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Publisher: Medknow Publishers   (Total: 429 journals)

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Showing 1 - 200 of 429 Journals sorted alphabetically
Acta Medica Intl.     Open Access   (SJR: 0.101, CiteScore: 0)
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advanced Biomedical Research     Open Access  
Advances in Human Biology     Open Access   (Followers: 3)
Advances in Skeletal Muscle Function Assessment     Open Access  
African J. for Infertility and Assisted Conception     Open Access  
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.25, CiteScore: 1)
African J. of Trauma     Open Access   (Followers: 1)
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Alexandria J. of Pediatrics     Open Access  
Ancient Science of Life     Open Access   (Followers: 5)
Anesthesia : Essays and Researches     Open Access   (Followers: 10)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.258, CiteScore: 1)
Annals of Bioanthropology     Open Access   (Followers: 4)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.308, CiteScore: 1)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery     Open Access  
Annals of Indian Psychiatry     Open Access  
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 7, SJR: 0.352, CiteScore: 1)
Annals of Saudi Medicine     Open Access   (SJR: 0.238, CiteScore: 1)
Annals of Thoracic Medicine     Open Access   (Followers: 5, SJR: 0.524, CiteScore: 1)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 12, SJR: 0.152, CiteScore: 0)
Annals of Tropical Pathology     Open Access  
Apollo Medicine     Open Access  
APOS Trends in Orthodontics     Open Access  
Arab J. of Interventional Radiology     Open Access  
Archives of Cardiovascular Imaging     Open Access   (Followers: 1, SJR: 0.187, CiteScore: 0)
Archives of Intl. Surgery     Open Access   (Followers: 10, SJR: 0.302, CiteScore: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Medicine and Surgery     Open Access  
Archives of Pharmacy Practice     Open Access   (Followers: 6, SJR: 0.102, CiteScore: 0)
Archives of Trauma Research     Open Access   (Followers: 3, SJR: 0.37, CiteScore: 2)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 4)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.856, CiteScore: 2)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.35, CiteScore: 1)
Asian Pacific J. of Reproduction     Open Access   (SJR: 0.227, CiteScore: 1)
Asian Pacific J. of Tropical Biomedicine     Open Access   (Followers: 2, SJR: 0.491, CiteScore: 2)
Asian Pacific J. of Tropical Medicine     Open Access   (Followers: 1, SJR: 0.561, CiteScore: 2)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
Biomedical and Biotechnology Research J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Canadian J. of Rural Medicine     Full-text available via subscription   (SJR: 0.202, CiteScore: 0)
Cancer Translational Medicine     Open Access   (Followers: 2)
Cardiology Plus     Open Access  
Chinese Medical J.     Open Access   (Followers: 10, SJR: 0.52, CiteScore: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Cancer Investigation J.     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 2)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 10, SJR: 0.811, CiteScore: 2)
Contemporary Clinical Dentistry     Open Access   (Followers: 4, SJR: 0.353, CiteScore: 1)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.543, CiteScore: 1)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.152, CiteScore: 0)
Dental Research J.     Open Access   (Followers: 11, SJR: 0.416, CiteScore: 1)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 6, SJR: 0.242, CiteScore: 0)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1, SJR: 1.799, CiteScore: 2)
Egyptian J. of Chest Diseases and Tuberculosis     Open Access   (Followers: 3, SJR: 0.155, CiteScore: 0)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.127, CiteScore: 0)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Nursing J.     Open Access  
Egyptian Orthopaedic J.     Open Access   (Followers: 2)
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.822, CiteScore: 2)
Environmental Disease     Open Access   (Followers: 2)
Eurasian J. of Pulmonology     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.749, CiteScore: 2)
European J. of General Dentistry     Open Access   (Followers: 1, SJR: 0.12, CiteScore: 0)
European J. of Prosthodontics     Open Access   (Followers: 3)
European J. of Psychology and Educational Studies     Open Access   (Followers: 11, SJR: 0.113, CiteScore: 0)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.112, CiteScore: 0)
Genome Integrity     Open Access   (Followers: 3, SJR: 0.153, CiteScore: 0)
Glioma     Open Access  
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Gynecology and Minimally Invasive Therapy     Open Access   (SJR: 0.311, CiteScore: 1)
Hamdan Medical J.     Open Access  
Heart and Mind     Open Access  
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
Ibnosina J. of Medicine and Biomedical Sciences     Open Access  
IJS Short Reports     Open Access  
Imam J. of Applied Sciences     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.478, CiteScore: 1)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (Followers: 1, SJR: 0.361, CiteScore: 1)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.37, CiteScore: 1)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.604, CiteScore: 1)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.266, CiteScore: 1)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.468, CiteScore: 1)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 5, SJR: 0.445, CiteScore: 1)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1, SJR: 0.791, CiteScore: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4, SJR: 0.568, CiteScore: 1)
Indian J. of Health Sciences     Open Access   (Followers: 3)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.425, CiteScore: 1)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.503, CiteScore: 1)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.656, CiteScore: 1)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.102, CiteScore: 0)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.347, CiteScore: 1)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.23, CiteScore: 0)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 3, SJR: 0.225, CiteScore: 1)
Indian J. of Ophthalmology     Open Access   (Followers: 4, SJR: 0.498, CiteScore: 1)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 8, SJR: 0.392, CiteScore: 1)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.199, CiteScore: 0)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.454, CiteScore: 1)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 2, SJR: 0.276, CiteScore: 1)
Indian J. of Pharmacology     Open Access   (SJR: 0.412, CiteScore: 1)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.311, CiteScore: 0)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.408, CiteScore: 1)
Indian J. of Psychological Medicine     Open Access   (SJR: 0.368, CiteScore: 1)
Indian J. of Public Health     Open Access   (Followers: 1)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Respiratory Care     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.119, CiteScore: 0)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.34, CiteScore: 0)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Transplantation     Open Access  
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Indian Spine J.     Open Access  
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intervention     Open Access   (Followers: 1)
Intl. Archives of Health Sciences     Open Access  
Intl. J. of Abdominal Wall and Hernia Surgery     Open Access  
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Clinicopathological Correlation     Open Access  
Intl. J. of Community Dentistry     Open Access  
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1, SJR: 0.192, CiteScore: 0)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 3, SJR: 0.142, CiteScore: 0)
Intl. J. of Growth Factors and Stem Cells in Dentistry     Open Access  
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 6)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.535, CiteScore: 1)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4, SJR: 0.17, CiteScore: 0)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 2)
Intl. J. of Orofacial Biology     Open Access  
Intl. J. of Orofacial Research     Open Access  
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.623, CiteScore: 1)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 5, SJR: 0.653, CiteScore: 1)
Intl. J. of the Cardiovascular Academy     Open Access   (SJR: 0.105, CiteScore: 0)
Intl. J. of Trichology     Open Access   (SJR: 0.4, CiteScore: 1)
Intl. J. of Yoga     Open Access   (Followers: 13)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 5)

