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Publisher: Medknow Publishers   (Total: 429 journals)

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Showing 1 - 200 of 429 Journals sorted alphabetically
Acta Medica Intl.     Open Access   (SJR: 0.101, CiteScore: 0)
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advanced Biomedical Research     Open Access  
Advances in Human Biology     Open Access   (Followers: 3)
Advances in Skeletal Muscle Function Assessment     Open Access  
African J. for Infertility and Assisted Conception     Open Access  
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.25, CiteScore: 1)
African J. of Trauma     Open Access   (Followers: 1)
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Alexandria J. of Pediatrics     Open Access  
Ancient Science of Life     Open Access   (Followers: 5)
Anesthesia : Essays and Researches     Open Access   (Followers: 10)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.258, CiteScore: 1)
Annals of Bioanthropology     Open Access   (Followers: 4)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.308, CiteScore: 1)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery     Open Access  
Annals of Indian Psychiatry     Open Access  
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 8, SJR: 0.352, CiteScore: 1)
Annals of Saudi Medicine     Open Access   (SJR: 0.238, CiteScore: 1)
Annals of Thoracic Medicine     Open Access   (Followers: 6, SJR: 0.524, CiteScore: 1)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 13, SJR: 0.152, CiteScore: 0)
Annals of Tropical Pathology     Open Access  
Apollo Medicine     Open Access  
APOS Trends in Orthodontics     Open Access  
Arab J. of Interventional Radiology     Open Access  
Archives of Cardiovascular Imaging     Open Access   (Followers: 1, SJR: 0.187, CiteScore: 0)
Archives of Intl. Surgery     Open Access   (Followers: 10, SJR: 0.302, CiteScore: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Medicine and Surgery     Open Access  
Archives of Pharmacy Practice     Open Access   (Followers: 6, SJR: 0.102, CiteScore: 0)
Archives of Trauma Research     Open Access   (Followers: 3, SJR: 0.37, CiteScore: 2)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 4)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.856, CiteScore: 2)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.35, CiteScore: 1)
Asian Pacific J. of Reproduction     Open Access   (SJR: 0.227, CiteScore: 1)
Asian Pacific J. of Tropical Biomedicine     Open Access   (Followers: 2, SJR: 0.491, CiteScore: 2)
Asian Pacific J. of Tropical Medicine     Open Access   (Followers: 1, SJR: 0.561, CiteScore: 2)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
Biomedical and Biotechnology Research J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Canadian J. of Rural Medicine     Full-text available via subscription   (SJR: 0.202, CiteScore: 0)
Cancer Translational Medicine     Open Access   (Followers: 2)
Cardiology Plus     Open Access  
Chinese Medical J.     Open Access   (Followers: 10, SJR: 0.52, CiteScore: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Cancer Investigation J.     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 2)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 10, SJR: 0.811, CiteScore: 2)
Contemporary Clinical Dentistry     Open Access   (Followers: 4, SJR: 0.353, CiteScore: 1)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.543, CiteScore: 1)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.152, CiteScore: 0)
Dental Research J.     Open Access   (Followers: 11, SJR: 0.416, CiteScore: 1)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 6, SJR: 0.242, CiteScore: 0)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1, SJR: 1.799, CiteScore: 2)
Egyptian J. of Chest Diseases and Tuberculosis     Open Access   (Followers: 3, SJR: 0.155, CiteScore: 0)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.127, CiteScore: 0)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Nursing J.     Open Access  
Egyptian Orthopaedic J.     Open Access   (Followers: 2)
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.822, CiteScore: 2)
Environmental Disease     Open Access   (Followers: 3)
Eurasian J. of Pulmonology     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.749, CiteScore: 2)
European J. of General Dentistry     Open Access   (Followers: 1, SJR: 0.12, CiteScore: 0)
European J. of Prosthodontics     Open Access   (Followers: 3)
European J. of Psychology and Educational Studies     Open Access   (Followers: 11, SJR: 0.113, CiteScore: 0)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.112, CiteScore: 0)
Genome Integrity     Open Access   (Followers: 3, SJR: 0.153, CiteScore: 0)
Glioma     Open Access  
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Gynecology and Minimally Invasive Therapy     Open Access   (SJR: 0.311, CiteScore: 1)
Hamdan Medical J.     Open Access  
Heart and Mind     Open Access  
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
Ibnosina J. of Medicine and Biomedical Sciences     Open Access  
IJS Short Reports     Open Access  
Imam J. of Applied Sciences     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.478, CiteScore: 1)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (Followers: 1, SJR: 0.361, CiteScore: 1)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.37, CiteScore: 1)
Indian J. of Critical Care Medicine     Open Access   (Followers: 3, SJR: 0.604, CiteScore: 1)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.266, CiteScore: 1)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.468, CiteScore: 1)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 5, SJR: 0.445, CiteScore: 1)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1, SJR: 0.791, CiteScore: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4, SJR: 0.568, CiteScore: 1)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.425, CiteScore: 1)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.503, CiteScore: 1)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.656, CiteScore: 1)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.102, CiteScore: 0)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.347, CiteScore: 1)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.23, CiteScore: 0)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 3, SJR: 0.225, CiteScore: 1)
Indian J. of Ophthalmology     Open Access   (Followers: 4, SJR: 0.498, CiteScore: 1)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 8, SJR: 0.392, CiteScore: 1)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.199, CiteScore: 0)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.454, CiteScore: 1)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 2, SJR: 0.276, CiteScore: 1)
Indian J. of Pharmacology     Open Access   (SJR: 0.412, CiteScore: 1)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.311, CiteScore: 0)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.408, CiteScore: 1)
Indian J. of Psychological Medicine     Open Access   (SJR: 0.368, CiteScore: 1)
Indian J. of Public Health     Open Access   (Followers: 1)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Respiratory Care     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.119, CiteScore: 0)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.34, CiteScore: 0)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Transplantation     Open Access  
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Indian Spine J.     Open Access  
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intervention     Open Access   (Followers: 1)
Intl. Archives of Health Sciences     Open Access  
Intl. J. of Abdominal Wall and Hernia Surgery     Open Access   (Followers: 1)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Clinicopathological Correlation     Open Access  
Intl. J. of Community Dentistry     Open Access  
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1, SJR: 0.192, CiteScore: 0)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 3, SJR: 0.142, CiteScore: 0)
Intl. J. of Growth Factors and Stem Cells in Dentistry     Open Access  
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 6)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.535, CiteScore: 1)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4, SJR: 0.17, CiteScore: 0)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 2)
Intl. J. of Orofacial Biology     Open Access   (Followers: 1)
Intl. J. of Orofacial Research     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.623, CiteScore: 1)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 5, SJR: 0.653, CiteScore: 1)
Intl. J. of the Cardiovascular Academy     Open Access   (SJR: 0.105, CiteScore: 0)
Intl. J. of Trichology     Open Access   (SJR: 0.4, CiteScore: 1)
Intl. J. of Yoga     Open Access   (Followers: 14)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 5)

