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Publisher: Medknow Publishers   (Total: 355 journals)

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Showing 1 - 200 of 355 Journals sorted alphabetically
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advances in Human Biology     Open Access   (Followers: 1)
African J. for Infertility and Assisted Conception     Open Access  
African J. of Business Ethics     Open Access   (Followers: 6)
African J. of Medical and Health Sciences     Open Access   (Followers: 1)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.269, h-index: 10)
African J. of Trauma     Open Access  
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 6)
Anesthesia : Essays and Researches     Open Access   (Followers: 7)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.331, h-index: 15)
Annals of Bioanthropology     Open Access   (Followers: 3)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 12, SJR: 0.408, h-index: 15)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.308, h-index: 14)
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 7, SJR: 0.441, h-index: 10)
Annals of Saudi Medicine     Open Access   (SJR: 0.24, h-index: 29)
Annals of Thoracic Medicine     Open Access   (Followers: 4, SJR: 0.388, h-index: 19)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 15, SJR: 0.148, h-index: 5)
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Intl. Surgery     Open Access   (Followers: 9)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Pharmacy Practice     Open Access   (Followers: 5)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 3)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.879, h-index: 49)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 2, SJR: 0.362, h-index: 10)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Cancer Translational Medicine     Open Access   (Followers: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 1)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access   (Followers: 1)
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 12, SJR: 0.82, h-index: 12)
Contemporary Clinical Dentistry     Open Access   (Followers: 4)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.339, h-index: 19)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.131, h-index: 4)
Dental Research J.     Open Access   (Followers: 9)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 5, SJR: 0.205, h-index: 22)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access  
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.121, h-index: 3)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access  
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Orthopaedic J.     Open Access  
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.473, h-index: 8)
Environmental Disease     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.496, h-index: 11)
European J. of General Dentistry     Open Access   (Followers: 1)
European J. of Prosthodontics     Open Access   (Followers: 2)
European J. of Psychology and Educational Studies     Open Access   (Followers: 7)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.107, h-index: 5)
Genome Integrity     Open Access   (Followers: 4, SJR: 1.227, h-index: 12)
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
IJS Short Reports     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 8, SJR: 0.302, h-index: 13)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (SJR: 0.318, h-index: 26)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.618, h-index: 16)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.307, h-index: 16)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.243, h-index: 24)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.448, h-index: 16)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 3, SJR: 0.563, h-index: 29)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.292, h-index: 9)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.53, h-index: 34)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.716, h-index: 60)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.207, h-index: 31)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 1, SJR: 0.233, h-index: 12)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.213, h-index: 5)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 4, SJR: 0.203, h-index: 13)
Indian J. of Ophthalmology     Open Access   (Followers: 5, SJR: 0.536, h-index: 34)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 9, SJR: 0.393, h-index: 15)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.218, h-index: 5)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.35, h-index: 12)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 1, SJR: 0.285, h-index: 22)
Indian J. of Pharmacology     Open Access   (SJR: 0.347, h-index: 44)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.303, h-index: 13)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.496, h-index: 15)
Indian J. of Psychological Medicine     Open Access   (Followers: 1, SJR: 0.344, h-index: 9)
Indian J. of Public Health     Open Access   (Followers: 1, SJR: 0.444, h-index: 17)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4, SJR: 0.253, h-index: 14)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.169, h-index: 7)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.313, h-index: 9)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.366, h-index: 16)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 3)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 4, SJR: 0.229, h-index: 13)
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 2)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 7)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.239, h-index: 4)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.523, h-index: 15)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 7, SJR: 0.611, h-index: 9)
Intl. J. of Trichology     Open Access   (SJR: 0.37, h-index: 10)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 2)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 4, SJR: 0.427, h-index: 15)
J. of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 8, SJR: 0.416, h-index: 14)
J. of Applied Hematology     Open Access  
J. of Association of Chest Physicians     Open Access   (Followers: 2)
J. of Basic and Clinical Reproductive Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Therapeutics     Open Access   (Followers: 4, SJR: 0.359, h-index: 21)
J. of Carcinogenesis     Open Access   (Followers: 1, SJR: 1.152, h-index: 26)
J. of Cardiothoracic Trauma     Open Access  
J. of Cardiovascular Disease Research     Open Access   (Followers: 3, SJR: 0.351, h-index: 13)
J. of Cardiovascular Echography     Open Access   (SJR: 0.134, h-index: 2)
J. of Cleft Lip Palate and Craniofacial Anomalies     Open Access   (Followers: 2)
J. of Clinical and Preventive Cardiology     Open Access   (Followers: 1)
J. of Clinical Imaging Science     Open Access   (Followers: 1, SJR: 0.277, h-index: 8)
J. of Clinical Neonatology     Open Access   (Followers: 1)
J. of Clinical Ophthalmology and Research     Open Access   (Followers: 2)
J. of Clinical Sciences     Open Access  
J. of Conservative Dentistry     Open Access   (Followers: 4, SJR: 0.532, h-index: 10)
J. of Craniovertebral Junction and Spine     Open Access   (Followers: 4, SJR: 0.199, h-index: 9)
J. of Current Medical Research and Practice     Open Access  
J. of Current Research in Scientific Medicine     Open Access  
J. of Cutaneous and Aesthetic Surgery     Open Access   (Followers: 1)
J. of Cytology     Open Access   (Followers: 1, SJR: 0.274, h-index: 9)
J. of Dental and Allied Sciences     Open Access   (Followers: 1)
J. of Dental Implants     Open Access   (Followers: 7)
J. of Dental Lasers     Open Access   (Followers: 2)
J. of Dental Research and Review     Open Access   (Followers: 1)
J. of Digestive Endoscopy     Open Access   (Followers: 3)
J. of Dr. NTR University of Health Sciences     Open Access  
J. of Earth, Environment and Health Sciences     Open Access   (Followers: 1)
J. of Education and Ethics in Dentistry     Open Access   (Followers: 5)
J. of Education and Health Promotion     Open Access   (Followers: 5)
J. of Emergencies, Trauma and Shock     Open Access   (Followers: 9, SJR: 0.353, h-index: 14)
J. of Engineering and Technology     Open Access   (Followers: 6)
J. of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
J. of Family and Community Medicine     Open Access   (Followers: 2)
J. of Family Medicine and Primary Care     Open Access   (Followers: 9)