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Journal Cover
Chinese Medical Journal
Journal Prestige (SJR): 0.52
Citation Impact (citeScore): 1
Number of Followers: 10  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0366-6999 - ISSN (Online) 2542-5641
Published by Medknow Publishers Homepage  [429 journals]
  • Glomerular Filtration Rate is Associated with Hemorrhagic Transformation
           in Acute Ischemic Stroke Patients without Thrombolytic Therapy

    • Authors: Ming-Su Liu, Yan Liao, Guang-Qin Li
      Pages: 1639 - 1644
      Abstract: Ming-Su Liu, Yan Liao, Guang-Qin Li
      Chinese Medical Journal 2018 131(14):1639-1644
      Background: Whether there is a relationship between glomerular filtration rate (GFR) and hemorrhagic transformation (HT) after acute ischemic stroke (AIS) is still under debate. The aim of our study was to determine whether the GFR level is a predictor of HT in AIS patients without thrombolytic therapy (TT).Methods: Consecutive AIS patients without TT were included in this prospective study from January 2014 to December 2016 in the First Affiliated Hospital of Chongqing Medical University. We divided them into two groups (HT and non-HT group) and meticulously collected baseline characteristics and laboratory and imaging data of interested individuals. Multivariate regression analysis was performed to assess the correlation between GFR and HT in stroke patients without TT.Results: Among 426 consecutive patients, 74 (17.3%) presented HT (mean age: 65 ± 12 years, number of male patients: 47) on the follow-up scans. In multivariate regression analysis, HT was significantly associated with low GFR (odds ratio [OR] = 3.708, confidence interval [CI] = 1.326–10.693, P = 0.013), atrial fibrillation (AF; OR = 2.444, CI = 1.087–5.356, P = 0.027), large cerebral infarction (OR = 2.583, CI = 1.236–5.262, P = 0.010), and hypoalbuminemia (HA; OR = 4.814, CI = 1.054–22.153, P = 0.037) for AIS patients without TT.Conclusions: The present study strongly showed that lower GFR is an independently predictor of HT; in addition, large infarct volume, AF, and HA are also important risks of HT for AIS patients without TT, which offered a practical information that risk factors should be paid attention or eliminated to prevent HT for stroke patients though the level of evidence seems to be unstable.
      Citation: Chinese Medical Journal 2018 131(14):1639-1644
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235873
      Issue No: Vol. 131, No. 14 (2018)
       
  • Efficacy of Pegylated Interferon Monotherapy versus Sequential Therapy of
           Entecavir and Pegylated Interferon in Hepatitis B e Antigen-Positive
           Hepatitis B Patients: A Randomized, Multicenter, Phase IIIb Open-Label
           Study (POTENT Study)

    • Authors: Dae Won Jun, Sang Bong Ahn, Tae Yeob Kim, Joo Hyun Sohn, Sang Gyune Kim, Se Whan Lee, Byung Ho Kim, Dong Joon Kim, Ja Kyung Kim, Hyoung Su Kim, Seong Gyu Hwang, Won Choong Choi, Won Young Tak, Heon Ju Lee, Ki Tae Yoon, Byung Cheol Yun, Sung Wook Lee, Soon Koo Baik, Seung Ha Park, Ji Won Park, Sol Ji Park, Ji Sung Lee
      Pages: 1645 - 1651
      Abstract: Dae Won Jun, Sang Bong Ahn, Tae Yeob Kim, Joo Hyun Sohn, Sang Gyune Kim, Se Whan Lee, Byung Ho Kim, Dong Joon Kim, Ja Kyung Kim, Hyoung Su Kim, Seong Gyu Hwang, Won Choong Choi, Won Young Tak, Heon Ju Lee, Ki Tae Yoon, Byung Cheol Yun, Sung Wook Lee, Soon Koo Baik, Seung Ha Park, Ji Won Park, Sol Ji Park, Ji Sung Lee
      Chinese Medical Journal 2018 131(14):1645-1651
      Background: Until now, various types of combined therapy with nucleotide analogs and pegylated interferon (Peg-INF) in patients with hepatitis B patients have been tried. However, studies regarding the benefits of de novo combination, late-add on, and sequential treatment are very limited. The objective of the current study was to identify the efficacy of sequential treatment of Peg-INF after short-term antiviral treatment.Methods: Between June 2010 and June 2015, hepatitis B e antigen (HBeAg)-positive patients (n = 162) received Peg-IFN for 48 weeks (mono-treatment group, n = 81) and entecavir (ETV) for 12 weeks with a 48-week course of Peg-IFN starting at week 5 of ETV therapy (sequential treatment group, n = 81). The primary endpoint was HBeAg seroconversion at the end of follow-up period after the 24-week treatment. The primary endpoint was analyzed using Chi-square test, Fisher's exact test, and regression analysis.Results: HBeAg seroconversion rate (18.2% vs. 18.2%, t = 0.03, P = 1.000) and seroclearance rate (19.7% vs. 19.7%, t = 0.03, P = 1.000) were same in both mono-treatment and sequential treatment groups. The rate of alanine aminotransferase (ALT) normalization (45.5% vs. 54.5%, t = 1.12, P = 0.296) and serum hepatitis B virus (HBV)-DNA <2000 U/L (28.8% vs. 28.8%, t = 0.10, P = 1.000) was not different in sequential and mono-treatment groups at 24 weeks of Peg-INF. Viral response rate (HBeAg seroconversion and serum HBV-DNA <2000 U/L) was not different in the two groups (12.1% vs. 16.7%, t = 1.83, P = 0.457). Baseline HBV-DNA level (7 log10U/ml vs. 7.5 log10U/ml, t = 1.70, P = 0.019) and hepatitis B surface antigen titer (3.6 log10U/ml vs. 4.0 log10U/ml, t = 2.19, P = 0.020) were lower and predictors of responder in mono-treatment and sequential treatment groups, respectively.Conclusions: The current study shows no differences in HBeAg seroconversion rate, ALT normalization, and HBV-DNA levels between mono-therapy and sequential therapy regimens.Trial Registration: ClinicalTrials.gov, NCT01220596; https://clinicaltrials.gov/ct2/show/NCT01220596?term=NCT01220596&rank=1.
      Citation: Chinese Medical Journal 2018 131(14):1645-1651
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235880
      Issue No: Vol. 131, No. 14 (2018)
       
