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Publisher: Medknow Publishers   (Total: 429 journals)

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Showing 1 - 200 of 429 Journals sorted alphabetically
Acta Medica Intl.     Open Access   (SJR: 0.101, h-index: 0)
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advanced Biomedical Research     Open Access  
Advances in Human Biology     Open Access   (Followers: 3)
Advances in Skeletal Muscle Function Assessment     Open Access  
African J. for Infertility and Assisted Conception     Open Access  
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.25, h-index: 1)
African J. of Trauma     Open Access   (Followers: 1)
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Alexandria J. of Pediatrics     Open Access  
Ancient Science of Life     Open Access   (Followers: 5)
Anesthesia : Essays and Researches     Open Access   (Followers: 10)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.258, h-index: 1)
Annals of Bioanthropology     Open Access   (Followers: 4)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.308, h-index: 1)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.434, h-index: 1)
Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery     Open Access  
Annals of Indian Psychiatry     Open Access  
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 7, SJR: 0.352, h-index: 1)
Annals of Saudi Medicine     Open Access   (SJR: 0.238, h-index: 1)
Annals of Thoracic Medicine     Open Access   (Followers: 5, SJR: 0.524, h-index: 1)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 12, SJR: 0.152, h-index: 0)
Annals of Tropical Pathology     Open Access  
Apollo Medicine     Open Access  
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Cardiovascular Imaging     Open Access   (Followers: 1, SJR: 0.187, h-index: 0)
Archives of Intl. Surgery     Open Access   (Followers: 10, SJR: 0.302, h-index: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Medicine and Surgery     Open Access  
Archives of Pharmacy Practice     Open Access   (Followers: 6, SJR: 0.102, h-index: 0)
Archives of Trauma Research     Open Access   (Followers: 3, SJR: 0.37, h-index: 2)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 4)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.856, h-index: 2)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.35, h-index: 1)
Asian Pacific J. of Reproduction     Open Access   (SJR: 0.227, h-index: 1)
Asian Pacific J. of Tropical Biomedicine     Open Access   (Followers: 2, SJR: 0.491, h-index: 2)
Asian Pacific J. of Tropical Medicine     Open Access   (Followers: 1, SJR: 0.561, h-index: 2)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
Biomedical and Biotechnology Research J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Canadian J. of Rural Medicine     Full-text available via subscription   (SJR: 0.202, h-index: 0)
Cancer Translational Medicine     Open Access   (Followers: 2)
Cardiology Plus     Open Access  
Chinese Medical J.     Open Access   (Followers: 10, SJR: 0.52, h-index: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Cancer Investigation J.     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 2)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 10, SJR: 0.811, h-index: 2)
Contemporary Clinical Dentistry     Open Access   (Followers: 4, SJR: 0.353, h-index: 1)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.543, h-index: 1)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.152, h-index: 0)
Dental Research J.     Open Access   (Followers: 11, SJR: 0.416, h-index: 1)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 6, SJR: 0.242, h-index: 0)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1, SJR: 1.799, h-index: 2)
Egyptian J. of Chest Diseases and Tuberculosis     Open Access   (Followers: 3, SJR: 0.155, h-index: 0)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.127, h-index: 0)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Nursing J.     Open Access  
Egyptian Orthopaedic J.     Open Access   (Followers: 2)
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.822, h-index: 2)
Environmental Disease     Open Access   (Followers: 2)
Eurasian J. of Pulmonology     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.749, h-index: 2)
European J. of General Dentistry     Open Access   (Followers: 1, SJR: 0.12, h-index: 0)
European J. of Prosthodontics     Open Access   (Followers: 3)
European J. of Psychology and Educational Studies     Open Access   (Followers: 11, SJR: 0.113, h-index: 0)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.112, h-index: 0)
Genome Integrity     Open Access   (Followers: 3, SJR: 0.153, h-index: 0)
Glioma     Open Access  
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Gynecology and Minimally Invasive Therapy     Open Access   (SJR: 0.311, h-index: 1)
Hamdan Medical J.     Open Access  
Heart and Mind     Open Access  
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
Ibnosina J. of Medicine and Biomedical Sciences     Open Access  
IJS Short Reports     Open Access  
Imam J. of Applied Sciences     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.478, h-index: 1)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (Followers: 1, SJR: 0.361, h-index: 1)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.37, h-index: 1)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.604, h-index: 1)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.266, h-index: 1)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.468, h-index: 1)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 5, SJR: 0.445, h-index: 1)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1, SJR: 0.791, h-index: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4, SJR: 0.568, h-index: 1)
Indian J. of Health Sciences     Open Access   (Followers: 3)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.425, h-index: 1)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.503, h-index: 1)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.656, h-index: 1)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.102, h-index: 0)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.347, h-index: 1)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.23, h-index: 0)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 3, SJR: 0.225, h-index: 1)
Indian J. of Ophthalmology     Open Access   (Followers: 5, SJR: 0.498, h-index: 1)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 8, SJR: 0.392, h-index: 1)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.199, h-index: 0)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.454, h-index: 1)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 2, SJR: 0.276, h-index: 1)
Indian J. of Pharmacology     Open Access   (SJR: 0.412, h-index: 1)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.311, h-index: 0)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.408, h-index: 1)
Indian J. of Psychological Medicine     Open Access   (SJR: 0.368, h-index: 1)
Indian J. of Public Health     Open Access   (Followers: 1)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Respiratory Care     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.119, h-index: 0)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.34, h-index: 0)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Transplantation     Open Access  
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.434, h-index: 1)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Indian Spine J.     Open Access  
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intervention     Open Access   (Followers: 1)
Intl. Archives of Health Sciences     Open Access  
Intl. J. of Abdominal Wall and Hernia Surgery     Open Access  
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Clinicopathological Correlation     Open Access  
Intl. J. of Community Dentistry     Open Access  
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1, SJR: 0.192, h-index: 0)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 3, SJR: 0.142, h-index: 0)
Intl. J. of Growth Factors and Stem Cells in Dentistry     Open Access  
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 6)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.535, h-index: 1)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4, SJR: 0.17, h-index: 0)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 2)
Intl. J. of Orofacial Biology     Open Access  
Intl. J. of Orofacial Research     Open Access  
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.623, h-index: 1)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 5, SJR: 0.653, h-index: 1)
Intl. J. of the Cardiovascular Academy     Open Access   (SJR: 0.105, h-index: 0)
Intl. J. of Trichology     Open Access   (SJR: 0.4, h-index: 1)
Intl. J. of Yoga     Open Access   (Followers: 13)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 5)

