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Publisher: Medknow Publishers   (Total: 429 journals)

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Showing 1 - 200 of 429 Journals sorted alphabetically
Acta Medica Intl.     Open Access   (SJR: 0.101, CiteScore: 0)
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advanced Biomedical Research     Open Access  
Advances in Human Biology     Open Access   (Followers: 3)
Advances in Skeletal Muscle Function Assessment     Open Access  
African J. for Infertility and Assisted Conception     Open Access  
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.25, CiteScore: 1)
African J. of Trauma     Open Access   (Followers: 1)
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Alexandria J. of Pediatrics     Open Access  
Ancient Science of Life     Open Access   (Followers: 5)
Anesthesia : Essays and Researches     Open Access   (Followers: 10)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.258, CiteScore: 1)
Annals of Bioanthropology     Open Access   (Followers: 4)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.308, CiteScore: 1)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery     Open Access  
Annals of Indian Psychiatry     Open Access  
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 8, SJR: 0.352, CiteScore: 1)
Annals of Saudi Medicine     Open Access   (SJR: 0.238, CiteScore: 1)
Annals of Thoracic Medicine     Open Access   (Followers: 6, SJR: 0.524, CiteScore: 1)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 13, SJR: 0.152, CiteScore: 0)
Annals of Tropical Pathology     Open Access  
Apollo Medicine     Open Access  
APOS Trends in Orthodontics     Open Access  
Arab J. of Interventional Radiology     Open Access  
Archives of Cardiovascular Imaging     Open Access   (Followers: 1, SJR: 0.187, CiteScore: 0)
Archives of Intl. Surgery     Open Access   (Followers: 10, SJR: 0.302, CiteScore: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Medicine and Surgery     Open Access  
Archives of Pharmacy Practice     Open Access   (Followers: 6, SJR: 0.102, CiteScore: 0)
Archives of Trauma Research     Open Access   (Followers: 3, SJR: 0.37, CiteScore: 2)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 4)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.856, CiteScore: 2)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.35, CiteScore: 1)
Asian Pacific J. of Reproduction     Open Access   (SJR: 0.227, CiteScore: 1)
Asian Pacific J. of Tropical Biomedicine     Open Access   (Followers: 2, SJR: 0.491, CiteScore: 2)
Asian Pacific J. of Tropical Medicine     Open Access   (Followers: 1, SJR: 0.561, CiteScore: 2)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
Biomedical and Biotechnology Research J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Canadian J. of Rural Medicine     Full-text available via subscription   (SJR: 0.202, CiteScore: 0)
Cancer Translational Medicine     Open Access   (Followers: 2)
Cardiology Plus     Open Access  
Chinese Medical J.     Open Access   (Followers: 10, SJR: 0.52, CiteScore: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Cancer Investigation J.     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 2)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 10, SJR: 0.811, CiteScore: 2)
Contemporary Clinical Dentistry     Open Access   (Followers: 4, SJR: 0.353, CiteScore: 1)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.543, CiteScore: 1)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.152, CiteScore: 0)
Dental Research J.     Open Access   (Followers: 11, SJR: 0.416, CiteScore: 1)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 6, SJR: 0.242, CiteScore: 0)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1, SJR: 1.799, CiteScore: 2)
Egyptian J. of Chest Diseases and Tuberculosis     Open Access   (Followers: 3, SJR: 0.155, CiteScore: 0)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.127, CiteScore: 0)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Nursing J.     Open Access  
Egyptian Orthopaedic J.     Open Access   (Followers: 2)
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.822, CiteScore: 2)
Environmental Disease     Open Access   (Followers: 3)
Eurasian J. of Pulmonology     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.749, CiteScore: 2)
European J. of General Dentistry     Open Access   (Followers: 1, SJR: 0.12, CiteScore: 0)
European J. of Prosthodontics     Open Access   (Followers: 3)
European J. of Psychology and Educational Studies     Open Access   (Followers: 11, SJR: 0.113, CiteScore: 0)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.112, CiteScore: 0)
Genome Integrity     Open Access   (Followers: 3, SJR: 0.153, CiteScore: 0)
Glioma     Open Access  
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Gynecology and Minimally Invasive Therapy     Open Access   (SJR: 0.311, CiteScore: 1)
Hamdan Medical J.     Open Access  
Heart and Mind     Open Access  
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
Ibnosina J. of Medicine and Biomedical Sciences     Open Access  
IJS Short Reports     Open Access  
Imam J. of Applied Sciences     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.478, CiteScore: 1)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (Followers: 1, SJR: 0.361, CiteScore: 1)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.37, CiteScore: 1)
Indian J. of Critical Care Medicine     Open Access   (Followers: 3, SJR: 0.604, CiteScore: 1)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.266, CiteScore: 1)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.468, CiteScore: 1)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 5, SJR: 0.445, CiteScore: 1)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1, SJR: 0.791, CiteScore: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4, SJR: 0.568, CiteScore: 1)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.425, CiteScore: 1)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.503, CiteScore: 1)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.656, CiteScore: 1)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.102, CiteScore: 0)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.347, CiteScore: 1)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.23, CiteScore: 0)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 3, SJR: 0.225, CiteScore: 1)
Indian J. of Ophthalmology     Open Access   (Followers: 4, SJR: 0.498, CiteScore: 1)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 8, SJR: 0.392, CiteScore: 1)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.199, CiteScore: 0)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.454, CiteScore: 1)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 2, SJR: 0.276, CiteScore: 1)
Indian J. of Pharmacology     Open Access   (SJR: 0.412, CiteScore: 1)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.311, CiteScore: 0)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.408, CiteScore: 1)
Indian J. of Psychological Medicine     Open Access   (SJR: 0.368, CiteScore: 1)
Indian J. of Public Health     Open Access   (Followers: 1)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Respiratory Care     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.119, CiteScore: 0)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.34, CiteScore: 0)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Transplantation     Open Access  
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Indian Spine J.     Open Access  
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intervention     Open Access   (Followers: 1)
Intl. Archives of Health Sciences     Open Access  
Intl. J. of Abdominal Wall and Hernia Surgery     Open Access   (Followers: 1)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Clinicopathological Correlation     Open Access  
Intl. J. of Community Dentistry     Open Access  
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1, SJR: 0.192, CiteScore: 0)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 3, SJR: 0.142, CiteScore: 0)
Intl. J. of Growth Factors and Stem Cells in Dentistry     Open Access  
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 6)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.535, CiteScore: 1)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4, SJR: 0.17, CiteScore: 0)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 2)
Intl. J. of Orofacial Biology     Open Access   (Followers: 1)
Intl. J. of Orofacial Research     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.623, CiteScore: 1)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 5, SJR: 0.653, CiteScore: 1)
Intl. J. of the Cardiovascular Academy     Open Access   (SJR: 0.105, CiteScore: 0)
Intl. J. of Trichology     Open Access   (SJR: 0.4, CiteScore: 1)
Intl. J. of Yoga     Open Access   (Followers: 14)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 5)

