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Publisher: Medknow Publishers   (Total: 429 journals)

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Showing 1 - 200 of 429 Journals sorted alphabetically
Acta Medica Intl.     Open Access   (SJR: 0.101, CiteScore: 0)
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advanced Biomedical Research     Open Access  
Advances in Human Biology     Open Access   (Followers: 3)
Advances in Skeletal Muscle Function Assessment     Open Access  
African J. for Infertility and Assisted Conception     Open Access  
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.25, CiteScore: 1)
African J. of Trauma     Open Access   (Followers: 1)
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Alexandria J. of Pediatrics     Open Access  
Ancient Science of Life     Open Access   (Followers: 5)
Anesthesia : Essays and Researches     Open Access   (Followers: 10)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.258, CiteScore: 1)
Annals of Bioanthropology     Open Access   (Followers: 4)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.308, CiteScore: 1)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery     Open Access  
Annals of Indian Psychiatry     Open Access  
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 9, SJR: 0.352, CiteScore: 1)
Annals of Saudi Medicine     Open Access   (SJR: 0.238, CiteScore: 1)
Annals of Thoracic Medicine     Open Access   (Followers: 6, SJR: 0.524, CiteScore: 1)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 13, SJR: 0.152, CiteScore: 0)
Annals of Tropical Pathology     Open Access  
Apollo Medicine     Open Access  
APOS Trends in Orthodontics     Open Access  
Arab J. of Interventional Radiology     Open Access  
Archives of Cardiovascular Imaging     Open Access   (Followers: 1, SJR: 0.187, CiteScore: 0)
Archives of Intl. Surgery     Open Access   (Followers: 10, SJR: 0.302, CiteScore: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Medicine and Surgery     Open Access  
Archives of Pharmacy Practice     Open Access   (Followers: 6, SJR: 0.102, CiteScore: 0)
Archives of Trauma Research     Open Access   (Followers: 3, SJR: 0.37, CiteScore: 2)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 4)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.856, CiteScore: 2)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.35, CiteScore: 1)
Asian Pacific J. of Reproduction     Open Access   (SJR: 0.227, CiteScore: 1)
Asian Pacific J. of Tropical Biomedicine     Open Access   (Followers: 2, SJR: 0.491, CiteScore: 2)
Asian Pacific J. of Tropical Medicine     Open Access   (Followers: 1, SJR: 0.561, CiteScore: 2)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
Biomedical and Biotechnology Research J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Canadian J. of Rural Medicine     Full-text available via subscription   (SJR: 0.202, CiteScore: 0)
Cancer Translational Medicine     Open Access   (Followers: 2)
Cardiology Plus     Open Access  
Chinese Medical J.     Open Access   (Followers: 10, SJR: 0.52, CiteScore: 1)
CHRISMED J. of Health and Research     Open Access   (Followers: 2)
Clinical Cancer Investigation J.     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 2)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 10, SJR: 0.811, CiteScore: 2)
Contemporary Clinical Dentistry     Open Access   (Followers: 4, SJR: 0.353, CiteScore: 1)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.543, CiteScore: 1)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.152, CiteScore: 0)
Dental Research J.     Open Access   (Followers: 11, SJR: 0.416, CiteScore: 1)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 6, SJR: 0.242, CiteScore: 0)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1, SJR: 1.799, CiteScore: 2)
Egyptian J. of Chest Diseases and Tuberculosis     Open Access   (Followers: 3, SJR: 0.155, CiteScore: 0)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.127, CiteScore: 0)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Nursing J.     Open Access  
Egyptian Orthopaedic J.     Open Access   (Followers: 2)
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.822, CiteScore: 2)
Environmental Disease     Open Access   (Followers: 3)
Eurasian J. of Pulmonology     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.749, CiteScore: 2)
European J. of General Dentistry     Open Access   (Followers: 1, SJR: 0.12, CiteScore: 0)