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Journal Cover
Biomedical and Biotechnology Research Journal
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2588-9834 - ISSN (Online) 2588-9842
Published by Medknow Publishers Homepage  [429 journals]
  • Probiotics: The marvelous factor and health benefits

    • Authors: S Vijayaram, S Kannan
      Pages: 1 - 8
      Abstract: S Vijayaram, S Kannan
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):1-8
      The aim of this study is well stated to address in recent advances on probiotics in the past 50 years. Probiotics are the living cell organisms. It is a presence in human and animal gut. The probiotic organisms are natural antibiotics in the human-animal gut. This reviews the main role mechanisms of action in probiotics such as probiotics are antibiotics, probiotics in antibacterial activity, probiotic action in fish gut bacteria, dietary supplements of probiotics, gastrointestinal microbiota of fishes, microbial community of the gastrointestinal tract of fish, bioactive compounds from probiotic bacteria, probiotic uses in cancer therapeutic applications, and applications of probiotics. The most common probiotics are used in many ways such as boosting the immune system, inhibition of pathogenic organism, prevention of cancer, reduction of inflammatory bowel disease, reducing cholesterol level, and synthesis of Vitamin A. Nowadays, food products are mainly involved in chemical preservatives. These preservative agents are causing the disease to affect the human health. The probiotic food products are used to the development of human-animal health.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):1-8
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_87_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Exploring potential of phage therapy for tuberculosis using model organism

