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Publisher: Medknow Publishers   (Total: 355 journals)

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Showing 1 - 200 of 355 Journals sorted alphabetically
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advances in Human Biology     Open Access   (Followers: 1)
African J. for Infertility and Assisted Conception     Open Access  
African J. of Business Ethics     Open Access   (Followers: 6)
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.269, h-index: 10)
African J. of Trauma     Open Access  
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 6)
Anesthesia : Essays and Researches     Open Access   (Followers: 8)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.331, h-index: 15)
Annals of Bioanthropology     Open Access   (Followers: 3)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.408, h-index: 15)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.308, h-index: 14)
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 7, SJR: 0.441, h-index: 10)
Annals of Saudi Medicine     Open Access   (SJR: 0.24, h-index: 29)
Annals of Thoracic Medicine     Open Access   (Followers: 4, SJR: 0.388, h-index: 19)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 15, SJR: 0.148, h-index: 5)
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Intl. Surgery     Open Access   (Followers: 9)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Pharmacy Practice     Open Access   (Followers: 6)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 3)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.879, h-index: 49)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 2, SJR: 0.362, h-index: 10)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Cancer Translational Medicine     Open Access   (Followers: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 1)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access   (Followers: 1)
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 12, SJR: 0.82, h-index: 12)
Contemporary Clinical Dentistry     Open Access   (Followers: 4)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.339, h-index: 19)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.131, h-index: 4)
Dental Research J.     Open Access   (Followers: 9)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 5, SJR: 0.205, h-index: 22)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access  
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.121, h-index: 3)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Orthopaedic J.     Open Access  
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.473, h-index: 8)
Environmental Disease     Open Access   (Followers: 2)
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.496, h-index: 11)
European J. of General Dentistry     Open Access   (Followers: 1)
European J. of Prosthodontics     Open Access   (Followers: 2)
European J. of Psychology and Educational Studies     Open Access   (Followers: 8)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.107, h-index: 5)
Genome Integrity     Open Access   (Followers: 4, SJR: 1.227, h-index: 12)
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
IJS Short Reports     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 8, SJR: 0.302, h-index: 13)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (SJR: 0.318, h-index: 26)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.618, h-index: 16)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.307, h-index: 16)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.243, h-index: 24)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.448, h-index: 16)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 3, SJR: 0.563, h-index: 29)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.292, h-index: 9)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.53, h-index: 34)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.716, h-index: 60)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.207, h-index: 31)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.233, h-index: 12)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.213, h-index: 5)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 4, SJR: 0.203, h-index: 13)
Indian J. of Ophthalmology     Open Access   (Followers: 5, SJR: 0.536, h-index: 34)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 9, SJR: 0.393, h-index: 15)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.218, h-index: 5)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.35, h-index: 12)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 1, SJR: 0.285, h-index: 22)
Indian J. of Pharmacology     Open Access   (SJR: 0.347, h-index: 44)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.303, h-index: 13)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.496, h-index: 15)
Indian J. of Psychological Medicine     Open Access   (Followers: 1, SJR: 0.344, h-index: 9)
Indian J. of Public Health     Open Access   (Followers: 1, SJR: 0.444, h-index: 17)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4, SJR: 0.253, h-index: 14)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.169, h-index: 7)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.313, h-index: 9)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.366, h-index: 16)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 4, SJR: 0.229, h-index: 13)
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 7)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.239, h-index: 4)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.523, h-index: 15)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 7, SJR: 0.611, h-index: 9)
Intl. J. of Trichology     Open Access   (SJR: 0.37, h-index: 10)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 3)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 4, SJR: 0.427, h-index: 15)
J. of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 8, SJR: 0.416, h-index: 14)
J. of Applied Hematology     Open Access  
J. of Association of Chest Physicians     Open Access   (Followers: 2)
J. of Basic and Clinical Reproductive Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Therapeutics     Open Access   (Followers: 4, SJR: 0.359, h-index: 21)
J. of Carcinogenesis     Open Access   (Followers: 1, SJR: 1.152, h-index: 26)
J. of Cardiothoracic Trauma     Open Access  
J. of Cardiovascular Disease Research     Open Access   (Followers: 3, SJR: 0.351, h-index: 13)
J. of Cardiovascular Echography     Open Access   (SJR: 0.134, h-index: 2)
J. of Cleft Lip Palate and Craniofacial Anomalies     Open Access   (Followers: 2)
J. of Clinical and Preventive Cardiology     Open Access   (Followers: 1)
J. of Clinical Imaging Science     Open Access   (Followers: 1, SJR: 0.277, h-index: 8)
J. of Clinical Neonatology     Open Access   (Followers: 1)
J. of Clinical Ophthalmology and Research     Open Access   (Followers: 2)
J. of Clinical Sciences     Open Access  
J. of Conservative Dentistry     Open Access   (Followers: 4, SJR: 0.532, h-index: 10)
J. of Craniovertebral Junction and Spine     Open Access   (Followers: 4, SJR: 0.199, h-index: 9)
J. of Current Medical Research and Practice     Open Access  
J. of Current Research in Scientific Medicine     Open Access  
J. of Cutaneous and Aesthetic Surgery     Open Access   (Followers: 1)
J. of Cytology     Open Access   (Followers: 1, SJR: 0.274, h-index: 9)
J. of Dental and Allied Sciences     Open Access   (Followers: 1)
J. of Dental Implants     Open Access   (Followers: 7)
J. of Dental Lasers     Open Access   (Followers: 2)
J. of Dental Research and Review     Open Access   (Followers: 1)
J. of Digestive Endoscopy     Open Access   (Followers: 3)
J. of Dr. NTR University of Health Sciences     Open Access  
J. of Earth, Environment and Health Sciences     Open Access   (Followers: 1)
J. of Education and Ethics in Dentistry     Open Access   (Followers: 5)
J. of Education and Health Promotion     Open Access   (Followers: 5)
J. of Emergencies, Trauma and Shock     Open Access   (Followers: 9, SJR: 0.353, h-index: 14)
J. of Engineering and Technology     Open Access   (Followers: 6)
J. of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
J. of Family and Community Medicine     Open Access   (Followers: 2)
J. of Family Medicine and Primary Care     Open Access   (Followers: 11)

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Journal Cover Indian Journal of Medical and Paediatric Oncology
  [SJR: 0.292]   [H-I: 9]   [0 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 0971-5851 - ISSN (Online) 0975-2129
   Published by Medknow Publishers Homepage  [355 journals]
  • A study of clinical profile of primary extranodal lymphomas in a tertiary
           care institute in South India

    • Authors: Ananth Pai, Thiruvengadasamy Kannan, RG Balambika, Vindhya Vasini
      Pages: 251 - 255
      Abstract: Ananth Pai, Thiruvengadasamy Kannan, RG Balambika, Vindhya Vasini
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):251-255
      Context: Primary extranodal lymphoma (pENL) refers to group of disorders arising from tissues other than lymph nodes. The incidence of pENL is increasing and is probably due to better diagnostic immunophenotyping and imaging modalities. Hence, this study was undertaken to ascertain the incidence, distribution, and histological subtypes of extranodal non-Hodgkin lymphoma (NHL) in a tertiary care institute in South India. Subjects and Methods: This was a retrospective study of patients diagnosed to have histologically proven NHL. The demographic and clinical features, laboratory parameters, imaging findings, histopathology, and immunophenotyping were documented. The lymphomas were grouped as extranodal and nodal. The data were tabulated in a Microsoft Excel sheet, and descriptive analysis was done. Results: Primary extranodal NHLs constituted 35.96% (41/114) of all NHLs. The B symptoms were less common in pENL compared to nodal NHL. Gastrointestinal tract (GIT) constituted the most common extranodal site (19/41, 46.34%), and diffuse large B-cell lymphoma (DLBCL) was the most common histological subtype. Majority (40/41, 97%) of the patients with pENL were immunocompetent. 31/41 (75%) patients were in Stage I–II compared to 58/73 (79.4%) patients in Stage III–IV in nodal NHL. Conclusions: Primary extranodal NHL constituted about one-third of patients diagnosed to have NHL at our center with the GIT being the most common site of presentation and DLBCL being the most common histology. A strong suspicion of NHL at an extranodal site with appropriate pathological and immunophenotyping evidence is needed to establish the diagnosis of a pENL.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):251-255
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_82_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Adrenal mass: Unusual presentation and outcome

