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Publisher: Medknow Publishers   (Total: 429 journals)

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Showing 1 - 200 of 429 Journals sorted alphabetically
Acta Medica Intl.     Open Access   (SJR: 0.101, CiteScore: 0)
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advanced Biomedical Research     Open Access  
Advances in Human Biology     Open Access   (Followers: 3)
Advances in Skeletal Muscle Function Assessment     Open Access  
African J. for Infertility and Assisted Conception     Open Access  
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.25, CiteScore: 1)
African J. of Trauma     Open Access   (Followers: 1)
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Alexandria J. of Pediatrics     Open Access  
Ancient Science of Life     Open Access   (Followers: 5)
Anesthesia : Essays and Researches     Open Access   (Followers: 10)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.258, CiteScore: 1)
Annals of Bioanthropology     Open Access   (Followers: 4)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.308, CiteScore: 1)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery     Open Access  
Annals of Indian Psychiatry     Open Access  
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 8, SJR: 0.352, CiteScore: 1)
Annals of Saudi Medicine     Open Access   (SJR: 0.238, CiteScore: 1)
Annals of Thoracic Medicine     Open Access   (Followers: 6, SJR: 0.524, CiteScore: 1)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 13, SJR: 0.152, CiteScore: 0)
Annals of Tropical Pathology     Open Access  
Apollo Medicine     Open Access  
APOS Trends in Orthodontics     Open Access  
Arab J. of Interventional Radiology     Open Access  
Archives of Cardiovascular Imaging     Open Access   (Followers: 1, SJR: 0.187, CiteScore: 0)
Archives of Intl. Surgery     Open Access   (Followers: 10, SJR: 0.302, CiteScore: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Medicine and Surgery     Open Access  
Archives of Pharmacy Practice     Open Access   (Followers: 6, SJR: 0.102, CiteScore: 0)
Archives of Trauma Research     Open Access   (Followers: 3, SJR: 0.37, CiteScore: 2)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 4)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.856, CiteScore: 2)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.35, CiteScore: 1)
Asian Pacific J. of Reproduction     Open Access   (SJR: 0.227, CiteScore: 1)
Asian Pacific J. of Tropical Biomedicine     Open Access   (Followers: 2, SJR: 0.491, CiteScore: 2)
Asian Pacific J. of Tropical Medicine     Open Access   (Followers: 1, SJR: 0.561, CiteScore: 2)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
Biomedical and Biotechnology Research J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Canadian J. of Rural Medicine     Full-text available via subscription   (SJR: 0.202, CiteScore: 0)
Cancer Translational Medicine     Open Access   (Followers: 2)
Cardiology Plus     Open Access  
Chinese Medical J.     Open Access   (Followers: 10, SJR: 0.52, CiteScore: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Cancer Investigation J.     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 2)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 10, SJR: 0.811, CiteScore: 2)
Contemporary Clinical Dentistry     Open Access   (Followers: 4, SJR: 0.353, CiteScore: 1)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.543, CiteScore: 1)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.152, CiteScore: 0)
Dental Research J.     Open Access   (Followers: 11, SJR: 0.416, CiteScore: 1)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 6, SJR: 0.242, CiteScore: 0)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1, SJR: 1.799, CiteScore: 2)
Egyptian J. of Chest Diseases and Tuberculosis     Open Access   (Followers: 3, SJR: 0.155, CiteScore: 0)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.127, CiteScore: 0)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Nursing J.     Open Access  
Egyptian Orthopaedic J.     Open Access   (Followers: 2)
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.822, CiteScore: 2)
Environmental Disease     Open Access   (Followers: 3)
Eurasian J. of Pulmonology     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.749, CiteScore: 2)
European J. of General Dentistry     Open Access   (Followers: 1, SJR: 0.12, CiteScore: 0)
European J. of Prosthodontics     Open Access   (Followers: 3)
European J. of Psychology and Educational Studies     Open Access   (Followers: 11, SJR: 0.113, CiteScore: 0)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.112, CiteScore: 0)
Genome Integrity     Open Access   (Followers: 3, SJR: 0.153, CiteScore: 0)
Glioma     Open Access  
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Gynecology and Minimally Invasive Therapy     Open Access   (SJR: 0.311, CiteScore: 1)
Hamdan Medical J.     Open Access  
Heart and Mind     Open Access  
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
Ibnosina J. of Medicine and Biomedical Sciences     Open Access  
IJS Short Reports     Open Access  
Imam J. of Applied Sciences     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.478, CiteScore: 1)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (Followers: 1, SJR: 0.361, CiteScore: 1)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.37, CiteScore: 1)
Indian J. of Critical Care Medicine     Open Access   (Followers: 3, SJR: 0.604, CiteScore: 1)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.266, CiteScore: 1)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.468, CiteScore: 1)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 5, SJR: 0.445, CiteScore: 1)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1, SJR: 0.791, CiteScore: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4, SJR: 0.568, CiteScore: 1)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.425, CiteScore: 1)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.503, CiteScore: 1)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.656, CiteScore: 1)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.102, CiteScore: 0)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.347, CiteScore: 1)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.23, CiteScore: 0)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 3, SJR: 0.225, CiteScore: 1)
Indian J. of Ophthalmology     Open Access   (Followers: 4, SJR: 0.498, CiteScore: 1)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 8, SJR: 0.392, CiteScore: 1)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.199, CiteScore: 0)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.454, CiteScore: 1)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 2, SJR: 0.276, CiteScore: 1)
Indian J. of Pharmacology     Open Access   (SJR: 0.412, CiteScore: 1)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.311, CiteScore: 0)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.408, CiteScore: 1)
Indian J. of Psychological Medicine     Open Access   (SJR: 0.368, CiteScore: 1)
Indian J. of Public Health     Open Access   (Followers: 1)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Respiratory Care     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.119, CiteScore: 0)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.34, CiteScore: 0)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Transplantation     Open Access  
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Indian Spine J.     Open Access  
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intervention     Open Access   (Followers: 1)
Intl. Archives of Health Sciences     Open Access  
Intl. J. of Abdominal Wall and Hernia Surgery     Open Access   (Followers: 1)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Clinicopathological Correlation     Open Access  
Intl. J. of Community Dentistry     Open Access  
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1, SJR: 0.192, CiteScore: 0)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 3, SJR: 0.142, CiteScore: 0)
Intl. J. of Growth Factors and Stem Cells in Dentistry     Open Access  
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 6)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.535, CiteScore: 1)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4, SJR: 0.17, CiteScore: 0)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 2)
Intl. J. of Orofacial Biology     Open Access   (Followers: 1)
Intl. J. of Orofacial Research     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.623, CiteScore: 1)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 5, SJR: 0.653, CiteScore: 1)
Intl. J. of the Cardiovascular Academy     Open Access   (SJR: 0.105, CiteScore: 0)
Intl. J. of Trichology     Open Access   (SJR: 0.4, CiteScore: 1)
Intl. J. of Yoga     Open Access   (Followers: 14)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 5)

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Journal Cover
Advanced Biomedical Research
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2277-9175
Published by Medknow Publishers Homepage  [429 journals]
  • Nocardia Isolation of Soil

    • Authors: Mehdi Fatahi Bafghi, Seyyed Saeed Eshraghi
      Pages: 1 - 1
      Abstract: Mehdi Fatahi Bafghi, Seyyed Saeed Eshraghi
      Advanced Biomedical Research 2017 6(1):1-1

      Citation: Advanced Biomedical Research 2017 6(1):1-1
      PubDate: Tue,31 Jan 2017
      DOI: 10.4103/2277-9175.199262
      Issue No: Vol. 6, No. 1 (2017)
       
  • Wound Healing Effect of Arnebia euchroma gel on Excisional Wounds in Rats

    • Authors: Maryam Mohsenikia, Shahrzad Khakpour, Zahra Azizian, Soheil Ashkani-Esfahani, Seyyede Tahereh Razavipour, Pooya Toghiani
      Pages: 2 - 2
      Abstract: Maryam Mohsenikia, Shahrzad Khakpour, Zahra Azizian, Soheil Ashkani-Esfahani, Seyyede Tahereh Razavipour, Pooya Toghiani
      Advanced Biomedical Research 2017 6(1):2-2
      Background: Wound healing is a complex process leading to regeneration of damaged skin tissue. Arnebia euchroma (AE) have many effective activities such as anti-inflammatory, antimicrobial, antioxidative, and anti-tumoral effects. The extract of AE has positive effects on burn wounds. This study is designed to investigate the healing effects of AE on excisional wounds in rats. Materials and Methods: Thirty six rats with the age of 8 weeks divided into three groups. One group (E1) was treated with AE gel at a concentration of 10%. Control group (C1) received normal saline and the vehicle group (C2) was treated with carboxymethyl cellulose gel as the vehicle for 14 days. Stereological analysis was done to investigate the collagen bundle and hair follicale synthesis, vascularization, fibroblast proliferation. Pathological evaluation was also conducted. Results: In this study, pathological evaluation showed severe acute inflammation in C2 group, chronic and acute inflammation in C1 and also more wound contraction in E1 in comparison with other groups. There was a meaningful difference between E1 and C1 regarding fibroblast proliferation (P < 0.05). Conclusion: Results of this study revealed the healing effect of AE on excisional wounds and recommend its administration after further clinical investigations.
      Citation: Advanced Biomedical Research 2017 6(1):2-2
      PubDate: Tue,31 Jan 2017
      DOI: 10.4103/2277-9175.199260
      Issue No: Vol. 6, No. 1 (2017)
       
  • Psychological and Familial Factors of Depression in Relation to Adolescent
           Smoking Behavior

    • Authors: Hamidreza Roohafza, Razieh Omidi, Tahereh Alinia, Kamal Heidari, Marziyeh Farshad, Hossein Davari, Zahra Abtin, Ezat Shahriari, Mahshid Taslimi, Masoumeh Sadeghi
      Pages: 3 - 3
      Abstract: Hamidreza Roohafza, Razieh Omidi, Tahereh Alinia, Kamal Heidari, Marziyeh Farshad, Hossein Davari, Zahra Abtin, Ezat Shahriari, Mahshid Taslimi, Masoumeh Sadeghi
      Advanced Biomedical Research 2017 6(1):3-3
      Background: Several common factors have been identified for smoking and depression. The The present study explores the relation of psychological and familial factors with depression, by student smoking behavior. Materials and Methods: A total of 5500 middle- and high-school students were selected in Isfahan province in 2010. A self-administered questionnaire collected data on background characteristics, smoking status, depression, and risk factors. Univariate analysis multiple logistic regressions were conducted to compare between depressed and nondepressed people by adolescent smoking status. Odds ratios and the corresponding 95% confidence intervals (CIs) were reported. Results: Fathers lower education attainment was accompanied adolescents higher depression prevalence. Parental smoking and sibling smoking increased the depression likelihood by 1.41 (95% CI: 1.18, 1.68) and 1.43 folds (95% CI: 1.04–1.94) for never-smokers. Positive attitude toward smoking increased the probability of depression by 1.18 among never-smokers. Never-smokers lacking refusal skill had 1.23 (1.03–1.47) higher chance of depression. A higher level of self-efficacy related to lower chance of depression. Taking risky behavior, increased the depression likelihood by 1.56 (95% CI: 1.29–1.89) in never-smokers, by 1.85 (95% CI: 1.37–2.44) in experimental smokers, and by 1.14 times (95% CI: 1.01–1.72) in current smokers. Family conflict increased depression chance by 2.25 times (95% CI: 1.89–2.66) in never-smokers, by 1.95 (95% CI: 1.46–2.61) in experimental smokers, and by 2.06 times (95% CI: 1.38–3.08) in current smokers. Conclusions: Targeting self-efficacy level, risky behavior, and family conflict can drop the comorbidity of smoking and depression simultaneously. This may help public health practitioners and policymakers to develop common strategies in reducing adolescents smoking and depression comorbidity.
      Citation: Advanced Biomedical Research 2017 6(1):3-3
      PubDate: Tue,31 Jan 2017
      DOI: 10.4103/2277-9175.199261
      Issue No: Vol. 6, No. 1 (2017)
       
  • Effects of the Schema Therapy and Mindfulness on the Maladaptive Schemas
           Hold by the Psoriasis Patients with the Psychopathology Symptoms

    • Authors: Parvin Jamali Gojani, Mohsen Masjedi, Shahnaz Khaleghipour, Ehsan Behzadi
      Pages: 4 - 4
      Abstract: Parvin Jamali Gojani, Mohsen Masjedi, Shahnaz Khaleghipour, Ehsan Behzadi
      Advanced Biomedical Research 2017 6(1):4-4
      Background: This study aimed to compare the effects of the schema along with mindfulness-based therapies in the psoriasis patients. Materials and Methods: This semi-experimental study with post- and pre-tests was conducted on the psoriasis patients in the Dermatology Clinic of the Isfahan Alzahra Hospital, Iran using the convenience sampling in 2014. The patients had a low general health score. The experimental groups included two treatment groups of schema-based (n = 8) and mindfulness (n = 8). Both groups received eight 90-min sessions therapy once a week; they were compared with 8 patients in the control group. To evaluate the psoriasis patients' maladaptive schema, Young schema questionnaire was used. Data were analyzed through the covariance analysis test. Results: There was a significant difference between the schema-based therapy and mindfulness groups with the control group. There was also a significant difference between the schema-based therapy groups consisting of the defeated schema, dependence/incompetence schema, devotion schema, stubbornly criteria schema, merit schema, restraint/inadequate self-discipline schema, and the control group. Moreover, a significant difference existed between the maladaptive schema of mindfulness therapy group and the controls. There was a significant difference concerning the improvement of the psychopathologic symptoms between the mindfulness therapy group and the control group. Conclusions: This study showed similar effects of both the schema and mindfulness-based therapies on the maladaptive schemas in improving the psoriasis patients with the psychopathologic symptoms.
      Citation: Advanced Biomedical Research 2017 6(1):4-4
      PubDate: Tue,31 Jan 2017
      DOI: 10.4103/2277-9175.190988
      Issue No: Vol. 6, No. 1 (2017)
       
  • Comparing the Effect of Dressing Versus No-dressing on Exit Site Infection
           and Peritonitis in Chronic Ambulatory Peritoneal Dialysis Patients