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Journal Cover
International Journal of Pharmaceutical Investigation
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2230-973X - ISSN (Online) 2230–9713
Published by Medknow Publishers Homepage  [429 journals]
  • Lipid nanocapsules formulation and cellular activities evaluation of a
           promising anticancer agent: EAPB0503

    • Authors: Adrien Chouchou, Anne Aubert-Pouëssel, Christophe Dorandeu, Zahraa Zghaib, Pierre Cuq, Jean-Marie Devoisselle, Pierre-Antoine Bonnet, Sylvie Bégu, Carine Deleuze-Masquefa
      Pages: 155 - 163
      Abstract: Adrien Chouchou, Anne Aubert-Pouëssel, Christophe Dorandeu, Zahraa Zghaib, Pierre Cuq, Jean-Marie Devoisselle, Pierre-Antoine Bonnet, Sylvie Bégu, Carine Deleuze-Masquefa
      International Journal of Pharmaceutical Investigation 2017 7(4):155-163
      Objective: EAPB0503, lead compound of imiqualines, presented high antitumor activities but also a very low water solubility which was critical for further preclinical studies. To apply to EAPB0503, a robust and safe lipid formulation already used for poor soluble anticancer agents for injectable administration at a concentration higher than 1 mg/mL. Materials and Methods: Physicochemical properties of EAPB0503 were determined to consider an adapted formulation. In a second time, lipid nanocapsules (LNC) formulations based on the phase-inversion process were developed for EAPB0503 encapsulation. Then, EAPB0503 loaded-LNC were tested in vitro on different cell lines and compared to standard EAPB0503 solutions. Results: Optimized EAPB0503 LNC displayed an average size of 111.7 ± 0.9 nm and a low polydispersity index of 0.059 ± 0.002. The obtained loading efficiency was higher than 96% with a drug loading of 1.7 mg/mL. A stability study showed stability during 4 weeks stored at 25°C. In vitro results highlighted similar efficiencies between LNC and standard EAPB0503 solutions prepared in dimethyl sulfoxide. Conclusion: In view of results obtained for loading efficiency and drug loading, the use of a LNC formulation is very interesting to permit the solubilization of a lipophilic drug and to improve its bioavailability. Preliminary tested pharmaceutical formulation applied to EAPB0503 significantly improved its water solubility and will be soon considered for future preclinical in vivo studies.
      Citation: International Journal of Pharmaceutical Investigation 2017 7(4):155-163
      PubDate: Fri,6 Apr 2018
      DOI: 10.4103/jphi.JPHI_53_17
      Issue No: Vol. 7, No. 4 (2018)
       
