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Publisher: Medknow Publishers   (Total: 426 journals)

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Showing 1 - 200 of 426 Journals sorted alphabetically
Acta Medica Intl.     Open Access   (SJR: 0.101, CiteScore: 0)
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advanced Biomedical Research     Open Access  
Advances in Human Biology     Open Access   (Followers: 4)
Advances in Skeletal Muscle Function Assessment     Open Access  
African J. for Infertility and Assisted Conception     Open Access  
African J. of Medical and Health Sciences     Open Access   (Followers: 3)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.25, CiteScore: 1)
African J. of Trauma     Open Access   (Followers: 1)
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access   (Followers: 2)
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Alexandria J. of Pediatrics     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 5)
Anesthesia : Essays and Researches     Open Access   (Followers: 10)
Annals of African Medicine     Open Access   (Followers: 2, SJR: 0.258, CiteScore: 1)
Annals of Bioanthropology     Open Access   (Followers: 4)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.308, CiteScore: 1)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery     Open Access  
Annals of Indian Psychiatry     Open Access  
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 12, SJR: 0.352, CiteScore: 1)
Annals of Saudi Medicine     Open Access   (SJR: 0.238, CiteScore: 1)
Annals of Thoracic Medicine     Open Access   (Followers: 6, SJR: 0.524, CiteScore: 1)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 13, SJR: 0.152, CiteScore: 0)
Annals of Tropical Pathology     Open Access  
Apollo Medicine     Open Access  
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access   (Followers: 1)
Archives of Cardiovascular Imaging     Open Access   (Followers: 2, SJR: 0.187, CiteScore: 0)
Archives of Intl. Surgery     Open Access   (Followers: 10, SJR: 0.302, CiteScore: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Medicine and Surgery     Open Access  
Archives of Pharmacy Practice     Open Access   (Followers: 10, SJR: 0.102, CiteScore: 0)
Archives of Trauma Research     Open Access   (Followers: 3, SJR: 0.37, CiteScore: 2)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 5)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.856, CiteScore: 2)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 2)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.35, CiteScore: 1)
Asian Pacific J. of Reproduction     Open Access   (SJR: 0.227, CiteScore: 1)
Asian Pacific J. of Tropical Biomedicine     Open Access   (Followers: 2, SJR: 0.491, CiteScore: 2)
Asian Pacific J. of Tropical Medicine     Open Access   (Followers: 1, SJR: 0.561, CiteScore: 2)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
Biomedical and Biotechnology Research J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access   (Followers: 1)
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Canadian J. of Rural Medicine     Full-text available via subscription   (SJR: 0.202, CiteScore: 0)
Cancer Translational Medicine     Open Access   (Followers: 2)
Cardiology Plus     Open Access   (Followers: 1)
Chinese Medical J.     Open Access   (Followers: 10, SJR: 0.52, CiteScore: 1)
CHRISMED J. of Health and Research     Open Access   (Followers: 2)
Clinical Cancer Investigation J.     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 4)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 9, SJR: 0.811, CiteScore: 2)
Contemporary Clinical Dentistry     Open Access   (Followers: 4, SJR: 0.353, CiteScore: 1)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.543, CiteScore: 1)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 4, SJR: 0.152, CiteScore: 0)
Dental Research J.     Open Access   (Followers: 12, SJR: 0.416, CiteScore: 1)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 6, SJR: 0.242, CiteScore: 0)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1, SJR: 1.799, CiteScore: 2)
Egyptian J. of Chest Diseases and Tuberculosis     Open Access   (Followers: 3, SJR: 0.155, CiteScore: 0)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Nursing J.     Open Access  
Egyptian Orthopaedic J.     Open Access   (Followers: 2)
Egyptian Pharmaceutical J.     Open Access   (Followers: 3)
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access   (Followers: 2)
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.822, CiteScore: 2)
Environmental Disease     Open Access   (Followers: 3)
Eurasian J. of Pulmonology     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.749, CiteScore: 2)
European J. of General Dentistry     Open Access   (Followers: 1, SJR: 0.12, CiteScore: 0)