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Journal Cover Indian Journal of Medical and Paediatric Oncology
  [SJR: 0.292]   [H-I: 9]   [0 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 0971-5851 - ISSN (Online) 0975-2129
   Published by Medknow Publishers Homepage  [355 journals]
  • Evaluation of metabolic syndrome and related factors in children affected
           by acute lymphoblastic leukemia

    • Authors: Soheila Zareifar, Sezaneh Haghpanah, Eslam Shorafa, Nader Shakibazad, Zohreh Karamizadeh
      Pages: 97 - 102
      Abstract: Soheila Zareifar, Sezaneh Haghpanah, Eslam Shorafa, Nader Shakibazad, Zohreh Karamizadeh
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):97-102
      Introduction: Obesity is among the medical problems in survivors of childhood acute lymphoblastic leukemia (ALL). These patients are at risk of metabolic syndrome (MS). The present study aimed to follow the patients with ALL regarding the incidence of MS. Patients and Methods: This study was conducted on all patients who referred to the oncology clinic from July 2012 to July 2013. The exclusion criteria of the study were ALL relapse, secondary malignancy, hypothyroidism, Down syndrome, and below 2 years of age. ALL had to be diagnosed at least 12 months before enrollment into this study. MS was assessed by serum triglyceride, cholesterol, fasting blood sugar, leptin, and insulin levels. Besides, body mass index (BMI) and blood pressure (BP) were measured at diagnosis and at the last visit. Results: This study was conducted on 53 patients (male = 35, female = 18). At the end of the study, 13 patients (24.53%) were overweight compared to 3 patients at diagnosis (P = 0.04). The mean blood leptin level was higher in overweight patients compared to the others (P = 0.001). MS was detected in 21 patients (39.6%), including 12 males and 9 females. In addition, the BMI Z- score significantly increased over the study period (P = 0.001). Conclusions: Being overweight is a complication of ALL treatment, which is associated with elevated blood leptin level and BMI Z- score. Therefore, MS criteria, such as BP, weight, and serum triglyceride level, should be taken into account in each visit.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):97-102
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_69_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Efficacy and safety of deferasirox in pediatric patients of thalassemia at
           a Tertiary Care Teaching Hospital

    • Authors: Dhaval R Thakor, Chetna K Desai, Jigar D Kapadia, Ram K Dikshit, KM Mehariya
      Pages: 103 - 110
      Abstract: Dhaval R Thakor, Chetna K Desai, Jigar D Kapadia, Ram K Dikshit, KM Mehariya
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):103-110
      Objective: To evaluate efficacy, safety and utilization pattern of deferasirox in paediatric patients of transfusion dependant β Thalassemia Major at a tertiary care teaching hospital in Gujarat. Materials and Methods: This observational, prospective-retrospective, single centre, continuous study was conducted in a tertiary care teaching hospital among paediatric patients of transfusion dependent β Thalassemia Major. Patients treated with deferasirox for not more than 12 weeks were enrolled. Details of blood transfusions, relevant investigations performed every 3 weeks and 3 months and drugs used were recorded in a pretested case record form. Parents were provided with a diary to record the details of ADRs. Data were analyzed for demographic characteristics, number and mean volume of blood transfusions, changes in serum ferritin and iron levels, number and types of ADRs and progression, causality, severity and preventability of ADRs. Results: Of the 60 patients enrolled, one patient was lost to follow up and four withdrew their consent. Of the remaining 55 patients, 36 were boys and 19 were girls (mean age: 6 ± 3.14 years), including patients of 1-3 years (11), 4-6 years (24), 7-10 years (12) and 11-12 years (8). Thirty six patients were born of consanguineous marriages. Adherence to blood transfusion guidelines and deferasirox prescribing and administration guidelines was observed. A serial and significant decrease in mean serum ferritin and serum iron at 3 weeks and 3 months with deferasirox treatment was observed in all age groups except that of 11-12 years. A total of 117 ADRs were observed in 52 patients from 19498 doses, most common being diarrhea (24), raised serum creatinine (15), raised hepatic enzymes (14), abdominal pain (14) and rashes (14). A reduction in dose was required in 32 cases, while a temporary stoppage was indicated in 41 cases. Deferasirox was the possible and probable cause of 65 and 51 ADRs respectively as assessed by WHO-UMC scale. Majority of ADRs were definitely preventable and mild in nature. Conclusion: β Thalassemia Major is more common in males. A rational prescribing of deferasirox was observed. Deferasirox effectively reduced serum ferritin and serum iron levels in these patients.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):103-110
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_103_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Benson's relaxation effect in comparing to systematic desensitization
           on anxiety of female nurses: A randomized clinical trial

    • Authors: Mahbobeh Sajadi, Khatereh Goudarzi, Sharareh Khosravi, Molod Farmahini-Farahani, Abolfazl Mohammadbeig
      Pages: 111 - 115
      Abstract: Mahbobeh Sajadi, Khatereh Goudarzi, Sharareh Khosravi, Molod Farmahini-Farahani, Abolfazl Mohammadbeig
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):111-115
      Introduction: Nursing staffs expose to a high level of anxiety. This study aimed to compare the effect of Benson's relaxation and systematic desensitization methods for decreasing the anxiety score of nurses. Materials and Methods: In a randomized clinical trial, 72 female nurses were assigned randomly to three different groups. Benson's relaxation and systematic desensitization were used as intervention beside control group. After intervention, the Spielberger state-trait anxiety inventory was used for measuring the anxiety score. Analysis of variance (ANOVA), Tukey test, and paired t-test were applied for comparing three group scores. Results: The ANOVA test showed that a significant difference among three groups regarding scores of posttrait and poststate anxiety (P < 0.05). The Tukey test showed that both Benson's relaxation and systematic desensitization methods were effective in decreasing of the anxiety score of nurses. Moreover, the mean change in trait and state anxiety scores at Benson's relaxation and systematic desensitization groups was more than control group, respectively, and was statistically significant. Conclusion: Both Benson's relaxation and systematic desensitization methods are effective in improvement of the state and trait dimensions of anxiety. However, these methods could be applied in stressful situation among medical staffs of students.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):111-115
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_183_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Evaluation of cytotoxicity effects of oleo-gum-resin and its essential oil
           of Ferula assa-foetida and ferulic acid on 4T1 breast cancer cells