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Journal Cover
Chinese Medical Journal
Journal Prestige (SJR): 0.52
Citation Impact (citeScore): 1
Number of Followers: 10  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0366-6999 - ISSN (Online) 2542-5641
Published by Medknow Publishers Homepage  [429 journals]
  • Association between Nonalcoholic Fatty Liver Disease and Carotid Artery
           Disease in a Community-Based Chinese Population: A Cross-Sectional Study

    • Authors: Yu-Chen Guo, Yong Zhou, Xing Gao, Yan Yao, Bin Geng, Qing-Hua Cui, Ji-Chun Yang, Hong-Pu Hu
      Pages: 2269 - 2276
      Abstract: Yu-Chen Guo, Yong Zhou, Xing Gao, Yan Yao, Bin Geng, Qing-Hua Cui, Ji-Chun Yang, Hong-Pu Hu
      Chinese Medical Journal 2018 131(19):2269-2276
      Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases with a high prevalence in the general population. The association between NAFLD and cardiovascular disease has been well addressed in previous studies. However, whether NAFLD is associated with carotid artery disease in a community-based Chinese population remained unclear. The aim of this study was to investigate the association between NAFLD and carotid artery disease.Methods: A total of 2612 participants (1091 men and 1521 women) aged 40 years and older from Jidong of Tangshan city (China) were selected for this study. NAFLD was diagnosed by abdominal ultrasonography. The presence of carotid stenosis or plaque was evaluated by carotid artery ultrasonography. Logistic regression was used to analyze the association between NAFLD and carotid artery disease.Results: Participants with NAFLD have a higher prevalence of carotid stenosis (12.9% vs. 4.6%) and carotid plaque (21.9% vs. 15.0%) than those without NAFLD. After adjusting for age, gender, smoking status, income, physical activity, diabetes, hypertension, triglyceride, waist-hip ratio, and high-density lipoprotein, NAFLD is significantly associated with carotid stenosis (odds ratio [OR]: 2.06, 95% confidence interval [CI]: 1.45–2.91), but the association between NAFLD and carotid plaque is not statistically significant (OR: 1.10, 95% CI: 0.8–1.40).Conclusion: A significant association between NAFLD and carotid stenosis is found in a Chinese population.
      Citation: Chinese Medical Journal 2018 131(19):2269-2276
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241797
      Issue No: Vol. 131, No. 19 (2018)
       
  • Feasibility Analysis of Oxygen-Glucose Deprivation-Nutrition Resumption on
           H9c2 Cells In vitro Models of Myocardial Ischemia-Reperfusion Injury

    • Authors: Gui-Zhen Yang, Fu-Shan Xue, Ya-Yang Liu, Hui-Xian Li, Qing Liu, Xu Liao
      Pages: 2277 - 2286
      Abstract: Gui-Zhen Yang, Fu-Shan Xue, Ya-Yang Liu, Hui-Xian Li, Qing Liu, Xu Liao
      Chinese Medical Journal 2018 131(19):2277-2286
      Background: Oxygen-glucose deprivation-nutrition resumption (OGD-NR) models on H9c2 cells are commonly used in vitro models of simulated myocardial ischemia-reperfusion injury (MIRI), but no study has assessed whether these methods for establishing in vitro models can effectively imitate the characteristics of MIRI in vivo. This experiment was designed to analyze the feasibility of six OGD-NR models of MIRI.Methods: By searching the PubMed database using the keywords “myocardial reperfusion injury H9c2 cells,” we obtained six commonly used OGD-NR in vitro models of MIRI performed on H9c2 cells from more than 400 published papers before January 30, 2017. For each model, control (C), simulated ischemia (SI), and simulated ischemia-reperfusion (SIR) groups were assigned, and cell morphology, lactate dehydrogenase (LDH) release, adenosine triphosphate (ATP) levels, reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and inflammatory cytokines were examined to evaluate the characteristics of cell injury. Subsequently, a coculture system of cardiomyocyte-endothelial-macrophage was constructed. The coculture system was dealt with SI and SIR treatments to test the effect on cardiomyocytes survival.Results: For models 1, 2, 3, 4, 5, and 6, SI treatment caused morphological damage to cells, and subsequent SIR treatment did not cause further morphological damage. In the models 1, 2, 3, 4, 5 and 6, LDH release was significantly higher in the SI groups than that in the C group (P < 0.05), and was significantly lower in the SIR groups than that in the SI groups (P < 0.05), except for no significant differences in the LDH release between C, SI and SIR groups in model 6 receiving a 3-h SI treatment. In models 1, 2, 3, 4, 5, and 6, compared with the C group, ATP levels of the SI groups significantly decreased (P < 0.05), ROS levels increased (P < 0.05), and MMP levels decreased (P < 0.05). Compared with the SI group, ATP level of the SIR groups was significantly increased (P < 0.05), and there was no significant ROS production, MMP collapse, and over inflammatory response in the SIR groups. In a coculture system of H9c2 cells-endothelial cells-macrophages, the proportion of viable H9c2 cells in the SIR groups was not reduced compared with the SI groups.Conclusion: All the six OGD-NR models on H9c2 cells in this experiment can not imitate the characteristics of MIRI in vivo and are not suitable for MIRI-related study.
      Citation: Chinese Medical Journal 2018 131(19):2277-2286
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241809
      Issue No: Vol. 131, No. 19 (2018)
       
  • Effect of the Shensong Yangxin Capsule on Energy Metabolism in Angiotensin
           II-Induced Cardiac Hypertrophy