    • Authors: Vijay Singh Gondil, Sanjay Chhibber
      Pages: 9 - 15
      Abstract: Vijay Singh Gondil, Sanjay Chhibber
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):9-15
      Antibiotics, one of the miracle discoveries of the 20th century after world war revolutionized the treatment and prophylaxis of infectious diseases. Antibiotics led to an increase in the quality of health-care system but with the emergence of antibiotic-resistant bacterial strains compromised their very potential. The WHO calls bacterial resistance as one of the major threats to global health, food security, and development today. Antibiotic resistance poses a need of alternative therapy to conventional antibiotics. As proved in preantibiotic era phage therapy is effective against a number of successful pathogens and can be used as an alternative strategy to restrain stern infections such as antibiotic resistance tuberculosis (TB). In the present paper, effectiveness of phage therapy and use of model organisms for developing treatment strategy for antibiotic-resistant TB is discussed so as to explore new possibilities in battle against antibiotic resistance.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):9-15
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_93_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Anti-tuberculosis therapy: Urgency for new drugs and integrative approach

    • Authors: Lingaraja Jena, Bhaskar C Harinath
      Pages: 16 - 19
      Abstract: Lingaraja Jena, Bhaskar C Harinath
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):16-19
      Tuberculosis (TB) remains the major health problem causing morbidity and mortality throughout the world. Increase in multidrug resistant, extensively drug-resistant, and totally drug-resistant cases of tuberculosis are causing concern to the health administrators of TB control programs. In spite of tremendous research on drug targets and drugs in TB, no new drug which is safer and more effective, has come out. This mini-review focuses on different important drug targets in Mycobacterium tuberculosis reported and emphasizes the urgency for new drug development and integrative approach for successful control of TB.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):16-19
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_108_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Advances in protein tertiary structure prediction

    • Authors: Tayebeh Farhadi
      Pages: 20 - 25
      Abstract: Tayebeh Farhadi
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):20-25
      Proteins are composed of linear chains of amino acids that form a unique three-dimensional structure in their native environment. Such native structure favors the proteins to perform their biochemical activity. Protein is formed of some levels of structure. The primary structure of a protein is specified by the particular amino acid sequence. In an amino acid sequence, patterns of local bonding can be identified as secondary structure. The final level that forms a tertiary protein structure is composed of the mentioned elements and form after the protein folds into its native state. To find the native structure of proteins, the physicochemical principles as well as identifying the lowest free-energy states are considered as the best properties and to predict target proteins with unknown structures, the bioinformatics-based methods have earned considerable success. Protein structure prediction methods have been mainly classified into three types: ab Initio folding, comparative (homology) modeling and threading. Each mentioned method may be applied for a protein structure, depending on the existence of related experimental structures that are deposited in the PDB. Once an initial model is generated, refinement simulations are conducted to reassemble the global topology and the local structures of the protein chains. Since significant features of a model may be in regions that are structurally distinct from the template, refining of a primary model is influential. A trustful strategy is included a stereo-chemical check and discovering how the model deviates from the basic disciplines of known experimental structures.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):20-25
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_94_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Construction and genetic improvement of copper bioreporter Escherichia
           Coli

