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Publisher: Medknow Publishers   (Total: 429 journals)

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Showing 1 - 200 of 429 Journals sorted alphabetically
Acta Medica Intl.     Open Access   (SJR: 0.101, CiteScore: 0)
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advanced Biomedical Research     Open Access  
Advances in Human Biology     Open Access   (Followers: 3)
Advances in Skeletal Muscle Function Assessment     Open Access  
African J. for Infertility and Assisted Conception     Open Access  
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.25, CiteScore: 1)
African J. of Trauma     Open Access   (Followers: 1)
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Alexandria J. of Pediatrics     Open Access  
Ancient Science of Life     Open Access   (Followers: 5)
Anesthesia : Essays and Researches     Open Access   (Followers: 10)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.258, CiteScore: 1)
Annals of Bioanthropology     Open Access   (Followers: 4)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.308, CiteScore: 1)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery     Open Access  
Annals of Indian Psychiatry     Open Access  
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 8, SJR: 0.352, CiteScore: 1)
Annals of Saudi Medicine     Open Access   (SJR: 0.238, CiteScore: 1)
Annals of Thoracic Medicine     Open Access   (Followers: 5, SJR: 0.524, CiteScore: 1)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 13, SJR: 0.152, CiteScore: 0)
Annals of Tropical Pathology     Open Access  
Apollo Medicine     Open Access  
APOS Trends in Orthodontics     Open Access  
Arab J. of Interventional Radiology     Open Access  
Archives of Cardiovascular Imaging     Open Access   (Followers: 1, SJR: 0.187, CiteScore: 0)
Archives of Intl. Surgery     Open Access   (Followers: 10, SJR: 0.302, CiteScore: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Medicine and Surgery     Open Access  
Archives of Pharmacy Practice     Open Access   (Followers: 6, SJR: 0.102, CiteScore: 0)
Archives of Trauma Research     Open Access   (Followers: 3, SJR: 0.37, CiteScore: 2)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 4)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.856, CiteScore: 2)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.35, CiteScore: 1)
Asian Pacific J. of Reproduction     Open Access   (SJR: 0.227, CiteScore: 1)
Asian Pacific J. of Tropical Biomedicine     Open Access   (Followers: 2, SJR: 0.491, CiteScore: 2)
Asian Pacific J. of Tropical Medicine     Open Access   (Followers: 1, SJR: 0.561, CiteScore: 2)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
Biomedical and Biotechnology Research J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Canadian J. of Rural Medicine     Full-text available via subscription   (SJR: 0.202, CiteScore: 0)
Cancer Translational Medicine     Open Access   (Followers: 2)
Cardiology Plus     Open Access  
Chinese Medical J.     Open Access   (Followers: 10, SJR: 0.52, CiteScore: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Cancer Investigation J.     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 2)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 10, SJR: 0.811, CiteScore: 2)
Contemporary Clinical Dentistry     Open Access   (Followers: 4, SJR: 0.353, CiteScore: 1)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.543, CiteScore: 1)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.152, CiteScore: 0)
Dental Research J.     Open Access   (Followers: 11, SJR: 0.416, CiteScore: 1)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 6, SJR: 0.242, CiteScore: 0)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1, SJR: 1.799, CiteScore: 2)
Egyptian J. of Chest Diseases and Tuberculosis     Open Access   (Followers: 3, SJR: 0.155, CiteScore: 0)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.127, CiteScore: 0)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Nursing J.     Open Access  
Egyptian Orthopaedic J.     Open Access   (Followers: 2)
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.822, CiteScore: 2)
Environmental Disease     Open Access   (Followers: 2)
Eurasian J. of Pulmonology     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.749, CiteScore: 2)
European J. of General Dentistry     Open Access   (Followers: 1, SJR: 0.12, CiteScore: 0)
European J. of Prosthodontics     Open Access   (Followers: 3)
European J. of Psychology and Educational Studies     Open Access   (Followers: 11, SJR: 0.113, CiteScore: 0)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.112, CiteScore: 0)
Genome Integrity     Open Access   (Followers: 3, SJR: 0.153, CiteScore: 0)
Glioma     Open Access  
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Gynecology and Minimally Invasive Therapy     Open Access   (SJR: 0.311, CiteScore: 1)
Hamdan Medical J.     Open Access  
Heart and Mind     Open Access  
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
Ibnosina J. of Medicine and Biomedical Sciences     Open Access  
IJS Short Reports     Open Access  
Imam J. of Applied Sciences     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.478, CiteScore: 1)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (Followers: 1, SJR: 0.361, CiteScore: 1)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.37, CiteScore: 1)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.604, CiteScore: 1)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.266, CiteScore: 1)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.468, CiteScore: 1)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 5, SJR: 0.445, CiteScore: 1)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1, SJR: 0.791, CiteScore: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4, SJR: 0.568, CiteScore: 1)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.425, CiteScore: 1)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.503, CiteScore: 1)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.656, CiteScore: 1)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.102, CiteScore: 0)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.347, CiteScore: 1)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.23, CiteScore: 0)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 3, SJR: 0.225, CiteScore: 1)
Indian J. of Ophthalmology     Open Access   (Followers: 4, SJR: 0.498, CiteScore: 1)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 8, SJR: 0.392, CiteScore: 1)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.199, CiteScore: 0)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.454, CiteScore: 1)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 2, SJR: 0.276, CiteScore: 1)
Indian J. of Pharmacology     Open Access   (SJR: 0.412, CiteScore: 1)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.311, CiteScore: 0)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.408, CiteScore: 1)
Indian J. of Psychological Medicine     Open Access   (SJR: 0.368, CiteScore: 1)
Indian J. of Public Health     Open Access   (Followers: 1)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Respiratory Care     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.119, CiteScore: 0)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.34, CiteScore: 0)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Transplantation     Open Access  
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Indian Spine J.     Open Access  
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intervention     Open Access   (Followers: 1)
Intl. Archives of Health Sciences     Open Access  
Intl. J. of Abdominal Wall and Hernia Surgery     Open Access  
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Clinicopathological Correlation     Open Access  
Intl. J. of Community Dentistry     Open Access  
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1, SJR: 0.192, CiteScore: 0)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 3, SJR: 0.142, CiteScore: 0)
Intl. J. of Growth Factors and Stem Cells in Dentistry     Open Access  
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 6)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.535, CiteScore: 1)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4, SJR: 0.17, CiteScore: 0)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 2)
Intl. J. of Orofacial Biology     Open Access  
Intl. J. of Orofacial Research     Open Access  
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.623, CiteScore: 1)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 5, SJR: 0.653, CiteScore: 1)
Intl. J. of the Cardiovascular Academy     Open Access   (SJR: 0.105, CiteScore: 0)
Intl. J. of Trichology     Open Access   (SJR: 0.4, CiteScore: 1)
Intl. J. of Yoga     Open Access   (Followers: 13)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 5)

