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Publisher: Medknow Publishers   (Total: 355 journals)

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Showing 1 - 200 of 355 Journals sorted alphabetically
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advances in Human Biology     Open Access   (Followers: 1)
African J. for Infertility and Assisted Conception     Open Access  
African J. of Business Ethics     Open Access   (Followers: 6)
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.269, h-index: 10)
African J. of Trauma     Open Access  
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 6)
Anesthesia : Essays and Researches     Open Access   (Followers: 8)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.331, h-index: 15)
Annals of Bioanthropology     Open Access   (Followers: 3)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.408, h-index: 15)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.308, h-index: 14)
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 7, SJR: 0.441, h-index: 10)
Annals of Saudi Medicine     Open Access   (SJR: 0.24, h-index: 29)
Annals of Thoracic Medicine     Open Access   (Followers: 4, SJR: 0.388, h-index: 19)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 15, SJR: 0.148, h-index: 5)
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Intl. Surgery     Open Access   (Followers: 9)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Pharmacy Practice     Open Access   (Followers: 6)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 3)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.879, h-index: 49)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 2, SJR: 0.362, h-index: 10)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Cancer Translational Medicine     Open Access   (Followers: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 1)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access   (Followers: 1)
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 12, SJR: 0.82, h-index: 12)
Contemporary Clinical Dentistry     Open Access   (Followers: 4)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.339, h-index: 19)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.131, h-index: 4)
Dental Research J.     Open Access   (Followers: 9)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 5, SJR: 0.205, h-index: 22)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access  
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.121, h-index: 3)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Orthopaedic J.     Open Access  
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.473, h-index: 8)
Environmental Disease     Open Access   (Followers: 2)
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.496, h-index: 11)
European J. of General Dentistry     Open Access   (Followers: 1)
European J. of Prosthodontics     Open Access   (Followers: 2)
European J. of Psychology and Educational Studies     Open Access   (Followers: 8)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.107, h-index: 5)
Genome Integrity     Open Access   (Followers: 4, SJR: 1.227, h-index: 12)
Global J. of Transfusion Medicine     Open Access   (Followers: 2)
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
IJS Short Reports     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 8, SJR: 0.302, h-index: 13)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (SJR: 0.318, h-index: 26)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.618, h-index: 16)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.307, h-index: 16)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.243, h-index: 24)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.448, h-index: 16)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 3, SJR: 0.563, h-index: 29)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.292, h-index: 9)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.53, h-index: 34)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.716, h-index: 60)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.207, h-index: 31)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.233, h-index: 12)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.213, h-index: 5)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 4, SJR: 0.203, h-index: 13)
Indian J. of Ophthalmology     Open Access   (Followers: 5, SJR: 0.536, h-index: 34)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 9, SJR: 0.393, h-index: 15)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.218, h-index: 5)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.35, h-index: 12)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 1, SJR: 0.285, h-index: 22)
Indian J. of Pharmacology     Open Access   (SJR: 0.347, h-index: 44)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.303, h-index: 13)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.496, h-index: 15)
Indian J. of Psychological Medicine     Open Access   (Followers: 1, SJR: 0.344, h-index: 9)
Indian J. of Public Health     Open Access   (Followers: 1, SJR: 0.444, h-index: 17)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4, SJR: 0.253, h-index: 14)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.169, h-index: 7)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.313, h-index: 9)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.366, h-index: 16)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 4, SJR: 0.229, h-index: 13)
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 7)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.239, h-index: 4)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.523, h-index: 15)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 7, SJR: 0.611, h-index: 9)
Intl. J. of Trichology     Open Access   (SJR: 0.37, h-index: 10)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 3)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 4, SJR: 0.427, h-index: 15)
J. of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 8, SJR: 0.416, h-index: 14)
J. of Applied Hematology     Open Access  
J. of Association of Chest Physicians     Open Access   (Followers: 2)
J. of Basic and Clinical Reproductive Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Therapeutics     Open Access   (Followers: 4, SJR: 0.359, h-index: 21)
J. of Carcinogenesis     Open Access   (Followers: 1, SJR: 1.152, h-index: 26)
J. of Cardiothoracic Trauma     Open Access  
J. of Cardiovascular Disease Research     Open Access   (Followers: 3, SJR: 0.351, h-index: 13)
J. of Cardiovascular Echography     Open Access   (SJR: 0.134, h-index: 2)
J. of Cleft Lip Palate and Craniofacial Anomalies     Open Access   (Followers: 2)
J. of Clinical and Preventive Cardiology     Open Access   (Followers: 1)
J. of Clinical Imaging Science     Open Access   (Followers: 1, SJR: 0.277, h-index: 8)
J. of Clinical Neonatology     Open Access   (Followers: 1)
J. of Clinical Ophthalmology and Research     Open Access   (Followers: 2)
J. of Clinical Sciences     Open Access  
J. of Conservative Dentistry     Open Access   (Followers: 4, SJR: 0.532, h-index: 10)
J. of Craniovertebral Junction and Spine     Open Access   (Followers: 4, SJR: 0.199, h-index: 9)
J. of Current Medical Research and Practice     Open Access  
J. of Current Research in Scientific Medicine     Open Access  
J. of Cutaneous and Aesthetic Surgery     Open Access   (Followers: 1)
J. of Cytology     Open Access   (Followers: 1, SJR: 0.274, h-index: 9)
J. of Dental and Allied Sciences     Open Access   (Followers: 1)
J. of Dental Implants     Open Access   (Followers: 7)
J. of Dental Lasers     Open Access   (Followers: 2)
J. of Dental Research and Review     Open Access   (Followers: 1)
J. of Digestive Endoscopy     Open Access   (Followers: 3)
J. of Dr. NTR University of Health Sciences     Open Access  
J. of Earth, Environment and Health Sciences     Open Access   (Followers: 1)
J. of Education and Ethics in Dentistry     Open Access   (Followers: 5)
J. of Education and Health Promotion     Open Access   (Followers: 5)
J. of Emergencies, Trauma and Shock     Open Access   (Followers: 9, SJR: 0.353, h-index: 14)
J. of Engineering and Technology     Open Access   (Followers: 6)
J. of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
J. of Family and Community Medicine     Open Access   (Followers: 2)
J. of Family Medicine and Primary Care     Open Access   (Followers: 11)