    • Authors: Shahram Taheri, Mahdieh Ahmadnia, Mojgan Mortazavi, Shirin Karimi, Homa Reihani, Shiva Seirafian
      Pages: 5 - 5
      Abstract: Shahram Taheri, Mahdieh Ahmadnia, Mojgan Mortazavi, Shirin Karimi, Homa Reihani, Shiva Seirafian
      Advanced Biomedical Research 2017 6(1):5-5
      Bachground: Peritonitis and exit site (ES) infection are two main complications of peritoneal dialysis. There are some controversies regard to preventive strategies for ES care. In this study we compared peritonitis and ES infection rates in patients with and without dressing. Materials and Methods: This historical cohort study carried out on 72 patients under continuous ambulatory peritoneal dialysis treatment, 54 with dressing versus 18 patients without dressing, followed from October 1, 2010 to March 31, 2011 for peritonitis and ES infection. Results: A total of 17 episodes of ES infection occurred in 12 patients in dressing group, but no case was seen in no-dressing group (P = 0.02). Twenty-one episodes of peritonitis occurred in 15 patients in both groups (one episode every 20.6 patient-months). In no-dressing group two episodes occurred in only one patient (one episode every 54 patient-months), and in dressing group, 19 episode in 14 patients (one episode every 17.1 patient-months) (P = 0.03). Peritonitis was significantly more frequent in male versus female in overall patients (38% vs. 14%, P = 0.025) and in dressing group (52% vs. 15%, P = 0.003). In dressing group, peritonitis was more frequent in diabetics versus non-diabetics (48% vs. 11%, P = 0.01). Odds ratio for developing peritonitis was 9.4 in dressing group (95% confidence interval [CI] =1.05 − 84.4; P = 0.045), and 4.4 in men (95% CI = 1.26 − 15.19; P = 0.02). Conclusion: In this study, chronic ES care without dressing was associated with lower risk of peritonitis and ES infection.
      Citation: Advanced Biomedical Research 2017 6(1):5-5
      PubDate: Tue,31 Jan 2017
      DOI: 10.4103/2277-9175.199263
      Issue No: Vol. 6, No. 1 (2017)
       
  • Differential Immune Reactivity Pattern of SW48 and SW1116 Colorectal
           Cancer Cell Lines with Colorectal Cancer Patients Sera

    • Authors: Ghasem Ghalamfarsa, Seyyed Vahid Hosseini, Maryam Hamidinia, Abbas Ghaderi, Mahmoud Mahmoudi, Zahra Mojtahedi
      Pages: 6 - 6
      Abstract: Ghasem Ghalamfarsa, Seyyed Vahid Hosseini, Maryam Hamidinia, Abbas Ghaderi, Mahmoud Mahmoudi, Zahra Mojtahedi
      Advanced Biomedical Research 2017 6(1):6-6
      Background: Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide. It is also known as the second leading cause of deaths as the early stage detection is not yet available by current methods. So identification of biomarkers can also be functional in early diagnosis and prognosis. Materials and Methods: We examined sera from 60 CRC patients of different stages as a source of auto-antibody as well as two human CRC cell lines with different invasive capacities (SW48 and SW1116) as the source of antigens. The pattern of immune reactivity in immuneblotting tests between mentioned cell lines and CRC patients' sera were evaluated by ImageJ software. Results: The Immune reactivity pattern of two cell lines (SW48 and SW1116) with CRC patients' sera were different in band intensities and the most immune reactivity intensity was observed in SW48 cell lysate with sera from Stage III CRC patients. Conclusion: Due to the humoral immune response, sera from Stage III CRC patients contained autoantibodies that demonstrated higher immune reactivity. Moreover, SW48 cell line with high aggressive behavior reacted to CRC patients' sera with greater intensity compared with less aggressive behavior cell line (SW1116). Therefore, it is required to use other techniques such as two-dimensional electrophoresis and mass spectrometry.
      Citation: Advanced Biomedical Research 2017 6(1):6-6
      PubDate: Tue,31 Jan 2017
      DOI: 10.4103/2277-9175.199264
      Issue No: Vol. 6, No. 1 (2017)
       
  • Is there any Correlation between Magnetic Resonance Imaging Features of
           Breast Lesions of BIRADS Category 4 with Histopathologic Results?

    • Authors: Maryam Farghadani, Ghazale Jamalipoor Soofi, Amir Hossein Sarrami
      Pages: 7 - 7
      Abstract: Maryam Farghadani, Ghazale Jamalipoor Soofi, Amir Hossein Sarrami
      Advanced Biomedical Research 2017 6(1):7-7
      Background: To evaluate the correlation of magnetic resonance imaging (MRI) features of breast lesions of Breast Imaging Reporting and Database System (BI-RADS) category 4 with histopathologic results. Materials and Methods: In a prospective study between December 2013 and April 2015, patients with suspicious mammographic and/or ultrasound findings referred for Breast MRI were evaluated. Patients with lesions of BI-RADS category 4 were enrolled with a written informed consent. In each patient, mass lesion (ML) or nonmass lesion (NML) was determined, and different characteristics of the lesions were recorded. A follow-up program was taken with mean 3–12 months. Patients who underwent core needle biopsy or open biopsy were summoned. Results: Seventy-eight females aged 24–67 years (mean 43.1 ± 8.8) met the inclusion criteria and had adequate samples for histopathologic study. Twenty-nine (37.2%) patients had ML and 49 (62.8%) patients had NML. Tissue sampling in 63 (80.7%) patients was through core needle biopsy and in 15 (19.2%) patients through surgery. A wide spectrum of benign and malignant pathologic diagnoses was seen. In statistical analysis, none of the MRI features has a significant correlation with any specific histopathologic diagnosis (P = 0.185). However, the relation between the MRI category (ML or NML) and pathology results was significant at level of 0.1 (P = 0.06). Conclusion: This study showed that a wide spectrum of histopathologic results is seen in BI-RADS category 4. However, in this sample volume, none of the MRI features in this BI-RADS category has a significant correlation with any specific histopathologic diagnosis.
      Citation: Advanced Biomedical Research 2017 6(1):7-7
      PubDate: Tue,31 Jan 2017
      DOI: 10.4103/2277-9175.199258
      Issue No: Vol. 6, No. 1 (2017)
       
  • Corticosteroid and Azithromycin in Idiopathic Granulomatous Mastitis

    • Authors: Marzieh Salehi, Maryam Salehi, Nader Kalbasi, Atousa Hakamifard, Hassan Salehi, Mohammad Mahdi Salehi, Jalil Sharifian
      Pages: 8 - 8
      Abstract: Marzieh Salehi, Maryam Salehi, Nader Kalbasi, Atousa Hakamifard, Hassan Salehi, Mohammad Mahdi Salehi, Jalil Sharifian
      Advanced Biomedical Research 2017 6(1):8-8
      Background: Mastitis is an inflammatory disorder in breast tissues due to bacterial factors, mycobacterial infections or autoimmune diseases. Idiopathic granulomatous mastitis (IGM) is a form of mastitis which may be affected by systematic diseases such as sarcoidosis, and infectious causes such as mycobacterium and fungus. This study evaluates the efficacy of medical therapy with a combination of corticosteroid and Azithromycin in patients with IGM. Materials and Methods: This study is a clinical trial research carried out in Alzahra Hospital (Isfahan, Iran) in 2013 on granulomatous mastitis patients. It was administered 250 mg of Azithromycin per 12 hour and 60 mg of Prednisolone per day within 2 weeks. Next, they took 40 mg/day within 8 weeks, and this dosage was tapered during 6 months and the patients clinically and radiologically followed up. The studied patients were examined within 1 week, 2 weeks, 1 month, 3 months, and 6 months, from the beginning of treatment. Results: This study investigated granulomatous mastitis patients in Alzahra hospital in 2013. The mean age of these patients was 33.6 ± 8.9, and their age range was 18–56 years old. Among 26 studied patients, 24 persons (92.3%) according to follow-up the patients by physical examination and sonography responded to treatment of corticosteroid and Azithromycin. The remaining (7.7%) underwent surgery. Treatment periods in case of drug use were respectively, 8.5 ± 0.71 months. Conclusion: Treatment with corticosteroid and Azithromycin is an effective and appropriate treatment for IGM.
      Citation: Advanced Biomedical Research 2017 6(1):8-8
      PubDate: Tue,31 Jan 2017
      DOI: 10.4103/2277-9175.199259
      Issue No: Vol. 6, No. 1 (2017)
       
  • Solution of Azelaic Acid (20%), Resorcinol (10%) and Phytic Acid (6%)
           Versus Glycolic Acid (50%) Peeling Agent in the Treatment of Female
           Patients with Facial Melasma

    • Authors: Gita Faghihi, Azam Taheri, Zabihollah Shahmoradi, Mohammad Ali Nilforoushzadeh
      Pages: 9 - 9
      Abstract: Gita Faghihi, Azam Taheri, Zabihollah Shahmoradi, Mohammad Ali Nilforoushzadeh
      Advanced Biomedical Research 2017 6(1):9-9
      Background: Melasma, a common acquired disorder of hyperpigmentation, especially in women, is often resistant to therapy. This study was aimed to evaluate the efficacy and safety of azelaic acid, resorcinol and phytic acid solution in chemical peeling of melasma in comparison to 50% glycolic acid. Materials and Methods: This clinical trial was performed, on 42 female patients with bilateral melasma. Severity of melasma was assessed by melasma area and severity index (MASI). Combination of (20% azelaic acid + 10% resorcinol + 6% phytic acid) was used as a new peeling agent on the right side of the face and 50% glycolic acid on the left side every 2 weeks for 6 times. Follow-up was carried out for 3 months after the last session. Any decrease in MASI score and unwanted complications following peeling were evaluated and compared during the trial. Results: Patients showed marked improvement as calculated with MASI score before and after treatment in both sides of the face. The efficacy of combination formula (azelaic acid, resorcinol and phytic acid) was similar to glycolic acid, but with fewer complications. There was no statistically difference in improvement between two groups (P > 0.05). However, the patient's discomfort following procedures was significantly lower with azelaic acid, resorcinol and phytic compared with the glycolic acid peels (P < 0.05) and there was the same duration in the beginning of the therapeutic response in both groups. Conclusion: Results showed that triple-combination was found to be an effective and safe peeling agent in the treatment of melasma and it was as effective as 50% glycolic acid peel.
      Citation: Advanced Biomedical Research 2017 6(1):9-9
      PubDate: Wed,22 Feb 2017
      DOI: 10.4103/2277-9175.200784
      Issue No: Vol. 6, No. 1 (2017)
       
  • Cornea Collagen Cross-linking for Keratoconus: A Comparison between
           Accelerated and Conventional Methods

    • Authors: Hasan Razmjoo, Alireza Peyman, Ali Rahimi, Hoda Jafari Modrek
      Pages: 10 - 10
      Abstract: Hasan Razmjoo, Alireza Peyman, Ali Rahimi, Hoda Jafari Modrek
      Advanced Biomedical Research 2017 6(1):10-10
      Background: Keratoconus is a progressive degenerative disorder of the cornea in which structural changes in the cornea cause it to become thin and conical in shape. Recently, collagen cross-linking (CXL) has been introduced as an effective intervention in management of progressive keratoconus. Accelerated CXL is a new protocol of this procedure which reduces corneal ultraviolet irradiation exposure time to 5 min. This study aimed to compare visual acuity, keratometry and topographic criteria of keratoconic eyes after conventional and accelerated CXL with a six-month follow-up. Materials and Methods: In this prospective interventional study we assessed eyes of 40 patients. Patients were divided into two groups randomly. One group underwent accelerated (5 min) CXL and the other underwent conventional (30 min) CXL. Visual acuity, topographic criteria and keratometry were assessed preoperatively and 6 months postoperatively. Results: In the present study we assessed 40 patients, 50% of which were right eye (OD) and 50% were left eye (OS). Mean age of patients in the accelerated group was 22.10 and in the conventional group was 22.80 years. Our results showed no significant differences between visual acuity, keratometric and topographic criteria in the two groups before intervention. Likewise our results manifested no significant difference between visual acuity, keratometric, refractive and topographic criteria after intervention. Conclusion: According to our survey topographic criteria and keratometry improvement in the accelerated and conventional protocol are the same. So accelerated protocol is suggested as a safe and effective option for management of progressive keratoconus.
      Citation: Advanced Biomedical Research 2017 6(1):10-10
      PubDate: Wed,22 Feb 2017
      DOI: 10.4103/2277-9175.200785
      Issue No: Vol. 6, No. 1 (2017)
       
  • The Efficacy of Augment of D-Cycloserine and Cognitive-behavioral Therapy
           on Adolescent with one Type of Anxiety Disorders: A Double-blind
           Randomized Controlled Trial

    • Authors: Soroor Arman, Ali Soheilimehr, Mohammad Reza Maracy
      Pages: 11 - 11
      Abstract: Soroor Arman, Ali Soheilimehr, Mohammad Reza Maracy
      Advanced Biomedical Research 2017 6(1):11-11
      Background: This study was designed to investigating the effect of combining D-cycloserine (DCS) and cognitive-behavioral therapy (CBT) on adolescent with at least one type of anxiety disorders. Materials and Methods: The present study was conducted as a double-blind randomized controlled trial on 36 adolescent with anxiety disorders. Patients were assessed in two groups. In addition to 4 sessions of weekly CBT in both groups; case group, received a 50-mg DCS capsules, control group, received Placebo daily for a month. Patients received DCS capsules or placebo 1 h before sessions of CBT. Age, sex, kind of anxiety disorders “screen for child anxiety related disorders (SCARED)” and “cognitive abilities test (CATS)” scores were evaluated and compared between groups. Results: The mean age of the studied patients (29 females (80.6%) and 7 males (19.4%)) was 14.1 ± 1.8 years. The most frequent anxiety disorder among the study population was generalized social disorder (GAD) (77.7%). Age, sex and the frequency of anxiety disorders were not statistically significant between the study groups (P > 0.05). The mean score of “SCARED” and “CATS” at before starting the treatment, after treatment and three month after the treatment were not statistically significant between groups (P > 0.05). Also, decrease in values of “SCARED” and “CATS” during the evaluation time periods was not statistically significant between groups (P > 0.05). Conclusions: Findings of this study showed that there has been no difference in symptoms improvement in adolescent with anxiety disorder who received treatment protocol including 4 sessions of CBT, weekly, together with 50 mgs of DCS compared to the patients of the control group.
      Citation: Advanced Biomedical Research 2017 6(1):11-11
      PubDate: Wed,22 Feb 2017
      DOI: 10.4103/2277-9175.200786
      Issue No: Vol. 6, No. 1 (2017)
       
  • Effects of Phlebotomy on Liver Enzymes and Histology of Patients with
           Nonalcoholic Fatty Liver Disease