    • Authors: Bei-Lei Liu, Mian Cheng, Shan Hu, Shun Wang, Le Wang, Zheng-Qing Hu, Cong-Xin Huang, Hong Jiang, Gang Wu
      Pages: 2287 - 2296
      Abstract: Bei-Lei Liu, Mian Cheng, Shan Hu, Shun Wang, Le Wang, Zheng-Qing Hu, Cong-Xin Huang, Hong Jiang, Gang Wu
      Chinese Medical Journal 2018 131(19):2287-2296
      Background: Shensong Yangxin Capsule (SSYX), traditional Chinese medicine, has been used to treat arrhythmias, angina, cardiac remodeling, cardiac fibrosis, and so on, but its effect on cardiac energy metabolism is still not clear. The objective of this study was to investigate the effects of SSYX on myocardium energy metabolism in angiotensin (Ang) II-induced cardiac hypertrophy.Methods: We used 2 μl (10−6 mol/L) AngII to treat neonatal rat cardiomyocytes (NRCMs) for 48 h. Myocardial α-actinin staining showed that the myocardial cell volume increased. Expression of the cardiac hypertrophic marker-brain natriuretic peptide (BNP) messenger RNA (mRNA) also increased by real-time polymerase chain reaction (PCR). Therefore, it can be assumed that the model of hypertrophic cardiomyocytes was successfully constructed. Then, NRCMs were treated with 1 μl of different concentrations of SSYX (0.25, 0.5, and 1.0 μg/ml) for another 24 h. To explore the time-depend effect of SSYX on energy metabolism, 0.5 μg/ml SSYX was added into cells for 0, 6, 12, 24, and 48 h. Mitochondria was assessed by MitoTracker staining and confocal microscopy. mRNA and protein expression of mitochondrial biogenesis-related genes – Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), energy balance key factor – adenosine monophosphate-activated protein kinase (AMPK), fatty acids oxidation factor – carnitine palmitoyltransferase-1 (CPT-1), and glucose oxidation factor – glucose transporter- 4 (GLUT-4) were measured by PCR and Western blotting analysis.Results: With the increase in the concentration of SSYX (from 0.25 to 1.0 μg/ml), an increased mitochondrial density in AngII-induced cardiomyocytes was found compared to that of those treated with AngII only (0.25 μg/ml, 18.3300 ± 0.8895 vs. 24.4900 ± 0.9041, t = 10.240, P < 0.0001; 0.5 μg/ml, 18.3300 ± 0.8895 vs. 25.9800 ± 0.8187, t = 12.710, P < 0.0001; and 1.0 μg/ml, 18.3300 ± 0.8895 vs. 24.2900 ± 1.3120, t = 9.902, P < 0.0001; n = 5 per dosage group). SSYX also increased the mRNA and protein expression of PGC-1α (0.25 μg/ml, 0.8892 ± 0.0848 vs. 1.0970 ± 0.0994, t = 4.319, P = 0.0013; 0.5 μg/ml, 0.8892 ± 0.0848 vs. 1.2330 ± 0.0564, t = 7.150, P < 0.0001; and 1.0 μg/ml, 0.8892 ± 0.0848 vs. 1.1640 ± 0.0755, t = 5.720, P < 0.0001; n = 5 per dosage group), AMPK (0.25 μg/ml, 0.8872 ± 0.0779 vs. 1.1500 ± 0.0507, t = 7.239, P < 0.0001; 0.5 μg/ml, 0.8872 ± 0.0779 vs. 1.2280 ± 0.0623, t = 9.379, P < 0.0001; and 1.0 μg/ml, 0.8872 ± 0.0779 vs. 1.3020 ± 0.0450, t = 11.400, P < 0.0001; n = 5 per dosage group), CPT-1 (1.0 μg/ml, 0.7348 ± 0.0594 vs. 0.9880 ± 0.0851, t = 4.994, P = 0.0007, n = 5), and GLUT-4 (0.5 μg/ml, 1.5640 ± 0.0599 vs. 1.7720 ± 0.0660, t = 3.783, P = 0.0117; 1.0 μg/ml, 1.5640 ± 0.0599 vs. 2.0490 ± 0.1280, t = 8.808, P < 0.0001; n = 5 per dosage group). The effect became more obvious with the increasing concentration of SSYX. When 0.5 μg/ml SSYX was added into cells for 0, 6, 12, 24, and 48 h, the expression of AMPK (6 h, 14.6100 ± 0.6205 vs. 16.5200 ± 0.7450, t = 3.456, P = 0.0250; 12 h, 14.6100 ± 0.6205 vs. 18.3200 ± 0.9965, t = 6.720, P < 0.0001; 24 h, 14.6100 ± 0.6205 vs. 21.8800 ± 0.8208, t = 13.160, P < 0.0001; and 48 h, 14.6100 ± 0.6205 vs. 23.7400 ± 1.0970, t = 16.530, P < 0.0001; n = 5 per dosage group), PGC-1α (12 h, 11.4700 ± 0.7252 vs. 16.9000 ± 1.0150, t = 7.910, P < 0.0001; 24 h, 11.4700 ± 0.7252 vs. 20.8800 ± 1.2340, t = 13.710, P < 0.0001; and 48 h, 11.4700 ± 0.7252 vs. 22.0300 ± 1.4180, t = 15.390; n = 5 per dosage group), CPT-1 (24 h, 15.1600 ± 1.0960 vs. 18.5800 ± 0.9049, t = 6.048, P < 0.0001, n = 5), and GLUT-4 (6 h, 10.2100 ± 0.9485 vs. 12.9700 ± 0.8221, t = 4.763, P = 0.0012; 12 h, 10.2100 ± 0.9485 vs. 16.9100 ± 0.8481, t = 11.590, P < 0.0001; 24 h, 10.2100 ± 0.9485 vs. 19.0900 ± 0.9797, t = 15.360, P < 0.0001; and 48 h, 10.2100 ± 0.9485 vs. 14.1900 ± 0.9611, t = 6.877, P < 0.0001; n = 5 per dosage group) mRNA and protein increased gradually with the prolongation of drug action time.Conclusions: SSYX could increase myocardial energy metabolism in AngII-induced cardiac hypertrophy. Therefore, SSYX might be considered to be an alternative therapeutic remedy for myocardial hypertrophy.
      Citation: Chinese Medical Journal 2018 131(19):2287-2296
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241819
      Issue No: Vol. 131, No. 19 (2018)
       
