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Publisher: Medknow Publishers   (Total: 427 journals)

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Showing 201 - 400 of 427 Journals sorted alphabetically
J. of Academy of Medical Sciences     Open Access  
J. of Acute Disease     Open Access   (SJR: 0.163, CiteScore: 1)
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 3, SJR: 0.309, CiteScore: 1)
J. of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 8, SJR: 0.612, CiteScore: 1)
J. of Applied Hematology     Open Access   (Followers: 1)
J. of Association of Chest Physicians     Open Access   (Followers: 2)
J. of Basic and Clinical Reproductive Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Therapeutics     Open Access   (Followers: 5, SJR: 0.4, CiteScore: 1)
J. of Carcinogenesis     Open Access   (Followers: 1, SJR: 0.662, CiteScore: 2)
J. of Cardiothoracic Trauma     Open Access  
J. of Cardiovascular Disease Research     Open Access   (Followers: 2, SJR: 0.13, CiteScore: 0)
J. of Cardiovascular Echography     Open Access   (Followers: 1, SJR: 0.135, CiteScore: 0)
J. of Cleft Lip Palate and Craniofacial Anomalies     Open Access   (Followers: 2)
J. of Clinical and Preventive Cardiology     Open Access   (Followers: 1)
J. of Clinical Imaging Science     Open Access   (Followers: 3, SJR: 0.281, CiteScore: 1)
J. of Clinical Neonatology     Open Access   (Followers: 3)
J. of Clinical Ophthalmology and Research     Open Access   (Followers: 2)
J. of Clinical Sciences     Open Access  
J. of Conservative Dentistry     Open Access   (Followers: 4, SJR: 0.507, CiteScore: 1)
J. of Craniovertebral Junction and Spine     Open Access   (Followers: 4, SJR: 0.327, CiteScore: 2)
J. of Current Medical Research and Practice     Open Access  
J. of Current Research in Scientific Medicine     Open Access  
J. of Cutaneous and Aesthetic Surgery     Open Access   (Followers: 1, SJR: 0.317, CiteScore: 1)
J. of Cytology     Open Access   (Followers: 1, SJR: 0.284, CiteScore: 1)
J. of Datta Meghe Institute of Medical Sciences University     Open Access   (SJR: 0.1, CiteScore: 0)
J. of Dental and Allied Sciences     Open Access   (Followers: 2)
J. of Dental Implants     Open Access   (Followers: 8)
J. of Dental Lasers     Open Access   (Followers: 2)
J. of Dental Research and Review     Open Access   (Followers: 1)
J. of Dermatology & Dermatologic Surgery     Open Access   (Followers: 1)
J. of Diabetology     Open Access   (Followers: 1)
J. of Digestive Endoscopy     Open Access   (Followers: 4)
J. of Dr. NTR University of Health Sciences     Open Access  
J. of Earth, Environment and Health Sciences     Open Access   (Followers: 2)
J. of Education and Ethics in Dentistry     Open Access   (Followers: 5)
J. of Education and Health Promotion     Open Access   (Followers: 6)
J. of Emergencies, Trauma and Shock     Open Access   (Followers: 10, SJR: 0.455, CiteScore: 1)
J. of Engineering and Technology     Open Access   (Followers: 6)
J. of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
J. of Family and Community Medicine     Open Access   (Followers: 3)
J. of Family Medicine and Primary Care     Open Access   (Followers: 12)
J. of Forensic Dental Sciences     Open Access   (Followers: 4)
J. of Forensic Science and Medicine     Open Access   (Followers: 15)
J. of Geriatric Mental Health     Open Access   (Followers: 3)
J. of Global Infectious Diseases     Open Access   (SJR: 0.735, CiteScore: 1)
J. of Head & Neck Physicians and Surgeons     Open Access   (Followers: 1)