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Journal Cover
Clinical Cancer Investigation Journal
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2278-1668 - ISSN (Online) 2278-0513
Published by Medknow Publishers Homepage  [429 journals]
  • Adipokine Role in Normal and Neoplastic Bone Marrow Niche

    • Authors: Behrouz Yazdanpanah, Mohammad Shahjahani, Faezeh Seif, Elahe Khodadi, Saeid Shahrabi
      Pages: 37 - 42
      Abstract: Behrouz Yazdanpanah, Mohammad Shahjahani, Faezeh Seif, Elahe Khodadi, Saeid Shahrabi
      Clinical Cancer Investigation Journal 2018 7(2):37-42
      Bone marrow (BM) niche is an appropriate site for the growth of mesenchymal stem cells and their differentiation into adipocytes. Adipocytes are metabolically active cells affecting the function of their neighboring cells through the secretion of adipokines, growth factors, and inflammatory mediators. Although the pathological roles of adipokines have not been elucidated, the changes in their levels have been observed in various malignancies. Adipokines also affect tumor growth in the BM niche. Decreased levels of adipokines and increased levels of leptin have been reported in a number of cancers. Adipocytes can be introduced as a diagnostic marker of metastasis in some cancers. Identification of the relationship between different adipokines secreted from adipocytes and the signaling pathways activated by these adipokines, as well as the detection of molecules involved in the development of various types of malignancies, can contribute to the recognition of drug resistance factors and appropriate treatment of malignancies. In this review paper, we examine the effects of various BM-derived adipokines on the growth and metastasis of tumor cells in the neoplastic BM niche.
      Citation: Clinical Cancer Investigation Journal 2018 7(2):37-42
      PubDate: Thu,8 Mar 2018
      DOI: 10.4103/ccij.ccij_90_17
      Issue No: Vol. 7, No. 2 (2018)
       