European J. of Prosthodontics     Open Access   (Followers: 3)
European J. of Psychology and Educational Studies     Open Access   (Followers: 11, SJR: 0.113, CiteScore: 0)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.112, CiteScore: 0)
Genome Integrity     Open Access   (Followers: 3, SJR: 0.153, CiteScore: 0)
Glioma     Open Access  
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Gynecology and Minimally Invasive Therapy     Open Access   (SJR: 0.311, CiteScore: 1)
Hamdan Medical J.     Open Access  
Heart and Mind     Open Access  
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
Ibnosina J. of Medicine and Biomedical Sciences     Open Access  
IJS Short Reports     Open Access  
Imam J. of Applied Sciences     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.478, CiteScore: 1)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (Followers: 1, SJR: 0.361, CiteScore: 1)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.37, CiteScore: 1)
Indian J. of Critical Care Medicine     Open Access   (Followers: 3, SJR: 0.604, CiteScore: 1)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.266, CiteScore: 1)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.468, CiteScore: 1)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 4, SJR: 0.445, CiteScore: 1)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1, SJR: 0.791, CiteScore: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4, SJR: 0.568, CiteScore: 1)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.425, CiteScore: 1)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.503, CiteScore: 1)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.656, CiteScore: 1)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.102, CiteScore: 0)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.347, CiteScore: 1)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.23, CiteScore: 0)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 3, SJR: 0.225, CiteScore: 1)
Indian J. of Ophthalmology     Open Access   (Followers: 4, SJR: 0.498, CiteScore: 1)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 8, SJR: 0.392, CiteScore: 1)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.199, CiteScore: 0)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.454, CiteScore: 1)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 2, SJR: 0.276, CiteScore: 1)
Indian J. of Pharmacology     Open Access   (SJR: 0.412, CiteScore: 1)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.311, CiteScore: 0)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.408, CiteScore: 1)
Indian J. of Psychological Medicine     Open Access   (SJR: 0.368, CiteScore: 1)
Indian J. of Public Health     Open Access   (Followers: 1)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Respiratory Care     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.119, CiteScore: 0)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.34, CiteScore: 0)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Transplantation     Open Access  
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Indian Spine J.     Open Access  
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intervention     Open Access   (Followers: 1)
Intl. Archives of Health Sciences     Open Access  
Intl. J. of Abdominal Wall and Hernia Surgery     Open Access   (Followers: 1)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Clinicopathological Correlation     Open Access  
Intl. J. of Community Dentistry     Open Access  
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1, SJR: 0.192, CiteScore: 0)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 3, SJR: 0.142, CiteScore: 0)
Intl. J. of Growth Factors and Stem Cells in Dentistry     Open Access  
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 6)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.535, CiteScore: 1)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4, SJR: 0.17, CiteScore: 0)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 2)
Intl. J. of Orofacial Biology     Open Access   (Followers: 1)
Intl. J. of Orofacial Research     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.623, CiteScore: 1)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 5, SJR: 0.653, CiteScore: 1)
Intl. J. of the Cardiovascular Academy     Open Access   (SJR: 0.105, CiteScore: 0)
Intl. J. of Trichology     Open Access   (SJR: 0.4, CiteScore: 1)
Intl. J. of Yoga     Open Access   (Followers: 14)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 5)

