Publisher: Medknow Publishers   (Total: 420 journals)

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Showing 1 - 200 of 420 Journals sorted alphabetically
Acta Medica Intl.     Open Access   (SJR: 0.101, CiteScore: 0)
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access   (Followers: 1)
Advanced Biomedical Research     Open Access  
Advances in Human Biology     Open Access   (Followers: 5)
Advances in Skeletal Muscle Function Assessment     Open Access  
African J. for Infertility and Assisted Conception     Open Access   (Followers: 1)
African J. of Medical and Health Sciences     Open Access   (Followers: 4)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.25, CiteScore: 1)
African J. of Trauma     Open Access   (Followers: 1)
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access   (Followers: 2)
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Alexandria J. of Pediatrics     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 6)
Anesthesia : Essays and Researches     Open Access   (Followers: 11)
Annals of African Medicine     Open Access   (Followers: 2, SJR: 0.258, CiteScore: 1)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 15, SJR: 0.308, CiteScore: 1)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery     Open Access  
Annals of Indian Psychiatry     Open Access  
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 9)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 13, SJR: 0.352, CiteScore: 1)
Annals of Saudi Medicine     Open Access   (SJR: 0.238, CiteScore: 1)
Annals of Thoracic Medicine     Open Access   (Followers: 6, SJR: 0.524, CiteScore: 1)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 15, SJR: 0.152, CiteScore: 0)
Annals of Tropical Pathology     Open Access  
Apollo Medicine     Open Access  
APOS Trends in Orthodontics     Open Access   (Followers: 2)
Arab J. of Interventional Radiology     Open Access   (Followers: 1)
Archives of Cardiovascular Imaging     Open Access   (Followers: 2, SJR: 0.187, CiteScore: 0)
Archives of Intl. Surgery     Open Access   (Followers: 10, SJR: 0.302, CiteScore: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 5)
Archives of Medicine and Surgery     Open Access   (Followers: 1)
Archives of Pharmacy Practice     Open Access   (Followers: 12, SJR: 0.102, CiteScore: 0)
Archives of Trauma Research     Open Access   (Followers: 6, SJR: 0.37, CiteScore: 2)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access   (Followers: 1)
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 5)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.856, CiteScore: 2)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.35, CiteScore: 1)
Asian Pacific J. of Reproduction     Open Access   (Followers: 1, SJR: 0.227, CiteScore: 1)
Asian Pacific J. of Tropical Biomedicine     Open Access   (Followers: 2, SJR: 0.491, CiteScore: 2)
Asian Pacific J. of Tropical Medicine     Open Access   (Followers: 1, SJR: 0.561, CiteScore: 2)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
Biomedical and Biotechnology Research J.     Open Access   (Followers: 1)
Biomedical Research J.     Open Access   (Followers: 3)
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access   (Followers: 1)
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 2)
Canadian J. of Rural Medicine     Full-text available via subscription   (Followers: 1, SJR: 0.202, CiteScore: 0)
Cancer Translational Medicine     Open Access   (Followers: 2)
Cardiology Plus     Open Access   (Followers: 1)
Chinese Medical J.     Open Access   (Followers: 10, SJR: 0.52, CiteScore: 1)
CHRISMED J. of Health and Research     Open Access   (Followers: 2)
Clinical Cancer Investigation J.     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 5)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access   (Followers: 1)
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 11, SJR: 0.811, CiteScore: 2)
Contemporary Clinical Dentistry     Open Access   (Followers: 5, SJR: 0.353, CiteScore: 1)
Current Medical Issues     Open Access   (Followers: 2)
CytoJ.     Open Access   (Followers: 3, SJR: 0.543, CiteScore: 1)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 5, SJR: 0.152, CiteScore: 0)
Dental Research J.     Open Access   (Followers: 14, SJR: 0.416, CiteScore: 1)
Dentistry and Medical Research     Open Access   (Followers: 1)
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 9, SJR: 0.242, CiteScore: 0)
Education in the Health Professions     Open Access   (Followers: 2)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1, SJR: 1.799, CiteScore: 2)
Egyptian J. of Chest Diseases and Tuberculosis     Open Access   (Followers: 3, SJR: 0.155, CiteScore: 0)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 1)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Nursing J.     Open Access  
Egyptian Orthopaedic J.     Open Access   (Followers: 2)
Egyptian Pharmaceutical J.     Open Access   (Followers: 3)
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access   (Followers: 2)
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.822, CiteScore: 2)
Environmental Disease     Open Access   (Followers: 4)
Eurasian J. of Pulmonology     Open Access  
European J. of Dentistry     Open Access   (Followers: 4, SJR: 0.749, CiteScore: 2)
European J. of General Dentistry     Open Access   (Followers: 3, SJR: 0.12, CiteScore: 0)