J. of Health Research and Reviews     Open Access  
J. of Health Specialties     Open Access  
J. of HIV and Human Reproduction     Open Access   (Followers: 2)
J. of Human Health     Open Access  
J. of Human Reproductive Sciences (JHRS)     Open Access   (Followers: 3, SJR: 0.585, CiteScore: 1)
J. of Indian Academy of Dental Specialist Researchers     Open Access  
J. of Indian Academy of Oral Medicine and Radiology     Open Access   (Followers: 3)
J. of Indian Association of Pediatric Surgeons     Open Access   (Followers: 2, SJR: 0.304, CiteScore: 1)
J. of Indian Association of Public Health Dentistry     Open Access   (Followers: 2)
J. of Indian Orthodontic Society     Open Access   (Followers: 1)
J. of Indian Prosthodontic Society     Open Access   (Followers: 2, SJR: 0.319, CiteScore: 0)
J. of Indian Society of Pedodontics and Preventive Dentistry     Open Access   (Followers: 1, SJR: 0.427, CiteScore: 1)
J. of Indian Society of Periodontology     Open Access   (SJR: 0.335, CiteScore: 1)
J. of Indian Speech Language & Hearing Association     Open Access  
J. of Integrative Nephrology and Andrology     Open Access   (Followers: 2)
J. of Interdisciplinary Dentistry     Open Access   (Followers: 5)
J. of Intl. Oral Health     Open Access   (SJR: 0.12, CiteScore: 0)
J. of Intl. Society of Preventive and Community Dentistry     Open Access   (Followers: 3, SJR: 0.242, CiteScore: 1)
J. of Laboratory Physicians     Open Access   (Followers: 1)
J. of Laryngology and Voice     Open Access   (Followers: 10)
J. of Limb Lengthening & Reconstruction     Open Access  
J. of Mahatma Gandhi Institute of Medical Sciences     Open Access  
J. of Marine Medical Society     Open Access  
J. of Medical Investigation and Practice     Open Access  
J. of Medical Nutrition and Nutraceuticals     Open Access   (Followers: 2)
J. of Medical Physics     Open Access   (Followers: 6, SJR: 0.41, CiteScore: 1)
J. of Medical Sciences     Open Access   (SJR: 0.147, CiteScore: 0)
J. of Medical Signals and Sensors     Open Access   (Followers: 3, SJR: 0.277, CiteScore: 1)
J. of Medical Society     Open Access   (SJR: 0.165, CiteScore: 0)
J. of Medical Ultrasound     Open Access   (Followers: 2, SJR: 0.146, CiteScore: 0)
J. of Medicine in Scientific Research     Open Access  
J. of Medicine in the Tropics     Open Access  
J. of Mental Health and Human Behavior     Open Access   (Followers: 3)
J. of Microscopy and Ultrastructure : The J. of the Saudi Society of Microscopes     Open Access   (Followers: 1)
J. of Mid-life Health     Open Access   (SJR: 0.308, CiteScore: 1)
J. of Minimal Access Surgery     Open Access   (Followers: 1, SJR: 0.42, CiteScore: 1)
J. of Musculoskeletal Surgery and Research     Open Access  
J. of National Accreditation Board for Hospitals & Healthcare Providers     Open Access  
J. of Natural Science, Biology and Medicine     Open Access   (Followers: 1, SJR: 0.38, CiteScore: 1)
J. of Nature and Science of Medicine     Open Access   (Followers: 2)
J. of Neurosciences in Rural Practice     Open Access   (Followers: 1, SJR: 0.28, CiteScore: 0)
J. of Nursing and Midwifery Sciences     Open Access  
J. of Obesity and Metabolic Research     Open Access   (Followers: 6)
J. of Obstetric Anaesthesia and Critical Care     Open Access   (Followers: 18)
J. of Ophthalmic and Vision Research     Open Access   (SJR: 0.727, CiteScore: 1)
J. of Oral and Maxillofacial Pathology     Open Access   (Followers: 3, SJR: 0.351, CiteScore: 1)
J. of Oral and Maxillofacial Radiology     Open Access   (Followers: 1)
J. of Oral Research and Review     Open Access  
