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Publisher: Medknow Publishers   (Total: 356 journals)

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Showing 1 - 200 of 356 Journals sorted alphabetically
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advances in Human Biology     Open Access  
African J. for Infertility and Assisted Conception     Open Access  
African J. of Business Ethics     Open Access   (Followers: 7)
African J. of Medical and Health Sciences     Open Access  
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.269, h-index: 10)
African J. of Trauma     Open Access  
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access  
Ancient Science of Life     Open Access   (Followers: 6)
Anesthesia : Essays and Researches     Open Access   (Followers: 7)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.331, h-index: 15)
Annals of Bioanthropology     Open Access   (Followers: 2)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 12, SJR: 0.408, h-index: 15)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.308, h-index: 14)
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 5, SJR: 0.441, h-index: 10)
Annals of Saudi Medicine     Open Access   (SJR: 0.24, h-index: 29)
Annals of Thoracic Medicine     Open Access   (Followers: 4, SJR: 0.388, h-index: 19)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 15, SJR: 0.148, h-index: 5)
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Intl. Surgery     Open Access   (Followers: 9)
Archives of Medicine and Health Sciences     Open Access   (Followers: 2)
Archives of Pharmacy Practice     Open Access   (Followers: 4)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 3)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.879, h-index: 49)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.362, h-index: 10)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access   (Followers: 1)
Bulletin of Faculty of Physical Therapy     Open Access  
Cancer Translational Medicine     Open Access   (Followers: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Dermatology Review     Open Access  
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 10, SJR: 0.82, h-index: 12)
Contemporary Clinical Dentistry     Open Access   (Followers: 4)
Current Medical Issues     Open Access  
CytoJ.     Open Access   (Followers: 2, SJR: 0.339, h-index: 19)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.131, h-index: 4)
Dental Research J.     Open Access   (Followers: 9)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 4, SJR: 0.205, h-index: 22)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1)
Egyptian J. of Dermatology and Venerology     Open Access  
Egyptian J. of Haematology     Open Access  
Egyptian J. of Internal Medicine     Open Access  
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.121, h-index: 3)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access  
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Orthopaedic J.     Open Access  
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.473, h-index: 8)
Environmental Disease     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.496, h-index: 11)
European J. of General Dentistry     Open Access   (Followers: 1)
European J. of Prosthodontics     Open Access   (Followers: 2)
European J. of Psychology and Educational Studies     Open Access   (Followers: 6)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.107, h-index: 5)
Genome Integrity     Open Access   (Followers: 4, SJR: 1.227, h-index: 12)
Global J. of Transfusion Medicine     Open Access  
Heart India     Open Access  
Heart Views     Open Access  
Hepatitis B Annual     Open Access   (Followers: 3)
IJS Short Reports     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 2)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.302, h-index: 13)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (SJR: 0.318, h-index: 26)
Indian J. of Cerebral Palsy     Open Access  
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.618, h-index: 16)
Indian J. of Critical Care Medicine     Open Access   (Followers: 1, SJR: 0.307, h-index: 16)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.243, h-index: 24)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.448, h-index: 16)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 2, SJR: 0.563, h-index: 29)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access  
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4)
Indian J. of Health Sciences     Open Access   (Followers: 1)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.292, h-index: 9)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.53, h-index: 34)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.716, h-index: 60)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.207, h-index: 31)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 1, SJR: 0.233, h-index: 12)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.213, h-index: 5)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 4, SJR: 0.203, h-index: 13)
Indian J. of Ophthalmology     Open Access   (Followers: 4, SJR: 0.536, h-index: 34)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 9, SJR: 0.393, h-index: 15)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.218, h-index: 5)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 1)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.35, h-index: 12)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 1, SJR: 0.285, h-index: 22)
Indian J. of Pharmacology     Open Access   (SJR: 0.347, h-index: 44)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.303, h-index: 13)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.496, h-index: 15)
Indian J. of Psychological Medicine     Open Access   (Followers: 1, SJR: 0.344, h-index: 9)
Indian J. of Public Health     Open Access   (Followers: 1, SJR: 0.444, h-index: 17)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4, SJR: 0.253, h-index: 14)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.169, h-index: 7)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.313, h-index: 9)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.366, h-index: 16)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Critical Illness and Injury Science     Open Access  
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 2)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 4, SJR: 0.229, h-index: 13)
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 1)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 2)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 7)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.239, h-index: 4)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.523, h-index: 15)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 6, SJR: 0.611, h-index: 9)
Intl. J. of Trichology     Open Access   (SJR: 0.37, h-index: 10)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 2)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 4, SJR: 0.427, h-index: 15)
J. of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 8, SJR: 0.416, h-index: 14)
J. of Applied Hematology     Open Access  
J. of Association of Chest Physicians     Open Access   (Followers: 2)
J. of Basic and Clinical Reproductive Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Therapeutics     Open Access   (Followers: 4, SJR: 0.359, h-index: 21)
J. of Carcinogenesis     Open Access   (Followers: 1, SJR: 1.152, h-index: 26)
J. of Cardiothoracic Trauma     Open Access  
J. of Cardiovascular Disease Research     Open Access   (Followers: 3, SJR: 0.351, h-index: 13)
J. of Cardiovascular Echography     Open Access   (SJR: 0.134, h-index: 2)
J. of Cleft Lip Palate and Craniofacial Anomalies     Open Access   (Followers: 2)
J. of Clinical and Preventive Cardiology     Open Access  
J. of Clinical Imaging Science     Open Access   (Followers: 1, SJR: 0.277, h-index: 8)
J. of Clinical Neonatology     Open Access   (Followers: 1)
J. of Clinical Ophthalmology and Research     Open Access   (Followers: 1)
J. of Clinical Sciences     Open Access  
J. of Conservative Dentistry     Open Access   (Followers: 4, SJR: 0.532, h-index: 10)
J. of Craniovertebral Junction and Spine     Open Access   (Followers: 4, SJR: 0.199, h-index: 9)
J. of Current Medical Research and Practice     Open Access  
J. of Current Research in Scientific Medicine     Open Access  
J. of Cutaneous and Aesthetic Surgery     Open Access   (Followers: 1)
J. of Cytology     Open Access   (Followers: 1, SJR: 0.274, h-index: 9)
J. of Dental and Allied Sciences     Open Access   (Followers: 1)
J. of Dental Implants     Open Access   (Followers: 7)
J. of Dental Lasers     Open Access   (Followers: 2)
J. of Dental Research and Review     Open Access   (Followers: 1)
J. of Digestive Endoscopy     Open Access   (Followers: 3)
J. of Dr. NTR University of Health Sciences     Open Access  
J. of Earth, Environment and Health Sciences     Open Access   (Followers: 1)
J. of Education and Ethics in Dentistry     Open Access   (Followers: 5)
J. of Education and Health Promotion     Open Access   (Followers: 5)
J. of Emergencies, Trauma and Shock     Open Access   (Followers: 8, SJR: 0.353, h-index: 14)
J. of Engineering and Technology     Open Access   (Followers: 6)
J. of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
J. of Family and Community Medicine     Open Access  
J. of Family Medicine and Primary Care     Open Access   (Followers: 8)

