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Publisher: Medknow Publishers   (Total: 355 journals)

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Showing 1 - 200 of 354 Journals sorted alphabetically
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advances in Human Biology     Open Access   (Followers: 1)
African J. for Infertility and Assisted Conception     Open Access  
African J. of Business Ethics     Open Access   (Followers: 6)
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.269, h-index: 10)
African J. of Trauma     Open Access  
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 6)
Anesthesia : Essays and Researches     Open Access   (Followers: 8)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.331, h-index: 15)
Annals of Bioanthropology     Open Access   (Followers: 3)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.408, h-index: 15)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.308, h-index: 14)
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 7, SJR: 0.441, h-index: 10)
Annals of Saudi Medicine     Open Access   (SJR: 0.24, h-index: 29)
Annals of Thoracic Medicine     Open Access   (Followers: 4, SJR: 0.388, h-index: 19)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 15, SJR: 0.148, h-index: 5)
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Intl. Surgery     Open Access   (Followers: 9)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Pharmacy Practice     Open Access   (Followers: 6)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 3)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.879, h-index: 49)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 2, SJR: 0.362, h-index: 10)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Cancer Translational Medicine     Open Access   (Followers: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 1)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access   (Followers: 1)
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 12, SJR: 0.82, h-index: 12)
Contemporary Clinical Dentistry     Open Access   (Followers: 4)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.339, h-index: 19)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.131, h-index: 4)
Dental Research J.     Open Access   (Followers: 9)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 5, SJR: 0.205, h-index: 22)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access  
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.121, h-index: 3)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Orthopaedic J.     Open Access  
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.473, h-index: 8)
Environmental Disease     Open Access   (Followers: 2)
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.496, h-index: 11)
European J. of General Dentistry     Open Access   (Followers: 1)
European J. of Prosthodontics     Open Access   (Followers: 2)
European J. of Psychology and Educational Studies     Open Access   (Followers: 8)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.107, h-index: 5)
Genome Integrity     Open Access   (Followers: 4, SJR: 1.227, h-index: 12)
Global J. of Transfusion Medicine     Open Access   (Followers: 2)
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
IJS Short Reports     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 8, SJR: 0.302, h-index: 13)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (SJR: 0.318, h-index: 26)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.618, h-index: 16)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.307, h-index: 16)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.243, h-index: 24)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.448, h-index: 16)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 3, SJR: 0.563, h-index: 29)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.292, h-index: 9)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.53, h-index: 34)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.716, h-index: 60)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.207, h-index: 31)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.233, h-index: 12)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.213, h-index: 5)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 4, SJR: 0.203, h-index: 13)
Indian J. of Ophthalmology     Open Access   (Followers: 5, SJR: 0.536, h-index: 34)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 9, SJR: 0.393, h-index: 15)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.218, h-index: 5)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.35, h-index: 12)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 1, SJR: 0.285, h-index: 22)
Indian J. of Pharmacology     Open Access   (SJR: 0.347, h-index: 44)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.303, h-index: 13)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.496, h-index: 15)
Indian J. of Psychological Medicine     Open Access   (Followers: 1, SJR: 0.344, h-index: 9)
Indian J. of Public Health     Open Access   (Followers: 1, SJR: 0.444, h-index: 17)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4, SJR: 0.253, h-index: 14)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.169, h-index: 7)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.313, h-index: 9)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.366, h-index: 16)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 4, SJR: 0.229, h-index: 13)
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 7)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.239, h-index: 4)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.523, h-index: 15)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 7, SJR: 0.611, h-index: 9)
Intl. J. of Trichology     Open Access   (SJR: 0.37, h-index: 10)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 3)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 4, SJR: 0.427, h-index: 15)
J. of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 8, SJR: 0.416, h-index: 14)
J. of Applied Hematology     Open Access  
J. of Association of Chest Physicians     Open Access   (Followers: 2)
J. of Basic and Clinical Reproductive Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Therapeutics     Open Access   (Followers: 4, SJR: 0.359, h-index: 21)
J. of Carcinogenesis     Open Access   (Followers: 1, SJR: 1.152, h-index: 26)
J. of Cardiothoracic Trauma     Open Access  
J. of Cardiovascular Disease Research     Open Access   (Followers: 3, SJR: 0.351, h-index: 13)
J. of Cardiovascular Echography     Open Access   (SJR: 0.134, h-index: 2)
J. of Cleft Lip Palate and Craniofacial Anomalies     Open Access   (Followers: 2)
J. of Clinical and Preventive Cardiology     Open Access   (Followers: 1)
J. of Clinical Imaging Science     Open Access   (Followers: 1, SJR: 0.277, h-index: 8)
J. of Clinical Neonatology     Open Access   (Followers: 1)
J. of Clinical Ophthalmology and Research     Open Access   (Followers: 2)
J. of Clinical Sciences     Open Access  
J. of Conservative Dentistry     Open Access   (Followers: 4, SJR: 0.532, h-index: 10)
J. of Craniovertebral Junction and Spine     Open Access   (Followers: 4, SJR: 0.199, h-index: 9)
J. of Current Medical Research and Practice     Open Access  
J. of Current Research in Scientific Medicine     Open Access  
J. of Cutaneous and Aesthetic Surgery     Open Access   (Followers: 1)
J. of Cytology     Open Access   (Followers: 1, SJR: 0.274, h-index: 9)
J. of Dental and Allied Sciences     Open Access   (Followers: 1)
J. of Dental Implants     Open Access   (Followers: 7)
J. of Dental Lasers     Open Access   (Followers: 2)
J. of Dental Research and Review     Open Access   (Followers: 1)
J. of Digestive Endoscopy     Open Access   (Followers: 3)
J. of Dr. NTR University of Health Sciences     Open Access  
J. of Earth, Environment and Health Sciences     Open Access   (Followers: 1)
J. of Education and Ethics in Dentistry     Open Access   (Followers: 5)
J. of Education and Health Promotion     Open Access   (Followers: 5)
J. of Emergencies, Trauma and Shock     Open Access   (Followers: 9, SJR: 0.353, h-index: 14)
J. of Engineering and Technology     Open Access   (Followers: 6)
J. of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
J. of Family and Community Medicine     Open Access   (Followers: 2)
J. of Family Medicine and Primary Care     Open Access   (Followers: 11)