J. of Orofacial Sciences     Open Access   (SJR: 0.139, CiteScore: 0)
J. of Orthodontic Research     Open Access   (Followers: 2)
J. of Orthodontic Science     Open Access   (Followers: 2)
J. of Orthopaedics and Allied Sciences     Open Access   (Followers: 7)
J. of Orthopedics, Traumatology and Rehabilitation     Open Access   (Followers: 6)
J. of Pathology Informatics     Open Access   (Followers: 1, SJR: 0.639, CiteScore: 2)
J. of Patient Safety & Infection Control     Open Access   (Followers: 8)
J. of Pediatric Dentistry     Open Access   (Followers: 3)
J. of Pediatric Neurosciences     Open Access   (Followers: 5, SJR: 0.253, CiteScore: 1)
J. of Pharmaceutical Negative Results     Open Access   (Followers: 1, SJR: 0.151, CiteScore: 0)
J. of Pharmacology & Pharmacotherapeutics     Open Access   (Followers: 1, SJR: 0.476, CiteScore: 1)
J. of Pharmacy and Bioallied Sciences     Open Access   (Followers: 2, SJR: 0.338, CiteScore: 1)
J. of Postgraduate Medicine     Open Access   (SJR: 0.303, CiteScore: 1)
J. of Radiation and Cancer Research     Open Access  
J. of Renal Nutrition and Metabolism     Open Access  
J. of Reports in Pharmaceutical Sciences     Open Access   (SJR: 0.16, CiteScore: 0)
J. of Research in Medical Sciences     Open Access   (Followers: 2, SJR: 0.593, CiteScore: 2)
J. of Research in Pharmacy Practice     Open Access   (Followers: 3, SJR: 2.211, CiteScore: 0)
J. of Restorative Dentistry     Open Access   (Followers: 2)
J. of Spinal Studies and Surgery     Open Access  
J. of Surgical Technique and Case Report     Open Access  
J. of The Academy of Clinical Microbiologists     Open Access  
J. of The Arab Society for Medical Research     Open Access  
J. of the Egyptian Ophthalmological Society     Open Access  
J. of The Egyptian Society of Nephrology and Transplantation     Open Access  
J. of The Indian Academy of Echocardiography & Cardiovascular Imaging     Open Access   (Followers: 1)
J. of the Intl. Clinical Dental Research Organization     Open Access  
J. of the Practice of Cardiovascular Sciences     Open Access  
J. of the Scientific Society     Open Access   (Followers: 1)
J. of Vector Borne Diseases     Open Access   (SJR: 0.604, CiteScore: 1)
J. of Young Pharmacists     Open Access   (Followers: 2, SJR: 0.306, CiteScore: 1)
Karnataka Anaesthesia J.     Open Access   (Followers: 1)
Kasr Al Ainy Medical J.     Open Access   (Followers: 1)
Kerala J. of Ophthalmology     Open Access  
Libyan Intl. Medical University J.     Open Access   (Followers: 2)
Libyan J. of Medical Sciences     Open Access  
Lung India     Open Access   (SJR: 0.379, CiteScore: 1)
MAMC J. of Medical Sciences     Open Access  
Medical Gas Research     Open Access   (Followers: 3, SJR: 0.658, CiteScore: 3)
Medical J. of Babylon     Open Access  
Medical J. of Dr. D.Y. Patil University     Open Access  
Medical J. of Dr. D.Y. Patil Vidyapeeth     Open Access  
Medical Law Cases for Doctors     Open Access   (Followers: 5)
Menoufia Medical J.     Open Access   (Followers: 2)
Mens Sana Monographs     Open Access   (SJR: 0.11, CiteScore: 0)
Middle East African J. of Ophthalmology     Open Access   (Followers: 2, SJR: 0.523, CiteScore: 1)
Middle East J. of Medical Genetics     Open Access  
Muller J. of Medical Sciences and Research     Open Access  
National J. of Maxillofacial Surgery     Open Access   (Followers: 2)
National Medical J. of India     Open Access   (Followers: 1, SJR: 0.188, CiteScore: 0)
Neural Regeneration Research     Open Access   (Followers: 1, SJR: 0.648, CiteScore: 2)