European J. of Prosthodontics     Open Access   (Followers: 3)
European J. of Psychology and Educational Studies     Open Access   (Followers: 11, SJR: 0.113, CiteScore: 0)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.112, CiteScore: 0)
Genome Integrity     Open Access   (Followers: 2, SJR: 0.153, CiteScore: 0)
Glioma     Open Access  
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Gynecology and Minimally Invasive Therapy     Open Access   (SJR: 0.311, CiteScore: 1)
Hamdan Medical J.     Open Access  
Heart and Mind     Open Access  
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
Ibnosina J. of Medicine and Biomedical Sciences     Open Access  
IJS Short Reports     Open Access  
Imam J. of Applied Sciences     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.478, CiteScore: 1)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (Followers: 1, SJR: 0.361, CiteScore: 1)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.37, CiteScore: 1)
Indian J. of Dental Research     Open Access   (Followers: 5, SJR: 0.266, CiteScore: 1)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.468, CiteScore: 1)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 4, SJR: 0.445, CiteScore: 1)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1, SJR: 0.791, CiteScore: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4, SJR: 0.568, CiteScore: 1)
Indian J. of Health Sciences and Biomedical Research KLEU     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.425, CiteScore: 1)
Indian J. of Medical Microbiology     Open Access   (Followers: 2, SJR: 0.503, CiteScore: 1)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.656, CiteScore: 1)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.102, CiteScore: 0)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.347, CiteScore: 1)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.23, CiteScore: 0)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 3, SJR: 0.225, CiteScore: 1)
Indian J. of Ophthalmology     Open Access   (Followers: 4, SJR: 0.498, CiteScore: 1)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 8, SJR: 0.392, CiteScore: 1)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.199, CiteScore: 0)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 2)
Indian J. of Palliative Care     Open Access   (Followers: 6, SJR: 0.454, CiteScore: 1)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 3, SJR: 0.276, CiteScore: 1)
Indian J. of Pharmacology     Open Access   (SJR: 0.412, CiteScore: 1)
Indian J. of Plastic Surgery     Open Access   (Followers: 13, SJR: 0.311, CiteScore: 0)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.408, CiteScore: 1)
Indian J. of Psychological Medicine     Open Access   (SJR: 0.368, CiteScore: 1)
Indian J. of Public Health     Open Access   (Followers: 1)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Respiratory Care     Open Access  
Indian J. of Rheumatology     Open Access   (Followers: 1, SJR: 0.119, CiteScore: 0)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.34, CiteScore: 0)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Transplantation     Open Access  
Indian J. of Urology     Open Access   (Followers: 4, SJR: 0.434, CiteScore: 1)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Indian Spine J.     Open Access  
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intervention     Open Access   (Followers: 1)
Intl. Archives of Health Sciences     Open Access  
Intl. J. of Abdominal Wall and Hernia Surgery     Open Access   (Followers: 1)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Clinicopathological Correlation     Open Access   (Followers: 1)
Intl. J. of Community Dentistry     Open Access  
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1, SJR: 0.192, CiteScore: 0)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 5, SJR: 0.142, CiteScore: 0)
Intl. J. of Growth Factors and Stem Cells in Dentistry     Open Access  
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 6)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.535, CiteScore: 1)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4, SJR: 0.17, CiteScore: 0)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 3)
Intl. J. of Orofacial Biology     Open Access   (Followers: 1)
Intl. J. of Orofacial Research     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access   (Followers: 1)
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 2)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.623, CiteScore: 1)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 5, SJR: 0.653, CiteScore: 1)
Intl. J. of the Cardiovascular Academy     Open Access   (SJR: 0.105, CiteScore: 0)
Intl. J. of Trichology     Open Access   (SJR: 0.4, CiteScore: 1)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 3)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  