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Journal Cover International Journal of Green Pharmacy
  [SJR: 0.229]   [H-I: 13]   [4 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 0973-8258 - ISSN (Online) 1998-4103
   Published by Medknow Publishers Homepage  [355 journals]
  • Meyna spinosa Roxb.: An unexplored ethnomedicinal plant

    • Authors: Saikat Sen
      Abstract: Traditional and folk remedies are known to mankind for thousands of years and continue to be the source of new medicines in future. Meyna spinosa Roxb., belonging to the family Rubiaceae, is a promising folk medicinal plant of India. The plant is distributed in the North Eastern and Southern part of India, Bangladesh, China, Myanmar, and Malaya. This plant has a long history of use in folk medicine, especially among the different tribes and ethnic people of India. M. spinosa traditionally been used for the treatment of skin infection, headache, diabetes, hepatic disorder, dysentery, indigestion, intestinal worm, and painful urination. It is also important for its abortifacient activity. In spite of its huge ethnomedicinal use very few phytochemical and pharmacological investigations have been carried out on M. spinosa. The plant parts have been investigated for antioxidant, antimicrobial, antidiabetic, cytotoxic, hepatoprotective, and nephroprotective activity. Few flavonoids, triterpenes, phytosterols, hydroxy acid, and fatty alcohol are isolated from the plant. The present article includes details exploration of morphology, taxonomy, folk medicinal use and pharmacological and phytochemical aspects of M. spinosa in an attempt to provide a direction for future research.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1138
      Issue No: Vol. 11, No. 03 (2017)
       