    • Authors: Raghu Sampally Ramareddy, Anand Alladi
      Pages: 256 - 260
      Abstract: Raghu Sampally Ramareddy, Anand Alladi
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):256-260
      Aim: Adrenal mass may be functioning or nonfunctioning with varied clinical presentations. This study aimed to report the nature and management of uncommon adrenal mass and to review literature. Materials and Methods: This was an retrospective observational analysis of children with uncommon adrenal mass admitted during 2009–2015. Clinical features, investigations, and management of patients were analyzed. Results: Among six, two each were adolescent and neonate, and one each was young infant and prenatal. Clinical presentation was variable; hypertensive retinopathy,[1] virilization[1] and bleeding diathesis,[1] antenatal suprarenal mass,[1] prenatal adrenal angiolipoma,[1] and spontaneous resolution of Stage III suprarenal mass.[1] Ultrasound and contrast-enhanced computed tomography revealed well-defined, heterogeneous adrenal mass. Size varied from 2 to 15 cm. Urinary metanephrine and serum testosterone were raised in adolescent hypertensive boys and virilized girls, respectively. Laparoscopy-assisted adrenalectomy was done in two and other four were managed conservatively. Histopathology of tumor revealed pheochromocytoma and borderline oncocytoma. Spontaneous resolution of adrenal mass had varied etiology; adrenal hemorrhagic lesion,[1] simple cyst,[1] neuroblastoma.[1] Follow-up varied from 3 months to 2 years. All patients were asymptomatic on last follow-up. Conclusion: Close clinical follow-up, contrast-enhanced tomography, and limited/specific endocrine work-up have definite role in the management of uncommon adrenal mass.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):256-260
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_33_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Clinico-radiological and pathological characteristics of inflammatory
           myofibroblastic tumors in children: A retrospective study

    • Authors: Mohamad Hussain Mir, Waseem Dar, Sheikh AejazAziz, Gul Mohamad, Burhan Wani
      Pages: 261 - 265
      Abstract: Mohamad Hussain Mir, Waseem Dar, Sheikh AejazAziz, Gul Mohamad, Burhan Wani
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):261-265
      Purpose: Inflammatory myofibroblastic tumors (IMTs) are rare, benign lesions most often seen in the lung of young adults but can occur in children, in various sites. They mimic, clinically and radiologically, malignant tumors – especially sarcomas and lymphomas. The aim was to review the clinical, radiological, and pathological data of children with a diagnosis of IMT referred to our department. Materials and Methods: This retrospective study was conducted at the Department of Medical and Paediatric Oncology, Regional Cancer Centre, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India from January 2014 to December 2015. Results: Among 288 pediatric tumors registered during the study, 5 (1.73%) had the diagnosis of IMTs. The main symptoms were abdominal distension and pain in 60% (three cases), breathlessness and cough in 20% (one case), and right axillary area swelling in 20% (one case). In three patients, complete surgical excision was done, whereas another patient with retroperitoneal mass had the residual disease and received chemotherapy followed by complete second surgery. In the case of mediastinal IMT, surgery was followed by local radiotherapy. At present, four patients are disease-free and one patient with mediastinal IMT has the residual progressive disease. Conclusion: On presentation, IMT can constitute a formidable challenge, from diagnosis through to treatment.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):261-265
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_178_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Multiplex approach in classification, diagnosis, and prognostication in
           acute myeloid leukemia: An experience from tertiary cancer center in South
           India

    • Authors: Rachna Khera, Faiq Ahmed, Manasi Chetan Mundada, Sandhya G Devi, Sudha S Murthy, Nambaru Lavanya, Senthil J Rajappa, Krishna Mohan Mallavarapu, A Santa
      Pages: 266 - 272
      Abstract: Rachna Khera, Faiq Ahmed, Manasi Chetan Mundada, Sandhya G Devi, Sudha S Murthy, Nambaru Lavanya, Senthil J Rajappa, Krishna Mohan Mallavarapu, A Santa
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):266-272
      Introduction: Acute myeloid leukemia (AML) is a heterogeneous group of disorders classified as per FAB subtypes and more recently by WHO by underlying genetic abnormalities. Aims and Objectives: This study aims to analyze the morphology, immunophenotype, cytogenetic and molecular abnormalities in around 200 patients of AML diagnosed over a period of 7 years at our institute and to determine relative frequency of various subtypes (based on FAB and WHO classification). An attempt to characterize the associations between hematological parameters, immunophenotype and these subtypes was also made. Materials and Methods: All cases diagnosed as AML on morphology, cytochemistry and/or immunophenotyping and tested for recurrent genetic abnormalities during period of Jan 2008-July 2014 were included in the study. Results: Age of presentation was younger in our AML patients as compared to western literature. Amongst FAB and WHO subtypes, M2 and t (15;17) PML-RARA were the most common groups respectively. As expected, CD33, CD13, were the most commonly expressed markers followed by HLA-DR, CD117, CD34 and CD14. Aberrant expression was seen in 62(41.6%) cases, most common was CD7 (15.4%), followed by CD56 (14.8%), CD19 (6.7%) and CD2 (4.7%). Significant associations between immunophenotypic markers and FAB subtypes as well as WHO subtypes were established. Conclusion: This is a hospital based study, giving a detailed account of frequencies of AML subtypes, hematological parameters and immunophenotypic markers in AML patients at our institute. Being a large and one of its kind study to establish significant associations between various haematological and immunophenotypic parameters with respective AML subtypes and genetic abnormalities, it might prove to be very useful in Indian setup where facilities for cytogenetic analysis are not available in many laboratories.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):266-272
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_89_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Evaluation of micronucleus in exfoliated buccal epithelial cells using
           liquid-based cytology preparation in petrol station workers

    • Authors: P Arul, Smitha Shetty, Suresh Masilamani, C Akshatha, BJ Naveen Kumar
      Pages: 273 - 276
      Abstract: P Arul, Smitha Shetty, Suresh Masilamani, C Akshatha, BJ Naveen Kumar
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):273-276
      Background: Liquid-based cytology (LBC) can be used for the evaluation of micronucleus (MN) in exfoliated buccal epithelial cells of populations occupationally exposed to potentially carcinogenic agents. Aim: This study was undertaken to evaluate the frequency of MN of exfoliated buccal epithelial cells using LBC preparation in petrol station workers. Materials and Methods: Fifty petrol station workers (cases) and fifty hospital administrative staffs (controls) were recruited and evaluated for MN by May-Grunwald Giemsa, Hematoxylin and Eosin, and Papanicolaou stains using LBC preparation. Statistical analysis was performed with Student's t-test, and P < 0.05 was considered statistically significant. Results: Regardless of staining method used, the mean frequency of MN for cases was significantly higher than that of controls (P < 0.001). Conclusion: The present study concluded that petrol station workers are under risk of significant cytogenetic damage. The MN in exfoliated buccal epithelial cells found to be a useful biomarker of occupational exposure to genotoxic chemicals. LBC can be used for sample preparation to evaluate the frequency of MN in those who are occupationally exposed to potentially carcinogenic agents in view of overall improvement on sample preservation and visualization of cell morphology.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):273-276
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_26_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Sociodemographic factors and late-stage diagnosis of breast cancer in
           India: A hospital-based study

