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Publisher: Medknow Publishers   (Total: 429 journals)

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Showing 1 - 200 of 429 Journals sorted alphabetically
Acta Medica Intl.     Open Access   (SJR: 0.101, CiteScore: 0)
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advanced Biomedical Research     Open Access  
Advances in Human Biology     Open Access   (Followers: 3)
Advances in Skeletal Muscle Function Assessment     Open Access  
African J. for Infertility and Assisted Conception     Open Access  
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.25, CiteScore: 1)
African J. of Trauma     Open Access   (Followers: 1)
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Alexandria J. of Pediatrics     Open Access  
Ancient Science of Life     Open Access   (Followers: 5)
Anesthesia : Essays and Researches     Open Access   (Followers: 10)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.258, CiteScore: 1)
Annals of Bioanthropology     Open Access   (Followers: 4)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.308, CiteScore: 1)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery     Open Access  
Annals of Indian Psychiatry     Open Access  
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 9, SJR: 0.352, CiteScore: 1)
Annals of Saudi Medicine     Open Access   (SJR: 0.238, CiteScore: 1)
Annals of Thoracic Medicine     Open Access   (Followers: 6, SJR: 0.524, CiteScore: 1)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 13, SJR: 0.152, CiteScore: 0)
Annals of Tropical Pathology     Open Access  
Apollo Medicine     Open Access  
APOS Trends in Orthodontics     Open Access  
Arab J. of Interventional Radiology     Open Access  
Archives of Cardiovascular Imaging     Open Access   (Followers: 1, SJR: 0.187, CiteScore: 0)
Archives of Intl. Surgery     Open Access   (Followers: 10, SJR: 0.302, CiteScore: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Medicine and Surgery     Open Access  
Archives of Pharmacy Practice     Open Access   (Followers: 6, SJR: 0.102, CiteScore: 0)
Archives of Trauma Research     Open Access   (Followers: 3, SJR: 0.37, CiteScore: 2)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 4)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.856, CiteScore: 2)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.35, CiteScore: 1)
Asian Pacific J. of Reproduction     Open Access   (SJR: 0.227, CiteScore: 1)
Asian Pacific J. of Tropical Biomedicine     Open Access   (Followers: 2, SJR: 0.491, CiteScore: 2)
Asian Pacific J. of Tropical Medicine     Open Access   (Followers: 1, SJR: 0.561, CiteScore: 2)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
Biomedical and Biotechnology Research J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Canadian J. of Rural Medicine     Full-text available via subscription   (SJR: 0.202, CiteScore: 0)
Cancer Translational Medicine     Open Access   (Followers: 2)
Cardiology Plus     Open Access  
Chinese Medical J.     Open Access   (Followers: 10, SJR: 0.52, CiteScore: 1)
CHRISMED J. of Health and Research     Open Access   (Followers: 2)
Clinical Cancer Investigation J.     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 2)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 10, SJR: 0.811, CiteScore: 2)
Contemporary Clinical Dentistry     Open Access   (Followers: 4, SJR: 0.353, CiteScore: 1)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.543, CiteScore: 1)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.152, CiteScore: 0)
Dental Research J.     Open Access   (Followers: 11, SJR: 0.416, CiteScore: 1)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 6, SJR: 0.242, CiteScore: 0)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1, SJR: 1.799, CiteScore: 2)
Egyptian J. of Chest Diseases and Tuberculosis     Open Access   (Followers: 3, SJR: 0.155, CiteScore: 0)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.127, CiteScore: 0)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Nursing J.     Open Access  
Egyptian Orthopaedic J.     Open Access   (Followers: 2)
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.822, CiteScore: 2)
Environmental Disease     Open Access   (Followers: 3)
Eurasian J. of Pulmonology     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.749, CiteScore: 2)
European J. of General Dentistry     Open Access   (Followers: 1, SJR: 0.12, CiteScore: 0)
European J. of Prosthodontics     Open Access   (Followers: 3)
European J. of Psychology and Educational Studies     Open Access   (Followers: 11, SJR: 0.113, CiteScore: 0)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.112, CiteScore: 0)
Genome Integrity     Open Access   (Followers: 2, SJR: 0.153, CiteScore: 0)
Glioma     Open Access  
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Gynecology and Minimally Invasive Therapy     Open Access   (SJR: 0.311, CiteScore: 1)
Hamdan Medical J.     Open Access  
Heart and Mind     Open Access  
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
Ibnosina J. of Medicine and Biomedical Sciences     Open Access  
IJS Short Reports     Open Access  
Imam J. of Applied Sciences     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.478, CiteScore: 1)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (Followers: 1, SJR: 0.361, CiteScore: 1)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.37, CiteScore: 1)
Indian J. of Critical Care Medicine     Open Access   (Followers: 3, SJR: 0.604, CiteScore: 1)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.266, CiteScore: 1)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.468, CiteScore: 1)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 4, SJR: 0.445, CiteScore: 1)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1, SJR: 0.791, CiteScore: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4, SJR: 0.568, CiteScore: 1)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.425, CiteScore: 1)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.503, CiteScore: 1)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.656, CiteScore: 1)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.102, CiteScore: 0)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.347, CiteScore: 1)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.23, CiteScore: 0)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 3, SJR: 0.225, CiteScore: 1)
Indian J. of Ophthalmology     Open Access   (Followers: 4, SJR: 0.498, CiteScore: 1)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 8, SJR: 0.392, CiteScore: 1)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.199, CiteScore: 0)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.454, CiteScore: 1)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 2, SJR: 0.276, CiteScore: 1)
Indian J. of Pharmacology     Open Access   (SJR: 0.412, CiteScore: 1)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.311, CiteScore: 0)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.408, CiteScore: 1)
Indian J. of Psychological Medicine     Open Access   (SJR: 0.368, CiteScore: 1)
Indian J. of Public Health     Open Access   (Followers: 1)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Respiratory Care     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.119, CiteScore: 0)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.34, CiteScore: 0)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Transplantation     Open Access  
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Indian Spine J.     Open Access  
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intervention     Open Access   (Followers: 1)
Intl. Archives of Health Sciences     Open Access  
Intl. J. of Abdominal Wall and Hernia Surgery     Open Access   (Followers: 1)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Clinicopathological Correlation     Open Access  
Intl. J. of Community Dentistry     Open Access  
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1, SJR: 0.192, CiteScore: 0)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 3, SJR: 0.142, CiteScore: 0)
Intl. J. of Growth Factors and Stem Cells in Dentistry     Open Access  
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 6)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.535, CiteScore: 1)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4, SJR: 0.17, CiteScore: 0)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 2)
Intl. J. of Orofacial Biology     Open Access   (Followers: 1)
Intl. J. of Orofacial Research     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.623, CiteScore: 1)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 5, SJR: 0.653, CiteScore: 1)
Intl. J. of the Cardiovascular Academy     Open Access   (SJR: 0.105, CiteScore: 0)
Intl. J. of Trichology     Open Access   (SJR: 0.4, CiteScore: 1)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)