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Journal Cover Indian Journal of Medical Sciences
  [SJR: 0.207]   [H-I: 31]   [2 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 0019-5359 - ISSN (Online) 0019-5359
   Published by Medknow Publishers Homepage  [356 journals]
  • Eliminating HIV & AIDS in India: A roadmap to zero new HIV infections,
           zero discrimination & zero AIDS-related deaths

    • Authors: Riya Palchaudhuri, Max Niggl, Clovis Steve Palmer
      Pages: 789 - 792
      Abstract: Riya Palchaudhuri, Max Niggl, Clovis Steve Palmer
      Indian Journal of Medical Research 2016 144(6):789-792

      Citation: Indian Journal of Medical Research 2016 144(6):789-792
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_1902_16
      Issue No: Vol. 144, No. 6 (2017)
       
  • Role of decidual natural killer cells & macrophages in pre-eclampsia

    • Authors: Pranab Dey
      Pages: 793 - 795
      Abstract: Pranab Dey
      Indian Journal of Medical Research 2016 144(6):793-795

      Citation: Indian Journal of Medical Research 2016 144(6):793-795
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_863_16
      Issue No: Vol. 144, No. 6 (2017)
       
  • Insights into in vitro environments for human cartilage tissue engineering

    • Authors: Samuel J. K. Abraham, Hiroshi Yoshioka
      Pages: 796 - 798
      Abstract: Samuel J. K. Abraham, Hiroshi Yoshioka
      Indian Journal of Medical Research 2016 144(6):796-798

      Citation: Indian Journal of Medical Research 2016 144(6):796-798
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_1237_16
      Issue No: Vol. 144, No. 6 (2017)
       
  • Is elimination of kala-azar feasible by 2017?

    • Authors: CP Thakur
      Pages: 799 - 802
      Abstract: CP Thakur
      Indian Journal of Medical Research 2016 144(6):799-802

      Citation: Indian Journal of Medical Research 2016 144(6):799-802
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_335_16
      Issue No: Vol. 144, No. 6 (2017)
       
  • Ketoprofen-induced photoallergic dermatitis

    • Authors: Tiffany Yvonne Loh, Philip R Cohen
      Pages: 803 - 806
      Abstract: Tiffany Yvonne Loh, Philip R Cohen
      Indian Journal of Medical Research 2016 144(6):803-806
      Drug-induced photosensitivity reactions are significant adverse effects. Ketoprofen is one of the most common drugs that can cause skin rash in sun-exposed areas. Non-steroidal anti-inflammatory drugs (NSAIDs), such as ketoprofen, are often used for a variety of symptoms, including pain and fever. An understanding of the presentation and clinical course of ketoprofen-induced photosensitivity is necessary to correctly diagnose and manage this condition. Ketoprofen-induced photosensitivity reactions usually present as photoallergic dermatitis, which is a cell-mediated immune process. The benzophenone moiety in ketoprofen plays a major role in ketoprofen's ability to act as a photosensitizer. Several agents, such as fenofibrate and octocrylene have been found to be associated with aggravation of ketoprofen-induced photoallergic dermatitis or cross-photosensitization, and these reactions result from structural similarities with ketoprofen. Treatment of ketoprofen-induced photoallergic dermatitis includes discontinuation of ketoprofen, topical or systemic corticosteroids and avoidance of sun exposure and agents known to exacerbate dermatitis. In conclusion, photoallergic dermatitis is a significant adverse effect of ketoprofen. Some agents known to worsen dermatitis may be found in sun protection products (notably, octocrylene in sunscreen). Educating the patient to avoid these products is critical to treatment. Since NSAIDs, such as ketoprofen, are used commonly for a variety of illnesses, drug-induced photoallergic dermatitis should be high on the differential in individuals using these medications who present with acute onset of a rash in sun-exposed areas.
      Citation: Indian Journal of Medical Research 2016 144(6):803-806
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_626_16
      Issue No: Vol. 144, No. 6 (2017)
       
  • Diagnostic & prognostic role of microRNAs in paediatric acute myeloid
           leukaemia

    • Authors: Sachin Kumar, Sameer Bakhshi
      Pages: 807 - 814
      Abstract: Sachin Kumar, Sameer Bakhshi
      Indian Journal of Medical Research 2016 144(6):807-814
      Dysregulation in microRNAs (miRNAs) expression has been observed in distinct acute myeloid leukaemia (AML) subtypes, and their potential as an effective diagnostic and prognostic biomarker is slowly being realized. Certain miRNAs have been found to be associated with various cytogenetic and molecular abnormalities of prognostic significance in AML. Experimental evidences have indicated the potential of modulating miRNA expression as an effective antileukaemic strategy. This has opened a new window for miRNAs-based targeted therapies. In this review, we present results of some studies analyzing the dysregulation in miRNAs expression pattern in paediatric AML and also discuss their use as diagnostic and prognostic markers.
      Citation: Indian Journal of Medical Research 2016 144(6):807-814
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_220_15
      Issue No: Vol. 144, No. 6 (2017)
       