    • Authors: Seyyed Majid Bagheri, Amir Abdian Asl, Ali Shams, Seyyed Ali Mirghanizadeh-Bafghi, Zeynab Hafizibarjin
      Pages: 116 - 120
      Abstract: Seyyed Majid Bagheri, Amir Abdian Asl, Ali Shams, Seyyed Ali Mirghanizadeh-Bafghi, Zeynab Hafizibarjin
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):116-120
      Background: Cancer causes significant morbidity and mortality and is a major public health problem worldwide. Breast cancer is a leading cause of cancer-associated mortality in women, and the incidence is also on the rise in the entire world. Medicinal plants have been an important source of several clinically useful anticancer agents. Aim: In this study, we studied the growth inhibitory effect of asafoetida and its essential oil and ferulic acid on antitumor activity using mouse breast cancer cell line. Materials and Methods: For this aim, cells were exposed to these components at different concentrations and for different time durations. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was carried out to characterize the cytotoxicity of the constituents used. Results: Our results showed that all three constituents could inhibit 4T1 cell proliferation. Our MTT assay results showed a significant cytotoxicity effect in a time- and concentration-dependent manner. It also demonstrated that essential oil of asafoetida has a stronger effect in decreasing viability breast cancer cells. Ferulic acid showed a significant effect only at a dose of 500 μg/ml. Conclusions: Based on the results of cellular carried out in this study, we could demonstrate that asafoetida and its essential oil and ferulic acid have inhibitory effect on the growth of breast cancer cell line. As evidenced from these preliminary results, asafoetida and its derivative constituents may be considered as attractive alternatives to serve as lead compounds in drug development for breast cancer as an adjuvant therapy. However, much remains to be done before such agent could be introduced to the clinic.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):116-120
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_60_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Normal tissue complications following hypofractionated chest wall
           radiotherapy in breast cancer patients and their correlation with patient,
           tumor, and treatment characteristics

    • Authors: Mohsin Khan, Shahid A Siddiqui, Manoj K Gupta, Rajeev K Seam, Manish Gupta
      Pages: 121 - 127
      Abstract: Mohsin Khan, Shahid A Siddiqui, Manoj K Gupta, Rajeev K Seam, Manish Gupta
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):121-127
      Introduction: Normal tissue complications following chest wall radiotherapy (RT) are inevitable, and the long-term data on hypofractionation are still limited. To quantify the late effects of hypofractionated RT on cardiac, pulmonary, brachial plexus, and regional lymphatics and their correlation with patient, tumor, and treatment characteristics is the main objective of this study. Materials and Methods: Two hundred and sixteen breast cancer patients following mastectomy were treated with hypofractionated schedules either 40 Gy in 15 fractions or 42.5 Gy in 16 fractions. Common Toxicity Criteria version 3.0 was utilized to quantify the late effects of hypofractionation on cardiac, pulmonary, brachial plexus, and lymphedema at a maximum follow-up of 5 years. Results: Median follow-up was 42 months. Median age was 49 years. 14.8% developed ≥Grade (Gr) 2 late cardiac toxicity. 10.2% developed ≥Gr2 late pulmonary toxicity. There were 28.7% patients who developed ≥Gr2 lymphedema. Sixty-seven out of 216 patients had symptomatic brachial plexopathy at 5-year follow-up. Variables found to increase the incidence of these adverse events included smoking, hypertension, diabetes mellitus, body mass index ≥25, extent of axillary dissection, and use of supraclavicular field. Conclusion: Hypofractionation leads to increased risk of normal tissue complications partly influenced by some patient- and treatment-related factors, but these were manageable and minimally disabling.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):121-127
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_80_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Investigation of vitamin D receptor gene polymorphism in pediatric
           patients with brain cancer

    • Authors: Baris Yilmaz, Gulnur Ayse Tokuc, Ahmet Koc, Edanur Yesil
      Pages: 128 - 132
      Abstract: Baris Yilmaz, Gulnur Ayse Tokuc, Ahmet Koc, Edanur Yesil
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):128-132
      Aim: In recent years, it is believed that Vitamin D may play a protective role in some cancer types. Certain regions of the Vitamin D receptor (VDR) gene may show a genetic difference in structure. The most frequent polymorphisms in this gene are in Taq-1, Fok-1, and Bsm-1 regions. Some adult cancer types are associated with VDR gene polymorphism such as; colorectal carcinoma, breast carcinoma, and prostate carcinoma. Reviewing the medical literature, no such study had been done on children so far. Materials and Methods: We investigated the association of the three most common gene polymorphisms (Taq-1, Fok-1, and Bsm-1 regions) in VDR gene in 32 children with brain tumors and forty control healthy volunteers. Results: We could not find any relationship between childhood brain tumors and VDR gene polymorphism in these three regions. Conclusion: The present results suggest that the Taq-1, Fok-1, and Bsm-1 polymorphism in the VDR gene and pediatric brain cancers have no association.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):128-132
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_22_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • A cross-sectional survey assessing knowledge, attitude, and practice
           regarding oral cancer among private medical and dental practitioners in
           Bhubaneswar City

