Publisher: Medknow Publishers   (Total: 427 journals)

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Showing 1 - 200 of 427 Journals sorted alphabetically
Acta Medica Intl.     Open Access   (SJR: 0.101, CiteScore: 0)
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advanced Biomedical Research     Open Access  
Advances in Human Biology     Open Access   (Followers: 5)
Advances in Skeletal Muscle Function Assessment     Open Access  
African J. for Infertility and Assisted Conception     Open Access   (Followers: 1)
African J. of Medical and Health Sciences     Open Access   (Followers: 3)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.25, CiteScore: 1)
African J. of Trauma     Open Access   (Followers: 1)
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 2)
Al-Azhar Assiut Medical J.     Open Access   (Followers: 2)
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Alexandria J. of Pediatrics     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 5)
Anesthesia : Essays and Researches     Open Access   (Followers: 10)
Annals of African Medicine     Open Access   (Followers: 2, SJR: 0.258, CiteScore: 1)
Annals of Bioanthropology     Open Access   (Followers: 5)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 15, SJR: 0.308, CiteScore: 1)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery     Open Access  
Annals of Indian Psychiatry     Open Access  
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 12, SJR: 0.352, CiteScore: 1)
Annals of Saudi Medicine     Open Access   (SJR: 0.238, CiteScore: 1)
Annals of Thoracic Medicine     Open Access   (Followers: 6, SJR: 0.524, CiteScore: 1)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 14, SJR: 0.152, CiteScore: 0)
Annals of Tropical Pathology     Open Access  
Apollo Medicine     Open Access  
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access   (Followers: 1)
Archives of Cardiovascular Imaging     Open Access   (Followers: 2, SJR: 0.187, CiteScore: 0)
Archives of Intl. Surgery     Open Access   (Followers: 10, SJR: 0.302, CiteScore: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 5)
Archives of Medicine and Surgery     Open Access   (Followers: 1)
Archives of Pharmacy Practice     Open Access   (Followers: 12, SJR: 0.102, CiteScore: 0)
Archives of Trauma Research     Open Access   (Followers: 4, SJR: 0.37, CiteScore: 2)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access   (Followers: 1)
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 5)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.856, CiteScore: 2)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 2)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.35, CiteScore: 1)
Asian Pacific J. of Reproduction     Open Access   (SJR: 0.227, CiteScore: 1)
Asian Pacific J. of Tropical Biomedicine     Open Access   (Followers: 2, SJR: 0.491, CiteScore: 2)
Asian Pacific J. of Tropical Medicine     Open Access   (Followers: 1, SJR: 0.561, CiteScore: 2)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
Biomedical and Biotechnology Research J.     Open Access   (Followers: 1)
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access   (Followers: 1)
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 2)
Canadian J. of Rural Medicine     Full-text available via subscription   (Followers: 1, SJR: 0.202, CiteScore: 0)
Cancer Translational Medicine     Open Access   (Followers: 2)
Cardiology Plus     Open Access   (Followers: 1)
Chinese Medical J.     Open Access   (Followers: 10, SJR: 0.52, CiteScore: 1)
CHRISMED J. of Health and Research     Open Access   (Followers: 2)
Clinical Cancer Investigation J.     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 5)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access   (Followers: 2)
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 10, SJR: 0.811, CiteScore: 2)
Contemporary Clinical Dentistry     Open Access   (Followers: 5, SJR: 0.353, CiteScore: 1)
Current Medical Issues     Open Access   (Followers: 2)
CytoJ.     Open Access   (Followers: 3, SJR: 0.543, CiteScore: 1)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 5, SJR: 0.152, CiteScore: 0)
Dental Research J.     Open Access   (Followers: 14, SJR: 0.416, CiteScore: 1)
Dentistry and Medical Research     Open Access   (Followers: 1)
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 8, SJR: 0.242, CiteScore: 0)
Education in the Health Professions     Open Access   (Followers: 2)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1, SJR: 1.799, CiteScore: 2)
Egyptian J. of Chest Diseases and Tuberculosis     Open Access   (Followers: 3, SJR: 0.155, CiteScore: 0)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 1)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Nursing J.     Open Access  
Egyptian Orthopaedic J.     Open Access   (Followers: 2)
Egyptian Pharmaceutical J.     Open Access   (Followers: 3)
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access   (Followers: 2)
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.822, CiteScore: 2)
Environmental Disease     Open Access   (Followers: 4)
Eurasian J. of Pulmonology     Open Access  
European J. of Dentistry     Open Access   (Followers: 4, SJR: 0.749, CiteScore: 2)