    • Authors: Mahsa Khodadoostan, Maryam Zamanidoost, Ahmad Shavakhi, Hosein Sanei, Masood Shahbazi, Mehdi Ahmadian
      Pages: 12 - 12
      Abstract: Mahsa Khodadoostan, Maryam Zamanidoost, Ahmad Shavakhi, Hosein Sanei, Masood Shahbazi, Mehdi Ahmadian
      Advanced Biomedical Research 2017 6(1):12-12
      Background: Nonalcoholic fatty liver disease (NAFLD), defined as excessive liver fat deposition and one of end-stage liver disease causes. Increased ferritin levels are associated with insulin resistance and a higher hepatic iron and fat content. Hyperferritinemia has been associated with severity of liver damage in NAFLD. The study aimed to evaluate the effects of phlebotomy on liver enzymes and histology in such patients. Materials and Methods: Thirty-two eligible patients who had NAFLD and after 6 months of lifestyle modification still had NAFLD, and whose ferritin serum was above 250 mg/dl, were enrolled in this clinical trial study. After written informed consent was obtained, each patient's blood serum was taken for aspartate transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALK-P), complete blood count (CBC), total iron-binding capacity (TIBC), iron, and ferritin. Then the patients underwent liver biopsy. After that patients underwent phlebotomy, giving 350 cc blood monthly. Before every phlebotomy, hemoglobin and ferritin were checked. If they were in the goal range, phlebotomy was discontinued and the patient underwent liver biopsy. A serum sample was taken for testing at the beginning of the study. The results before and after phlebotomy were compared. The maximum duration of the study was 6 months. Results: Thirty-two patients (26 males and 6 females) were enrolled, and the mean average age was 33.7 ± 6.74 years. Phlebotomy improved liver enzymes and histology of liver significantly (P < 0.001) and induced reduction of ferritin. Conclusion: Phlebotomy is effective for the improvement of liver enzymes and histology in patients with NAFLD and hyperferritinemia.
      Citation: Advanced Biomedical Research 2017 6(1):12-12
      PubDate: Wed,22 Feb 2017
      DOI: 10.4103/2277-9175.200787
      Issue No: Vol. 6, No. 1 (2017)
       
  • The role of Inflammatory Processes in Occurrence of Left Ventricular
           Failure in Patients with Chronic Kidney Disease

    • Authors: Hassan Shemirani, Sara Tavakol, Abdolamir Atapoor, Jafar Golshahi
      Pages: 13 - 13
      Abstract: Hassan Shemirani, Sara Tavakol, Abdolamir Atapoor, Jafar Golshahi
      Advanced Biomedical Research 2017 6(1):13-13
      Background: Recently, the relationship between increased level of inflammatory mediators and occurrence of left ventricular failure in patients with kidney disease has been suggested. The present study attempted to assess relationship between inflammatory mediators and occurrence of left ventricular failure in patients with chronic kidney disease. Materials and Methods: This cross-sectional study was performed at Noor and Hazrat Aliasghar hospital in Isfahan between September 2012 to September 2013 on patients aged >19 years that referred for following their chronic kidney disease. Serum level of inflammatory parameters including C-reactive protein (CRP) and Interleukin-6 (IL-6) was measured using spectrophotometer. All patients were also assessed using M-mode echocardiography to determine left ventricular ejection fraction (LVEF). Results: The group with significant reduced LVEF showed lower GFR when compared to the normal LVEF group (40.73 ± 20.61% versus 44.43 ± 17.98%, P = 0.032). Comparing GFR across the three groups with normal LVEF >55%), with mild LV dysfunction (LVEF: 45 – 55) those with significant LV dysfunction (LVEF < 45%) showed significantly lower GFR level in latter group compared with normal LVEF and mild LV dysfunction group (P = 0.026). Although the level of serum CRP was significantly higher in patients with significant left ventricular failure than other groups (P = 0.018). Conclusion: Inflammatory processes can potentially affect left ventricular function in patients with chronic kidney disease. In this regard, increased level of CRP may be a main factor for predicting severity of left ventricular failure in these patients.
      Citation: Advanced Biomedical Research 2017 6(1):13-13
      PubDate: Wed,22 Feb 2017
      DOI: 10.4103/2277-9175.200788
      Issue No: Vol. 6, No. 1 (2017)
       
  • Expression of Estrogen Receptor Alpha in Malignant Melanoma

    • Authors: Parvin Rajabi, Marzieh Bagheri, Mohsen Hani
      Pages: 14 - 14
      Abstract: Parvin Rajabi, Marzieh Bagheri, Mohsen Hani
      Advanced Biomedical Research 2017 6(1):14-14
      Background: Features of malignant melanoma (MM) vary in the different geographic regions of the world. This may be attributable to environmental, ethnic, and genetic factors. The aim of this study was to determine the expression of estrogen receptor alpha (ER-α) in MM in Isfahan, Iran. Materials and Methods: This study was planned as a descriptive, analytical, cross-sectional investigation. During this study, paraffin-embedded tissue blocks of patients with a histopathologic diagnosis of MM was studied for ER-α using immunohistochemistry (IHC). Results: In this study, 38 patients (female/male; 20/18) with a definite diagnosis of malignant cutaneous melanoma and mean age of 52.4 ± 11.2 years were investigated. Using envision IHC staining, there were not any cases with ER-α expression. Conclusion: In confirmation to the most previous studies, expression of ER-α was negative in MM. It is recommended to investigate the expression of estrogen receptor beta and other markers in MM.
      Citation: Advanced Biomedical Research 2017 6(1):14-14
      PubDate: Wed,22 Feb 2017
      DOI: 10.4103/2277-9175.200789
      Issue No: Vol. 6, No. 1 (2017)
       
  • Identification of Appropriate Housekeeping Genes for Gene Expression
           Analysis in Long-term Hypoxia-treated Kidney Cells

    • Authors: Shiva Moein, Shaghayegh Haghjooy Javanmard, Maryam Abedi, Mohammad Hosein Izadpanahi, Yousof Gheisari
      Pages: 15 - 15
      Abstract: Shiva Moein, Shaghayegh Haghjooy Javanmard, Maryam Abedi, Mohammad Hosein Izadpanahi, Yousof Gheisari
      Advanced Biomedical Research 2017 6(1):15-15
      Background: Selection of stably expressing housekeeping genes (HKGs) is a crucial step in gene expression analysis. However, there are no universal HKGs for all experiments, and they should be determined by each biologic condition. The aim of this study was to detect appropriate HKGs for kidney cells cultured in long-term hypoxia. Materials and Methods: Based on a screening step using a microarray data available from gene expression omnibus database, a set of candidate HKGs were chosen to be assessed in human kidney cells cultured in hypoxic or normoxic conditions for about 2 weeks in a time course manner. The stability of gene expression was assessed by refFinder, a web-based tool that integrates four computational programs (geNorm, Normfinder, BestKeeper, and the comparative ΔΔCt method). Results: GAPDH and ACTB were the most stable genes in hypoxia treated cells whereas, B2M and ACTB were the best HKGs in cells cultured in normoxia. When both hypoxia and normoxia treated cells from all time points were evaluated together, GAPDH and ACTB equally showed the most stability. Conclusion: As in relative quantification of real-time polymerase chain reaction data, the same HKGs should be selected for all groups, we believe that GAPDH and ACTB are suitable HKGs for studies on the effect of hypoxia on cultured kidney cells.
      Citation: Advanced Biomedical Research 2017 6(1):15-15
      PubDate: Wed,22 Feb 2017
      DOI: 10.4103/2277-9175.200790
      Issue No: Vol. 6, No. 1 (2017)
       
  • Malignant Transformation of an Intracranial Extradural Epidermoid Cyst
           into Squamous Cell Carcinoma Presented with Cerebrospinal Fluid Leakage

    • Authors: Bahram Seif, Reza Pourkhalili, Ahmad Shekarchizadeh, Parvin Mahzouni
      Pages: 16 - 16
      Abstract: Bahram Seif, Reza Pourkhalili, Ahmad Shekarchizadeh, Parvin Mahzouni
      Advanced Biomedical Research 2017 6(1):16-16
      We report a case of malignant transformation of an intracranial extradural epidermoid cyst into squamous cell carcinoma (SCC), that presented with cerebrospinal fluid (CSF) leakage at the time of recurrence. Intracranial epidermoid cysts are histologically benign and slow-growing neoplasms. They are congenital lesions that develop from ectodermal remnants during neuroembryogenesis. Malignant transformation of epidermoid cysts into SCC is very rare. Various clinical presentations of these tumors after malignant transformation are mentioned in the literature. None of the previous cases, presented with CSF leakage as the recent case did. In cases of malignant transformation, surgical resection and then adjuvant radiation therapy are highly recommended.
      Citation: Advanced Biomedical Research 2017 6(1):16-16
      PubDate: Wed,22 Feb 2017
      DOI: 10.4103/2277-9175.200791
      Issue No: Vol. 6, No. 1 (2017)
       
  • Treatment Outcome of the Drug-resistant Zoonotic Cutaneous Leishmaniasis
           by Glucantime

    • Authors: Simindokht Soleimanifard, Reza Arjmand, Sedighe Saberi, Mansoor Salehi, Seyed Hossain Hejazi
      Pages: 17 - 17
      Abstract: Simindokht Soleimanifard, Reza Arjmand, Sedighe Saberi, Mansoor Salehi, Seyed Hossain Hejazi
      Advanced Biomedical Research 2017 6(1):17-17
      Background: Resistance of Leishmania species to antimonial drugs has increased. Hence, in the present study Leishmania major isolates were collected from patients with resistance phenotype and the presence/absence of resistance to Glucantime was investigated. Materials and Methods: Samples were taken from 10 cutaneous leishmaniasis (CL) patients who had not responded to chemotherapy with Glucantime. Nested polymerase chain reaction (PCR) was performed to identify the isolated species. Stationary phase promastigotes were added to the grown, adhesive J774 macrophages. Values obtained from standard strain were compared with the test cultures after exposure to the medicine. In vivo, the effects of Glucantime were assessed by comparing the sizes and the parasite burden of the lesions on mouse model. Results: The results of amplified band on agarose gel demonstrated all samples were L. major. After exposure to medicine, a reduction of intracellular amastigotes to half was detected. In vivo, the parasite was eliminated in 90% of mice with lesions caused by both isolates of patients and standard L. major, and their lesions became smaller significantly. Conclusion: Pentavalent antimonial (SbV) salts are the main component of chemotherapy against leishmaniasis. However, the medicine has been found ineffective. In the present study, isolates from patients with no response to treatment had no significant difference from the standard L. major strain (as the sensitive strain). Therefore, in patients with resistance phenotype to Glucantime, the parasites did not actually have intrinsic resistance, i.e., environmental and host factors prevented the successful treatment of the disease.
      Citation: Advanced Biomedical Research 2017 6(1):17-17
      PubDate: Wed,1 Mar 2017
      DOI: 10.4103/2277-9175.201329
      Issue No: Vol. 6, No. 1 (2017)
       
  • Evaluation of Diagnostic Values of Clinical Assessment in Determining the
           Maturation of Arteriovenous Fistulas for Satisfactory Hemodialysis

    • Authors: Fereshteh Salimi, Shahab Shahabi, Hamid Talebzadeh, Amir Keshavarzian, Mohammad Pourfakharan, Mansour Safaei
      Pages: 18 - 18
      Abstract: Fereshteh Salimi, Shahab Shahabi, Hamid Talebzadeh, Amir Keshavarzian, Mohammad Pourfakharan, Mansour Safaei
      Advanced Biomedical Research 2017 6(1):18-18
      Background: Fistulas are the preferred permanent hemodialysis vascular access, but a significant obstacle to increasing their prevalence is the fistula's high “failure to mature” (FTM) rate. This study aimed to identify postoperative clinical characteristics that are predictive of fistula FTM. Materials and Methods: This descriptive cross-sectional study was performed on 80 end-stage renal disease patients who referred to Al Zahra Hospital, Isfahan, for brachiocephalic fistula placement. After 4 weeks, the clinical criteria (trill, firmness, vein length, and venous engorgement) examined and the fistulas situation divided to favorable or unfavorable by each criterion, and the results comprised with dialysis possibility. Data were analyzed with SPSS version 21. Diagnostic index for CLINICAL examination was calculated. Results: Among the 80 cases, 25 (31.2%) female and 55 (68.8%) male were studied with the mean age of 51.9 (standard deviation = 17) year ranged between 18 and 86 years old. Sixty-two (77.5%) cases had successful hemodialysis. All four clinical assessments were significantly more acceptable in patients with successful dialysis (P < 0.001). According to the results of our study, the accuracy of all physical assessments was above 70% and except vein length other criteria had a sensitivity and negative predictive value of 100%. In this study, firmness of vein has highest specificity and positive predictive value (83.9% and 64.3%, respectively). Conclusion: Results of our study showed that high sensitivity and relatively low specificity of the clinical criterion. It means that unfavorable results of each clinical criterion predict unfavorable dialysis. Clinical evaluation of a newly created fistula 4–6 weeks after surgery should be considered mandatory.
      Citation: Advanced Biomedical Research 2017 6(1):18-18
      PubDate: Wed,1 Mar 2017
      DOI: 10.4103/2277-9175.201330
      Issue No: Vol. 6, No. 1 (2017)
       
  • Evaluating Accuracy of Free-hand Pedicle Screw Insertion in Adolescent
           Idiopathic Scoliosis Using Postoperative Multi-Slice Computed Tomography
           Scan

    • Authors: Mohammadreza Etemadifar, Mohammadhossein Jamalaldini
      Pages: 19 - 19
      Abstract: Mohammadreza Etemadifar, Mohammadhossein Jamalaldini
      Advanced Biomedical Research 2017 6(1):19-19
      Background: Pedicle screw instrumentation has many advantages for correction of adolescent idiopathic scoliosis (AIS) deformity including better correction and fewer late complications. On the other hand, screw insertion in AIS is challenging. Intraoperative fluoroscopy or navigation techniques are expensive, time-consuming, and exposed to high radiation. Free-hand technique relies on the surgeon's experience and locating the pedicle entry point with anatomical landmarks. There are few studies that evaluated pedicle screw position accuracy with postoperative multi-slice computed tomography scan. Materials and Methods: We prospectively considered 38 consecutive AIS cases, who underwent corrective surgery with all pedicle screw technique. All the screws were inserted with free-hand technique using anatomic landmarks as a guide for an entry site. We divided pedicle penetration in medial, lateral, inferior, superior, and anterior vertebral body as Grades 0–4, that Grade 0 is fully contained within the pedicle, Grade 1 (<2 mm), Grade 2 (2.1–4 mm), Grade 3 (4.1–6 mm), and Grade 4 (>6 mm). Results: A total of 720 screws were inserted, of which 623 screws (86.5%) were perfect and 97 screws (13.5%) were misplaced. Of those which were misplaced, 39 screws (40.2%) were medial and 58 (59.8%) were lateral, which shows that the prevalence of lateral misplacement was more in comparison to medial misplacement. However, in all misplaced cases, the deviation of the screw was <2 mm (Grade 1). There was no misplacement in the inferior and superior. Conclusion: Pedicle screw insertion in AIS with the free-hand technique is a safe and reliable method.
      Citation: Advanced Biomedical Research 2017 6(1):19-19
      PubDate: Wed,1 Mar 2017
      DOI: 10.4103/2277-9175.201331
      Issue No: Vol. 6, No. 1 (2017)
       