European J. of Psychology and Educational Studies     Open Access   (Followers: 11, SJR: 0.113, CiteScore: 0)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.112, CiteScore: 0)
Genome Integrity     Open Access   (Followers: 2, SJR: 0.153, CiteScore: 0)
Glioma     Open Access  
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Gynecology and Minimally Invasive Therapy     Open Access   (SJR: 0.311, CiteScore: 1)
Hamdan Medical J.     Open Access  
Heart and Mind     Open Access  
Heart India     Open Access   (Followers: 2)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 4)
Ibnosina J. of Medicine and Biomedical Sciences     Open Access   (Followers: 1)
IJS Short Reports     Open Access  
Imam J. of Applied Sciences     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.478, CiteScore: 1)
Indian J. of Burns     Open Access   (Followers: 3)
Indian J. of Cancer     Open Access   (Followers: 1, SJR: 0.361, CiteScore: 1)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.37, CiteScore: 1)
Indian J. of Dental Research     Open Access   (Followers: 5, SJR: 0.266, CiteScore: 1)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 2)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.468, CiteScore: 1)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 4, SJR: 0.445, CiteScore: 1)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1, SJR: 0.791, CiteScore: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4, SJR: 0.568, CiteScore: 1)
Indian J. of Health Sciences and Biomedical Research KLEU     Open Access   (Followers: 3)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.425, CiteScore: 1)
Indian J. of Medical Microbiology     Open Access   (Followers: 2, SJR: 0.503, CiteScore: 1)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.656, CiteScore: 1)
Indian J. of Medical Sciences     Open Access   (Followers: 3, SJR: 0.102, CiteScore: 0)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.347, CiteScore: 1)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.23, CiteScore: 0)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 3, SJR: 0.225, CiteScore: 1)
Indian J. of Ophthalmology     Open Access   (Followers: 5, SJR: 0.498, CiteScore: 1)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 8, SJR: 0.392, CiteScore: 1)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.199, CiteScore: 0)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 3)
Indian J. of Pain     Open Access   (Followers: 2)
Indian J. of Palliative Care     Open Access   (Followers: 9, SJR: 0.454, CiteScore: 1)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 4, SJR: 0.276, CiteScore: 1)
Indian J. of Pharmacology     Open Access   (Followers: 1, SJR: 0.412, CiteScore: 1)
Indian J. of Psychiatry     Open Access   (Followers: 2, SJR: 0.408, CiteScore: 1)
Indian J. of Psychological Medicine     Open Access   (SJR: 0.368, CiteScore: 1)
Indian J. of Public Health     Open Access   (Followers: 1)
Indian J. of Radiology and Imaging     Open Access   (Followers: 5)
Indian J. of Research in Homoeopathy     Open Access   (Followers: 2)
Indian J. of Respiratory Care     Open Access   (Followers: 3)
Indian J. of Rheumatology     Open Access   (Followers: 1, SJR: 0.119, CiteScore: 0)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.34, CiteScore: 0)
Indian J. of Social Psychiatry     Open Access   (Followers: 1)
Indian J. of Transplantation     Open Access  
Indian J. of Urology     Open Access   (Followers: 5, SJR: 0.434, CiteScore: 1)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Indian Spine J.     Open Access  
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intervention     Open Access   (Followers: 2)
Intl. Archives of Health Sciences     Open Access  
Intl. J. of Abdominal Wall and Hernia Surgery     Open Access   (Followers: 1)
Intl. J. of Academic Medicine     Open Access   (Followers: 1)
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Clinicopathological Correlation     Open Access   (Followers: 1)
Intl. J. of Community Dentistry     Open Access  
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1, SJR: 0.192, CiteScore: 0)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 8, SJR: 0.142, CiteScore: 0)
Intl. J. of Growth Factors and Stem Cells in Dentistry     Open Access  
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 6)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.535, CiteScore: 1)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4, SJR: 0.17, CiteScore: 0)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 4)
Intl. J. of Orofacial Biology     Open Access   (Followers: 1)
Intl. J. of Orofacial Research     Open Access   (Followers: 2)
Intl. J. of Orthodontic Rehabilitation     Open Access   (Followers: 2)
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 2)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.623, CiteScore: 1)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 5, SJR: 0.653, CiteScore: 1)
Intl. J. of the Cardiovascular Academy     Open Access   (SJR: 0.105, CiteScore: 0)
Intl. J. of Trichology     Open Access   (SJR: 0.4, CiteScore: 1)
Intl. J. of Yoga     Open Access   (Followers: 17)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 7)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 3)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Acute Disease     Open Access   (SJR: 0.163, CiteScore: 1)
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 3, SJR: 0.309, CiteScore: 1)