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Journal Cover International Journal of Clinical and Experimental Physiology
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  This is an Open Access Journal Open Access journal
   ISSN (Print) 2348-8832 - ISSN (Online) 2348-8093
   Published by Medknow Publishers Homepage  [355 journals]
  • Dietary cholesterol restriction is not good for health

    • Authors: Gopal Krushna Pal, Nivedita Nanda
      Pages: 109 - 110
      Abstract: Gopal Krushna Pal, Nivedita Nanda
      International Journal of Clinical and Experimental Physiology 2017 4(3):109-110

      Citation: International Journal of Clinical and Experimental Physiology 2017 4(3):109-110
      PubDate: Mon,16 Oct 2017
      DOI: 10.4103/ijcep.ijcep_48_17
      Issue No: Vol. 4, No. 3 (2017)
       
  • Potassium homeostasis, oxidative stress, and human disease

    • Authors: Udensi K Udensi, Paul B Tchounwou
      Pages: 111 - 122
      Abstract: Udensi K Udensi, Paul B Tchounwou
      International Journal of Clinical and Experimental Physiology 2017 4(3):111-122
      Potassium is the most abundant cation in the intracellular fluid, and it plays a vital role in the maintenance of normal cell functions. Thus, potassium homeostasis across the cell membrane is very critical because a tilt in this balance can result in different diseases that could be life-threatening. Both oxidative stress (OS) and potassium imbalance can cause significant adverse health conditions. OS and abnormalities in potassium channel have been reported in neurodegenerative diseases. This review highlights the major factors involved in potassium homeostasis (dietary, hormonal, genetic, and physiologic influences), and discusses the major diseases and abnormalities associated with potassium imbalance including hypokalemia, hyperkalemia, hypertension, chronic kidney disease, and Gordon's syndrome, Bartter syndrome, and Gitelman syndrome.
      Citation: International Journal of Clinical and Experimental Physiology 2017 4(3):111-122
      PubDate: Mon,16 Oct 2017
      DOI: 10.4103/ijcep.ijcep_43_17
      Issue No: Vol. 4, No. 3 (2017)
       