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Journal Cover
Indian Journal of Rheumatology
Journal Prestige (SJR): 0.119
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0973-3698 - ISSN (Online) 0973-3701
Published by Medknow Publishers Homepage  [429 journals]
  • From the editor's desk

    • Authors: Vinod Ravindran
      Pages: 79 - 79
      Abstract: Vinod Ravindran
      Indian Journal of Rheumatology 2018 13(2):79-79

      Citation: Indian Journal of Rheumatology 2018 13(2):79-79
      PubDate: Thu,24 May 2018
      DOI: 10.4103/0973-3698.233116
      Issue No: Vol. 13, No. 2 (2018)
       
  • Rheumatology training in India: Pragmatism needed

    • Authors: Durga Prasanna Misra, Vikas Agarwal
      Pages: 80 - 81
      Abstract: Durga Prasanna Misra, Vikas Agarwal
      Indian Journal of Rheumatology 2018 13(2):80-81

      Citation: Indian Journal of Rheumatology 2018 13(2):80-81
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_16_18
      Issue No: Vol. 13, No. 2 (2018)
       
  • Rheumatology training in India and the UK: Time for a unified and bespoke
           approach

    • Authors: Nilesh Nolkha, Kaushik Chaudhuri, Srinivasan Venkatachalam
      Pages: 82 - 83
      Abstract: Nilesh Nolkha, Kaushik Chaudhuri, Srinivasan Venkatachalam
      Indian Journal of Rheumatology 2018 13(2):82-83

      Citation: Indian Journal of Rheumatology 2018 13(2):82-83
      PubDate: Thu,24 May 2018
      DOI: 10.4103/0973-3698.233163
      Issue No: Vol. 13, No. 2 (2018)
       
  • A prospective, randomized, double-blind, comparative clinical study of
           efficacy and safety of a biosimilar adalimumab with innovator product in
           patients with active rheumatoid arthritis on a stable dose of methotrexate
           

    • Authors: Prasad Apsangikar, Sunil Chaudhry, Manoj Naik, Shashank Deoghare, Jamila Joseph
      Pages: 84 - 89
      Abstract: Prasad Apsangikar, Sunil Chaudhry, Manoj Naik, Shashank Deoghare, Jamila Joseph
      Indian Journal of Rheumatology 2018 13(2):84-89
      Objective: The objective of this study was to compare efficacy, safety, and immunogenicity between the biosimilar adalimumab (AdaliRel) and the reference innovator product in moderate-to-severe rheumatoid arthritis (RA) patients on stable dose of methotrexate (MTX).Methods: Patients with moderate-to-severe active RA (n = 106) on a stable dose of MTX were randomized to biosimilar adalimumab (AdaliRel) (study arm) or reference innovator adalimumab (reference arm) 40 mg every 2 weeks. The primary endpoint was proportion of patients who achieve ACR20 response at week 16. The secondary endpoint was proportion of patients who achieve ACR50, ACR70, absolute values, and changes from baseline in the disease activity score 28 joint (DAS28), health assessment questionnaire-disability index (HAQ-DI), C-reactive protein (CRP), and rheumatoid factor (RF) at week 16 and week 24. Safety was assessed through adverse events (AEs) and laboratory evaluations up to week 34. Antidrug antibodies were assessed to determine immunogenicity.Results: Out of 106 randomized, 104 individuals were dosed in the study (one subject from each arm was dropped due to consent withdrawal). The number of patients achieving ACR20 response at week 16 was 90.48% in study arm and 90% in the reference arm. The number of patients ACR70 response at week 16 was 13.1% in the study arm and 15% in the reference arm. There was no statistically significant difference between the two treatment arms in terms of number of responders (P > 0.05). No difference also was observed in DAS28, HAQ-DI scores, RF, and CRP changes from baseline. There were no clinically meaningful differences in AEs. Immunogenicity profile at week 16 did not indicate any clinically significant concerns.Conclusion: Biosimilar adalimumab (AdaliRel) and the reference product showed comparable efficacy and safety in RA patients who were on stable dose of MTX.
      Citation: Indian Journal of Rheumatology 2018 13(2):84-89
      PubDate: Thu,24 May 2018
      DOI: 10.4103/0973-3698.233164
      Issue No: Vol. 13, No. 2 (2018)
       
  • Circulating levels of osteoprotegerin and sRANKL and the effect of
           methotrexate in patients with rheumatoid arthritis