  • Formulation of cilostazol spherical agglomerates by
           crystallo-co-agglomeration technique and optimization using design of
           experimentation

    • Authors: Sanjeevani Shekhar Deshkar, Govind R Borde, Rupali N Kale, Balasaheb A Waghmare, Asha Biju Thomas
      Pages: 164 - 173
      Abstract: Sanjeevani Shekhar Deshkar, Govind R Borde, Rupali N Kale, Balasaheb A Waghmare, Asha Biju Thomas
      International Journal of Pharmaceutical Investigation 2017 7(4):164-173
      Introduction: Spherical agglomeration is one of the novel techniques for improvement of flow and dissolution properties of drugs. Cilostazol is a biopharmaceutics classification system Class II drug with poor solubility resulting in limited bioavailability. The present study aims at improving the solubility and dissolution of cilostazol by crystallo-co-agglomeration technique.Materials and Methods: Cilostazol agglomerates were prepared using various polymers with varying concentration of hydroxypropyl methylcellulose E 50 (HPMC E50), polyvinyl pyrrolidone K30 (PVP K30), and polyethylene glycol 6000. The influence of polymer concentration on spherical agglomerate formation was studied by 32 factorial design. Cilostazol agglomerates were evaluated for percent yield, mean particle size, drug content, aqueous solubility, and in vitro dissolution and further characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD).Results: The agglomeration process resulted in optimized formulation, F3 with mean agglomerate size of 210.0 ± 0.56 μm, excellent flow properties, approximately 15-fold increase in solubility than pure cilostazol and complete drug release in 60 min. Process yield, agglomerate size, and drug release were affected by amount of PVP K 30 and HPMC E50. The presence of drug microcrystal was confirmed by SEM, whereas FTIR study indicated no chemical change. Increase in drug solubility was attributed to change of crystalline drug to amorphous form that is evident in DSC and XRD.Conclusion: Crystallo-co-agglomeration can be adopted as an important approach for increasing the solubility and dissolution of poorly soluble drug.
      Citation: International Journal of Pharmaceutical Investigation 2017 7(4):164-173
      PubDate: Fri,6 Apr 2018
      DOI: 10.4103/jphi.JPHI_39_17
      Issue No: Vol. 7, No. 4 (2018)
       
  • Aminopropyl groups of the functionalized Mobil Crystalline Material 41 as
           a carrier for controlled diclofenac sodium and piroxicam delivery

