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Publisher: Medknow Publishers   (Total: 354 journals)

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Showing 1 - 200 of 354 Journals sorted alphabetically
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advances in Human Biology     Open Access   (Followers: 2)
African J. for Infertility and Assisted Conception     Open Access  
African J. of Business Ethics     Open Access   (Followers: 6)
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.269, h-index: 10)
African J. of Trauma     Open Access  
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 6)
Anesthesia : Essays and Researches     Open Access   (Followers: 8)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.331, h-index: 15)
Annals of Bioanthropology     Open Access   (Followers: 4)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.408, h-index: 15)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.308, h-index: 14)
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 7, SJR: 0.441, h-index: 10)
Annals of Saudi Medicine     Open Access   (SJR: 0.24, h-index: 29)
Annals of Thoracic Medicine     Open Access   (Followers: 4, SJR: 0.388, h-index: 19)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 15, SJR: 0.148, h-index: 5)
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Intl. Surgery     Open Access   (Followers: 10)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Pharmacy Practice     Open Access   (Followers: 6)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 3)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.879, h-index: 49)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 2, SJR: 0.362, h-index: 10)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Cancer Translational Medicine     Open Access   (Followers: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 1)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 12, SJR: 0.82, h-index: 12)
Contemporary Clinical Dentistry     Open Access   (Followers: 4)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.339, h-index: 19)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.131, h-index: 4)
Dental Research J.     Open Access   (Followers: 11)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 5, SJR: 0.205, h-index: 22)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.121, h-index: 3)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Orthopaedic J.     Open Access   (Followers: 1)
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.473, h-index: 8)
Environmental Disease     Open Access   (Followers: 2)
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.496, h-index: 11)
European J. of General Dentistry     Open Access   (Followers: 1)
European J. of Prosthodontics     Open Access   (Followers: 3)
European J. of Psychology and Educational Studies     Open Access   (Followers: 9)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.107, h-index: 5)
Genome Integrity     Open Access   (Followers: 4, SJR: 1.227, h-index: 12)
Global J. of Transfusion Medicine     Open Access   (Followers: 2)
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
IJS Short Reports     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 8, SJR: 0.302, h-index: 13)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (SJR: 0.318, h-index: 26)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.618, h-index: 16)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.307, h-index: 16)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.243, h-index: 24)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.448, h-index: 16)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 3, SJR: 0.563, h-index: 29)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.292, h-index: 9)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.53, h-index: 34)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.716, h-index: 60)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.207, h-index: 31)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.233, h-index: 12)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.213, h-index: 5)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 4, SJR: 0.203, h-index: 13)
Indian J. of Ophthalmology     Open Access   (Followers: 5, SJR: 0.536, h-index: 34)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 10, SJR: 0.393, h-index: 15)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.218, h-index: 5)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.35, h-index: 12)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 1, SJR: 0.285, h-index: 22)
Indian J. of Pharmacology     Open Access   (SJR: 0.347, h-index: 44)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.303, h-index: 13)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.496, h-index: 15)
Indian J. of Psychological Medicine     Open Access   (Followers: 1, SJR: 0.344, h-index: 9)
Indian J. of Public Health     Open Access   (Followers: 1, SJR: 0.444, h-index: 17)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4, SJR: 0.253, h-index: 14)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.169, h-index: 7)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.313, h-index: 9)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.366, h-index: 16)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 4, SJR: 0.229, h-index: 13)
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 7)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.239, h-index: 4)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.523, h-index: 15)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 7, SJR: 0.611, h-index: 9)
Intl. J. of Trichology     Open Access   (SJR: 0.37, h-index: 10)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 5)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 3)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 4, SJR: 0.427, h-index: 15)
J. of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 8, SJR: 0.416, h-index: 14)
J. of Applied Hematology     Open Access  
J. of Association of Chest Physicians     Open Access   (Followers: 2)
J. of Basic and Clinical Reproductive Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Therapeutics     Open Access   (Followers: 4, SJR: 0.359, h-index: 21)
J. of Carcinogenesis     Open Access   (Followers: 1, SJR: 1.152, h-index: 26)
J. of Cardiothoracic Trauma     Open Access  
J. of Cardiovascular Disease Research     Open Access   (Followers: 3, SJR: 0.351, h-index: 13)
J. of Cardiovascular Echography     Open Access   (SJR: 0.134, h-index: 2)
J. of Cleft Lip Palate and Craniofacial Anomalies     Open Access   (Followers: 2)
J. of Clinical and Preventive Cardiology     Open Access   (Followers: 1)
J. of Clinical Imaging Science     Open Access   (Followers: 1, SJR: 0.277, h-index: 8)
J. of Clinical Neonatology     Open Access   (Followers: 1)
J. of Clinical Ophthalmology and Research     Open Access   (Followers: 2)
J. of Clinical Sciences     Open Access  
J. of Conservative Dentistry     Open Access   (Followers: 4, SJR: 0.532, h-index: 10)
J. of Craniovertebral Junction and Spine     Open Access   (Followers: 4, SJR: 0.199, h-index: 9)
J. of Current Medical Research and Practice     Open Access  
J. of Current Research in Scientific Medicine     Open Access  
J. of Cutaneous and Aesthetic Surgery     Open Access   (Followers: 1)
J. of Cytology     Open Access   (Followers: 1, SJR: 0.274, h-index: 9)
J. of Dental and Allied Sciences     Open Access   (Followers: 2)
J. of Dental Implants     Open Access   (Followers: 7)
J. of Dental Lasers     Open Access   (Followers: 2)
J. of Dental Research and Review     Open Access   (Followers: 1)
J. of Digestive Endoscopy     Open Access   (Followers: 3)
J. of Dr. NTR University of Health Sciences     Open Access  
J. of Earth, Environment and Health Sciences     Open Access   (Followers: 1)
J. of Education and Ethics in Dentistry     Open Access   (Followers: 5)
J. of Education and Health Promotion     Open Access   (Followers: 5)
J. of Emergencies, Trauma and Shock     Open Access   (Followers: 9, SJR: 0.353, h-index: 14)
J. of Engineering and Technology     Open Access   (Followers: 6)
J. of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
J. of Family and Community Medicine     Open Access   (Followers: 2)
J. of Family Medicine and Primary Care     Open Access   (Followers: 11)

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Journal Cover Indian Journal of Medical and Paediatric Oncology
  [SJR: 0.292]   [H-I: 9]   [0 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 0971-5851 - ISSN (Online) 0975-2129
   Published by Medknow Publishers Homepage  [354 journals]
  • Small HER2 positive breast cancer: When is enough?