  • Stability testing of Ayurvedic formulations: Exigency of today’s
           world

    • Authors: Chinky Goyal
      Abstract: The concept of stability is one of the most important issues regarding Ayurvedic formulations as till date no specific guidelines are available for the same. Although the Ayurvedic lexicon as well as Gazette notification issued by Government of India on 26th November, 2005 revealed shelf life of Ayurvedic formulations, greater advancements in packaging and storage technology nowadays has created a need for the revision of their shelf life. Mainly, two guidelines, namely, International Conference on Harmonization (ICH) and the World Health Organization provide details regarding parameters for stability study of pharmaceutical products but ICH guidelines from Q1 to Q11 is generally followed. A well-designed stability protocol containing information such as selection of batches and samples, test attributes, analytical procedures, acceptance criteria, storage conditions and period, testing frequency, sampling plan, container closure systematic, and various types of stability study and stability testing methods should be taken into consideration. Currently, pharmaceutical product is generally assayed using a validated stability indicating analytical method and an expiry date is marked based on the predicated period from date of manufacture when the pharmaceutical product would show more than 10% deterioration in the active molecule. Hence, these guidelines may also be implemented on Ayurvedic formulations where percentage degradation can be assayed when the product is stored at different conditions of temperature and humidity. The general concept of stability for Ayurvedic or modern medicine remains same but the parameters used to assess the stability may vary from product to product.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1139
      Issue No: Vol. 11, No. 03 (2017)
       
  • Treatment of Hashimoto’s thyroiditis with herbal medication

    • Authors: Prabhakar Pranav Kumar
      Abstract: Hashimoto’s thyroiditis (HT) is an autoimmune thyroid disorder, an organ-specific disease, which is characterized by diffused goiter with lymphocytic infiltration, which leads to destruction of thyroid gland causing hypothyroidism. This is a condition where the thyroid gland does not release enough of thyroid hormone called thyroxin due to the insufficient amount of iodine. Some common sign and symptoms of Hashimoto’s disease and hypothyroidism are weight gain, depression, and constipation, irregular and heavy menstrual period. However, herbal treatment is effective and enhances thyroid function. There are some natural-occurring herbs such as gum guggul (Commiphora mukul), Blue flag root (Iris versicolor), bladder wrack (Fucus vesiculosus), and seaweeds which are commonly used to treat this disorder. These herbs have different mechanism of action in HT and hypothyroidism disorder. Bladder wrack upregulate the production of iodine processing hormone, whereas gum guggul increases the conversion of tetraiodothyronine into triiodothyronine, and blue flag root is a detoxifying agent. This review article summarizes the herbal treatments which are commonly used and also their mechanism of action.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1140
      Issue No: Vol. 11, No. 03 (2017)
       
  • Asthma and chronic obstructive pulmonary disorder - phytomedicine

    • Authors: Bikram Singh
      Abstract: Asthma and chronic obstructive pulmonary disorder (COPD) are well known chronic inflammatory respiratory disease affecting millions of people worldwide. Asthma originates in childhood, is associated with allergies and related toeosinophils, whereas, COPD occurs in adults who smoke, due to involvement of neutrophils. The current allopathic system of medicine aim to alleviate symptoms rather than cure, basically these treatments includes anti-inflammatory therapy, corticosteroids, and bronchodilators. Over use of some therapies can lead to adverse effects among patients, such as pneumonia and cardiac comorbidities. Nowadays, the interest of people diverts toward the area of phytomedicine. Phytomedicine is a plant-based traditional medical practice which provides an alternative source or as an add-on therapy to the existing one. Some herbs, such as Khella and Lobelia are widely used as vasodilators and bronchodilators having no side effects. This review focuses on recent human clinical trials using plant-based medicines for treatment of asthma and COPD.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1141
      Issue No: Vol. 11, No. 03 (2017)
       