European J. of General Dentistry     Open Access   (Followers: 2, SJR: 0.12, CiteScore: 0)
European J. of Prosthodontics     Open Access   (Followers: 4)
European J. of Psychology and Educational Studies     Open Access   (Followers: 11, SJR: 0.113, CiteScore: 0)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.112, CiteScore: 0)
Genome Integrity     Open Access   (Followers: 2, SJR: 0.153, CiteScore: 0)
Glioma     Open Access  
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Gynecology and Minimally Invasive Therapy     Open Access   (SJR: 0.311, CiteScore: 1)
Hamdan Medical J.     Open Access  
Heart and Mind     Open Access  
Heart India     Open Access   (Followers: 2)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
Ibnosina J. of Medicine and Biomedical Sciences     Open Access   (Followers: 1)
IJS Short Reports     Open Access  
Imam J. of Applied Sciences     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.478, CiteScore: 1)
Indian J. of Burns     Open Access   (Followers: 3)
Indian J. of Cancer     Open Access   (Followers: 1, SJR: 0.361, CiteScore: 1)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.37, CiteScore: 1)
Indian J. of Dental Research     Open Access   (Followers: 5, SJR: 0.266, CiteScore: 1)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.468, CiteScore: 1)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 4, SJR: 0.445, CiteScore: 1)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1, SJR: 0.791, CiteScore: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4, SJR: 0.568, CiteScore: 1)
Indian J. of Health Sciences and Biomedical Research KLEU     Open Access   (Followers: 3)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.425, CiteScore: 1)
Indian J. of Medical Microbiology     Open Access   (Followers: 2, SJR: 0.503, CiteScore: 1)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.656, CiteScore: 1)
Indian J. of Medical Sciences     Open Access   (Followers: 3, SJR: 0.102, CiteScore: 0)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.347, CiteScore: 1)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.23, CiteScore: 0)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 3, SJR: 0.225, CiteScore: 1)
Indian J. of Ophthalmology     Open Access   (Followers: 5, SJR: 0.498, CiteScore: 1)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 8, SJR: 0.392, CiteScore: 1)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.199, CiteScore: 0)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 2)
Indian J. of Palliative Care     Open Access   (Followers: 8, SJR: 0.454, CiteScore: 1)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 4, SJR: 0.276, CiteScore: 1)
Indian J. of Pharmacology     Open Access   (SJR: 0.412, CiteScore: 1)
Indian J. of Psychiatry     Open Access   (Followers: 2, SJR: 0.408, CiteScore: 1)
Indian J. of Psychological Medicine     Open Access   (SJR: 0.368, CiteScore: 1)
Indian J. of Public Health     Open Access   (Followers: 1)
Indian J. of Radiology and Imaging     Open Access   (Followers: 5)
Indian J. of Research in Homoeopathy     Open Access   (Followers: 2)
Indian J. of Respiratory Care     Open Access   (Followers: 3)
Indian J. of Rheumatology     Open Access   (Followers: 1, SJR: 0.119, CiteScore: 0)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.34, CiteScore: 0)
Indian J. of Social Psychiatry     Open Access   (Followers: 1)
Indian J. of Transplantation     Open Access  
Indian J. of Urology     Open Access   (Followers: 5, SJR: 0.434, CiteScore: 1)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Indian Spine J.     Open Access  
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intervention     Open Access   (Followers: 2)
Intl. Archives of Health Sciences     Open Access  
Intl. J. of Abdominal Wall and Hernia Surgery     Open Access   (Followers: 1)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Clinicopathological Correlation     Open Access   (Followers: 1)
Intl. J. of Community Dentistry     Open Access  
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1, SJR: 0.192, CiteScore: 0)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 8, SJR: 0.142, CiteScore: 0)
Intl. J. of Growth Factors and Stem Cells in Dentistry     Open Access  
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 6)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.535, CiteScore: 1)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4, SJR: 0.17, CiteScore: 0)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 3)
Intl. J. of Orofacial Biology     Open Access   (Followers: 1)
Intl. J. of Orofacial Research     Open Access   (Followers: 2)
Intl. J. of Orthodontic Rehabilitation     Open Access   (Followers: 2)
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 2)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.623, CiteScore: 1)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 5, SJR: 0.653, CiteScore: 1)
Intl. J. of the Cardiovascular Academy     Open Access   (SJR: 0.105, CiteScore: 0)
Intl. J. of Trichology     Open Access   (SJR: 0.4, CiteScore: 1)
Intl. J. of Yoga     Open Access   (Followers: 16)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 7)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 3)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  