  • Placebo response in clinical trials: Taming the human brain

    • Authors: Payal Bhardwaj, Raj Kumar Yadav
      Pages: 123 - 128
      Abstract: Payal Bhardwaj, Raj Kumar Yadav
      International Journal of Clinical and Experimental Physiology 2017 4(3):123-128
      The use of placebo in comparative clinical trials has exposed another lesser known side of the placebo, i.e., the placebo response. The placebo response is now being increasingly discussed, not only to adjust for the true clinical efficacy of a drug but also to understand the basis of psychological therapy, and benefits in therapeutic areas such as neurological disorders, especially pain. The mechanism of placebo action is multifaceted and works on the levels of brain and biochemical signaling, stimulated by priming and expectations. The imaging data show that certain areas of the brain are hyperactive while some are hypoactive during the placebo-mediated response, and trigger a biochemical pathway that relieves the symptoms. The data also suggest that the extent of benefit, i.e., the effect size of placebo response is directly proportional to positive expectations associated with the treatment, trust on the treating doctor, and certain beliefs associated with previous treatment. Although placebos incite a positive response, these might compromise or artifact the true efficacy of the drugs, thereby necessitating the need of addressing or minimizing the placebo response. Furthermore, it is important to identify the factors that modulate the placebo response, such as severity and natural burning out of the disease. Therefore, it is important to take a two-pronged approach- first, placebo as a treatment, for example, in neurological diseases, and second, adequately designed studies that minimize the placebo response. In this article, we discuss the placebo response, the mechanism behind it, its implications in clinical trials, and how to address the same.
      Citation: International Journal of Clinical and Experimental Physiology 2017 4(3):123-128
      PubDate: Mon,16 Oct 2017
      DOI: 10.4103/ijcep.ijcep_36_17
      Issue No: Vol. 4, No. 3 (2017)
       
  • Sokolow-Lyon voltage and cornell voltage criteria in the diagnosis of left
           ventricular hypertrophy in obese individuals

    • Authors: Samata Padaki, Amrut Dambal
      Pages: 129 - 132
      Abstract: Samata Padaki, Amrut Dambal
      International Journal of Clinical and Experimental Physiology 2017 4(3):129-132
      Background and Aim: Left ventricular hypertrophy (LVH) marks the ongoing disease process involving the heart. A precise diagnostic tool needs to be established to accurately determine LVH by electrocardiography (ECG), which itself is a predictor of future cardiovascular mortality and morbidity. Assessment of LVH electrocardiographically by Sokolow-Lyon voltage criteria and Cornell voltage criteria in obese individuals. Methods: Obese 50 individuals with LVH secondary to hypertension confirmed by echocardiogram were considered as study subjects. Standard 12-lead ECG was obtained and analyzed for Sokolow-Lyon voltage criteria and Cornell voltage criteria. Statistical analysis was done by unpaired t-test using SPSS package version 20. Results: According to Sokolow-Lyon voltage criteria, 42 cases (38.27 ± 2.96) and 41 controls (37.23 ± 2.01) had LVH which was statistically nonsignificant. According to Cornell voltage criteria, 36 male cases (35.42 ± 2.98) and 36 controls (32.3 ± 2.13) had LVH and it was statistically significant (P < 0.000 1). Ten female cases (26.87 ± 2.01) and 7 controls (22.9 ± 2.36) also had LVH and it was statistically significant (P < 0.002). About 84% of cases were assessed to have LVH by Sokolow-Lyon voltage criteria whereas 92% of cases were assessed to have LVH by Cornell voltage criteria. Conclusion: QRS duration is an independent ECG predictor of the presence of LVH. The Cornell voltage criteria significantly improve identification of LVH relative to Sokolow-Lyon voltage criteria in obese individuals.
      Citation: International Journal of Clinical and Experimental Physiology 2017 4(3):129-132
      PubDate: Mon,16 Oct 2017
      DOI: 10.4103/ijcep.ijcep_29_17
      Issue No: Vol. 4, No. 3 (2017)
       