  • Identification of Newly Diagnosed Diabetes and Prediabetes Using Fasting
           Plasma Glucose and Urinary Glucose in a Chinese Population: A Multicenter
           Cross-Sectional Study

    • Authors: Juan Chen, Hai Jian Guo, Shan-Hu Qiu, Wei Li, Xiao-Hang Wang, Min Cai, Bei Wang, Xiao-Ning Li, Zi-Lin Sun
      Pages: 1652 - 1657
      Abstract: Juan Chen, Hai Jian Guo, Shan-Hu Qiu, Wei Li, Xiao-Hang Wang, Min Cai, Bei Wang, Xiao-Ning Li, Zi-Lin Sun
      Chinese Medical Journal 2018 131(14):1652-1657
      Background: Although fasting plasma glucose (FPG) has been highly recommended as the sole test for diabetes screening, the efficacy of FPG alone for diabetes screening is potentially limited due to its low sensitivity. The aim of this study was to improve the efficacy of FPG for diabetes screening using urinary glucose (UG).Methods: This study was initiated on November 12, 2015, and ended on June 28, 2016. A representative sample of individuals aged between 18 and 65 years, with no history of diabetes, from 6 cities in Jiangsu Province participated in this study. A 75-g oral glucose tolerance test was used to diagnose diabetes. All urine samples were collected within 2 h of oral glucose loading to measure UG. Partial correlation analyses were used to evaluate the associations between UG and other glycemic variables, including FPG, 2-h plasma glucose (2h-PG), and glycated hemoglobin A1c, after adjustment for age. The performance of UG was evaluated using a receiver operating characteristic (ROC) curve analysis.Results: Of the 7485 individuals included, 8% were newly diagnosed with diabetes and 48.7% had prediabetes. The areas under the ROC curves for UG were 0.75 for estimation of 2h-PG ≥7.8 mmol/L and 0.90 for 2h-PG ≥11.1 mmol/L, respectively. The sensitivity and specificity of UG were 52.3% and 87.8%, respectively, for 2h-PG ≥7.8 mmol/L (cutoff point ≥130 mg), and 83.5% and 87.5%, respectively, for 2h-PG ≥11.1 mmol/L (cutoff point ≥178.5 mg). The combination of FPG and UG demonstrated a significantly higher sensitivity than that of FPG alone for the identification of diabetes ([483/597] 80.9% vs. [335/597] 56.1%, χ2 = 85.0, P < 0.001) and glucose abnormalities ([2643/4242] 62.3% vs. [2365/4242] 55.8%, χ2 = 37.7, P < 0.001).Conclusions: The combination of UG and FPG substantially improves the efficacy of using FPG alone for diabetes screening; this combination might be a practical screening tool and is worth being recommended in the future.
      Citation: Chinese Medical Journal 2018 131(14):1652-1657
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235884
      Issue No: Vol. 131, No. 14 (2018)
       
  • Clinical Analysis of 1593 Patients with Infectious Endophthalmitis: A
           12-Year Study at a Tertiary Referral Center in Western China

    • Authors: Xu-Bo Yang, Yuan-Yuan Liu, Zhi-Xuan Huang, Yu Mao, Li Zhao, Zhu-Ping Xu
      Pages: 1658 - 1665
      Abstract: Xu-Bo Yang, Yuan-Yuan Liu, Zhi-Xuan Huang, Yu Mao, Li Zhao, Zhu-Ping Xu
      Chinese Medical Journal 2018 131(14):1658-1665
      Background: Infectious endophthalmitis is a severe ocular inflammation which can cause devastating visual loss. The aim of the study was to identify the demographic and clinical features of infectious endophthalmitis in Western China for better prophylaxis and treatment of this disease.Methods: A retrospective, cross-sectional study was conducted based on the medical records of inpatients having infectious endophthalmitis in a tertiary referral center in Western China between 2005 and 2016.Results: The common cause of infectious endophthalmitis was trauma (82.6%), endogenous (7.8%), ophthalmic surgery (6.9%), and corneal ulcer with perforation (2.7%). These four etiological groups differed in age, gender, enucleation rate, visual outcome, etc. The number of cases in the first 6 years accounted for 38.7% of the total collection, which in the second 6 years accounted for 61.3%. The etiology patterns were different between these two periods. Altogether 51.3% of patients received pars plana vitrectomy, 13.9% of patients underwent evisceration, and the remaining 34.8% received other treatments. Of the 670 cases that had culture results, 266 (39.7%) were culture positive and 177 (66.5%) were Gram-positive organisms, 64 (24.1%) were Gram-negative organisms, 11 (4.1%) had fungal infection, and 14 (5.3%) were infected by multiple pathogens.Conclusions: There was an upward trend of the occurrence of infectious endophthalmitis in Western China for the past decade. The demographic and clinical characteristics of infectious endophthalmitis in Western China had its own characteristics and differed from those of developed countries. Here, open globe trauma was the most common cause of endophthalmitis, most traumatic endophthalmitis patients were male, and most of the injuries were work related, implicate that we should strengthen the education and application of ocular safety regulation specifically targeting the workplace.
      Citation: Chinese Medical Journal 2018 131(14):1658-1665
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235866
      Issue No: Vol. 131, No. 14 (2018)
       
  • Diagnostic Performance and Interobserver Consistency of the Prostate
           Imaging Reporting and Data System Version 2: A Study on Six Prostate
           Radiologists with Different Experiences from Half a Year to 17 Years

    • Authors: Zan Ke, Liang Wang, Xiang-De Min, Zhao-Yan Feng, Zhen Kang, Pei-Pei Zhang, Ba-Sen Li, Hui-Juan You, Sheng-Chao Hou
      Pages: 1666 - 1673
      Abstract: Zan Ke, Liang Wang, Xiang-De Min, Zhao-Yan Feng, Zhen Kang, Pei-Pei Zhang, Ba-Sen Li, Hui-Juan You, Sheng-Chao Hou
      Chinese Medical Journal 2018 131(14):1666-1673
      Background: One of the main aims of the updated Prostate Imaging Reporting and Data System Version 2 (PI-RADS v2) is to diminish variation in the interpretation and reporting of prostate imaging, especially among readers with varied experience levels. This study aimed to retrospectively analyze diagnostic consistency and accuracy for prostate disease among six radiologists with different experience levels from a single center and to evaluate the diagnostic performance of PI-RADS v2 scores in the detection of clinically significant prostate cancer (PCa).Methods: From December 2014 to March 2016, 84 PCa patients and 99 benign prostatic shyperplasia patients who underwent 3.0T multiparametric magnetic resonance imaging before biopsy were included in our study. All patients received evaluation according to the PI-RADS v2 scale (1–5 scores) from six blinded readers (with 6 months and 2, 3, 4, 5, or 17 years of experience, respectively, the last reader was a reviewer/contributor for the PI-RADS v2). The correlation among the readers' scores and the Gleason score (GS) was determined with the Kendall test. Intra-/inter-observer agreement was evaluated using κ statistics, while receiver operating characteristic curve and area under the curve analyses were performed to evaluate the diagnostic performance of the scores.Results: Based on the PI-RADS v2, the median κ score and standard error among all possible pairs of readers were 0.506 and 0.043, respectively; the average correlation between the six readers' scores and the GS was positive, exhibiting weak-to-moderate strength (r = 0.391, P = 0.006). The AUC values of the six radiologists were 0.883, 0.924, 0.927, 0.932, 0.929, and 0.947, respectively.Conclusion: The inter-reader agreement for the PI-RADS v2 among the six readers with different experience is weak to moderate. Different experience levels affect the interpretation of MRI images.
      Citation: Chinese Medical Journal 2018 131(14):1666-1673
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235872
      Issue No: Vol. 131, No. 14 (2018)
       