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Similar Journals
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Chinese Medical Journal
Journal Prestige (SJR): 0.52
Citation Impact (citeScore): 1
Number of Followers: 10  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0366-6999 - ISSN (Online) 2542-5641
Published by Medknow Publishers Homepage  [427 journals]
  • Feasibility of coronavirus disease 2019 eradication

    • Authors: Zheng; Ya-Li; He, Yu-Kun; Ma, Xin-Qian; Gao, Zhan-Cheng
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Lung transplantation as therapeutic option in acute respiratory distress
           syndrome for coronavirus disease 2019-related pulmonary fibrosis

    • Authors: Chen; Jing-Yu; Qiao, Kun; Liu, Feng; Wu, Bo; Xu, Xin; Jiao, Guo-Qing; Lu, Rong-Guo; Li, Hui-Xing; Zhao, Jin; Huang, Jian; Yang, Yi; Lu, Xiao-Jie; Li, Jia-Shu; Jiang, Shu-Yun; Wang, Da-Peng; Hu, Chun-Xiao; Wang, Gui-Long; Huang, Dong-Xiao; Jiao, Guo-Hui; Wei, Dong; Ye, Shu-Gao; Huang, Jian-An; Zhou, Li; Zhang, Xiao-Qin; He, Jian-Xing
      Abstract: imageBackground Critical patients with the coronavirus disease 2019 (COVID-19), even those whose nucleic acid test results had turned negative and those receiving maximal medical support, have been noted to progress to irreversible fatal respiratory failure. Lung transplantation (LT) as the sole therapy for end-stage pulmonary fibrosis related to acute respiratory distress syndrome has been considered as the ultimate rescue therapy for these patients.Methods From February 10 to March 10, 2020, three male patients were urgently assessed and listed for transplantation. After conducting a full ethical review and after obtaining assent from the family of the patients, we performed three LT procedures for COVID-19 patients with illness durations of more than one month and extremely high sequential organ failure assessment scores.Results Two of the three recipients survived post-LT and started participating in a rehabilitation program. Pearls of the LT team collaboration and perioperative logistics were summarized and continually improved. The pathological results of the explanted lungs were concordant with the critical clinical manifestation, and provided insight towards better understanding of the disease. Government health affair systems, virology detection tools, and modern communication technology all play key roles towards the survival of the patients and their rehabilitation.Conclusions LT can be performed in end-stage patients with respiratory failure due to COVID-19-related pulmonary fibrosis. If confirmed positive-turned-negative virology status without organ dysfunction that could contraindicate LT, LT provided the final option for these patients to avoid certain death, with proper protection of transplant surgeons and medical staffs. By ensuring instant seamless care for both patients and medical teams, the goal of reducing the mortality rate and salvaging the lives of patients with COVID-19 can be attained.
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Effect of sustained intensive therapy with disease modifying
           anti-rheumatic drugs in rheumatoid arthritis: a 5-year real-world
           consecutive study