    • Authors: Randeep Singh, Sudeep Gupta
      Pages: 1 - 3
      Abstract: Randeep Singh, Sudeep Gupta
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):1-3

      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):1-3
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_12_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • An epidemiological review of sacrococcygeal teratoma over five years in a
           tertiary care hospital

    • Authors: Mukhopadhyay Bedabrata, Das Chhanda, Sengupta Moumita, Saha Ashis Kumar, Mukhopadhyay Madhumita, Mukhopadhyay Biswanath
      Pages: 4 - 7
      Abstract: Mukhopadhyay Bedabrata, Das Chhanda, Sengupta Moumita, Saha Ashis Kumar, Mukhopadhyay Madhumita, Mukhopadhyay Biswanath
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):4-7
      Background: Teratoma refers to neoplasm containing at least two germ cell layers derivatives foreign to the site of origin. Sacrococcygeal teratoma is most common congenital tumor commonly present as an exophytic mass of varying size at coccyx. Aims and Objectives: (1) The aim is to find age, sex, and clinical presentation of cases of sacrococcygeal teratoma. (2) Application of American Academy of Pediatrics' surgical section classification and histological grading in all cases. Materials and Methods: A retrospective, observational study was conducted in the Department of Pathology in collaboration with the Department of Pediatric Surgery from February 2009 to January 2014. A total 13 cases of sacrococcygeal teratoma were included in the present study. The records of these patients were reviewed, and clinical profiles were noted. An average 12 slides were examined in each case to evaluate histological type and grades. Results: A retrospective study was conducted including thirteen cases of histologically confirmed sacrococcygeal teratoma over 5 years period. Male to female ratio was 1:2. As per as age distribution is concerned, 3 neonates (23%) presented with sacrococcygeal mass. Associated congenital malformation was seen in 2 cases (15.4%). According to the American Academy of Pediatrics (Altman's) classification, 23% of cases were Type I, 31% of cases patients Type II, 31% of cases Type III and 15% were for Type IV. The significant presacral component was noted in all malignant tumors. Conclusion: Two clinical patterns were observed in sacrococcygeal teratoma related to the age of presentation. As sacrococcygeal teratoma has potential to become malignant, meticulous search for the malignant component is required for histopathological categorization.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):4-7
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_239_14
      Issue No: Vol. 39, No. 1 (2018)
       
  • Neutrophil-to-lymphocyte ratio: A surrogate marker for prognosis of oral
           squamous cell carcinoma

    • Authors: R Mahalakshmi, Karen Boaz, N Srikant, Mohan Baliga, Premalatha Shetty, Mukul Prasad, Shweta Yellapurkar, Amitha J Lewis
      Pages: 8 - 12
      Abstract: R Mahalakshmi, Karen Boaz, N Srikant, Mohan Baliga, Premalatha Shetty, Mukul Prasad, Shweta Yellapurkar, Amitha J Lewis
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):8-12
      Context: Recent studies show that enzymatic contents of the neutrophil granules have a remarkable ability to modulate the tumor microenvironment by causing apoptosis of T-lymphocytes which leaves the host's cell-mediated immunity at stake. The preoperative neutrophil to lymphocyte ratio (NLR) is considered to be an indicator of the immune status of the patients with oral squamous cell carcinoma (OSCC), which will thereby help in predicting the course of the disease. Aims: The aim is to assess the NLR and histopathological prognostic factors pertinent to infiltration of the surrounding structures and correlate them with the clinical prognostic outcomes of OSCC. Settings and Design: This retrospective study involved the retrieval of formalin-fixed, paraffin-embedded, hematoxylin, and eosin-stained sections of 55 cases of OSCC from the departmental archives from 2006 to 2014. Subjects and Methods: Grading of each case was done by Bryne's grading system. The preoperative complete blood counts, relevant case history, and clinical data of the patients involved in the study were collected from the institutional medical records. The NLR was calculated by dividing the serum neutrophil count by the serum lymphocyte count. Statistical Analysis Used: The median NLR was compared between the controls and OSCC cases using Wilcoxon-signed rank test, and the Kaplan-Meier survival analysis was carried out to predict the survival and recurrence status of OSCC. Results: Higher NLR was seen in lymph node and margin-involved cases and also in patients who had tumor recurrence. Kaplan-Meier survival analysis showed that the mean survival dropped from 26 to 4.5 months when NLR ≥5 (P = 0.052). Conclusion: Neutrophil-to-lymphocyte ratio can be used as a prognosticator of survival, recurrence, lymph node status, and margin status in OSCC.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):8-12
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_2_16
      Issue No: Vol. 39, No. 1 (2018)
       
  • Pediatric nonblastic non-hodgkin's lymphoma: A perspective from
           India

    • Authors: Venkatraman Radhakrishnan, PM Shoufeej, Sidharth Totadri, Prasanth Ganesan, Trivadi Ganesan, Tenali Sagar
      Pages: 13 - 17
      Abstract: Venkatraman Radhakrishnan, PM Shoufeej, Sidharth Totadri, Prasanth Ganesan, Trivadi Ganesan, Tenali Sagar
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):13-17
      Background: There is a paucity of data on pediatric nonblastic non-Hodgkin's lymphoma (NHL) from developing countries. We conducted this study to study outcome and identify risk factors that can predict survival in pediatric nonblastic NHL at our center. Methods: Patients <18 years of age who were diagnosed with nonlymphoblastic NHL at our hospital from January 1, 2005, to December 31, 2014, were included. Data were collected retrospectively from case records. Results: One hundred and two patients with median age of 12 years (range: 1–18) were included in the study. There were 69/102 (68%) male and 33/102 (32%) female patients. The most common histological diagnosis was Burkitt's lymphoma (BL) in 59/102 (58%) patients followed by anaplastic large cell lymphoma (ALCL) in 28/102 (28%) patients and diffuse large B-cell lymphoma (DLBCL) in 12/102 (12%) patients, T-cell lymphoma in 2/102 patients, and primary mediastinal B-cell lymphoma in 1/102 patients. The LMB-89 protocol was the most common protocol used for treatment in 74/102 (72%) patients. The 2-year event-free survival (EFS) for patients with BL, ALCL, and DLBCL was 72%, 55.8%, and 27.5%, respectively (P = 0.037). On univariate analysis, factors that significantly predicted poor EFS included non-BL histological subtype, poor performance status, malnutrition, use of less intense chemotherapy, and not achieving complete response on interim radiological assessment. Conclusions: Outcomes in nonblastic NHL from our center are worse compared to data from the west. This is because a large proportion of patients present with advanced stage and in moribund condition. Patients with BL have better outcome compared to other subtypes.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):13-17
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_42_16
      Issue No: Vol. 39, No. 1 (2018)
       