    • Authors: Avinash Jnaneswar, Bala Subramanya Goutham, Jayashree Pathi, Kunal Jha, Vinay Suresan, Gunjan Kumar
      Pages: 133 - 139
      Abstract: Avinash Jnaneswar, Bala Subramanya Goutham, Jayashree Pathi, Kunal Jha, Vinay Suresan, Gunjan Kumar
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):133-139
      Introduction: Oral cancer is a public health problem giving rise to a great number of disabilities and deaths, but the possibility of survival is astonishingly higher when detected early. Health professionals therefore have an important role and responsibility in the prevention and early detection of oral cancer. They should be in a position to identify all suspicious lesions and to search for specialist opinion as promptly as possible when unsure, while also referring to the most appropriate discipline. Aim: This study aimed to assess the knowledge, attitude, and practices (KAPs) regarding oral cancer among private medical practitioners (MPs) and private dental practitioners (DPs). Materials and Methods: A cross-sectional, questionnaire-based study was conducted among 334 MPs and 201 DPs in Bhubaneswar. A self-designed, close-ended questionnaire containing 28 items was delivered to the practitioners in their clinics. Correlation between KAP among MPs and DPs was done by Karl Pearson's correlation coefficient test. Student's t-test was used to compare the KAP among the practitioners. Results: Of the 535 practitioners approached, 513 filled the questionnaire with a response rate of 95.88%. Significantly, the mean knowledge index was higher among DPs (10.96 ± 1.85). The attitude index was higher in the MPs (6.89 ± 1.11), and the practice index was higher among the DPs (4.95 ± 0.91). Conclusion: The study puts forward the need of further training for both MPs and DPs to increase awareness and to strengthen their abilities to diagnose potentially cancerous intra-oral lesions.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):133-139
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_107_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Pattern of adverse drug reactions to anticancer drugs: A quantitative and
           qualitative analysis

    • Authors: Shruti Singh, DC Dhasmana, Manisha Bisht, Prashant Kumar Singh
      Pages: 140 - 145
      Abstract: Shruti Singh, DC Dhasmana, Manisha Bisht, Prashant Kumar Singh
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):140-145
      Introduction: Anticancer drugs contribute significantly to the global burden of adverse drug reactions (ADRs). Any attempt to quantify their magnitude and provide upgraded knowledge would help oncologists in writing safer prescriptions. Aim: This observational follow-up study was conducted on newly diagnosed cancer patients receiving anticancer therapy with an aim to determine the frequency, severity, causality, predictability, and preventability of ADRs. Subjects and Methods: The patients were followed up for 6 months for the appearance of adverse events. Data were analyzed using IBM SPSS Statistics for Windows, Version 22.0. (Armonk, NY) and presented in the form of descriptive statistics. Results: Each patient was prescribed approximately 6.85 ± 1.51 (mean ± standard error) drugs on average. All the patients (100%) receiving anticancer chemotherapy had ADRs. Alopecia, nausea and vomiting, burning tingling, and numbness were the most frequently encountered ADRs. The incidence of alopecia (P < 0.0004), nausea (P < 0.03), and oral ulceration (P < 0.02) was higher in females. Maximum reactions were of Grade 2 (69.53%). Most of the reactions (75.80%) appeared within 10 days of receiving the first cycle. 99.58% reactions were not serious. According to the WHO – The Uppsala Monitoring Centre criteria, 99.47% ADRs fell in possible category. According to the Naranjo's algorithm, 100% ADRs fell in probable category. About 94.80% reactions were found to be predictable. About 56.47% reactions were probably preventable, and 43.53% reactions were not preventable. Conclusion: Multiple ADRs were seen in newly diagnosed cancer patients. Most of them were predictable, of mild-to-moderate severity, nonserious, and preventable. A majority of the ADRs recovered over time.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):140-145
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_18_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Stigma perceived by women following surgery for breast cancer

    • Authors: Lopamudra Tripathi, Soumitra Shankar Datta, Sanjit Kumar Agrawal, Sanjoy Chatterjee, Rosina Ahmed
      Pages: 146 - 152
      Abstract: Lopamudra Tripathi, Soumitra Shankar Datta, Sanjit Kumar Agrawal, Sanjoy Chatterjee, Rosina Ahmed
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):146-152
      Context: Women undergoing treatment for breast cancer often have psychological morbidity and body image difficulties. The risk factors for increased levels of stigma in women with breast cancer have not been adequately studied. Aims: This study aimed at investigating the associations of high levels of stigma in women with breast cancer. Settings and Design: This cross-sectional study was conducted in a comprehensive cancer center in India and recruited women (n = 134) undergoing surgical treatment for breast cancer. Methods: Body image difficulties, including stigma and affective symptoms, were quantified, alongside disease- and treatment-related variables using standardized questionnaires. Statistical Analysis Used: Univariate analysis followed by multivariate logistic regression was performed to find the risk factors of high levels of stigma related to body image. Results: In the univariate analysis, high levels of stigma were associated with lesser educational attainment (odds ratio [OR] =2.92, confidence interval [CI] 1.25–6.8, P = 0.01), breast conservation surgery (BCS) as opposed to mastectomy (OR = 4.78, CI 2.07–11.03, P < 0.001), having an anxiety disorder (OR = 2.4, CI 1.09–5.33, P = 0.03), and depression (OR = 3.08, CI 1.37–6.89, P < 0.01). On multivariate logistic regression, with stigma as the dependent variable, being less educated (adjusted OR [AOR] 3.08, CI 1.18–8.04, P = 0.02) and opting for BCS (AOR 6.12, CI 2.41–15.5, P < 0.001) were associated with higher stigma. Conclusions: Women with breast cancer should be screened for distress and stigma. Women opting for BCS may still have unmet emotional needs on completion of surgery and should have access to psychological interventions to address stigma, affective symptoms, and body image problems.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):146-152
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_74_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Detection and significance of human epidermal growth factor receptor 2
           expression in gastric adenocarcinoma