  • Natural History of Seroma Following the Immediate Latissimus Dorsi Flap
           Method of Breast Reconstruction

    • Authors: Wen-Hui Yan, Jian-Bo Mang, Li-Li Ren, Da-Lie Liu
      Pages: 1674 - 1679
      Abstract: Wen-Hui Yan, Jian-Bo Mang, Li-Li Ren, Da-Lie Liu
      Chinese Medical Journal 2018 131(14):1674-1679
      Background: The latissimus dorsi (LD) flap procedure remains a popular and useful breast reconstruction tool in China and Western countries, and donor site seroma formation is the main complication. This study was conducted in Chinese patients to determine whether stable cases of seromas would resolve without treatment.Methods: A retrospective review of 45 consecutive cases of immediate breast reconstruction with LD flap from April 2012 to February 2017 was conducted. The scope of the seroma was demarcated with a marker pen, and cases that remained stable over time (i.e. the size of the seroma did not increase) were observed without treatment. The measured outcomes included the incidence of seromas, the volume and duration of postoperative wound drainage, and other demographic characteristics.Results: Twenty-four patients (53.3%) developed a seroma at the donor site. Of these, 21 patients (87.5%) did not require treatment, and the seroma resolved over time. The mean duration of a sustained seroma was 6.8 ± 1.4 weeks (range: 4–9 weeks).Conclusions: This study observed the scope and progression of the seromas and found that seromas at the LD donor sites resolved over time without treatment.
      Citation: Chinese Medical Journal 2018 131(14):1674-1679
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235877
      Issue No: Vol. 131, No. 14 (2018)
       
  • Placement of a Jejunal Feeding Tube via an Ultrasound-Guided Antral
           Progressive Water Injection Method

    • Authors: Qing Zhang, Jian-Hua Sun, Jia-Tao Liu, Xiao-Ting Wang, Da-Wei Liu
      Pages: 1680 - 1685
      Abstract: Qing Zhang, Jian-Hua Sun, Jia-Tao Liu, Xiao-Ting Wang, Da-Wei Liu
      Chinese Medical Journal 2018 131(14):1680-1685
      Background: Jejunal feeding tube allows the nutrition of critical care patients more easy and safe. However, its placement remains a challenge. This study aimed to introduce a jejunal feeding tube through an ultrasound-guided antral progressive water injection method and subsequently to examine its efficacy.Methods: Between April 2016 and April 2017, 54 patients hospitalized in the Department of Critical Care Medicine, Peking Union Medical College Hospital, China who needed nutritional support through a jejunal feeding tube were recruited for this study. Patients who applied ultrasound-guided antral progressive water injection method were classified into the experimental group. Patients who applied conventional method were registered as control group.Results: No significant differences were found in age, body mass index, and Acute Physiology and Chronic Health Evaluation score, but a significant difference in operation time was found between the experimental group and the control group. Of the 24 individuals in the control group, 17 displayed clear catheter sound shadows once the tube entered the esophagus. In comparison, of the 30 individuals in the experimental group, all harbored catheter sound shadows through the esophageal gas injection method. Subsequent observation revealed that in the control group (via ultrasonographic observation), 15 individuals underwent successful antral tube entry, for a success rate of 63%. In the experimental group (via antral progressive water injection), 27 individuals underwent successful antral tube entry, for a success rate of 90%. There was a significant difference between the success rates of the two groups (χ2 = 5.834, P = 0.022).Conclusion: The antral progressive water injection method for the placement of a jejunal feeding tube is more effective than the traditional ultrasonic placement method.
      Citation: Chinese Medical Journal 2018 131(14):1680-1685
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235874
      Issue No: Vol. 131, No. 14 (2018)
       
  • Curcumin Inhibits Lipopolysaccharide-Induced Mucin 5AC Hypersecretion and
           Airway Inflammation via Nuclear Factor Erythroid 2-Related Factor 2