  • Controversies on tumor thickness versus nodal metastasis in oral squamous
           cell carcinomas revealed: A histopathologist's perspective

    • Authors: Vandana Reddy, Vijay Wadhwan, Munish Reddy, Arvind Venkatesh
      Pages: 18 - 22
      Abstract: Vandana Reddy, Vijay Wadhwan, Munish Reddy, Arvind Venkatesh
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):18-22
      Background: Cervical metastasis has a tremendous impact on prognosis in patients with head and neck squamous cell carcinomas (HNSCCs). However, to date management of clinically negative neck in HNSCC is still a controversial subject. Tumor thickness (TT) is a strong predictor for lymph node involvement in oral squamous cell carcinomas (SCCs). However, controversy exists about the optimal TT cutoff point for a clinically relevant risk to the neck. Aim and Objectives: The aim is to evaluate the relationship between TT and the risk of cervical lymph node involvement and to determine optimal TT cutoff point for prompting prophylactic neck management. Materials and Methods: The clinical files and histological sections of 35 SCC (T1/T2) at buccal mucosa site from clinically determined N0 patients were retrospectively analyzed who underwent surgical treatment of their primary lesion with simultaneous neck dissection. An ocular micrometer was used to measure the TT both in exophytic and ulcerated lesions. Chi-square contingency tables were used to correlate TT and other clinicopathological parameters with metastasis in the neck. Results: Clinically, negative necks turned out pathologically positive in 42.8% (n = 15/35). In the group in which tumor depth exceeded 1.5 mm, the metastatic rate was 86.7% (13/15). In contrast, when the depth of invasion was <1.5 mm, the incidence of cervical metastasis was 13.3% (2/15) irrespective of the 2 stages. Conclusion: TT is a highly significant, objectively measurable prognostic factor in early stage oral cancers and elective neck therapy is indicated for tumors exceeding 1.5 mm invasion.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):18-22
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_45_16
      Issue No: Vol. 39, No. 1 (2018)
       
  • Renal cell cancer: Clinicopathological profile and survival outcomes

    • Authors: Priya Tiwari, Lalit Kumar, Geetika Singh, Amlesh Seth, Sanjay Thulkar
      Pages: 23 - 27
      Abstract: Priya Tiwari, Lalit Kumar, Geetika Singh, Amlesh Seth, Sanjay Thulkar
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):23-27
      Background: The incidence of renal cell cancer (RCC) is increasing worldwide. However, scant information is available from the Indian subcontinent regarding its clinicopathological characteristics and survival outcomes. We retrospectively analyzed data of patients suffering from RCC at our center over the last one decade (2004–2013) to generate information on these aspects. Materials and Methods: Case records of 423 patients treated between 2004 and 2013 were retrospectively analyzed. Baseline characteristics, histopathological information, and survival outcomes were assessed. Overall survival was calculated from the time of diagnosis to death due to any cause. Results: The median age was 52 years (range: 18–87 years). Male: female ratio was 3.5:1. The median duration of symptoms was 3 months (range: 0–24 months). Thirty-five patients (8.3%) were detected in asymptomatic state. The most common symptom was hematuria (53.2%) followed by flank pain (46.3%). The most common histology was clear cell subtype (71.4%). Two hundred and ninety-three (69.3%) patients presented with nonmetastatic disease whereas 130 (30.7%) had upfront metastatic disease. Five-year survival in Stages 1, 2, 3, and 4 was 92.7%, 72.9%, 54.6%, and 11.5%, respectively. Conclusion: Younger age, higher male–female ratio, lower proportion of asymptomatic patients, higher proportion of advanced stage at diagnosis, and lower stage-wise survival were some of the key findings.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):23-27
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_126_16
      Issue No: Vol. 39, No. 1 (2018)
       
  • Androgen receptor expression in triple negative breast cancer - Study from
           a tertiary health care center in South India

    • Authors: Rashmi Patnayak, Amitabh Jena, Dandumudu Bhargavi, Amit Kumar Chowhan
      Pages: 28 - 31
      Abstract: Rashmi Patnayak, Amitabh Jena, Dandumudu Bhargavi, Amit Kumar Chowhan
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):28-31
      Background: The treatment of breast cancer is based on a multi-modality approach. Analysis of the hormone receptor has been accepted as a standard procedure, in the routine management of breast cancer patients. Triple negative breast cancers (TNBCs) are those which are negative for expression of all three markers, i.e., estrogen receptor, progesterone receptor (PR), and human epidermal growth factor receptor. High expression of Ki-67, a proliferation index, has been associated with a worse prognosis in TNBC. TN cancers are aggressive in nature as they do not respond to routine targeted therapy. The role of the androgen receptor (AR) in breast carcinomas is important as AR has been suggested as a potential therapeutic target. We did this study to assess AR immunoreactivity in TNBCs and correlate with Ki-67 index. Materials and Methods: In this study group, there were 45 cases of TN invasive breast carcinomas. These tumors were analyzed with respect to AR and Ki-67 index. Results: Of 45 TN breast carcinomas analyzed, 42 were infiltrating duct cell carcinoma (IDCC) of not otherwise specified type. There were one medullary and two metaplastic carcinomas. The median age was 46 years. AR was positive in 20% (9/45) of cases. All the AR positive cases were an IDCC (nos). Out of the nine AR positive cases, six showed positivity for Ki-67. The statistical analysis using Pearson's Chi-squared method did not reveal any correlation between AR and Ki-67 index (P = 0.574). Conclusion: Although our study did not reveal any statistically significant correlation between AR and Ki-67 index, assessment of AR status in TNBC patients is desirable as it may help to develop a targeted therapy in future in these aggressive cancers.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):28-31
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_4_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • Clinicopathological profile of anaplastic lymphoma kinase-positive
           nonsmall cell lung cancer: An Indian perspective