  • Effects of Risperidone and Paliperidone on Brain-Derived Neurotrophic
           Factor and N400 in First-Episode Schizophrenia

    • Authors: Rong-Qin Wu, Chong-Guang Lin, Wei Zhang, Xiao-Dong Lin, Xing-Shi Chen, Ce Chen, Li-Jun Zhang, Zi-Ye Huang, Guang-Dong Chen, Da-Li Xu, Zhi-Guang Lin, Ming-Dao Zhang
      Pages: 2297 - 2301
      Abstract: Rong-Qin Wu, Chong-Guang Lin, Wei Zhang, Xiao-Dong Lin, Xing-Shi Chen, Ce Chen, Li-Jun Zhang, Zi-Ye Huang, Guang-Dong Chen, Da-Li Xu, Zhi-Guang Lin, Ming-Dao Zhang
      Chinese Medical Journal 2018 131(19):2297-2301
      Background: Risperidone and paliperidone have been the mainstay treatment for schizophrenia and their potential role in neuroprotection could be associated with brain-derived neurotrophic factor (BDNF) and N400 (an event-related brain potential component). So far, different effects on both BDNF and N400 were reported in relation to various antipsychotic treatments. However, few studies have been conducted on the mechanism of risperidone and paliperidone on BDNF and N400. This study aimed to compare the effects of risperidone and paliperidone on BDNF and the N400 component of the event-related brain potential in patients with first-episode schizophrenia.Methods: Ninety-eight patients with first-episode schizophrenia were randomly divided into the risperidone and paliperidone groups and treated with risperidone and paliperidone, respectively, for 12 weeks. Serum BDNF level, the latency, and amplitude of the N400 event-related potential before and after the treatment and Positive and Negative Syndrome Scale (PANSS) scores were compared between the two groups.Results: A total of 94 patients were included in the final analysis (47 patients in each group). After the treatment, the serum BDNF levels in both groups increased (all P < 0.01), while no significant difference in serum BDNF level was found between the groups before and after the treatment (all P > 0.05). After the treatment, N400 amplitudes were increased (from 4.73 ± 2.86 μv and 4.51 ± 4.63 μv to 5.35 ± 4.18 μv and 5.52 ± 3.08 μv, respectively) under congruent condition in both risperidone and paliperidone groups (all P < 0.01). Under incongruent conditions, the N400 latencies were shortened in the paliperidone group (from 424.13 ± 110.42 ms to 4.7.41 ± 154.59 ms, P < 0.05), and the N400 amplitudes were increased in the risperidone group (from 5.80 ± 3.50 μv to 7.17 ± 5.51 μv, P < 0.01). After treatment, the total PANSS score in both groups decreased significantly (all P < 0.01), but the difference between the groups was not significant (P > 0.05). A negative correlation between the reduction rate of the PANSS score and the increase in serum BDNF level after the treatment was found in the paliperidone group but not in the risperidone group.Conclusions: Both risperidone and paliperidone could increase the serum BDNF levels in patients with first-episode schizophrenia and improve their cognitive function (N400 latency and amplitude), but their antipsychotic mechanisms might differ.
      Citation: Chinese Medical Journal 2018 131(19):2297-2301
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241802
      Issue No: Vol. 131, No. 19 (2018)
       
  • Cardiac Fibroblast-Specific Activating Transcription Factor 3 Promotes
           Myocardial Repair after Myocardial Infarction

    • Authors: Yu-Lin Li, Wen-Jing Hao, Bo-Ya Chen, Jing Chen, Guo-Qi Li
      Pages: 2302 - 2309
      Abstract: Yu-Lin Li, Wen-Jing Hao, Bo-Ya Chen, Jing Chen, Guo-Qi Li
      Chinese Medical Journal 2018 131(19):2302-2309
      Background: Myocardial ischemia injury is one of the leading causes of death and disability worldwide. Cardiac fibroblasts (CFs) have central roles in modulating cardiac function under pathophysiological conditions. Activating transcription factor 3 (ATF3) plays a self-protective role in counteracting CF dysfunction. However, the precise function of CF-specific ATF3 during myocardial infarction (MI) injury/repair remains incompletely understood. The aim of this study was to determine whether CF-specific ATF3 affected cardiac repair after MI.Methods: Fifteen male C57BL/6 wild-type mice were performed with MI operation to observe the expression of ATF3 at 0, 0.5, 1.0, 3.0, and 7.0 days postoperation. Model for MI was constructed in ATF3TGfl/flCol1a2-Cre+ (CF-specific ATF3 overexpression group, n = 5) and ATF3TGfl/flCol1a2-Cre− male mice (without CF-specific ATF3 overexpression group, n = 5). In addition, five mice of ATF3TGfl/flCol1a2-Cre+ and ATF3TGfl/flCol1a2-Cre− were subjected to sham MI operation. Heart function was detected by ultrasound and left ventricular remodeling was observed by Masson staining (myocardial fibrosis area was detected by blue collagen deposition area) at the 28th day after MI surgery in ATF3TGfl/flCol1a2-Cre+ and ATF3TGfl/flCol1a2-Cre− mice received sham or MI operation. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect cell proliferation/cell cycle-related gene expression in cardiac tissue. BrdU staining was used to detect fibroblast proliferation.Results: After establishment of an MI model, we found that ATF3 proteins were increased in the heart of mice after MI surgery and dominantly expressed in CFs. Genetic overexpression of ATF3 in CFs (ATF3TGfl/flCol1a2-Cre+ group) resulted in an improvement in the heart function as indicated by increased cardiac ejection fraction (41.0% vs. 30.5%, t = 8.610, P = 0.001) and increased fractional shortening (26.8% vs. 18.1%, t = 7.173, P = 0.002), which was accompanied by a decrease in cardiac scar area (23.1% vs. 11.0%, t = 8.610, P = 0.001). qRT-PCR analysis of CFs isolated from ATF3TGfl/flCol1a2-Cre+ and ATF3TGfl/flCol1a2-Cre− ischemic hearts revealed a distinct transcriptional profile in ATF3-overexpressing CFs, displaying pro-proliferation properties. BrdU-positive cells significantly increased in ATF3-overexpressing CFs than control CFs under angiotensin II stimuli (11.5% vs. 6.8%, t = 31.599, P = 0.001) or serum stimuli (31.6% vs. 20.1%, t = 31.599, P = 0.001). The 5(6)-carboxyfluorescein N-hydroxysuccinimidyl ester assay showed that the cell numbers of the P2 and P3 generations were higher in the ATF3-overexpressing CFs at 24 h (P2: 91.6% vs. 71.8%, t = 8.465, P = 0.015) and 48 h (P3: 81.6% vs. 51.1%, t = 9.029, P = 0.012) after serum stimulation. Notably, ATF3 overexpression-induced CF proliferation was clearly increased in the heart after MI injury.Conclusions: We identify that CF-specific ATF3 might contribute to be MI repair through upregulating the expression of cell cycle/proliferation-related genes and enhancing cell proliferation.
      Citation: Chinese Medical Journal 2018 131(19):2302-2309
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241794
      Issue No: Vol. 131, No. 19 (2018)
       