    • Authors: Sutapa Halder, Debjani Mallick, Priyanka Mondal, Debajyoti Singha Roy, Aniket Halder, Sudipta Chakrabarti
      Pages: 153 - 157
      Abstract: Sutapa Halder, Debjani Mallick, Priyanka Mondal, Debajyoti Singha Roy, Aniket Halder, Sudipta Chakrabarti
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):153-157
      Background: Human epidermal growth factor receptor 2 (HER2) is involved in the pathogenesis of several types of cancer, including gastric cancer. Overexpression of HER2 is noted in 10%–22.8% of gastric adenocarcinoma and its identification is of immense importance for management by targeted drugs. Detection of HER2 expression in gastric malignancies has not been undertaken previously in the local population. Objective: To ascertain HER2 immunohistochemical expression in gastric adenocarcinoma and its relationship with the anatomic location and histomorphology. Materials and Methods: A total of 47 cases of gastric adenocarcinoma diagnosed over 2 years constituted the study group. Clinical history, type of operation, gross morphology, and hematoxylin and eosin (H and E) stained sections were reviewed. Two paraffin blocks were selected, immunostain was performed using rabbit monoclonal HER2 antibody and Hoffmann scoring system was applied. Results: Most of gastric carcinomas occurred in male (42 cases), having a mean age of 53.6 years. A total of eight cases (17.1%) had expressed a score of 3+ HER2 positivity. All positivity was noted in intestinal type according to Lauren classification (25%) and none in diffuse type. All HER2 score of 3+ was noted in histological grade of well and moderately differentiated adenocarcinoma. Score 2+ was noted in seven cases, among them, only two were poorly differentiated gastric adenocarcinoma. Conclusion: HER2 overexpression was noticeably associated with an intestinal subtype, and well and moderately differentiated adenocarcinomas. Such cases of gastric adenocarcinoma are considered for targeted therapy with trastuzumab in the local population.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):153-157
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_159_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • A significant breakthrough in the incidence of childhood cancers and
           evaluation of its risk factors in Southern Iran

    • Authors: Asma Erjaee, Maryam Niknam, Ahmadreza Sadeghi, Maryam Dehghani, Zeinab Safaei, Saeed Hosseini Teshnizi, Mehran Karimi
      Pages: 158 - 164
      Abstract: Asma Erjaee, Maryam Niknam, Ahmadreza Sadeghi, Maryam Dehghani, Zeinab Safaei, Saeed Hosseini Teshnizi, Mehran Karimi
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):158-164
      Background and Objective: This study investigates epidemiologic and practical information about the incidence and risk factors of childhood cancer in a population of Southern Iranian children. Materials and Methods: A total number of 300 cancer patients along with 600 age- and gender-matched healthy control were interviewed by a trained physician regarding their demographic characteristics, and major family-associated risk factors, childhood malignancies. Results: The average annual percentage change for cancers in the studied population is calculated as 45%. Our study indicated that possible risk factors which could contribute to the development of childhood cancer are maternal oral contraceptive pill use during pregnancy, exposure to radiation during pregnancy, parental smoking, residence near high voltage electricity lines, exposure to pesticides and fertilizers, patient allergy, contact with domestic animals and father's educational degree. Furthermore, new ecological risk factors such as air pollution due to nonstandard petroleum or toxic inhalant particles, nonhealthy food consumption, and satellite jamming are other predisposing factors. Conclusion: Our study reported a higher average annual percentage change of childhood cancers in our area, compared to the existing literature. In conclusion, detection and prevention of the consistent and possible new environmental risk factors such as nonstandard petroleum or satellite jamming from all around the country should be taking into consideration.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):158-164
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_40_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Symptom burden and quality of life issues among patients of chronic
           myeloid leukemia on long-term imatinib therapy

    • Authors: Radhika Unnikrishnan, Surendran Veeraiah, Prasanth Ganesan
      Pages: 165 - 168
      Abstract: Radhika Unnikrishnan, Surendran Veeraiah, Prasanth Ganesan
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):165-168
      Background: Tyrosine kinase inhibitors such as imatinib have improved survival in chronic myeloid leukemia (CML). Imatinib can cause chronic side effects which are not considered serious but can impact the quality of life (QoL) of the patient. Methods: The results of a detailed symptom burden analysis and its impact on QoL scores in a cohort of patients on long-term imatinib is presented in this study. Symptom burden was assessed using the M. D. Anderson Symptom Inventory specific for CML patients. An indigenously developed QoL questionnaire (Cancer Institute Quality of Life II) was administered simultaneously. Results: Of 221 patients of CML (M:F = 133:88; median age: 39 years [18–65], median duration of imatinib: 4 years), QoL scores were high in 46%, average in 39%, and low in 14%. QoL scores were negatively correlated with general symptoms (r = −0.612, P < 0.001), CML-specific symptoms (r = −0.513, P < 0.001), and interference of symptoms (r = −0.596, P < 0.001). Conclusions: Significant impairment of QoL was noted among patients with CML primarily due to the burden of symptom related to side effects of imatinib. This issue must be addressed both in the clinic as well as in all studies of CML.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):165-168
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_160_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • The relationship between serum selenium and zinc with gastroesophageal
           cancers in the Southeast of Iran

    • Authors: Seyed Mehdi Hashemi, Mohamadali Mashhadi, Alireza Ansari Moghaddam, Javad Yousefi, Ahmad Dizangian Mofrad, Masoud Sadeghi, Abolghasem Allahyari
      Pages: 169 - 172
      Abstract: Seyed Mehdi Hashemi, Mohamadali Mashhadi, Alireza Ansari Moghaddam, Javad Yousefi, Ahmad Dizangian Mofrad, Masoud Sadeghi, Abolghasem Allahyari
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):169-172
      Background: Selenium (Se) and zinc (Zn) have antioxidant and anticancer properties. Objective: The aim of this study was to evaluate the serum levels of Se and Zn and the correlation between the levels of these two elements with risk of incidence of esophageal cancer (EC) and gastric cancer (GC). Materials and Methods: In a case–control study, we selected sixty patients with GC or EC as the intervention group and 120 age-matched individuals as the control group. Exclusion criteria were the individuals with kidney and liver failure and the consumer of dietary supplements such as Se and Zn. Measurement of serum Se was done in a graphite furnace system and atomic absorption device of Varian and of serum Zn was done by a flame photometer system (flame) and atomic absorption device of Varian. Results: In thirty patients of ECs, 90% were squamous cell carcinoma and 10% adenocarcinoma, and out of thirty patients of GCs, 90% were intestinal type and 10% diffuse type. The level of two elements in cancer patients was lower than the control group (P < 0.05). There was no significant different between two cancer groups for level of Se and Zn, but there was a significant difference between the control group with two other groups. Conclusion: Our study confirmed the findings from previous prospective studies and randomized trials that reducing of lower levels of Se and Zn can effect on incidence of cancer.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):169-172
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_83_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Metastatic ewing's sarcoma: Revisiting the “Evidence on the
           Fence”