    • Authors: Xiao-Ping Lin, Cheng Xue, Jia-Min Zhang, Wei-Jing Wu, Xiao-Yang Chen, Yi-Ming Zeng
      Pages: 1686 - 1693
      Abstract: Xiao-Ping Lin, Cheng Xue, Jia-Min Zhang, Wei-Jing Wu, Xiao-Yang Chen, Yi-Ming Zeng
      Chinese Medical Journal 2018 131(14):1686-1693
      Background: Excess mucus production is an important pathophysiological feature of chronic inflammatory airway diseases. Effective therapies are currently lacking. The aim of the study was to evaluate the effects of curcumin (CUR) on lipopolysaccharide (LPS)-induced mucus secretion and inflammation, and explored the underlying mechanism in vivo and in vitro.Methods: For the in vitro study, human bronchial epithelial (NCI-H292) cells were pretreated with CUR or vehicle for 30 min, and then exposed to LPS for 24 h. Next, nuclear factor erythroid 2-related factor 2 (Nrf2) was knocked down with Nrf2 small interfering RNA (siRNA) to confirm the specific role of Nrf2 in mucin regulation of CUR in NCI-H292 cells. In vivo, C57BL/6 mice were randomly assigned to three groups (n = 7 for each group): control group, LPS group, and LPS + CUR group. Mice in LPS and LPS + CUR group were injected with saline or CUR (50 mg/kg) intraperitoneally 2 h before intratracheal instillation with LPS (100 μg/ml) for 7 days. Cell lysate and lung tissue were obtained to measured Mucin 5AC (MUC5AC) and Nrf2 mRNA and protein expression by a real-time polymerase chain reaction and Western blotting. Bronchoalveolar lavage fluid (BALF) was collected to enumerate total cells and neutrophils. Histopathological changes of the lung were observed. Data were analyzed by one-way analysis of variance. Student's t-test was used when two groups were compared.Results: CUR significantly decreased the expression of MUC5AC mRNA and protein in NCI-H292 cells exposed to LPS. This effect was dose dependent (2.424 ± 0.318 vs. 7.169 ± 1.785, t = 4.534, and 1.060 ± 0.197 vs. 2.340 ± 0.209, t = 7.716; both P < 0.05, respectively) and accompanied by increased mRNA and protein expression of Nrf2 (1.952 ± 0.340 vs. 1.142 ± 0.176, t = −3.661, and 2.010 ± 0.209 vs. 1.089 ± 0.132, t = −6.453; both P < 0.05, respectively). Furthermore, knockdown of Nrf2 with siRNA increased MUC5AC mRNA expression by 47.7%, compared with levels observed in the siRNA-negative group (6.845 ± 1.478 vs. 3.391 ± 0.517, t = −3.821, P < 0.05). Knockdown of Nrf2 with siRNA also markedly increased MUC5AC protein expression in NCI-H292 cells. CUR also significantly decreased LPS-induced mRNA and protein expression of MUC5AC in mouse lung (1.672 ± 0.721 vs. 5.961 ± 2.452, t = 2.906, and 0.480 ± 0.191 vs. 2.290 ± 0.834, t = 3.665, respectively; both P < 0.05). Alcian blue/periodic acid-Schiff staining also showed that CUR suppressed mucin production. Compared with the LPS group, the numbers of inflammatory cells (247 ± 30 vs. 334 ± 24, t = 3.901, P < 0.05) and neutrophils (185 ± 22 vs. 246 ± 20, t = 3.566, P < 0.05) in BALF decreased in the LPS + CUR group, as well as reduced inflammatory cell infiltration in lung tissue.Conclusion: CUR inhibits LPS-induced airway mucus hypersecretion and inflammation through activation of Nrf2 possibly.
      Citation: Chinese Medical Journal 2018 131(14):1686-1693
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235863
      Issue No: Vol. 131, No. 14 (2018)
       
  • Effect of Dandelion Extracts on the Proliferation of Ovarian Granulosa
           Cells and Expression of Hormone Receptors

    • Authors: Tong Wang, Bing Xue, Hui Shao, Shu-Yu Wang, Li Bai, Cheng-Hong Yin, Huan-Ying Zhao, Yong-Chao Qi, Le-Le Cui, Xin He, Yan-Min Ma
      Pages: 1694 - 1701
      Abstract: Tong Wang, Bing Xue, Hui Shao, Shu-Yu Wang, Li Bai, Cheng-Hong Yin, Huan-Ying Zhao, Yong-Chao Qi, Le-Le Cui, Xin He, Yan-Min Ma
      Chinese Medical Journal 2018 131(14):1694-1701
      Background: In the current society, infertility related to age has become a social problem. The in vitro fertilization (IVF) success rate in women with poor ovarian response (POR) is very low. Dandelion extract T-1 (DE-T1) is an effective component of the extract from the leaves and stems of Taraxacum officinale, which is one of the medicines used in some patients with POR, but its molecular mechanism remains unclear.Methods: Following IVF, ovarian granulosa cells (GCs) of sixty patients were extracted and divided into normal ovarian response (NOR) and POR groups. GCs were cultured in a dose-dependent and time-dependent manner with DE-T1, proliferation of GCs was determined by Cell Counting Kit-8 assay, and mRNA levels of insulin-like growth factor 1 receptor (IGF-1R), luteotropic hormone receptor (LHR), follicle-stimulating hormone receptor (FSHR), LHR, and CYP19A1 (aromatase) were determined by quantitative polymerase chain reaction. Progesterone and estradiol (E2) concentrations were determined by enzyme-linked immunosorbent assay.Results: The cell viability gradually increased with the progressive increase in the DE-T1 concentration. Compared with the control group (without DE-T1), the mRNA expressions of FSHR, LHR, IGF-1R, and CYP19A1 were upregulated after the addition of DE-T1, especially in the 2.5% DE-T1 group (P < 0.01). The expression of IGF-1R was upregulated approximately 25 times (24.97 ± 4.02 times) in the POR group with 2.5% DE-T1. E2 and progesterone levels increased with the increasing DE-T1 concentration. There were highly significant differences in the E2 and progesterone secretion between the NOR and POR groups (P < 0.01).Conclusion: DE-T1 may promote steroid hormone synthesis by promoting GC proliferation and upregulating GC receptor expression, thereby improving ovarian endocrine function.
      Citation: Chinese Medical Journal 2018 131(14):1694-1701
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235864
      Issue No: Vol. 131, No. 14 (2018)
       
  • Effect of Autophagy Inhibition on the Protection of Ischemia
           Preconditioning against Myocardial Ischemia/Reperfusion Injury in Diabetic
           Rats