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Similar Journals
Journal Cover
International Journal of Clinical and Experimental Physiology
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2348-8832 - ISSN (Online) 2348-8093
Published by Medknow Publishers Homepage  [420 journals]
  • News and Views

    • Authors: Kuzhanthaivelu Karthiga
      Abstract: Sleep disturbances occur very often during pregnancy. These disturbances are due to physiologic, hormonal and physical changes associated with pregnancy.[1] Sleep disturbances in pregnancy may be a risk factor for hypertension, which can lead to maternal and fetal complications.[2] Javaheri, et al. found that poor quality of sleep, defined as sleep efficiency ≤ 85% or short duration of sleep (≤ 6.5 h), was associated with elevated blood pressure in adolescents.[3] Similar to non-pregnant women, sleep disturbances can lead to increased blood pressure in pregnant women. Suzuki, et al. found that among 192 pregnant women, 88% of them had sleep disturbances compared with their usual experience. The changes that reported are insomnia, parasomnias, restless leg syndrome, snoring and sleep apnea. The most frequent self-reported causes of sleep disturbance during pregnancy were urinary frequency, back or hip ache and heartburn.[4] Okun and Coussons-Read reported that pregnant women had an increased number of naps, awakenings during night time and poor sleep quality than non-pregnant women.[5] Hypertensive disorders in pregnancy could cause maternal morbidity later in life and it predisposes to cardiovascular disease in future.[6] Read more...
      PubDate: Fri, 08 Jan 2021 07:05:02 +000
       
  • Transient Receptor Potential Vanilloid 1 - A Doubtful Ambitious Modality
           for Manipulation

    • Authors: Majid Malaki
      Abstract: Sir, Transient Receptor Potential Vanilloid 1 (TRPV1) is the most widely studied member of the TRPV family. They act as a non-selective cationic ligandgated channel on neuronal and non-neuronal cell membrane and highly permeable to calcium. TRPV1 is distributed widely in the peripheral nervous system, autonomic nervous system and different parts of the brain and essential organs such as the pancreas, liver, lung, kidney and heart. TRPV1 acts as a multisensory receptor for receiving potential injury signals, they can be activated by many exogenous and endogenous mediators that involve in physiological reactions, initiate inflammation and transmit pain signal.[1] TRPV1 mediates secretion of proinflammatory factors such as tachykinin and calcitonin gene-related peptide (CGRP) in nerve endings that causes “neurogenic inflammation” which includes bronchoconstriction, tracheal mucosal edema, inflammatory cell chemo taxis and increased protein secretion. Exogenous and endogenous pro-inflammatory mediators such as capsaicin, resiniferatoxin, PGE2, citric acid and low pH lead to inflammation and chronic cough by increasing TRPV1 expression. TRPV1 can impair immune system by the action of a suppressor of interferon-gamma released by CGRP which is a critical cytokine for innate and adaptive immunity, activation of macrophages, stimulation of natural killer cells down-regulation and neutrophils to prevent virus replication and anti-inflammatory action by promoting some interleukins (IL-10). TRPV1 is a chemosensor in sympathetic neurons and promoter of airway inflammation in the non-neural system. All these evidences indicated that capsaicin, a TRPV1 agonist induces the release of IL-8, as a chemokine that triggers cytokine storm in infections while capsazepine, an antagonist of TRPV1 blocks the pro-inflammatory process.[1-4] Read more...
      PubDate: Fri, 08 Jan 2021 06:58:59 +000
       
  • Assessment of Role of Dopamine in Medial Amygdala on Body Weight,
           Metabolic Profile and Lipid Risk Factors in Albino Wistar Rats