    • Authors: Nehal Khanna, Avinash Pandey, Jyoti Bajpai
      Pages: 173 - 181
      Abstract: Nehal Khanna, Avinash Pandey, Jyoti Bajpai
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):173-181
      Metastatic Ewing's sarcoma is a challenging disease for oncology care providers with wide spectrum of disease at presentation, widely varying approach to the treatment and varied outcomes. The paucity of randomized evidence is a barrier in developing a consensus. This perspective provides the evidence ”for and against” the benefit of aggressive approach including local and systemic therapy in patients presenting with metastatic Ewing's sarcoma and provide general recommendations so as to help select patients who will benefit with definitive intent treatment and also, avoid aggressive approach in patients with dismal outcome.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):173-181
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_24_17
      Issue No: Vol. 38, No. 2 (2017)
       
  • Immune checkpoint blockers and ovarian cancer

    • Authors: Chinmoy K Bose
      Pages: 182 - 189
      Abstract: Chinmoy K Bose
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):182-189
      Although the idea, called “cancer immunotherapy,” is very appealing and has previously been shown to work in several mouse models of cancer, it has in general been very difficult to translate cancer immunotherapy approaches to humans. Because of this frustration, by the 1990s, many scientists and biotechnology companies had given up on the idea of cancer immunotherapy. After few years, first detection T-cell suppression of effect of cytotoxic T-lymphocyte antigen-4 (CTLA4) molecule was established. Antibody (Ab) to CTLA4 could increase T-cell starting a completely new age of tumor immunology. Immune checkpoints are new ways in manipulation of immunological control over malignant tumors. It has lent an important measure to manage, especially recurrent and refractory cancers and those cancer where there is an unmet need like recurrent melanoma, renal cell carcinoma, and recurrent ovarian cancer. As a new development, this subject is experiencing rapid progress, and multiple avenues are opening up. Although there are many hurdles to overcome this needs constant updating, especially for students of ovarian cancer who are looking at it with much hope.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):182-189
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_73_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Cytotoxic drug dispersal, cytotoxic safety, and cytotoxic waste
           management: Practices and proposed India-specific guidelines

    • Authors: Malini R Capoor, Kumar Tapas Bhowmik
      Pages: 190 - 197
      Abstract: Malini R Capoor, Kumar Tapas Bhowmik
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):190-197
      This article deals with practices related to cytotoxic drug dispersal, cytotoxic safety, and cytotoxic waste management and attempts at India-specific guidelines for their dispersal and disposal. The articles related to cytotoxic drug dispersal, cytotoxic safety, and cytotoxic waste management were reviewed from PubMed and their applicability in Indian health-care facilities (HCFs) was also reviewed. All HCFs dealing with cytotoxic drugs should consider cytotoxic policy, patient safety and health-care worker safety, and environmental monitoring program as per the available international guidelines customized as per Indian conditions. Utmost care in handling cytotoxic waste is quintessential. The formation of India-specific cytotoxic guidelines requires the inputs from all stakeholders. Cytotoxic waste, cytotoxic safety, and cytotoxic waste management should be the subject of a national strategy with an infrastructure, cradle-to-grave legislation, competent regulatory authority, and trained personnel.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):190-197
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_174_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Role of insulin-like growth factor, insulin-like growth factor receptors,
           and insulin-like growth factor-binding proteins in ovarian cancer

    • Authors: Periyasamy Amutha, Thangarajan Rajkumar
      Pages: 198 - 206
      Abstract: Periyasamy Amutha, Thangarajan Rajkumar
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):198-206
      Insulin and IGFs play an important role in cancer initiation and progression, including ovarian cancer (OC). Epithelial ovarian cancer (EOC) is the most frequent type of OC in women and it is the most lethal gynecological malignancy worldwide. Generally, insulin is associated with metabolism, whereas Insulin like growth factors (IGFs) are involved in cell proliferation. Hence, Insulin-like growth factor binding proteins (IGFBPs) determines the bioavailability of IGFs in circulation. The interplay between these molecules such as insulin, IGFs, IGFBPs and insulin-like growth factor receptor 1 (IGF1R) may be crucial for ovarian cancer cell biology and cancer progression. However, the IGF1R inhibitors exhibiting potent activity on IGF/IGF1R also demonstrated activity against OC cells. The combination therapy of drugs may prove to be beneficial in clinical management of OC. This review describes both molecular and clinical associations between insulin and IGF1 signaling pathways in ovarian cancer. The data was collected using PubMed search engine with the following key words such as ovarian cancer, IGFs, IGFBP, IGF1Rs and ovarian cancer.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):198-206
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_3_17
      Issue No: Vol. 38, No. 2 (2017)
       
  • Solid pseudopapillary tumor of pancreas: A case report and review of
           literature

    • Authors: Gursev Sandlas, Charu Tiwari
      Pages: 207 - 209
      Abstract: Gursev Sandlas, Charu Tiwari
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):207-209
      Solid pseudopapillary neoplasm of the pancreas is one of the rarest forms of pancreatic neoplasm. It was also known as Franz's tumor or Hamoudi tumor until WHO labeled it as solid pseudopapillary tumor (SPT) in 1996. It typically affects young non-Caucasian females in their second or third decade of life. Treatment involves complete excision of the tumor which results in complete cure in majority of the cases. We present here a report of 11-year-old girl with SPT and also do a review of literature for this rare tumor.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):207-209
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_59_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • A case of mature cystic teratoma in an 8-year-old girl: A rare case report