    • Authors: Cai; Yue-Ming; Li, Ru; Ye, Hua; He, Jing; Sun, Xiao-Lin; Jin, Jia-Yang; Liu, Jia-Jia; Gan, Yu-Zhou; You, Xu-Jie; Xu, Jing; Shi, Lian-Jie; Cheng, Gong; Wang, Qing-Wen; Li, Zhan-Guo
      Abstract: imageBackground Intensive therapy with disease modifying anti-rheumatic drugs (DMARDs) has been reported to improve the outcomes of rheumatoid arthritis (RA). However, real-world study on the effect of intensive therapy on RA sustained remission is still lacking. This study aimed to investigate the outcome of sustained intensive DMARD therapy (SUIT) for RA in a real-world 5-year consecutive cohort.Methods Based on a consecutive cohort of 610 out-patients with RA, remission of RA was assessed in 541 patients from 2012 to 2017, by dividing into SUIT, non-SUIT, and intermittent SUIT (Int-SUIT) groups. Changes in the disease activity scores were evaluated by 28-joint disease activity score based on erythrocyte sedimentation rate (DAS28-ESR), 28-joint disease activity score based on C-reactive protein (DAS28-CRP), and clinical deep remission criteria (CliDR). Cumulative remission rates between different groups were compared using Kaplan-Meier curves and predictive factors of sustained remission were identified by univariate and multivariate logistic regression analysis.Results The remission rates of the SUIT group decreased from 12.0% (65/541) to 5.6% (20/359) based on DAS28-ESR, from 14.0% (76/541) to 7.2% (26/359) based on DAS28-CRP, and from 8.5% (46/541) to 3.1% (11/359) based on CliDR, respectively, with a gradually decreasing trend during the 5 years. The SUIT regimen led to a significantly higher cumulative remission rate than non-SUIT regimen based on DAS28-ESR (39.7% vs. 19.5%, P = 0.001), DAS28-CRP (42.0% vs. 19.6%, P = 0.001), and CliDR (24.5% vs. 8.7%, P = 0.001). The cumulative remission rates of patients treated with SUIT regimen were significantly higher than those treated with Int-SUIT regimen based on DAS28-ESR (39.7% vs. 25.7%, P = 0.043) and CliDR (24.5% vs. 14.2%, P = 0.047), but there was no significant difference between the two groups based on DAS28-CRP (42.0% vs. 27.4%, P = 0.066). Multivariate logistic regression analysis showed that the use of SUIT regimen was an independent favorable predictor according to different remission definitions (for DAS28-ESR: odds ratio [OR], 2.215, 95% confidence interval [CI]: 1.271–3.861, P = 0.005; for DAS28-CRP: OR, 1.520, 95% CI: 1.345–1.783, P = 0.002; for CliDR: OR, 1.525, 95% CI: 1.314–1.875, P = 0.013).Conclusion Sustained intensive treatment of RA is an optimal strategy in daily practice and will lead to an increased remission rate.
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Clinical application of Chinese Nanjing persistent vegetative state scale

    • Authors: Wang; Pei-Dong; Gao, Li; Di, Hai-Bo; Li, Jing-Qi; Ni, Ying-Ying; Wang, De-Sheng; Ding, Xin-Sheng
      Abstract: imageBackground It is a challenge to characterize the consciousness level of patients with severe disturbance of consciousness and predict their prognosis effectively for Chinese doctors. We aimed to investigate the psychometric property and the diagnostic practicality of severe disturbance of consciousness by Chinese Nanjing persistent vegetative state scale (CNPVSS) which was first set up in 1996 and modified in 2001 and 2011.Methods The concurrent validity, inter-rater consistency and diagnostic accuracy of CNPVSS and Chinese version of coma recovery scale-revised (CRS-R) were investigated by assessment of 380 patients with severe disorders of consciousness.Results Total scores of the CNPVSS were correlated significantly with that of the CRS-R, indicating acceptable concurrent validity. Sub-scale analysis showed moderate to high inter-rater reliability and test-retest reliability. CNPVSS was superior to CRS-R on the diagnosis sensitivity. The CNPVSS was able to distinguish 65 patients in emergence from minimal consciousness state who were misclassified as in minimal consciousness state (MCS) by the CRS-R, and it could also distinguish two patients in MCS who were misclassified as in vegetative state by the CRS-R.Conclusion The CNPVSS is an appropriate measurement and is sensitive to distinguish the MCS patients from the VS patients.
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Association of serum uric acid with thyroid function in health check-up
           participants

    • Authors: Wang; Xiao-Jun; Qian, Xi-Wen; Zhang, Xu; Han, Li; Zheng, Yu-Qi; Wu, Tao; Qin, Guo-You; Ye, Zhi-Bin; Xiao, Jing
      Abstract: imageBackground The relationship of uric acid (UA) with the thyroid function among healthy individuals remains unclear. We aimed to examine the relationship between UA contents and thyroid hormone levels in healthy Chinese individuals.Methods This was a cross-sectional study of 1186 Chinese adults (736 men and 450 women) who underwent a health check-up at the Huadong Hospital Affiliated to Fudan University (Shanghai, China) between January 1, 2010 and July 31, 2018. Clinical and thyroid hormone levels were compared in different UA groups (in male and menopause women groups, MG1: UA < 5 mg/dL; MG2: 5 mg/dL ≤ UA< 7 mg/dL; and MG3: UA ≥ 7 mg/dL; in female groups, FG1 to FG3 represent the UA levels of
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Assessment of circulating tumor DNA in cerebrospinal fluid by whole exome
           sequencing to detect genomic alterations of glioblastoma