Neurology India     Open Access   (Followers: 1, SJR: 0.413, CiteScore: 1)
New Nigerian J. of Clinical Research     Open Access  
Nigerian J. of Basic and Clinical Sciences     Open Access   (Followers: 1)
Nigerian J. of Cardiology     Open Access   (Followers: 1)
Nigerian J. of Cardiovascular & Thoracic Surgery     Open Access  
Nigerian J. of Clinical Practice     Open Access   (SJR: 0.398, CiteScore: 1)
Nigerian J. of Experimental and Clinical Biosciences     Open Access  
Nigerian J. of General Practice     Open Access  
Nigerian J. of Health Sciences     Open Access  
Nigerian J. of Ophthalmology     Full-text available via subscription   (Followers: 1)
Nigerian J. of Orthopaedics and Trauma     Open Access  
Nigerian J. of Plastic Surgery     Open Access   (Followers: 4)
Nigerian J. of Surgery     Open Access   (Followers: 1)
Nigerian J. of Surgical Research     Open Access  
Nigerian J. of Surgical Sciences     Open Access  
Nigerian Medical J.     Open Access   (Followers: 3)
Nigerian Postgraduate Medical J.     Open Access  
Noise and Health     Open Access   (Followers: 4, SJR: 0.876, CiteScore: 2)
North American J. of Medical Sciences     Open Access   (SJR: 0.627, CiteScore: 2)
Nursing and Midwifery Studies     Open Access   (Followers: 29)
Oman J. of Ophthalmology     Open Access   (Followers: 2, SJR: 0.388, CiteScore: 1)
Oncology J. of India     Open Access  
Paediatric Orthopaedics and Related Sciences     Open Access   (Followers: 3)
Pan Arab J. of Rhinology     Open Access  
Parasitologists United J.     Open Access  
Pediatric Respirology and Critical Care Medicine     Open Access   (Followers: 1)
Perspectives in Clinical Research     Open Access  
Pharmaceutical Methods     Open Access  
Pharmacognosy Magazine     Open Access   (Followers: 2, SJR: 0.519, CiteScore: 2)
Pharmacognosy Research     Open Access   (Followers: 3, SJR: 0.506, CiteScore: 2)
Pharmacognosy Reviews     Open Access   (Followers: 1, SJR: 1.12, CiteScore: 5)
Physiotherapy : The J. of Indian Association of Physiotherapists     Open Access  
Pigment Intl.     Open Access   (Followers: 1)
Port Harcourt Medical J.     Open Access  
Radiation Protection and Environment     Open Access   (Followers: 1)
Ramon Llull J. of Applied Ethics     Open Access   (SJR: 0.101, CiteScore: 0)
Reproductive and Developmental Medicine     Open Access  
Research and Opinion in Anesthesia and Intensive Care     Open Access   (Followers: 2)
Research in Cardiovascular Medicine     Open Access   (SJR: 0.241, CiteScore: 1)
Research in Pharmaceutical Sciences     Open Access   (Followers: 3, SJR: 0.557, CiteScore: 2)
Sahel Medical J.     Open Access  
Saint's Intl. Dental J.     Open Access  
Saudi Critical Care J.     Open Access   (Followers: 12)
Saudi Endodontic J.     Open Access   (Followers: 1)
Saudi J. for Health Sciences     Open Access   (Followers: 1)
Saudi J. of Anaesthesia     Open Access   (Followers: 6, SJR: 0.454, CiteScore: 1)
Saudi J. of Forensic Medicine and Sciences     Open Access  
Saudi J. of Gastroenterology     Open Access   (Followers: 2, SJR: 0.579, CiteScore: 1)
Saudi J. of Kidney Diseases and Transplantation     Open Access   (Followers: 2, SJR: 0.284, CiteScore: 1)
Saudi J. of Laparoscopy     Open Access  
Saudi J. of Medicine and Medical Sciences     Open Access   (Followers: 1)
Saudi J. of Obesity     Open Access   (Followers: 1)
Saudi J. of Oral Sciences     Open Access   (Followers: 1)
Saudi J. of Sports Medicine     Open Access   (Followers: 2)
Saudi Surgical J.     Open Access  