  • Efficacy of Selective Phenolic Compounds on the Activity of Voltage-gated
           K+ Current in Human Prostate Cancer Cell Line

    • Authors: Kiran George, Raman Malathi
      Pages: 133 - 138
      Abstract: Kiran George, Raman Malathi
      International Journal of Clinical and Experimental Physiology 2017 4(3):133-138
      Background and Aim: Phenolic compounds are reported to possess wide range of therapeutic properties against variety of diseases including cancer. Voltage-gated K+ channels (IK) are known to contribute many basic cellular functions in cancer cells. However, only few studies describe the IKcurrent blockade and inhibition of cancer cell growth in prostate cancer cells. To investigate the electrophysiological characteristics of IKchannels in prostate cancer cells. Methods: In the present study, whole-cell patch-clamp technique is used to study the modulatory effect of curcumin, rutin, troxerutin, and resveratrol on IKcurrent in human prostate cancer cell line PC-3. Results: The obtained results show that exposure of PC-3 cells to 200 μM of resveratrol inhibited IKcurrent more than half of the current when compared to control. However, this effect was reversible after application of external solution. Whereas curcumin, rutin, and troxerutin did not show any effect on IKcurrent in PC-3 cells. Conclusion: Our findings reveal that among the various tested compounds, only resveratrol effectively inhibited IK current in PC-3 cells and also this study concludes that not all the anticancer compounds have the ability to inhibit IK current in PC-3 cells.
      Citation: International Journal of Clinical and Experimental Physiology 2017 4(3):133-138
      PubDate: Mon,16 Oct 2017
      DOI: 10.4103/ijcep.ijcep_39_17
      Issue No: Vol. 4, No. 3 (2017)
       
  • Relevancy of free online software and websites in detection of plagiarism

    • Authors: Himel Mondal, Shaikat Mondal
      Pages: 139 - 141
      Abstract: Himel Mondal, Shaikat Mondal
      International Journal of Clinical and Experimental Physiology 2017 4(3):139-141
      Background and Aim: Plagiarism is disgraceful to authors and opposed in the scientific community. Before submitting articles to journals, authors should check whether the article is unintentionally plagiarized or not. However, online premium plagiarism checking service may not be accessible to many authors. For those authors, there are many websites which offer plagiarism detection service free of cost. The aim of the study was to assess the efficacy of those websites in the detection of plagiarism. Methods: A paragraph of text with 2 verbatim plagiarized sentences, 2 inadequately paraphrased sentences, and 2 perceived unique sentences was used as a tool. This paragraph was checked for plagiarism in 23 popular websites. Results showed by websites were recorded and analyzed. Chi-square test with α = 0.05 was used to compare the proportion of websites. Results: Among 23 websites, only 4 websites (17.39%) detected plagiarism above the expected level. Thirteen (56.52%) websites showed result of 0% plagiarism for the paragraph. Verbatim plagiarism was detected by 6 websites (26.09%) where only 1 website could detect inadequate paraphrasing. Conclusion: The majority of websites offering free plagiarism checking service failed to detect plagiarized content effectively. The level of detected plagiarism differs in the different website for same content. Hence, checking the manuscript in multiple websites would provide relatively better screening result for plagiarism.
      Citation: International Journal of Clinical and Experimental Physiology 2017 4(3):139-141
      PubDate: Mon,16 Oct 2017
      DOI: 10.4103/ijcep.ijcep_38_17
      Issue No: Vol. 4, No. 3 (2017)
       
  • Increased cardiovascular risks in prehypertensives expressing
           angiotensin-converting enzyme gene polymorphism