  • Role of X-Box Binding Protein-1 in Fructose-Induced De Novo Lipogenesis in
           HepG2 Cells

    • Authors: Xian Yu, Lu-Ping Ren, Chao Wang, Ya-Jun Zhu, Han-Ying Xing, Jing Zhao, Guang-Yao Song
      Pages: 2310 - 2319
      Abstract: Xian Yu, Lu-Ping Ren, Chao Wang, Ya-Jun Zhu, Han-Ying Xing, Jing Zhao, Guang-Yao Song
      Chinese Medical Journal 2018 131(19):2310-2319
      Background: A high consumption of fructose leads to hepatic steatosis. About 20–30% of triglycerides are synthesized via de novo lipogenesis. Some studies showed that endoplasmic reticulum stress (ERS) is involved in this process, while others showed that a lipotoxic environment directly influences ER homeostasis. Here, our aim was to investigate the causal relationship between ERS and fatty acid synthesis and the effect of X-box binding protein-1 (XBP-1), one marker of ERS, on hepatic lipid accumulation stimulated by high fructose.Methods: HepG2 cells were incubated with different concentrations of fructose. Upstream regulators of de novo lipogenesis (i.e., carbohydrate response element-binding protein [ChREBP] and sterol regulatory element-binding protein 1c [SREBP-1c]) were measured by polymerase chain reaction and key lipogenic enzymes (acetyl-CoA carboxylase [ACC], fatty acid synthase [FAS], and stearoyl-CoA desaturase-1 [SCD-1]) by Western blotting. The same lipogenesis-associated factors were then evaluated after exposure of HepG2 cells to high fructose followed by the ERS inhibitor tauroursodeoxycholic acid (TUDCA) or the ERS inducer thapsigargin. Finally, the same lipogenesis-associated factors were evaluated in HepG2 cells after XBP-1 upregulation or downregulation through cell transfection.Results: Exposure to high fructose increased triglyceride levels in a dose- and time-dependent manner and significantly increased mRNA levels of SREBP-1c and ChREBP and protein levels of FAS, ACC, and SCD-1, concomitant with XBP-1 conversion to an active spliced form. Lipogenesis-associated factors induced by high fructose were inhibited by TUDCA and induced by thapsigargin. Triglyceride level in XBP-1-deficient group decreased significantly compared with high-fructose group (4.41 ± 0.54 μmol/g vs. 6.52 ± 0.38 μmol/g, P < 0.001), as mRNA expressions of SREBP-1c (2.92 ± 0.46 vs. 5.08 ± 0.41, P < 0.01) and protein levels of FAS (0.53 ± 0.06 vs. 0.85 ± 0.05, P = 0.01), SCD-1 (0.65 ± 0.06 vs. 0.90 ± 0.04, P = 0.04), and ACC (0.38 ± 0.03 vs. 0.95 ± 0.06, P < 0.01) decreased. Conversely, levels of triglyceride (4.22 ± 0.54 μmol/g vs. 2.41 ± 0.35 μmol/g, P < 0.001), mRNA expression of SREBP-1c (2.70 ± 0.33 vs. 1.00 ± 0.00, P < 0.01), and protein expression of SCD-1 (0.93 ± 0.06 vs. 0.26 ± 0.05, P < 0.01), ACC (0.98 ± 0.09 vs. 0.43 ± 0.03, P < 0.01), and FAS (0.90 ± 0.33 vs. 0.71 ± 0.02, P = 0.04) in XBP-1s-upregulated group increased compared with the untransfected group.Conclusions: ERS is associated with de novo lipogenesis, and XBP-1 partially mediates high-fructose-induced lipid accumulation in HepG2 cells through augmentation of de novo lipogenesis.
      Citation: Chinese Medical Journal 2018 131(19):2310-2319
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241799
      Issue No: Vol. 131, No. 19 (2018)
       
  • XB130 Knockdown Inhibits the Proliferation, Invasiveness, and Metastasis
           of Hepatocellular Carcinoma Cells and Sensitizes them to TRAIL-Induced
           Apoptosis