  • Respiratory sinus arrhythmia as a non-invasive index of
           'brain-heart' interaction in stress

    • Authors: Ingrid Tonhajzerova, Michal Mestanik, Andrea Mestanikova, Alexander Jurko
      Pages: 815 - 822
      Abstract: Ingrid Tonhajzerova, Michal Mestanik, Andrea Mestanikova, Alexander Jurko
      Indian Journal of Medical Research 2016 144(6):815-822
      Respiratory sinus arrhythmia (RSA) is accepted as a peripheral marker of cardiac-linked parasympathetic regulation. According to polyvagal theory, the RSA is also considered as the index of emotion regulation. The neurovisceral integration model posits that parasympathetic modulation of the heart marked by RSA is related to complex nervous regulation associated with emotional and cognitive processing. From this perspective, high resting RSA amplitude associated with a greater withdrawal during stressors and subsequent recovery could represent a flexible and adaptive physiological response system to a challenge. Conversely, low resting RSA accompanied by an inadequate reactivity to stress might reflect maladaptive regulatory mechanisms. The RSA reactivity is different with various types of stressors: while the RSA decreases to cognitive tasks indicating a vagal withdrawal, the RSA magnitude increases to emotional challenge indicating an effective cognitive processing of emotional stimuli. The RSA reactivity to stress could have important implications for several mental disorders, e.g. depressive or anxiety disorder. It seems that the study of the RSA, as a non-invasive index of 'brain-heart' communication, could provide important information on the pathway linked to mental and physical health.
      Citation: Indian Journal of Medical Research 2016 144(6):815-822
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_1447_14
      Issue No: Vol. 144, No. 6 (2017)
       
  • Number of decidual natural killer cells & macrophages in pre-eclampsia

    • Authors: Jelena Milosevic-Stevanovic, Miljan Krstic, Dragana Radovic-Janosevic, Jasmina Popovic, Marija Tasic, Slavica Stojnev
      Pages: 823 - 830
      Abstract: Jelena Milosevic-Stevanovic, Miljan Krstic, Dragana Radovic-Janosevic, Jasmina Popovic, Marija Tasic, Slavica Stojnev
      Indian Journal of Medical Research 2016 144(6):823-830
      Background & objectives: The process of human placentation is complex and still not well understood. This study was aimed to examine the relationship between clinical features of pre-eclampsia and degree of trophoblastic invasion after its immunohistochemical visualization in the context of possible alterations in the number of natural killer (NK) cells and macrophages in the decidua. Methods: This prospective study included a study group comprising 30 pregnant women with pre-eclampsia delivered by caesarean section and a control group comprising 20 healthy pregnant women also delivered by caesarean section. Samples of placental bed obtained during caesarean section were analyzed after immunohistochemical labelling CD56 + NK cells, CD68 + macrophages and cytokeratin 7 trophoblastic cells. Results: In pre-eclampsia, there was a significantly lower number of CD56 + NK cells in the decidua (P
      Citation: Indian Journal of Medical Research 2016 144(6):823-830
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_776_15
      Issue No: Vol. 144, No. 6 (2017)
       
  • Bone marrow extract as a growth supplement for human iliac apophyseal
           chondrocyte culture

    • Authors: Balasubramanian Balakumar, Karthikeyan Rajagopal, Vrisha Madhuri
      Pages: 831 - 837
      Abstract: Balasubramanian Balakumar, Karthikeyan Rajagopal, Vrisha Madhuri
      Indian Journal of Medical Research 2016 144(6):831-837
      Background & objectives: Human bone marrow is rich in various growth factors which may support the chondrocyte growth. This study was conducted to compare the culture characteristics of human growth plate chondrocyte in foetal bovine serum (FBS) and human autologous bone marrow extract (BME) in monolayer culture. Methods: Iliac crest apophyseal cartilage was harvested from four donors, aged between two and nine years, undergoing hip surgery. Chondrocytes were propagated under two culture conditions, with 10 per cent FBS and 10 per cent autologous BME harvested from the same donors. Cells were harvested at 7, 14 and 21 days to assess viability, morphology, cell count and immunocytochemistry. Results: With an initial seeding density of 2500 cells/cm 2 , the average yield in monolayer cultured with FBS was 3.35 × 10 5 , 5.9 × 10 5 , 14.1 × 10 5 and BME was 0.66 × 10 5 , 1.57 × 10 5 and 3.48 × 10 5 at 7, 14 and 21 days, respectively. Viability was 98.21 per cent with FBS and 97.45 per cent with BME at 21 days. In BME supplemented cultures, hyaline phenotype was maintained up to 21 days. The yield was higher in the FBS supplemented group; however, the phenotype could not be maintained by the FBS group as long as BME group. Interpretation & conclusions: Autologous BME was found to be a safer alternative to FBS for human studies. BME could maintain the hyaline phenotype for a longer time. Ways to enhance the cell yield needs to be explored in future studies.
      Citation: Indian Journal of Medical Research 2016 144(6):831-837
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_8_15
      Issue No: Vol. 144, No. 6 (2017)
       
  • Feeder & basic fibroblast growth factor-free culture of human embryonic
           stem cells: Role of conditioned medium from immortalized human feeders