    • Authors: AP Dubey, Nikhil Pathi, Anvesh Rathore, S Viswanath, Abhishek Pathak, Rahul Sud, SK Rai
      Pages: 32 - 35
      Abstract: AP Dubey, Nikhil Pathi, Anvesh Rathore, S Viswanath, Abhishek Pathak, Rahul Sud, SK Rai
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):32-35
      Background: A novel fusion gene of echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) has been identified in a subset of non-small-cell lung cancers (NSCLCs). Patients with the ALK-EML4 fusion gene demonstrate unique clinicopathological and physiological characteristics. Here we present an analysis of clinicopathological profile of patients of metastatic adenocarcinoma harboring the ALK-EML4 fusion gene. Methods: A retrospective analysis of advanced ALK positive NSCLC, who presented at this tertiary care hospital of armed forces from September 2014 to December 2016 was conducted. The primary goal was to evaluate demographic and clinicopathological profile of ALK positive advanced NSCLC. Detection of ALK fusion was done by IHC on formalin fixed paraffin embedded cell blocks. Results: Out of 270 patients of NSCLC, 15 (7.4%) tested positive for ALK-EML4 fusion. Rate of positivity was higher in females (13.7%) than in males (5%). The correlation of the ALK-EML4 fusion gene and clinicopathological characteristics of NSCLC patients demonstrated a significant difference in smoking status, histological types, stage, and metastatic pattern. Conclusion: Our analysis indicated that ALK-EML4 positive NSCLC comprised a unique subgroup of adenocarcinomas with distinct clinicopathological and radiological characteristics. Incidence of ALK positivity was found to be higher in females and never smokers. These patients have distinct pathological and radiological characteristics.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):32-35
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_19_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • Microsatellite instability in stage II and III colorectal cancer: Patterns
           and profile

    • Authors: AP Dubey, S Vishwanath, P Nikhil, Anvesh Rathore, Abhishek Pathak, Rakesh Kumar
      Pages: 36 - 41
      Abstract: AP Dubey, S Vishwanath, P Nikhil, Anvesh Rathore, Abhishek Pathak, Rakesh Kumar
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):36-41
      Introduction: Around 80% of colorectal carcinoma are associated with chromosomal instability while rest of 20% are euploid, possessing defect in mismatch repair system (MMR) quintessential for surveillance and correction of errors introduced into microsatellites. The microsatellite instability (MSI) phenotype has three major clinical applications: prognosis of colorectal cancer (CRC), prediction of response to 5 fluorouracil, and irinotecan, and genetic assessment of Lynch syndrome. Materials and Methods: We analyzed all Stage II and Stage III colorectal cancer (CRC) for MSI, who presented at Army Hospital, Research and Referral, New Delhi, from January 2014 to December 2016. Although patients of Stage II CRC were taken throughout the study period, Stage III CRC was included in last 1½ years to compare the prevalence of MSI in these two subsets of patients. Results: 26.2% of Stage II and 11.3% of Stage III patients were found to be MSI-high (MSI-H) (P = 0.04). Nineteen (86%) of 22 MSI-H patients were below 30 years of age (P = 0.01). Of 22 MSI-H patients, 18 had right-sided tumors (P = 0.03) and only three patients had rectal tumors. Most common pattern of MSI-H tumors was loss of expression of MLH1 and PMS2, seen in 15 of 16 (88%) of Stage II and three of 6 (50%) of Stage III CRC (P = 0.04). Conclusion: We conclude higher prevalence of MSI-H tumors in Stage II, as compared to Stage III CRC, which was demonstrated slightly higher in our study compared to published literature. MSI-H tumors tend to occur with high frequency in younger population, with right-sided colonic tumors, histopathology characterized by mucinous subtype with high prevalence of tumor infiltrating lymphocytes. Loss of expression of two MMR proteins, namely, PMS2 and MLH1 has been identified in most of MSI-H patients of our study, of which 86% were <30 years of age. This is in contrast to observation in previous studies where loss of PMS2 and MLH1 proteins was observed in older (>70 years) patients with MSI-H tumors, and in younger patients, MSI-H status was associated with loss of MLH1, MSH2, and MSH6.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):36-41
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_35_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • Non-Hodgkin&#39;s lymphoma in Northern India: An analysis of
           clinical features of 241 cases

    • Authors: Devinder Singh Sandhu, Atul Sharma, Lalit Kumar
      Pages: 42 - 45
      Abstract: Devinder Singh Sandhu, Atul Sharma, Lalit Kumar
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):42-45
      Background: Geographic variations with regard to incidence, clinical presentation, and histological subtypes are known to occur in several cancers. This study was aimed to see if similar differences existed in non-Hodgkin's lymphoma (NHL) also during pre-immunohistochemical era. Materials and Methods: Cases of NHL seen at Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi from January 1997 to December 2000, were analyzed for baseline clinical features and histology. Results: Total cases: 241, median age: 47 years (range 2–84 years), male-female ratio: 2.2:1, primary extranodal NHL: 44.2%, the most common histological subtype: Diffuse large cell (6.2% of the cases). Conclusion: Our patients presented at younger median age, had more male to female ratio, had diffuse large cell histology as the most common histological subtype.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):42-45
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_36_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • Outcomes with palliative weekly paclitaxel in advanced, recurrent, and
           metastatic esophageal cancer - Real world experience

    • Authors: Amit Joshi, Vanita Noronha, Avinash Pandey, Vijay Patil, Aseem Samar, Abhishek Mahajan, Amit Janu, Kumar Prabhash
      Pages: 46 - 51
      Abstract: Amit Joshi, Vanita Noronha, Avinash Pandey, Vijay Patil, Aseem Samar, Abhishek Mahajan, Amit Janu, Kumar Prabhash
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):46-51
      Background: In advanced esophageal cancer, combination chemotherapy regimens provide effective palliation but result in substantial toxicity. Aim: The aim of the study was to evaluate outcomes of recurrent and metastatic esophageal carcinoma treated with weekly paclitaxel. Objectives: The objective of the study was to determine the clinical and laboratory factors predicting response and affecting overall survival (OS) in patients receiving palliative chemotherapy for advanced esophageal/gastroesophageal cancer. Materials and Methods: Retrospective analysis of patients with advanced esophageal cancer, not amenable to definitive intent therapy that was treated with intravenous weekly paclitaxel was done. Progression-free survival (PFS) and OS were calculated with Kaplan–Meir analysis while factors affecting outcome were subjected to log rank test and multivariate analysis. Results: Between September 2010 and October 2014, 350 patients were included in analysis. Median follow-up is 8 months. Median age was 55 years, with a male:female ratio of 2.4:1. Nearly 34.5% were mid esophageal and 51% were lower third and gastroesophageal junction tumors. Almost 58% of the tumors had squamous histology. Performance status was >2 in 25.4%. Almost 62% patients had received prior therapy. Median number of cycles of weekly paclitaxel delivered was 12 with median duration of 3 months. Nearly 51% of patients had improvement in dysphagia, with time to symptom improvement of 20 days. In 31% patients, feeding nasogastric tube could be removed. Overall response rate was 32% (complete remission, 2.5% + partial remission, 29.5%). Median PFS was 4.0 months (95% confidence interval [CI]: 3.6–4.3 months) and median OS was 10 months (95% CI: 8.5–11.4 months). Performance status and pretreatment albumin significantly affected OS. Conclusion: Metronomic weekly paclitaxel chemotherapy provides good palliative benefit in advanced unresectable/metastatic esophageal cancer with minimal toxicity. Eastern Cooperative Oncology Group Performance Status (PS 0 and 1) and baseline serum albumin level >3.7 g/dl significantly improved survival.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):46-51
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_39_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • CDX2 expression in gastric carcinoma: A clinicopathological study