  • Natural products in treatment of rheumatoid arthritis

    • Authors: Mukta Gupta
      Abstract: Rheumatoid arthritis (RA) is a chronic, progressive, sustained inflammatory autoimmune disease associated with articular, extraarticular, and systemic effects. It is characterized by synovial inflammation, hyperplasia, leading to destruction of articular cartilage, bone erosion, and ultimately permanent deformities. Conventional treatments for RA include non-steroidal anti-inflammatory drugs, disease modifying antirheumatoid drugs, corticosteroids, and biological agents. All these therapeutic agents are associated with one or more side-effects, and none of the available treatments are able to achieve the ultimate therapeutic goal, i.e., drug-free remission. Herbal remedies are alternative source to relieve symptoms in patients having RA as well as to overcome the drawbacks associated with present treatment methods. A study conducted by the World Health Organization had reported that about 80% of world’s population relies on traditional medicine. More than 450 plants belonging to 100 families are used traditionally in management of arthritis. Some of the important natural compounds reported toexhibit anti-arthritic potential includes anthroquinone (Aloe barbadensis), with anolides (Withania somnifera), terpenes (Zingiber officinale, Boswellia serrata), polyphenols (Camellia sinensis), stilbene (Vitis vinifera, Tripterygium wilfordi). Although a number of herbal medicines are recommended for RA, further research is required to investigate their safety, efficacy, and potential drug interactions.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1142
      Issue No: Vol. 11, No. 03 (2017)
       
  • Therapeutic potential of epigallocatechin gallate

    • Authors: Navneet Khurana
      Abstract: Green tea leaves (Camellia sinensis, Family Theaceae) have been consumed in the form of beverage since long, but their widespread health benefits have been discovered relatively recently. Epigallocatechin gallate (EGCG) is a polyphenol found abundantly in these leaves. It is a potent antioxidant which helps greatly in combating the oxidative stress generated in the body during various physiological processes. Oxidative stress plays a great role in the development of various chronic diseases such as heart diseases, cancer, and neurodegenerative diseases, such as Parkinson’s and Alzheimer’s diseases. Oxidative stress is also involved in the process of aging. The oxygen radical absorbance capacity assay conducted by the US Department of Agriculture clearly signifies that brewed green tea is a potent antioxidant in comparison to majority of antioxidant rich foods, such as brewed black tea, raw kiwi, lemon juice, and extra virgin olive oil. EGCG has shown promising results in the therapy of various diseases and disorders such as cancers, fatty liver disease, HIV infection, hypertension, Type-II diabetes mellitus, obesity, and neurodegenerative diseases. Some recent studies have revealed novel actions of EGCG, such as interaction with proteins and phospholipids in the plasma membrane. This review presents a comprehensive outlook on the reported pharmacological activities of EGCG along with its green extraction method, pharmacokinetic and toxicity profiles. The data have been collected by several research and review papers obtained from various journal resources including PubMed Central and Elsevier.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1143
      Issue No: Vol. 11, No. 03 (2017)
       
  • Impact of nanotechnology on global trade of herbal drugs: An overview

    • Authors: Ganesh G. Tapadiya
      Abstract: Natural herbs are moving from fringe to mainstream use with a increase number of population-seeking remedies and health approaches free from hazardous side effects caused by laboratory synthesize chemicals. Recently, focus has been given to utilize eco-friendly and bio-friendly natural-based products for the prevention and cure of diseases. It is documented that 80% of the world’s population has belief in natural medicine, particularly plant-based drugs for their primary healthcare. Herbal drug generally introduce in the market in traditional dosage form but now different scientific approaches are being developed these days to deliver herbal medicines due to their poor rate of absorption and target specific approach. Novel drug delivery systems including nanoparticles have been developed for the effective delivery of herbal drugs. Nanoparticulate formulations such as liposomes, polymeric nanoparticles, micro-emulsions, proliposomes, and solid lipid nanoparticles present potential to deliver herbal medicines effectively. Because of nanotechnology, the use of herbal drug is greatly increased in recent years. In this article, we are try to elaborating the role of nanotechnology which increases the potential as well as sale of herbal drugs in global world.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1144
      Issue No: Vol. 11, No. 03 (2017)
       