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Journal Cover
Chinese Medical Journal
Journal Prestige (SJR): 0.52
Citation Impact (citeScore): 1
Number of Followers: 10  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0366-6999 - ISSN (Online) 2542-5641
Published by Medknow Publishers Homepage  [429 journals]
  • Big Data Research in Chronic Kidney Disease

    • Authors: Xiao-Xi Zeng, Jing Liu, Liang Ma, Ping Fu
      Pages: 2647 - 2650
      Abstract: Xiao-Xi Zeng, Jing Liu, Liang Ma, Ping Fu
      Chinese Medical Journal 2018 131(22):2647-2650

      Citation: Chinese Medical Journal 2018 131(22):2647-2650
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245275
      Issue No: Vol. 131, No. 22 (2018)
       
  • Predictive Score Model for Delayed Graft Function Based on Hypothermic
           Machine Perfusion Variables in Kidney Transplantation

    • Authors: Chen-Guang Ding, Yang Li, Xiao-Hui Tian, Xiao-Jun Hu, Pu-Xu Tian, Xiao-Ming Ding, He-Li Xiang, Jin Zheng, Wu-Jun Xue
      Pages: 2651 - 2657
      Abstract: Chen-Guang Ding, Yang Li, Xiao-Hui Tian, Xiao-Jun Hu, Pu-Xu Tian, Xiao-Ming Ding, He-Li Xiang, Jin Zheng, Wu-Jun Xue
      Chinese Medical Journal 2018 131(22):2651-2657
      Background: Hypothermic machine perfusion (HMP) is being used more often in cardiac death kidney transplantation; however, the significance of assessing organ quality and predicting delayed graft function (DGF) by HMP parameters is still controversial. Therefore, we used a readily available HMP variable to design a scoring model that can identify the highest risk of DGF and provide the guidance and advice for organ allocation and DCD kidney assessment.Methods: From September 1, 2012 to August 31, 2016, 366 qualified kidneys were randomly assigned to the development and validation cohorts in a 2:1 distribution. The HMP variables of the development cohort served as candidate univariate predictors for DGF. The independent predictors of DGF were identified by multivariate logistic regression analysis with a P < 0.05. According to the odds ratios (ORs) value, each HMP variable was assigned a weighted integer, and the sum of the integers indicated the total risk score for each kidney. The validation cohort was used to verify the accuracy and reliability of the scoring model.Results: HMP duration (OR = 1.165, 95% confidence interval [CI]: 1.008–1.360, P = 0.043), resistance (OR = 2.190, 95% CI: 1.032–10.20, P < 0.001), and flow rate (OR = 0.931, 95% CI: 0.894–0.967, P = 0.011) were the independent predictors of identified DGF. The HMP predictive score ranged from 0 to 14, and there was a clear increase in the incidence of DGF, from the low predictive score group to the very high predictive score group. We formed four increasingly serious risk categories (scores 0–3, 4–7, 8–11, and 12–14) according to the frequency associated with the different risk scores of DGF. The HMP predictive score indicates good discriminative power with a c-statistic of 0.706 in the validation cohort, and it had significantly better prediction value for DGF compared to both terminal flow (P = 0.012) and resistance (P = 0.006).Conclusion: The HMP predictive score is a good noninvasive tool for assessing the quality of DCD kidneys, and it is potentially useful for physicians in making optimal decisions about the organs donated.
      Citation: Chinese Medical Journal 2018 131(22):2651-2657
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245278
      Issue No: Vol. 131, No. 22 (2018)
       
  • Renoprotection Provided by Dipeptidyl Peptidase-4 Inhibitors in
           Combination with Angiotensin Receptor Blockers in Patients with Type 2
           Diabetic Nephropathy