    • Authors: Aniket Halder, Mousumi Kundu, Ram Narayan Das, Uttara Chatterjee, Chhanda Datta, Manoj Kr Choudhuri, Bitan Chatterjee
      Pages: 52 - 57
      Abstract: Aniket Halder, Mousumi Kundu, Ram Narayan Das, Uttara Chatterjee, Chhanda Datta, Manoj Kr Choudhuri, Bitan Chatterjee
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):52-57
      Background: Gastric cancer accounts for 7.8% of cancers worldwide and adenocarcinoma is the commonest histological type. Both gastric and intestinal phenotypic cell markers are expressed in gastric carcinomas. CDX2 is an intestinal transcription factor, which can be demonstrated in intestinal metaplasia and gastric carcinomas of the intestinal type. Unlike colorectal carcinomas, the role of CDX2 in gastric carcinomas as a prognostic variable is yet to be established. Ki-67 is a transcription factor expressed in the growth and synthetic phases of the cell cycle. Aims and Objectives: The aims of the study were to analyze CDX2 expression and Ki-67 labeling index in different histological types of gastric carcinomas and their relationship with the patients' clinicopathological parameters. Materials and Methods: A total of 50 gastric carcinoma cases were evaluated histologically and phenotypically, along with assessment of CDX2 expression and Ki-67 labeling index. Gastric carcinomas were grouped into intestinal and diffuse types, according to Lauren classification. A semiquantitative microscopic evaluation of CDX2 expression and Ki-67 labeling index was performed and correlated with the patients' clinicopathological parameters. Results: Increased CDX2 expression correlated with higher proportion of intestinal type gastric carcinomas and a lower proportion of lymph node metastasis, lymphovascular and perineural invasion. On the other hand, high Ki-67 labeling index was found in high grade tumors with lymphovascular invasion. Conclusions: The results of our study suggest that CDX2 might be a useful marker in predicting the prognosis of patients with gastric carcinoma. Accordingly, Ki-67 index seems to be useful in identifying a group of patients with aggressive tumors.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):52-57
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_49_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • Clinicopathological profile and treatment outcomes of bilateral breast
           cancer: A study from tertiary cancer center in South India

    • Authors: Linu Abraham Jacob, Abhishek Anand, Kuntegowdanahalli C Lakshmaiah, Govind K Babu, Dasappa Lokanatha, MC Suresh Babu, Kadabur N Lokesh, Antapura Haleshappa Rudresha, LK Rajeev, Deepak Koppaka
      Pages: 58 - 61
      Abstract: Linu Abraham Jacob, Abhishek Anand, Kuntegowdanahalli C Lakshmaiah, Govind K Babu, Dasappa Lokanatha, MC Suresh Babu, Kadabur N Lokesh, Antapura Haleshappa Rudresha, LK Rajeev, Deepak Koppaka
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):58-61
      Background: Bilateral breast cancer (BBC) is a rare clinical entity with limited data regarding clinicopathological aspects and treatment guidelines. Materials and Methods: This was an observational study of patients diagnosed with BBC from August 2012 to July 2014. Synchronous breast cancers (SBCs) was defined as two tumors diagnosed within an interval of 6 months and metachronous breast cancer (MBC) as second cancer diagnosed after 6 months. Results: Out of 750 breast cancer patients seen during a 2-year period, 35 had BBC. Ten patients were diagnosed as SBC whereas 25 patients as MBC. Among patients with MBC, the average time for development of contralateral breast cancer was 5 years. In 8 patients, the contralateral breast cancer was detected mammography whereas rest 27 patients were detected by clinical breast examination. At a median follow-up of 24 months, 23 (66%) patients were disease free, 9 (26%) patients had disease relapse, and 3 (8%) patients succumbed to the progressive disease. Conclusions: Every patient with breast cancer should be regularly followed up with clinical breast examination at a more frequent interval. The role of frequent clinical breast examination appears more than mammography especially beyond 5 years for early detection of contralateral breast cancer.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):58-61
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_56_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • Clinical profile of multiple myeloma in South India

    • Authors: Chemban Fousad, KV Gangadharan, Mansoor C Abdulla, Ram Naryan, M Jesha Mohammed Ali
      Pages: 62 - 66
      Abstract: Chemban Fousad, KV Gangadharan, Mansoor C Abdulla, Ram Naryan, M Jesha Mohammed Ali
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):62-66
      Background: The incidence of multiple myeloma (MM) is known to be variable according to ethnicity and is increasing rapidly in Asian countries. Because of huge disparities in economy, lack of adequate health-care infrastructure and the lack of access to novel drugs in our country, treatment of multiple myeloma is still a challenge to medical field in India. Methods: This was a descriptive longitudinal study conducted in the medicine and oncology units of a tertiary care hospital in south India. During the one year period of data collection, 37 cases of multiple myeloma were diagnosed, of which 5 cases were excluded. The diagnosis of MM was made based on the International Myeloma Working Group: Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders. The clinical and laboratory characteristics, and treatment were studied. Results: The male to female ratio was 1.3:1. The commonest symptoms noticed were fatigue 32 (100%) and bone pain 31 (96.9%). 6 (18.8%) patients had hypercalcemia and 7 (21.9%) patients had elevated serum creatinine levels. 29 (91%) of 32 had lytic lesions in the skull and 27 (84%) had lytic lesions in the spine. One patient expired during the course of the treatment. 20 (64%) of 32 patients had partial response to treatment, 7 (23%) had complete response and 4 (13%) of them had stable disease not responding to treatment. Conclusions: To conclude, the patients with multiple myeloma in the present study had a male preponderance. Most common symptoms noticed were fatigue and bone pain and majority had spine tenderness on examination. The presentation of MM is non-specific and patient can come with varied presentations at onset. The quality of life and survival in MM patients can be improved significantly if there is access to newer therapies.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):62-66
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_57_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • Combined modality treatment with “dexamethasone, methotrexate,
           ifosfamide, l-asparaginase, and etoposide” chemotherapy and involved
           field radiotherapy for early stage natural Killer/T cell lymphoma with
           local tumor invasiveness: A single-institution study from India