  • Genetics and Epigenetics of Glioblastoma: Therapeutic Challenges

    • Authors: Saleh Rasras, Kazem Zibara, Tina Vosughi, Zeinab Deris Zayeri
      Pages: 43 - 49
      Abstract: Saleh Rasras, Kazem Zibara, Tina Vosughi, Zeinab Deris Zayeri
      Clinical Cancer Investigation Journal 2018 7(2):43-49
      Glioblastoma is a brain tumor that develops due to both genetic and epigenetic risk factors. Crosstalk between the genetic and the epigenetic offers new possibilities for therapy. Abnormal methylation of methylguanine-DNA methyltransferase (MGMT) promoter region and isocitrate dehydrogenase 1 (IDH1) mutations are prognostic and therapeutic response markers in glioblastoma. Mutations in genes such as epidermal growth factor receptor, TP53, and P16 have been reported in glioblastoma; therefore, they might associate with survival and worth to be used in estimating survival risks. MKI67 expression associates with posttreatment such as adjuvant radiotherapy results evaluation. On the other hand, monosomies, such as deletions of chromosome 10, especially q23 and q25–26, are good markers for estimating the progression and aggressiveness of glioblastoma. The profile of MGMT methylation is modified in glioblastoma and hence can be a good target for epigenetic drugs. Other useful strategies in the treatment of gliomas include several micro-RNAs (MiRs) which are alerted in glioblastoma and which affect the regulation of mRNAs are associated with gene expression profiles of the disease. Epigenetic drugs, such as azacitidine and decitabine, which belong to the DNA methyltransferases (DNMT) inhibitor 5-aza-2'deoxycytidine (5-aza-dC), can suppress DNMT1 and stimulate tumor suppressor genes expression. MGMT methylation status and IDH mutational status are two valuable prognosis and therapeutic response markers in glioblastoma. Regulation of glioblastoma through epigenetic drugs, such as not only inhibitors of EZH2, histone deacetylase, and DNMT, but also MiRs, are promising approaches in glioblastoma treatment. Improves in understanding cancer genetic and epigenetic disruptions is the key point in solving the puzzle of glioblastoma treatment.
      Citation: Clinical Cancer Investigation Journal 2018 7(2):43-49
      PubDate: Thu,8 Mar 2018
      DOI: 10.4103/ccij.ccij_82_17
      Issue No: Vol. 7, No. 2 (2018)
       
  • Evaluation of DNA Damage in Peripheral Blood Leukocytes in Oral
           Potentially Malignant and Malignant Disorders by Comet Assay

    • Authors: Garima Rawat, Aadithya B Urs, Anita Chakravarti, Priya Kumar
      Pages: 50 - 55
      Abstract: Garima Rawat, Aadithya B Urs, Anita Chakravarti, Priya Kumar
      Clinical Cancer Investigation Journal 2018 7(2):50-55
      Purpose: Oral squamous cell carcinoma (OSCC) and potentially malignant disorders (PMD) are associated with DNA damage which can be caused by exposure to carcinogens, genotoxins, or increased oxidative stress. Early detection and assessment of the amount of DNA damage using a biomarker such as a comet assay can prove to be extremely beneficial for the patients. The present study evaluated the efficacy of comet assay in assessing DNA damage in peripheral blood leukocytes (PBLs) in oral potentially malignant and malignant disorders. Materials and Methods: The study included fifty-five patients each of leukoplakia, oral submucous fibrosis (OSMF), and OSCC along with fifty-five healthy individuals as control. The patients with deleterious oral habits were categorized into smokeless, smoked, and mixed habit groups. DNA damage was evaluated by measuring the mean tail length (μm). Results: An increased mean tail length (μm) and higher DNA damage were found in OSCC (22.4335 ± 1.52341), and there was a progressive stepwise increase in mean tail length from control (6.8307 ± 0.84261) to PMD (leukoplakia [13.0022 ± 0.74316]; OSMF [10.6085 ± 0.88140]) to OSCC. Although there was a significant increase in the DNA damage in different habit groups (smokeless [14.9380 ± 5.18516]; smoked [15.4947 ± 4.59589], and mixed [16.3650 ± 5.62407]) compared to controls, there was no significant difference between the habit groups. Conclusion: Thus, comet assay technique can be used as a sensitive and reliable indicator for DNA damage evaluation.
      Citation: Clinical Cancer Investigation Journal 2018 7(2):50-55
      PubDate: Thu,8 Mar 2018
      DOI: 10.4103/ccij.ccij_66_17
      Issue No: Vol. 7, No. 2 (2018)
       