    • Authors: Guang-Ming Li, Chao-Jie Liang, Dong-Xin Zhang, Li-Jun Zhang, Ji-Xiang Wu, Ying-Chen Xu
      Pages: 2320 - 2331
      Abstract: Guang-Ming Li, Chao-Jie Liang, Dong-Xin Zhang, Li-Jun Zhang, Ji-Xiang Wu, Ying-Chen Xu
      Chinese Medical Journal 2018 131(19):2320-2331
      Background: XB130 is a recently discovered adaptor protein that is highly expressed in many malignant tumors, but few studies have investigated its role in hepatocellular carcinoma (HCC). Therefore, this study explored the relationship between this protein and liver cancer and investigated its molecular mechanism of action.Methods: The expression of XB130 between HCC tissues and adjacent nontumor tissues was compared by real-time polymerase chain reaction, immunochemistry, and Western blotting. XB130 silencing was performed using small hairpin RNA. The effect of silencing XB130 was examined using Cell Counting Kit-8, colony assay, wound healing assay, and cell cycle analysis.Results: We found that XB130 was highly expressed in HCC tissues (cancer tissues vs. adjacent tissues: 0.23 ± 0.02 vs. 0.17 ± 0.02, P < 0.05) and liver cancer cell lines, particularly MHCC97H and HepG2 (MHCC97H and HepG2 vs. normal liver cell line LO-2: 2.35 ± 0.26 and 2.04 ± 0.04 vs. 1.00 ± 0.04, respectively, all P < 0.05). The Cell Counting Kit-8 assay, colony formation assay, and xenograft model in nude mice showed that silencing XB130 inhibited cell proliferative ability both in vivo and in vitro, with flow cytometry demonstrating that the cells were arrested in the G0/G1 phase in HepG2 (HepG2 XB130-silenced group [shA] vs. HepG2 scramble group [NA]: 74.32 ± 5.86% vs. 60.21 ± 3.07%, P < 0.05) and that the number of G2/M phase cells was decreased (HepG2 shA vs. HepG2 NA: 8.06 ± 2.41% vs. 18.36 ± 4.42%, P < 0.05). Furthermore, the cell invasion and migration abilities were impaired, and the levels of the epithelial-mesenchymal transition-related indicators vimentin and N-cadherin were decreased, although the level of E-cadherin was increased after silencing XB130. Western blotting showed that the levels of phosphorylated phosphoinositide 3-kinase (PI3K) and phospho-protein kinase B (p-Akt) also increased, although the level of phosphorylated phosphatase and tensin homolog increased, indicating that XB130 activated the PI3K/Akt pathway. Furthermore, we found that a reduction in XB130 increased liver cancer cell sensitivity to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.Conclusions: Our findings suggest that XB130 might be used as a predictor of liver cancer as well as one of the targets for its treatment.
      Citation: Chinese Medical Journal 2018 131(19):2320-2331
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241800
      Issue No: Vol. 131, No. 19 (2018)
       
  • Advances in the Surgical Treatment of Neuroblastoma

    • Authors: Yan-Bing Luo, Xi-Chun Cui, Lin Yang, Da Zhang, Jia-Xiang Wang
      Pages: 2332 - 2337
      Abstract: Yan-Bing Luo, Xi-Chun Cui, Lin Yang, Da Zhang, Jia-Xiang Wang
      Chinese Medical Journal 2018 131(19):2332-2337
      Objective: This study was to review the efficacy of surgical resections in different clinical situations for a better understanding of the meaning of surgery in the treatment of neuroblastoma (NB).Data Sources: The online database ScienceDirect (201–2018) was utilized. The search was conducted using the keywords “neuroblastoma,” “neuroblastoma resection,” “neuroblastoma surgery,” and “high-risk neuroblastoma.”Study Selection: We retrospectively analyzed of patients who underwent surgical resections in different clinical situations. The article included findings from selected relevant randomized controlled trials, systematic reviews, and meta-analyses or good-quality observational studies. s only, letters, and editorial notes were excluded. Full-text articles and abstracts were extracted and reviewed to identify key articles discussing surgery management of NB, which were then selected for critical analysis.Results: A total of 7800 English language articles were found containing references to NB (201–2018). The 163 articles were searched which were related to the surgical treatment of NB (201–2018). Through the analysis of these important articles, we found that the treatments of NB at low- and intermediate-risk groups were basically the same. High-risk patients remained controversial.Conclusions: NB prognosis varies tremendously based on the stage and biologic features of the tumor. After reviewing the relevant literature, patients with low-risk disease are often managed with surgical resection or observation alone with tumors likely to spontaneously regress that are not causing symptoms. Intermediate patients are treated with chemotherapy with the number of cycles depending on their response as well as surgical resection of the primary tumor. High-risk patients remain controversial. Multidisciplinary intensive treatment is essential, especially for patients who received subtotal tumor resection. Minimally invasive surgery for the treatment of NBs without image-defined risk factors in low- to high-risk patients is safe and feasible and does not compromise the treatment outcome. We conclude that ≥90% resection of the primary tumor is both feasible and safe in most patients with high-risk NB. New targeted therapies are crucial to improve survival.
      Citation: Chinese Medical Journal 2018 131(19):2332-2337
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241803
      Issue No: Vol. 131, No. 19 (2018)
       
  • Common Injuries and Repair Mechanisms in the Endothelial Lining

    • Authors: Ling-Bing Meng, Kun Chen, Yuan-Meng Zhang, Tao Gong
      Pages: 2338 - 2345
      Abstract: Ling-Bing Meng, Kun Chen, Yuan-Meng Zhang, Tao Gong
      Chinese Medical Journal 2018 131(19):2338-2345
      Objective: Endothelial cells (ECs) are important metabolic and endocrinal organs which play a significant role in regulating vascular function. Vascular ECs, located between the blood and vascular tissues, can not only complete the metabolism of blood and interstitial fluid but also synthesize and secrete a variety of biologically active substances to maintain vascular tension and keep a normal flow of blood and long-term patency. Therefore, this article presents a systematic review of common injuries and healing mechanisms for the vascular endothelium.Data Sources: An extensive search in the PubMed database was undertaken, focusing on research published after 2003 with keywords including endothelium, vascular, wounds and injuries, and wound healing.Study Selection: Several types of articles, including original studies and literature reviews, were identified and reviewed to summarize common injury and repair processes of the endothelial lining.Results: Endothelial injury is closely related to the development of multiple cardiovascular and cerebrovascular diseases. However, the mechanism of vascular endothelial injury is not fully understood. Numerous studies have shown that the mechanisms of EC injury mainly involve inflammatory reactions, physical stimulation, chemical poisons, concurrency of related diseases, and molecular changes. Endothelial progenitor cells play an important role during the process of endothelial repair after such injuries. What's more, a variety of restorative cells, changes in cytokines and molecules, chemical drugs, certain RNAs, regulation of blood pressure, and physical fitness training protect the endothelial lining by reducing the inducing factors, inhibiting inflammation and oxidative stress reactions, and delaying endothelial caducity.Conclusions: ECs are always in the process of being damaged. Several therapeutic targets and drugs were seeked to protect the endothelium and promote repair.
      Citation: Chinese Medical Journal 2018 131(19):2338-2345
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241805
      Issue No: Vol. 131, No. 19 (2018)
       
  • Emergent Endoscopic Retrograde Cholangiopancreatography with Placement of
           Biliary Double Stents to Salvage Endoscopic Retrograde
           Cholangiopancreatography-Induced Stapfer's Type II Perforation