    • Authors: Gopal Krushna Pal, Chandrasekaran Adithan, Pravati Pal, Nivedita Nanda, Allampalli Sirisha
      Pages: 142 - 147
      Abstract: Gopal Krushna Pal, Chandrasekaran Adithan, Pravati Pal, Nivedita Nanda, Allampalli Sirisha
      International Journal of Clinical and Experimental Physiology 2017 4(3):142-147
      Background and Aim: Although angiotensin-converting enzyme (ACE) gene polymorphism has been documented to play an important role in the genesis of hypertension, its role in the development of prehypertension has not been investigated. To study the association of ACE genotypes and their link to SVI and CV risks in young prehypertensives in Indian population. Methods: This cross-sectional study was conducted in 172 individuals divided into prehypertensives (n = 57) and normotensives (n = 115) based on their level of systolic blood pressure (SBP) and diastolic blood pressure (DBP). Body mass index, cardiovascular (CV) parameters such as heart rate (HR), SBP, DBP, mean arterial pressure (MAP), rate pressure product, stroke volume, left ventricular ejection time, cardiac output, total peripheral resistance, and baroreflex sensitivity (BRS) were recorded by continuous BP variability (BPV) monitoring using finapres, and sympathovagal imbalance (SVI) was assessed by spectral analysis of HR variability (HRV). Biochemical parameters such as homeostatic model assessment of insulin resistance (HOMA-IR), lipid risk factors, inflammatory markers, renin and oxidative stress (OS) parameters were measured. Genotyping for ACE gene polymorphism (insertion [I]/deletion [D] or ID polymorphism) was done by polymerase chain reaction-restriction fragment length polymorphism methods. Multiple regression analysis was done to assess the association between SVI and metabolic markers, and logistic regression was done to determine the BRS prediction of prehypertension status and CV risks in ACE genotypes. The BPV, HRV, and biochemical parameters were significantly altered in prehypertensives. Results: The ID genotype of ACE was most commonly distributed among the population (33.3% prehypertensives and 50.4% in normotensives). LH-HF ratio, the marker of SVI, was significantly associated with MAP, HOMA-IR, interleukin-6, tumor necrosis factor-alpha, renin, and BRS in ID genotype of prehypertensive population. BRS, the marker of CV risk, had significant prediction of prehypertension status in ID genotypes population. Conclusion: The ACE ID gene polymorphism appears to be the candidate gene for prehypertension. ID contributes to SVI in young prehypertensives attributed by insulin resistance and inflammation. The CV risks are strongly associated with prehypertension status in ID genotypes in prehypertensives.
      Citation: International Journal of Clinical and Experimental Physiology 2017 4(3):142-147
      PubDate: Mon,16 Oct 2017
      DOI: 10.4103/ijcep.ijcep_44_17
      Issue No: Vol. 4, No. 3 (2017)
       
  • A comparative study of glomerular filtration rate in normal healthy
           controls and type 2 diabetes mellitus patients in south India

    • Authors: Neelkanth Kote, MD Ranganath
      Pages: 148 - 151
      Abstract: Neelkanth Kote, MD Ranganath
      International Journal of Clinical and Experimental Physiology 2017 4(3):148-151
      Background and Aim: Diabetes mellitus (DM) is one of the most common metabolic diseases, which is characterized by increased blood glucose levels. DM is the leading cause for chronic kidney disease (CKD) and end-stage renal disease. To estimate the glomerular filtration rate (GFR) of normal healthy controls and type II DM (T2DM) patients using Cockcroft–Gault (CG) formula and to compare the GFR values of normal subjects and T2DM patients (with respect to glycated hemoglobin [HbA1c]). Methods: The total sample size of the study was 60, among which 30 were healthy individuals (controls) and 30 were T2DM patients (subjects with both controlled and uncontrolled HbA1c). A detailed history was taken from the subjects and controls followed by a thorough clinical examination. Blood and urine samples were collected from all the subjects for the estimation of serum creatinine, HbA1c, and urine routine analysis. The GFR is calculated for all the study participants using CG formula, and the results were expressed in the form of graphs and charts. Results: The overall GFR value was well within the normal limits in controls than the subjects. In the present study, the values of GFR were 106.87 + 8.29 and 100.03 + 12.42 in normal healthy controls (Group A) and diabetic subjects (Group B), respectively. In this study, value of HbA1c in healthy control males and females was 6.74 ± 0.39 and6.76 ± 1.04, respectively. Similarly, the value of HbA1c in diabetic subject males and females was 7.32 ± 0.69 and 7.06 ± 1.45, respectively. There was a significant positive correlation between GFR with the degree glycemic control in T2DM of the study population. Conclusion: The present study indicates that the degree of glycemic control in T2DM reflects the ongoing kidney damage by change in GFR of the kidney. The GFR of diabetic subjects is comparatively lower when compared with GFR of normal healthy controls. Our study also shows that there is a higher risk of developing CKD in diabetics with poor glycemic index than diabetics with good glycemic index.
      Citation: International Journal of Clinical and Experimental Physiology 2017 4(3):148-151
      PubDate: Mon,16 Oct 2017
      DOI: 10.4103/ijcep.ijcep_30_17
      Issue No: Vol. 4, No. 3 (2017)
       