  • Orofacial Rhabdomyosarcoma: A 5-year Clinicopathologic Study from
           Sub-Saharan Africa

    • Authors: Adebayo Aremu Ibikunle, Abdurrazaq Olanrewaju Taiwo, Ramat Oyebunmi Braimah, Kabir Abdullahi, Usman A Malami
      Pages: 56 - 61
      Abstract: Adebayo Aremu Ibikunle, Abdurrazaq Olanrewaju Taiwo, Ramat Oyebunmi Braimah, Kabir Abdullahi, Usman A Malami
      Clinical Cancer Investigation Journal 2018 7(2):56-61
      Background: Rhabdomyosarcoma (RMS) is an aggressive malignant neoplasm of mesenchymal origin. Its common sites of occurrence are the extremities and the genitourinary system, being less frequently seen in the orofacial region. There is paucity of literature, especially from sub-Saharan Africa on orofacial RMS. Materials and Methods: Records of all patients managed for orofacial RMS between January 2013 and November 2017 at the Department of Dental and Maxillofacial surgery of Usmanu Danfodiyo University Teaching Hospital were obtained. Data retrieved include sociodemographics, clinical features (including the tumor, node, and metastasis [TNM] stage and Intergroup RMS Study risk classification), histological type, and mode of treatment. Data were recorded and analyzed using IBM SPSS Statistics for Windows version 20 (Armonk, IBM Corp., NY, USA). Results: Twenty-one patients were included. There were 17 (81.0%) males and 4 (19.1%) females, giving a male-to-female ratio of 4.3:1. Age ranged from 2 to 76 years (mean [±standard deviation] of 15.8 [±16.8]). Majority of them belonged to the low socioeconomic group. The duration of the symptoms ranged from 2 to 9 months. The midface was the most commonly involved sites. Majority of the cases were nonparameningeal 14 (66.7%). Regional nodal metastasis was clinically present in 9 (42.9%) cases. Embryonal RMS was the most frequently encountered histological type (11 [52.4%]). Treatment was multimodal in 11 (52.4%) cases and 3 (14.1%) had recurrence. Conclusion: Orofacial RMS may occur in any age group although it may be more commonly seen in the first decade of life. Unimodal treatment may be successfully deployed in carefully selected cases. Prognosis remains poor in our climes.
      Citation: Clinical Cancer Investigation Journal 2018 7(2):56-61
      PubDate: Thu,8 Mar 2018
      DOI: 10.4103/ccij.ccij_1_18
      Issue No: Vol. 7, No. 2 (2018)
       
  • KAI-1 ad p53 Expression in Odontogenic Cysts: An Immunohistochemical
           Marker Study

    • Authors: Namrata N Patil, Vijay Wadhwan, Abhishek Singh Nayyar, Minal Chaudhary, Santhosh D Reddy, KV Chalapathi
      Pages: 62 - 69
      Abstract: Namrata N Patil, Vijay Wadhwan, Abhishek Singh Nayyar, Minal Chaudhary, Santhosh D Reddy, KV Chalapathi
      Clinical Cancer Investigation Journal 2018 7(2):62-69
      Background: KAI-1/CD82 is a tumor suppressor gene with decreased gene expression being associated with increased invasive ability of oral squamous cell carcinoma and as hypothesized for various odontogenic cysts and tumors. p53 protein functions in G1-S phase of the cell cycle to allow the repair of damaged DNA. In the present study, p53 and KAI-1 expression was investigated using monoclonal antibodies in the various odontogenic cysts. Aims: To detect KAI-1 and p53 expression in radicular cysts, dentigerous cysts, and odontogenic keratocysts (OKCs) and to assess the relation between p53 and KAI-1 expression in the aforementioned cysts. Materials and Methods: The present study included histopathologically diagnosed cases of radicular cysts, dentigerous cysts, and OKCs for the expression of KAI-1 and p53 antibodies. Results: Among odontogenic cysts, radicular cysts expressed maximum positivity of KAI-1 (20.92%) while p53-positive cells were maximum in OKC (4.04%). The correlation between KAI-1 and p53 expression in the various odontogenic cysts was not found to be significant. Conclusion: The increased KAI-1 expression in the radicular cysts and its downregulation in OKCs may be indicative of aggressive clinical behavior and the fact that OKCs are hypothesized as neoplastic rather than being developmental in origin.
      Citation: Clinical Cancer Investigation Journal 2018 7(2):62-69
      PubDate: Thu,8 Mar 2018
      DOI: 10.4103/ccij.ccij_3_17
      Issue No: Vol. 7, No. 2 (2018)
       