    • Authors: Kimia Taghavi, Puria Motamed Fath, Saman Hosseinkhani, Mohammad Mirzaei, Hadi Behrooj, Arda Kiani, Atefeh Abedini, Fatemeh Razavi
      Pages: 26 - 30
      Abstract: Kimia Taghavi, Puria Motamed Fath, Saman Hosseinkhani, Mohammad Mirzaei, Hadi Behrooj, Arda Kiani, Atefeh Abedini, Fatemeh Razavi
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):26-30
      Background: Copper is a pollutant compound which can cause earnest toxicity in human and some organisms. Bioreporters are frugal and non-toxic detectors for pollution compounds. Precedent designed recombinant Escherichia coli copper bioreporters with the lux gene of Vibrio fischeri or Aequorin luciferase of Jellyfish does not provide a high sensitivity. The aim of current study was to design an incipient Copper bioreporter with applying firefly luciferase and Copper resistance promoter of P. syringae pv.Tomato in Escherichia coli XL1-Blue. Methods: Recombinant pGL3 was obtained by applying the pGL3-Control vector to Escherichia coli XL1-Blue, by Polymerase Chain Reaction method and double digestion. Recombinant Escherichia coli cells were cultured with applying different concentrations of copper sulphate to study the activity of luciferase by Luminometer. Copper bioreporter specificity was resolute by different concentrations of Zinc sulfate and Ferric sulfate. Results: Recombinant Escherichia coli BL21, with copper promoter gene in pGL3 Vector showed the highest Luciferase activity in 0.1 millimolar of Copper sulfate. The highest Luciferase activity was in 0.09 millimolar and 1.0 millimolar of Zinc sulfate and Ferric sulfate respectively. Conclusion: Current study provided a categorical bioreporter for detecting copper, utilizing firefly luciferase with a high specificity (96.1%). By optimizing inhibitor factors, application of current copper bioreporter can be developed in human life.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):26-30
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_65_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Identification and development of oxoquinazoline derivatives as novel
           mycobacterial inhibitors targeting cell wall synthesis enzyme

    • Authors: Prasanthi Malapati, Krishna Siva Vagolu, Dhramarajan Sriram
      Pages: 31 - 38
      Abstract: Prasanthi Malapati, Krishna Siva Vagolu, Dhramarajan Sriram
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):31-38
      Background: Tuberculosis (TB) still remains the leading cause of death worldwide and was unanswered till date. Available treatment strategies have many drawbacks such as longer treatment period, side effects, and drug interactions, which result in patient noncompliance. In the present work, we thrived to develop inhibitors against unexplored key target glutamate racemase. Methods: Lead was identified from in-house database using differential scanning fluorimetry, inhibitors were developed by lead derivatization technique and evaluated them by various biological assays. Results: In oxoquinazoline series, compounds 18 (10.1 ± 0.62 μM) and 22 (5.23 ± 0.34 μM) were found to be the most promising potent inhibitors among all. These compounds also showed their inhibition on replicating and nonreplicating bacteria. Conclusion: Our attempt to develop the potent novel inhibitors against Mycobacterium tuberculosis resulted in developing few promising inhibitors, yet these compounds need further studies to answer all questions in drug discovery. Further optimization of compounds can result in still better compounds for treating TB.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):31-38
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_101_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Outdoor air pollution affects tuberculosis development based on
           geographical information system modeling

    • Authors: Esmaeil Rajaei, Maryam Hadadi, Majid Madadi, Jafar Aghajani, Mohanad Mohsin Ahmad, Poopak Farnia, Jalaledin Ghanavi, Parissa Farnia, Ali Akbar Velayati
      Pages: 39 - 45
      Abstract: Esmaeil Rajaei, Maryam Hadadi, Majid Madadi, Jafar Aghajani, Mohanad Mohsin Ahmad, Poopak Farnia, Jalaledin Ghanavi, Parissa Farnia, Ali Akbar Velayati
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):39-45
      Background : Daily intake of air is 30 Ib as compared with 2-Ib of food and 4½ of water. Thereby, breathing-contaminated air is as harmful as drinking or eating contaminated water or food, respectively. Recent research has highlighted the extent of outdoor air pollution in large cities and warranted high-quality studies to clarify the magnitude of the problem. Here, we evaluated the possible association between tuberculosis (TB) development and exposure to outdoor air pollution in a metropolitan city of Tehran. Methods: Extraction and analysis of relevant data. Investigation performed on TB patients (n = 1167) that were residing in Tehran for the past 10 years. The average concentration of sulfur dioxide (SO2), nitrogen dioxide, carbon monoxide (CO), and particles with an aerodynamic diameter of ≤ 2.5μm (PM2.5) and ≤ 10.0 (PM10) was measured from Tehran Air Quality Control Corporation (TAQCC). Patient and ecological informations were analyzed using geographical information system. Results: Based on TAQCC, Tehran had an average of 180–250 polluted days per year for the last 10 years. The high incidence of pulmonary TB (18 to 31/100,000) was detected in populations which were exposed to high concentration of CO (2.7 to 5.2 parts per million, 95% confidence interval [CI]; 1.10 to 1.90) and PM2.5(35 to 42μg/m3; 95% CI 1.03 to 1.80). The level of SO2,NO, and PM10was also high but not significantly related to TB (P > 0.05). Conclusion: The long-term exposure to PM2.5 and CO was positively associated with TB development.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):39-45
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_5_18
      Issue No: Vol. 2, No. 1 (2018)
       