    • Authors: Elham Khodaverdi, Mina Ahmadi, Hossein Kamali, Farzin Hadizadeh
      Pages: 174 - 181
      Abstract: Elham Khodaverdi, Mina Ahmadi, Hossein Kamali, Farzin Hadizadeh
      International Journal of Pharmaceutical Investigation 2017 7(4):174-181
      Objective: Synthetic Mobil Crystalline Material 41 (MCM-41) as a mesoporous material and functionalized MCM-41 using aminopropyl groups were studied in order to investigate their ability to encapsulate and to control the release of diclofenac sodium and piroxicam.Materials and Methods: MCM-41 was synthesized through sol–gel procedure and functionalized with aminopropyl groups. The physicochemical properties of MCM-41 were studied through particle size analysis, infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, and carbon–hydrogen–nitrogen analysis. Diclofenac sodium and piroxicam were loaded into the MCM-41 matrix using the filtration and solvent evaporation methods. The drug-loading capacity was determined by ultraviolet, Fourier transform infrared, X-ray diffraction, and Brunauer–Emmett–Teller analysis.Results: According to the results for pure drug release, >57% was released in the 1st h, but when these drugs were loaded into pure Mobil Crystalline Material 41 (MCM-41) and functionalized MCM-41, the release into the simulated gastrointestinal medium was less, continuous, and slower. The release of piroxicam from functionalized MCM-41 was slower than that from MCM-41 in the simulated intestinal medium because of the formation of electrostatic bonds between piroxicam and the aminopropyl groups of the functionalized MCM-41. However, in the case of diclofenac sodium, there was no significant difference between pure MCM-41 and functionalized MCM-41. The difference between piroxicam and diclofenac sodium was due to the high solubility of diclofenac sodium in the intestinal medium (pH 6.8), which caused more rapid release from the matrixes than for piroxicam.Conclusion: Our findings indicate that, after functionalization of MCM-41, it could offer a good means of delivering controlled diclofenac sodium and piroxicam.
      Citation: International Journal of Pharmaceutical Investigation 2017 7(4):174-181
      PubDate: Fri,6 Apr 2018
      DOI: 10.4103/jphi.JPHI_77_17
      Issue No: Vol. 7, No. 4 (2018)
       
  • Drug information center as referral service in a South Indian tertiary
           care hospital

    • Authors: Sapan Kumar Behera, Alphienes Stanley Xavier, Vikneswaran Gunaseelan, Byrappa Kempalalakshmamma Ravindra, Sandhiya Selvarajan, Adithan Chandrasekaran, Steven Aibor Dkhar
      Pages: 182 - 187
      Abstract: Sapan Kumar Behera, Alphienes Stanley Xavier, Vikneswaran Gunaseelan, Byrappa Kempalalakshmamma Ravindra, Sandhiya Selvarajan, Adithan Chandrasekaran, Steven Aibor Dkhar
      International Journal of Pharmaceutical Investigation 2017 7(4):182-187
      Objective: The objective of this study is to assess the various aspects of drug information services (DISs) provided in the DI center of a tertiary care hospital.Materials and Methods: DI queries received from various departments from April 2013 to May 2017 were included in the study. Various aspects such as year- and department-wise distribution, reason for sending the queries, mode of receipt and reply, time taken for reply, number of visit for bedside examination of patients, and number of references given per query were analyzed. All the results are expressed in numbers and percentages.Results: Fifty-five DI queries were received during the study period. Most of the queries were received from Department of Orthopedics (26, 47.27%), followed by Neurology (4, 7.27%). Most common mode of receipt of queries (41, 74.55%) was by Cross-reference form not case record form followed by phone calls (8, 14.55%) and outpatient department (OPD) case sheet (6, 10.9%). CRF with attached opinion was the most common mode of reply (41, 74.55%) followed by phone calls (7, 12.73%), and OPD case sheets (6, 10.9%). The most common reason for sending queries was antimicrobials-related problem (25, 45.46%), followed by the use of anticoagulants (13, 23.63%). Most of the queries were replied within 24 h (31, 56.36%), followed by 48 h (14, 25.45%). Out of 41 CRF received for in-patients, bedside examination was requested in 23 (56.09%) CRF. There was an increasing trend in the number of queries received every year with more queries received during 2016 (23, 41.82%).Conclusions: DIS if utilized properly can be used as a referral service such as other specialties in a tertiary care hospital.
      Citation: International Journal of Pharmaceutical Investigation 2017 7(4):182-187
      PubDate: Fri,6 Apr 2018
      DOI: 10.4103/jphi.JPHI_90_17
      Issue No: Vol. 7, No. 4 (2018)
       
  • Effect of local application of curcumin and ornidazole gel in chronic
           periodontitis patients