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Indian Journal of Medical Sciences
Journal Prestige (SJR): 0.102
Number of Followers: 2  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0019-5359 - ISSN (Online) 0019-5359
Published by Medknow Publishers Homepage  [426 journals]
  • World Hypertension Day: Contemporary issues faced in India

    • Authors: Arun Pulikkottil Jose, Dorairaj Prabhakaran
      Pages: 567 - 570
      Abstract: Arun Pulikkottil Jose, Dorairaj Prabhakaran
      Indian Journal of Medical Research 2019 149(5):567-570

      Citation: Indian Journal of Medical Research 2019 149(5):567-570
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_549_19
      Issue No: Vol. 149, No. 5 (2019)
       
  • Subcutaneous adipose tissue & visceral adipose tissue

    • Authors: Balraj Mittal
      Pages: 571 - 573
      Abstract: Balraj Mittal
      Indian Journal of Medical Research 2019 149(5):571-573

      Citation: Indian Journal of Medical Research 2019 149(5):571-573
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_1910_18
      Issue No: Vol. 149, No. 5 (2019)
       
  • White Paper on Electronic Nicotine Delivery System

    • Authors: Indian Council of Medical Research
      Pages: 574 - 583
      Abstract: Indian Council of Medical Research
      Indian Journal of Medical Research 2019 149(5):574-583

      Citation: Indian Journal of Medical Research 2019 149(5):574-583
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_957_19
      Issue No: Vol. 149, No. 5 (2019)
       
  • Need for alternatives to animals in experimentation: An Indian perspective

    • Authors: Soumya Swaminathan, Vijay Kumar, Rajni Kaul
      Pages: 584 - 592
      Abstract: Soumya Swaminathan, Vijay Kumar, Rajni Kaul
      Indian Journal of Medical Research 2019 149(5):584-592

      Citation: Indian Journal of Medical Research 2019 149(5):584-592
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_2047_17
      Issue No: Vol. 149, No. 5 (2019)
       
  • Jagdish Chandra Bose & plant neurobiology

    • Authors: Prakash Narain Tandon
      Pages: 593 - 599
      Abstract: Prakash Narain Tandon
      Indian Journal of Medical Research 2019 149(5):593-599
      When Jagdish Chandra Bose, a renowned physicist, devoted himself entirely to research in the field of plant physiology post his superannuation at Presidency University, Kolkata, India (earlier known as Presidency College, Calcutta), it came as a surprise to many. The research on plant nervous system by JC Bose during this period was pioneering in nature, being recognized by recent plant biologists globally as the first in the field. His findings were so revolutionary at the time of their proclamation that these aroused disbelief and contradiction. Surprisingly, not many at that time took up such investigations and once accepted with reluctance, there was practically very little activity in the field for the next several decades. More than a hundred years later, recent advances in molecular biology, genomics, ecology and neurophysiology have led to renewed interest resulting in a flurry of activity, confirming most of Bose's observations. The present review describes this pioneering scientist's work and his immense contribution in the emergence of the discipline now designated as ‘Plant Neurobiology’.
      Citation: Indian Journal of Medical Research 2019 149(5):593-599
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_392_19
      Issue No: Vol. 149, No. 5 (2019)
       
  • Paediatric chronic myeloid leukaemia: Is it really a different
           disease?

    • Authors: Deepam Pushpam, Sameer Bakhshi
      Pages: 600 - 609
      Abstract: Deepam Pushpam, Sameer Bakhshi
      Indian Journal of Medical Research 2019 149(5):600-609
      Paediatric chronic myeloid leukaemia (CML) has biological and clinical differences from adult CML. Management of paediatric CML presents unique challenges in growing children, and there are no specific guidelines for paediatric CML. This review focusses on the clinical characteristics, diagnostic issues and management of paediatric CML. Major studies that provide the basis of managing paediatric CML are summerized here. Studies conducted on adult CML patients were used to guide the management of places where studies were lacking in paediatric CML. Recently, dasatinib and nilotinib have been approved for treatment of paediatric CML, and their role has been discussed in the current management perspective. Allogeneic transplant, fertility and vaccination in paediatric CML, have also been discussed.
      Citation: Indian Journal of Medical Research 2019 149(5):600-609
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_331_19
      Issue No: Vol. 149, No. 5 (2019)
       