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Journal Cover
Journal of Advanced Pharmaceutical Technology & Research
Journal Prestige (SJR): 0.309
Citation Impact (citeScore): 1
Number of Followers: 3  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2231-4040 - ISSN (Online) 0976-2094
Published by Medknow Publishers Homepage  [427 journals]
  • Pharmaceutical “quality by design” approach

    • Authors: Upendra Nagaich
      Pages: 1 - 1
      Abstract: Upendra Nagaich
      Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):1-1

      Citation: Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):1-1
      PubDate: Wed,17 Jan 2018
      DOI: 10.4103/japtr.JAPTR_343_17
      Issue No: Vol. 9, No. 1 (2018)
       
  • Polymeric micelles as cutaneous drug delivery system in normal skin and
           dermatological disorders

    • Authors: Behzad Sharif Makhmalzade, Fateme Chavoshy
      Pages: 2 - 8
      Abstract: Behzad Sharif Makhmalzade, Fateme Chavoshy
      Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):2-8
      The easy accessibility of skin made dermal application, one of the approaches for local drug therapy. Effectiveness of topical drug application is depended on different parameters such as skin barrier properties, physicochemical properties of drug and vehicle, and interaction between drug and its vehicle with the skin layers. In this review, an overview of skin structure and feature of polymeric micelles as topical nanocarriers is provided. We also summarized the research studies dealing with the application of polymeric micelles for cutaneous delivery. In the past decades, numerous types of nanocarriers have been widely investigated as a novel delivery approach to improve skin penetration and localization of drugs in normal skin and dermatological diseases. Polymeric micelles are one of them, with their specific ability to encapsulate hydrophilic drugs. These carriers can enhance the therapeutic efficacy and minimize the systemic side effects of the drugs. Polymeric micelles could enhance the deposition of drugs in targeted sites of the skin in the normal and dermatological diseases such as psoriasis and acne. Nevertheless, still there is a need to investigate the mechanism of action of these carriers and the fate of polymeric micelles in skin.
      Citation: Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):2-8
      PubDate: Wed,17 Jan 2018
      DOI: 10.4103/japtr.JAPTR_314_17
      Issue No: Vol. 9, No. 1 (2018)
       
  • The off-label use of drugs for parenteral nutrition as a solvent of
           substances slightly soluble in water in pharmacological research

    • Authors: Aleksandr L Urakov, Ilshat G Mustafin, Aleksandr V Samorodov, Felix Kh Kamilov, Ferkat A Khaliullin
      Pages: 9 - 14
      Abstract: Aleksandr L Urakov, Ilshat G Mustafin, Aleksandr V Samorodov, Felix Kh Kamilov, Ferkat A Khaliullin
      Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):9-14
      Because of the problem to evaluate biological activity in water-soluble substances in all phases of preclinical and clinical studies, the research work enabled to develop the original solvent for poorly soluble compounds based on substances for parenteral nutrition. The main aim is to examine the impact of the original solvent based on substances for parenteral nutrition on biological systems exemplified by the hemostatic system, characterized by sensitivity and variability of the effects in response to any impact, and its comparison with the solvents that are conventional in pharmacological research. Experimental work is performed according to the “guidance on preclinical research of new pharmacological substances” in vitro. The findings show that traditional solvents at low dosages affect all the researched indicators of the hemostasis system. The smallest effect in respect of the hemostatic system was characterized by ethanol, and the most apparent antiaggregational effect was registered with dioxane. 10% concentration of original blend of lipids made no effect on hemostasis system. Thus, according to their own findings and experience in application of lipid emulsions as substances of parenteral nutrition, they can be considered to be an adequate solvent in all phases of preclinical and clinical studies of new drugs.
      Citation: Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):9-14
      PubDate: Wed,17 Jan 2018
      DOI: 10.4103/japtr.JAPTR_280_17
      Issue No: Vol. 9, No. 1 (2018)
       
  • The effect of Calendula officinalis versus metronidazole on bacterial
           vaginosis in women: A double-blind randomized controlled trial

    • Authors: Zahra Pazhohideh, Solmaz Mohammadi, Nosrat Bahrami, Faraz Mojab, Parvin Abedi, Elham Maraghi
      Pages: 15 - 19
      Abstract: Zahra Pazhohideh, Solmaz Mohammadi, Nosrat Bahrami, Faraz Mojab, Parvin Abedi, Elham Maraghi
      Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):15-19
      Bacterial vaginosis (BV) is a common disorder among women of reproductive age. This study aimed to compare the effect of a Calendula officinalis extract-based cream and metronidazole on BV among women of reproductive age. In this study, 80 women of reproductive age with BV were randomly assigned to the C. officinalis (n = 40) or metronidazole (n = 40). Diagnosis of BV was confirmed when at least 3 of the 4 Amsel criteria were met (pH >4.5, whitish grey or thin homogeneous discharge, release of a fishy odor on adding 10% KOH, and detection of clue cells on microscopic examination). For each group, either a methanol extract of C. officinalis or metronidazole vaginal cream (5 g) was used for 1 week intravaginally, and all signs and symptoms were assessed 1 week after treatment completion. Before the intervention, the two groups did not differ significantly with regard to vaginal burning, odor, dysuria, and dyspareunia, but itching was significantly more common in the C. officinalis group than in the metronidazole group (22.5% vs. 2.5%, P = 0.01). One week after the intervention, all women in both groups were free of symptoms, including vaginal itching and burning sensation, odor, dysuria, and dyspareunia. None of the women in either group suffered any side effects from C. officinalis or metronidazole. C. officinalis was effective for the treatment of BV in women of reproductive age, without any side effects. This herb could be recommended for women of reproductive age who uncomfortable with the potential side effects of synthetic drugs.
      Citation: Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):15-19
      PubDate: Wed,17 Jan 2018
      DOI: 10.4103/japtr.JAPTR_305_17
      Issue No: Vol. 9, No. 1 (2018)
       