    • Authors: Ya-Yang Liu, Chao Sun, Fu-Shan Xue, Gui-Zhen Yang, Hui-Xian Li, Qing Liu, Xu Liao
      Pages: 1702 - 1709
      Abstract: Ya-Yang Liu, Chao Sun, Fu-Shan Xue, Gui-Zhen Yang, Hui-Xian Li, Qing Liu, Xu Liao
      Chinese Medical Journal 2018 131(14):1702-1709
      Background: Ischemia preconditioning (IPC) remains the most powerful intervention of protection against myocardial ischemia/reperfusion injury (IRI), but diabetes can weaken or eliminate its cardioprotective effect and detailed mechanisms remain unclear. In this study, we aimed to explore whether changes of autophagy in the diabetic condition are attributable to the decreased cardioprotective effect of IPC.Methods: Sixty diabetic male Sprague-Dawley rats were randomly divided into the control (C), IRI, rapamycin (R), wortmannin (W), rapamycin + IPC (R + IPC), and wortmannin + IPC (W + IPC) groups. The in vivo rat model of myocardial IRI was established by ligaturing and opening the left anterior descending coronary artery via the left thoracotomy. Durations of ischemia and reperfusion are 30 min and 120 min, respectively. Blood samples were taken at 120 min of reperfusion for measuring serum concentrations of troponin I (TnI) and creatine kinase isoenzyme MB (CK-MB) using the enzyme-linked immunosorbent assay. The infarct size was assessed by Evans blue and triphenyltetrazolium chloride staining. The expressions of LC3-II, beclin-1, phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and P-Akt/Akt ratio in the ischemic myocardium were assessed by Western blotting.Results: Compared to the IRI group, infarct size (56.1% ± 6.1% vs. 75.4 ± 7.1%, P < 0.05), serum cTnI (0.61 ± 0.21 vs. 0.95 ± 0.26 ng/ml, P < 0.05), and CK-MB levels (6.70 ± 1.25 vs. 11.51 ± 2.35 ng/ml, P < 0.05) obviously decreased in the W + IPC group. Compared with the C group, myocardial expressions of LC3-II (0.46 ± 0.04 and 0.56 ± 0.04 vs. 0.36 ± 0.04, P < 0.05) and beclin-1 (0.34 ± 0.08 and 0.38 ± 0.07 vs. 0.24 ± 0.03, P < 0.05) evidently increased, and myocardial expressions of mTOR (0.26 ± 0.08 and 0.25 ± 0.07 vs. 0.38 ± 0.06, P < 0.05), PI3K (0.29 ± 0.04 and 0.30 ± 0.03 vs. 0.38 ± 0.02, P < 0.05), and P-Akt/Akt ratio (0.49 ± 0.10 and 0.48 ± 0.06 vs. 0.72 ± 0.07, P < 0.05) markedly decreased in the IRI and R groups, indicating an increased autophagy. Compared with the IRI group, myocardial expression of beclin-1 (0.26 ± 0.03 vs. 0.34 ± 0.08, P < 0.05) significantly decreased, and myocardial expressions of mTOR (0.36 ± 0.04 vs. 0.26 ± 0.08, P < 0.05), PI3K (0.37 ± 0.03 vs. 0.29 ± 0.04, P < 0.05), and P-Akt/Akt ratio (0.68 ± 0.05 vs. 0.49 ± 0.10, P < 0.05) increased obviously in the W + IPC group, indicating a decreased autophagy.Conclusions: Increased autophagy in the diabetic myocardium is attributable to decreased cardioprotection of IPC, and autophagy inhibited by activating the PI3K-Akt-mTOR signaling pathway can result in an improved protection of IPC against diabetic myocardial IRI.
      Citation: Chinese Medical Journal 2018 131(14):1702-1709
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235867
      Issue No: Vol. 131, No. 14 (2018)
       
  • Constructing a Novel Three-Dimensional Biomimetic Corneal Endothelium
           Graft by Culturing Corneal Endothelium Cells on Compressed Collagen Gels

    • Authors: Yu-Jie Cen, Yun Feng
      Pages: 1710 - 1714
      Abstract: Yu-Jie Cen, Yun Feng
      Chinese Medical Journal 2018 131(14):1710-1714
      Background: Endothelium allotransplantation is the primary treatment for corneal decompensation. The worldwide shortage of donor corneal tissue has led to increasing pressure to seek an alternative for surgical restoration of corneal endothelium. Compressed collagen (CC) gels have excellent biocompatibility, simple preparation course and easy to be manipulated. This study aimed to form a new biomimetic endothelium graft by CC.Methods: We expanded bovine corneal endothelial cells (B-CECs) on laminin-coated CC to form a biomimetic endothelium graft. Scanning electron microscope was used for ultrastructural analysis and tight junction protein ZO-1 expression was tested by immunohistochemistry.Results: The biomimetic endothelium graft, we conducted had normal cell morphology, ultrastructure and higher cell density (3612.2 ± 43.4 cells/mm2). ZO-1 localization at B-CECs membrane indicated the bioengineered graft possess the basic endothelium function.Conclusions: A biomimetic endothelium graft with B-CECs expanded on CC sheet was constructed, which possessed cells' morphology similar to that of in vivo endothelial cells and specific basic function of endothelium layer. This method provided the possibility of using one donor's cornea to form multiple uniformed endothelium grafts so as to overcome the shortage of cadaveric cornea tissue.
      Citation: Chinese Medical Journal 2018 131(14):1710-1714
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235883
      Issue No: Vol. 131, No. 14 (2018)
       
  • Inhibitory Effects of Sulfur Dioxide on Rat Myocardial Fibroblast
           Proliferation and Migration

    • Authors: Lu-Lu Zhang, Jun-Bao Du, Chao-Shu Tang, Hong-Fang Jin, Ya-Qian Huang
      Pages: 1715 - 1723
      Abstract: Lu-Lu Zhang, Jun-Bao Du, Chao-Shu Tang, Hong-Fang Jin, Ya-Qian Huang
      Chinese Medical Journal 2018 131(14):1715-1723
      Background: Myocardial fibrosis is an important pathological change in many heart diseases, but its pathogenesis is very complex and has not yet been fully elucidated. The study was designed to examine whether endogenous sulfur dioxide (SO2) is a novel myocardial fibroblast proliferation and migration inhibitor.Methods: Primary rat myocardial fibroblasts were isolated and transfected with aspartate aminotransferase (AAT1 and AAT2) knockdown lentivirus or empty lentivirus. SO2 content in the supernatant was determined with high-performance liquid chromatography, and the expressions of AAT1, AAT2, proliferating cell nuclear antigen (PCNA), phosphorylated extracellular signal-regulated protein kinase (p-ERK), and total ERK (T-ERK) in the cells were detected. Cell migration was detected by wound healing test. Independent sample t-test (for two groups) and one-way analysis of variance (three or more groups) were used to analyze the results.Results: Both AAT1 and AAT2 knockdown significantly reduced SO2levels (F = 31.46, P < 0.01) and AAT1/2 protein expression (AAT1, t = 12.67, P < 0.01; AAT2, t = 9.61, P < 0.01), but increased PCNA expression and Cell Counting Kit-8 (CCK-8) activity as well as the migration in rat primary myocardial fibroblasts (P < 0.01). Supplementation of SO2rather than pyruvate significantly inhibited the increase in proliferation and migration caused by AAT knockdown (P < 0.01). Mechanistically, the ratio of p-ERK to T-ERK was significantly increased in the AAT1/2 knockdown groups compared with that in the empty lentivirus group (AAT1, t = −7.36, P < 0.01; AAT2, t = −10.97, P < 0.01). Whereas PD98059, an inhibitor of ERK activation, successfully blocked AAT knockdown-induced PCNA upregulation (F = 74.01, P > 0.05), CCK-8 activation (F = 50.14, P > 0.05), and migration augmentation in myocardial fibroblasts (24 h, F = 37.08, P > 0.05; 48 h, F = 58.60, P > 0.05).Conclusion: Endogenous SO2might be a novel myocardial fibroblast proliferation and migration inhibitor via inhibiting the ERK signaling pathway.
      Citation: Chinese Medical Journal 2018 131(14):1715-1723
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235875
      Issue No: Vol. 131, No. 14 (2018)
       