  • ‘Obesageing’: Linking obesity &
           ageing

    • Authors: Shampa Ghosh, Jitendra Kumar Sinha, Manchala Raghunath
      Pages: 610 - 615
      Abstract: Shampa Ghosh, Jitendra Kumar Sinha, Manchala Raghunath
      Indian Journal of Medical Research 2019 149(5):610-615
      Obesity is one of the leading causes of preventable mortalities in many parts of the globe. The rise in geriatric population due to better treatment opportunities has also emerged as a major public health challenge. Both of these health challenges have impacted developed as well as developing countries. Obesity is attributed as a powerful risk factor of a variety of health problems such as cardiovascular diseases, hypertension, type 2 diabetes, dementia, neuropsychiatric diseases and many more. On the other hand, ageing is a natural process involving a gradual decline in physiological functions and is associated with similar co-morbidities as obesity. This review discusses about the commonalities (termed as ‘Obesageing') between the pathological phenomenon of obesity and normal physiological process of ageing. A unique rodent model of obesageing has been developed (WNIN/Ob) that has characteristics of morbid obesity as well as premature ageing. Such a novel animal model would facilitate the understanding of the complex interplay of different mechanisms that are common to obesity and ageing and help to devise strategies in future to tackle the growing burden of obesity and ageing.
      Citation: Indian Journal of Medical Research 2019 149(5):610-615
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_2120_18
      Issue No: Vol. 149, No. 5 (2019)
       
  • Different gene expression profiles in subcutaneous & visceral adipose
           tissues from Mexican patients with obesity

    • Authors: María D Ronquillo, Alla Mellnyk, Noemí Cárdenas-Rodríguez, Emmanuel Martínez, David A Comoto, Liliana Carmona-Aparicio, Norma E Herrera, Eleazar Lara, Armando Pereyra, Esaú Floriano-Sánchez
      Pages: 616 - 626
      Abstract: María D Ronquillo, Alla Mellnyk, Noemí Cárdenas-Rodríguez, Emmanuel Martínez, David A Comoto, Liliana Carmona-Aparicio, Norma E Herrera, Eleazar Lara, Armando Pereyra, Esaú Floriano-Sánchez
      Indian Journal of Medical Research 2019 149(5):616-626
      Background & objectives: Obesity is a health problem that requires substantial efforts to understand the physiopathology of its various types and to determine therapeutic strategies for its treatment. The objective of this study was to characterize differences in the global gene expression profiles of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) between control patients (normal weight) and patients with obesity (IMC≥30) using microarrays.Methods: Employing RNA isolated from SAT and VAT samples obtained from eight control and eight class I, II and III patients with obesity, the gene expression profiles were compared between SAT and VAT using microarrays and the findings were validated via real-time quantitative polymerase chain reaction.Results: A total of 327 and 488 genes were found to be differentially expressed in SAT and VAT, respectively (P≤0.05). Upregulation of PPAP2C, CYP4A11 and CYP17A1 genes was seen in the VAT of obese individuals.Interpretation & conclusions: SAT and VAT exhibited significant differences in terms of the expression of specific genes. These genes might be related to obesity. These findings may be used to improve the clinical diagnosis of obesity and could be a tool leading to the proposal of new therapeutic strategies for the treatment of obesity.
      Citation: Indian Journal of Medical Research 2019 149(5):616-626
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_1165_17
      Issue No: Vol. 149, No. 5 (2019)
       
  • Apoptosis gene reprograming of human peripheral blood mononuclear cells
           induced by radioiodine-131 (131I) irradiation

    • Authors: Jian-Fang Li, Liang-Jun Xie, Lu-Ping Qin, Yi-Fei Liu, Ting-Jie Zhang, Yong Huang, Mu-Hua Cheng
      Pages: 627 - 632
      Abstract: Jian-Fang Li, Liang-Jun Xie, Lu-Ping Qin, Yi-Fei Liu, Ting-Jie Zhang, Yong Huang, Mu-Hua Cheng
      Indian Journal of Medical Research 2019 149(5):627-632
      Background & objectives: The nature of adaptable change of B-cell lymphoma-2 (BCL-2) and/or Bcl2-associated X protein (BAX) gene expression in the human peripheral blood mononuclear cells (PBMCs) irradiated by radioiodine in thyroid diseases therapy is not fully understood. In this study, the alternation of apoptotic gene expression was evaluated while the PBMCs collected from healthy volunteers were irradiated by the radioiodine-131 (131I).Methods: Fasting blood samples were obtained from healthy volunteers. PBMCs from group 0 to 6 were incubated and exposed to different doses of 131I in cell suspension for 6, 12, 24 and 48 h. The apoptosis rates and expression of BCL-2 and BAX genes of PBMCs were examined.Results: The apoptosis rate in the human PBMCs was gradually enhanced after six hour irradiation. The values of BCL-2 and BAX gene expression in groups 1-6 were higher than in group 0 within 6 h of irradiation, and then, these were decreased gradually from 6 to 12 h. BCL-2 gene expression increased in groups 1-3 after 12 h irradiation, but there was no difference in groups 4-6. The ratio of BCL-2/BAX gene expression among groups 4-6 gradually decreased during the period from 6 to 12 h, and it was significantly lower than in the group 0 at 12, 24 and 48 h.Interpretation & conclusions: The expression of BCL-2 and BAX genes was initially upregulated following irradiation. Later, the balance of BCL-2/BAX genes expression was adjusted, and then, PBMCs underwent apoptosis at higher doses of radiation.
      Citation: Indian Journal of Medical Research 2019 149(5):627-632
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_1455_17
      Issue No: Vol. 149, No. 5 (2019)
       