    • Authors: PL Ravishankar, Y Pradeep Kumar, EN Anila, Priyankar Chakraborty, Maharshi Malakar, R Mahalakshmi
      Pages: 188 - 192
      Abstract: PL Ravishankar, Y Pradeep Kumar, EN Anila, Priyankar Chakraborty, Maharshi Malakar, R Mahalakshmi
      International Journal of Pharmaceutical Investigation 2017 7(4):188-192
      Objective: The objective of this study is to evaluate the comparative effect of curcumin and ornidazole in treating chronic periodontitis.Materials and Methods: Twenty individuals of both sexes aged between 27 and 53 years diagnosed with chronic periodontitis and having pocket depths >5 mm bilaterally were selected for this study, in a split-mouth design. Examination of plaque index, probing pocket depth, and clinical attachment level was measured for each patient. The patients received a complete prophylaxis including scaling and root planing after which, both test gels were injected into the two experimental sites chosen, that had probing depth (PD) >5 mm and were located in symmetric quadrants. Pocket PD, clinical attachment loss, and plaque index were recorded at days 0 and 30.Results: At 1-month evaluation, curcumin group showed a significant decrease in pocket PD, plaque index, and clinical attachment loss when compared to the ornidazole group.Conclusion: The results show a more favorable outcome with curcumin than ornidazole gel, thus curcumin can be used as an adjunct to nonsurgical periodontal therapy.
      Citation: International Journal of Pharmaceutical Investigation 2017 7(4):188-192
      PubDate: Fri,6 Apr 2018
      DOI: 10.4103/jphi.JPHI_82_17
      Issue No: Vol. 7, No. 4 (2018)
       
  • An assessment of reported adverse drug reactions in a Tertiary Care
           Hospital in South India: A retrospective cross-sectional study

    • Authors: Sandeep Kumar Gupta, K Deva Kumar
      Pages: 193 - 197
      Abstract: Sandeep Kumar Gupta, K Deva Kumar
      International Journal of Pharmaceutical Investigation 2017 7(4):193-197
      Objective: The primary objective of this study was to assess the causality of ADRs using World Health Organization-Uppsala Monitoring Centre (WHO–UMC), Naranjo and Liverpool ADR Causality Assessment Tool (LCAT). Other primary objective was to assess the agreement between the WHO-UMC criterion, Naranjo algorithm and LCAT. The secondary objective was to assess the reported adverse drug reactions in a tertiary care hospital in South India.Materials and Methods: This was a cross-sectional retrospective study. All the ADRs which were reported by the Pharmacovigilance Unit between July 2016 and March 2017 were assessed. Causality assessment was performed by two well-trained independent pharmacologists by applying the three methods–WHO, Naranjo and LCAT. Concurrence between the two algorithms was compared using the Cohen's weighted kappa statistic.Results: Causality assessment of adverse reactions according to Naranjo criteria shows that 81% cases were of probable type, 9.5% cases were possible and 9.5% cases were unlikely. Causality assessment of adverse reactions according to WHO-UMC criteria shows that 85.7% cases were of probable type, 4.8% cases were possible, 4.8% cases were unlikely and 4.8% cases were definite. Causality assessment of adverse reactions according to Liverpool criteria shows that 61.9% cases were of probable type, 4.8% cases were possible and 33.3% cases were definite. Cohen's kappa test shows that negative and poor concurrence was seen between WHO and Naranjo causality comparison (κ = −0.161). Positive but poor concurrence based on kappa values was seen between Liverpool and Naranjo's causality comparison (κ = 0.133). Negative and poor concurrence based on kappa values was seen between WHO and Liverpool causality comparison (κ = −0.161).Conclusion: The most frequent causality category observed by the WHO-UMC criteria, Naranjo as well as the Liverpool algorithm was “Probable.” Full concurrence was not found between any of two scales of causality assessment.
      Citation: International Journal of Pharmaceutical Investigation 2017 7(4):193-197
      PubDate: Fri,6 Apr 2018
      DOI: 10.4103/jphi.JPHI_81_17
      Issue No: Vol. 7, No. 4 (2018)
       
  • Erratum: Development of a binary carrier system consisting polyethylene
           glycol 4000 - ethyl cellulose for ibuprofen solid dispersion

    • Pages: 198 - 198
      Abstract:
      International Journal of Pharmaceutical Investigation 2017 7(4):198-198

      Citation: International Journal of Pharmaceutical Investigation 2017 7(4):198-198
      PubDate: Fri,6 Apr 2018
      DOI: 10.4103/2230-973X.229440
      Issue No: Vol. 7, No. 4 (2018)
       
 
 
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