  • Fractional Carbon Dioxide Laser and its Combination with Subcision in
           Improving Atrophic Acne Scars

    • Authors: Mohammad Ali Nilforoushzadeh, Gita Faghihi, Fariba Jaffary, Elaheh Haftbaradaran, Sayed Mohsen Hoseini, Nafiseh Mazaheri
      Pages: 20 - 20
      Abstract: Mohammad Ali Nilforoushzadeh, Gita Faghihi, Fariba Jaffary, Elaheh Haftbaradaran, Sayed Mohsen Hoseini, Nafiseh Mazaheri
      Advanced Biomedical Research 2017 6(1):20-20
      Background: Acne is a very common skin disease in which scars are seen in 95% of the patients. Although numerous treatments have been recommended, researchers are still searching for a single modality to treat the complication due to its variety in shape and depth. We compared the effects of fractional carbon dioxide (CO2) laser alone and in combination with subcision in the treatment of atrophic acne scars. Materials and Methods: This clinical trial study was performed in Skin Diseases and Leishmaniasis Research Center (Isfahan, Iran) during 2011–2012. Eligible patients with atrophic acne scars were treated with fractional CO2laser alone (five sessions with 3-week interval) on the right side of the face and fractional CO2laser plus subcision (one session using both with four sessions of fractional CO2laser, with 3-week interval) on the left side. The subjects were visited 1, 2, and 6 months after the treatment. Patient satisfaction rate was analyzed using SPSS 20 software. Results: The average of recovery rate was 54.7% using the combination method and 43.0% using laser alone (P < 0.001). The mean patient satisfaction was significantly higher with the combination method than laser alone (6.6 ± 1.2 vs. 5.2 ± 1.8; P < 0.001). Bruising was only seen with the combination method and lasted for 1 week in 57.0% and for 2 weeks in 43.0%. Erythema was seen in both methods. Postinflammatory pigmentation and hyperpigmentation were associated with combination method. No persistent side effects were seen after 6 months. Conclusion: Using a combination of subcision and laser had suitable results regarding scar recovery and satisfaction rate.
      Citation: Advanced Biomedical Research 2017 6(1):20-20
      PubDate: Wed,1 Mar 2017
      DOI: 10.4103/2277-9175.201332
      Issue No: Vol. 6, No. 1 (2017)
       
  • The Mediating Role of Mental Health in the Relations between Dietary
           Behaviors and General Health: A Cross-sectional Study

    • Authors: Shahrzad Nematollahi, Ammar Hassanzadeh Keshteli, Ahmad Esmaillzadeh, Hamidreza Roohafza, Hamid Afshar, Peyman Adibi, Mohammad Reza Maracy
      Pages: 21 - 21
      Abstract: Shahrzad Nematollahi, Ammar Hassanzadeh Keshteli, Ahmad Esmaillzadeh, Hamidreza Roohafza, Hamid Afshar, Peyman Adibi, Mohammad Reza Maracy
      Advanced Biomedical Research 2017 6(1):21-21
      Background: The aim of this study is to find a pathway to explaining the relations between dietary behaviors with mental health and psychological functioning. Materials and Methods: This cross-sectional study contains 4763 participants from the employees of Isfahan University of Medical Sciences. In this study, four questionnaires were administered which were provided as follows: demographic characteristics, 21-item dietary behaviors questionnaire, Hospital Anxiety and Depression Scale questionnaire, and 12-item General Health Questionnaire (GHQ-12). We started the analysis with the structural equation modeling (SEM) model with 4 unobserved latent and 16 observed variables. Results: The results show that the regression coefficient (standard error) of diet behavior on mental health and mental health on GHQ were − 1 (0.37) and 0.02 (0.01) with their P values as 0.007 and 0.01, respectively. For this model, the estimated root mean square error of approximation is 0.062 with 90% confidence interval of (0.060–0.065). In addition, the comparative fit indices (CFIs) were as 0.866 for incremental fit index and 0.866 for CFI. All these indices represent fairly good fit of the model to the data. Conclusion: We can conclude that “lower scores on diet behavior – higher scores on mental health problems” and “higher mean scores in depression and/or anxiety – higher scores in GHQ domains.” The SEM results showed that dietary behaviors have significance related to depression and/or anxiety and general health status.
      Citation: Advanced Biomedical Research 2017 6(1):21-21
      PubDate: Wed,1 Mar 2017
      DOI: 10.4103/2277-9175.201333
      Issue No: Vol. 6, No. 1 (2017)
       
  • Optimization of the Expression of DT386-BR2 Fusion Protein in Escherichia
           coli using Response Surface Methodology

    • Authors: Fatemeh Shafiee, Mohammad Rabbani, Ali Jahanian-Najafabadi
      Pages: 22 - 22
      Abstract: Fatemeh Shafiee, Mohammad Rabbani, Ali Jahanian-Najafabadi
      Advanced Biomedical Research 2017 6(1):22-22
      Background: The aim of this study was to determine the best condition for the production of DT386-BR2 fusion protein, an immunotoxin consisting of catalytic and translocation domains of diphtheria toxin fused to BR2, a cancer specific cell penetrating peptide, for targeted eradication of cancer cells, in terms of the host, cultivation condition, and culture medium. Materials and Methods: Recombinant pET28a vector containing the codons optimized for the expression of the DT386-BR2 gene was transformed to different strains of Escherichia coli (E. coli BL21 DE3, E. coli Rosetta DE3 and E. coli Rosetta-gami 2 DE3), followed by the induction of expression using 1 mM IPTG. Then, the strain with the highest ability to produce recombinant protein was selected and used to determine the best expression condition using response surface methodology (RSM). Finally, the best culture medium was selected. Results: Densitometry analysis of sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the expressed fusion protein showed that E. coli Rosetta DE3 produced the highest amounts of the recombinant fusion protein when quantified by 1 mg/ml bovine serum albumin (178.07 μg/ml). Results of RSM also showed the best condition for the production of the recombinant fusion protein was induction with 1 mM IPTG for 2 h at 37°C. Finally, it was established that terrific broth could produce higher amounts of the fusion protein when compared to other culture media. Conclusion: In this study, we expressed the recombinant DT386-BR2 fusion protein in large amounts by optimizing the expression host, cultivation condition, and culture medium. This fusion protein will be subjected to purification and evaluation of its cytotoxic effects in future studies.
      Citation: Advanced Biomedical Research 2017 6(1):22-22
      PubDate: Wed,1 Mar 2017
      DOI: 10.4103/2277-9175.201334
      Issue No: Vol. 6, No. 1 (2017)
       
  • Simple and Easy to Perform Preimplantation Genetic Diagnosis for
           β-thalassemia Major Using Combination of Conventional and Fluorescent
           Polymerase Chain Reaction

    • Authors: Rasoul Salehi, Sharifeh Khosravi, Mansour Salehi, Majid Kheirollahi, Hossein Khanahmad
      Pages: 23 - 23
      Abstract: Rasoul Salehi, Sharifeh Khosravi, Mansour Salehi, Majid Kheirollahi, Hossein Khanahmad
      Advanced Biomedical Research 2017 6(1):23-23
      Background: Thalassemias are the most common monogenic disorders in many countries throughout the world. The best practice to control the prevalence of the disease is prenatal diagnosis (PND) services. Extensive practicing of PND proved effective in reducing new cases but on the other side of this success high abortion rate is hided, which ethically unfair and for many couples, especially with a previous experience of a therapeutic abortion, or moral concerns, is not a suitable choice. Preimplantation genetic diagnosis (PGD) is a strong alternative to conventional PND. At present PGD is the only abortion free fetal diagnostic process. Considering the fact that there are more than 6000 single gene disorders affecting approximately 1 in 300 live-births, the medical need for PGD services is significant. Materials and Methods: In the present study development of a PGD protocol for a thalassemia trait couple using nested multiplex fluorescent polymerase chain reaction (PCR) for the combination of polymorphic linked short tandem repeat (STR) markers and thalassemia mutations is described. Restriction fragment length polymorphism used to discriminate between wild and mutated alleles. Results: In PGD clinical cycle, paternal and maternal alleles for D11S988 and D11S1338 STR markers were segregated as it was expected. PCR product for IVSII-1 mutation was subsequently digested with BtscI restriction enzyme to differentiate normal allele from the mutant allele. The mother's mutation, being a comparatively large deletion, was detectable through size differences on agarose gel. Conclusion: The optimized single cell protocol developed and evaluated in this study is a feasible approach for preimplantation diagnosis of β-thalassemia in our patients.
      Citation: Advanced Biomedical Research 2017 6(1):23-23
      PubDate: Tue,7 Mar 2017
      DOI: 10.4103/2277-9175.201682
      Issue No: Vol. 6, No. 1 (2017)
       
  • Identification of a New Single-nucleotide Polymorphism within the
           Apolipoprotein A5 Gene, Which is Associated with Metabolic Syndrome

    • Authors: Samaneh Salehi, Modjtaba Emadi-Baygi, Majdaddin Rezaei, Roya Kelishadi, Parvaneh Nikpour
      Pages: 24 - 24
      Abstract: Samaneh Salehi, Modjtaba Emadi-Baygi, Majdaddin Rezaei, Roya Kelishadi, Parvaneh Nikpour
      Advanced Biomedical Research 2017 6(1):24-24
      Background: Metabolic syndrome (MetS) is a common disorder which is a constellation of clinical features including abdominal obesity, increased level of serum triglycerides (TGs) and decrease of serum high-density lipoprotein-cholesterol (HDL-C), elevated blood pressure, and glucose intolerance. The apolipoprotein A5 (APOA5) is involved in lipid metabolism, influencing the level of plasma TG and HDL-C. In the present study, we aimed to investigate the associations between four INDEL variants of APOA5 gene and the MetS risk. Materials and Methods: In this case–control study, we genotyped 116 Iranian children and adolescents with/without MetS by using Sanger sequencing method for these INDELs. Then, we explored the association of INDELs with MetS risk and their clinical components by logistic regression and one-way analysis of variance analyses. Results: We identified a novel insertion polymorphism, c. *282–283 insAG/c. *282–283 insG variant, which appears among case and control groups. rs72525532 showed a significant difference for TG levels between various genotype groups. In addition, there were significant associations between newly identified single-nucleotide polymorphism (SNP) and rs72525532 with MetS risk. Conclusions: These results show that rs72525532 and the newly identified SNP may influence the susceptibility of the individuals to MetS.
      Citation: Advanced Biomedical Research 2017 6(1):24-24
      PubDate: Tue,7 Mar 2017
      DOI: 10.4103/2277-9175.201688
      Issue No: Vol. 6, No. 1 (2017)
       
  • The Investigation of Insulin Resistance in Two Groups of Epileptic
           Patients Treated with Sodium Valproate and Carbamazepine

    • Authors: Mohammad Reza Najafi, Bahareh Bazooyar, Mohammad Zare, Mohammad Reza Aghaghazvini, Behnaz Ansari, Ali Rajaei, Masoumeh Dashti
      Pages: 25 - 25
      Abstract: Mohammad Reza Najafi, Bahareh Bazooyar, Mohammad Zare, Mohammad Reza Aghaghazvini, Behnaz Ansari, Ali Rajaei, Masoumeh Dashti
      Advanced Biomedical Research 2017 6(1):25-25
      Background: Valproic acid (VPA) is a widely used broad-spectrum antiepileptic drug for therapy of generalized and focal epilepsies. Cross-sectional studies have suggested that valproate treatment may be associated with hyperinsulinemia. We decided to investigate hyperinsulinemia as a health-threatening side effect of VPA in Iranian epileptic patients. Materials and Methods: Body mass index (BMI), lipid profile, fasting serum insulin, fasting blood glucose (FBS), and homeostatic model assessment-insulin resistance (HOMA-IR) were measured in 30 VPA-treated epileptic patients and 30 controls (CBZ-treated). The Chi-square test, t-test, and Pearson correlation test were used. Results: BMI was higher in VPA group than in control group (25.7 ± 3.5 > 21.7 ± 4.1) (0.000 < 0.05). Prevalence of obesity was 16.6% in VPA group that was almost the same and even lower than general Iranian population. Serum triglyceride (TG) (150 ± 77.2) was higher than CBZ group (114 ± 35.2) (P = 0.023 < 0.05). However, serum high-density lipoprotein level was lower in VPA group than controls (45.2 ± 11.7 < 54.4 ± 13.9) (P = 0.008 < 0.05). Serum insulin, FBS, HOMA-IR, cholesterol, and low-density lipoprotein did not demonstrate statistically significant differences between the two groups (P > 0.05). Conclusion: Despite the majority of previous studies that are against VPA and according to our study, VPA could be prescribed safely and it may not cause IR and its complications.
      Citation: Advanced Biomedical Research 2017 6(1):25-25
      PubDate: Tue,7 Mar 2017
      DOI: 10.4103/2277-9175.201689
      Issue No: Vol. 6, No. 1 (2017)
       
  • Structural Insight into Anaphase Promoting Complex 3 Structure and Docking
           with a Natural Inhibitory Compound

    • Authors: Hamzeh Rahimi, Mohammad Ali Shokrgozar, Armin Madadkar-Sobhani, Reza Mahdian, Alireza Foroumadi, Morteza Karimipoor
      Pages: 26 - 26
      Abstract: Hamzeh Rahimi, Mohammad Ali Shokrgozar, Armin Madadkar-Sobhani, Reza Mahdian, Alireza Foroumadi, Morteza Karimipoor
      Advanced Biomedical Research 2017 6(1):26-26
      Background: Anaphase promoting complex (APC) is the biggest Cullin-RING E3 ligase and is very important in cell cycle control; many anti-cancer agents target this. APC controls the onset of chromosome separation and mitotic exit through securin and cyclin B degradation, respectively. Its APC3 subunit identifies the APC activators-Cdh1 and Cdc20. Materials and Methods: The structural model of the APC3 subunit of APC was developed by means of computational techniques; the binding of a natural inhibitory compound to APC3 was also investigated. Results: It was found that APC3 structure consists of numerous helices organized in anti-parallel and the overall model is superhelical of tetratrico-peptide repeat (TPR) domains. Furthermore, binding pocket of the natural inhibitory compound as APC3 inhibitor was shown. Conclusion: The findings are beneficial to understand the mechanism of the APC activation and design inhibitory compounds.
      Citation: Advanced Biomedical Research 2017 6(1):26-26
      PubDate: Tue,7 Mar 2017
      DOI: 10.4103/2277-9175.201683
      Issue No: Vol. 6, No. 1 (2017)
       