    • Authors: Vineet G Gupta, Ajay Gogia, Lalit Kumar, Atul Sharma, Sameer Bakhshi, Mehar C Sharma, Saumyaranjan Mallick, Ahitagni Biswas, Prashant Mehta, Sanjay Thulkar, Ranjit K Sahoo, Rakesh Kumar
      Pages: 67 - 72
      Abstract: Vineet G Gupta, Ajay Gogia, Lalit Kumar, Atul Sharma, Sameer Bakhshi, Mehar C Sharma, Saumyaranjan Mallick, Ahitagni Biswas, Prashant Mehta, Sanjay Thulkar, Ranjit K Sahoo, Rakesh Kumar
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):67-72
      Context: Patients with early stage extranodal natural killer/T-cell lymphoma, nasal type (ES-NKTCL) and local tumor invasiveness (LTI) show poor treatment outcomes with standard approaches. Dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide (SMILE) is an intensive, highly active protocol mainly studied in advanced/recurrent disease. No prior study has utilized this protocol in high-risk ES-NKTCL. Methods: Between 2011 and 2016, all patients with ES-NKTCL with LTI at presentation were uniformly treated at our institute with a combination of SMILE chemotherapy for 5–6 cycles, and involved-field radiotherapy (IFRT). Records of these patients were retrospectively reviewed. Results: Sixteen patients were identified, 69% stage IE and 31% stage IIE. The majority of patients had B-symptoms (75%), paranasal sinus (PNS) invasion (81%), facial skin invasion (56%), palatal perforation (69%), or orbital extension (56%). 12/16 had B-symptoms, and 6/16 had elevated lactate dehydrogenase. All patients received the entire planned 5–6 cycles. IFRT was delivered after a mean 4 cycles. Complete remission was achieved in 13/15 (87%) patients. At a median follow up of 18.5 months, 1-year progression-free survival and overall survival was 84% and 94%, respectively. Grade 3–4 toxicity was seen in 81%, most commonly neutropenia (75%), anemia (44%), and thromobocytopenia (31%). Six patients required dose adjustments (predominantly in the first 1 or 2 cycles). No treatment-related mortality was noted. Conclusion: SMILE with RT is a toxic but tolerable protocol for ES-NKTCL with LTI with high efficacy. Prospective studies are warranted.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):67-72
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_60_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • Diagnosis of tobacco related cancer has impact on consumption of tobacco
           among family members and friends of patients

    • Authors: Nizamudheen Mangalasseri Pareekutty, Jashma Chanduveettil, Apurva Garg, Swagnik Chakrabarti, Manish Mair, Amol Bansode, Pankaj Chaturvedi
      Pages: 73 - 74
      Abstract: Nizamudheen Mangalasseri Pareekutty, Jashma Chanduveettil, Apurva Garg, Swagnik Chakrabarti, Manish Mair, Amol Bansode, Pankaj Chaturvedi
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):73-74
      Introduction: There is a saying that “cancer cures smoking” as people often quit tobacco after diagnosis of cancer. Very few studies have analyzed the change in tobacco habits of a user after diagnosis of cancer in a relative or friend. Materials and Methods: In this cross-sectional study, 161 friends and relatives of 40 patients treated at Tata Memorial Hospital, Mumbai, India, were interviewed. They were given a questionnaire related to their tobacco habits. The results were analyzed statistically using Wilcoxon signed-rank test and Mann–Whitney test using SPSS. Results: Of the studied individuals, 114 were friends and 47 were blood relatives. 141 used smokeless tobacco, 18 were smokers, and 2 consumed tobacco in both the forms. The mean frequency of tobacco consumption among the friends and relatives before diagnosis of cancer was 12.24 per day and that at the time of interview was 9.76 per day. 35 persons (21.7%) stopped consumption whereas 19 (11.8%) reduced usage after diagnosis of cancer. The difference in mean consumption at median duration of 174 days is statistically significant (P = 0.0005). Conclusions: The diagnosis of tobacco-related cancer has significant impact on the tobacco consumption of friends and relatives. The abstinence rate is comparable to that of various tobacco deaddiction therapies in vogue.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):73-74
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_72_16
      Issue No: Vol. 39, No. 1 (2018)
       
  • Vitamin D role in prevention of cancer: Overview

    • Authors: TG Shrihari
      Pages: 75 - 78
      Abstract: TG Shrihari
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):75-78
      Vitamin D is the name given to a group of fat-soluble prohormones. Two major forms of Vitamin D that are important to humans are Vitamin D2 or ergocalciferol and Vitamin D3 or cholecalciferol. Vitamin D2 is made naturally by the body when the skin is exposed to ultraviolet radiation (in particular, ultraviolet B [UVB] radiation) in sunlight. Vitamin D2 and Vitamin D3 can also be commercially manufactured. The active form of Vitamin D in the body is 1,25-dihydroxyvitamin D or calcitriol, which can be made from either Vitamin D2 or Vitamin D3. Evidence suggests that Vitamin D helps in the prevention of various cancers such as breast cancer, colorectal cancer, prostate cancer, head and neck cancer, and other cancers. This review article briefs about the role of Vitamin D in the prevention of cancer.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):75-78
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_28_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • Trastuzumab emtansine: Antibody-drug conjugate in treatment of human
           epidermal growth factor receptor-2-positive metastatic breast cancer

    • Authors: Ajay Gogia, Jagdish Nigade, Chirag Desai, Babu K Govind, Chetan Deshmukh, Binay Swarup
      Pages: 79 - 87
      Abstract: Ajay Gogia, Jagdish Nigade, Chirag Desai, Babu K Govind, Chetan Deshmukh, Binay Swarup
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):79-87
      The human epidermal growth factor receptor-2 (HER2)-targeted therapies have improved clinical outcomes for patients at any stage of HER2-positive breast cancer (BC). Trastuzumab, a monoclonal antibody that targets the HER2 receptor on BC cells, showed improved survival in metastatic BC (MBC). However, resistance to therapy arises in the majority of patients with advanced disease. Antibody–drug conjugate (ADC) is a relatively new development to deliver cytotoxic drugs specifically to cancer cells. Trastuzumab emtansine (T-DM1) is a HER2-targeted ADC, composed of trastuzumab, a stable thioether linker, and the potent cytotoxic agent, emtansine (DM1, derivative of maytansine). T-DM1 has been approved for use in patients with MBC who have failed prior therapy with trastuzumab and a taxane. Dose finding Phase I study established the maximum tolerated dose at 3.6 mg/kg every 3 weeks. Phase I and II studies of T-DM1 have shown clinical activity and a favorable safety profile in HER2-positive MBC patients. The Phase III randomized EMILIA and TR3RESA trials demonstrated that T-DM1 significantly improves progression-free and overall survival in pretreated HER2-positive MBC patients. Nausea and fatigue are most commonly reported adverse drug reactions with T-DM1 and cardiac toxicity comparable with standard of care therapies. The drug is well tolerated in most patients, with a predictable pharmacokinetic profile and minimal systemic exposure to free cytotoxic DM1. T-DM1 has emerged as an effective therapeutic option for the management of patients with HER2-positive MBC.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):79-87
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_53_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • Ovarian torsion as an unusual presentation of primary bilateral ovarian
           lymphoma