    • Authors: Dan-Dan Qiu, Jing Liu, Jing-Song Shi, Yu An, Yong-Chun Ge, Min-Lin Zhou, Song Jiang
      Pages: 2658 - 2665
      Abstract: Dan-Dan Qiu, Jing Liu, Jing-Song Shi, Yu An, Yong-Chun Ge, Min-Lin Zhou, Song Jiang
      Chinese Medical Journal 2018 131(22):2658-2665
      Background: Treatment with the dipeptidyl peptidase-4 inhibitors (DPP4i) and angiotensin receptor blockers (ARBs) in patients with type 2 diabetic nephropathy (DN) has not been well characterized. This study aimed to assess the renoprotection of this combined treatment in DN patients.Methods: A total of 159 type 2 DN patients from 2013 to 2015 were enrolled retrospectively from a prospective DN cohort at the National Clinical Research Center of Kidney Diseases, Jinling Hospital (China). Fifty-seven patients received DPP4i and ARB treatment, and 102 patients were treated with ARBs alone. All patients were followed up for at least 12 months. Statistical analyses were performed using Stata version 12.0.Results: There were no significant differences at baseline for age, sex, body mass index, duration of diabetes, fasting blood glucose (FBG), hemoglobin A1c (HbA1c), and estimated glomerular filtration rate (eGFR) between the two groups. Antihypertensive and antidiabetic medication use was similar in each group except calcium channel antagonists (P = 0.032). No significant changes in FBG and HbA1c were observed in the two groups after treatment. The eGFR decreased slower in the DPP4i + ARB group than in the ARB group at 12 months (Δ12 months: −2.48 ± 13.86 vs. −6.81 ± 12.52 ml·min–1·1.73m–2, P = 0.044). In addition, proteinuria was decreased further in the DPP4i + ARB group than in the ARB group after 24 months of treatment (Δ24 months: −0.18 [−1.00, 0.17] vs. 0.32 [−0.35, 0.88], P = 0.031). There were 36 patients with an eGFR decrease of more than 30% over 24 months. After adjusting for FBG, HbA1c, and other risk factors, DPP4i + ARB treatment was still associated with a reduced incidence of an eGFR decrease of 20% or 30%.Conclusions: The combined treatment of DPP4i and ARBs is superior to ARBs alone, as evidenced by the greater proteinuria reduction and lower eGFR decline. In addition, the renoprotection of DPP4i combined with ARBs was independent of glycemic control.
      Citation: Chinese Medical Journal 2018 131(22):2658-2665
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245277
      Issue No: Vol. 131, No. 22 (2018)
       
  • New Mutation of Coenzyme Q10 Monooxygenase 6 Causing Podocyte Injury in a
           Focal Segmental Glomerulosclerosis Patient

    • Authors: Cheng-Cheng Song, Quan Hong, Xiao-Dong Geng, Xu Wang, Shu-Qiang Wang, Shao-Yuan Cui, Man-Di Guo, Ou Li, Guang-Yan Cai, Xiang-Mei Chen, Di Wu
      Pages: 2666 - 2675
      Abstract: Cheng-Cheng Song, Quan Hong, Xiao-Dong Geng, Xu Wang, Shu-Qiang Wang, Shao-Yuan Cui, Man-Di Guo, Ou Li, Guang-Yan Cai, Xiang-Mei Chen, Di Wu
      Chinese Medical Journal 2018 131(22):2666-2675
      Background: Focal segmental glomerulosclerosis (FSGS) is a kidney disease that is commonly associated with proteinuria and the progressive loss of renal function, which is characterized by podocyte injury and the depletion and collapse of glomerular capillary segments. The pathogenesis of FSGS has not been completely elucidated; however, recent advances in molecular genetics have provided increasing evidence that podocyte structural and functional disruption is central to FSGS pathogenesis. Here, we identified a patient with FSGS and aimed to characterize the pathogenic gene and verify its mechanism.Methods: Using next-generation sequencing and Sanger sequencing, we screened the causative gene that was linked to FSGS in this study. The patient's total blood RNA was extracted to validate the messenger RNA (mRNA) expression of coenzyme Q10 monooxygenase 6 (COQ6) and validated it by immunohistochemistry. COQ6 knockdown in podocytes was performed in vitro with small interfering RNA, and then, F-actin was determined using immunofluorescence staining. Cell apoptosis was evaluated by flow cytometry, the expression of active caspase-3 was determined by Western blot, and mitochondrial function was detected by MitoSOX.Results: Using whole-exome sequencing and Sanger sequencing, we screened a new causative gene, COQ6, NM_182480: exon1: c.G41A: p.W14X. The mRNA expression of COQ6 in the proband showed decreased. Moreover, the expression of COQ6, which was validated by immunohistochemistry, also had the same change in the proband. Finally, we focused on the COQ6 gene to clarify the mechanism of podocyte injury. Flow cytometry showed significantly increased in apoptotic podocytes, and Western blotting showed increases in active caspase-3 in si-COQ6 podocytes. Meanwhile, reactive oxygen species (ROS) levels were increased and F-actin immunofluorescence was irregularly distributed in the si-COQ6 group.Conclusions: This study reported a possible mechanism for FSGS and suggested that a new mutation in COQ6, which could cause respiratory chain defect, increase the generation of ROS, destroy the podocyte cytoskeleton, and induce apoptosis. It provides basic theoretical basis for the screening of FSGS in the future.
      Citation: Chinese Medical Journal 2018 131(22):2666-2675
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245158
      Issue No: Vol. 131, No. 22 (2018)
       
  • Beneficial Effect of Moderately Increasing Hypothermic Machine Perfusion
           Pressure on Donor after Cardiac Death Renal Transplantation

    • Authors: Chen-Guang Ding, Pu-Xun Tian, Xiao-Ming Ding, He-Li Xiang, Yang Li, Xiao-Hui Tian, Feng Han, Qian-Hui Tai, Qian-Long Liu, Jin Zheng, Wu-Jun Xue
      Pages: 2676 - 2682
      Abstract: Chen-Guang Ding, Pu-Xun Tian, Xiao-Ming Ding, He-Li Xiang, Yang Li, Xiao-Hui Tian, Feng Han, Qian-Hui Tai, Qian-Long Liu, Jin Zheng, Wu-Jun Xue
      Chinese Medical Journal 2018 131(22):2676-2682
      Background: Vascular resistance and flow rate during hypothermic machine perfusion (HMP) of kidneys is correlated with graft function. We aimed to determine the effects of increasing HMP pressure versus maintaining the initial pressure on kidney transplantation outcomes.Methods: We retrospectively reviewed the data of 76 primary transplantation patients who received HMP-preserved kidneys from 48 donors after cardiac death between September 1, 2013, and August 31, 2015. HMP pressure was increased from 30 to 40 mmHg (1 mmHg = 0.133 kPa) in kidneys with poor flow and/or vascular resistance (increased pressure [IP] group; 36 patients); otherwise, the initial pressure was maintained (constant pressure group; 40 patients). Finally, the clinical characteristics and transplantation outcomes in both groups were assessed.Results: Delayed graft function (DGF) incidence, 1-year allograft, patient survival, kidney function recovery time, and serum creatinine level on day 30 were similar in both groups, with improved flow and resistance in the IP group. Among patients with DGF, kidney function recovery time and DGF duration were ameliorated in the IP group. Multivariate logistic regression analysis revealed that donor hypertension (odds ratio [OR]: 1.43, 95% confidence interval [CI]: 1.02–2.06, P = 0.035), donor terminal serum creatinine (OR: 1.27, 95% CI: 1.06–1.62, P = 0.023), warm ischemic time (OR: 3.45, 95% CI: 1.97–6.37, P = 0.002), and terminal resistance (OR: 3.12, 95% CI: 1.76–6.09, P = 0.012) were independent predictors of DGF. Cox proportional hazards analysis showed that terminal resistance (hazard ratio: 2.06, 95% CI: 1.32–5.16, P = 0.032) significantly affected graft survival.Conclusion: Increased HMP pressure improves graft perfusion but does not affect DGF incidence or 1-year graft survival.
      Citation: Chinese Medical Journal 2018 131(22):2676-2682
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245274
      Issue No: Vol. 131, No. 22 (2018)
       