    • Authors: Kannan Balakrishnan; Gopal Krushna Pal, Nivedita Nanda, Yerrabelli Dhanalakshmi, Balakumar Bharathi, Manoharan Renugasundari, Pravati Pal
      Abstract: Background and Aim: The present study was conducted to assess the role of dopamine in amygdala in the body weight, blood glucose, lipid profile and lipid risk factors in albino Wistar rats. Methods: A total of 16 albino Wistar rats were taken for the study and were divided into medial amygdalar group and control group with 8 rats in each group. Stereotaxic cannulation was performed and dopamine was injected into the medial amygdalar nuclei. Blood sample was obtained for estimation of metabolic parameters (blood glucose and lipid parameters) before and after dopamine injection, by computerized metabometer and autoanalyzer. Results: Following dopamine injection, there was decrease in body weight, blood glucose, lipid profile and lipid risk factors in medial amygdala group compared to control group. There was positive correlation of body weight with blood glucose, triglyceride, very low-density lipoprotein and atherogenic index. Conclusion: Decrease in body weight, blood glucose, lipid profile and lipid risk factors induced by dopamine in medial amygdalar group could be linked to reduction in cardiometabolic risks in these rats. Reduction in body weight could be the key element in inducing reduction of cardiometabolic risks.
      PubDate: Fri, 08 Jan 2021 06:50:14 +000
       
  • Assessment of Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio in
           Iron Deficiency Anemia

    • Authors: Anand Nagesh Hegde; Nagaraja Puranik
      Abstract: Background and Aim: The present study is undertaken to investigate and establish the alteration in the neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in iron deficiency anemia patients and to elucidate the link between iron with immunity and hemostasis. Methods: Complete hemogram along with differential leucocyte count and platelet count was done in 100 untreated iron deficiency anemia patients, who are visiting/admitted to KIMS, OPD, Hubballi, using Automated analyzer (HP 120). Results: The results of the present study showed clearly that there is a significant increase (P<0.05) in neutrophil-lymphocyte ratio as well as platelet-lymphocyte ratio among moderate and severe anaemic patients compared to normal individuals. Moreover, this increase in the ratio is more evident as the severity of anemia is increased. Conclusion: The alteration in neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in these patients may be due to low levels of iron as iron has a vital role in proliferation of different blood cells, especially lymphocytes. Thus, the outcome of the present study may be suggestive of a probable link between iron and immunity.
      PubDate: Fri, 08 Jan 2021 06:20:42 +000
       
  • Assessment of Lower Limb Flexibility in Female Bharatanatyam Dancers

    • Authors: Jyothi S; Sujaya B
      Abstract: Background and Aim: Bharatanatyam is one of the Indian classical dance forms. Aramandi which is similar to Demi plie position of ballet dancers and Muzumandi are the commonest poses in this dance form. Attaining these poses requires adequate range of motion at the joints and so flexibility is considered as an essential element of normal biomechanical functioning in dance. The objective of the study was to assess the range of motion at hip, knee and ankle joints using goniometer and compare the results between dancers and nondancers. Methods: Thirty-two bharatanatyam dancers and 33 non-dancers in the age group of 18-23 years participated in this study. The range of motion for different movements at hip, knee and ankle joints was assessed using goniometer. Data obtained was expressed as mean±SD and independent t test was used to compare the data. Results: Dancers had a significantly higher range of motion for flexion (P=0.002) and abduction (P<0.001) at hip joint. Range of motion for external rotation was higher in dancers than non-dancers but not statistically significant. Conclusion: This study showed that dancers had higher range of motion for some movements at hip joint but flexibility did not differ from non-dancers at knee and ankle joints. Additional physical training techniques can be employed to improve the flexibility which will reduce incidence of injuries and improve performance.
      PubDate: Fri, 08 Jan 2021 05:50:07 +000
       
  • Study on the Optimum Parameters of Alternating Magnetic Field Treatments
           against Cerebral Ischemia/Reperfusion Injury in Rats

    • Authors: Won Jong; Myong Hui Kim
      Abstract: Background and Aim: Cerebral ischemia/reperfusion injury is a major cause of acute brain injury. The pathogenetic mechanisms underlying ischemia/ reperfusion injury involve apoptosis, inflammation and oxidative stress. The aim of this study is to clarify the optimum parameters of low-frequency alternating magnetic field treatment for the functional recovery after MCAO reperfusion injury in rats by using Taguchi method. Methods: Brain samples from ischemic hemisphere were removed and weighed to measure the brain water content as brain water content is considered as index to estimate the ischemic-reperfusion injury. Results: Neuroprotective effects of low-frequency alternating magnetic fields after the middle cerebral artery occlusion reperfusion injury in rats are most likely to be exerted on parameters with intensity of 15mT, frequency of 20Hz and duration of 15 min for one time. Conclusion: Contribution ratio of frequency among parameters of alternating magnetic field is the highest for neuroprotective effects.
      PubDate: Fri, 08 Jan 2021 05:38:22 +000
       