  • Neurophysiological and audiological assessment in at-risk infants by
           brainstem evoked response audiometry in Haryana

    • Authors: Divya P Wangoo
      Pages: 152 - 156
      Abstract: Divya P Wangoo
      International Journal of Clinical and Experimental Physiology 2017 4(3):152-156
      Background and Aim: Sensorineural hearing loss is a serious neurodevelopmental sequel among high-risk neonates and is one of the most common congenital disorders. To assess the neurophysiological and audiological impairment in at-risk infants in Haryana. Methods: This was a time-bound study of 12 months duration during which 101 at-risk infants visiting SGT Hospital, Haryana, were enrolled for the study. Brainstem evoked response audiometry (BERA) findings in these children were analyzed. Methodology standardized by IFCN Committee and instrument Neurostim NS-2 of Medicaid firm were employed. 10–20 International System of EEG Electrode Placement was used for scalp electrode placement. The data were analyzed using the Statistical Software Package for the Social Sciences version 20. Results: Highly significant prolongation of various latencies and interpeak latencies (IPLs) was observed in the cases. Conclusion: Risk factors known to cause hearing loss affect BERA parameters causing highly significant prolongation of latencies and IPLs, suggesting that at-risk infants are prone to sensorineural hearing loss. Universal newborn hearing screening by BERA can be carried out in children, especially when they come for routine immunization. BERA is the only test that gives precise information about hearing sensitivity in children, especially <1 year of age.
      Citation: International Journal of Clinical and Experimental Physiology 2017 4(3):152-156
      PubDate: Mon,16 Oct 2017
      DOI: 10.4103/ijcep.ijcep_40_17
      Issue No: Vol. 4, No. 3 (2017)
       
  • Coexistence of epidermal growth factor receptor 19 deletion and 21 point
           mutation in nonsmall cell lung cancer: A report of 3 cases

    • Authors: Lu Yunyun
      Pages: 157 - 159
      Abstract: Lu Yunyun
      International Journal of Clinical and Experimental Physiology 2017 4(3):157-159
      The coexistence of an epidermal growth factor receptor (EGFR) 19 deletion and 21 point mutation represents a rare event in patients with nonsmall cell lung cancer. We present three cases of female patients with lung adenocarcinoma who had the double genetic mutations. The patients were all treated with EGFR tyrosine kinase inhibitors (TKIs) because the tumors were judged inoperable. In all cases, tumor progression occurred after a few months. Further studies are needed to determine whether the EGFR-TKI resistance time in patients with double genetic mutations is longer than that in patients with a single mutation.
      Citation: International Journal of Clinical and Experimental Physiology 2017 4(3):157-159
      PubDate: Mon,16 Oct 2017
      DOI: 10.4103/ijcep.ijcep_32_17
      Issue No: Vol. 4, No. 3 (2017)
       
  • News and Views

    • Authors: Pravati Pal
      Pages: 160 - 161
      Abstract: Pravati Pal
      International Journal of Clinical and Experimental Physiology 2017 4(3):160-161

      Citation: International Journal of Clinical and Experimental Physiology 2017 4(3):160-161
      PubDate: Mon,16 Oct 2017
      Issue No: Vol. 4, No. 3 (2017)
       
 
 
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