  • Initial trends of individual donation nucleic acid testing in voluntary
           & replacement donors from a tertiary care centre in north India

    • Authors: Rekha Hans, Neelam Marwaha, Suresh Sharma, Suchet Sachdev, Ratti Ram Sharma
      Pages: 633 - 640
      Abstract: Rekha Hans, Neelam Marwaha, Suresh Sharma, Suchet Sachdev, Ratti Ram Sharma
      Indian Journal of Medical Research 2019 149(5):633-640
      Background & objectives: Individual donation nucleic acid testing (ID-NAT) is considered as sensitive technology to assess blood safety from viral transfusion-transmissible infections (TTIs) in blood donors. The present study was aimed to analyze the results of ID-NAT for three years (2013-2015) with special reference to different types of donors and their age ranges in a tertiary care centre in north India.Methods: The results of ID-NAT for three years were retrospectively analyzed at our centre. A total of 168,433 donations were tested with ID-NAT, of which 10,467 were tested with Procleix® Ultrio® reagents and 157,966 were tested with Procleix®UltrioPlus® reagents, and the results were compared with those of serology to calculate the NAT yield in voluntary, replacement, first-time and repeat donors.Results: A combined NAT yield was observed as one in 1031 out of 167,069 seronegative donations with HBV yield as one in 1465, HCV yield as one in 3885 and HIV-1 as one in 167,069. Yield for co-infection (HCV and HBV) was one in 41,767. A high NAT yield was observed in replacement donors (1 in 498) as compared to voluntary donors (1 in 1320).Interpretation & conclusions: Addition of NAT to serology improved the blood safety in our centre interdicting possibility of 150 TTIs annually. It has also reemphasized the safety of voluntary over replacement donors. The results also highlight the need of proper counselling, notification and referral guidelines of NAT yield donors in our country and other countries which lack them.
      Citation: Indian Journal of Medical Research 2019 149(5):633-640
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_822_17
      Issue No: Vol. 149, No. 5 (2019)
       
  • Effect of cell density on formation of three-dimensional cartilaginous
           constructs using fibrin & human osteoarthritic chondrocytes

    • Authors: BS Shamsul, Shiplu Roy Chowdhury, MY Hamdan, B. H. I. Ruszymah
      Pages: 641 - 649
      Abstract: BS Shamsul, Shiplu Roy Chowdhury, MY Hamdan, B. H. I. Ruszymah
      Indian Journal of Medical Research 2019 149(5):641-649
      Background & objectives: Seeding density is one of the major parameters affecting the quality of tissue-engineered cartilage. The objective of this study was to evaluate different seeding densities of osteoarthritis chondrocytes (OACs) to obtain the highest quality cartilage.Methods: The OACs were expanded from passage 0 (P0) to P3, and cells in each passage were analyzed for gross morphology, growth rate, RNA expression and immunochemistry (IHC). The harvested OACs were assigned into two groups: low (1×10[7] cells/ml) and high (3×10[7] cells/ml) cell density. Three-dimensional (3D) constructs for each group were created using polymerised fibrin and cultured for 7, 14 and 21 days in vitro using chondrocyte growth medium. OAC constructs were analyzed with gross assessments and microscopic evaluation using standard histology, IHC and immunofluorescence staining, in addition to gene expression and biochemical analyses to evaluate tissue development.Results: Constructs with a high seeding density of 3×10[7] cells/ml were associated with better quality cartilage-like tissue than those seeded with 1×10[7] cells/ml based on overall tissue formation, cell association and extracellular matrix distribution. The chondrogenic properties of the constructs were further confirmed by the expression of genes encoding aggrecan core protein and collagen type II.Interpretation & conclusions: Our results confirmed that cell density was a significant factor affecting cell behaviour and aggregate production, and this was important for establishing good quality cartilage.
      Citation: Indian Journal of Medical Research 2019 149(5):641-649
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_45_17
      Issue No: Vol. 149, No. 5 (2019)
       