    • Authors: Pooja Teotia, Shilpa Sharma, Balram Airan, Sujata Mohanty
      Pages: 838 - 851
      Abstract: Pooja Teotia, Shilpa Sharma, Balram Airan, Sujata Mohanty
      Indian Journal of Medical Research 2016 144(6):838-851
      Background & objectives: Human embryonic stem cell (hESC) lines are commonly maintained on inactivated feeder cells, in the medium supplemented with basic fibroblast growth factor (bFGF). However, limited availability of feeder cells in culture, and the high cost of growth factors limit their use in scalable expansion of hESC cultures for clinical application. Here, we describe an efficient and cost-effective feeder and bFGF-free culture of hESCs using conditioned medium (CM) from immortalized feeder cells. Methods: KIND-1 hESC cell line was cultured in CM, collected from primary mouse embryonic fibroblast, human foreskin fibroblast (HFF) and immortalized HFF (I-HFF). Pluripotency of KIND-1 hESC cell line was confirmed by expression of genes, proteins and cell surface markers. Results: In culture, these cells retained normal morphology, expressed all cell surface markers, could differentiate to embryoid bodies upon culture in vitro. Furthermore, I-HFF feeder cells without supplementation of bFGF released ample amount of endogenous bFGF to maintain stemness of hESC cells. Interpretation & conclusions: The study results described the use of CM from immortalized feeder cells as a consistent source and an efficient, inexpensive feeder-free culture system for the maintenance of hESCs. Moreover, it was possible to maintain hESCs without exogenous supplementation of bFGF. Thus, the study could be extended to scalable expansion of hESC cultures for therapeutic purposes.
      Citation: Indian Journal of Medical Research 2016 144(6):838-851
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_424_15
      Issue No: Vol. 144, No. 6 (2017)
       
  • Preclinical safety & toxicity evaluation of pooled, allogeneic human bone
           marrow-derived mesenchymal stromal cells

    • Authors: Mathiyazhagan Rengasamy, Pawan Kumar Gupta, Udaykumar Kolkundkar, Gurbind Singh, Sudha Balasubramanian, Swathi SundarRaj, Anoop Chullikana, Anish Sen Majumdar
      Pages: 852 - 864
      Abstract: Mathiyazhagan Rengasamy, Pawan Kumar Gupta, Udaykumar Kolkundkar, Gurbind Singh, Sudha Balasubramanian, Swathi SundarRaj, Anoop Chullikana, Anish Sen Majumdar
      Indian Journal of Medical Research 2016 144(6):852-864
      Background & objectives: Administration of ex vivo-expanded human bone marrow-derived mesenchymal stromal cells (hBMMSC) obtained from single donors has shown therapeutic benefits in both preclinical and clinical studies. In this study, the safety, toxicity and biodistribution profiles of a pooled hBMMSC population, produced from three healthy donors were assessed in rodent and non-rodents. Methods: The pooled hBMMSC population was characterized by their expression of various cell surface markers, differentiation potential and immunomodulatory activity. To establish in vivo safety of the pooled cells, these were administered by various injection routes into rodents and non-rodents to determine overall toxicity, biodistribution and tumorigenic potential in a series of preclinical studies. Results: Single injections of hBMMSC at various doses through intravenous or intramuscular routes did not cause toxicity in rats and rabbits. In addition, repeat administration of hBMMSC was also well tolerated by rats, and no prenatal toxicity was observed by multiple administration in the same animal species. Ex vivo-expanded and cryopreserved hBMMSCs did not induce tumour formation in severe combined immunodeficient (SCID) mice. Interpretation & conclusions: Our results showed that the pooled hBMMSC population was non-toxic, non-teratogenic and non-tumorigenic in animals. Further studies need to be done to find out if it can be safely administered in human patients.
      Citation: Indian Journal of Medical Research 2016 144(6):852-864
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_1842_15
      Issue No: Vol. 144, No. 6 (2017)
       
  • IREB2, CHRNA5, CHRNA3, FAM13A & hedgehog interacting protein genes
           polymorphisms & risk of chronic obstructive pulmonary disease in Tatar
           population from Russia

    • Authors: Gulnaz Faritovna Korytina, Leysan Zinurovna Akhmadishina, Elena Vitalievna Viktorova, Olga Vladimirovna Kochetova, Tatyana Victorovna Viktorova
      Pages: 865 - 876
      Abstract: Gulnaz Faritovna Korytina, Leysan Zinurovna Akhmadishina, Elena Vitalievna Viktorova, Olga Vladimirovna Kochetova, Tatyana Victorovna Viktorova
      Indian Journal of Medical Research 2016 144(6):865-876
      Background & objectives: Chronic obstructive pulmonary disease (COPD) is a complex chronic inflammatory disease of the respiratory system affecting primarily distal respiratory pathways and lung parenchyma. This study was aimed at investigating the association of COPD with IREB2, CHRNA5, CHRNA3, FAM13A and hedgehog interacting protein (HHIP) genes in a Tatar population from Russia. Methods: Six single nucleotide polymorphisms (SNPs) (rs13180, rs16969968, rs1051730, rs6495309, rs7671167, rs13118928) were genotyped by the real-time polymerase chain reaction in this study (511 COPD patients and 508 controls). Logistic regression was used to detect the association of SNPs and haplotypes of linked loci in different models. Linear regression analyses were performed to estimate the relationship between SNPs and lung function parameters and pack-years. Results: The rs13180 (IREB2), rs16969968 (CHRNA5) and rs1051730 (CHRNA3) were significantly associated with COPD in additive model [Padj =0.00001, odds ratio (OR)=0.64; Padj =0.0001, OR=1.41 and Padj =0.0001, OR=1.47]. The C-G haplotype by rs13180 and rs1051730 was a protective factor for COPD in our population (Padj =0.0005, OR=0.61). These results were confirmed only in smokers. The rs16969968 and rs1051730 were associated with decrease of forced expiratory volume in 1 sec % predicted (Padj =0.005 and Padj =0.0019). Interpretation & conclusions: Our study showed the association of rs13180, rs16969968 and rs1051730 with COPD and lung function in Tatar population from Russia. Further studies need to be done in other ethnic populations.
      Citation: Indian Journal of Medical Research 2016 144(6):865-876
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_1233_14
      Issue No: Vol. 144, No. 6 (2017)
       
  • Viruses causing severe acute respiratory infections (SARI) in children
           ≤5 years of age at a tertiary care hospital in Rajasthan, India