  • Comparative study of LoopampTM Mycobacterium tuberculosis Complex Kit for
           Rapid Detection of Mycobacterium tuberculosis complex in cameroon

    • Authors: Valerie Flore Donkeng Donfack, Laure Ngando, Eric Walter Yone Pefura, Dieudonné Shubesi Che, Ghislaine Ateba, Jean Joel Rim Bigna, Jean Louis Abena Foe, Christopher Kuaban, Sara Eyangoh
      Pages: 46 - 52
      Abstract: Valerie Flore Donkeng Donfack, Laure Ngando, Eric Walter Yone Pefura, Dieudonné Shubesi Che, Ghislaine Ateba, Jean Joel Rim Bigna, Jean Louis Abena Foe, Christopher Kuaban, Sara Eyangoh
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):46-52
      Background: The most practical test for identifying tuberculosis (TB) in developing countries remains smear microscopy. However, due to its low sensitivity, a new point-of-care diagnostic method has been developed. The purpose of this study was to assess the performance of TB-Loop-mediated isothermal amplification (TB-LAMP) test on sputum samples of suspected TB cases. Methods: Suspected pulmonary TB patients (527) from Jamot Hospital and without any history of anti-TB treatment were consecutively included in the study. Smear microscopy, TB-LAMP, GeneXpert® MTB/RIF, and liquid culture using BACTEC 960 Mycobacteria Growth Indicator Tube (MGIT) were performed on sputum samples collected from these patients. The sensitivity and specificity of TB-LAMP were compared with smear microscopy and GeneXpert® MTB/RIF. MGIT culture was the gold standard. Results: TB-LAMP and smear microscopy showed sensitivities of 82.6% (95% confidence interval [CI], 76.9–87.2) and 53.6% (95% CI, 46.8–60.3), respectively, and specificities of 96.0% (95% CI, 93.2–97.7) and 99.0% (95% CI, 97.1–99.7), respectively. The sensitivity and specificity of TB-LAMP were similar to GeneXpert®, (89.9%; 95% CI, 85.0–93.3 and 97.0%; 95% CI, 94.4–98.4). Conclusion: TB-LAMP is more sensitive than currently used microscopy. It presents a favorable diagnostic tool for TB in peripheral laboratories with limited equipment, such as those in developing countries.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):46-52
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_86_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Studies on 3H-levamisole binding to murine splenic lymphocytes, normal,
           malignant human lymphocytes and fate of levamisole in cell culture

    • Authors: B Nageshwari, Ramchander Merugu
      Pages: 53 - 58
      Abstract: B Nageshwari, Ramchander Merugu
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):53-58
      Background: Levamisole at high concentrations has been shown to have anticancer and immunosuppressive actions. Methods: In the present study, fate of levamisole in cell culture and 3 H-levamisole binding to murine splenic lymphocytes, normal and malignant human lymphocytes has been investigated. Results: High-performance liquid chromatography analysis of cell culture supernatants of myeloma cells treated with levamisole has shown that products of levamisole appeared with progressive culture period indicating a metabolic transformation. 3 H-levamisole binding assays indicate that the binding was signifi cantly higher in lysates of lipopolysaccharide-stimulated murine splenic lymphocytes as compared to whole cells. Conclusion: The degradation of levamisole could be one more possible reason for the high concentration of levamisole required to get the desirable cytotoxic effect on myeloma cells.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):53-58
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_106_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Cytotoxicity effects of endodontic irrigants on permanent and primary cell
           lines