  • Proteus Syndrome with Arteriovenous Malformation

    • Authors: Ali Asilian, Atefeh Sadat Kamali, Nabet Tajmir Riahi, Neda Adibi, Fatemeh Mokhtari
      Pages: 27 - 27
      Abstract: Ali Asilian, Atefeh Sadat Kamali, Nabet Tajmir Riahi, Neda Adibi, Fatemeh Mokhtari
      Advanced Biomedical Research 2017 6(1):27-27
      Proteus syndrome is a rare sporadic disorder that appears with localized macrosomia, congenital lipomatosis, and slow flow vascular malformations, connective tissue nevus, and epidermal nevus. There are usually some manifestations at birth. The vascular abnormalities that have been reported in Proteus syndrome are capillary and slow flow venous malformation. We report a case of a 10-year-old boy with confirmed Proteus syndrome characterized by high flow vascular malformation (arteriovenous [AV] malformation) unlike the usual vascular malformations seen in this syndrome. This case adds a new perspective to the established clinical findings of the Proteus syndrome.
      Citation: Advanced Biomedical Research 2017 6(1):27-27
      PubDate: Tue,7 Mar 2017
      DOI: 10.4103/2277-9175.201684
      Issue No: Vol. 6, No. 1 (2017)
       
  • Repeated Remote Ischemic Conditioning Effect on Ankle-brachial Index in
           Diabetic Patients - A Randomized Control Trial

    • Authors: Najmeh Shahvazian, Mansour Rafiee, Masoud Rahmanian, Seyed Kazem Razavi-ratki, Mohammad Hadi Farahzadi
      Pages: 28 - 28
      Abstract: Najmeh Shahvazian, Mansour Rafiee, Masoud Rahmanian, Seyed Kazem Razavi-ratki, Mohammad Hadi Farahzadi
      Advanced Biomedical Research 2017 6(1):28-28
      Background: Remote ischemic preconditioning (RIPC) is a phenomenon where a short period of ischemia in one organ protects against further ischemia in the other organs. We hypothesized that RIPC occurring in diabetic patients with ankle brachial index (ABI) between 0.70 and 0.90 were included with peripheral arterial disease, would make the better coronary flow resulted in the increasing ABI. Materials and Methods: This randomized clinical trial study was done in the Afshar Cardiovascular Hospital in Yazd between 2013 and 2014. Sixty participants were randomly divided into two groups (intervention and control groups). The intervention group was undergoing RIPC, and the control group was tested without RIPC. RIPC was stimulated by giving three cycles of 5 min of ischemia followed by 5 min of reperfusion of both upper arms using a blood pressure cuff inflated to 200 mm Hg (n = 30). This was compared with no RIPC group which consisted of placing a deflated blood pressure cuff on the upper limbs (n = 30). Results: The mean of ABI level before intervention in the RIPC and control group group was 0.82 ± 0.055 and 0.83 ± 0.0603 (P = 0.347) respectively, with no significant difference. It was 0.86 ± 0.066 in the RIPC group compared the control 0.83 ± 0.0603 (P = 0.046). So levels of ABI were greater after intervention in the RIPC group. The mean of ABI level increase from 0.82 ± 0.05 to 0.86 ± 0.06 in RIPC group (P = 0.008). So the intervention group showed a significant increase in ABI. Conclusions: RIPC through using a simple, noninvasive technique, composing three cycles of 5 min-ischemia of both upper arms, showing a significant increase in ABI level in diabetic patients.
      Citation: Advanced Biomedical Research 2017 6(1):28-28
      PubDate: Tue,7 Mar 2017
      DOI: 10.4103/2277-9175.201685
      Issue No: Vol. 6, No. 1 (2017)
       
  • Presentation of Placental Site Trophoblastic Tumor with Amenorrhea

    • Authors: Fariba Behnamfar, Safoura Rouholamin, Mahboubeh Esteki
      Pages: 29 - 29
      Abstract: Fariba Behnamfar, Safoura Rouholamin, Mahboubeh Esteki
      Advanced Biomedical Research 2017 6(1):29-29
      Placental site throphoblastic tumor (PSTT) is a rare manifestation of gestational trophoblastic neoplasia that may complicate any type of pregnancy. The disease is unique from other type, and is defined by slow growth, low human chorionic gonadotropin (hCG) serum levels, the late-onset metastatic potential, and most significantly, insensitivity to chemotherapy. We describe a case of a 31-year-old woman with prolonged amenorrhea and slightly elevated serum beta hCG (βhCG) level, referred for termination of abnormal pregnancy. During curettage, necrotic tissue was removed and severs vaginal bleeding was controlled with medical therapy. Histology examination showed neoplastic intermediate trophoblastic cells with invasion to the vessel wall compatible with PSTT. After that, hysterectomy was down and serum βhCG declined to undetectable level 2 weeks after surgery and was followed for 2 years without complication.
      Citation: Advanced Biomedical Research 2017 6(1):29-29
      PubDate: Tue,7 Mar 2017
      DOI: 10.4103/2277-9175.201686
      Issue No: Vol. 6, No. 1 (2017)
       
  • Comparison of Ifosfamide, Carboplatin and Etoposide versus Etoposide,
           Steroid, and Cytarabine Cisplatin as Salvage Chemotherapy in Patients with
           Refractory or Relapsed Hodgkin's lymphoma

    • Authors: Valiollah Mehrzad, Farzaneh Ashrafi, Ali Reza Farrashi, Reyhaneh Pourmarjani, Mehdi Dehghani, Armindokht Shahsanaei
      Pages: 30 - 30
      Abstract: Valiollah Mehrzad, Farzaneh Ashrafi, Ali Reza Farrashi, Reyhaneh Pourmarjani, Mehdi Dehghani, Armindokht Shahsanaei
      Advanced Biomedical Research 2017 6(1):30-30
      Background: Refractory or relapsed Hodgkin's disease (HD) occurs in 10-50% of patients. The treatment of choice for these patients is high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT). Response to salvage chemotherapy (SCT) partial remission (PR) is necessary before HDCT with ASCT. However, its applicability is restricted mostly to patients responding to salvage chemotherapy. Optimal salvage regimen for these patients is unclear. In this study, our aim was to compare the efficacy profiles of ifosfamide, carboplatin, and etoposide (ICE) and etoposide-steroid-cytarabine-cisplatin (ESHAP) (cytosine arabinoside, cisplatin, and dexamethasone) regimens in the salvage treatment of relapsed or refractory HD. Materials and Methods: In this retrospective analysis, 114 patients with primary refractory or relapsed HD who received ICE or ESHAP salvage regimen were included. Results: Of 114 patients, 47 (41.2%) were females and the median age was 31.5 years. Response could be evaluated in 114 patients. Of 114 patients, 38 (33%) achieved complete remission (CR) and 21 (18.4%) achieved PR, leading to an overall response rate (ORR: CR + PR) of 51.4%. In the evaluable ICE group (n = 41), rates of CR, PR, and ORR were 21.9%, 17.1%, and 39% and in the ESHAP group (n = 73), rates of CR, PR, and ORR were 39.7%, 19.2%, and 58.9% (for ORR,P = 0.04), respectively. Conclusion: In patients with relapsed or refractory HD, treatment with ESHAP seems to have higher rates of response than ICE regimen does.
      Citation: Advanced Biomedical Research 2017 6(1):30-30
      PubDate: Tue,7 Mar 2017
      DOI: 10.4103/2277-9175.201687
      Issue No: Vol. 6, No. 1 (2017)
       
  • Probiotics: A New Era of Biotherapy

    • Authors: Abhijeet Alok, Indra Deo Singh, Shivani Singh, Mallika Kishore, Prakash Chandra Jha, Md. Asad Iqubal
      Pages: 31 - 31
      Abstract: Abhijeet Alok, Indra Deo Singh, Shivani Singh, Mallika Kishore, Prakash Chandra Jha, Md. Asad Iqubal
      Advanced Biomedical Research 2017 6(1):31-31
      Probiotics or health-beneficial bacteria have only recently been introduced in dentistry after years of successful use in mainly gastrointestinal disorders. The concept of bacteriotherapy was first introduced in the beginning of 20th century. They are administered in different quantities that allow for colon colonization. These products help in stimulating health promoting flora and also suppressing the pathologic colonization and disease spread. The use of probiotic plays an important aspect in dentistry too, ever since the oral infections occupied the prime spot among the other infections affecting the humans. Probiotics strengthen the immune system to combat allergies, stress, exposure to toxic substances, and other diseases. This review is an attempt to discuss briefly the role of probiotics in oral health.
      Citation: Advanced Biomedical Research 2017 6(1):31-31
      PubDate: Tue,7 Mar 2017
      DOI: 10.4103/2277-9175.192625
      Issue No: Vol. 6, No. 1 (2017)
       
  • Mutation in &#948;-Sg Gene in Familial Dilated Cardiomyopathy

    • Authors: Marzieh Asadi, Roger Foo, Ahmad Reza Salehi, Rasoul Salehi, Mohammad Reza Samienasab
      Pages: 32 - 32
      Abstract: Marzieh Asadi, Roger Foo, Ahmad Reza Salehi, Rasoul Salehi, Mohammad Reza Samienasab
      Advanced Biomedical Research 2017 6(1):32-32
      Background: Mutations in different genes including dystrophin-associated glycoprotein complex caused familial dilated cardiomyopathy which is a genetically heterogeneous disease. The δ-SG gene contains nine exons spanning a 433-kb region of genomic DNA. It encodes a 35-kDa, singlepass, and type II transmembrane glycoprotein. Materials and Methods: In this study for the first time in Iran we screened 6 patients of a large family that they had positive family history of MI or sudden death by next generation sequencing method. Results: By employing NGS method we found missense mutation (p.R97Q) of δ-SG gene in 2 of 6 patients. Conclusions: The missense mutation (p.R97Q) in familial DCM patients is reported for the first time in Iranian patients with cardiac disease. Although this mutation is already known in other populations in Iran, it is not reported before.
      Citation: Advanced Biomedical Research 2017 6(1):32-32
      PubDate: Tue,7 Mar 2017
      DOI: 10.4103/2277-9175.188492
      Issue No: Vol. 6, No. 1 (2017)
       
  • Comparison of the Frequency of Y-short Tandem Repeats Markers between
           Sadat and Non-Sadat Populations in Isfahan Province of Iran

    • Authors: Reihaneh Seyedebrahimi, Ebrahim Esfandiari, Bahman Rashidi, Rasoul Salehi, Ali Gholami Dahghi, Shahriar Dabiri, Majid Kheirollahi
      Pages: 33 - 33
      Abstract: Reihaneh Seyedebrahimi, Ebrahim Esfandiari, Bahman Rashidi, Rasoul Salehi, Ali Gholami Dahghi, Shahriar Dabiri, Majid Kheirollahi
      Advanced Biomedical Research 2017 6(1):33-33
      Background: Y chromosome is one of the two sex chromosomes and is male specific. Due to limited genetic exchange, the main part of that is passed virtually unchanged from one generation to next generation. The short tandem repeats (STRs) are almost constant on chromosomes that make them as an appropriate factor for use in population genetic studies. In this study, we used the STRs of Y chromosome markers in Sadat families and comparison with other families was investigated. Materials and Methods: In this study, sampling was done from fifty unrelated males of Sadat families and fifty unrelated males of non-Sadat families. After the extraction of DNA from blood samples and primer design, polymerase chain reaction (PCR) was performed for each primer pairs separately. The PCR products were run on agarose gel that followed by running on polyacrylamide gel for better resolution. In addition, some sequenced samples were used as identified markers to determine the length of other alleles in polyacrylamide gel. Results: The survey of six STR in two case and control groups was carried out, and analysis revealed that the frequency of some alleles is different in case group compared to control group. Allele frequency of the markers DYS392, DYS393, DYS19, DYS390, DYS388, and DYS437 on the Y chromosome in Sadat families was quite different in comparison with other families. Conclusions: The reason for these differences in allele frequencies of the Sadat family in comparison with other families is having a common ancestor.
      Citation: Advanced Biomedical Research 2017 6(1):33-33
      PubDate: Tue,7 Mar 2017
      DOI: 10.4103/2277-9175.188493
      Issue No: Vol. 6, No. 1 (2017)
       
  • A Comparison of Betamethasone Valerate 0.1% Cream Twice Daily Plus Oral
           Simvastatin Versus Betamethasone Valerate 0.1% Cream Alone in the
           Treatment of Vitiligo Patients

    • Authors: Fariba Iraji, Seyed Hossin Banihashemi, Gita Faghihi, Zabihollah Shahmoradi, Nabet Tajmirriahi, Safoura Bokaie Jazi
      Pages: 34 - 34
      Abstract: Fariba Iraji, Seyed Hossin Banihashemi, Gita Faghihi, Zabihollah Shahmoradi, Nabet Tajmirriahi, Safoura Bokaie Jazi
      Advanced Biomedical Research 2017 6(1):34-34
      Background: Vitiligo, a common disorder of depigmentation, is often difficult to treat. Corticosteroids are known to be effective, but with modest results. Although simvastatin has been reported to be effective for immunorelated dermatologic disorders including vitiligo, controlled trials are lacking. This study was conducted to compare the efficacy of topical betamethasone valerate 0.1% cream (as a standard method of treatment for vitiligo) versus a combination of betamethasone valerate plus oral simvastatin in the treatment of vitiligo. Materials and Methods: Eighty-eight subjects with symmetric vitiligo who had body surface involvement up to 20% were divided randomly into two groups. Group A were treated with betamethasone valerate 01% cream twice daily and Group B with betamethasone valerate 01% cream twice daily and oral simvastatin 80 mg daily for 12 weeks. Finally, 46 patients completed treatment after 12 weeks in both groups. The results were evaluated by a blind dermatologist using Vitiligo Area Scoring Index (VASI) score at baseline, 4th, 8th, and 12th week of treatment. In a similar way, subjective assessment performed by patients based on photo evaluation at the end of the study. Results: Despite a continuous reduction in VASI score in both groups, according to both physician (P = 0.13) and patient (P = 0.374) assessment oral simvastatin was not statistically more effective than conventional treatment of vitiligo. Conclusion: This study indicates that oral simvastatin is not associated with significant impacts in the treatment of vitiligo as compared to other inflammatory dermatologic conditions such as psoriasis. Indeed, other studies should be initiated regarding exact molecular and cellular effects of statins in the treatment of vitiligo.
      Citation: Advanced Biomedical Research 2017 6(1):34-34
      PubDate: Tue,28 Mar 2017
      DOI: 10.4103/2277-9175.203159
      Issue No: Vol. 6, No. 1 (2017)
       