    • Authors: Bharti Malhotra, M Anjaneya Swamy, PV Janardhan Reddy, ML Gupta
      Pages: 877 - 885
      Abstract: Bharti Malhotra, M Anjaneya Swamy, PV Janardhan Reddy, ML Gupta
      Indian Journal of Medical Research 2016 144(6):877-885
      Background & objectives: Severe acute respiratory infection (SARI) is one of the leading causes of death among children worldwide. As different respiratory viruses exhibit similar symptoms, simultaneous detection of these viruses in a single reaction mixture can save time and cost. The present study was done in a tertiary care children's hospital for rapid identification of viruses causing SARI among children less than or equal to five years of age using multiplex real-time reverse transcription polymerase chain reaction (RT-PCR) kit. Methods: A total of 155 throat swabs were collected from equal number of children suspected to have SARI and processed for extraction of nucleic acids using automated extraction system. Multiplex real-time RT-PCR was done to identify the viruses in the samples. Results: The overall positivity for viruses in the study was found to be 72.9 per cent with a co-infection rate of 19.5 per cent. Human metapneumovirus (HMPV) was the predominant virus detected in 25.7 per cent children followed by influenza A (H1N1)pdm09, human rhinovirus (HRV) and human adenovirus (HAdV) in 19.9, 11.0 and 8.8 per cent children, respectively. The HMPV was at its peak in February 2013, HAdV showed two peaks in March-April, 2012 and November 2012-March 2013 while HRV was detected throughout the year. Interpretation & conclusions: Multiplex real-time PCR helped in rapid identification of viruses. Seventeen viruses were detected in SARI cases with overall positivity of 72.9 per cent. HMPV was the most predominant virus. However, for better clinico-virological correlation, studies are required with complete work up of all the aetiological agents, clinical profile of patients and treatment outcome.
      Citation: Indian Journal of Medical Research 2016 144(6):877-885
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_22_15
      Issue No: Vol. 144, No. 6 (2017)
       
  • Immunogenicity & safety of a single dose of live-attenuated Japanese
           encephalitis vaccine SA 14-14-2 in adults

    • Authors: Siraj Ahmed Khan, Sanjeeb Kakati, Prafulla Dutta, Purvita Chowdhury, Jani Borah, Rashmee Topno, Santoshkumar M Jadhav, Pradyumna K Mohapatra, Jagadish Mahanta, Mohan D Gupte
      Pages: 886 - 892
      Abstract: Siraj Ahmed Khan, Sanjeeb Kakati, Prafulla Dutta, Purvita Chowdhury, Jani Borah, Rashmee Topno, Santoshkumar M Jadhav, Pradyumna K Mohapatra, Jagadish Mahanta, Mohan D Gupte
      Indian Journal of Medical Research 2016 144(6):886-892
      Background & objectives: Japanese encephalitis (JE) caused by mosquito-borne Flavivirus is one of the leading causes of viral encephalitis in Asia. Control strategies include vector control and human vaccination. Due to lack of immunization programmes in endemic regions, there are still high mortality and morbidity. A live-attenuated SA 14-14-2 JE vaccine (LAJEV) has been licensed and used in Asian countries, including India. We report the assessment of immunogenicity and safety of the vaccine in adults during the first mass adult vaccination campaign carried out in Assam, India. Methods: One thousand and seventy five adults (aged ≥15 yr) who received LAJEV were monitored for adverse events following immunization for one year. The safety assessment of vaccinated population was evaluated till 28 days and at 6 and 12 months. Blood samples collected from the enrolled participants were tested by plaque reduction neutralization test (PRNT 50 ) to assess the neutralizing antibody titres (NATs) before vaccination and 28 days, six and 12 months post-vaccination (PV). Results: Among the 1075 vaccinated individuals, four reported minor adverse effects from 30 min to 28 days PV. Based on the pre-vaccination NAT, the study participants were categorized as seronegative, moderately seropositive and strongly seropositive. Nearly 85.5 per cent of JE seronegative participants seroconverted by 28 days PV. The geometric mean titre (GMT) in all the three groups increased by 28 days and decreased by six and 12 months PV. Nearly 60 per cent of the moderately positive individuals exhibited four-fold rise in GMT, 28 days PV. Almost 95.5 per cent of the participants in the study population remained seroprotected at the end of 12 months PV. Interpretation & conclusions: This study on immunogenicity and safety of LAJEV in adults showed that a single dose of the live-attenuated vaccine was safe and induced protective immunity to both JE seronegative and naturally seropositive adults. Further study is required to find out long term protective efficacy of this vaccine.
      Citation: Indian Journal of Medical Research 2016 144(6):886-892
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_712_15
      Issue No: Vol. 144, No. 6 (2017)
       
  • Abundance & distribution of trombiculid mites & Orientia tsutsugamushi,
           the vectors & pathogen of scrub typhus in rodents & shrews collected from
           Puducherry & Tamil Nadu, India

    • Authors: Sadanandane Candasamy, Elango Ayyanar, Kummankottil Paily, Patricia Anitha Karthikeyan, Agatheswaran Sundararajan, Jambulingam Purushothaman
      Pages: 893 - 900
      Abstract: Sadanandane Candasamy, Elango Ayyanar, Kummankottil Paily, Patricia Anitha Karthikeyan, Agatheswaran Sundararajan, Jambulingam Purushothaman
      Indian Journal of Medical Research 2016 144(6):893-900
      Background & objectives: Human cases of scrub typhus are reported every year from Puducherry and adjoining areas in southern India. However, information on the presence of causative agent, Orientia tsutsugamushi, and its vectors is lacking. Hence, the objective of the study was to find out the vector as well as pathogen distribution in rodents and shrews present in the scrub typhus-reported areas in southern India. Methods: Trombiculid mites were collected by combing rats and shrews collected using Sherman traps and identified to species level following standard taxonomical keys. The serum samples of the animals were used for Weil-Felix test and the clots containing blood cells were used for DNA extraction and polymerase chain reaction (PCR). Results: A total of 181 animals comprising four rodent species and one shrew species were collected from 12 villages. High proportion of chiggers was collected from the shrew, Suncus murinus (79.1%) and Rattus rattus (47.6%). A total of 10,491 trombiculid mites belonging to nine species were collected. Leptotrombidium deliense, the known vector of scrub typhus pathogen, was the predominant species (71.0%) and the chigger (L. deliense) index was 41.1 per animal. Of the 50 animals screened for the pathogen, 28 showed agglutination against OX-K in Weil-Felix test indicating the presence of antibodies against O. tsutsugamushi, the causative agent of scrub typhus. PCR carried out with the DNA extracted from blood samples of two of the animals were positive for GroEl gene of O. tsutsugamushi. Interpretation & conclusions: L. deliense index was well above the critical limit of chigger load, indicating that all the villages were receptive for high risk of transmission of scrub typhus to human. Pathogen positivity was higher among animals collected from villages recorded for higher chigger indices due to active transmission between the chigger mites and reservoir host animals. The results are suggestive of routine vector/pathogen surveillance at hot spots to initiate timely preventive measures.
      Citation: Indian Journal of Medical Research 2016 144(6):893-900
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_1390_15
      Issue No: Vol. 144, No. 6 (2017)
       