    • Authors: Manika Agarwal, Shweta Mishra
      Pages: 210 - 211
      Abstract: Manika Agarwal, Shweta Mishra
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):210-211
      Ovarian tumors are commonly seen in reproductive age group in women. However, when they occur at extremes of age, the suspicion of malignancy increases. The detection of dermoid cyst at 8 years of age is uncommon and hence is being reported to acquaint the doctors of this possibility. Awareness of benign tumors in small children can help in proper counseling of patient party and planning the surgical procedure.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):210-211
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_109_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Ruptured malignant ovarian tumor in an adolescent girl: A rare case report

    • Authors: Kanika Chopra, Swati Agrawal, Kiran Aggarwal, Ratna Biswas
      Pages: 212 - 214
      Abstract: Kanika Chopra, Swati Agrawal, Kiran Aggarwal, Ratna Biswas
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):212-214
      Germ cell tumors which arise mainly in pediatric and adolescent age group, account for 30% of all ovarian tumors, but constitute only 5% of all malignant ovarian tumors. The presentation is usually insidious with the patient presenting with abdominal swelling and dull aching pain. We report a rare case of a malignant germ cell tumor in a 12-year-old girl who presented with acute abdomen due to spontaneous rupture of tumor resulting in hemoperitoneum. The patient was taken up for emergency laparotomy and left salpingo-opherectomy with omentectomy and drainage of hemoperitoneum was done. The authors conclude that ruptured malignant ovarian tumor should be considered in the differential diagnosis of any young girl presenting with abdominal mass and acute abdominal pain.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):212-214
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_2_17
      Issue No: Vol. 38, No. 2 (2017)
       
  • Massive hemoptysis: A rare presentation of anterior mediastinal teratoma
           in an adolescent

    • Authors: Rajkumar M Meshram, S Abhisheik, Vaidehi Hardas, K Siddharth
      Pages: 215 - 217
      Abstract: Rajkumar M Meshram, S Abhisheik, Vaidehi Hardas, K Siddharth
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):215-217
      Germ cell tumors are predominantly found in the gonads, and the most common extragonadal site is anterior mediastinum. Usual symptoms are cough, dyspnea, and fever, chest pain due to mass effect or intrapulmonary invasion but hemoptysis is rare and may result from either communication with tracheobronchial tree or may result from bronchial bleeding due to irritation by tumor. As in our case, patient presenting with massive hemoptysis and shock are the rarest presentation of a benign teratoma.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):215-217
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_62_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Rhabdoid meningioma of brain - a rare aggressive tumor

    • Authors: Sajeeb Mondal, Rajashree Pradhan, Subrata Pal, Sharmistha Chatterjee, Arindam Bandyapadhyay, Debosmita Bhattacharyya
      Pages: 218 - 219
      Abstract: Sajeeb Mondal, Rajashree Pradhan, Subrata Pal, Sharmistha Chatterjee, Arindam Bandyapadhyay, Debosmita Bhattacharyya
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):218-219
      Rhabdoid meningioma is a rare aggressive variant of meningioma, regarded as WHO Grade III type. Histologically and cytologically, it is distinctive type having abundant eosinophilic cytoplasm, cytoplasmic inclusion with eccentrically placed vesicular nuclei and prominent nucleoli. High recurrence rate and poor outcome are important features. Here, we are presenting a rare case of rhabdoid meningioma found in a recurrent meningioma of the posterior fossa in a middle-aged female. We emphasized the squash cytology and histology finding of the rare neoplasm.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):218-219
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_87_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Prosthetic management of hard palate perforation in a child with acute
           lymphoblastic leukemia

    • Authors: Gunjan C Chouksey, Kanchan P Dholam
      Pages: 220 - 222
      Abstract: Gunjan C Chouksey, Kanchan P Dholam
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):220-222
      Palatal perforation is an uncommon complication seen in children with acute lymphoblastic leukemia undergoing chemotherapy. This may impact basic functions, such as speech, swallowing, chewing, affecting the quality of life (QOL). Prosthetic rehabilitation of the palatal perforation with obturator can optimally restore function, thereby improving and enhancing the QOL of these patients.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):220-222
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_17_17
      Issue No: Vol. 38, No. 2 (2017)
       
  • Mammary myofibroblastoma with unusual morphological and
           immunohistochemical features

    • Authors: Ons Boudaouara, Chiraz Chaari, Abdelkhalek Hassini, Tahya Sellami Boudaouara
      Pages: 223 - 225
      Abstract: Ons Boudaouara, Chiraz Chaari, Abdelkhalek Hassini, Tahya Sellami Boudaouara
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):223-225
      Mammary myofibroblastoma (MFB) is a rare mesenchymal tumor, derived from mammary stromal fibro/myofibroblasts, which has various morphological features and characteristic immunohistochemical staining. The epithelioid morphologic variant is defined, accordingly, as a proliferation of exclusively or predominantly (>50%) epithelioid cells, variably embedded in a myxoid to fibrous stroma. These histological and cytological features may pose a diagnostic challenge mainly with metaplastic carcinoma and invasive lobular carcinoma of the breast. Thus, immunohistochemical staining by myofibroblastic markers is helpful for confirming diagnosis. Herein, we present a case of MFB in a 43-year-old female. This case report emphasizes the role of immunohistochemistry as gold standard in the diagnosis of MFB. This case is also being presented because of its unusual radiologic findings, its epithelioid histologic variant mimicking malignancy, and its uncommon immunohistochemical phenotype.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):223-225
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_115_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Bulky pelvic hodgkin lymphoma in a prepubertal girl