  • Pregnancies Complicated by Diabetes, Hypertension and Hypothyroidism: Role
           of Insulin Resistance

    • Authors: Papa Dasari; Nivedita Nanda
      Abstract: During recent times we are dealing with multiple medical complications occurring in a single pregnant woman. It is well known fact that insulin resistance is present during normal pregnancy and it is relatively diabetogenic state. In women with genetic predisposition, diabetes, hypertension and hypothyroidism complicate pregnancy resulting in increased maternal and perinatal morbidity and mortality. There was evidence in the literature regarding insulin resistance and gestational diabetes. This review analysed the literature regarding the association of diabetes, hypertension and hypothyroidism and found that there is a linkage between these three disorders in pregnant state and the insulin resistance develops by multiple molecular mechanisms both centrally and in peripheral tissues. The key mechanism is insulin receptor substrate-1 (IRS-1) which gets inactivated by serine phosphorylation and leads to hyperglycaemia which in turn leads to stimulation of beta cells of pancreas and leads to hyperinsulinaemia. Pancreas has thyroid hormone receptors and this stimulates the secretion of insulin leading hyperinsulinaemia. Hyperglycaemia leading to increase in free fatty acids and together with proinflammatory factors and reactive oxygen species causes endothelial dysfunction and hypertension. More studies are necessary to target insulin receptor to increase insulin sensitivity and prevent these disorders occurring together.
      PubDate: Fri, 08 Jan 2021 05:19:11 +000
       
  • Premetabolic Syndrome is a Major Cardiovascular Disease Risk in Indian
           Population

    • Authors: Gopal Krushna Pal
      Abstract: The metabolic syndrome (MS) is characterized by several cardiovascular (CV) risk factors and is associated with an increased incidence of diabetes, CV events and mortality. The prevalence of MS is increasing in epidemic proportions worldwide, but presently it is most common in India. MS is characterized by the presence of abdominal obesity, high fasting glucose, atherogenic dyslipidemia and high blood pressure.[1] MS is related to other comorbidities including, prothrombotic state, proinflammatory state, non-alcoholic steatohepatitis and reproductive disorders. MS is also associated with increased risk of type 2 diabetes, CV disease and all-cause mortality. Furthermore, there is evidence that MS is an effective clinical tool to identify individual’s predisposition to high risk of CV disease and type 2 diabetes. Prevalence of MS is increasing in epidemic proportions in both developed countries and developing countries. The worldwide prevalence of MS in the adult population is estimated between 20% and 25%. According to data from the National Health and Nutrition Examination Survey (NHANES) 2009–2010, about one-fifth of the adult population of the United States had high cardiometabolic risk, with the prevalence of MS (adjusted for age) being estimated at 22.9%.[2] In Indian population, the prevalence of MS is more than 40% above the age of 40 years.[3]
      PubDate: Fri, 08 Jan 2021 05:07:35 +000
       
  • Assessment of Action of Statins in End Stage Renal Disease

    • Authors: Majid Malaki
      Abstract: Background and Aim: Chronic kidney disease (CKD) is one among the highest cause of morbidity globally. Statins are the top list of drugs used for them. It has been shown that the action of statins in severe CKD is paradoxical because lipid management cannot increase their survival. Methods: Sixteen CKD patients on dialysis for not less than 6 months who were receiving low dose of atorvastatin were recruited into the study. Blood investigations were performed and their results were compared with another group of non-user of lipid lowering agents. Results: Lipid profile, uric acid, calcium, phosphorous, parathyroid hormone, Vitamin D increased but these changes were significant in uric acid and Vitamin D level in the dialysis patients who receive low dose atorvastatin when compared to nonusers of atorvastatin. Conclusion: Our results showed that atorvastatin in low dose can increase serum vitamin D and serum uric acid in ESRD patients. This side effect can be the herald of accelerated cardiovascular disease and metabolic bone disease. In contrary to popular belief, statins effect on CKD patients is deleterious by increase serum uric acid in an unknown mechanism.
      PubDate: Fri, 08 Jan 2021 00:00:00 +000
       
 
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