  • Scrub typhus in Uttarakhand & adjoining Uttar Pradesh: Seasonality,
           clinical presentations & predictors of mortality

    • Authors: Anurag Bhargava, Reshma Kaushik, Rajeev Mohan Kaushik, Anita Sharma, Sohaib Ahmad, Minakshi Dhar, Garima Mittal, Sushant Khanduri, Priyannk Pant, Rajesh Kakkar
      Pages: 901 - 909
      Abstract: Anurag Bhargava, Reshma Kaushik, Rajeev Mohan Kaushik, Anita Sharma, Sohaib Ahmad, Minakshi Dhar, Garima Mittal, Sushant Khanduri, Priyannk Pant, Rajesh Kakkar
      Indian Journal of Medical Research 2016 144(6):901-909
      Background & objectives: Scrub typhus is a re-emerging mite-borne rickettsiosis, which continues to be underdiagnosed, with lethal consequences. The present study was conducted to determine the seasonality, clinical presentation and predictors of mortality in patients with scrub typhus at a tertiary care teaching hospital in northern India. Methods: Scrub typhus was suspected in patients attending the hospital as per the standard case definition and serological evidence was obtained by performing an IgM ELISA. Results: A total of 284 patients with scrub typhus from urban and rural areas were seen, predominantly from July to November. The most common clinical presentation was a bilateral community-acquired pneumonia (CAP), which resembled pneumonia due to atypical pathogens and often progressed to acute respiratory distress syndrome (ARDS). An acute undifferentiated febrile illness (AUFI) or a febrile illness associated with altered sensorium, aseptic meningitis, shock, abdominal pain, gastrointestinal bleeding or jaundice was also seen. Eschars were seen in 17 per cent of patients, and thrombocytopenia, transaminitis and azotaemia were frequent. There were 24 deaths (8.5%) caused predominantly by ARDS and multi-organ dysfunction. The mortality in patients with ARDS was high (37%). ARDS [odds ratio (OR)=38.29, 95% confidence interval (CI): 9.93, 147.71] and acute kidney injury (OR=8.30, 95% CI: 2.21, 31.21) were the major predictors of death. Interpretation & conclusions: The present findings indicate that scrub typhus may be considered a cause of CAP, ARDS, AUFI or a febrile illness with multisystem involvement, in Uttarakhand and Uttar Pradesh, especially from July to November. Empiric therapy of CAP may include doxycycline or azithromycin to ensure coverage of underlying unsuspected scrub typhus.
      Citation: Indian Journal of Medical Research 2016 144(6):901-909
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_1764_15
      Issue No: Vol. 144, No. 6 (2017)
       
  • Protection against osteoarthritis in experimental animals by nanogold
           conjugated snake venom protein toxin gold nanoparticle-Naja kaouthia
           cytotoxin 1

    • Authors: Antony Gomes, Partha Pratim Saha, Tanmoy Bhowmik, Anjan Kumar Dasgupta, Subir Chandra Dasgupta
      Pages: 910 - 917
      Abstract: Antony Gomes, Partha Pratim Saha, Tanmoy Bhowmik, Anjan Kumar Dasgupta, Subir Chandra Dasgupta
      Indian Journal of Medical Research 2016 144(6):910-917
      Background & objectives: Increased severity of osteoarthritis (OA) and adverse side effects of its treatment led to the search for alternative therapies. It was previously reported that snake venom protein toxin Naja kaouthia cytotoxin 1 (NKCT1) and gold nanoparticle (GNP) individually have potential against excremental arthritis. In this study, we analyzed the protective activity of GNP conjugated protein toxin NKCT1 (GNP-NKCT1) against experimental OA. Methods: Gold nanoparticle conjugation with NKCT1 (GNP-NKCT1) was done and its physiochemical properties were studied. OA was induced in male albino rats by intra-articular injection of bacterial collagenase and treatment was done with NKCT1/GNP-NKCT1/standard drug (indomethacin). Physical parameter (ankle diameter), urinary markers (hydroxyproline, glucosamine, pyridinoline, deoxypyridinoline), serum and synovial membrane pro-inflammatory markers [tumour necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), IL-17, vascular endothelial growth factor (VEGF)] and matrix metalloproteinase 1 (MMP1) were measured. Joint histopathology and scanning electron microscopy imaging of articular cartilage surface were also done. Results: Physical parameters, urinary markers, serum and synovial membrane pro-inflammatory makers and MMP1 were increased in arthritic rats and significantly restored after GNP-NKCT1/NKCT1 treatment. Joint histopathology and scanning electron microscopy imaging of articular cartilage surface also indicated the protective effect of GNP-NKCT1 against inflammatory response and cartilage degradation in osteoarthritic rats. Interpretation & conclusions: In this study restoration of the arthritic markers and bone degradation by GNP-NKCT1 treatment indicated the anti-osteoarthritic property of GNP-NKCT1. Further studies need to be done to confirm these findings.
      Citation: Indian Journal of Medical Research 2016 144(6):910-917
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_1078_14
      Issue No: Vol. 144, No. 6 (2017)
       