    • Authors: Mohammed Azfar Siddiqui, Sara Sartaj, Syed Wajahat Ali Rizvi, Iraj Alam Khan
      Pages: 88 - 90
      Abstract: Mohammed Azfar Siddiqui, Sara Sartaj, Syed Wajahat Ali Rizvi, Iraj Alam Khan
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):88-90
      Primary ovarian involvement by Burkitt's lymphoma is rare and accounts for 0.5% of nonHodgkin lymphoma and 1.5% of ovarian tumors. We herein describe a very rare case of primary bilateral ovarian lymphoma in a 14-year-old presenting as ovarian torsion.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):88-90
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_68_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • Unilateral vocal cord paralysis secondary to central bronchogenic
           carcinoma

    • Authors: Reddy Ravikanth
      Pages: 91 - 92
      Abstract: Reddy Ravikanth
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):91-92
      Vocal cord paralysis may arise from neurogenic paralysis or mechanical fixation. It is sometimes the only sign of an underlying disease. Thus, it is clinically important to diagnose the primary disease in cases of vocal cord paralysis because many of its potential causes, such as symptom-free malignant tumors, can be fatal or cause serious morbidity if detected late. Radiologic evaluation is often useful for determining the etiology of vocal cord paralysis.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):91-92
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_170_16
      Issue No: Vol. 39, No. 1 (2018)
       
  • A case of alveolar rhabdomyosarcoma with multifocal pyomyositis following
           chemotherapy

    • Authors: Vibhor Sharma, TS Subi, Debashish Chaudhary, Mehul Patel
      Pages: 93 - 95
      Abstract: Vibhor Sharma, TS Subi, Debashish Chaudhary, Mehul Patel
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):93-95
      Pyomyositis is extremely rare after chemotherapy for nonhematological malignancies. We report a patient of alveolar rhabdomyosarcoma, who developed multifocal pyomyositis in bilateral lower limbs after the first cycle of neoadjuvant chemotherapy with vincristine, ifosfamide, mesna, and etoposide. The diagnosis of pyomyositis was reached after ultrasound and contrast-enhanced computed tomography scan of bilateral lower limbs. Staphylococcus and Streptococcus were isolated from pus. This patient was treated with 4 weeks of antibiotics, besides ultrasound-guided pus aspiration and open surgical debridement. To the best of our knowledge, no case of rhabdomyosarcoma with pyomyositis following chemotherapy has been reported so far.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):93-95
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_138_16
      Issue No: Vol. 39, No. 1 (2018)
       
  • Galactogram for investigation of pathological nipple discharge: A
           forgotten arrow in the radiologists' quiver?

    • Authors: Argha Chatterjee, Swapnil Bhagat, Monika Lamba Saini, Sanjeev Verma, Kamal S Saini
      Pages: 96 - 99
      Abstract: Argha Chatterjee, Swapnil Bhagat, Monika Lamba Saini, Sanjeev Verma, Kamal S Saini
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):96-99
      Conventional X-ray galactogram (CG) is an underutilized procedure in modern breast imaging despite offering the highest spatial resolution among all modalities available for imaging of the breast ducts. The superior diagnostic performance of CG as compared to that of both conventional mammogram and high-resolution ultrasonography makes it a valuable imaging modality for the evaluation of pathological nipple discharge (PND). In addition, CG should always be considered in women with bloody nipple discharge but normal ultrasound and mammogram. CG also has an important role in the preoperative localization of intraductal lesions. CG may be especially useful in resource-restricted settings where breast magnetic resonance imaging is not readily available as it can be easily performed at any mammography facility without the need for additional equipment. In this article, we describe two cases of PND, one of benign and the other of malignant etiology, to demonstrate the value of CG in these cases. We also review the current literature and compare CG with other modalities used for imaging of ductal system of the breast.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):96-99
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_33_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • Childhood primary myelofibrosis presented with headache, splenomegaly, and
           severe thrombocytosis: A case report

    • Authors: Athanasios Tragiannidis, Athanasia Apsemidou, Ioannis Liampas, Triantafyllia Koletsa
      Pages: 100 - 102
      Abstract: Athanasios Tragiannidis, Athanasia Apsemidou, Ioannis Liampas, Triantafyllia Koletsa
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):100-102
      Primary myelofibrosis (PMF) is a clonal disorder of a multipotent hematopoietic progenitor cell that occurs predominantly in the elderly age group. We report here an 11-year-old girl who presented with headache, fever, and splenomegaly. Full blood cell count revealed severe thrombocytosis. Laboratory and radiology examinations excluded the diagnosis of essential/reactive thrombocytosis. Bone marrow biopsy showed megakaryocytic hyperplasia, reticulin and collagen fibrosis, and erythroid and myeloid hypoplasia, findings compatible to PMF. The patient was put symptomatically on hydroxyurea and hydration due to thrombocytosis and platelet number decreased. Hematopoietic stem cell transplantation was scheduled to avoid delaying definitive therapy and secondary complications such as infections and transfusion dependency. To the best of our knowledge, this is the first reported case of PMF in childhood in Greece.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):100-102
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_59_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • Multifocal osseous epithelioid hemangioendothelioma involving extremities
           and spine with visceral metastasis

    • Authors: Maitrayee Roy, Rajni Yadav, Tarun Kumar
      Pages: 103 - 105
      Abstract: Maitrayee Roy, Rajni Yadav, Tarun Kumar
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):103-105
      Epithelioid hemangioendothelioma (EH) is a rare locally aggressive intermediate grade malignant vasoformative tumor. Bone is a rarer primary site accounting for less than 1% of all malignant bone tumors. Multicentricity and/or multifocality are a relatively frequent occurrence, most commonly clustered in the bones of lower extremities. The axial skeleton is less commonly affected, and concomitant visceral involvement is rarer. We report a unique case of a 20-year-old male who presented with multiple lytic lesions in the skull vault, vertebral bones, bilateral proximal femur, and both radii and humerii with metastasis to the lungs and liver. A final diagnosis of EH was established on biopsy from the right iliac bone. He initially received multiagent chemotherapy and is currently on antiangiogenic therapy. On follow-up positron emission tomography–computerized tomography done 6 months later, marked reduction in fluoro-D-glucose avidity of the hepatic and most skeletal lesions was noted.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):103-105
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_31_16
      Issue No: Vol. 39, No. 1 (2018)
       