    • Authors: Aadhaar Dhooria, Narendhiran Pandurangan, Karthik Vinay Mahesh, Suchet Sachdev, Aman Sharma, Shefali Sharma, Nidhi Gupta, Varun Dhir
      Pages: 90 - 94
      Abstract: Aadhaar Dhooria, Narendhiran Pandurangan, Karthik Vinay Mahesh, Suchet Sachdev, Aman Sharma, Shefali Sharma, Nidhi Gupta, Varun Dhir
      Indian Journal of Rheumatology 2018 13(2):90-94
      Background: Receptor activator of nuclear factor κβ ligand (RANKL) and osteoprotegerin (OPG) are pivotal molecules involved in osteoclast activation and resorption. In RA, their alterations mediated through inflammatory cytokines are responsible for erosions and systemic bone loss. This study planned to look at the effect of methotrexate on circulating levels of OPG and RANKL in RA.Methods: Methotrexate-naive patients with active rheumatoid arthritis (RA) between 18 and 65 years of age were included. Controls were derived from voluntary healthy blood donors after written consent. All patients were started on methotrexate at 15 mg/week, increased by 5 mg every 4 weeks till maximum tolerated dose or 25 mg/week whichever was lower. Circulating plasma levels of OPG and RANKL were measured for cases (at baseline and 24 weeks) and controls (at baseline).Results: Fifty-one consecutive patients with RA and 57 controls were recruited. Circulating OPG (mean ± standard deviation) levels were higher in RA patients as compared to controls, 2879.6 ± 1037.9 and 2214.1 ± 705.3 pg/ml, respectively (P < 0.001). RANKL levels did not differ significantly between cases and controls. After treatment, circulating OPG levels fell significantly, from 2879.6 ± 1037.9 to 2059.8 ± 532.1 pg/ml (P < 0.001), however, no significant change in circulating RANKL levels. No difference was found in OPG and RANKL levels between patients with erosive and nonerosive disease.Conclusions: OPG levels are higher in RA patients and normalize in response to treatment with methotrexate. The initial higher levels of OPG may represent a compensatory mechanism to osteoclast activation; they normalize on reduction of disease activity.
      Citation: Indian Journal of Rheumatology 2018 13(2):90-94
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_125_17
      Issue No: Vol. 13, No. 2 (2018)
       
  • Anti-neutrophil cytoplasmic autoantibodies associated vasculitis –
           Clinical profile and outcomes

    • Authors: Kavya Devi Nunna, Phani Kumar Devarasetti, Rajendra Vara Prasad Irlapati, Liza Rajasekhar
      Pages: 95 - 100
      Abstract: Kavya Devi Nunna, Phani Kumar Devarasetti, Rajendra Vara Prasad Irlapati, Liza Rajasekhar
      Indian Journal of Rheumatology 2018 13(2):95-100
      Background: Studies on antineutrophil cytoplasmic autoantibodies-associated vasculitis (AAV) from India are scarce. The aim of the present study was to characterize the profile of AAV and experience with rituximab in ocular granulomatous with polyangiitis (GPA) in our cohort.Methods: Clinical, laboratory, and treatment details of AAV from January 2010 to May 2017 were noted. Continuous variables were reported as mean and standard deviation (SD). In GPA, clinical variables between survivors and nonsurvivors were compared using independent sample t-test and Fisher's exact test. Cox regression analysis was done to estimate the hazard ratios. Our cohort of GPA was compared with other large single-center cohorts from India, USA, Germany, and France.Results: Thirty-one patients were diagnosed to have AAV. Seventeen were females. GPA was most common phenotype (23/31). Mean (SD) age at onset was 39.8 (15.7) years. Median (IQ) time to diagnosis was 6 (22) months. The most common manifestations in GPA were ocular (n = 20) and lower respiratory tract (n = 13). Mean (SD) Birmingham Vasculitis Activity Score (BVAS) at disease onset was 9.4 (6.9). Pulse methylprednisolone with cyclophosphamide was used as induction regime followed by maintenance with azathioprine. Rituximab was given to four patients with refractory GPA. Six patients succumbed to illness. Remission was achieved in 19/25 survivors. Mean (SD) BVAS at disease onset was significantly higher in nonsurvivors (17.6 ± 10.2) compared to survivors (9.4 ± 4.9) (P = 0.018). Higher proportion of renal involvement was seen in nonsurvivors (P = 0.03). There was three-fold increased mortality with renal and lung involvement. In addition, the risk of death increases by 1.13 fold with each point increase in BVAS score.Conclusion: Ocular involvement was higher in our GPA cohort. Baseline BVAS, renal, and lung involvement predicts poor prognosis in GPA. Sustained remission with rituximab was seen in all patients with refractory ocular disease.
      Citation: Indian Journal of Rheumatology 2018 13(2):95-100
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_80_17
      Issue No: Vol. 13, No. 2 (2018)
       