  • Frozen Section versus Paraffin Section in Diagnosis of Breast Lesions: A
           Comparative Study

    • Authors: Vaanika Kaira, Anil Kumar Gupta, Asha Agarwal, Sanjay Kala, Pankaj Kaira
      Pages: 70 - 73
      Abstract: Vaanika Kaira, Anil Kumar Gupta, Asha Agarwal, Sanjay Kala, Pankaj Kaira
      Clinical Cancer Investigation Journal 2018 7(2):70-73
      Background: Frozen section (FS) examination has a number of indications such as identification of tissue type, benign versus malignant nature of the tissue, type of malignancy, determination of surgical margins, positivity of lymph nodes, and presence of malignant implants and/or metastasis in other tissues. Contraindications to the use of FS exist such as small lesions that could be destroyed by the freezing and sectioning and leaving no tissue for a definitive diagnosis. Therefore, this prospective study was planned to compare the accuracy of FSs versus paraffin sections in diagnosis of breast lesions. Subjects and Methods: The present prospective study was conducted from December 2008 to September 2010 in the Department of Pathology, GSVM. Medical College, Kanpur. A total of 115 cases were studied including benign and malignant breast lesions. Results were compared between FS diagnosis, and gold standard paraffin section diagnosis was evaluated, following Hematoxylin and Eosin staining and analyzed for accuracy in terms of false positivity and false negativity. Results: Out of 115 cases in our study, concordance was found in 109 cases. In our study, concordance for malignant breast lesion was 100%, whereas for benign lesions, it was 95.9%. Four cases (3.5%) were deferred to paraffin section diagnosis and two cases (1.8%) were misdiagnosed on FS. Conclusions: Diagnosis by FS is accurate to 100% in case of malignancy and confirming up to 96% for benign lesions. Its use, thus during breast surgery, is advocated for better clinical management of patients.
      Citation: Clinical Cancer Investigation Journal 2018 7(2):70-73
      PubDate: Thu,8 Mar 2018
      DOI: 10.4103/ccij.ccij_69_17
      Issue No: Vol. 7, No. 2 (2018)
       
  • Renal Cell Carcinoma in Pregnancy: Radical Nephrectomy and the Use of
           Dexmedetomidine

    • Authors: Uma Hariharan, Neha Kator, Vijay Nagpal, Lalita Chaudhary
      Pages: 74 - 76
      Abstract: Uma Hariharan, Neha Kator, Vijay Nagpal, Lalita Chaudhary
      Clinical Cancer Investigation Journal 2018 7(2):74-76
      Renal cell carcinoma is sinister cancer, uncommon during pregnancy. A 26-week period of gestation, primigravida pregnant women presented with painless hematuria and left flank fullness. She was found to have left-sided renal cell carcinoma, with no metastasis or vascular invasion. All her preoperative investigations were within normal limits, except for mild anemia. An obstetric evaluation was unremarkable, with normal fetal heart sounds. Perioperative care of pregnant patients for oncosurgery poses great challenges, affecting both the mother and the fetus. Preoperative tocolytic therapy was started to prevent preterm labor, and an obstetrician was kept standby during surgery. A combined general anesthesia with rapid sequence induction and cricoid pressure along with preinduction epidural catheter was administered, followed by the insertion of invasive monitoring lines. Dexmedetomidine use is also highlighted, as it has several beneficial effects and has been safely used in pregnant patients. The tumor was successfully removed, and the patient was transferred to the high-dependency-care unit after extubation. We hereby describe the perioperative anesthetic challenges in this unique case report.
      Citation: Clinical Cancer Investigation Journal 2018 7(2):74-76
      PubDate: Thu,8 Mar 2018
      DOI: 10.4103/ccij.ccij_75_17
      Issue No: Vol. 7, No. 2 (2018)
       