    • Authors: Manikandan Ravinanthanan, Mithra N Hegde, Veena Shetty, Suchetha Kumari
      Pages: 59 - 62
      Abstract: Manikandan Ravinanthanan, Mithra N Hegde, Veena Shetty, Suchetha Kumari
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):59-62
      Background: Irrigants plays a vital role in disinfection of the root canal system. Although concentration dependent, a fine balance between antimicrobial efficacy and biocompatibility need to be maintained at all times. The aim of the present study was to evaluate the cytotoxicity of conventional irrigants on two different cell lines in a dose-dependent manner in vitro. Methods: Sodium hypochlorite (NaOCl), chlorhexidine digluconate (CHX), and iodine potassium iodide (IKI) were prepared in concentrations of 5%, 2.5%, 2%, and 1%. About 0.9% saline served as negative control and Biopure MTADTM (100%) as positive control. Permanent (Henrietta Lacks [HeLa]) and primary (human gingival fibroblast [HGF]) cell lines were chosen to evaluate the cytotoxicity of the irrigants by trypan blue assay. A volume of 30 μl of the cell suspension was treated with 20 μl of irrigants. The cell suspension was loaded into Neubauer chamber after 5 min, and cell count was performed under inverted microscope and expressed as viability percentage. Results: NaOCl at all concentrations was cytotoxic on both cell lines; MTAD on HeLa had nonviable scores with limited viability on HGF. Only 1% IKI had better viability than higher concentrations. Although 1% CHX had higher viability on both cell lines, bactericidal concentration of 2% CHX showed promising results. Conclusion: Target cell line (HGF) appears to be more sensitive than the use of nontarget cell line (HeLa) for evaluating cytotoxicity. NaOCl and MTAD were cytotoxic and should be used with caution. Lower concentrations of CHX appear to be less cytotoxic than any irrigant and concentrations tested.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):59-62
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_92_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • A comparison of three diagnostic platforms for the detection of influenza
           A and B in children

    • Authors: Furqan Kabir, Marvi Tariq, Fatima Aziz, Syed Imran Rizvi, Shahida Qureshi, Asad Ali, Najeeha Talat Iqbal
      Pages: 63 - 67
      Abstract: Furqan Kabir, Marvi Tariq, Fatima Aziz, Syed Imran Rizvi, Shahida Qureshi, Asad Ali, Najeeha Talat Iqbal
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):63-67
      Background: Viral flu is the predominant cause of hospitalization in young children, which invariably leads to enhanced morbidity and mortality in children in developing countries. Initial treatment of viral flu is based on presumptive diagnosis. Bedside testing is not common in clinical settings because of variable sensitivity and specificity of rapid tests in different settings. Methods: To address this issue, we evaluated the performance of Binax influenza A/B rapid testing kit against two robust molecular platforms (quantitative real-time polymerase chain reaction [qRT-PCR] and TaqMan array card [TAC]) in 24 nasopharyngeal (NP) swabs, collected from children under 5 years of age. Results: Binax was found to be less sensitive (56%), but 100% specific compared to qRT-PCR (100%) and TAC (>100%). Using TAC cards, 75% of samples were found to be coinfected with other bacterial and viral targets. Conclusion: Binax flu is suitable for bedside testing in clinical and community settings. The negative results of Binax should be interpreted with caution and confirmed by rapid molecular tests.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):63-67
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_107_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Preparation of chitosan-coated Fe3O4 nanoparticles and assessment of their
           effects on enzymatic antioxidant system as well as high-density
           lipoprotein/low-density lipoprotein lipoproteins on wistar rat

    • Authors: Bahare Khedri, Kahin Shahanipour, Soheil Fatahian, Fariba Jafary
      Pages: 68 - 73
      Abstract: Bahare Khedri, Kahin Shahanipour, Soheil Fatahian, Fariba Jafary
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):68-73
      Background: Recently, the nanoparticle (NP) application in many fields of medicine due to their specific physical and chemical properties has been developed. Therefore, especially in vivo evaluation of their toxicity is necessary. The aim of this study was to compare the toxicity of Fe3O4NPs coated with biocompatible compounds and uncoated NPs. Methods: Wetted chemical method (or wet chemical method) was used to synthesize Fe3O4NPs. The synthesized NPs were coated with chitosan and the coating interactions were investigated by Fourier-transform infrared spectroscopy. The magnetic and structural properties of Fe3O4and coated Fe3O4NPs were evaluated by transmission electron microscope and X-ray diffraction. The toxicity assessment of Fe3O4and coated Fe3O4NPs was studied in mice by intraperitoneal injections during the 1-month period. Antioxidant enzyme glutathione peroxidase (GPX), malondialdehyde, and low-density lipoprotein/high-density lipoprotein were measured 15 and 30 days after injection. Results: The synthesized NPs have a single phase and spinal structure and their size distribution in the net form is 5–10 nm. Some factors were changed due to the injection of both uncoated and coated NPs. The all-used concentration of chitosan-coated Fe3O4NPs could increase the GPX enzyme activity. The Fe3O4NPs can reduce the GPX enzyme activity in high concentration (50 mg/kg, 100 mg/kg, and 150 mg/kg). Conclusion: The results indicated that NPs based on their dosage and body condition can induce toxicity effects in the body. It should be mentioned that the chitosan-coated ones can decrease their effects.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):68-73
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_98_17
      Issue No: Vol. 2, No. 1 (2018)
       