  • Poor quality of life in indian ankylosing spondylitis patients

    • Authors: Latika Gupta, Sakir Ahmed, Gautam Dhar Choudhury, Durga Prasanna Misra, Vikas Agarwal
      Pages: 101 - 106
      Abstract: Latika Gupta, Sakir Ahmed, Gautam Dhar Choudhury, Durga Prasanna Misra, Vikas Agarwal
      Indian Journal of Rheumatology 2018 13(2):101-106
      Background: Ankylosing Spondylitis (AS) is a chronic inflammatory disease that leads to significant disability. We sought to study the impact of the disease activity and functional impairment on QoL in Indian patients with AS. Methods: World Health Organization- Quality of Life-BREF (WHOQoL-BREF) questionnaire was used to measure quality of life (QoL) in 99 adults with AS (modified Rome criteria), 72 healthy individuals, and 20 rheumatoid arthritis patients. Apart from demographic variable such as age, gender, clinical manifestations, and treatment received, disease activity parameters such as duration of early morning stiffness, BASDAI, swollen and tender joint count, Erythrocyte Sedimentation Rate (ESR) and C Reactive Protein (CRP) were also recorded. Presence of damage was assessed using spinal radiographs. All values are in median (IQR).Results: Out of the 99 patients, 5 were females and 5 had juvenile onset AS. Median age was 32 (26-42) years and median disease duration was 6 (1.25-10) years. Forty-three had peripheral arthritis and 18 had enthesitis. Syndesmophytes were present on spinal radiographs in 54 cases. BASDAI correlated negatively with the physical, psychological and environmental domains (P < 0.05), while BASFI and BASMI did not. In all 4 domains of WHO-BREF, scores for AS were significantly less as compared to healthy controls [P < 0.0001] or even to rheumatoid arthritis [P < 0.01].Conclusion: Indian AS patients have poorer quality of life than patients with rheumatoid arthritis and healthy individuals, possibly due to poor control of disease activity.
      Citation: Indian Journal of Rheumatology 2018 13(2):101-106
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_108_17
      Issue No: Vol. 13, No. 2 (2018)
       
  • Serum Interleukin-6, Interleukin-17A, and transforming growth factor beta
           are raised in systemic sclerosis with interstitial lung disease