    • Authors: Jignasa Amrutlal Sathwara, Ganesh Balasubramaniam, Saurabh C Bobdey, Aanchal Jain
      Pages: 277 - 281
      Abstract: Jignasa Amrutlal Sathwara, Ganesh Balasubramaniam, Saurabh C Bobdey, Aanchal Jain
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):277-281
      Context: Breast cancer (BC) is one of the major causes of cancer mortality in India. Late-stage diagnosis of BC is associated with poor survival. Identification of factors affecting late presentation of the disease could be an effective step to reduce BC mortality. Aims: To study the association of sociodemographic factors with BC stage at diagnosis. Settings and Design: The study is a retrospective analysis from the case records from a single institution. Subjects and Methods: Data for the year 2008 was collected from the hospital records. A total of 1210 cases were included for the analysis. Sociodemographic factors included were age, place of residence, religion, marital status, level of education, and occupation. Other study variables were family history, presence of comorbidity, and stage at diagnosis. Statistical Analysis: Association between sociodemographic factors by stage at diagnosis was tested using Chi-square statistics, with odds ratios (ORs) estimated through logistic regression modeling. Results: In the study cohort, 46% patients had reported at early stages and 54% at advanced stages. All factors were evaluated for being predictors of disease stage at presentation using univariate and multivariate logistic regression model. Women from urban background were less likely to present with advanced stage disease (OR = 0.64; 95% confidence interval [CI]: 0.49–0.84) as compared to rural women. Similarly, illiterate women were also more likely to present with advanced-stage disease (OR = 1.55; 95% CI: 1.16–2.09). Conclusions: This data clearly indicate that the patients of rural background and of low education status are more likely than their respective counterparts to have an advanced stage of BC diagnosis. Our results may be considered the keys to determining how stage variation may be related to patients and community characteristics and where limited resources need to be invested to ensure early diagnosis of BC.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):277-281
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_15_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Effectiveness of three prognostic scoring systems in predicting the
           response and outcome in pediatric chronic myeloid leukemia chronic phase
           on frontline imatinib

    • Authors: Ranga Raman Ganta, Srividya Nasaka, Vijay Gandhi Linga, Sadashivudu Gundeti, Lakshmi Srinivas Maddali, Raghunadha Rao Digumarti
      Pages: 282 - 286
      Abstract: Ranga Raman Ganta, Srividya Nasaka, Vijay Gandhi Linga, Sadashivudu Gundeti, Lakshmi Srinivas Maddali, Raghunadha Rao Digumarti
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):282-286
      Introduction: The Sokal and Hasford (Euro) scores were developed in the chemotherapy and interferon eras and are widely used as prognostic indicators in patients with chronic myeloid leukemia (CML). Recently, European Treatment and Outcome Study (EUTOS) scoring system was introduced. Data on risk stratification in pediatric CML population was lacking due to its rarity (<3%). Objective: To study the effectiveness in predicting the response and outcome with three prognostic scores in pediatric CML-chronic phase patients on front line Imatinib. Materials and Methods: We retrospectively analyzed the hospital records of newly diagnosed CML CP patients (aged ≤18 years) from 2006 to 2010 for their risk score, cytogenetic response at 18 months and event free survival (EFS) at the end of 4 years. Events include loss of hematological response, loss of cytological response, progression to accelerated/blast phase (AP/BC). All received free Imatinib under Gleevac international patient assistance program. Results: Data of 106 children was analyzed with median age of 13.5 (ranged 5-18 years) and male preponderance (M:F = 1.14:1). The distribution of children was 63%, 32% and 5% in Sokal low, intermediate and high risk respectively, 50%, 43% and 5% in Hasford/Euro low, intermediate and high risk respectively, 71% and 29% in EUTOS low and high risk respectively. The overall cumulative complete hematological response at the end of 3 month was 94%, and complete cytogenetic response at 12 months was 75%. The CCyR at 18 month was seen in 90%,74% and 83% among Sokal low, intermediate and high risk groups respectively, 83%, 86% and 83% among Hasford/Euro low, intermediate and high risk groups respectively, 84% and 86% EUTOS low and high risk groups respectively. The EFS at the end of 48 months was seen in 87%,79% and 83% among Sokal low, intermediate and high risk groups respectively, 83%, 86% and 83% among Hasford/Euro low, intermediate and high risk groups respectively, 86% and 80% EUTOS low and high risk groups respectively. Conclusion: None of the scoring systems predicted the response and outcome effectively in children with CML CP on front line Imatinib.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):282-286
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_104_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Neurolymphomatosis: A surreal presentation of lymphoma

    • Authors: Shikha Khandelwal, Suvinay Saxena, Disha J Hansalia
      Pages: 287 - 290
      Abstract: Shikha Khandelwal, Suvinay Saxena, Disha J Hansalia
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):287-290
      Background: Neurolymphomatosis is a neurologic complication poorly recognized by neurologists and oncologists and presents usually several months after successful treatment of systemic lymphoma. Other disorders that must be differentiated from these entities include peripheral-nerve or nerve root compression and paraneoplastic neuropathy. Aim: To describe the unusual occurrence of neurolymphomatosis in a patient of B-cell lymphoma. Method: Diagnosis was made by demonstration of enhancement of nerve roots on Magnetic Resonance Imaging of the brachial, lumbosacral plexus, peripheral nerves or by increased hyper-metabolic activity along the course of affected nerves on fluorodeoxyglucose positron emission tomography (FDG-PET). Results and Conclusion: MRI and PET-CT are imaging modalities of choice for evaluation of patients with lymphoma and suspected neural involvement. Treatment of neurolymphomatosis consists of focal radiotherapy and high-dose methotrexate therapy.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):287-290
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_151_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Sociodemographic and clinical profile of cervical cancer patients visiting
           in a tertiary care hospital in India

    • Authors: Aanchal Jain, Balasubramaniam Ganesh, Saurabh C Bobdey, Jignasa A Sathwara, Sushma Saoba
      Pages: 291 - 295
      Abstract: Aanchal Jain, Balasubramaniam Ganesh, Saurabh C Bobdey, Jignasa A Sathwara, Sushma Saoba
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):291-295
      Context: Cancer of the cervix is the most common genital tract malignancy in the female and is a major public health problem in the developing countries. Study of the sociodemographic and clinical profile of patients is the first step in planning control measures and treatment facilities. Aims: The aims of the study were to determine the sociodemographic and clinical profile of cervical cancer patients and study their association with other tumor-related factors. Settings and Design: This is a record-based retrospective study from a single institution. Subjects and Methods: The data on sociodemographic and clinical factors of 765 cervical cancer patients visited and treated at tertiary care cancer hospital in Mumbai in 1 year period were analyzed. Statistical Analysis: Data were analyzed using descriptive statistics. Kruskal–Wallis and Chi-square test were used to assess relationship between variables. Results: The median age of the cohort was 54 years and interquartile range was 16 years. Nearly 53.6% of patients were illiterate. About 88.10% of patient's had squamous cell carcinoma. Only 13% of cases had early stage disease and 77% of patient's had not taken any treatment before coming to the hospital. Of the total, about 26% patients also had concomitant comorbidities, of which hypertension was found to be the leading comorbid condition. Stage of disease was found to be significantly (P < 0.05) associated with age and educational status. Conclusion: This study highlights certain important baseline characteristics of cervical cancer patients. This basic information on profile of patients can help plan and optimum utilization of hospital services, especially in resource-poor countries like India.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):291-295
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_20_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Evaluation of intraoperative cytological smears for diagnosis of brain
           tumors with special reference to immunohistochemistry