    • Authors: Ping Yue, Wen-Bo Meng, Joseph W Leung, Lei Zhang, Xiao-Liang Zhu, Hui Zhang, Hai-Ping Wang, Zheng-Feng Wang, Ke-Xiang Zhu, Long Miao, Wen-Ce Zhou, Xun Li
      Pages: 2346 - 2348
      Abstract: Ping Yue, Wen-Bo Meng, Joseph W Leung, Lei Zhang, Xiao-Liang Zhu, Hui Zhang, Hai-Ping Wang, Zheng-Feng Wang, Ke-Xiang Zhu, Long Miao, Wen-Ce Zhou, Xun Li
      Chinese Medical Journal 2018 131(19):2346-2348

      Citation: Chinese Medical Journal 2018 131(19):2346-2348
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241798
      Issue No: Vol. 131, No. 19 (2018)
       
  • Complete Closure of Gastric Defect with Improved Purse-String Suture
           Technique Using Single-Channel Endoscope

    • Authors: Min Lin, Qiang Wang, Feng-Dong Li, Rui Li, Jin Huang
      Pages: 2349 - 2351
      Abstract: Min Lin, Qiang Wang, Feng-Dong Li, Rui Li, Jin Huang
      Chinese Medical Journal 2018 131(19):2349-2351

      Citation: Chinese Medical Journal 2018 131(19):2349-2351
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241817
      Issue No: Vol. 131, No. 19 (2018)
       
  • Association between Age-Related Macular Degeneration and Lens Opacity in
           Senior Population in Hainan Province

    • Authors: Kai-Yan Zhang, Qiong-Lei Zhong, Yan Xu, Chuan-Xian Guo, Si-Ying Chen, Yi-Jie Yan, Xiao-Ling Wu, Yun-Suo Gao
      Pages: 2352 - 2353
      Abstract: Kai-Yan Zhang, Qiong-Lei Zhong, Yan Xu, Chuan-Xian Guo, Si-Ying Chen, Yi-Jie Yan, Xiao-Ling Wu, Yun-Suo Gao
      Chinese Medical Journal 2018 131(19):2352-2353

      Citation: Chinese Medical Journal 2018 131(19):2352-2353
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241816
      Issue No: Vol. 131, No. 19 (2018)
       
  • Causes of Severe Visual Impairment and Blindness in Schools for the Blind

    • Authors: Hui-Yi Jin, Jiang-Nan He, Jian-Feng Zhu, Shan-Shan Li, Li-Na Lu, Xian-Gui He, Hong-Mei Xu, Xun-Jie Chen, Hai-Dong Zou
      Pages: 2354 - 2356
      Abstract: Hui-Yi Jin, Jiang-Nan He, Jian-Feng Zhu, Shan-Shan Li, Li-Na Lu, Xian-Gui He, Hong-Mei Xu, Xun-Jie Chen, Hai-Dong Zou
      Chinese Medical Journal 2018 131(19):2354-2356

      Citation: Chinese Medical Journal 2018 131(19):2354-2356
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241812
      Issue No: Vol. 131, No. 19 (2018)
       
  • Systemic-Related Factors of Nonarteritic Anterior Ischemic Optic
           Neuropathy

    • Authors: Yue-Yan Xiao, Wen-Bin Wei, Ya-Xing Wang, Ai-Dong Lu, Shuo-Hua Chen, Lu Song, Shou-Ling Wu
      Pages: 2357 - 2359
      Abstract: Yue-Yan Xiao, Wen-Bin Wei, Ya-Xing Wang, Ai-Dong Lu, Shuo-Hua Chen, Lu Song, Shou-Ling Wu
      Chinese Medical Journal 2018 131(19):2357-2359

      Citation: Chinese Medical Journal 2018 131(19):2357-2359
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241795
      Issue No: Vol. 131, No. 19 (2018)
       
  • Effects of Nerve Growth Factor Expression on Perineural Invasion and Worse
           Prognosis in Early-Stage Cervical Cancer

    • Authors: Ying Long, De-Sheng Yao, You-Sheng Wei, Guang-Teng Wu
      Pages: 2360 - 2363
      Abstract: Ying Long, De-Sheng Yao, You-Sheng Wei, Guang-Teng Wu
      Chinese Medical Journal 2018 131(19):2360-2363

      Citation: Chinese Medical Journal 2018 131(19):2360-2363
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241808
      Issue No: Vol. 131, No. 19 (2018)
       
  • Successful Laparoscopic Management of Heterotopic Pregnancy at
           12&#43;2 Weeks of Gestation

    • Authors: Yao Xie, Xia Zhao
      Pages: 2364 - 2365
      Abstract: Yao Xie, Xia Zhao
      Chinese Medical Journal 2018 131(19):2364-2365

      Citation: Chinese Medical Journal 2018 131(19):2364-2365
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241820
      Issue No: Vol. 131, No. 19 (2018)
       
  • Inversion of the Uterus Combined with Endometrial Carcinosarcoma

    • Authors: Huan-Huan Zhao, Jian-Xin Cheng, Li Li
      Pages: 2366 - 2367
      Abstract: Huan-Huan Zhao, Jian-Xin Cheng, Li Li
      Chinese Medical Journal 2018 131(19):2366-2367

      Citation: Chinese Medical Journal 2018 131(19):2366-2367
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241806
      Issue No: Vol. 131, No. 19 (2018)
       
  • Severe Hyperhomocysteinemia with Two Novel Mutations of c.154T>C and
           c.457G>A in Cystathionine Beta-Synthase Gene

    • Authors: Hong An, Chun-Qiu Fan, Jian-Gang Duan, Yi Ren, Kai Dong, Qian Zhang, Xun-Ming Ji, Xiao-Qin Huang
      Pages: 2368 - 2370
      Abstract: Hong An, Chun-Qiu Fan, Jian-Gang Duan, Yi Ren, Kai Dong, Qian Zhang, Xun-Ming Ji, Xiao-Qin Huang
      Chinese Medical Journal 2018 131(19):2368-2370

      Citation: Chinese Medical Journal 2018 131(19):2368-2370
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241801
      Issue No: Vol. 131, No. 19 (2018)
       