  • Epidemiological & clinical profile of influenza A (H1N1) 2009 virus
           infections during 2015 epidemic in Rajasthan

    • Authors: Bharti Malhotra, Ruchi Singh, Pratibha Sharma, Deepa Meena, Jyoti Gupta, Aditya Atreya, BR Meena
      Pages: 918 - 923
      Abstract: Bharti Malhotra, Ruchi Singh, Pratibha Sharma, Deepa Meena, Jyoti Gupta, Aditya Atreya, BR Meena
      Indian Journal of Medical Research 2016 144(6):918-923
      Background & objectives: Pandemic influenza A (H1N1) 2009 virus emerged in 2009 and caused pandemic with high morbidity and mortality in India and worldwide. The number of H1N1-positive cases varied in different years in Rajasthan. The objective of the study was to present the epidemiological profile of pandemic influenza A (H1N1) 2009 virus cases in Rajasthan from January to March 2015. Methods: A retrospective descriptive, record-based analysis of suspected and confirmed cases of pandemic influenza A (H1N1) 2009 virus infection in Rajasthan, India, from January to March 2015 was performed. Testing was done as per the Centers for Disease Control guidelines at nine laboratories approved by the Government of Rajasthan. Data were analyzed in terms of demographic characteristics, clinical presentation and outcome. Results: Among 18,187 tested cases, 6203 (34.10%) were positive. Death occurred in 378 cases, with six per cent case fatality rate. Maximum number of cases (n=2801) and deaths (n=101) were from Jaipur zone. The highest number of cases, 47.60 per cent (2953/6203) and deaths, 52.11 per cent (197/378) were in the age group of 26-50 yr; 52.64 per cent (199/378) of deaths occurred in females. The highest number (63.5%) of deaths was from urban areas. Associated risk factors were observed in 59.44 per cent of the death cases, pregnancy being the predominant predisposing factor. In 61.92 per cent of patients, death occurred within three days of hospitalization. Interpretation & conclusions: H1N1 epidemic caused high morbidity and mortality in early 2015, particularly in the younger and middle-aged population and pregnant women in Rajasthan State of India. The study highlights the regular surveillance of influenza like illness, early diagnosis and timely initiation of therapy in suspected cases.
      Citation: Indian Journal of Medical Research 2016 144(6):918-923
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_1183_15
      Issue No: Vol. 144, No. 6 (2017)
       
  • Genetic polymorphisms of N-acetyltransferase 2 & susceptibility to
           antituberculosis drug-induced hepatotoxicity

    • Authors: Surendra K Sharma, Brajesh Kumar Jha, Abhishek Sharma, V Sreenivas, Vishwanath Upadhyay, Chandrita Jaisinghani, Rohit Singla, Hemant Kumar Mishra, Manish Soneja
      Pages: 924 - 928
      Abstract: Surendra K Sharma, Brajesh Kumar Jha, Abhishek Sharma, V Sreenivas, Vishwanath Upadhyay, Chandrita Jaisinghani, Rohit Singla, Hemant Kumar Mishra, Manish Soneja
      Indian Journal of Medical Research 2016 144(6):924-928
      Background & objectives: The N-acetyltransferase 2 (NAT2) gene encodes an enzyme which both activates and deactivates arylamine and other drugs and carcinogens. This study was aimed to investigate the role of NAT2 gene polymorphism in anti-tuberculosis drug-induced hepatotoxicity (DIH). Methods: In this prospective study, polymerase chain reaction-restriction fragment length polymorphism results for NAT2 gene were compared between 185 tuberculosis patients who did not develop DIH and 105 tuberculosis patients who developed DIH while on anti-tuberculosis drugs. Results: Frequency of slow-acetylator genotype was commonly encountered and was not significantly different between DIH (82.8%) and non-DIH (77.2%) patients. However, the genotypic distribution of variant NAT2*5/*7 amongst slow-acetylator genotypes was significantly higher in DIH (56%) group as compared to non-DIH (39%) group (odds ratio 2.02; P=0.006). Interpretation & conclusions: The present study demonstrated no association between NAT2 genotype and DIH in the north Indian patients with tuberculosis.
      Citation: Indian Journal of Medical Research 2016 144(6):924-928
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_684_14
      Issue No: Vol. 144, No. 6 (2017)
       
  • Nasopharyngeal aspirate & blood cytokine profile in infants hospitalized
           for respiratory syncytial virus bronchiolitis: A pilot study from south
           India

    • Authors: Suresh Natarajan, Ganesh Ramasamy, N Pavan Kumar, S Subash Babu, Lalitha Janakiraman
      Pages: 929 - 931
      Abstract: Suresh Natarajan, Ganesh Ramasamy, N Pavan Kumar, S Subash Babu, Lalitha Janakiraman
      Indian Journal of Medical Research 2016 144(6):929-931
      Background & objectives: Following a respiratory syncytial virus (RSV) bronchiolitis, only some infants develop serious illness, and a proportion of them develop recurrent wheeze subsequently. Studies have revealed that cytokine expression following RSV infection may influence the severity and also the risk for subsequent reactive airway disease. This present study was conducted to determine the blood, and nasopharyngeal aspirate (NPA) cytokine profile among infants admitted for RSV bronchiolitis. Methods: In this prospective pilot study, a sample size of 15 cases and 15 controls was included. Detailed history, physical examination, blood sample and NPA collection were done. Cytokines (IFNγ and IL-4) estimation was done in the blood and NPA samples of cases and blood samples of controls. Results: The mean levels of interferon gamma in controls (blood) and cases (NPA and blood) were 5.95, 9.54 and 32.02 pg/ml, respectively. The mean levels of interleukin-4 in controls (blood), and cases (NPA and blood) were 1280.77, 956.08 and 692.37 pg/ml, respectively (P
      Citation: Indian Journal of Medical Research 2016 144(6):929-931
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_1120_14
      Issue No: Vol. 144, No. 6 (2017)
       
  • Correlation of cartilage metabolic markers & antioxidants with the
           severity of knee osteoarthritis