    • Authors: Saurav Sarkar, Moumita Sengupta, Chhanda Datta, Uttara Chatterjee, Samarendra Nath Ghosh
      Pages: 296 - 301
      Abstract: Saurav Sarkar, Moumita Sengupta, Chhanda Datta, Uttara Chatterjee, Samarendra Nath Ghosh
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):296-301
      Context: Brain tumors are heterogeneous group of benign and malignant tumors of glial, meningeal, neuronal, embryonal, and lymphoid origin. Rapid intraoperative diagnosis of the nature of the tumor helps the surgeon to plan the extent of surgery and modify it accordingly. Aims: (1) To establish the validity and reliability of squash cytology in the intraoperative diagnosis of brain tumors. (2) To correlate with histopathological report and immunohistochemistry (IHC) profile. Settings and Design: Prospective, observational study. Subjects and Methods: prospective, observational study was conducted in the Department of Pathology in collaboration with the Department of Neurosurgery of a tertiary care hospital. One hundred and seven patients with symptomatic or radiologically detected brain tumors were included in the study. Intraoperative squash smears were stained with hematoxylin and eosin and rapid papanicolaou stain. Cytological diagnosis was recorded and communicated to the surgeon. Cytological findings were corroborated with histological findings subsequently. GFAP, Ki-67, and ER-PR IHC were used as additional markers. Statistical Analysis Used: Software used in statistical analysis of our study was MedCalc version 11.6 (Mariakerke, Belgium: MedCalc Software 2011). Results: A total of 107 cases were included in the study. Meningioma was the most common lesion. Overall sensitivity in our study to diagnose benign and malignant tumors was 94.7% and the specificity is 97.6% with positive and negative predictive value of 94.7% and 97.6%, respectively. Diagnostic accuracy was highest in pituitary adenoma. Conclusions: The combination of meticulous evaluation of clinical, radiological, and cytological findings helps in accurate and rapid diagnosis of brain tumors.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):296-301
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_28_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Radiofrequency ablation of osteoid osteoma in common and technically
           challenging locations in pediatric population

    • Authors: Shaileshkumar Garge, Shyamkumar Nidugala Keshava, Vinu Moses, George Koshy, Munawwar Ahmed, Suraj Mammen, Vrisha Madhuri
      Pages: 302 - 305
      Abstract: Shaileshkumar Garge, Shyamkumar Nidugala Keshava, Vinu Moses, George Koshy, Munawwar Ahmed, Suraj Mammen, Vrisha Madhuri
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):302-305
      Context: Percutaneous radiofrequency ablation (RFA) of osteoid osteoma has a high technical and clinical success rate. However, there is limited data on its use in the pediatric population, especially in technically challenging locations. Objective: The objective of this study was to assess the safety and efficacy of CT-guided percutaneous RFA of osteoid osteoma in pediatric population. Subjects and Methods: From June 2009 to May 2014, thirty patients with osteoid osteoma were treated with CT-guided RFA in common (25 cases) and technically challenging (five cases: four near articular surface and one in sacrum) locations. Therapy was performed under general anesthesia with a three-array expandable RF probe for 6 min at 90°C and power of 60–100 W. The patients were discharged next day under instruction. The treatment success was evaluated in terms of pain relief before and after (1 day, 1 month, and 6 months) treatment. Results: Technical success was achieved in all patients (100%). Primary clinical success was 96.66% (29 of total 30 patients) despite the pediatric population and atypical location. One patient had persistent pain after 1 month duration and were treated successfully with a second procedure (secondary success rate was 100%). One patient had immediate complication of weakness of right hand and fingers extension. No delayed complications were observed. Conclusions: CT-guided RFA is relatively safe and highly effective for treatment of osteoid osteoma in pediatric population, even in technically difficult locations. Advance in Knowledge: Our study showed that if technical success is 100% and if strict desired temperature (90°C) can be maintained for desired time (6 min) using controlled power (wattage) delivery (60–100 W), then high clinical success can be achieved even in pediatric population similar to adult population.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):302-305
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_61_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Status of serum and salivary ascorbic acid in oral potentially malignant
           disorders and oral cancer

    • Authors: Supriya Bhat, Subhas Gogineni Babu, Saidath K Bhat, Renita Lorina Castelino, Kumuda Rao, Medhini Madi
      Pages: 306 - 310
      Abstract: Supriya Bhat, Subhas Gogineni Babu, Saidath K Bhat, Renita Lorina Castelino, Kumuda Rao, Medhini Madi
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):306-310
      Background and Aims: The aim of this study was to estimate the detoxification status of serum and saliva by assessing the serum and salivary Vitamin C in oral potentially malignant disorders and oral cancer. Subjects and Methods: A total of 90 subjects, 30 subjects with oral potentially malignant disorders, 30 subjects with oral cancer, and 30 healthy subjects (controls) were included in the study. Serum and saliva were collected and levels of Vitamin C were assessed. Data obtained was analyzed using ANOVA test for the comparison between the groups. Post hoc Tukey's analysis was used for the comparison of the two study groups to the control group. Correlation between the groups was done using Pearson's correlation coefficient test. Results: The mean serum and salivary Vitamin C levels were decreased significantly in potentially malignant disorders and oral cancer when compared to healthy subjects. Conclusions: As significant reduction of Vitamin C is seen in saliva, it can be stated that saliva can be used as a reliable, noninvasive biomarker in diagnosis and management of potentially malignant disorders and oral cancer.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):306-310
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_67_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Poor risk advanced renal cell carcinoma: Outcomes from a registry in a
           tertiary cancer center

    • Authors: Anant Ramaswamy, Amit Joshi, Vanita Noronha, Vijay Patil, Arvind Sahu, Deepan R Manickam, Rushabh Kothari, Nilesh Sable, Archi Agrawal, Santosh Menon, Kumar Prabhash
      Pages: 311 - 315
      Abstract: Anant Ramaswamy, Amit Joshi, Vanita Noronha, Vijay Patil, Arvind Sahu, Deepan R Manickam, Rushabh Kothari, Nilesh Sable, Archi Agrawal, Santosh Menon, Kumar Prabhash
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):311-315
      Background: Poor-risk advanced Renal cell carcinoma (RCC) are an under-evaluated and difficult to treat subset of patients with poor prognosis. While Temsirolimus is the approved first line therapy for this category, Tyrosine kinase inhibitors (TKIs) are also commonly uses as initial treatment. We present an analysis of poor-risk advanced RCC treated in our institute. Materials and Methods: Patients diagnosed as poor-risk (as per Heng criteria) advanced RCC from June 2008 to December 2015 were analysed for baseline demographics, treatment received, toxicity (primarily Grade 3 and Grade 4), response rates (RR) and survival. Results: 60 patients (43 males, 17 females) with a median age of 53 years were included for final analysis. Median ECOG PS was 1, clear cell was the predominant histology (63.3%), and 46.7% of patients had greater than 2 sites of metastases. Sorafenib, Sunitinib, Temsirolimus and Pazopanib were used to treat 43.3%, 36.7%, 8.3% and 6.7% of patients respectively, while 3 patients were offered upfront best supportive care. Common adverse events included skin rash (31.5%), HFS (Grade 2 and 3 - 30.8%), mucositis (26.3%), hypertension (24.5%), and dyslipidaemias (22.8%). 41 patients were available for response - overall response rate observed was 15%, while clinical benefit rate was 50%. Median progression free survival was 5.78 months (4.67-6.89) and median overall survival (OS) was 10.05 months (7.31-12.79). Conclusion: A majority of poor-risk metastatic RCC patients in our study were treated with TKIs and the survival outcomes appear to suggest that this strategy is a feasible alternative to Temsirolimus in the Indian setting.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):311-315
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_154_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Clinicopathological features and treatment outcomes in Ewing's sarcoma
           