  • Similar regeneration of articular cartilage defects with autologous &
           allogenic chondrocytes in a rabbit model

    • Authors: P R.J.V.C. Boopalan, Viju Daniel Varghese, Solomon Sathishkumar, Sabareeswaran Arumugam, Vijayaraghavan Amarnath
      Pages: 650 - 655
      Abstract: P R.J.V.C. Boopalan, Viju Daniel Varghese, Solomon Sathishkumar, Sabareeswaran Arumugam, Vijayaraghavan Amarnath
      Indian Journal of Medical Research 2019 149(5):650-655
      Background & objectives: Articular cartilage defects in the knee have a very poor capacity for repair due to avascularity. Autologous chondrocyte transplantation (ACT) is an established treatment for articular cartilage defects. Animal studies have shown promising results with allogenic chondrocyte transplantation since articular cartilage is non-immunogenic. In addition to being economical, allogenic transplantation has less morbidity compared to ACT. This study was undertaken to compare ACT with allogenic chondrocyte transplantation in the treatment of experimentally created articular cartilage defects in rabbit knee joints.Methods: Cartilage was harvested from the left knee joints of six New Zealand white rabbits (R1-R6). The harvested chondrocytes were cultured to confluence and transplanted onto a 3.5 mm chondral defect in the right knees of 12 rabbits [autologous in 6 rabbits (R1-R6) and allogenic in 6 rabbits (R7-R12)]. After 12 wk, the rabbits were euthanized and histological evaluation of the right knee joints were done with hematoxylin and eosin and safranin O staining. Quality of the repair tissue was assessed by the modified Wakitani histological grading scale. Results: Both autologous and allogenic chondrocyte transplantation resulted in the regeneration of hyaline/mixed hyaline cartilage. The total histological scores between the two groups showed no significant difference.Interpretation & conclusions: Allogenic chondrocyte transplantation seems to be as effective as ACT in cartilage regeneration, with the added advantages of increased cell availability and reduced morbidity of a single surgery.
      Citation: Indian Journal of Medical Research 2019 149(5):650-655
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_1233_17
      Issue No: Vol. 149, No. 5 (2019)
       
  • Cloning, expression & evaluation of potential immunogenic recombinant
           capsid premembrane protein of West Nile virus

    • Authors: Jyoti S Kumar, Sivakumar Rathinam, Divanyshi Karothia, Manmohan Parida
      Pages: 656 - 661
      Abstract: Jyoti S Kumar, Sivakumar Rathinam, Divanyshi Karothia, Manmohan Parida
      Indian Journal of Medical Research 2019 149(5):656-661
      Background & objectives: West Nile virus (WNV) is a neurotropic flavivirus that has emerged globally as a significant cause of viral encephalitis. The early confirmatory diagnosis of WNV infections is important for timely clinical management and in areas where multiple flaviviruses are endemic. Diagnosis of WNV infection is primarily based on serodiagnosis, followed by virus isolation and identification. The aim of this study was to develop and evaluate a highly sensitive and specific immunoglobulin M (IgM) ELISA using the recombinant CprM protein (rWNV-CprM) for rapid, early and accurate diagnosis of WNV.Methods: The gene coding for the CprM protein of WNV was cloned and expressed in pET 28a vector followed by purification. An indirect IgM microplate ELISA using purified rWNV-CprM protein was optimized having no cross-reactivity with healthy human serum and serum samples obtained from patients with dengue and Japanese encephalitis viruses infection.Results: The comparative evaluation of this rWNV-CprM protein-specific IgM ELISA with plaque reduction neutralization test using 105 blood samples collected from patients suspected to have acute WNV infection revealed 98 per cent concordance with sensitivity and specificity of 100 and 97 per cent, respectively.Interpretation & conclusions: The recombinant CprM protein-based WNV-specific ELISA reported in this study may be useful for rapid screening of large numbers of blood samples in endemic areas during outbreaks.
      Citation: Indian Journal of Medical Research 2019 149(5):656-661
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_305_17
      Issue No: Vol. 149, No. 5 (2019)
       