    • Authors: Duan; Hao; Hu, Ji-Long; Chen, Zheng-He; Li, Jue-Hui; He, Zhen-Qiang; Wang, Zhen-Ning; Zhang, Guan-Hua; Guo, Xiao-Yu; Liang, Lun; Mou, Yong-Gao
      Abstract: imageBackground Cerebrospinal fluid (CSF) has been demonstrated as a better source of circulating tumor DNA (ctDNA) than plasma for brain tumors. However, it is unclear whether whole exome sequencing (WES) is qualified for detection of ctDNA in CSF. The aim of this study was to determine if assessment of ctDNA in CSF by WES is a feasible approach to detect genomic alterations of glioblastoma.Methods CSFs of ten glioblastoma patients were collected pre-operatively at the Department of Neurosurgery, Sun Yat-sen University Cancer Center. ctDNA in CSF and genome DNA in the resected tumor were extracted and subjected to WES. The identified glioblastoma-associated mutations from ctDNA in CSF and genome DNA in the resected tumor were compared.Results Due to the ctDNA in CSF was unqualified for exome sequencing for one patient, nine patients were included into the final analysis. More glioblastoma-associated mutations tended to be detected in CSF compared with the corresponding tumor tissue samples (3.56 ± 0.75 vs. 2.22 ± 0.32, P = 0.097), while the statistical significance was limited by the small sample size. The average mutation frequencies were similar in CSF and tumor tissue samples (74.1% ± 6.0% vs. 73.8% ± 6.0%, P = 0.924). The R132H mutation of isocitrate dehydrogenase 1 and the G34V mutation of H3 histone, family 3A (H3F3A) which had been reported in the pathological diagnoses were also detected from ctDNA in CSF by WES. Patients who received temozolomide chemotherapy previously or those whose tumor involved subventricular zone tended to harbor more mutations in their CSF.Conclusion Assessment of ctDNA in CSF by WES is a feasible approach to detect genomic alterations of glioblastoma, which may provide useful information for the decision of treatment strategy.
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • One-stop strategy for treatment of atrial fibrillation: feasibility and
           safety of combining catheter ablation and left atrial appendage closure in
           a single procedure

    • Authors: Chen; Mu; Wang, Zhi-Quan; Wang, Qun-Shan; Sun, Jian; Zhang, Peng-Pai; Feng, Xiang-Fei; Li, Wei; Yu, Ying; Liu, Bo; Mo, Bin-Feng; Zhang, Rui; Yang, Mei; Gong, Chang-Qi; Zhao, Ming-Zhe; Yu, Yi-Chi; Zhao, Yan; Lu, Qiu-Fen; Li, Yi-Gang
      Abstract: imageBackground Catheter ablation is effective in restoring sinus rhythm and left atrial appendage closure (LAAC) is increasingly used for stroke prevention in patients with atrial fibrillation (AF). We aimed to observe the feasibility and safety of performing AF ablation and LAAC in a single (one-stop) procedure.Methods Consecutive AF patients who underwent the combined procedure of AF ablation and LAAC with WATCHMAN device between March 2017 and September 2018 were prospectively enrolled. Baseline and intra-procedural parameters were evaluated. Three-month and subsequent 1-year follow-up were performed in all and earlier-enrolled subjects, respectively.Results A total of 178 AF patients (94 males, 68.9 ± 8.1 years) underwent the one-stop procedure with CHA2DS2-VASc score 3.3 ± 1.5 and HAS-BLED score 1.6 ± 1.0, respectively. Pulmonary vein isolation was achieved in all patients while additional linear ablation was applied if the operator deemed necessary, yielding immediate ablation success rate of 98.9% (176/178). In the subsequent LAAC, satisfactory seal (residual leak
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Thromboxane A2 receptor contributes to the activation of rat pancreatic
           stellate cells induced by 8-epi-prostaglandin F2α