    • Authors: Asmaa Nazeer, Alaa Kandil, Omar Zahra, Maher Soliman
      Pages: 316 - 320
      Abstract: Asmaa Nazeer, Alaa Kandil, Omar Zahra, Maher Soliman
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):316-320
      Background: Ewing's sarcoma (ES) is an aggressive tumor, which is usually associated with micrometastases in the circulation. Thus, systemic chemotherapy in addition to local control modality is essential to improve outcomes. The aim of this study was to evaluate clinicopathological features and treatment outcomes in patients with ES. Materials and Methods: Medical files of 74 patients with nonmetastatic ES treated at our centers between 2004 and 2014 were retrospectively evaluated. The clinicopathological parameters were extracted and statistically correlated with event-free survival (EFS) and overall survival (OS). Results: The median age of patients was 13 years. The median follow-up duration was 63.8 months. About two-thirds (58.1%) of patients were male. Pain (74.3%) was the most common presenting symptom. Extremities (48.6%) were the frequently affected sites. Thirty-two patients (43.2%) presented by tumors larger than 8 cm. All patients were treated with chemotherapy. Local therapies were surgery and/or radiotherapy. The 5-year EFS and OS were 44% and 57%, respectively. On multivariate analysis, EFS and OS were significantly associated with age, tumor site, and tumor size. Conclusions: Despite limited resources in a developing country, the survival rates of ES are comparable to that in developed countries, and prognostic factors are age, tumor site, and tumor size.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):316-320
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_107_17
      Issue No: Vol. 38, No. 3 (2017)
       
  • Assessment of angiogenesis in children with acute lymphoblastic leukemia
           based on serum vascular endothelial growth factor assay

    • Authors: Agnieszka Mizia-Malarz, Grazyna Sobol-Milejska
      Pages: 321 - 325
      Abstract: Agnieszka Mizia-Malarz, Grazyna Sobol-Milejska
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):321-325
      Introduction: Vascular endothelial growth factor A (VEGFA) is a key proangiogenic cytokine. The role of angiogenesis in acute lymphoblastic leukemia (ALL) is still unclear. The purpose of the study was to assess angiogenesis in children with ALL based on serum VEGFA level determined at diagnosis and at remission with further participant subdivision into different risk groups. Materials and Methods: Forty children, aged 3–12 years (mean age: 8 years) with newly diagnosed ALL, were enrolled in the study. The control group (Group C) was twenty healthy children. According to the risk assessment, they were classified into a standard-risk group, an intermediate-risk group (IRG), or a high-risk group (HRG). Results: The median serum VEGFA levels at diagnosis were significantly higher in IRG and HRG as compared to Group C. The VEGFA levels at remission were significantly higher in all study groups, as compared to Group C. The differences in median values of serum VEGFA levels between the study groups both at diagnosis and at remission were not statistically significant. Conclusions: The angiogenesis in ALL seems to be intensified at diagnosis as a result of neoplasmatic bone marrow rebuilding and at remission as its intensive recovering.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):321-325
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_109_17
      Issue No: Vol. 38, No. 3 (2017)
       
  • Physiogenomics in etiopathogenesis of cholangiocarcinoma

    • Authors: Beuy Joob, Viroj Wiwanitkit
      Pages: 326 - 327
      Abstract: Beuy Joob, Viroj Wiwanitkit
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):326-327
      Objective: Cholangiocarcinoma is a serious malignancy that is very common in the tropical countries. It is a kind of deadly primary hepatobiliary tumor. There is a wide spectrum of tumors with varying differentiation and malignancy grades. Although it has been known for a long time inmmedicine, there is no clear cut that this deadly cancer is genetic disorder or not. A systemic approach on the pathophysiology and genomics can provide useful information and help better understand the pathogenesis of cholangiocarcinoma. Methods: In this work, a standard bioinformatics physiological genomics analysis of cholangiocarcinoma was performed. Result: According to this work, there is no identified physiogenomics relationship for the cholangiocarcinoma. Conclusion: This might imply that the cholangiocarcinoma is directly due to environmental insult. It implies that there should be no specific gene that might contribute to the increased risk in the etiopathogenesis of cholangiocarcinoma.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):326-327
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_111_17
      Issue No: Vol. 38, No. 3 (2017)
       
  • The role of mutation testing in patients with chronic myeloid leukemia in
           chronic phase after imatinib failure and their outcomes after treatment
           modification: Single-institutional experience over 13 years

    • Authors: Puligundla Krishna Chaitanya, Karnam Ashok Kumar, Bala Stalin, Gundeti Sadashivudu, Maddali Lakshmi Srinivas
      Pages: 328 - 333
      Abstract: Puligundla Krishna Chaitanya, Karnam Ashok Kumar, Bala Stalin, Gundeti Sadashivudu, Maddali Lakshmi Srinivas
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):328-333
      Introduction: BCR-ABL1 kinase domain mutations represent the most frequent mechanism of resistance to tyrosine kinase inhibitor (TKI) therapy, being detected in 40%–50% of imatinib-resistant patients with chronic myeloid leukemia in chronic phase (CML-CP). Over 100 BCR-ABL1 single-point mutations have been reported in patients with imatinib-resistant CML. There were few studies reported from India on BCR-ABL kinase mutations in imatinib failure patients. We present our data on imatinib resistance mutation analysis (IRMA) and use of imatinib dose hike and 2nd-generation TKI at our institute. Materials and Methods: All patients with a diagnosis of CML in a university hospital from June 2003 to July 2016 and who were tested for IRMA in view of imatinib failure, those in CP, and age <18 years were included in the study. Results: A total of 2110 cases of CML reviewed and 269 cases of CML with imatinib failure were analyzed. The male to female ratio was 1.7:1. The median age at presentation was 36 years (range: 18–66 years). Among these, 26% were primary failures and 74% were secondary failures. The treatment was modified either as imatinib dose hike or nilotinib/dasatinib. Molecular response at 12 months was achieved in 25.7% in imatinib dose hike, 46.6% in nilotinib, and 53.8% in dasatinib arms. The 4-year overall survival in mutation detected group was 37.5% and in nonmutated group was 87.7%. Conclusion: Imatinib-resistant mutations were more common in the cases with secondary failure though not statistically significant. T315I mutation was the common mutation found in the study. Imatinib dose hike to the failure cases resulted in optimal hematological response rates.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):328-333
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_115_17
      Issue No: Vol. 38, No. 3 (2017)
       
  • A study on utilization and evaluation of antiemetics in
           chemotherapy-induced nausea and vomiting

    • Authors: Gayathri Baburaj, Ansha Mariya Abraham, Lija George, Vijith Shetty, Rovin M Thempalangad, KS Rajesh, KC Bharath Raj
      Pages: 334 - 339
      Abstract: Gayathri Baburaj, Ansha Mariya Abraham, Lija George, Vijith Shetty, Rovin M Thempalangad, KS Rajesh, KC Bharath Raj
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):334-339
      Purpose: Chemotherapy-induced nausea and vomiting (CINV) are the major adverse effects of cancer chemotherapy. The objectives of this study are to evaluate the utilization of antiemetics in CINV and to assess the emetogenicity of chemotherapy and to investigate the incidence of acute and delayed CINV. Methods: A prospective observational study was carried out in patients undergoing chemotherapy. A suitable data collection form was designed to collect data regarding patient's demographics, cancer type, chemotherapy regimen, antiemetic prescribed, and incidence of CINV according to the standard methods utilizing morrow assessment of nausea and emesis form. Results: Among 200 patients enrolled in the study, with age range of 18–83 (52 ± 11.65; mean ± standard deviation) of both sexes (44% of male and 56% of female), 38.5% of patients received highly emetogenic chemotherapy and 46.5% received moderate emetogenic chemotherapy. Among the patients, 88% received 5HT3-RA in combination with corticosteroid (99%) and NK1-RA (40.5%). Despite the administration of antiemetic, the incidence of acute and delayed nausea after chemotherapy treatment was reported by 54% and 15.5%, respectively. The comparable figures for acute and delayed vomiting were 36.5% and 14.5%. Conclusion: The incidence of CINV among the patients was relatively high and it indicates that more attention is needed for the treatment of both acute and delayed CINV. It also gives an idea for implementation of more efficient antiemesis guideline in the clinical practice.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):334-339
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_116_17
      Issue No: Vol. 38, No. 3 (2017)
       
  • An investigation of Bayes algorithm and neural networks for identifying
           the breast cancer