  • Zika virus disease knowledge among the future health-care providers of the
           United Arab Emirates

    • Authors: Syed Arman Rabbani, Farhan Mustafa, Tasneem Shouqair, Itaf Mohamad, Nada Tahsin
      Pages: 20 - 25
      Abstract: Syed Arman Rabbani, Farhan Mustafa, Tasneem Shouqair, Itaf Mohamad, Nada Tahsin
      Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):20-25
      Zika virus (ZIKV) disease has become a major public health concern. Although there are no reported cases of ZIKV disease in the United Arab Emirates (UAE), there is a potential risk of transmission due to large expatriate population and high influx of international travelers. This cross-sectional study was conducted to assess the knowledge of ZIKV disease among the students of a medical and health sciences university in the UAE. Their knowledge of ZIKV disease was assessed using a specially designed, pretested, and validated questionnaire. Of the 500 respondents included in the final analysis, 314 (62.8%) respondents presented with poor knowledge of ZIKV disease. The mean knowledge score of the study population was 10.48 ± 2.48 out of a maximum of 17. Gender, college and year of study, nationality and attendance in lecture/conference/workshop on Zika were significantly associated with the level of knowledge. The males possessed significantly (P = 0.046) better knowledge as compared to the females. Students of medical college had significantly (P = 0.005) better knowledge as compared to students of other colleges. The level of knowledge improved significantly (P = 0.026) as the year of study progressed. There is a need for medical and paramedical students to update their knowledge of ZIKV disease as they are the future health-care providers who will be responsible for creating awareness about such outbreaks and their preventive measures.
      Citation: Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):20-25
      PubDate: Wed,17 Jan 2018
      DOI: 10.4103/japtr.JAPTR_239_17
      Issue No: Vol. 9, No. 1 (2018)
       
  • Quality evaluation of Kaempferia parviflora rhizome with reference to
           5,7-dimethoxyflavone

    • Authors: Yamon Pitakpawasutthi, Chanida Palanuvej, Nijsiri Ruangrungsi
      Pages: 26 - 31
      Abstract: Yamon Pitakpawasutthi, Chanida Palanuvej, Nijsiri Ruangrungsi
      Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):26-31
      Kaempferia parviflora Wall. ex Baker is a medicinal plant found in the upper Northeastern regions of Thailand, which belongs to Zingiberaceae family. The present study aims to investigate the standardization parameters, to analyze chemical constituents of volatile oil by gas chromatography-mass spectrometry, and to determine the content of 5,7-dimethoxyflavone in K. parviflora rhizomes by thin-layer chromatography (TLC)-densitometry compared to TLC image analysis. K. parviflora rhizomes from 15 different sources throughout Thailand were investigated for morphological and pharmacognostic parameters. 5,7-Dimethoxyflavone contents were determined by TLC-densitometry with winCATS software and TLC image analysis with ImageJ software. The mobile phase for TLC development consisted of toluene: chloroform: Acetone: formic acid (5: 4: 1: 0.2). For the Results, the pharmacognostic parameters of K. parviflora rhizome were demonstrated. The loss on drying, total ash, acid-insoluble ash, water content, volatile oil content, ethanol, and water-soluble extractive values were found to be 8.979 ± 0.041, 5.127 ± 0.060, 2.174 ± 0.092, 9.291 ± 0.458, 0.028 ± 0.003, 5.138 ± 0.092, and 8.254 ± 0.191 g/100 g of dry weight, respectively. K. parviflora volatile oil showed the major components of α-copaene, dauca-5, 8-diene, camphene, β-pinene, borneol, and linalool. The 5,7-dimethoxyflavone content of K. parviflora rhizomes determined by TLC-densitometry and TLC image analysis were found to be 2.15 ± 0.64 and 1.96 ± 0.51 g/100 g of dry rhizomes, respectively. The 5,7-dimethoxyflavone contents of both methods were not significantly different (P > 0.05) using paired t-test.
      Citation: Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):26-31
      PubDate: Wed,17 Jan 2018
      DOI: 10.4103/japtr.JAPTR_147_17
      Issue No: Vol. 9, No. 1 (2018)
       