    • Authors: Zhang; Xiao-Li; Li, Fei; Cui, Ye-Qing; Liu, Shuang; Sun, Hai-Chen
      Abstract: imageBackground Pancreatic stellate cells (PSCs) activation plays a critical role in the development of chronic pancreatitis. Previous studies confirmed that thromboxane A2 receptor (TxA2r) was overexpressed in activated PSCs in rats. The purpose of this study was to investigate the role of TxA2r in the activation of PSCs induced by 8-epi-prostaglandin F2α (8-epi-PGF2α).Methods TxA2r expression in both quiescent and activated PSCs was detected by immunocytochemistry and immunoblot assay. Isolated PSCs were treated with 8-epi-PGF2α (10−6, 10−7, 10−8 mol/L) for 48 h, and SQ29548 (10−4, 10−6, and 10−7 mol/L), a TxA2r-specific antagonist for 48 h, respectively, to identify the drug concentration with the best biological effect and the least cytotoxicity. Then isolated PSCs were treated with SQ29548 (10−4 mol/L) for 2 h, followed by 10−7 mol/L 8-epi-PGF2α for 48 h. Real-time polymerase chain reaction was performed to detect the messenger RNA (mRNA) levels of α-smooth muscle actin (α-SMA) and collagen I. Comparisons between the groups were performed using Student's t test.Results TxA2r was up-regulated in activated PSCs in vitro compared with quiescent PSCs (all P 
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Salvianolic acid B decreases interleukin-1β-induced colitis
           recurrence in mice

    • Authors: Feng; Pan-Pan; Fang, Xue-Sheng; Zhao, Si-Hui; Fu, Jun-Yan; Zhang, Hui-Ting; Yi, Yan-Lin; Li, Chang-Yi; Jiang, Chun-Ling; Chen, Da-Peng
      Abstract: imageBackground Degree of mucosal recovery is an important indicator for evaluating the therapeutic effects of drugs in treatment of inflammatory bowel disease (IBD). Increasing evidences has proved that tight junction (TJ) barrier dysfunction is one of the pathological mechanisms of IBD. The aim of this study was to observe whether enhancement of TJ can decrease colitis recurrence.Methods Eighty C57BL/6 mice were randomly divided into four groups including normal group, colitis group, sulfasalazine (SASP) treated group, and traditional Chinese drug salvianolic acid B (Sal B) treated group. Colitis was established in mice by free drinking water containing dextran sulfate sodium, after treatments by SASP and Sal B, recombinant human interleukin-1β (IL-1β) was injected intraperitoneally to induce colitis recurrence.Results Compared with sham control, cell apoptosis in colitis group was increased from 100.85 ± 3.46% to 162.89 ± 11.45% (P = 0.0038), and TJ dysfunction marker myosin light chain kinase (MLCK) was also significantly increased from 99.70 ± 9.29% to 296.23 ± 30.78% (P = 0.0025). The increased cell apoptosis was reversed by both SASP (125.99 ± 8.45% vs. 162.89 ± 11.45%, P = 0.0059) and Sal B (104.27 ± 6.09% vs. 162.89 ± 11.45%, P = 0.0044). High MLCK expression in colitis group was reversed by Sal B (182.44 ± 89.42% vs. 296.23 ± 30.78%, P = 0.0028) but not influenced by SASP (285.23 ± 41.04% vs. 296.23 ± 30.78%, P > 0.05). The recurrence rate induced by recombinant human IL-1β in Sal B-treated group was significantly lower than that in SASP-treated group.Conclusions These results suggested a link between intestinal mucosal barrier dysfunction, especially TJ barrier dysfunction, and colitis recurrence. The TJ barrier dysfunction in remission stage of colitis increased the colitis recurrence. This study might provide potential treatment strategies for IBD recurrence.
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Chinese expert consensus statement on metformin in clinical practice

    • Authors: Expert Group of Metformin in Clinical Practice
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Positron emission computed tomography/single photon emission computed
           tomography in Parkinson disease

    • Authors: Yao; Nian-Ting; Zheng, Qian; Xu, Zi-Qian; Yin, Jian-Hong; Lu, Lin-Guang; Zuo, Qi; Yang, Su; Zhang, Chun-Lin; Jiao, Ling
      Abstract: imageParkinson disease (PD) is the second-most common neurodegenerative disorder. Its main pathological mechanism is the selective degeneration and deletion of dopaminergic neurons in the dense part of the substantia nigra and the damage of dopaminergic neurons caused by the abnormal deposition of a Lewy body, leading to a decreased dopamine level. Positron emission computed tomography (PET)/single photon emission computed tomography (SPECT) is a molecular imaging technology that can directly or indirectly reflect changes in molecular levels by using a specific tracer. With the research and development on the tracers of related enzymes for labeling dopamine transporter and dopamine receptor and for being involved in dopamine formation, this imaging technology has been applied to all aspects of PD research. It not only contributes to clinical work but also provides an important theoretical basis for exploring the pathological mechanism of PD at a molecular level. Therefore, this review discusses the application value of PET/SPECT in PD in terms of early diagnosis, disease severity evaluation, clinical manifestations, differential diagnosis, and pathological mechanism.
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Sclerostin regulation: a promising therapy for periodontitis by modulating
           alveolar bone