    • Authors: E Udayakumar, S Santhi, P Vetrivelan
      Pages: 340 - 344
      Abstract: E Udayakumar, S Santhi, P Vetrivelan
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):340-344
      Context: Breast cancer is a biggest threat to women. X-ray mammography is the most effective method for early detection and screening of breast cancer. It is a tough challenge for the radiologist in reading mammography since it does not provide consistent result every time. Aim: To improve the primary sign of this disease, computer-aided diagnosis schemes have been developed. Using monitor, digital images of mammography are displayed and they can be lightened or darkened before they are printed on the film. Time factor is important to identify the abnormality in body such as breast cancer and lung cancer. Hence, to detect the tissues and treatment stages, image-processing techniques are improved in several medical areas. In this project, using low-level preprocessing techniques and image segmentation, the breast cancer detection is done. Methods: With the help of Bayes algorithm and neural networks (NNs), the type of the mammogram and stages is identified. For segmentation process, region-growing algorithm is used, which helps to find the affected portion, i.e., region of interest. Gray-level co-occurrence matrix (GLCM) and texture feature are used for feature extraction. Results: Bayes algorithm is used for probability of identification, whereas NNs is used to reduce the probability level from 0–1000 to 0–1 in case of classification.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):340-344
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_127_17
      Issue No: Vol. 38, No. 3 (2017)
       
  • Analytical study on the efficacy of neoadjuvant chemotherapy using a
           combination of methotrexate, bleomycin, and cisplatin in the management of
           advanced squamous cell carcinoma of the buccal mucosa

    • Authors: Santosh Manohar Kumar, Srabani Biswas, Shreya Sarkar, Syam Sundar Mandal, Jaydip Biswas
      Pages: 345 - 348
      Abstract: Santosh Manohar Kumar, Srabani Biswas, Shreya Sarkar, Syam Sundar Mandal, Jaydip Biswas
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):345-348
      Context: Cancers of the buccal mucosa (CaBM) predominate in India with late- stage diagnosis and poor survival, necessitating optimal management. Aim: Our study aimed at testing the efficacy of combination neoadjuvant chemotherapy (NACT) using cisplatin (CIS), bleomycin (BL) and methotrexate (MTX) for reducing tumour volume prior to surgery. Methodology: Patients with advanced CaBM (stage III, IV, n = 100) were administered 6 rounds of NACT with CIS, BL and MTX. Responses, toxicity and 6-month follow-up was monitored statistically to determine persistence of response. Results: A significant number of patients showed objective response as either complete or partial tumour regression with subjective response as reduced trismus, pain, salivation and foul odour. Moreover, there was mild associated toxicity and tumour regression continued in most patients even after 6-month follow-up. Conclusion: Our study indicates that NACT with CIS, BL and MTX offers a good therapeutic alternative in terms of significant objective and subjective responses, low toxicity, affordable costs and persistent responses.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):345-348
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_123_17
      Issue No: Vol. 38, No. 3 (2017)
       
  • Round cell tumors: Classification and immunohistochemistry

    • Authors: Shweta Sharma, R Kamala, Divya Nair, T Raju Ragavendra, Swapnil Mhatre, Robin Sabharwal, Basanta Kumar Choudhury, Vivek Rana
      Pages: 349 - 353
      Abstract: Shweta Sharma, R Kamala, Divya Nair, T Raju Ragavendra, Swapnil Mhatre, Robin Sabharwal, Basanta Kumar Choudhury, Vivek Rana
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):349-353
      Round cell tumors as the name suggest are comprised round cells with increased nuclear-cytoplasmic ratio. This group of tumor includes entities such as peripheral neuroectodermal tumor, rhabdomyosarcoma, synovial sarcoma, non-Hodgkin's lymphoma, neuroblastoma, hepatoblastoma, Wilms' tumor, and desmoplastic small round cell tumor. These round cells tumors are characterized by typical histological pattern, immunohistochemical, and electron microscopic features that can help in differential diagnosis. The present article describes the classification and explains the histopathology and immunohistochemistry of some important round cell tumors.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):349-353
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_84_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Acute lymphoblastic leukemia as secondary malignancy in a case of
           Ewing's sarcoma on treatment

    • Authors: Satyam Satyarth, Sonia Parikh, Asha Anand, Jyoti Sawhney, Harsha Panchal, Apurva Patel, Sandeep Shah
      Pages: 354 - 356
      Abstract: Satyam Satyarth, Sonia Parikh, Asha Anand, Jyoti Sawhney, Harsha Panchal, Apurva Patel, Sandeep Shah
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):354-356
      The survival of Ewing's sarcoma (ES) has improved due to advances in both local and systemic therapy. This has given rise to an increased detection of second malignant neoplasms which can be in the form of solid tumors and hematological malignancies. The most common hematological malignancies are acute myeloid leukemia/myelodysplastic syndrome. Acute lymphoblastic leukemia (ALL) is relatively uncommon in occurrence in this setting. Furthermore, the average refractory period for hematological malignancies varies from 3 to 5 years. We report a case of a young female who developed ALL while on adjuvant therapy for ES.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):354-356
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_110_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Unusual presentation of metanephric stromal tumor in a neonate

    • Authors: Prashant Sadashiv Patil, Abhaya Gupta, Rahul Gupta, Paras L Kothari, Geeta Kekre, Kedar Mudkhedkar, Vishesh Dikshit
      Pages: 357 - 359
      Abstract: Prashant Sadashiv Patil, Abhaya Gupta, Rahul Gupta, Paras L Kothari, Geeta Kekre, Kedar Mudkhedkar, Vishesh Dikshit
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):357-359
      Metanephric stromal tumor (MST) of kidney is an under-reported benign stromal specific renal neoplasm with good prognosis. This tumor is to be differentiated from congenital mesoblastic nephroma and clear-cell sarcoma of the kidney. In this case report, we describe the imaging, gross, and microscopic features of MST with ischemic left kidney in a 1-month-old child and discuss treatment with relevant literature.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):357-359
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_27_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • A case report of newly diagnosed epithelial ovarian carcinoma presenting
           with spontaneous tumor lysis syndrome and its successful management with
           rasburicase

    • Authors: Deepak Kumar Shukla, Dinesh Gupta, Arun Aggarwal, Deepak Kumar
      Pages: 360 - 362
      Abstract: Deepak Kumar Shukla, Dinesh Gupta, Arun Aggarwal, Deepak Kumar
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):360-362
      Tumor Lysis Syndrome (TLS) commonly occurs in hematological malignancies, but it is very rare in patients with a solid tumor. In cases of solid tumors, TLS usually occurs spontaneously or after the initiation of anticancer therapy, and it has a high mortality rate. This syndrome consists of a constellation of laboratory findings such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia known as laboratory TLS. When clinical complications such as seizures, acute renal failure, and cardiac dysrhythmias occur in patients with laboratory TLS, the syndrome is called clinical TLS. The present case report is sixth in the series and probably the first case report of spontaneous TLS in a newly diagnosed patient of epithelial ovarian cancer and also shows the effectiveness of single dose (1.5 mg) of rasburicase along with adequate hydration to rapidly reverse TLS and also timely initiation of definitive treatment. The patient was then able to complete successfully the planned neoadjuvant chemotherapy and surgery without any long-term sequela.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):360-362
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_23_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • A novel presentation of cutaneous angiosarcoma: A case report and review

    • Authors: Sonali Bajaj, Prafulla Kumar Sharma, Imroz Singh Sachdev, Minakshi Bhardhwaj
      Pages: 363 - 366
      Abstract: Sonali Bajaj, Prafulla Kumar Sharma, Imroz Singh Sachdev, Minakshi Bhardhwaj
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):363-366
      We report a case of a 70-year-old male, with slowly widening induration, ulceration, and oozing for 3 months on the scalp and face. The diagnosis of aggressive cutaneous angiosarcoma was made on histopathology and immunochemistry from the biopsy material from the involved area of the skin.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):363-366
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_81_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Pilomatrix carcinoma masquerading as breast carcinoma