    • Authors: Anupam Wakhlu, Rasmi Ranjan Sahoo, Jyoti Ranjan Parida, Mohit K Rai, Durga P Misra, Vinita Agrawal, Vikas Agarwal
      Pages: 107 - 112
      Abstract: Anupam Wakhlu, Rasmi Ranjan Sahoo, Jyoti Ranjan Parida, Mohit K Rai, Durga P Misra, Vinita Agrawal, Vikas Agarwal
      Indian Journal of Rheumatology 2018 13(2):107-112
      Background: Dysregulation in cytokines like interleukin-6 (IL-6), interleukin-17A (IL-17A) and transforming growth factor-beta (TGF β1) has been pathogenically implicated in systemic sclerosis (SSc). The present study aimed to assess their serum levels in patients with SSc and correlate with clinical manifestations.Methods: This cross-sectional, observational study included 93 patients fulfilling the 2013 revised ACR/EULAR SSc classification criteria and 33 age-and sex-matched healthy controls. Antinuclear antibody (ANA), extractable nuclear antigen (ENA) profile, chest radiograph, pulmonary function tests and electrocardiography were done. HRCT of thorax and echocardiography were done wherever indicated. Modified Rodnan skin score (MRSS) was calculated. Serum IL-6, IL-17A and TGF β1 levels were assayed using ELISA kit and compared among disease subtypes and clinical parameters. Spearman coefficient was used to test correlation between continuous variables. P value of <0.05 was considered significant. Results: The mean age of patients was 37.8+10.3 years (Female:Male: 30:1) with median duration of disease of 3 years. Serum IL-6, IL-17A and TGF β1 levels were significantly higher in patients as compared to controls (IL-6: 19.4±11 vs 6.7±3.9 pg/ml (P < 0.0001); IL-17A: 39.1±14.8 vs 16.4±2.1 pg/ml (P < 0.0001); TGF β1: 862.2±443 vs 377.2±208.8 pg/ml (P < 0.0001). Higher levels of these cytokines were also observed in patients of diffuse cutaneous SSc, those with lung fibrosis and anti-topoisomerase positivity.Conclusion: Serum IL-6, IL-17A and TGF β1 levels were significantly higher in SSc patients and higher levels were associated with ILD and skin fibrosis.
      Citation: Indian Journal of Rheumatology 2018 13(2):107-112
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_106_17
      Issue No: Vol. 13, No. 2 (2018)
       
  • Rheumatology training in India compared to the United Kingdom

    • Authors: Parthajit Das, Arumugan Moorthy, Balebail Dharmanand
      Pages: 113 - 116
      Abstract: Parthajit Das, Arumugan Moorthy, Balebail Dharmanand
      Indian Journal of Rheumatology 2018 13(2):113-116
      Background: Rheumatology is an emerging specialty in India, and there is a huge demand for trained rheumatologist to satiate the overwhelming musculoskeletal disease burden in India. Rheumatology training in the UK is structured and comprehensive. This study was aimed to explore the strengths and weaknesses in the rheumatology training in India as compared to the UK.Methods: This was an observational semiqualitative study. An online questionnaire was circulated electronically to rheumatology trainees across the UK and India. The questionnaire was designed to explore the curriculum content, training and research opportunities, training assessment methodologies, and employability in two countries.Results: A total of 77 respondents participated in this study, 52% (40/77) were from the UK and 48% (37/77) from India. We noted heterogeneity in the structure and delivery of training with multiple incongruous training curricula being prevalent in India. Institutional academic training supervision was comparable in both countries. UK trainees received comparatively more structured supervision for procedural skills. Indian trainees were proficient with laboratory-based rheumatological and immunological tests. Professional research and academic programs were incorporated in UK training. Mandatory training for generic skills was lacking in India. Specialty exit examination was mandatory in both countries. Employment opportunities were better perceived in the Indian subcontinent. Conclusions: In this study comparing rheumatology training between the UK and India,a lack of structured and coherent national curriculum in India was noted. Harmonisation of rheumatology training in India is essential to be at par with the well-established postgraduate rheumatology training curriculum in developed countries.
      Citation: Indian Journal of Rheumatology 2018 13(2):113-116
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_78_17
      Issue No: Vol. 13, No. 2 (2018)
       
  • Effectiveness of a 1-day workshop on scientific writing conducted by the
           Indian journal of rheumatology

