminuria. These levels have significant effect strengths on the indicator of diabetic nephropathy; sNGAL which might indicate theirvaluablerole in the timely detection and prevention of the development of DN.
      PubDate: 2020-02-06
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Heriot-Watt University
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