    • Authors: Trupti Pai, Shweta R Harwani, Asawari Patil, Ayushi Sahay, Tanuja Shet, Vani Parmar, Tabassum Wadasadawala, Sangeeta B Desai
      Pages: 367 - 370
      Abstract: Trupti Pai, Shweta R Harwani, Asawari Patil, Ayushi Sahay, Tanuja Shet, Vani Parmar, Tabassum Wadasadawala, Sangeeta B Desai
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):367-370
      Pilomatrix carcinoma is an exceedingly rare skin adnexal neoplasm derived from piliferous follicles, usually occurring in the head and neck region. Localization of this tumor in the breast is a rarity. We now report an unusual case of a 49-year-old female who presented with a palpable mass in the left breast for 2 years. Mammogram revealed a large, lobulated opacity with calcification, and positron emission tomography–computed tomography showed a metabolically active soft tissue mass measuring 15 cm involving all the quadrants of the left breast. Subsequently, the patient underwent radical mastectomy, and histopathologic diagnosis of pilomatrix carcinoma of the breast was offered. Pilomatrix carcinoma, although exceedingly rare, can have an intramammary location and can be misdiagnosed as breast carcinoma on limited material. A high index of suspicion is required to arrive at an accurate diagnosis so as to obviate neoadjuvant chemotherapy.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):367-370
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_118_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Pancreatitis in acute promyelocytic leukemia: Drug-induced or
           differentiation syndrome?

    • Authors: Dibyendu De, Uttam Kumar Nath, Prantar Chakrabarti
      Pages: 371 - 373
      Abstract: Dibyendu De, Uttam Kumar Nath, Prantar Chakrabarti
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):371-373
      Acute promyelocytic leukemia (APL) constitutes about 15% of all acute myeloid leukemia patients and can now be treated even without any chemotherapy, with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO). Acute pancreatitis (AP) is a rare adverse event in APL, which is primarily reported to be secondary to hypertriglyceridemia. Here, we have reported AP developed in a patient of APL, during induction with ATRA and ATO, but it was not associated with hypertriglyceridemia. Rather, it was associated with respiratory distress and weight gain, coincidental leukocytosis, bilateral pleural effusion, and edematous pancreatitis without any necrosis. Hence, AP in this case is diagnosed to be a manifestation of differentiation syndrome, and it responded to steroid.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):371-373
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_36_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Metaplastic carcinoma of breast and neurofibromatosis 1: A rare
           association

    • Authors: Gnanapriya Vellaisamy, Suravi Mohanty, Pritilata Rout, Suraj Manjunath
      Pages: 374 - 376
      Abstract: Gnanapriya Vellaisamy, Suravi Mohanty, Pritilata Rout, Suraj Manjunath
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):374-376
      Neurofibromatosis 1 (NF1) patients are generally at higher risk of developing common malignant tumors such as brain and soft tissue tumors. These patients are 5-fold increased the risk of developing breast cancer by the age of 50 years after that the risk remains the same. The most common reported cancer is infiltrating duct carcinoma. We report a case of 61-year-old female with NF1 presented with pain and breast lump for the past 2 months. On mammography, a retroareolar solid cystic lesion measuring 32 mm × 30 mm × 30 mm was noted which was definitive for malignancy. Right-modified radical mastectomy with axillary lymph node dissection was done which revealed a neoplasm composed of glandular and squamous components. Immunohistochemically, these cells were triple negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2-neu and expressed markers of basal cell differentiation. The final pathological staging was T2N0M0. This is the fourth case report in the English literature with such association. In this case report, we discussed the importance of breast cancer screening in such patients along with a review of the literature.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):374-376
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_7_17
      Issue No: Vol. 38, No. 3 (2017)
       
  • Human leukocyte antigen-B27: The genetic predisposition leading to
           reactive arthritis during induction phase chemotherapy for acute myeloid
           leukemia

    • Authors: Sandip P Bartakke, Abhilasha Ashok Sampagar, Vibha Sanjay Bafna, Putun Patel
      Pages: 377 - 379
      Abstract: Sandip P Bartakke, Abhilasha Ashok Sampagar, Vibha Sanjay Bafna, Putun Patel
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):377-379
      We report a case of reactive arthritis (ReA) during induction phase chemotherapy of a 15-year-old male patient with acute myeloid leukemia (AML) M4 with inv(16), most probably due to a genetic predisposition of being human leukocyte antigen b27 (HLA-B27) positive. The episode of ReA recurred during consolidation therapy; however, the patient was asymptomatic after the completion of treatment. The link between HLA-B27 and a large family of inflammatory rheumatic diseases is a well-established fact, but interestingly, there is also a molecular link between HLA-B27 and hematological malignancies. This case brings to our notice, the common immunological, molecular, and microbiological link between AML, HLA-B27, and ReA. It also emphasizes the fact that clinicians should have a high index of suspicion of HLA-B27 positivity, if a case of AML develops arthritis during chemotherapy, since early introduction of immunosuppressive medications for arthritis may reduce morbidity and prevent delay in the administration of further chemotherapy cycles.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):377-379
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_8_17
      Issue No: Vol. 38, No. 3 (2017)
       
  • Uncommon adverse effects of commonly used chemotherapeutic agents in
           medical oncology practice: A series of two cases of hand-foot syndrome

    • Authors: Waseem Dar, Mir Hussain, Sheikh Aijaz Aziz, Gul Mohammad, Burhan Wani, Muzamil Latief
      Pages: 380 - 382
      Abstract: Waseem Dar, Mir Hussain, Sheikh Aijaz Aziz, Gul Mohammad, Burhan Wani, Muzamil Latief
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):380-382
      Chemotherapy has an increasing potential for cure and palliation of most forms of cancer in different stages. However, its use is associated with a multitude of side effects some very common and few very rare. We present two patients of metastatic nonsmall lung cancer who had severe forms of hand-foot syndrome with two different classes of antineoplastic drugs and have to discontinue chemotherapy.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):380-382
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_70_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Extrarenal extracranial rhabdoid tumor of the pelvis in a young
           adult-management of a challenging case

    • Authors: Bharti Devnani, Ahitagni Biswas, Sameer Bakhshi, Seema Kaushal, Tripti Nakra
      Pages: 383 - 386
      Abstract: Bharti Devnani, Ahitagni Biswas, Sameer Bakhshi, Seema Kaushal, Tripti Nakra
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):383-386
      Rhabdoid tumor commonly occurs in the kidney and has an aggressive clinical course with high mortality. Central nervous system is the most common extrarenal site. Extrarenal extracranial rhabdoid tumor (EERT) is rare. EERT usually presents in childhood, and presentation in adulthood is extremely rare. This tumor is often difficult to diagnose, and there is no established standard of care due to the paucity of cases. We herein report a case of extrarenal rhabdoid tumor of the pelvis in a young adult and discuss the presentation and possible treatment options of this rare tumor.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):383-386
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_108_17
      Issue No: Vol. 38, No. 3 (2017)
       
  • Metastatic epithelioid malignant peripheral nerve sheath tumor in a known
           case of neurofibromatosis-1, cytomorphological appearance, and critical
           analysis of immunohistochemistry

    • Authors: Rakesh Kumar Gupta, Ravindra Kumar Saran, Deepak Ghuliani, Lalit Garg, Abhijit Das
      Pages: 387 - 390
      Abstract: Rakesh Kumar Gupta, Ravindra Kumar Saran, Deepak Ghuliani, Lalit Garg, Abhijit Das
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):387-390
      Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft tissue tumors commonly arising from nerve roots in the extremities with a predilection in neurofibromatosis (NF) patients. MPNSTs are known to behave aggressively, with worse prognosis in nonresectable cases, and a 5-year survival of about 52% and 15% in resectable and unresectable cases, respectively. Although cytological diagnosis in a known case of NF-1 is possible, however, in the absence of any associated syndrome in a sporadic case, it is very challenging to accurately diagnose this tumor. Till date, to the best of our knowledge, only three cases of epithelioid MPNST correctly diagnosed on cytological examination have been described. We are presenting another case of epithelioid MPNST in a 40-year-old patient with stigmata of NF-1 since childhood, diagnosed on fine-needle aspiration cytology from the left flank mass with subsequent histopathology from left inguinal lymph node metastasis.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):387-390
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_113_17
      Issue No: Vol. 38, No. 3 (2017)
       