    • Authors: Sidharth Totadri, Deepak Bansal, Amanjit Bal, Prema Menon
      Pages: 226 - 227
      Abstract: Sidharth Totadri, Deepak Bansal, Amanjit Bal, Prema Menon
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):226-227
      Pure infra-diaphragmatic presentation is rare in pediatric Hodgkin lymphoma (HL). Isolated pelvic presentation is restricted to case reports in adults. We describe a unique presentation of HL as a primary pelvic disease in an 11-year-old prepubertal girl. She was treated based on the Euronet-Paediatric Hodgkin's Lymphoma Group protocol (EuroNet-PHL-C1) recommendations and assigned to treatment Group 2 (Stage IIB). The patient had bulky disease and a suboptimal response on interim 18-fluorodeoxyglucose positron emission tomography. The child was administered chemotherapy alone. Pelvic radiotherapy was consciously avoided due to the high risk of gonadal failure. She remains disease-free for 18 months now. Treatment of pediatric HL necessitates a delicate balance between achieving cure as well as avoiding serious late effects of therapy.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):226-227
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_150_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Metastatic primary angiosarcoma of the breast: Can we tame it the
           metronomic way

    • Authors: Raja Pramanik, Ajay Gogia, Prabhat Singh Malik, Ramana Gogi
      Pages: 228 - 231
      Abstract: Raja Pramanik, Ajay Gogia, Prabhat Singh Malik, Ramana Gogi
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):228-231
      Primary angiosarcoma of the breast is a highly aggressive but rare malignant neoplasm. Palliative chemotherapy with different agents and combinations has been tried in the metastatic setting with poor results. We present the case of a young woman with this disease describing her aggressive course. We used a metronomic combination of oral drugs due to her poor general condition and achieved disease stabilization although not durable.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):228-231
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_156_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Primary intraosseous malignant peripheral nerve sheath tumor of metacarpal
           bones of the hand in a patient without neurofibromatosis 1: Report of a
           rare case

    • Authors: Bharti Devnani, Ahitagni Biswas, Sameer Bakhshi, Shah Alam Khan, Asit Ranjan Mridha, Shipra Agarwal
      Pages: 232 - 235
      Abstract: Bharti Devnani, Ahitagni Biswas, Sameer Bakhshi, Shah Alam Khan, Asit Ranjan Mridha, Shipra Agarwal
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):232-235
      Malignant peripheral nerve sheath tumor (MPNST) usually arises in peripheral nerve sheath cells. The intraosseous location of MPNST is rare. Mandible is the most common site of bony involvement. Involvement of bones of the hand is quite unusual. We report a case of MPNST involving metacarpal bones of the left hand treated with surgery followed by adjuvant radiation and chemotherapy and review the pertinent literature.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):232-235
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_5_17
      Issue No: Vol. 38, No. 2 (2017)
       
  • Hepatic amyloidosis: Something that can camouflage and deceive our
           perception!

    • Authors: Anirudh V Nair, Manish Kumar Yadav, Madhavan N Unni, CM Simi, KA Biji, KS Manoj, Shabeer Ali, Ajith K Nair
      Pages: 236 - 239
      Abstract: Anirudh V Nair, Manish Kumar Yadav, Madhavan N Unni, CM Simi, KA Biji, KS Manoj, Shabeer Ali, Ajith K Nair
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):236-239
      Amyloidosis is a multi-systemic diffusely infiltrating disease due to extracellular deposition of protein-mucopolysaccharide complexes. The type of protein deposited determines the subgroup of amyloid. Hepatic amyloidosis is a rare infiltrating disease affecting the hepatic parenchyma. A wide range of clinical presentation and atypical imaging findings delay the diagnosis of amyloidosis, while tissue biopsy demonstrating amyloid deposits is vital for a definitive diagnosis.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):236-239
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_46_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Incidence and pattern of childhood cancers in India: Findings from
           population-based cancer registries

    • Authors: MD Abu Bashar, JS Thakur
      Pages: 240 - 241
      Abstract: MD Abu Bashar, JS Thakur
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):240-241
      Childhood cancers have different characteristics than those occurring among adults and described as cancers occurring below 15 years of age. In developed countries, its incidence is relatively rare but it's a leading cause of death. More than 80% of the childhood cancers are occurring in low and middle income countries. Based on data from population based cancer registries under National Cancer Registry Programme, in this commentary, we described the incidence and pattern of Childhood cancers in India and its implications.
      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):240-241
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_163_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Two cases of acinic cell carcinoma of parotid gland – Rare papillary
           cystic variant: One unusual presentation in older male patient

    • Authors: Mitul Modi, Tarang Patel, Priti Trivedi
      Pages: 242 - 244
      Abstract: Mitul Modi, Tarang Patel, Priti Trivedi
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):242-244

      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):242-244
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_39_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Primary diffuse large B-cell lymphoma of the breast: A rare case and
           review of literature

    • Authors: Dhruv Pankaj Mehta, Pushpak Chirmade, Asha S Anand, Sonia Parikh
      Pages: 244 - 247
      Abstract: Dhruv Pankaj Mehta, Pushpak Chirmade, Asha S Anand, Sonia Parikh
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):244-247

      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):244-247
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_112_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Alternative ketogenic diet with coconut milk in a case with underlying
           colorectal cancer

    • Authors: Kamon Chaiyasit, Kanin Tripipitsiriwat, Kusuma Srikaew, Viroj Wiwanitkit
      Pages: 247 - 248
      Abstract: Kamon Chaiyasit, Kanin Tripipitsiriwat, Kusuma Srikaew, Viroj Wiwanitkit
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):247-248

      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):247-248
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_47_16
      Issue No: Vol. 38, No. 2 (2017)
       
  • Toxoplasmosis and lymphoma: The mimickers

    • Authors: Mansoor C Abdulla, Hazwa K Hamza
      Pages: 248 - 250
      Abstract: Mansoor C Abdulla, Hazwa K Hamza
      Indian Journal of Medical and Paediatric Oncology 2017 38(2):248-250

      Citation: Indian Journal of Medical and Paediatric Oncology 2017 38(2):248-250
      PubDate: Thu,10 Aug 2017
      DOI: 10.4103/ijmpo.ijmpo_155_16
      Issue No: Vol. 38, No. 2 (2017)
       
 
 
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