  • Efficacy and Safety of Tofacitinib in Chinese Patients with Rheumatoid
           Arthritis

    • Authors: Zhan-Guo Li, Yi Liu, Hu-Ji Xu, Zhi-Wei Chen, Chun-De Bao, Jie-Ruo Gu, Dong-Bao Zhao, Yuan An, Lie-Ju Hwang, Lisy Wang, Joel Kremer, Qi-Zhe Wu
      Pages: 2683 - 2692
      Abstract: Zhan-Guo Li, Yi Liu, Hu-Ji Xu, Zhi-Wei Chen, Chun-De Bao, Jie-Ruo Gu, Dong-Bao Zhao, Yuan An, Lie-Ju Hwang, Lisy Wang, Joel Kremer, Qi-Zhe Wu
      Chinese Medical Journal 2018 131(22):2683-2692
      Background: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). This study assessed the efficacy and safety of tofacitinib in Chinese patients with RA enrolled in Phase 3 and long-term extension (LTE) studies.Methods: ORAL Sync was a 1-year, randomized, placebo-controlled, Phase 3 trial. Patients received tofacitinib 5 or 10 mg twice daily (BID) or placebo advanced to tofacitinib 5 or 10 mg BID at 3 or 6 months. All patients remained on ≥1 background conventional synthetic disease-modifying antirheumatic drug. ORAL Sequel is an open-label LTE study (data-cut: March 2015; data collection and analyses were ongoing, and study database was not locked at the time of analysis; study was closed in 2017). Efficacy outcomes: American College of Rheumatology (ACR) 20/50/70 response rates and Disease Activity Score in 28 joints using erythrocyte sedimentation rate (DAS28-4 [ESR]). Patient- and physician-reported outcomes: Health Assessment Questionnaire-Disability Index (HAQ-DI), Patient and Physician Global Assessment of Arthritis, and pain (visual analog scale). Safety was assessed throughout.Results: ORAL Sync included 218 patients; 192 were subsequently enrolled into ORAL Sequel. In ORAL Sync, more patients achieved ACR20 (tofacitinib 5 mg BID, 67.4%; 10 mg BID, 70.6%; placebo, 34.1%) and DAS28-4 (ESR) <2.6 (tofacitinib 5 mg BID, 7.1%; 10 mg BID, 13.1%; placebo, 2.3%) with tofacitinib versus placebo at Month 6. Mean changes from baseline in HAQ-DI were greater with tofacitinib versus placebo at Month 6. In ORAL Sequel, efficacy was consistent to Month 48. Incidence rates for adverse events of special interest in tofacitinib-treated patients were similar to the global population.Conclusions: Tofacitinib significantly reduced signs/symptoms and improved physical function and quality of life in Chinese patients with moderate-to-severely active RA up to Month 48. The safety profile was consistent with the global population.Clinical Trial Identifier: NCT00856544 and NCT00413699.
      Citation: Chinese Medical Journal 2018 131(22):2683-2692
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245157
      Issue No: Vol. 131, No. 22 (2018)
       
  • Impact of CYP3A4*1G Polymorphism on Fentanyl Analgesia Assessed by
           Analgesia Nociception Index in Chinese Patients Undergoing Hysteroscopy

    • Authors: Qi Yan, Yi Su, Lan Gao, Nan Ding, Hong-Ying Zhang, Wen E&#8201;, Yue Wang, Yi Feng, Hai-Yan An
      Pages: 2693 - 2698
      Abstract: Qi Yan, Yi Su, Lan Gao, Nan Ding, Hong-Ying Zhang, Wen E , Yue Wang, Yi Feng, Hai-Yan An
      Chinese Medical Journal 2018 131(22):2693-2698
      Background: The clinical efficacy of fentanyl for pain control differs greatly across individuals. The purpose of this study was to investigate the impact of CYP3A4*1G polymorphism including wild-type homozygote (CYP3A4*1/*1, GG), mutant heterozygote (CYP3A4*1/*1G, GA), and mutant homozygote (CYP3A4*1G/*1G, AA) on fentanyl analgesia in Chinese patients undergoing hysteroscopy by the assessment of analgesia nociception index (ANI).Methods: A total of 200 gynecologic patients scheduled for elective hysteroscopy under general anesthesia at Peking University People's Hospital from May to December in 2017 were enrolled in this study. Venous blood was withdrawn for genotyping of CYP3A4*1G before operation. Fentanyl 1 μg/kg was administered preoperatively followed by target-controlled infusion of propofol for induction and maintenance. Intraoperative analgesic efficacy of fentanyl was assessed by ANI monitoring at T0 (entering room), T1 (cervical dilation), T2 (start of cervical aspiration), and T3 (end of cervical aspiration) time points. The duration of propofol infusion and total dosage of propofol were recorded as well.Results: The patients were divided into three groups according to CYP3A4*1G polymorphism, including 143 in GG group, 47 in GA group, and 10 in AA group. There was no significant difference in clinical demographics among three groups. The frequency of CYP3A4*1G variant alleles accounted for 16.8% and the distribution of variant alleles was consistent with Hardy–Weinberg equilibrium. Using a multilevel model, ANI values at T1 (63.81 ± 19.61), T2 (63.63 ± 17.82), and T3 (65.68 ± 17.79) were significantly lower than that at T0 (77.16 ± 12.93) in the study population (F = 23.50, P < 0.001), suggesting that higher levels of pain at T1, T2, and T3 than T0. Patients with GG genotype showed significantly lower ANI than those with GA or AA genotypes during hysteroscopy under the same dose of fentanyl.Conclusion: CYP3A4*1G polymorphism associated with the analgesic efficacy of intraoperative fentanyl in the patients undergoing hysteroscopy under general anesthesia.
      Citation: Chinese Medical Journal 2018 131(22):2693-2698
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.243934
      Issue No: Vol. 131, No. 22 (2018)
       