  • Is it Necessary to Perform Nephrostography before Tube Removal after
           Percutaneous Nephrolithotomy

    • Authors: Mehrdad Mohammadi Sichani, Masih Babaeian, Saeid Haghdani, Farshid Alizadeh, Hamid Mazdak, Mazaher Hadi, Mohammadhatef Khorrami
      Pages: 35 - 35
      Abstract: Mehrdad Mohammadi Sichani, Masih Babaeian, Saeid Haghdani, Farshid Alizadeh, Hamid Mazdak, Mazaher Hadi, Mohammadhatef Khorrami
      Advanced Biomedical Research 2017 6(1):35-35
      Background: The aim of this study is the caparison of the complications rate among the patients which underwent nephrostomy removal with and without performing nephrostography. Materials and Methods: Between October 2010 and November 2011, 200 patients who underwent standard percutaneous nephrolithotomy (PCNL) procedures were included in this study. The patients were randomly assigned into two groups, Group A (n = 100) did not undergo the antegrade nephrostography on postoperative day 2 and the patients were discharged keeping the nephrostomy until postoperative day 3, while in Group B (n = 100) the nephrostomy tube was removed on postoperative day 3 after antegrade nephrostography demonstrating ureteral drainage down to the bladder. Postoperative complications in both groups were recorded and compared between two groups. Results: A total of 200 patients were treated with standard PCNL. The persistent leakage of urine after removal of the nephrostomy tube was encountered in 5 (5.0%) and 3 (3%) of patients in Groups 1 and 2, respectively. Urinary leakage was resolved with conservative management in 3 and 2 patients of Groups 1 and 2, respectively, but a double-J stent was inserted in 2 and 1 patients in each group because of persistent leakage of urine more than 1-week. The two groups show comparable complications such as prolonged urinary leakage which managed in a similar manner, however, postoperative hospital stay was lesser in Group 1. Conclusion: Our results revealed postoperative performing nephrostogramy before tube removal changed the planning of complications such as prolonged urinary leakage and could be omitted in cases.
      Citation: Advanced Biomedical Research 2017 6(1):35-35
      PubDate: Tue,28 Mar 2017
      DOI: 10.4103/2277-9175.203160
      Issue No: Vol. 6, No. 1 (2017)
       
  • Bone Density in Postmenopausal Women with or without Breast Arterial
           Calcification

    • Authors: Atoosa Adibi, Farnaz Rabani, Silva Hovsepian
      Pages: 36 - 36
      Abstract: Atoosa Adibi, Farnaz Rabani, Silva Hovsepian
      Advanced Biomedical Research 2017 6(1):36-36
      Background: Identification of osteoporosis in women in order to prevent its related morbidity and mortality is considered a priority. Routine mammography is performed on all menopausal women as a screening tool. Determination of the relation between breast arterial calcification (BAC) on mammography and the bone density of this high-risk population could help us to determine those with osteoporosis. The aim of this study was to investigate the mentioned probable relation between BAC and osteoporosis. Materials and Methods: In this cross-sectional study, menopausal women referred for annual screening mammography were enrolled. According to the results of mammography, they were classified into two groups: menopausal women with and without calcification of breast arteries. The selected women were referred for bone mineral density (BMD) evaluation by dual-energy x-ray absorptiometry (DXA). The results of BMD were compared between the two studied groups. Results: In this study, BMD was measured in 43 and 45 menopausal women with and without BAC, respectively. After age adjustment the difference between BMD measurements were not statistically significantly different (P > 0.05). There was a significant negative correlation between age and lumbar (P = 0.002, r = -0.42) and hip bone (P = 0.000, r = -0.67) density in menopausal women with BAC. Conclusion: The results of the current study indicated that there was no significant relationship between BAC and BMD in our studied population, but it seems that increasing age has an important role in both developing BAC and reducing BMD. For obtaining more conclusive results, further studies with larger sample sizes and considering the severity of BAC is recommended.
      Citation: Advanced Biomedical Research 2017 6(1):36-36
      PubDate: Tue,28 Mar 2017
      DOI: 10.4103/2277-9175.203161
      Issue No: Vol. 6, No. 1 (2017)
       
  • Levamisole as an Adjuvant to Short-Course Therapy in Newly Diagnosed
           Pulmonary Tuberculosis Patients

    • Authors: Chetna Ashok Shamkuwar, Sushant Hiraman Meshram, Sunil M Mahakalkar
      Pages: 37 - 37
      Abstract: Chetna Ashok Shamkuwar, Sushant Hiraman Meshram, Sunil M Mahakalkar
      Advanced Biomedical Research 2017 6(1):37-37
      Background: The estimated incidence and prevalence of tuberculosis in India are 2.1 and 2.6 million cases respectively. Immunotherapy may shorten tuberculosis treatments and improve the immunity of individuals as well. Hence we study the efficacy of levamisole (LVM) (immunomodulator) as an adjuvant to chemotherapy of pulmonary tuberculosis patients. Materials and Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted for 21 months in newly diagnosed sputum positive pulmonary tuberculosis patients. Patients were subjected initially to clinical examination, sputum acid-fast bacilli smear and culture, tuberculin skin test and weight record. During follow-up, above investigations were repeated. Sixty-five patients were randomly assigned into two groups to receive either tab LVM 100 mg once in a day or matching placebo, orally as a single dose, thrice a week, for 2 months with short-course antituberculosis chemotherapy. Results: Sputum negativity at 1 week was observed in 11 (44%) patients in LVM group whereas only 3 (12%) in placebo group. All the patients 25 (100%) in LVM group were sputum negative compared to 14 (56%) in placebo group by the end of 3 weeks. In LVM group, 24 (96%) and 11 (44%) patients in placebo group show radiological improvement at 2 months. A direct correlation existed between quantum of immune response and weight gain with LVM. LVM rendered all anergic patients to positive tuberculin reactors. In LVM group, patients with initial Mantoux ≥20 mm and advanced cavitary disease, there was decrease in tuberculin reaction size. Conclusion: Adjuvant immunomodulation with levamisole has the potential of shortening the total duration of antitubercular therapy.
      Citation: Advanced Biomedical Research 2017 6(1):37-37
      PubDate: Tue,28 Mar 2017
      DOI: 10.4103/2277-9175.203162
      Issue No: Vol. 6, No. 1 (2017)
       
  • The Effect of Active Treatment and Visit Compared to Conventional
           Treatment, on Preventing Recurrent Suicidal Attempts: A Randomized
           Controlled Clinical Trial

    • Authors: Seyed Ghafur Mousavi, Marayam Nader Tehrani, Mohammadreza Maracy
      Pages: 38 - 38
      Abstract: Seyed Ghafur Mousavi, Marayam Nader Tehrani, Mohammadreza Maracy
      Advanced Biomedical Research 2017 6(1):38-38
      Background: Suicide is a major problem, and its prevention is a global priority. In many cases, suicide attempter attempts to do it again after the rescue. In current study we aimed to compare active visit and treatment of patients in a periodic manner with treatment as usual, in the prevention of recurrent suicidal attempts. Materials and Methods: This study was a randomized controlled clinical trial which was conducted in Isfahan Noor Hospital's Emergency Center on 60 patients in 2013-2014. The samples were selected using simple random sampling and they were assigned into two groups: The conventional treatment group (treatment as usual) (30 patients), and visit and active treatment (30 patients). In the intervention group, there were ten follow-ups by a face-to-face visit over 12 months, and six follow-ups by phone call in control group. Through the completion of the initial and follow-up questionnaire evaluation was performed. The data were analyzed using Cochran test, and repeated measure (ANOVA). Results: During the 12-month follow-up visit and active treatment, significant difference in reducing suicidal thoughts (P = 0.003) was observed and an increase in the life expectancy (P = 0.001), interest and motivation in life (P = 0.001) was found in the intervention group, and also nonsignificant reduction was found in the rate of suicidal attempts. Conclusion: Visit and active treatment is useful in suicide attempters and it can helps in preventing recurrent suicide attempt as a preventive program by increasing hope and reducing suicidal thoughts.
      Citation: Advanced Biomedical Research 2017 6(1):38-38
      PubDate: Mon,17 Apr 2017
      DOI: 10.4103/2277-9175.204586
      Issue No: Vol. 6, No. 1 (2017)
       
  • Intratumoral and Peritumoral Mast Cells in Malignant Melanoma: An
           Immunohistochemical Study

    • Authors: Parvin Rajabi, Azam Bagheri, Mohssen Hani
      Pages: 39 - 39
      Abstract: Parvin Rajabi, Azam Bagheri, Mohssen Hani
      Advanced Biomedical Research 2017 6(1):39-39
      Background: The aim of the current study was to determine mast cell infiltration in malignant melanoma by immunohistochemistry method and its relationship with some of the cancer prognostic factors, including age, sex, and depth of the tumor. Materials and Methods: In this retrospective analytic cross-sectional study, paraffin-embedded tissue blocks of patients with cutaneous malignant melanoma who had undergone excisional biopsy were studied. Mast cells count in studied cases in different stages of the tumor depth was evaluated by mast cell tryptase immunohistochemistry method. Mast cells infiltration was evaluated both inside the tumor and peritumoral area. Tumor infiltrating lymphocytes (TILs) was also determined. Distribution of intratumoral and peritumoral mast cells and TILs was compared in different stages tof tumor depth. Results: In this study, 51 cases with melanoma were studied. Mean ± standard deviation (SD) of intratumoral mast cells in stages 1, 2, and 3 was 9.4 ± 4.2, 10.8 ± 5.1, and 2.1 ± 2.3, respectively (P = 0.000). Mean ± SD of peritumoral mast cells in stages 1, 2 and 3 was 13.4 ± 2.4, 16.6 ± 2.4 and 8.2 ± 4.6, respectively (P = 0.000). There was a significant direct relationship between depth of the tumor and TIL (P = 0.000) and distribution of intratumoral (P = 0.000) and peritumoral mast cells (P = 0.000). Conclusion: Lower distribution of intratumoral and peritumoral mast cells and TILs in higher stages of tumor depth in malignant melanoma suggests a possible inhibitory effect of infiltrating mast cells and lymphocytes on the progression of this tumor.
      Citation: Advanced Biomedical Research 2017 6(1):39-39
      PubDate: Mon,17 Apr 2017
      DOI: 10.4103/2277-9175.204592
      Issue No: Vol. 6, No. 1 (2017)
       
  • The Effects of Melatonin in Patients with Nonalcoholic Fatty Liver
           Disease: A Randomized Controlled Trial

    • Authors: Hassan Pakravan, Mehdi Ahmadian, Ali Fani, Davood Aghaee, Sareh Brumanad, Bahram Pakzad
      Pages: 40 - 40
      Abstract: Hassan Pakravan, Mehdi Ahmadian, Ali Fani, Davood Aghaee, Sareh Brumanad, Bahram Pakzad
      Advanced Biomedical Research 2017 6(1):40-40
      Background: This study was designed to evaluate the effect of melatonin on nonalcoholic fatty liver disease (NAFLD) in compared to placebo. Materials and Methods: A total of 100 patients with histopathological diagnosis NAFLD in two groups of case and control received oral melatonin or placebo thrice daily for 3 months. Collected data were weight, waist, systolic blood pressure (SBP), diastolic blood pressure (DBP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), high sensitive C-reactive protein (hsCRP), fatty liver grade, and side effects which were measured at baseline and after treatment period using standard clinical chemistry techniques. Results: Before treatment the mean of weight, waist, SBP, DBP, ALT, AST, and hsCRP between cases and controls were similar (P > 0.5). After treatment, only the differences in the mean of hsCRP in cases was significantly lower than controls (P = 0.003). In case group, all variables after treatment were significantly decreased compare to baseline (P > 0.5) and only AST after treatment was similar to before treatment (P > 0.5). The mean of a decrease in the level of weight, waist, SBP, and ALT were not statistically significant between groups (P > 0.5). In the case group in compare to control group the level of DBP, AST, and hsCRP significantly more decreased. After treatment fatty, liver grade was statistically improved in more cases than controls (P = 0.001). Side effects were similar between the two groups. Conclusion: Melatonin significantly decreases liver enzymes, so the use of melatonin in patients with NAFLD can be effective.
      Citation: Advanced Biomedical Research 2017 6(1):40-40
      PubDate: Mon,17 Apr 2017
      DOI: 10.4103/2277-9175.204593
      Issue No: Vol. 6, No. 1 (2017)
       
  • Prevalence of Acquired Carbapenemase Genes in Klebsiella Pneumoniae by
           Multiplex PCR in Isfahan

    • Authors: Farzin Khorvash, Mohammed Reza Yazdani, Ali Asghar Soudi, Shiva Shabani, Nirvana Tavahen
      Pages: 41 - 41
      Abstract: Farzin Khorvash, Mohammed Reza Yazdani, Ali Asghar Soudi, Shiva Shabani, Nirvana Tavahen
      Advanced Biomedical Research 2017 6(1):41-41
      Background: Multi-drug resistant Klebsiella pneumoniae has been considered as a serious global threat. This study was done to investigate carbapenemase producing genomes among K. pneumoniae isolates in Isfahan, Central Iran. Materials and Methods: In a cross-sectional study from 2011 to 2012, 29 carbapenem resistant (according to disc diffusion method) carbapenemase producing (according to modified Hodge test) K. pneumoniae strains were collected from Intensive Care Unit (ICUs) of Al-Zahra referral Hospital. In the strains with the lack of sensitivity to one or several carbapenems, beta-lactams, or beta-lactamases, there has been performed modified Hodge test to investigate carbapenmase and then only strains producing carbapenmases were selected for molecular methods. Results: In this study, there have been 29 cases of K. pneumoniae isolated from hospitalized patients in the (ICU). Three cases (10.3%) contained blaVIM, 1 case (3.4%) contained blaIMP, and 1 case (3.4%) contained blaOXA. The genes blaNDM and blaKPC were not detected. Then, 16 cases (55.2%) from positive cases of K. pneumoniae were related to the chip, 4 cases (13.8%) to catheter, 6 cases (20.7%) to urine, and 3 cases (10.3%) to wound. Conclusion: It is necessary to monitor the epidemiologic changes of these carbapenemase genes in K. pneumoniae in our Hospital. More attention should be paid to nosocomial infection control measures. Other carbapenemase producing genes should be investigated.
      Citation: Advanced Biomedical Research 2017 6(1):41-41
      PubDate: Mon,17 Apr 2017
      DOI: 10.4103/2277-9175.204594
      Issue No: Vol. 6, No. 1 (2017)
       