    • Authors: Sonam Choden Bhutia, Mingma Lhamu Sherpa, SK Dewan, TA Singh
      Pages: 932 - 934
      Abstract: Sonam Choden Bhutia, Mingma Lhamu Sherpa, SK Dewan, TA Singh
      Indian Journal of Medical Research 2016 144(6):932-934
      Osteoarthritis is characterized by the degeneration of articular cartilage. Cartilage metabolic markers have been explored as possible markers for osteoarthritis, and osteogenic protein -1 (OP-1) has emerged out to play a major role in cartilage repair. Oxidative stress has been implicated as a mediator of cartilage damage in patients with osteoarthritis. The aim of this study was to correlate the cartilage metabolic markers and antioxidants with the severity of knee osteoarthritis.
      Citation: Indian Journal of Medical Research 2016 144(6):932-934
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_1235_14
      Issue No: Vol. 144, No. 6 (2017)
       
  • Echocardiographic abnormalities in cirrhosis & their correlation with
           severity of cirrhosis using Child-Pugh score among patients in a tertiary
           care hospital

    • Authors: Jagruti Balde, N Karthik Rao, Kirthinath Ballala, Jyothi Samanth, K Ranjan Shetty, Navin Patil, A Avinash, George Varghese
      Pages: 935 - 937
      Abstract: Jagruti Balde, N Karthik Rao, Kirthinath Ballala, Jyothi Samanth, K Ranjan Shetty, Navin Patil, A Avinash, George Varghese
      Indian Journal of Medical Research 2016 144(6):935-937
      Background & objectives: Child-Pugh score (CPS) is a widely used prognostic marker in cases of cirrhosis and pulmonary arterial hypertension (PAH). However, the role of this score in the quantification of severity of PAH is not well studied. In mild cases, echocardiography is more sensitive. This study was done to assess the association between echocardiography and severity of cirrhosis using CPS. Methods: A cross-sectional study was done from April to June 2014 in 42 patients with cirrhosis using a pre-tested semi-structured interview schedule. Results: There was no significant association between echocardiographic changes and CPS in patients with liver cirrhosis. Interpretation & conclusions: Advising an echocardiographic evaluation may prove beneficial in patients of Child-Pugh Grades B and C. However, more extensive studies are required to confirm the same.
      Citation: Indian Journal of Medical Research 2016 144(6):935-937
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_1486_15
      Issue No: Vol. 144, No. 6 (2017)
       
  • Mapping dengue cases through a national network of laboratories, 2014-2015

    • Authors: Vasna Joshua, Manoj V Murhekar, M Ashok, K Kanagasabai, M Ravi, R Sabarinathan, BK Kirubakaran, V Ramachandran, Nivedita Gupta, Sanjay Mehendale
      Pages: 938 - 941
      Abstract: Vasna Joshua, Manoj V Murhekar, M Ashok, K Kanagasabai, M Ravi, R Sabarinathan, BK Kirubakaran, V Ramachandran, Nivedita Gupta, Sanjay Mehendale
      Indian Journal of Medical Research 2016 144(6):938-941

      Citation: Indian Journal of Medical Research 2016 144(6):938-941
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_673_16
      Issue No: Vol. 144, No. 6 (2017)
       
  • Avian influenza A H7N9 virus infections not evident among high-risk groups
           in India

    • Authors: Shailesh D Pawar, Babasaheb V Tandale, Rashmi S Mali, Varsha A Potdar, Sadhana S Kode, Dipankar Biswas, Mandeep S Chadha
      Pages: 942 - 944
      Abstract: Shailesh D Pawar, Babasaheb V Tandale, Rashmi S Mali, Varsha A Potdar, Sadhana S Kode, Dipankar Biswas, Mandeep S Chadha
      Indian Journal of Medical Research 2016 144(6):942-944

      Citation: Indian Journal of Medical Research 2016 144(6):942-944
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_718_15
      Issue No: Vol. 144, No. 6 (2017)
       
  • Massive cerebral infarct due to Trousseau's syndrome in gastric
           cancer

    • Authors: CA Mansoor, A Jemshad
      Pages: 945 - 945
      Abstract: CA Mansoor, A Jemshad
      Indian Journal of Medical Research 2016 144(6):945-945

      Citation: Indian Journal of Medical Research 2016 144(6):945-945
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_377_15
      Issue No: Vol. 144, No. 6 (2017)
       
  • Granulomatous cheilitis with gingival enlargement

    • Authors: Pooja Arora, Arvind Ahuja
      Pages: 946 - 947
      Abstract: Pooja Arora, Arvind Ahuja
      Indian Journal of Medical Research 2016 144(6):946-947

      Citation: Indian Journal of Medical Research 2016 144(6):946-947
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/ijmr.IJMR_1950_15
      Issue No: Vol. 144, No. 6 (2017)
       
  • Autism spectrum disorders: Phenotypes, mechanisms and treatments

    • Authors: V Ashok Mysore
      Pages: 948 - 949
      Abstract: V Ashok Mysore
      Indian Journal of Medical Research 2016 144(6):948-949

      Citation: Indian Journal of Medical Research 2016 144(6):948-949
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/0971-5916.205403
      Issue No: Vol. 144, No. 6 (2017)
       
  • The importance of nutrition as an integral part of disease management

    • Authors: Namrata Singh, Anoop Saraya
      Pages: 949 - 950
      Abstract: Namrata Singh, Anoop Saraya
      Indian Journal of Medical Research 2016 144(6):949-950

      Citation: Indian Journal of Medical Research 2016 144(6):949-950
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/0971-5916.205404
      Issue No: Vol. 144, No. 6 (2017)
       
  • Panel of Reviewers (2016)

    • Pages: 951 - 968
      Abstract:
      Indian Journal of Medical Research 2016 144(6):951-968

      Citation: Indian Journal of Medical Research 2016 144(6):951-968
      PubDate: Fri,28 Apr 2017
      Issue No: Vol. 144, No. 6 (2017)
       
 
 
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