  • Effects of Dandelion Extract on the Proliferation of Rat Skeletal Muscle
           Cells and the Inhibition of a Lipopolysaccharide-Induced Inflammatory
           Reaction

    • Authors: Qiang Liu, Heng Zhao, Yue Gao, Yan Meng, Xiang-Xuan Zhao, Shi-Nong Pan
      Pages: 1724 - 1731
      Abstract: Qiang Liu, Heng Zhao, Yue Gao, Yan Meng, Xiang-Xuan Zhao, Shi-Nong Pan
      Chinese Medical Journal 2018 131(14):1724-1731
      Background: Dandelion is commonly used in traditional Chinese medicine with several active compounds found in extracts. It has a variety of pharmacological effects, such as a reduction in swelling and inflammation, and detoxification. The mechanism by which dandelion extract inhibits the inflammatory response in skeletal muscle cells remains unknown; therefore, the aim of this study was to investigate the effects of dandelion extract root on the proliferation of skeletal muscle cells and the alleviation of lipopolysaccharide (LPS)-induced inflammatory response in vitro.Methods: Rat skeletal muscle cells were isolated from Sprague-Dawley rat and cultured in vitro which were cultured in basal medium, or medium containing LPS or dandelion extract. Cell counting kit-8 (CCK-8) was employed to measure cell proliferation; meanwhile, the optimal concentration of dandelion extract and treatment time were selected. Crystal violet staining was used to detect the proliferation of muscle cells. Western blotting analysis was used to detect the levels of inflammatory factors, myogenic factor, and p-AKT protein expression.Results: The optimal concentration and treatment time of dandelion extract for the following study were 5 mg/ml and 4 days, respectively. Dandelion extract was found to increase proliferation of rat skeletal muscle cells (t = 3.145, P < 0.05), with the highest effect observed at 5 mg/ml. LPS was found to decrease proliferation of skeletal muscle cells (t = −131.959, P < 0.001), and dandelion extract could against this affection (t = 19.466, P < 0.01). LPS could induce expression of inflammatory factors, including interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α (IL-1β: t = 9.118, P < 0.01; IL-6: t = 4.346, P < 0.05; TNF-α: t = 15.806, P < 0.05), and dandelion extract was shown to reduce LPS-induced expression of IL-1β, IL-6 and TNF-α (IL-1β: t = −2.823, P < 0.05; IL-6: t = −3.348, P < 0.01; and TNF-α: t = −3.710, P < 0.01). Furthermore, LPS was also shown to decrease expression of myogenic factor, including myod1 and myogenin (MyoD1: t = 4.039, P < 0.05 and myogenin: t = 3.300, P < 0.01), but dandelion extract was shown to against this effect of LPS (MyoD1: t = −3.160, P < 0.05 and myogenin: t = −3.207, P < 0.01). And then, LPS was found to increase expression of p-AKT protein (p-AKT/AKT: t = 4.432, P < 0.05). Moreover, expression of p-AKT protein was found to decrease, with 5 mg/ml of dandelion extract (p-AKT/AKT: t = −3.618, P < 0.05).Conclusions: The findings indicate that dandelion extract plays an important role in skeletal muscle cells viability regulation, promote cells proliferation by increasing level of p-AKT protein expression, and reduce LPS-induced expression of inflammatory factors, inhibiting the inflammatory response of rat skeletal muscle cells.
      Citation: Chinese Medical Journal 2018 131(14):1724-1731
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235878
      Issue No: Vol. 131, No. 14 (2018)
       
  • Pulmonary Embolism in Patients with Acute Exacerbation of Chronic
           Obstructive Pulmonary Disease

    • Authors: Yao-Qian Cao, Li-Xia Dong, Jie Cao
      Pages: 1732 - 1737
      Abstract: Yao-Qian Cao, Li-Xia Dong, Jie Cao
      Chinese Medical Journal 2018 131(14):1732-1737
      Objective: In most countries, nearly 6% of the adults are suffering from chronic obstructive pulmonary disease (COPD), which puts a huge economic burden on the society. Moreover, COPD has been considered as an independent risk factor for pulmonary embolism (PE). In this review, we summarized the existing evidence that demonstrates the associations between COPD exacerbation and PE from various aspects, including epidemiology, pathophysiological changes, risk factors, clinical features, management, and prognosis.Data Sources: We searched the terms “chronic obstructive pulmonary disease,” “pulmonary embolism,” “exacerbations,” and “thromboembolic” in PubMed database and collected the results up to April 2018. The language was limited to English.Study Selection: We thoroughly examined the titles and abstracts of all studies that met our search strategy. The data from prospective studies, meta-analyses, retrospective studies, and recent reviews were selected for preparing this review.Results: The prevalence of PE in patients with COPD exacerbation varied a lot among different studies, mainly due to the variations in race, sample size, study design, research setting, and enrollment criteria. Overall, whites and African Americans showed significantly higher prevalence of PE than Asian people, and the hospitalized patients showed higher prevalence of PE compared to those who were evaluated in emergency department. PE is easily overlooked in patients with COPD exacerbation due to the similar clinical symptoms. However, several factors have been identified to contribute to the increased risk of PE during COPD exacerbation. Obesity and lower limb asymmetry were described as independent predictors for PE. Moreover, due to the high risk of PE, thromboprophylaxis has been used as an important treatment for hospitalized patients with COPD exacerbation.Conclusions: According to the previous studies, COPD patients with PE experienced an increased risk of death and prolonged length of hospital stay. Therefore, the thromboembolic risk in patients with acute exacerbation of COPD, especially in the hospitalized patients, should carefully be evaluated.
      Citation: Chinese Medical Journal 2018 131(14):1732-1737
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235865
      Issue No: Vol. 131, No. 14 (2018)
       
  • Ten Things to be Considered in Practicing Critical Care Echocardiography

    • Authors: Xin Ding, Da-Wei Liu, Yan-Gong Cao, Hong-Min Zhang, Huan Chen, Hua Zhao, Xiao-Ting Wang, Chinese Critical Ultrasound Study Group (CCUSG)
      Pages: 1738 - 1743
      Abstract: Xin Ding, Da-Wei Liu, Yan-Gong Cao, Hong-Min Zhang, Huan Chen, Hua Zhao, Xiao-Ting Wang, Chinese Critical Ultrasound Study Group (CCUSG)
      Chinese Medical Journal 2018 131(14):1738-1743

      Citation: Chinese Medical Journal 2018 131(14):1738-1743
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235868
      Issue No: Vol. 131, No. 14 (2018)
       
  • Unilateral Isolated Basal Vein Thrombosis Associated with Deep Cerebral
           Venous Infarction