  • Genetic polymorphism of rare mutations in Mycobacterium
           tuberculosis-infected patients in Delhi

    • Authors: Himanshu Vashistha, Mahmud Hanif, Kamal Kishore Chopra, Divya Shrivastava, Ashwani Khanna
      Pages: 74 - 81
      Abstract: Himanshu Vashistha, Mahmud Hanif, Kamal Kishore Chopra, Divya Shrivastava, Ashwani Khanna
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):74-81
      Background: There is a wide variation in existing Mycobacterium tuberculosis strains across the globe, and false results in line probe assay (LPA) can occur due to the presence of unique genetic mutations in different settings. Objectives: An attempt was made to observe uncommon mutations in multidrug-resistant tuberculosis (MDR-TB) strains and determination of genetic diversity by spoligotyping and to study the treatment outcome in patients with uncommon mutations. Materials and Methods: Band pattern analysis of LPA strips was performed as per manufacturer's instructions. DNA sequencing was performed to confirm the presence of uncommon mutations in Intermediate Reference Laboratory in Delhi state. Results: Four uncommon mutations were recognized along with 12 unique spoligotype patterns which serve as an update to worldwide databases. The noteworthy presence of a spoligotype previously rarely seen in India was the SIT53/T1 pattern. Central Asian (CAS) spoligotype was highly associated with MDR followed by Beijing type. During follow-up, the treatment outcomes of cases showing uncommon mutations were considered as cured, after completion of their treatment. Conclusion: The rifampicin resistance appears to be an effective marker of MDR-TB. The presence of uncommon mutations confirms genetic polymorphism that may require treatment targeted at both drug-resistant and drug-susceptible phenotypes for the better management of patients with MDR-TB.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):74-81
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_13_18
      Issue No: Vol. 2, No. 1 (2018)
       
  • Pacemaker site infection caused by Rapidly Growing Nontuberculous
           Mycobacteria (RGM)

    • Authors: Jhansi Vani Devana, Narasimhan Calambur, B Ravinder Reddy
      Pages: 82 - 84
      Abstract: Jhansi Vani Devana, Narasimhan Calambur, B Ravinder Reddy
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):82-84
      There has been an increased use of cardiac pacemaker device utilization in cardiac patients with a corresponding increase of device-related infections in these patients. The common cause of postpacemaker implantation infection is either Gram-positive or Gram-negative bacteria. Infection of pacemaker implantation site due to nontuberculous mycobacteria is rare. Globally, thirty-two cases of pacemaker device infections caused by nontuberculous mycobacteria were reported. It is important to carry out not only species identification of mycobacteria but also drug susceptibility testing to start precise treatment to those patients, who are infected with atypical mycobacteria. We report a patient with pacemaker pocket infection due to Mycobacterium chelonae.
      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):82-84
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_6_18
      Issue No: Vol. 2, No. 1 (2018)
       
  • Commentary on “Maes R. Tuberculosis serology is useful in rural
           areas: BBRJ 2017;1(2):85-93”

    • Authors: Bhaskar C Harinath, Lingaraja Jena
      Pages: 85 - 86
      Abstract: Bhaskar C Harinath, Lingaraja Jena
      Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):85-86

      Citation: Biomedical and Biotechnology Research Journal (BBRJ) 2018 2(1):85-86
      PubDate: Mon,5 Mar 2018
      DOI: 10.4103/bbrj.bbrj_100_17
      Issue No: Vol. 2, No. 1 (2018)
       
 
 
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