  • Investigation of Prognostic Factors and Survival without Recurrence in
           Patients with Breast Cancer

    • Authors: Ahmad Abdollahi, Hamzeh Saleh Zadeh, Mojtaba Akbari, Sedigheh Tahmasbi, Abdolrasoul Talei, Jafar Hassanzadeh
      Pages: 42 - 42
      Abstract: Ahmad Abdollahi, Hamzeh Saleh Zadeh, Mojtaba Akbari, Sedigheh Tahmasbi, Abdolrasoul Talei, Jafar Hassanzadeh
      Advanced Biomedical Research 2017 6(1):42-42
      Background: One of the major consequences of breast cancer is the recurrence of the disease. The objective of present study was to estimate the 7-year survival without recurrence as well as the effective prognostic factors in recurrence. Materials and Methods: This historical cohort survival analysis was conducted on 1329 patients diagnosed with breast cancer in Motahari Breast Clinic, Shiraz, Iran between 2004 and 2011. We estimated the rate of survival without recurrence through the Kaplan–Meier method and the difference between the survival curves was investigated using the log-rank test. Furthermore, Cox regression model was used to model the effective factors in local recurrence as well as metastasis. Results: The mean age of the patients was 54.8 ± 11.4 years. Estrogen receptor positive, progesterone receptor positive, and human epidermal growth factor receptor-2 positive were observed in 70.6%, 66.6%, and 34.4% of the cases, respectively. The mean of the follow-up period was 3.7 ± 1.8 years in all patients. The results of the Kaplan–Meier method revealed 1-, 3-, 5-, and 7-year rate of survival without recurrence as 96.4%, 78.4%, 66.3%, and 54.8%, respectively. There was a significant relationship between survival without recurrence and histology grade (hazard ratio [HR] = 1.66, P = 0.009), neural invasion (HR = 1.74, P = 0.006), and progesterone receptors (HR = 0.69, P = 0.031). Conclusion: In this study, the rate of survival without recurrence in breast cancer was 54.8%. Among factors, histology grade and neural involvement at the time of diagnosis increased the chance of recurrence and progesterone receptors caused a longer interval between diagnosis and recurrence.
      Citation: Advanced Biomedical Research 2017 6(1):42-42
      PubDate: Mon,17 Apr 2017
      DOI: 10.4103/2277-9175.204595
      Issue No: Vol. 6, No. 1 (2017)
       
  • Evaluation of Energy Balance on Human Telomerase Reverse Transcriptase
           (hTERT) Alternative Splicing by Semi-quantitative RT-PCR in Human
           Umbilical Vein Endothelial Cells

    • Authors: Mohaddeseh Behjati, Mohammad Hashemi, Mohammad Kazemi, Mansoor Salehi, Shaghayegh Haghjooy Javanmard
      Pages: 43 - 43
      Abstract: Mohaddeseh Behjati, Mohammad Hashemi, Mohammad Kazemi, Mansoor Salehi, Shaghayegh Haghjooy Javanmard
      Advanced Biomedical Research 2017 6(1):43-43
      Background: Decreased high-energy phosphate level is involved in endothelial cell injury and dysfunction. Reduced telomerase activity in endothelial cells in parallel with reduced energy levels might be due to altered direction of alternative splicing machine as a complication of depleted energy during the process of atherosclerosis. Materials and Methods: Isolated human umbilical vein endothelial cells (HUVECs) were treated for 24 hours by oligomycine (OM) and 2-deoxy glucose (2-DG). After 24 hours, the effect of energy depletion on telomerase splicing pattern was evaluated using RT-PCR. Indeed, in both treated and untargeted cells, nitric oxide (NO) and von Willebrand factor (vWF) were measured. Results: ATP was depleted in treated cells by 43.9% compared with control group. We observed a slight decrease in NO levels (P = 0.09) and vWF (P = 0.395) in the setting of 49.36% ATP depletion. In both groups, no telomerase gene expression was seen. Telomerase and housekeeping gene expression were found in positive control group (colon cancer tissue) and sample tissue. Conclusions: The absence of telomerase gene expression in HUVECs might be due to the mortality of these cells or the low level of telomerase gene expression in these cells under normal circumstances.
      Citation: Advanced Biomedical Research 2017 6(1):43-43
      PubDate: Mon,17 Apr 2017
      DOI: 10.4103/2277-9175.204591
      Issue No: Vol. 6, No. 1 (2017)
       
  • The Prevalence of Osmophobia in Migranous and Episodic Tension Type
           Headaches

    • Authors: Ahmad Chitsaz, Abbas Ghorbani, Masoumeh Dashti, Mohsen Khosravi, Mohammadreza Kianmehr
      Pages: 44 - 44
      Abstract: Ahmad Chitsaz, Abbas Ghorbani, Masoumeh Dashti, Mohsen Khosravi, Mohammadreza Kianmehr
      Advanced Biomedical Research 2017 6(1):44-44
      Background: Migraines are a neurological disease, of which the most common symptom is an intense and disabling episodic headache. Many persons experience sensory hyper excitability manifested by photophobia, phonophobia and osmophobia. This study was planned to investigate the prevalence of osmophobia in migranous and episodic tension type headache (ETTH). Materials and Methods: A semi-structured questionnaire was administered to all patients to evaluate the eventual presence of osmophobia during a headache attack and different characteristics of osmophobia were determined. Results: Osmophobia reported in 84% with migranous headache with aura, 74% of migranous patients without aura and in 43.3% of those with ETTH. In 50% of patients, osmophobia was present in all of their headache attacks, 11.7% had osmophobia in more than half of their attacks (from 10 attacks they reported osmophobia in 5-9 ones) and others had this sign in less than half of their attacks (from 10 attacks they reported osmophobia in less than 5 ones). Most frequently the offending odors were scents (88%), foods (54.2%) and cigarette smoke (62.5%). Osmophobia starts 30 min before the headache starts in 22.7% of patients. Conclusion: Osmophobia appears structurally integrated into the migraine history of the patient; however, for differential diagnosis with ETTH, other criteria are necessary.
      Citation: Advanced Biomedical Research 2017 6(1):44-44
      PubDate: Mon,17 Apr 2017
      DOI: 10.4103/2277-9175.204587
      Issue No: Vol. 6, No. 1 (2017)
       
  • The Correlation between Different Risk Factors of Hepatitis C and
           Different Genotypes

    • Authors: Mozhgan Mokhtari, Hanieh Basirkazeruni, Mojtaba Rostami
      Pages: 45 - 45
      Abstract: Mozhgan Mokhtari, Hanieh Basirkazeruni, Mojtaba Rostami
      Advanced Biomedical Research 2017 6(1):45-45
      Background: Hepatitis C infection is one of the health problems in the world. Several known risk factors are responsible in transmission of this infection. We are going to study the prevalence of these risk factors for different genotypes of hepatitis C and if possible, specify probable relations between each risk factor and transmission of each genotype. Materials and Methods: This is a cross-sectional study done on 270 people who had positive anti-hepatitis C virus (HCV) antibody and HCV RNA. Demographic specificity and possible risk factors were collected using a questionnaire, and statistical analysis was done by SPSS software (version 20). Chi-square test used to estimate the prevalence and relation between each qualitative risk factor and HCV genotype transmitted. Analysis of variance was used for studying the prevalence and relation between quantitative risk factors and HCV genotypes. Results: The sample size was 270 persons. Of these, 217 (80.4%) were men and 185 (68.5%) were infected with genotype Type III. Most people were in age range of 31–40 years old 92 (34%). Single people were 126 (46.7%) and 169 (62.6%) were high school and university graduated. Tattooing as a risk factor had a meaningful relation with hepatitis C genotype (P < 0.001). Conclusions: According to the findings, most people in central provinces of Iran with hepatitis C are carrying genotype III, with most prevalent risk factors such as intravenous drug use and unsafe sexual activity. Besides, tattooing had a significant association with hepatitis C genotype, so that in these groups of people, genotype I was more frequent isolated virus.
      Citation: Advanced Biomedical Research 2017 6(1):45-45
      PubDate: Mon,17 Apr 2017
      DOI: 10.4103/2277-9175.204588
      Issue No: Vol. 6, No. 1 (2017)
       
  • Acute Subdural Hematoma and Subarachnoid Hemorrhage Caused by Ruptured
           Cortical Artery Aneurysm: Case Report and Review of Literature

    • Authors: Ahmad Shekarchizadeh, Saburi Masih, Pourkhalili Reza, Bahram Seif
      Pages: 46 - 46
      Abstract: Ahmad Shekarchizadeh, Saburi Masih, Pourkhalili Reza, Bahram Seif
      Advanced Biomedical Research 2017 6(1):46-46
      The present report describes an acute subdural hematoma (ASDH) associated with subarachnoid hemorrhage (SAH), due to ruptured cortical aneurysm. To our knowledge, extremely rare cases of this sort have been reported so far. A 23-year-old male patient without previous trauma presented with severe headache and rapidly decreasing level of consciousness to decerebrate status. Computed tomography (CT) scan has demonstrated an ASDH together with SAH. Hematoma has immediately been evacuated without any evaluation by angiography. After evacuation of the thick subdural clot, a 10-mm aneurysm was revealed on a precentral artery of frontal cortex, which was ligated. However, after 35 days the patient discharged with left side hemiparesis and dysphasia, and just after several months of admission he got symptom free. Ruptured cortical aneurysm should be considered as one of the causes of spontaneous ASDH. Vascular anomaly investigations are suggested for these cases, thus CT angiography or digital subtraction angiography has to be considered if clinical condition allows.
      Citation: Advanced Biomedical Research 2017 6(1):46-46
      PubDate: Mon,17 Apr 2017
      DOI: 10.4103/2277-9175.204589
      Issue No: Vol. 6, No. 1 (2017)
       
  • Prevalence of Nonalcoholic Fatty Liver Disease and its Related Metabolic
           Risk Factors in Isfahan, Iran

    • Authors: Atoosa Adibi, Shahab Maleki, Peyman Adibi, Reza Etminani, Silva Hovsepian
      Pages: 47 - 47
      Abstract: Atoosa Adibi, Shahab Maleki, Peyman Adibi, Reza Etminani, Silva Hovsepian
      Advanced Biomedical Research 2017 6(1):47-47
      Background: This study aimed to determine the prevalence of nonalcoholic fatty liver disease (NAFLD) and its related risk factors among the general population of Isfahan city located in the central part of Iran. Materials and Methods: In this cross-sectional study, the prevalence of NAFLD among 483 general adult populations was determined using ultrasonography. Anthropometric and biochemical variables were compared in groups with and without NAFLD and their predictive value for occurrence of NAFLD was investigated also. Results: Prevalence of NAFLD was 39.3%. Frequency of focal fatty infiltration (FFI), Grade I, Grade II, and Grade III of NAFLD was 9.5%, 21.1%, 7.2%, 1.4%, respectively. Prevalence of different types of NAFLD and FFI, was not different between female and male participants (P = 0.238). Ordinal regression was determined that all of the studied variables have significant predictive value for NAFLD (P < 0.001, γ = 0.615). Spearman correlation indicated that there was a significant relationship between NAFLD and BMI (r = 0.37, P< 0.001), age (r = 0.15, P = 0.001), FBS (r = 0.20, P< 0.001), cholesterol (r = 0.19, P< 0.001), triglyceride (r = 0.20, P< 0.001), LDL (r = 0.16, P< 0.001), AST (r = 0.17, P< 0.001), and ALT (r = 0.31, P< 0.001). Conclusions: Considering the high prevalence of NAFLD specially its lower grades among Isfahani adult general population and their association with studied variables, it seems that interventional studies which target-related mentioned risk factors could reduce the overall occurrence of NAFLD.
      Citation: Advanced Biomedical Research 2017 6(1):47-47
      PubDate: Mon,17 Apr 2017
      DOI: 10.4103/2277-9175.204590
      Issue No: Vol. 6, No. 1 (2017)
       
  • The Role of Fibular Fixation in the Treatment of Combined Distal Tibia and
           Fibula Fracture: A Randomized, Control Trial

    • Authors: Mohammad Javdan, Mohammad Ali Tahririan, Morteza Nouri
      Pages: 48 - 48
      Abstract: Mohammad Javdan, Mohammad Ali Tahririan, Morteza Nouri
      Advanced Biomedical Research 2017 6(1):48-48
      Background: This randomized, parallel-group, non-blinded study was designed to determine the role of fibular fixation in the treatment outcomes of combined distal tibia and fibula fractures. Materials and Methods: Sixty patients with distal tibial and fibular fractures were randomly divided in two groups of case and controls. In the case group, fibula was fixed prior to the fixation of tibia. In the control group, tibia was fixed without fibular fixation. Primary outcomes were varus–valgus angulation, anterior–posterior angulation, union and side effects. Follow-up visit and radiographs were taken 2 and 4 weeks as well as 3, 6 and 9 months after surgery. Results: During the follow-up, 11 out of 60 patients in case and control groups were excluded. We recruited 24 and 25 patients in the case and control group, respectively. Intramedullary nailing was used in 8 patients of case and 11 patients of control group. Plate and screw were used in 16 patients in the case and 14 patients in the control group. Varus/valgus and anterior–posterior angulation were not statistically significant between two groups (P ≥ 0.05). The frequency of tibial and fibula union after 1, 3, 6 and 9 months in case and controls groups were not statistically significant (P ≥ 0.05). The frequency of nonunion of tibia and fibula, infection and nerve injury in studied groups were not statistically significant (P ≥ 0.05). Conclusion: We did not observe any significant improvement using fibular fixation in the treatment outcomes of tibia distal fractures.
      Citation: Advanced Biomedical Research 2017 6(1):48-48
      PubDate: Tue,25 Apr 2017
      DOI: 10.4103/2277-9175.205190
      Issue No: Vol. 6, No. 1 (2017)
       