  • Validation of Predictive Value of Patterns of Nonadherence to Antiplatelet
           Regimen in Stented Patients Thrombotic Risk Score in Chinese Population
           Undergoing Percutaneous Coronary Intervention: A Prospective Observational
           Study

    • Authors: Xue-Yan Zhao, Jian-Xin Li, Xiao-Fang Tang, Jing-Jing Xu, Ying Song, Lin Jiang, Jue Chen, Lei Song, Li-Jian Gao, Zhan Gao, Shu-Bin Qiao, Yue-Jin Yang, Run-Lin Gao, Bo Xu, Jin-Qing Yuan
      Pages: 2699 - 2704
      Abstract: Xue-Yan Zhao, Jian-Xin Li, Xiao-Fang Tang, Jing-Jing Xu, Ying Song, Lin Jiang, Jue Chen, Lei Song, Li-Jian Gao, Zhan Gao, Shu-Bin Qiao, Yue-Jin Yang, Run-Lin Gao, Bo Xu, Jin-Qing Yuan
      Chinese Medical Journal 2018 131(22):2699-2704
      Background: The patterns of nonadherence to antiplatelet regimen in stented patients (PARIS) thrombotic risk score are a novel score for predicting the risk of coronary thrombotic events (CTEs) after percutaneous coronary intervention (PCI) with drug-eluting stents. However, the prognostic value of this score has not been fully evaluated in non-Euro-American PCI populations.Methods: We performed a prospective, observational study of 10,724 patients who underwent PCI in Fuwai hospital, China and evaluated the PARIS thrombotic risk score's predictive value of CTEs in the PCI population. The area under the receiver operating characteristic curve (AUROC) was used to assess the predictive value of the PARIS score for CTE.Results: Among 9782 patients without in-hospital events, a total of 95 CTEs occurred during the 2-year follow-up. The PARIS score was significantly higher in patients with CTEs (3.38 ± 2.04) compared with patients without events (2.53 ± 1.70, P < 0.001). According to the risk stratification of the PARIS thrombotic score, the risk of CTEs in the high-risk group was 3.14 times higher than that in the low-risk group (hazard ratio [HR], 3.14; 95% confidence interval [CI], 1.92–5.13; P < 0.001). However, the risk of CTEs in the intermediate-risk and low-risk groups was not significant (HR, 1.39; 95% CI, [0.86–2.24]; P = 0.184). The PARIS score showed prognostic value in evaluating CTEs in the overall population (AUROC, 0.621; 95% CI, 0.561–0.681), the acute coronary syndrome (ACS) population (AUROC, 0.617; 95% CI, 0.534–0.700; P = 0.003), and the non-ACS population (AUROC, 0.647; 95% CI, 0.558–0.736; P = 0.001).Conclusions: In a real-world Chinese population, the PARIS thrombotic risk score shows a modest prognostic value for CTEs in patients after PCI. This score also has a predictive value for CTEs in the ACS and non-ACS subgroup populations.
      Citation: Chinese Medical Journal 2018 131(22):2699-2704
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245263
      Issue No: Vol. 131, No. 22 (2018)
       
  • Clinical, Neuroimaging, and Pathological Analyses of 13 Chinese Leigh
           Syndrome Patients with Mitochondrial DNA Mutations

    • Authors: Xiao-Lin Yu, Chuan-Zhu Yan, Kun-Qian Ji, Peng-Fei Lin, Xue-Bi Xu, Ting-Jun Dai, Wei Li, Yu-Ying Zhao
      Pages: 2705 - 2712
      Abstract: Xiao-Lin Yu, Chuan-Zhu Yan, Kun-Qian Ji, Peng-Fei Lin, Xue-Bi Xu, Ting-Jun Dai, Wei Li, Yu-Ying Zhao
      Chinese Medical Journal 2018 131(22):2705-2712
      Background: Leigh syndrome (LS) is a rare disease caused by mitochondrial defects and has high phenotypic and genotypic heterogeneity. We analyzed the clinical symptoms, neuroimaging, muscular histopathology, and genotypes of 13 Chinese LS patients with mitochondrial DNA (mtDNA) mutations.Methods: Mutations in mtDNA were identified by targeted sequencing. The brain imaging features on magnetic resonance imaging (MRI) were analyzed. The levels of lactate in fasting blood and cerebrospinal fluid (CSF) were routinely tested. The levels of urinary organic acids, plasma amino acids, and acylcarnitines were examined with gas chromatography–mass spectrometry and tandem mass spectrometry. The histopathological traits of skeletal muscles were analyzed under microscope.Results: Among 13 patients, mutations of MT-NDs (n = 8) and MT-ATP6 (n = 4) genes were most common. Strabismus (8/13), muscle weakness (8/13), and ataxia (5/13) were also common, especially for the patients with late-onset age after 2 years old. However, respiratory distress was common in patients with early-onset age before 2 years old. The most frequently affected brain area in these patients was the brain stem (12/13), particularly the dorsal part of midbrain, followed by basal ganglia (6/13), thalamus (6/13), cerebellum (5/13), and supratentorial white matter (2/13). Besides, the elevated lactate levels in CSF (6/6) were more common than those in serum (7/13). However, the analysis of abnormal plasma amino acid and urinary organic acid showed limited results (0/3 and 1/4, respectively). Muscular histopathology showed mitochondrial myopathy in the three late-onset patients but not in the early-onset ones.Conclusions: Noninvasive genetic screening is recommended for mtDNA mutations in MT-NDs and MT-ATP6 genes in patients with ophthalmoplegia, muscle weakness, ataxia, and respiratory disorder. Furthermore, the lactate detection in CSF and the brain MRI scanning are suggested as the diagnosis methods for LS patients with mtDNA mutations.
      Citation: Chinese Medical Journal 2018 131(22):2705-2712
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245265
      Issue No: Vol. 131, No. 22 (2018)
       