  • Alveolar Rhabdomyosarcoma of the Prostate in a Young Adult Presenting with
           Acute Retention of Urine

    • Authors: RB Nerli, Adarsh C Sanikop, Vishal Kadeli, Shridhar C Ghagane, Neeraj S Dixit, Murigendra B Hiremath
      Pages: 77 - 80
      Abstract: RB Nerli, Adarsh C Sanikop, Vishal Kadeli, Shridhar C Ghagane, Neeraj S Dixit, Murigendra B Hiremath
      Clinical Cancer Investigation Journal 2018 7(2):77-80
      Prostate rhabdomyosarcoma is rare in adults. It is characterized by a high degree of aggressiveness, rapid local growth with the formation of large pelvic masses, often leading to urethral obstruction, and systemic spread, commonly to the lungs, liver, and bone. A 23-year-old male was referred to our department with symptoms of acute retention of urine, hematuria and constipation. He was earlier admitted in another hospital, wherein he was catheterized, evaluated and underwent both transurethral as well as transrectal biopsy of the prostate. Our case was clinically advanced, and chemotherapy treatment seemed adequate to control the disease, and reduce the symptoms and improve the quality of life.
      Citation: Clinical Cancer Investigation Journal 2018 7(2):77-80
      PubDate: Thu,8 Mar 2018
      DOI: 10.4103/ccij.ccij_83_17
      Issue No: Vol. 7, No. 2 (2018)
       
  • Pure Transitional Cell Carcinoma of the Ovary: A Recently Recognized Rare
           Subtype of Ovarian Epithelial Cancer

    • Authors: Banyameen Mohamad Iqbal, Bedarshi Banerjee, Tushar Kambale, Iqra Mushtaq
      Pages: 81 - 83
      Abstract: Banyameen Mohamad Iqbal, Bedarshi Banerjee, Tushar Kambale, Iqra Mushtaq
      Clinical Cancer Investigation Journal 2018 7(2):81-83
      Transitional cell carcinoma (TCC) of the ovary is a nomenclature given by Austin and Norris to a group of malignant Brenner tumors having a benign component. It is to be noted that transitional cells tumors of the ovary are not equivalent to Brenner tumor. Microscopically, Brenner tumors consist of solid and cystic nests of epithelial cells resembling transitional epithelium (urothelium), and not transitional cell epithelium in actual, surrounded by an abundant stromal component of dense, fibroblastic nature. Most authors currently favor for Brenner tumor, an origin from surface ovarian epithelium or the cysts derived from them, through a process of metaplasia. This subtype of ovarian tumor has a favorable response to chemotherapy than other ovarian surface epithelial cancers; therefore, it warrants early recognition. We hereby present a rare case report of isolated TCC of ovary.
      Citation: Clinical Cancer Investigation Journal 2018 7(2):81-83
      PubDate: Thu,8 Mar 2018
      DOI: 10.4103/ccij.ccij_78_17
      Issue No: Vol. 7, No. 2 (2018)
       
  • Bronchoscopic Characterization of Lesions and Use of Technique Accordingly
           During Bronchoscopy

    • Authors: Sora Yasri, Viroj Wiwanitkit
      Pages: 84 - 84
      Abstract: Sora Yasri, Viroj Wiwanitkit
      Clinical Cancer Investigation Journal 2018 7(2):84-84

      Citation: Clinical Cancer Investigation Journal 2018 7(2):84-84
      PubDate: Thu,8 Mar 2018
      DOI: 10.4103/ccij.ccij_2_18
      Issue No: Vol. 7, No. 2 (2018)
       
  • Esophageal Squamous Cell Carcinoma, Human Papillomavirus and p16

    • Authors: Mala R Gowda
      Pages: 85 - 85
      Abstract: Mala R Gowda
      Clinical Cancer Investigation Journal 2018 7(2):85-85

      Citation: Clinical Cancer Investigation Journal 2018 7(2):85-85
      PubDate: Thu,8 Mar 2018
      DOI: 10.4103/ccij.ccij_7_18
      Issue No: Vol. 7, No. 2 (2018)
       
 
 
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