  • Distribution of Chlamydia trachomatis omp A genotypes in patients
           attending a sexually transmitted disease outpatient clinic in New Delhi,
           India

    • Authors: Jyoti Rawre, Benu Dhawan, Neena Khanna, Vishnubhatla Sreenivas, Shobha Broor, Rama Chaudhry
      Pages: 662 - 670
      Abstract: Jyoti Rawre, Benu Dhawan, Neena Khanna, Vishnubhatla Sreenivas, Shobha Broor, Rama Chaudhry
      Indian Journal of Medical Research 2019 149(5):662-670
      Background & objectives: Limited data are available on the typing of Chlamydia trachomatis in India. Serovars D to K of C. trachomatis are chiefly responsible for urogenital infections. Thus, this study was conducted to determine the distribution of C. trachomatis serovars in patients with urogenital infections and to characterize omp A gene of the detected C. trachomatis isolates by sequence analysis. Presence of other co-infections was also evaluated.Methods: Endocervical swabs were collected from 324 women and urethral swabs/urine were collected from 193 men attending the sexually transmitted diseases outpatient clinic. The samples were screened for C. trachomatis by cryptic plasmid PCR and omp A gene PCR. Genotyping was performed by PCR-restriction fragment length polymorphism (RFLP) and sequencing of the omp A gene. Samples were screened for genital mycoplasmas, Neisseria gonorrhoeae, Treponema pallidum and human immunodeficiency virus (HIV).Results: C. trachomatis was found in 15.0 per cent men and 10.8 per cent women. Serovar D was the most prevalent followed by serovars E, F, I and G. Twenty two C. trachomatis isolates were selected for omp A gene sequencing. No mixed infection was found. Variability in omp A sequences was seen in 31.8 per cent cases. Both PCR-RFLP and omp A gene sequencing showed concordant results. The presence of Ureaplasma spp. and Mycoplasma hominis was observed in 18.7 and 9.5 per cent patients, respectively. Co-infection of C. trachomatis was significantly associated with Ureaplasma urealyticum and HIV.Interpretation & conclusions: The high occurence of C. trachomatis infections warrants its screening in addition to other sexually transmitted infections namely U. urealyticum and HIV. Genotyping of the omp A gene may provide additional information for vaccine development.
      Citation: Indian Journal of Medical Research 2019 149(5):662-670
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_1171_17
      Issue No: Vol. 149, No. 5 (2019)
       
  • A novel ready-to-use dry-reagent polymerase chain reaction for detection
           of Escherichia coli & Shigella species

    • Authors: Mukti Nath Mishra, Raghavendra D Kulkarni, Jeevanandam Mohanraj, S Durairaju Nisshanthini, GS Ajantha, Arun Chandrasekhar, Prachee Kenge, Shama Bhat
      Pages: 671 - 676
      Abstract: Mukti Nath Mishra, Raghavendra D Kulkarni, Jeevanandam Mohanraj, S Durairaju Nisshanthini, GS Ajantha, Arun Chandrasekhar, Prachee Kenge, Shama Bhat
      Indian Journal of Medical Research 2019 149(5):671-676
      Background & objectives: Polymerase chain reaction (PCR) has wide acceptance for rapid identification of pathogens and also for diagnosis of infectious conditions. However, because of economic and expertise constraints, a majority of small or peripheral laboratories do not use PCR. The objective of the present study was to develop a dry-reagent PCR assay as an alternative to conventional PCR to assess its applicability in routine laboratory practice using malB gene for identification of Escherichia coli as a model.Methods: A total of 184 isolates were selected for the study comprising clinical isolates of E. coli and non-E. coli including Shigella sp. and a few other control strains. The DNA was isolated from all the isolates. The isolated DNA as well as the overnight grown bacterial cultures were subjected to both conventional wet PCR and dry-reagent PCR. Results: The genomic DNA isolated from E. coli showed amplification of malB gene in both conventional wet and dry-reagent PCR and the band was observed at 491 bp. In dry-reagent PCR, the overnight grown E. coli cells also showed positive result. The non-E. coli strains other than Shigella sp. showed negative in both conventional wet and dry-reagent PCR. Shigella sp. showed positive in both conventional wet and dry-reagent PCR. Interpretation & conclusions: Considering the elimination of genomic DNA isolation step, and similar results with the conventional wet PCR, dry-reagent PCR may be a good alternative for the conventional wet PCR.
      Citation: Indian Journal of Medical Research 2019 149(5):671-676
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_1394_17
      Issue No: Vol. 149, No. 5 (2019)
       