  • Purinergic 2X7 Receptor is Involved in the Podocyte Damage of
           Obesity-Related Glomerulopathy via Activating Nucleotide-Binding and
           Oligomerization Domain-Like Receptor Protein 3 Inflammasome

    • Authors: Xiao-Xia Hou, Hong-Rui Dong, Li-Jun Sun, Min Yang, Hong Cheng, Yi-Pu Chen
      Pages: 2713 - 2725
      Abstract: Xiao-Xia Hou, Hong-Rui Dong, Li-Jun Sun, Min Yang, Hong Cheng, Yi-Pu Chen
      Chinese Medical Journal 2018 131(22):2713-2725
      Background: The nucleotide-binding and oligomerization domain-like receptor protein 3 (NLRP3) inflammasome composed of NLRP3, apoptosis-associated speck-like protein containing CARD (ASC), and caspase-1 is engaged in the inflammatory response of many kidney diseases and can be activated by purinergic 2X7 receptor (P2X7R). This study was conducted to explore whether P2X7R plays a pathogenic role in the podocyte damage of obesity-related glomerulopathy (ORG) and whether this role is mediated by the activation of NLRP3 inflammasome.Methods: A mouse model of ORG was established by high-fat diet feeding. The conditionally immortalized mouse podocytes were cultured with leptin or with leptin and P2X7R antagonist (KN-62 or A438079). The mRNA and protein expression of the P2X7R and NLRP3 inflammasome components including NLRP3, ASC, and caspase-1, as well as the podocyte-associated molecules including nephrin, podocin, and desmin in mouse renal cortex or cultured mouse podocytes were tested by real-time-polymerase chain reaction and Western blot analysis, respectively.Results: The significantly upregulated expression of P2X7R and NLRP3 inflammasome components and the NLRP3 inflammasome activation were observed in the renal cortex (in fact their location in podocytes was proved by confocal microscopy) of ORG mice in vivo, which were accompanied with the morphological changes of podocyte damage and the expression changes of podocyte-associated molecules. Similar changes in the expression of P2X7R and NLRP3 inflammasome components as well as in the expression of podocyte-associated molecules were also observed in the cultured podocyte studies treated by leptin in vitro, and all of the above changes were significantly attenuated by the P2X7R antagonist KN-62 or A438079.Conclusions: P2X7R could trigger the activation of NLRP3 inflammasome, and the activated P2X7R/NLRP3 inflammasome in podocytes might be involved in the podocyte damage of ORG.
      Citation: Chinese Medical Journal 2018 131(22):2713-2725
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245270
      Issue No: Vol. 131, No. 22 (2018)
       
  • Effect of Endothelial Microparticles Induced by Hypoxia on Migration and
           Angiogenesis of Human Umbilical Vein Endothelial Cells by Delivering
           MicroRNA-19b

    • Authors: Hui-Zhu Liang, Su-Fang Li, Feng Zhang, Man-Yan Wu, Chang-Long Li, Jun-Xian Song, Chongyou Lee, Hong Chen
      Pages: 2726 - 2733
      Abstract: Hui-Zhu Liang, Su-Fang Li, Feng Zhang, Man-Yan Wu, Chang-Long Li, Jun-Xian Song, Chongyou Lee, Hong Chen
      Chinese Medical Journal 2018 131(22):2726-2733
      Background: Microparticles (MPs) are small extracellular plasma membrane particles shed by activated and apoptotic cells, which are involved in the development of atherosclerosis. Our previous study found that microRNA (miR)-19b encapsulated within endothelial MPs (EMPs) may contribute to the upregulation of circulating miR-19b in unstable angina patients. Hypoxia is involved in atherosclerosis as a critical pathological stimulus. However, it still remains unclear whether the increase of miR-19b levels in EMPs is related to hypoxia and if the effect of miR-19b – wrapped within EMPs – stimulates hypoxia on vascular endothelial cells. This study aimed to explore the changes of miR-19b in EMPs induced by hypoxia as well as their effects on endothelial cells.Methods: Human umbilical vein endothelial cells (HUVECs) were cultured in vitro and arranged to harvest EMPs in two parts: the first part consisted of EMPcontrol and EMPhypoxia and the second part included EMPvehicle, EMPNC mimic, and EMPmiR-19b mimic. Cell migration was detected by scratch migration and transwell chamber migration. Angiogenesis was assessed by tube formation assays. Furthermore, we predicted the target gene of miR-19b by bioinformatics analysis, and luciferase assay was used to verify the targeted gene of miR-19b. Data were analyzed by one-way analysis of variance. Student's t-test was used when two groups were compared.Results: Compared with EMPcontrol- and EMPhypoxia-inhibited migration of cells by scratch migration assay (80.77 ± 1.10 vs. 28.37 ± 1.40, P < 0. 001) and transwell chamber migration assay (83.00 ± 3.46 vs. 235.00 ± 16.52, P < 0.01), the number of tube formations was markedly reduced by 70% in the EMPhypoxia group (P < 0.001) in vitro analysis of HUVECs. Meanwhile, a strong inhibition of migration and tube formation of HUVECs in the presence of miR-19b-enriched EMPmiR-19b mimic was observed. This effect might be due to the delivery of miR-19b in EMPs. Transforming growth factor-β2 (TGFβ2) was predicted to be one of the target genes of miR-19b, and we further confirmed that TGFβ2 was a direct target gene of miR-19b using the luciferase assay. The expression of TGFβ2 in HUVECs was inhibited by treatment with EMPhypoxia and EMPmiR-19b mimic.Conclusions: MiR-19b in EMPs induced by hypoxia could reduce endothelial cell migration and angiogenesis by downregulating TGFβ2 expression, which may have inhibited the progression of atherosclerosis.
      Citation: Chinese Medical Journal 2018 131(22):2726-2733
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245271
      Issue No: Vol. 131, No. 22 (2018)
       