    • Authors: Mohit Goyal, Durga Prasanna Misra, Samir Rajadhyaksha, Yogesh Preet Singh, Neha Goyal, Vinod Ravindran
      Pages: 117 - 120
      Abstract: Mohit Goyal, Durga Prasanna Misra, Samir Rajadhyaksha, Yogesh Preet Singh, Neha Goyal, Vinod Ravindran
      Indian Journal of Rheumatology 2018 13(2):117-120
      Background: Writing a scientific manuscript is an important skill to acquire for junior doctors considering the mandatory requirement of research publications during post-graduate training and for career advancement in India. Methods: We conducted a one-day workshop on scientific writing and publication at Udaipur in November 2017, comprising both didactic lectures as well as hands-on evaluation of a dummy manuscript, and evaluated structured questionnaires filled pre- and post-workshop. Results: There were 120 attendees, most of whom were junior doctors with little or no prior experience in writing a scientific paper. A significant baseline knowledge deficit regarding the principles and processes of scientific writing (ranging from 20.9% to 77.3% participants for the different questions asked) could be identified before the workshop. This knowledge deficit was significantly improved in most areas as assessed after the workshop. We identified the need to discuss predatory publishing in greater detail in subsequent workshops, as 20.8% of respondents after the workshop professed that they might consider publishing in a predatory journal. As expressed in participant feedback, longer, more-specialized or advanced level workshops on scientific writing in the future could also consider including more details on appropriate statistical presentation and pictorial representation of data as well as longer time spent on hands-on exercises. Conclusion: There remains a need to conduct more scientific writing workshops by national societies and journals all over the country.
      Citation: Indian Journal of Rheumatology 2018 13(2):117-120
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_36_18
      Issue No: Vol. 13, No. 2 (2018)
       
  • Vascular cytoprotection, autoimmune disease, and premature atherosclerosis

    • Authors: Justin C Mason
      Pages: 121 - 128
      Abstract: Justin C Mason
      Indian Journal of Rheumatology 2018 13(2):121-128
      A healthy vascular endothelium is critical to health, and interference with endothelial homeostasis disrupts hemostasis, regulation of vascular tone and blood pressure, leukocyte trafficking, angiogenesis and tissue repair. Endothelial injury and apoptosis leads to endothelial dysfunction, which is closely associated with increased generation of reactive oxygen species, reduced endothelial nitric oxide (NO) synthase, increased consumption, and impaired synthesis of NO. Systemic inflammatory diseases including rheumatoid arthritis and systemic lupus erythematosus are associated with endothelial dysfunction, increased aortic stiffness, and accelerated atherogenesis. Premature cardiovascular disease is well-recognized feature of many rheumatic diseases. The cell and molecular mechanisms related to this remain poorly understood. Specific diseases display individual and common attributes that likely influence cardiovascular risk. A key challenge is the development of the means by which those at highest risk can be identified. Likewise, the ability of current therapies to mitigate risk and the identification of novel vasculoprotective therapies represent important areas of research focus. Similarly, close liaison between rheumatologists and cardiologists is essential to minimize the cardiovascular impact on patients and to ensure that patients with rheumatic disease and coexistent coronary heart disease receive appropriate therapy. Identification of safe therapeutic approaches that combine the targeted immunosuppression required, along with comprehensive vascular protection to control the primary disease and prevent secondary complications over the longer term, remains the ultimate challenge.
      Citation: Indian Journal of Rheumatology 2018 13(2):121-128
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_6_18
      Issue No: Vol. 13, No. 2 (2018)
       
  • Palmar fasciitis and polyarthritis as a paraneoplastic syndrome

    • Authors: Prasanta Padhan, Swati Mishra
      Pages: 129 - 130
      Abstract: Prasanta Padhan, Swati Mishra
      Indian Journal of Rheumatology 2018 13(2):129-130

      Citation: Indian Journal of Rheumatology 2018 13(2):129-130
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_138_17
      Issue No: Vol. 13, No. 2 (2018)
       
  • Ulcerative colitis and systemic sclerosis

    • Authors: Mayank Jain
      Pages: 131 - 132
      Abstract: Mayank Jain
      Indian Journal of Rheumatology 2018 13(2):131-132