  • Effect of Vitamin E and omega 3 fatty acids in type 2 diabetes mellitus
           patients

    • Authors: Ashwitha Shruti Dass, Sarala Narayana, PN Venkatarathnamma
      Pages: 32 - 36
      Abstract: Ashwitha Shruti Dass, Sarala Narayana, PN Venkatarathnamma
      Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):32-36
      Diabetes mellitus (DM) and its complications have been implicated in hyperglycemia-induced oxidative stress. Antioxidants can improve glycemic control, lipid profile, and cognitive functions. We assessed the effect of Vitamin E and omega 3 fatty acids (OFA) on the above parameters. One hundred patients with type 2 DM receiving metformin 500 mg and glimepiride 1 mg were randomized to receive add-on therapy of Vitamin E 400 mg or OFA once daily for 12 weeks and the third group served as control. Fasting blood sugar (FBS), postprandial blood sugar (PPBS), glycated hemoglobin (HbA1c), body mass index (BMI), waist-hip ratio (WHR), lipid profile, and mini-mental state examination were done at baseline and 12 weeks. Eighty-seven patients completed the study. A significant reduction in FBS, PPBS, and HbA1c was observed in all the three groups at 12 weeks. There was significant reduction in total cholesterol and triglycerides (TG) in patients receiving either of the antioxidants and also significant reduction in low-density lipoprotein in patients receiving OFA at 12 weeks compared to baseline. BMI and WHR were significantly increased in control group. Intergroup analysis showed that in patients receiving Vitamin E and OFA, the reduction of FBS, PPBS, and HbA1c were similar. The patients receiving OFA had significant reduction in TG compared to control. There was no significant effect on cognitive function. Vitamin E and OFA had beneficial effects on lipid profile and anthropometric measurements; however, the glycemic control was similar to the patients in control group.
      Citation: Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):32-36
      PubDate: Wed,17 Jan 2018
      DOI: 10.4103/japtr.JAPTR_309_17
      Issue No: Vol. 9, No. 1 (2018)
       
  • The ethanolic extract of ashitaba stem (Angelica keskei [Miq.] Koidz) as
           future antituberculosis

    • Authors: Sri Agung Fitri Kusuma, Yoppi Iskandar, Mutiara Ayu Dewanti
      Pages: 37 - 41
      Abstract: Sri Agung Fitri Kusuma, Yoppi Iskandar, Mutiara Ayu Dewanti
      Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):37-41
      Considering the easy contagion of tuberculosis (TB) disease spread and the emergence of multidrug-resistant TB, which directly impacts the failure of therapeutic goals and mortality rates increasing, TB disease control remains to be the main concern of continuous health development effort. Therefore, the discovery of new TB drug is needed. This research assessed the new natural anti-TB drug from the ethanolic extract of Angelica keiskei stem obtained from Lombok, Indonesia. The objectives of this study were to evaluate the sensitivity of Mycobacterium tuberculosis (Mtb) H37Rv strain to A. keiskei stem extract and to determine its minimum inhibitory concentration (MIC). The extraction methods of A. keiskei stem were done using a maceration method. In addition to phytochemical screening and water content analysis using standard method, the phytochemical parameters were analyzed by thin-layer chromatography. Ethanolic extract of A. keiskei stem was assayed for their Mtb inhibitory activity using the proportion method. The phytochemical analysis result showed that the secondary metabolites contain in the extract were flavonoid, polyphenol, tannin, monoterpenoid and sesquiterpen, quinon, and saponin. The anti-TB test result showed the active activity of ethanolic extract of A. keiskei against Mtb H37Rv strain with MIC ranging from 6% to 8% w/v. In conclusion, ethanolic extract of A. keiskei is a prospective natural anti-TB for the future.
      Citation: Journal of Advanced Pharmaceutical Technology & Research 2018 9(1):37-41
      PubDate: Wed,17 Jan 2018
      DOI: 10.4103/japtr.JAPTR_283_17
      Issue No: Vol. 9, No. 1 (2018)
       
 
 
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