  • Helicobacter pylori Infection is Associated with Occurrence of Proteinuria
           in Type 2 Diabetes Patients: A Systemic Review and Meta-Analysis

    • Authors: Yan Shi, Jia-Yu Duan, Dong-Wei Liu, Ying-Jin Qiao, Qiu-Xia Han, Shao-Kang Pan, Li Tang, Guang-Yan Cai, Xiang-Mei Chen, Zhang-Suo Liu, Han-Yu Zhu
      Pages: 2734 - 2740
      Abstract: Yan Shi, Jia-Yu Duan, Dong-Wei Liu, Ying-Jin Qiao, Qiu-Xia Han, Shao-Kang Pan, Li Tang, Guang-Yan Cai, Xiang-Mei Chen, Zhang-Suo Liu, Han-Yu Zhu
      Chinese Medical Journal 2018 131(22):2734-2740
      Background: Type 2 diabetes (T2DM) patients are susceptible to Helicobacter pylori (HP), and it has been reported that the occurrence of proteinuria is associated with HP infection in T2DM patients; however, this view remains controversial. This meta-analysis aimed to explore the association between HP infection and the occurrence of proteinuria in T2DM patients. In addition, we hope to provide some recommendations to readers in clinical or related fields.Methods: Our meta-analysis was conducted with the methodology of the Cochrane Collaboration. Search strategies were formulated by relevant professionals. Case–control studies that compared the occurrence of proteinuria in T2DM patients with and without HP infection were involved in our meta-analysis. Relevant English or Chinese studies were searched on online databases before 2018, including PubMed, the Cochrane library, Medline, Google Scholar, the China National Infrastructure, and Wanfang database. The search strategies were “diabetic proteinuria, diabetic microalbuminuria, diabetic albuminuria, diabetic kidney disease, diabetic renal dysfunction, diabetic renal disease, diabetic nephropathy, diabetic complications, and diabetic mellitus, combined with HP.” The quality of these involved articles was separately assessed by two investigators using the Newcastle–Ottawa Scale (NOS). Odds ratios (ORs) and associated 95% confidence intervals (CIs) were extracted and pooled using fixed-effects models.Results: Seven studies involving 1029 participants were included. The quality of these seven articles was all above five stars as assessed by NOS, and there was no significant publication bias in our meta-analysis. We found that T2DM patients with HP infection had a 2.00 times higher risk of the occurrence of proteinuria than patients without HP infection (OR: 2.00, 95% CI: 1.48–2.69).Conclusions: Our analysis showed that HP infection was associated with the occurrence of proteinuria in T2DM patients. HP radical surgery might be a therapeutic option for protecting kidney function in patients with T2DM.
      Citation: Chinese Medical Journal 2018 131(22):2734-2740
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245269
      Issue No: Vol. 131, No. 22 (2018)
       
  • Statistical Prediction in Pathological Types of Chronic Kidney Disease

    • Authors: Mei-Fang Song, Zong-Wei Yi, Xue-Jing Zhu, Xue-Ling Qu, Chang Wang, Zai-Qi Zhang, Lin Sun, Fu-You Liu, Yuan Yang
      Pages: 2741 - 2742
      Abstract: Mei-Fang Song, Zong-Wei Yi, Xue-Jing Zhu, Xue-Ling Qu, Chang Wang, Zai-Qi Zhang, Lin Sun, Fu-You Liu, Yuan Yang
      Chinese Medical Journal 2018 131(22):2741-2742

      Citation: Chinese Medical Journal 2018 131(22):2741-2742
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245273
      Issue No: Vol. 131, No. 22 (2018)
       
  • Serum Metabolic Profiling in a Mouse Model of Adriamycin-Induced Focal
           Segmental Glomerulosclerosis

    • Authors: Li Lyu, Cai-Li Wang, Zeng-Yan Li, Ying-Jin Shi, Yan-Hui Zhang, Yan Mi, Zhao Hu
      Pages: 2743 - 2746
      Abstract: Li Lyu, Cai-Li Wang, Zeng-Yan Li, Ying-Jin Shi, Yan-Hui Zhang, Yan Mi, Zhao Hu
      Chinese Medical Journal 2018 131(22):2743-2746

      Citation: Chinese Medical Journal 2018 131(22):2743-2746
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245266
      Issue No: Vol. 131, No. 22 (2018)
       
  • A Case of Podocytic Infolding Glomerulopathy with Primary
           Sjögren's Syndrome and Hashimoto's Thyroiditis

    • Authors: Jun-Yan Fang, A-Hui Song, Bo Shen, Ying-Li Liu
      Pages: 2747 - 2748
      Abstract: Jun-Yan Fang, A-Hui Song, Bo Shen, Ying-Li Liu
      Chinese Medical Journal 2018 131(22):2747-2748

      Citation: Chinese Medical Journal 2018 131(22):2747-2748
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245276
      Issue No: Vol. 131, No. 22 (2018)
       