    • Authors: Min-Jian Qiu, Jun Tian, Wei Luo, Bao-Rong Zhang
      Pages: 1744 - 1745
      Abstract: Min-Jian Qiu, Jun Tian, Wei Luo, Bao-Rong Zhang
      Chinese Medical Journal 2018 131(14):1744-1745

      Citation: Chinese Medical Journal 2018 131(14):1744-1745
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235876
      Issue No: Vol. 131, No. 14 (2018)
       
  • Successful Treatment of Erlotinib on Metastatic Adenoid Cystic Carcinoma
           of the Lacrimal Gland

    • Authors: Ke-Ke Nie, Jing Xu, Chen Gao, Zhong-Fa Zhang, Ke-Tao Lan, You-Xin Ji
      Pages: 1746 - 1747
      Abstract: Ke-Ke Nie, Jing Xu, Chen Gao, Zhong-Fa Zhang, Ke-Tao Lan, You-Xin Ji
      Chinese Medical Journal 2018 131(14):1746-1747

      Citation: Chinese Medical Journal 2018 131(14):1746-1747
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235887
      Issue No: Vol. 131, No. 14 (2018)
       
  • Reverse Postulation for “Disruption of Brain Networks”
           Hypothesis of Schizophrenia

    • Authors: Xin-Yu Guo, Shen Li, Hong-Jun Tian, Jie Li, Chuan-Jun Zhuo
      Pages: 1748 - 1749
      Abstract: Xin-Yu Guo, Shen Li, Hong-Jun Tian, Jie Li, Chuan-Jun Zhuo
      Chinese Medical Journal 2018 131(14):1748-1749

      Citation: Chinese Medical Journal 2018 131(14):1748-1749
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235871
      Issue No: Vol. 131, No. 14 (2018)
       
  • Effect of Education by Messaging Software on the Quality of Bowel
           Preparation for Colonoscopy

    • Authors: Qing-Xia Zhang, Jie Li, Qin Zhang, Yi Li, Cong-Han Lei, Bai-Xue Shang, Xiao-Shuang Guan, Qing Zhang
      Pages: 1750 - 1752
      Abstract: Qing-Xia Zhang, Jie Li, Qin Zhang, Yi Li, Cong-Han Lei, Bai-Xue Shang, Xiao-Shuang Guan, Qing Zhang
      Chinese Medical Journal 2018 131(14):1750-1752

      Citation: Chinese Medical Journal 2018 131(14):1750-1752
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235881
      Issue No: Vol. 131, No. 14 (2018)
       
  • Successful Management of a Rare Case of Humerus Non-Hodgkin&#39;s
           Lymphoma in Rapid Progress

    • Authors: Shu-Zhong Liu, Xi Zhou, An Song, Yi-Peng Wang, Yong Liu
      Pages: 1753 - 1754
      Abstract: Shu-Zhong Liu, Xi Zhou, An Song, Yi-Peng Wang, Yong Liu
      Chinese Medical Journal 2018 131(14):1753-1754

      Citation: Chinese Medical Journal 2018 131(14):1753-1754
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235886
      Issue No: Vol. 131, No. 14 (2018)
       
  • Acute Pancreatitis as a Long-term Complication of Pancreatectomy

    • Authors: Dong-Ya Huang, Qiang Li, Feng Guo, Kui-Rong Jiang, Cun-Cai Dai, Jun-Li Wu, Wen-Tao Gao, Yi Miao
      Pages: 1755 - 1756
      Abstract: Dong-Ya Huang, Qiang Li, Feng Guo, Kui-Rong Jiang, Cun-Cai Dai, Jun-Li Wu, Wen-Tao Gao, Yi Miao
      Chinese Medical Journal 2018 131(14):1755-1756

      Citation: Chinese Medical Journal 2018 131(14):1755-1756
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235882
      Issue No: Vol. 131, No. 14 (2018)
       
  • Hybrid Management for Supraceliac Aortic Aneurysm in a High-Risk Patient

    • Authors: Jun Seong Kwon, Jeong Kye Hwang, Sun Cheol Park, Sang Dong Kim
      Pages: 1757 - 1758
      Abstract: Jun Seong Kwon, Jeong Kye Hwang, Sun Cheol Park, Sang Dong Kim
      Chinese Medical Journal 2018 131(14):1757-1758

      Citation: Chinese Medical Journal 2018 131(14):1757-1758
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235885
      Issue No: Vol. 131, No. 14 (2018)
       
  • Influence of the Anatomy of the Collecting System Upon Percutaneous
           Nephrolithotomy for Removal of Renal Staghorn Stones

    • Authors: Bo Xiao, Xiao-Lin Diao, Wei-Guo Hu, Xin Zhang, Song Chen, Yu-Bao Liu, Yu-Zhe Tang, Wen-Jie Bai, Jian-Xing Li
      Pages: 1759 - 1760
      Abstract: Bo Xiao, Xiao-Lin Diao, Wei-Guo Hu, Xin Zhang, Song Chen, Yu-Bao Liu, Yu-Zhe Tang, Wen-Jie Bai, Jian-Xing Li
      Chinese Medical Journal 2018 131(14):1759-1760

      Citation: Chinese Medical Journal 2018 131(14):1759-1760
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235879
      Issue No: Vol. 131, No. 14 (2018)
       
  • Acquired Syphilis in a Chinese Family among Three Generations

    • Authors: Fu-Quan Long, Li-Shi Zhao, Jia Chen
      Pages: 1761 - 1762
      Abstract: Fu-Quan Long, Li-Shi Zhao, Jia Chen
      Chinese Medical Journal 2018 131(14):1761-1762

      Citation: Chinese Medical Journal 2018 131(14):1761-1762
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235888
      Issue No: Vol. 131, No. 14 (2018)
       
  • Diagnosis-Related Groups&#39; Payment Reform in Beijing

    • Authors: Wei-Ping Jiao
      Pages: 1763 - 1764
      Abstract: Wei-Ping Jiao
      Chinese Medical Journal 2018 131(14):1763-1764

      Citation: Chinese Medical Journal 2018 131(14):1763-1764
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235869
      Issue No: Vol. 131, No. 14 (2018)
       
  • Corrigendum: Genistein Improves Liver Damage in Male Mice Exposed to
           Morphine

    • Pages: 1764 - 1764
      Abstract:
      Chinese Medical Journal 2018 131(14):1764-1764

      Citation: Chinese Medical Journal 2018 131(14):1764-1764
      PubDate: Wed,4 Jul 2018
      DOI: 10.4103/0366-6999.235870
      Issue No: Vol. 131, No. 14 (2018)
       
 
 
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