  • Extrapulmonary tuberculosis of lymph node coexist with diffuse large
           B-cell lymphoma: A case report

    • Authors: Sashi Bhusan Dash, Upasna Das, Niranjan Rout, Sasmita Panda
      Pages: 391 - 393
      Abstract: Sashi Bhusan Dash, Upasna Das, Niranjan Rout, Sasmita Panda
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):391-393
      Extrapulmonary tuberculosis (TB) coexistent with lymphomas in the same organ are rare. Here, we report a case of a 14-year-old male patient who had cauliflower-like ulcerated mass over cervical lymphadenopathy. He was diagnosed extrapulmonary TB. Unresponsiveness of anti tubercular treatment (anti-tubercular) treatment after 6 months, he was diagnosed as diffuse large B-cell lymphoma.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):391-393
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_164_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • A rare extramedullary and extralymphoid presentation of mixed phenotypic
           blastic hematolymphoid neoplasm: A study of two cases

    • Authors: Kiran Ghodke, Prashant Tembhare, Nikhil Patkar, PG Subramanian, Brijesh Arora, Sumeet Gujral
      Pages: 394 - 397
      Abstract: Kiran Ghodke, Prashant Tembhare, Nikhil Patkar, PG Subramanian, Brijesh Arora, Sumeet Gujral
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):394-397
      Mixed phenotype acute leukemia (MPAL) is a rare hematolymphoid neoplasm, representing only 3%–5% of acute leukemia. Although MPAL has been sufficiently described in the literature, its extramedullary presentation as a solitary lesion without leukemic (bone marrow [BM]) involvement is rarely described. We are presenting two cases of mixed phenotypic blastic hematolymphoid neoplasms without leukemic involvement at disease presentation in 8-year-old female and 21-year-old male patients. Both the cases had extralymphatic bone involvement in the form of solitary bone lesion. Initially, there was no leukemic involvement in both the cases, but the second case progressed to acute leukemia during the course of the disease. On immunophenotypic evaluation, both the cases revealed blasts showing unequivocal evidence of myeloid and B-lymphoid lineage commitment. These cases were difficult to categorize either into MPAL as the BM was not involved or into lymphoblastic lymphoma due to coexpression of myeloid differentiation. Therefore, we chose to classify them as a bi/mixed phenotypic blastic hematolymphoid neoplasm. Detailed immunophenotypic analysis either by immunohistochemistry or flow cytometric immunophenotyping is important for the diagnosis of such cases as they have a poor prognosis.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):394-397
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_94_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Affordable and safe health care for all children: Lessons learned from the
           use of peg-asparaginase in a developing country

    • Authors: Dhaarani Jayaraman, Ramya Uppuluri, Venkateswaran Vellaichamy Swaminathan, Meena Sivasankaran, Shivani Patel, Revathi Raj
      Pages: 398 - 400
      Abstract: Dhaarani Jayaraman, Ramya Uppuluri, Venkateswaran Vellaichamy Swaminathan, Meena Sivasankaran, Shivani Patel, Revathi Raj
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):398-400
      Peg-asparaginase has widely replaced the use of conventional asparaginase in treatment of children with acute lymphoblastic leukaemia in developed countries. In developing countries like India, with financial constraints being a part of clinical challenge to the treatment of cancers, uniform use of Peg-asparaginase in all children is not practically possible. However, we found by a retrospective analysis of 211 children treated for acute lymphoblastic leukaemia, uniform use of this drug was feasible with indigenous techniques like storing the drug with strict cold chain maintenance and sharing the drug amongst 2 or 3 patients to reduce the burden on each family. We have not found increased rates of infection or any loss of efficacy of the drug due to prolonged storage.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):398-400
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_110_17
      Issue No: Vol. 38, No. 3 (2017)
       
  • Rhabdomyosarcoma of the iliopsoas: A retroperitoneal misdiagnosis

    • Authors: Animesh Ashutosh Upadhyay
      Pages: 401 - 403
      Abstract: Animesh Ashutosh Upadhyay
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):401-403
      Rhabdomyosarcoma (RMS) is a rare soft tissue sarcoma. The already documented data regarding RMS state that it is more prevalent in males than females and also that its occurrence is more in Caucasians than Asians. The current incidence of RMS is 4.5 cases/million, and thus, it is a very rare cancer. The undifferentiated type is the most aggressive one with a rare presentation in the retroperitoneum. Overall, this case emphasizes that consideration should be given to wide range of diagnosis and that frozen section is the gold standard for a confirmatory diagnosis, as the first biopsy showed benign cells within the tumor. The emphasis on the interventions related to imaging to prevent the chance of aggravated presentation in the terminal stage of somatic comorbidities like loss of power. Radical excision of the mass along with normal iliopsoas tendon was done and referred to a cancer specialty center for further chemotherapy. To the best of my knowledge, this is the only case of RMS of the iliopsoas.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):401-403
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_120_17
      Issue No: Vol. 38, No. 3 (2017)
       
  • Fibroepithelial polyp with sebaceous hyperplasia: A case report

    • Authors: PK Rajeesh Mohammed, Basanta Kumar Choudhury, Radha Prasanna Dalai, Vivek Rana
      Pages: 404 - 406
      Abstract: PK Rajeesh Mohammed, Basanta Kumar Choudhury, Radha Prasanna Dalai, Vivek Rana
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):404-406
      Fibro epithelial Polyp (FEP) is a polypoid outgrowth of epidermis and dermal fibro vascular tissue. This polyp is most commonly found in oral cavity, neck and axilla, though any skin fold may be affected like groin area. We describe a case of a 25-year-old male patient with a growth over the anterior rugae region of hard palate since 3 years. Based on histological appearance, diagnosis of sebaceous gland hyperplasia in fibroepithelial polyp was given which itself is a rare entity, and in our case, it was encountered at the rarest of sites.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):404-406
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_124_17
      Issue No: Vol. 38, No. 3 (2017)
       
  • A novel translocation: t(2;14)(p12;q32) in a case of precursor B-acute
           lymphoblastic leukemia

    • Authors: Prasannakumari Sampathkumar, Shanthi Velusamy, Namrata Rajkumar, M Padma
      Pages: 407 - 408
      Abstract: Prasannakumari Sampathkumar, Shanthi Velusamy, Namrata Rajkumar, M Padma
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):407-408

      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):407-408
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_172_16
      Issue No: Vol. 38, No. 3 (2017)
       
  • Estimation of cancer risk due to exposure to airborne particle emission of
           a commercial three-dimensional printer

    • Authors: Beuy Joob, Viroj Wiwanitkit
      Pages: 409 - 409
      Abstract: Beuy Joob, Viroj Wiwanitkit
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):409-409

      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):409-409
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_118_17
      Issue No: Vol. 38, No. 3 (2017)
       
  • WWOX rs11644322 polymorphism, gemcitabine, and pancreatic cancer

    • Authors: Sora Yasri, Viroj Wiwanitkit, Beuy Joob
      Pages: 409 - 410
      Abstract: Sora Yasri, Viroj Wiwanitkit, Beuy Joob
      Indian Journal of Medical and Paediatric Oncology 2017 38(3):409-410

      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(3):409-410
      PubDate: Tue,17 Oct 2017
      DOI: 10.4103/ijmpo.ijmpo_125_17
      Issue No: Vol. 38, No. 3 (2017)
       
 
 
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