  • Prevalence of Chronic Kidney Disease-Mineral Bone Disorder in Hemodialysis
           Patients in Hebei, China

    • Authors: Jing-Jing Jin, Sheng-Lei Zhang, Jin-Sheng Xu, Li-Wen Cui, Hui-Ran Zhang, Ya-Ling Bai
      Pages: 2749 - 2751
      Abstract: Jing-Jing Jin, Sheng-Lei Zhang, Jin-Sheng Xu, Li-Wen Cui, Hui-Ran Zhang, Ya-Ling Bai
      Chinese Medical Journal 2018 131(22):2749-2751

      Citation: Chinese Medical Journal 2018 131(22):2749-2751
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245264
      Issue No: Vol. 131, No. 22 (2018)
       
  • Small Interfering RNA Targeting α-Fodrin Suppressing the Immune
           Response of Sjögren's Syndrome Mice

    • Authors: Xiao-Lin Sun, Chun-Yan Pang, Yuan Liu, Wei Zhang, Yong-Fu Wang
      Pages: 2752 - 2754
      Abstract: Xiao-Lin Sun, Chun-Yan Pang, Yuan Liu, Wei Zhang, Yong-Fu Wang
      Chinese Medical Journal 2018 131(22):2752-2754

      Citation: Chinese Medical Journal 2018 131(22):2752-2754
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.238761
      Issue No: Vol. 131, No. 22 (2018)
       
  • Mining and Correlation Analysis of Association Rules between Properties
           and Therapeutic Efficacy of Chinese Materia Medica Based on Strategy
           Pattern

    • Authors: Di-Yao Wu, Xin-You Zhang, Xiao-Ling Zhou
      Pages: 2755 - 2757
      Abstract: Di-Yao Wu, Xin-You Zhang, Xiao-Ling Zhou
      Chinese Medical Journal 2018 131(22):2755-2757

      Citation: Chinese Medical Journal 2018 131(22):2755-2757
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245262
      Issue No: Vol. 131, No. 22 (2018)
       
  • A Rare Cause of Recurrent Fatal Hemoptysis: Dieulafoy&#39;s Disease
           of the Bronchus

    • Authors: Feng Wang, Tu-Guang Kuang, Jian-Feng Wang, Yuan-Hua Yang
      Pages: 2758 - 2759
      Abstract: Feng Wang, Tu-Guang Kuang, Jian-Feng Wang, Yuan-Hua Yang
      Chinese Medical Journal 2018 131(22):2758-2759

      Citation: Chinese Medical Journal 2018 131(22):2758-2759
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245279
      Issue No: Vol. 131, No. 22 (2018)
       
  • Cardiac Resynchronization Therapy-Pacemaker Implantation Guided by
           Three-Dimensional Electroanatomic Mapping for a Chinese Young Man with
           Danon Disease

    • Authors: Lan-Yan Guo, Bo Wang, Min Shen, Bing Liu, Li-Wen Liu
      Pages: 2760 - 2762
      Abstract: Lan-Yan Guo, Bo Wang, Min Shen, Bing Liu, Li-Wen Liu
      Chinese Medical Journal 2018 131(22):2760-2762

      Citation: Chinese Medical Journal 2018 131(22):2760-2762
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245156
      Issue No: Vol. 131, No. 22 (2018)
       
  • Evaluation of the Spasticity after Botulinum Toxin Injection Using
           Paired-Pulse Transcranial Magnetic Stimulation

    • Authors: Chin-Hsuan Chia, Fang Li, Qin-Ying Li, Wen-Ting Qin
      Pages: 2763 - 2764
      Abstract: Chin-Hsuan Chia, Fang Li, Qin-Ying Li, Wen-Ting Qin
      Chinese Medical Journal 2018 131(22):2763-2764

      Citation: Chinese Medical Journal 2018 131(22):2763-2764
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245267
      Issue No: Vol. 131, No. 22 (2018)
       
  • Severe Lymphopenia and Related T-cell Immunity in an Avian Influenza A
           (H7N9)-Infected Patient

    • Authors: Nan-Nan Zhang, Yi Zhang, Jin-Gen Xia, Min Li, Xu Huang, Ruo-Yang Zhang, Qing-Yuan Zhan
      Pages: 2765 - 2766
      Abstract: Nan-Nan Zhang, Yi Zhang, Jin-Gen Xia, Min Li, Xu Huang, Ruo-Yang Zhang, Qing-Yuan Zhan
      Chinese Medical Journal 2018 131(22):2765-2766

      Citation: Chinese Medical Journal 2018 131(22):2765-2766
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245268
      Issue No: Vol. 131, No. 22 (2018)
       
  • Stenting for Aorto-Ostial In-Stent Restenosis via Side Strut of an
           Excessively Protruding Stent Guided by Intracoronary Imaging

    • Authors: Yu Du, Ying-Xin Zhao, Wei Liu, Jian-Wei Zhang, Zhen-Xian Yan, Yu-Jie Zhou
      Pages: 2767 - 2768
      Abstract: Yu Du, Ying-Xin Zhao, Wei Liu, Jian-Wei Zhang, Zhen-Xian Yan, Yu-Jie Zhou
      Chinese Medical Journal 2018 131(22):2767-2768

      Citation: Chinese Medical Journal 2018 131(22):2767-2768
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245261
      Issue No: Vol. 131, No. 22 (2018)
       
  • Renal Fibrosis and Mitochondrial Damage

    • Authors: Jiao Qin, Zhang-Zhe Peng, Qian Li, Rui Wen, Li-Jian Tao
      Pages: 2769 - 2772
      Abstract: Jiao Qin, Zhang-Zhe Peng, Qian Li, Rui Wen, Li-Jian Tao
      Chinese Medical Journal 2018 131(22):2769-2772

      Citation: Chinese Medical Journal 2018 131(22):2769-2772
      PubDate: Tue,13 Nov 2018
      DOI: 10.4103/0366-6999.245272
      Issue No: Vol. 131, No. 22 (2018)
       
 
 
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