  • Giant Axonal Neuropathy with Unusual Neuroimagings Caused by Compound
           Heterozygous Mutations in GAN Gene

    • Authors: Shuang Cai, Jie Lin, Yi-Qi Liu, Jia-Hong Lu, Chong-Bo Zhao
      Pages: 2371 - 2372
      Abstract: Shuang Cai, Jie Lin, Yi-Qi Liu, Jia-Hong Lu, Chong-Bo Zhao
      Chinese Medical Journal 2018 131(19):2371-2372

      Citation: Chinese Medical Journal 2018 131(19):2371-2372
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241804
      Issue No: Vol. 131, No. 19 (2018)
       
  • B/S Brace as an Alternative Treatment for Ingrown Toenails

    • Authors: Fei Miao, Shu Nie, Hong-Wei Wang
      Pages: 2373 - 2375
      Abstract: Fei Miao, Shu Nie, Hong-Wei Wang
      Chinese Medical Journal 2018 131(19):2373-2375

      Citation: Chinese Medical Journal 2018 131(19):2373-2375
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241807
      Issue No: Vol. 131, No. 19 (2018)
       
  • Clinical and Genetic Features of Familial Cold Urticaria: A Report of
           Three Families

    • Authors: Kai Wang, Lin-Feng Li
      Pages: 2376 - 2377
      Abstract: Kai Wang, Lin-Feng Li
      Chinese Medical Journal 2018 131(19):2376-2377

      Citation: Chinese Medical Journal 2018 131(19):2376-2377
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241813
      Issue No: Vol. 131, No. 19 (2018)
       
  • A Case Report on Acquired Tufted Angioma with Severe Pain after Healed
           Herpes Zoster

    • Authors: Yu-Tian Cai, Hui Xu, Yuan Guo, Ning-Ning Guo, Yu-Mei Li
      Pages: 2378 - 2379
      Abstract: Yu-Tian Cai, Hui Xu, Yuan Guo, Ning-Ning Guo, Yu-Mei Li
      Chinese Medical Journal 2018 131(19):2378-2379

      Citation: Chinese Medical Journal 2018 131(19):2378-2379
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241796
      Issue No: Vol. 131, No. 19 (2018)
       
  • Genomic Disruption of FOXL2 in Blepharophimosis-Ptosis-Epicanthus Inversus
           Syndrome Type 2: A Novel Deletion-Insertion Compound Mutation

    • Authors: Bei-Bei Niu, Ning Tang, Qin Xu, Pei-Wei Chai
      Pages: 2380 - 2383
      Abstract: Bei-Bei Niu, Ning Tang, Qin Xu, Pei-Wei Chai
      Chinese Medical Journal 2018 131(19):2380-2383

      Citation: Chinese Medical Journal 2018 131(19):2380-2383
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241818
      Issue No: Vol. 131, No. 19 (2018)
       
  • A New Mutation Identified by Whole Exome Sequencing in a Cornelia de Lange
           Syndrome Newborn

    • Authors: Hua Zhang, Li-Ming Yang, Lu Yuan, Xin Tan, Fu-Qing Zhang
      Pages: 2384 - 2385
      Abstract: Hua Zhang, Li-Ming Yang, Lu Yuan, Xin Tan, Fu-Qing Zhang
      Chinese Medical Journal 2018 131(19):2384-2385

      Citation: Chinese Medical Journal 2018 131(19):2384-2385
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241793
      Issue No: Vol. 131, No. 19 (2018)
       
  • Diffuse Pulmonary Alveolar Hemorrhage Secondary to All-Trans-Retinoic Acid
           in Acute Promyelocytic Leukemia

    • Authors: Chen-Lu Yang, Kai Shen, Jie Huang
      Pages: 2386 - 2387
      Abstract: Chen-Lu Yang, Kai Shen, Jie Huang
      Chinese Medical Journal 2018 131(19):2386-2387

      Citation: Chinese Medical Journal 2018 131(19):2386-2387
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241815
      Issue No: Vol. 131, No. 19 (2018)
       
  • Access to Orphan Drugs is a Challenge for Sustainable Management of
           Cystinosis in China

    • Authors: Xiao-Qiao Li, Xiao-Xia Peng, Chun-Xiu Gong
      Pages: 2388 - 2389
      Abstract: Xiao-Qiao Li, Xiao-Xia Peng, Chun-Xiu Gong
      Chinese Medical Journal 2018 131(19):2388-2389

      Citation: Chinese Medical Journal 2018 131(19):2388-2389
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241814
      Issue No: Vol. 131, No. 19 (2018)
       
  • A Challenge: Pulmonary Sclerosing Haemangioma

    • Authors: Tong-Tong Li, Xu Yan, Tong Zhou, Zhen-Xiang Yu
      Pages: 2390 - 2391
      Abstract: Tong-Tong Li, Xu Yan, Tong Zhou, Zhen-Xiang Yu
      Chinese Medical Journal 2018 131(19):2390-2391

      Citation: Chinese Medical Journal 2018 131(19):2390-2391
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.239689
      Issue No: Vol. 131, No. 19 (2018)
       
  • Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis
           Syndrome

    • Authors: Nicholas G Kounis, Ioanna Koniari, Emmanouil Chourdakis, George D Soufras, Grigorios Tsigkas, Periklis Davlouros, George Hahalis
      Pages: 2392 - 2393
      Abstract: Nicholas G Kounis, Ioanna Koniari, Emmanouil Chourdakis, George D Soufras, Grigorios Tsigkas, Periklis Davlouros, George Hahalis
      Chinese Medical Journal 2018 131(19):2392-2393

      Citation: Chinese Medical Journal 2018 131(19):2392-2393
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241810
      Issue No: Vol. 131, No. 19 (2018)
       
  • Reply to “Acute Myocardial Infarction Induced by Anaphylaxis in
           China: The Kounis Syndrome”

    • Authors: Rui Tang, Jin-Lu Sun
      Pages: 2394 - 2394
      Abstract: Rui Tang, Jin-Lu Sun
      Chinese Medical Journal 2018 131(19):2394-2394

      Citation: Chinese Medical Journal 2018 131(19):2394-2394
      PubDate: Fri,21 Sep 2018
      DOI: 10.4103/0366-6999.241811
      Issue No: Vol. 131, No. 19 (2018)
       
 
 
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