  • Longitudinally extensive transverse myelitis as presenting manifestation
           of lung adenocarcinoma

    • Authors: Davinder Singh Rana, Anshu Rohatgi, Samir Patel, Nikhil Dave, Rajat Agarwal, Pooja Gupta
      Pages: 106 - 108
      Abstract: Davinder Singh Rana, Anshu Rohatgi, Samir Patel, Nikhil Dave, Rajat Agarwal, Pooja Gupta
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):106-108
      Longitudinally extensive transverse myelitis (LETM) is an unusual manifestation of systemic malignancy. It has been mainly reported with lung cancers and lymphoproliferative malignancy. LETM in systemic malignancy can be caused by either intramedullary metastases or paraneoplastic syndrome. Occurrence of LETM as the first manifestation of malignancy has been rarely reported. We present clinical, laboratory, and imaging findings of a 66-year-old man with nonsmall-cell lung (adeno) carcinoma, who presented with LETM without having any cardinal manifestations of lung malignancy. The rarity of the disease and especially such a presentation can cause considerable delay in the diagnosis and treatment.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):106-108
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_55_16
      Issue No: Vol. 39, No. 1 (2018)
       
  • Late recurrence of malignant choroidal melanoma mimicking hepatocellular
           carcinoma

    • Authors: Saphalta Baghmar, Dipanjan Panda, Chhagan Bihari, Shalini Thapar
      Pages: 109 - 110
      Abstract: Saphalta Baghmar, Dipanjan Panda, Chhagan Bihari, Shalini Thapar
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):109-110
      Late recurrence (after more than 10 years) of choroidal melanoma, though infrequent, has been documented well in Western countries. In India, however, this disease being uncommon, there is no data regarding its late recurrence. Here, we report a case of late metastatic manifestation of choroidal melanoma in the form of liver metastases in a 45-year-old man who presented with abdominal pain; metastases to liver occurred 10 years after enucleation of the right eye.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):109-110
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_12_16
      Issue No: Vol. 39, No. 1 (2018)
       
  • Eosinophilic liver abcesses and pyrexia of unknown origin in idiopathic
           hypereosinphilic syndrome: Myeloproliferative or mimic?

    • Authors: Chetana Sen, Krishnarpan Chatterjee
      Pages: 111 - 113
      Abstract: Chetana Sen, Krishnarpan Chatterjee
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):111-113
      We report a case which presented with pyrexia of unknown origin (PUO) with eosinophilia and multiple hypoechoic lesions in the liver resembling secondaries. After secondary causes were ruled out, aspiration of liver lesions revealed eosinophilic abcesses. A diagnosis of idiopathic hypereosinophilic syndrome (HES) was made and the patient responded to steroid therapy. HES remains a diagnosis of exclusion. HES presenting with PUO and liver abcesses is very rare. A high index of suspicion is required to recognize the involvement of different organ systems due to HES.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):111-113
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_25_16
      Issue No: Vol. 39, No. 1 (2018)
       
  • Pseudoepitheliomatous hyperplasia: A diagnostic dilemma

    • Authors: Anubhav Chauhan, Lalit Gupta, Shveta Chauhan
      Pages: 114 - 116
      Abstract: Anubhav Chauhan, Lalit Gupta, Shveta Chauhan
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):114-116
      Pseudoepitheliomatous hyperplasia (PEH) is a benign reactive inflammatory reaction of the epithelial cells to various conditions. It is a diagnostic dilemma which simulates malignancy, especially squamous cell carcinoma (SCC). Many articles of PEH involving the oral mucosa are available on the internet, but ocular involvement is infrequent. The ocular lesion in our case resembled SCC but turned out to be PEH. We report a rare case of PEH in a 20-year-old male.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):114-116
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_198_16
      Issue No: Vol. 39, No. 1 (2018)
       
  • Retroperitoneal mature cystic teratoma in a 3-month-old infant: A case
           report and literature review

    • Authors: Prasanta Kumar Tripathy, Kaumudee Pattnaik, Pradeep Kumar Jena, Hiranya Kishore Mohanty
      Pages: 117 - 119
      Abstract: Prasanta Kumar Tripathy, Kaumudee Pattnaik, Pradeep Kumar Jena, Hiranya Kishore Mohanty
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):117-119
      Retroperitoneal teratoma (RPT) is an exceedingly rare neoplasm in infancy. We came across a 3-month-old infant with large RPT in the left suprarenal area. The tumor was completely excised, and the patient was successfully discharged. Histopathological examination suggested the diagnosis of mature cystic teratoma.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):117-119
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_42_17
      Issue No: Vol. 39, No. 1 (2018)
       
  • SLC19A1 polymorphism and serum methotrexate in patients with acute
           lymphoblastic leukemia

    • Authors: Beuy Joob, Viroj Wiwanitkit
      Pages: 120 - 121
      Abstract: Beuy Joob, Viroj Wiwanitkit
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):120-121
      Acute lymphoblastic leukemia (ALL) is a common pediatric malignancy. Methotrexate is the widely used chemotherapy for ALL. The polymorphism (rs1051296) of SLC19A1 is proposed for its effect on serum methotrexate. To explain this observation, the authors hereby studied the interrelationship between SLC19A1 polymorphism and blood methotrexate level in the patients with ALL. Here, the authors use a quantum chemistry analysis for explaining of this observation.
      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):120-121
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_6_16
      Issue No: Vol. 39, No. 1 (2018)
       
  • Chediak&#8211;Higashi syndrome presented with hemophagocytic
           lymphohistiocytosis

    • Authors: Kamuran Karaman, Sinan Akbayram, Hadi Geylan, Mecnun &#199;etin
      Pages: 122 - 123
      Abstract: Kamuran Karaman, Sinan Akbayram, Hadi Geylan, Mecnun Çetin
      Indian Journal of Medical and Paediatric Oncology 2018 39(1):122-123

      Citation: Indian Journal of Medical and Paediatric Oncology 2018 39(1):122-123
      PubDate: Mon,29 Jan 2018
      DOI: 10.4103/ijmpo.ijmpo_54_16
      Issue No: Vol. 39, No. 1 (2018)
       
 
 
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