    • Authors: Li; Tian-Jiao; Wang, Rui; Li, Qin-Yang; Li, Chun-Yu; Jiang, Li
      Abstract: imagePeriodontitis is one of the most prevalent epidemics affecting human health and life recently, and exploration of the pathogenesis and treatment of periodontitis has been valued by scholars. In recent years, sclerostin, a new factor on bone resorption and reconstruction caused by inflammation and mechanical stimulation, has been a research hotspot. This article summarizes the researches on sclerostin in periodontitis development in recent years. Among them, sclerostin has been shown to be a critical negative regulator of bone formation, thereby inhibiting bone remodeling in periodontitis development, and is closely associated with tooth movement. Besides, evidence indicates that the removal of sclerostin seems to reasonably protect the alveolar bone from resorption. Regulation of sclerostin expression is a novel, promising treatment for periodontitis and addresses several complications seen with traditional therapies; accordingly, many drugs with similar mechanisms have emerged. Moreover, the application prospect of sclerostin in periodontal therapy combined with orthodontic treatment is another promising approach. There are also a lot of drugs that regulate sclerostin. Anti-sclerostin antibody (Scl-Ab) is the most direct one that inhibits bone resorption caused by sclerostin. At present, drugs that inhibit the expression of sclerostin have been applied to the treatment of diseases such as multiple myeloma and osteoporosis. Therefore, the application of sclerostin in the oral field is just around the corner, which provides a new therapeutic bone regulation strategy in oral and general health.
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Primary central nervous system lymphoma: status and advances in diagnosis,
           molecular pathogenesis, and treatment

    • Authors: Zhang; Yan; Zhou, Dao-Bin
      Abstract: imagePrimary central nervous system lymphoma (PCNSL) is a rare group of extra-nodal non-Hodgkin lymphoma which is confined to the central nervous system or eyes. This article aims to present a brief profile of PCNSL diagnosis and treatment in immunocompetent patients. The authors retrieved information from the PubMed database up to September 2019. The annual incidence of PCNSL increased over the last four decades. The prognosis of PCNSL has improved mainly due to the introduction and wide-spread use of high-dose methotrexate, which is now the backbone of all first-line treatment polychemotherapy regimens. Gene expression profiling and next-generation sequencing analyses have revealed mutations that induce activation of nuclear factor-κB, B cell antigen receptor, and Janus kinases/signal transducer and activator of transcription proteins signal pathways. Some novel agents are investigated in the treatment of relapsed PCNSL including immunotherapy and targeted therapy. In particular, lenalidomide and ibrutinib have demonstrated durable efficiency. Treatment of PCNSL has evolved in the last 40 years and survival outcomes have improved in most patient groups, but there is still room to improve outcome by optimizing current chemotherapy and novel agents.
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Current therapies for patients with acute exacerbation of idiopathic
           pulmonary fibrosis

    • Authors: Zhu; Li-Li; Dai, Hua-Ping; Wang, Chen
      Abstract: No abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Development and evaluation of psychometric properties of a common module
           for the quality of life scale of living organ donors (QLSLOD-CM V1.0)
           based on liver donors

    • Authors: Shi; Yue-Xian; Zhang, Hai-Ming; Chen, Jing; Li, Hao-Hao; Yu, Ming-Ming; Jin, Yin-Hui; Huang, Ya-Qi; Sun, Meng; Gao, Wei; Shang, Shao-Mei
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Effect of high-dose ulinastatin on the cardiopulmonary bypass-induced
           inflammatory response in patients undergoing open-heart surgery

    • Authors: Liu; Yu; Wang, Ying-Lin; Zou, Shao-Hua; Sun, Peng-Fei; Zhao, Quan
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Detection of serum immunoglobulin M and immunoglobulin G antibodies in
           2019 novel coronavirus infected patients from different stages