  • Absence of Nipah virus antibodies in pigs in Mizoram State, North East
           India

    • Authors: Devendra Mourya, Pragya Yadav, Manoranjan Rout, Brahmdev Pattnaik, Anita Shete, Deepak Patil
      Pages: 677 - 679
      Abstract: Devendra Mourya, Pragya Yadav, Manoranjan Rout, Brahmdev Pattnaik, Anita Shete, Deepak Patil
      Indian Journal of Medical Research 2019 149(5):677-679

      Citation: Indian Journal of Medical Research 2019 149(5):677-679
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_1086_18
      Issue No: Vol. 149, No. 5 (2019)
       
  • Multiple papillomas in oral cavity of a six year old child

    • Authors: Jayachandran Sadaksharam, Bhaumik Joshi
      Pages: 680 - 681
      Abstract: Jayachandran Sadaksharam, Bhaumik Joshi
      Indian Journal of Medical Research 2019 149(5):680-681

      Citation: Indian Journal of Medical Research 2019 149(5):680-681
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_528_18
      Issue No: Vol. 149, No. 5 (2019)
       
  • Multiple periarticular nodules diagnosed as gout on fine-needle aspiration
           cytology

    • Authors: Anjali Goyal, Vani Patel
      Pages: 682 - 683
      Abstract: Anjali Goyal, Vani Patel
      Indian Journal of Medical Research 2019 149(5):682-683

      Citation: Indian Journal of Medical Research 2019 149(5):682-683
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_1505_17
      Issue No: Vol. 149, No. 5 (2019)
       
  • Lower urinary tract symptoms and benign prostatic hyperplasia: From
           research to bedside

    • Authors: Apul Goel
      Pages: 684 - 685
      Abstract: Apul Goel
      Indian Journal of Medical Research 2019 149(5):684-685

      Citation: Indian Journal of Medical Research 2019 149(5):684-685
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_323_19
      Issue No: Vol. 149, No. 5 (2019)
       
  • Hemophilia and von Willebrand disease: Factor VIII and von Willebrand
           factor

    • Authors: Prashant Sharma
      Pages: 685 - 686
      Abstract: Prashant Sharma
      Indian Journal of Medical Research 2019 149(5):685-686

      Citation: Indian Journal of Medical Research 2019 149(5):685-686
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/ijmr.IJMR_502_19
      Issue No: Vol. 149, No. 5 (2019)
       
  • Retraction: Evaluation of various culture techniques for identification of
           hookworm species from stool samples of children

    • Pages: 687 - 687
      Abstract:
      Indian Journal of Medical Research 2019 149(5):687-687

      Citation: Indian Journal of Medical Research 2019 149(5):687-687
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/0971-5916.264275
      Issue No: Vol. 149, No. 5 (2019)
       
  • Erratum: Emerging/re-emerging viral diseases & new viruses on
           the Indian horizon

    • Pages: 688 - 688
      Abstract:
      Indian Journal of Medical Research 2019 149(5):688-688

      Citation: Indian Journal of Medical Research 2019 149(5):688-688
      PubDate: Mon,12 Aug 2019
      DOI: 10.4103/0971-5916.264276
      Issue No: Vol. 149, No. 5 (2019)
       
 
 
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