  • Phenotypic and Molecular Identification of Nocardia in Brain Abscess

    • Authors: Mehdi Fatahi-Bafghi
      Pages: 49 - 49
      Abstract: Mehdi Fatahi-Bafghi
      Advanced Biomedical Research 2017 6(1):49-49

      Citation: Advanced Biomedical Research 2017 6(1):49-49
      PubDate: Tue,25 Apr 2017
      DOI: 10.4103/2277-9175.205191
      Issue No: Vol. 6, No. 1 (2017)
       
  • Hypokalemia at the Time of Admission to the Intensive Care Unit (Icu)
           Increases the Need for Mechanical Ventilation and Time of Ventilation in
           Critically Ill Trauma Patients

    • Authors: Mohammadreza Safavi, Azim Honarmand, Mozhgan Karbalayi Mehrizi, Mansour Siavash Dastjerdi, Mohammad Emami Ardestani
      Pages: 50 - 50
      Abstract: Mohammadreza Safavi, Azim Honarmand, Mozhgan Karbalayi Mehrizi, Mansour Siavash Dastjerdi, Mohammad Emami Ardestani
      Advanced Biomedical Research 2017 6(1):50-50

      Citation: Advanced Biomedical Research 2017 6(1):50-50
      PubDate: Tue,25 Apr 2017
      DOI: 10.4103/2277-9175.205189
      Issue No: Vol. 6, No. 1 (2017)
       
  • The Predicting Ability of Serum Phosphorus to Assess the Duration of
           Mechanical Ventilation in Critically Ill Patients

    • Authors: Reihanak Talakoub, Mahshid Bahrami, Azim Honarmand, Saeed Abbasi, Hamideh Gerami
      Pages: 51 - 51
      Abstract: Reihanak Talakoub, Mahshid Bahrami, Azim Honarmand, Saeed Abbasi, Hamideh Gerami
      Advanced Biomedical Research 2017 6(1):51-51
      Background: No previous study exists to evaluate serum phosphorus (Ph) level as a predictor of the need to mechanical ventilation (MV). This study was designed to determine the predictive ability of admission serum Ph level on MV in patients admitted in Intensive Care Unit (ICU). Materials and Methods: This prospective study was conducted on 100 patients (>16 years old), admitted to our ICU over 1-year. Patients were classified into two groups according to the days of the need to MV. Group A: Patients who required equal or <5 days MV, and Group B: Patients who required more than 5 days of MV. We measured total serum Ph concentrations at the times of ICU admission, connecting to the ventilator and weaning from the ventilator. Results: There were significant differences between serum Ph concentration on admission to ICU (Group A: 3.39 ± 0.39 mg/dl, Group B: 2.89 ± 0.31 mg/dl, P < 0.001), at the time of connecting to ventilator (Group A: 2.49 ± 0.38 mg/dl, Group B: 2.25 ± 0.26 mg/dl, P = 0.004) and weaning from ventilator (Group A: 3.42 ± 0.33 mg/dl, Group B: 2.98 ± 0.34 mg/dl, P < 0.001) between two groups. Duration of ICU stay in Group A was 6.08 ± 1.48 days and in Group B was 15.35 ± 6.45, this difference was significant (P < 0.001). We found the best cut-off point of 3.07 for serum Ph concentration to predict the longer duration of MV.Conclusion: According to the results of our study, hypophosphatemia may increase the need to MV. Therefore, monitoring serum Ph level is a good prognostic factor to predict the need to ventilation.
      Citation: Advanced Biomedical Research 2017 6(1):51-51
      PubDate: Tue,25 Apr 2017
      DOI: 10.4103/2277-9175.205192
      Issue No: Vol. 6, No. 1 (2017)
       
  • The Comparison Effects of Two Methods of (Adaptive Support Ventilation
           Minute Ventilation: 110% and Adaptive Support Ventilation Minute
           Ventilation: 120%) on Mechanical Ventilation and Hemodynamic Changes and
           Length of being in Recovery in Intensive Care Units

    • Authors: Babak Ali Kiaei, Parviz Kashefi, Seyed Taghi Hashemi, Daryoush Moradi, Ahmad Mobasheri
      Pages: 52 - 52
      Abstract: Babak Ali Kiaei, Parviz Kashefi, Seyed Taghi Hashemi, Daryoush Moradi, Ahmad Mobasheri
      Advanced Biomedical Research 2017 6(1):52-52
      Background: The conventional method for ventilation is supported by accommodative or adaptive support ventilation (ASV) that the latter method is done with two methods: ASV minute ventilation (mv): 110% and ASV mv: 120%. Regarding these methods this study compared the differences in duration of mechanical ventilation and hemodynamic changes during recovery and length of stay in Intensive Care Units (ICU). Materials and Methods: In a clinical trial study, forty patients candidate for ventilation were selected and randomly divided into two groups of A and B. All patients were ventilated by Rafael ventilator. Ventilator parameters were set on ASV mv: 110% or ASV mv: 120% and patients were monitored on pulse oximetry, electrocardiography monitoring, central vein pressure and arterial pressure. Finally, the data entered to computer and analyzed by SPSS software. Results: The time average of connection to ventilator in two groups in modes of ASV mv: 110% and 120% was 12.3 ± 3.66 and 10.8 ± 2.07 days respectively, and according to t-test, there was no significant difference between two groups (P = 0.11). The average of length of stay in ICU in two groups of 110% and 120% was 16.35 ± 3.51 and 15.5 ± 2.62 days respectively, and according to t-test, there found to be no significant difference between two groups (P = 0.41). Conclusion: Using ASV mv: 120% can decrease extubation time compared with ASV mv: 110%. Furthermore, there is not a considerable side effect on hemodynamic of patients.
      Citation: Advanced Biomedical Research 2017 6(1):52-52
      PubDate: Tue,2 May 2017
      DOI: 10.4103/2277-9175.205526
      Issue No: Vol. 6, No. 1 (2017)
       
  • Insecticide Activity of Ageratina jahnii and Ageratina pichinchensis
           (Asteraceae) against Lutzomyia migonei (Diptera: Psychodidae)

    • Authors: Lizzeth Torres, Janne Rojas, Maritza Rond&#243;n, Antonio Morales, Elsa Nieves
      Pages: 53 - 53
      Abstract: Lizzeth Torres, Janne Rojas, Maritza Rondón, Antonio Morales, Elsa Nieves
      Advanced Biomedical Research 2017 6(1):53-53
      Background: Insects are mostly pathogens transmitters, thus the necessity of finding effective bioinsecticides to combat them. In the present investigation, the insecticide activity of Ageratina jahnii and Ageratina pichinchensis (Asteraceae) essential oils, methanol, and aqueous extracts was evaluated against Lutzomyia migonei (Diptera: Psychodidae) females, Leishmania transmitters, a wide distributed parasitosis in Latin America. Materials and Methods: All extracts were prepared by maceration at room temperature, and essential oils were obtained by hydrodistillation process. Females of L. migonei were used in the bioassays using the adulticide test in pots. Results: Essential oils from both assayed plant species showed 100% of L. migonei mortality at 48 h of exposure at the concentration of 10 mg/ml. A. jahnii essential oil exhibited the following values, LD50 = 0.39 mg/ml, LD90 = 1.57 mg/ml, LD95 = 2.31 mg/ml, and LD99 = 4.80 mg/ml while for A. pichinchensis essential oil values were LD50 = 0.31 mg/ml, LD90 = 0.99 mg/ml, LD95 = 1.38 mg/ml, and LD99 = 2.55 mg/ml. Conclusion: Higher toxicity was observed with A. pichinchensis essential oil against L. migonei, comparing to A. jahnii oil. Two new plant species are being reported, showing bioactive properties against common tropical disease vectors such as L. migonei, hence, opening possibilities to a more environmental friendly control.
      Citation: Advanced Biomedical Research 2017 6(1):53-53
      PubDate: Tue,2 May 2017
      DOI: 10.4103/2277-9175.205525
      Issue No: Vol. 6, No. 1 (2017)
       
  • Nosocomial Infections in Intensive Care Unit: Pattern of
           Antibiotic-resistance in Iranian Community

    • Authors: Bahram Nasr Esfahani, Rozita Basiri, Seyed Mohammad Mahdy Mirhosseini, Sharareh Moghim, Shahaboddin Dolatkhah
      Pages: 54 - 54
      Abstract: Bahram Nasr Esfahani, Rozita Basiri, Seyed Mohammad Mahdy Mirhosseini, Sharareh Moghim, Shahaboddin Dolatkhah
      Advanced Biomedical Research 2017 6(1):54-54
      Background: Bacterial infections are responsible for great number of mortality in Intensive Care Unit (ICU). Knowledge about prevalence of bacterial infections and their antibiotic-resistance pattern would be a great step for their treatment and management. Materials and Methods: Data about nosocomial infections in ICUs of Alzahra Hospital (referral hospital in Isfahan, center of Iran) were gathered during the years 2007–2010. A questionnaire was fulfilled for any specific patient with nosocomial infection containing demographic data of patient and also characteristics of the infection. Results: Out of all patients, 707 individuals (65.6%) were male and 370 (34.4%) were female. Our data revealed that Pseudomonas aeruginosa (13.9%), Klebsiella (11%), and Escherichia coli (6.4%) were the most prevalent bacterial infections. The most common sites of nosocomial infections in the ICU were respiratory system (399 cases, 37%), urinary system (230 cases, 21.4%), and blood (102 cases, 9.5%). The antibiotic-resistance of each bacteria in ICU ward was assessed and data were categorized in a table. There were less documentary about bacterial cultures in the year 2007 when compared with the next years. Conclusion: We found some differences (such as bacterial prevalence in ICU wards which caused nosocomial infections) in our local prevalence of nosocomial infections and also in their resistance pattern compared to other centers. Knowing about our data will help physicians to administer the most suitable antibiotics for treatment of nosocomial infections in our area.
      Citation: Advanced Biomedical Research 2017 6(1):54-54
      PubDate: Tue,2 May 2017
      DOI: 10.4103/2277-9175.205527
      Issue No: Vol. 6, No. 1 (2017)
       
  • The Comparison between Effects of 12 weeks Combined Training and Vitamin D
           Supplement on Improvement of Sensory-motor Neuropathy in type 2 Diabetic
           Women

    • Authors: Maryam Nadi, Seyyed Mohammad Marandi, Fahimeh Esfarjani, Mohammad Saleki, Mahboobeh Mohammadi
      Pages: 55 - 55
      Abstract: Maryam Nadi, Seyyed Mohammad Marandi, Fahimeh Esfarjani, Mohammad Saleki, Mahboobeh Mohammadi
      Advanced Biomedical Research 2017 6(1):55-55
      Background: Peripheral neuropathy is a common complaint of diabetes. This study aimed to determine the effects of 12 weeks combined training with Vitamin D supplement on improvement of sensory-motor neuropathy in women with diabetic neuropathy. Materials and Methods: This clinical trial study conducted on 90 patients were selected and randomly divided into two groups. Finally, 81 adult females with diabetes type II (20–55 years old) were interred in this study. The control group had no training, but received Vitamin D. The experimental group received Vitamin D and 12 weeks training program (3 days a week, 60 min/session) including aerobic exercises, strength, and flexibility. Aerobic exercise intensity was set at 60–70% maximum heart rate and resistance training intensity was determined by 10 R.M. Michigan neuropathy questionnaire, reflex hammer and tuning fork 128 Hz used to screening tense of neuropathy (Michigan Neuropathy Screening Instrument) that were used for pretest and posttest. Results: Following 3 months combined training and supplementation with Vitamin D, had observed a significant reduction in numbness (P = 0.001), pain (0.002), tingling (P = 0.001), and weakness (P = 0.002) in the lower limb and also increases in sense of touch intervention (P = 0.005), detects the position of the fingers (P = 0.001) and vibration perception (P = 0.001) in tissues. Knee reflexes (P = 0.77) and ankles reflexes (P = 0.47) did not significantly change after interventions. Conclusion: It seems that taking part in combined training and supplementation with Vitamin D can improve the symptoms of sensory-motor neuropathy.
      Citation: Advanced Biomedical Research 2017 6(1):55-55
      PubDate: Tue,2 May 2017
      DOI: 10.4103/2277-9175.205528
      Issue No: Vol. 6, No. 1 (2017)
       
  • EPCAM Expression in Colon Adenocarcinoma and its Relationship with TNM
           Staging

    • Authors: Mojhgan Mokhtari, Zeinab Zakerzade
      Pages: 56 - 56
      Abstract: Mojhgan Mokhtari, Zeinab Zakerzade
      Advanced Biomedical Research 2017 6(1):56-56
      Background: Since epithelial cell adhesion molecule glycoprotein (EPCAM) is associated with the development and metastasis of colon adenocarcinoma, it can be helpful in predicting the tumor stage before surgery. In this study, we investigated EPCAM glycoprotein expression in colon adenocarcinoma and its relationship with tumor staging. Materials and Methods: This study was done on formalin-fixed and paraffin-embedded tissues of 71 patients diagnosed with colon adenocarcinoma, together with normal tissues around them, which were available at the archive of pathology lab of Al-Zahra hospital, Isfahan. Hematoxylin and eosin (HandE) and immunohistochemistry (IHC) staining methods for EPCAM marker were performed on paraffin-embedded blocks. Results: The percentage of staining of EPCAM glycoprotein in the tumoral and normal tissues of 71 patients with colon adenocarcinoma was studied and compared. In normal tissue, 84.5% showed strong staining, 15.5% showed moderate to strong, and none of the patients showed moderate, weak, or no staining at all. In the tumoral tissue, 25.4% had strong, 25.4% had moderate to strong, 26.8% showed moderate, 16.9% showed weak and 5.6% had no staining at all. EPCAM expression was significantly less in tumoral tissue than in normal. Conclusion: There was an inverse relationship between tumor staging and the percentage of staining in EPCAM glycoprotein so this marker can be used for predicting the tumor stage.
      Citation: Advanced Biomedical Research 2017 6(1):56-56
      PubDate: Tue,2 May 2017
      DOI: 10.4103/2277-9175.205529
      Issue No: Vol. 6, No. 1 (2017)
       
  • Erratum: Assessment of a 2D Electronic Portal Imaging Devices-based
           Dosimetry Algorithm for Pretreatment and In-vivo Midplane Dose
           Verification

    • Pages: 57 - 57
      Abstract:
      Advanced Biomedical Research 2017 6(1):57-57

      Citation: Advanced Biomedical Research 2017 6(1):57-57
      PubDate: Thu,11 May 2017
      DOI: 10.4103/2277-9175.206109
      Issue No: Vol. 6, No. 1 (2017)
       
 
 
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