    • Authors: Gao; Hui-Xia; Li, Ya-Nan; Xu, Zun-Gui; Wang, Yu-Ling; Wang, Hai-Bin; Cao, Jin-Feng; Yuan, De-Qin; Li, Li; Xu, Yi; Zhang, Zhi; Huang, Ying; Lu, Jian-Hua; Liu, Yu-Zhen; Dai, Er-Hei
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Reversible renal infarctions associated with pheochromocytoma: a case
           report

    • Authors: Liu; Lu; Qiu, Jian-Xing; Gao, Ying; Tian, Jie; Zhang, Zheng; Zhang, Jun-Qing; Guo, Xiao-Hui
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Substantia nigra hyperechogenicity in Parkinson disease patients with
           leucine-rich repeat kinase 2 variants in the Chinese Han population

    • Authors: Li; Kai; Gu, Chen-Chen; Zhang, Jin-Ru; Jin, Hong; Ge, Yi-Lun; Chen, Jing; Yang, Ya-Ping; Wang, Fen; Mao, Cheng-Jie; Zhang, Ying-Chun; Liu, Chun-Feng
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Molecular diagnostic practices for infectious gastroenteritis

    • Authors: Shen; Nan; Tao, Yue; Du, Bai-Lu; Cao, Qing
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • A case of coronavirus disease 2019 with twice negative nucleic acid
           testing within 8 days

    • Authors: Ruan; Zhong-Rui; Gong, Peng; Han, Wei; Huang, Min-Qiang; Han, Ming
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Advances in the relationship between coronavirus infection and coagulation
           function

    • Authors: Zou; Hai; Xiong, Wan-Feng
      Abstract: No abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Analysis of the evolutionary path and hotspots of innate lymphoid cells
           based on a knowledge map

    • Authors: Liu; Ying; Zeng, Zuo-Jing; Peng, Shun-Lin
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • A report on the syndrome of inappropriate anti-diuretic hormone secretion
           associated with multiple myeloma

    • Authors: Tang; Ran; Zhang, Jia-Jia; Zhong, Yu-Ping
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Cholangiocarcinoma presenting with acquired thrombotic thrombocytopenic
           purpura confirmed by positive autoantibodies of a disintegrin and
           metalloproteinase with a thrombospondin type 1 motif, member 13

    • Authors: Li; Yue-Ting; Du, Han-Ze; Wang, Chun-Yao; Zhu, Tie-Nan; Pan, Bo-Ju; Zhang, Lu
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Lessons from transulnar access for repeat percutaneous coronary
           intervention after radial artery occlusion

    • Authors: Bi; Xi-Le; Wang, Qing-Sheng
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Systemic lupus erythematosus induced by adjuvants after
           metal-on-polyethylene total hip arthroplasty

    • Authors: Wang; Chang-Chao; Huang, Yan; Huang, Ya-Dong
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Bronchoscopic intervention for a patient with bronchial mucoepidermoid
           carcinoma

    • Authors: Zhang; Qun-Cheng; Ouyang, Wen-Juan; Zhang, Xiao-Ju
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • A rare case of pigmented Bowen disease of the nail fold

    • Authors: Pradhan; Sushmita; Xue, Si-Liang
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Asialoglycoprotein receptor 1 gene expression in peripheral blood
           monocytes associates with serum total cholesterol and low-density
           lipoprotein cholesterol levels

    • Authors: Zhao; Xiang; Tang, Bin; Shi, Zhi-Hua; Deng, Zi-Wei; Deng, Ye; Tan, Li-Ming; Jiang, Shi-Long; Shu, Yuan-Lu; Qiu, Cheng-Feng
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Follow-up in hepatic alveolar echinococcosis under benzimidazole therapy
           using computed tomography

    • Authors: Graeter; Tilmann; Shi, Rong; Bao, Hai-Hua; Kratzer, Wolfgang; Barth, Thomas F.E.; Hillenbrand, Andreas; Henne-Bruns, Doris; Schmidberger, Julian; Gruener, Beate; Li, Wei-Xia; for the Echinococcosis Study Group Ulm
      Abstract: No abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
  • Pharmacokinetics of Hu-Pi-Cheng-Qi decoction administered via enema to
           rats with acute pancreatitis

    • Authors: Wu; Qiu-Ting; Chen, Huan; Xiang, Jin; Tang, Wen-Fu; Wan, Mei-Hua
      Abstract: imageNo abstract available
      PubDate: Sat, 20 Jun 2020 00:00:00 GMT-
       
 
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