      Citation: Indian Journal of Rheumatology 2018 13(2):131-132
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_141_17
      Issue No: Vol. 13, No. 2 (2018)
       
  • Long segment extensive transverse myelitis in a patient of ankylosing
           spondylitis

    • Authors: Vijay Sardana, Sunil Kumar Sharma, Dilip Maheshwari, Bharat Bhushan
      Pages: 133 - 134
      Abstract: Vijay Sardana, Sunil Kumar Sharma, Dilip Maheshwari, Bharat Bhushan
      Indian Journal of Rheumatology 2018 13(2):133-134

      Citation: Indian Journal of Rheumatology 2018 13(2):133-134
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_118_17
      Issue No: Vol. 13, No. 2 (2018)
       
  • Calcinosis cutis in connective tissue diseases

    • Authors: Gianfranco Vitiello, Boaz Palterer, Paola Parronchi, Daniele Cammelli
      Pages: 135 - 136
      Abstract: Gianfranco Vitiello, Boaz Palterer, Paola Parronchi, Daniele Cammelli
      Indian Journal of Rheumatology 2018 13(2):135-136

      Citation: Indian Journal of Rheumatology 2018 13(2):135-136
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_21_18
      Issue No: Vol. 13, No. 2 (2018)
       
  • Supplementing pyridoxine and cobalamin in addition to folic acid in
           patients on methotrexate therapy

    • Authors: Anand Narayan Malaviya, Shubha Bhalla, Shallu Verma, Roopa Rawat
      Pages: 137 - 138
      Abstract: Anand Narayan Malaviya, Shubha Bhalla, Shallu Verma, Roopa Rawat
      Indian Journal of Rheumatology 2018 13(2):137-138

      Citation: Indian Journal of Rheumatology 2018 13(2):137-138
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_29_18
      Issue No: Vol. 13, No. 2 (2018)
       
  • Aseptic meningitis as the first manifestation in a young male with
           systemic lupus erythematosus

    • Authors: Shamsudeen Moideen, NA Uvais
      Pages: 139 - 140
      Abstract: Shamsudeen Moideen, NA Uvais
      Indian Journal of Rheumatology 2018 13(2):139-140

      Citation: Indian Journal of Rheumatology 2018 13(2):139-140
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_143_17
      Issue No: Vol. 13, No. 2 (2018)
       
  • Tolosa&#8211;Hunt syndrome in a patient of lupus

    • Authors: Jeet Patel, Lalit Duggal, Neeraj Jain, Bhandari Gurbir Singh, Amal Basnet, Anjal Bisht
      Pages: 141 - 142
      Abstract: Jeet Patel, Lalit Duggal, Neeraj Jain, Bhandari Gurbir Singh, Amal Basnet, Anjal Bisht
      Indian Journal of Rheumatology 2018 13(2):141-142

      Citation: Indian Journal of Rheumatology 2018 13(2):141-142
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_2_18
      Issue No: Vol. 13, No. 2 (2018)
       
  • Comments on: Vitamin D and autoimmune diseases

    • Authors: Ankur Dalal
      Pages: 143 - 144
      Abstract: Ankur Dalal
      Indian Journal of Rheumatology 2018 13(2):143-144

      Citation: Indian Journal of Rheumatology 2018 13(2):143-144
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_144_17
      Issue No: Vol. 13, No. 2 (2018)
       
  • Handbook on research methodology

    • Authors: Anupam Wakhlu, Durga Prasanna Misra
      Pages: 145 - 145
      Abstract: Anupam Wakhlu, Durga Prasanna Misra
      Indian Journal of Rheumatology 2018 13(2):145-145

      Citation: Indian Journal of Rheumatology 2018 13(2):145-145
      PubDate: Thu,24 May 2018
      DOI: 10.4103/injr.injr_73_18
      Issue No: Vol. 13, No. 2 (2018)
       
 
 
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