  • Current and future prospective of liposomes as drug delivery vehicles for
           the effective treatment of cancer

    • Authors: Surajpal Verma
      Abstract: Liposomes, as the leading drug delivery system, have played a significant role in the formulation of anticancer drug to improve therapeutic effect. This system improves the pharmacokinetic and pharmacodynamic profiles of the therapeutic payload, promote controlled and sustained release of anticancer drugs, and exhibit very less systemic toxicity as compared to the free anticancer drug. The mechanism giving rise to therapeutic advantages of liposomes such as the ability of long-circulating liposomes to preferentially accumulate at disease sites such as tumors, site of infection, and site of inflammation. In the studies, liposomal anthracyclines have shown highly efficient drug encapsulation, resulting in significant anticancer activity with reduced cardiotoxicity. There are several methods for liposomes preparation based on lipid drug interaction and liposomes disposition mechanism including the incubation of rapid clearance of liposomes by controlling particle size and surface hydration. The liposomes are characterized with respect to physical, chemical, and biological parameters. This review discusses the recent advances in the preparation methods of liposome for the treatment of cancer.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1145
      Issue No: Vol. 11, No. 03 (2017)
       
  • Role of nutraceuticals in health care: A review

    • Authors: Sharma Ruchi
      Abstract: The term “nutraceuticals” can be explained as the food items as a whole or a part which possesses some nutritional value along with the medicinal properties. This special feature, besides providing good health, leads to treatment and prevention of certain diseases. With the advancements in the qualitative and quantitative determining parameters, the requisition of these products has been found to be amplified. Due to this, the nutraceutical market has become a million dollar industry at a global level. The era of emergence of nutrients as medicines in the pharmaceutical world is of great importance and draws attention of scientists and researchers toward the appreciable benefits. The history and discovery has explored many facts about the remarkably profound therapeutic activities of such agents. As a result, interdisciplinary approaches are now been applied to design and develop various dosage forms to deliver these herbal products relative to their applications. The extensive researches have revealed the involvement of these agents in the treatment of many disorders such as cancer, arthritis, metabolic abnormalities, diabetes, asthma, and many others. The presented review is an attempt to classify all types of nutraceuticals with examples followed by their applications in the treatment of various disorders. Furthermore, the implementation of the designing and development of dosage forms for offering better delivery carrier of the nutraceuticals, the importance and challenges have also been enumerated.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1146
      Issue No: Vol. 11, No. 03 (2017)
       
  • Probiotics- A new diabetes management tool

    • Authors: Pranav Kumar Prabhakar
      Abstract: Diabetes mellitus is commonly known worldwide by the name of diabetes which occurs in all age groups. About >90% of diagnosed patient specially are Type-2 diabetes. The hallmark of Type 2 diabetes developments is increased insulin resistance, whereas Type 1 is related to less production of insulin which leads to uncontrolled hyperglycemia. Hyperglycemia slowly produces mild-to-very serious complications in patient mainly affecting vital organs such as blood vessels, eyes, neurons, nephrons, heart, and brain which increase the risk of heart attack, retinopathy, nephropathy, neuropathy, and stroke. Proper management of hyperglycemia is a key to prevent from diabetes and its complications. This concept has attracted many researchers to target various cells and tissue through special remedy so that hyperglycemia can be managed and complications can be reduced. The patient shows numerous side effects during therapy. There is craving demand for the proper cure of diabetes by sufferers. In this aspect, probiotics can be more helpful if proper research and formulation are done. Probiotics are good microorganism which can control hyperglycemia and its complications by utilizing and modifying glucose before absorption. Appropriate research is required to make strategy for searching and formulating good microorganism to be used as probiotics for the regulation of blood glucose and prevention from complexity.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1147
      Issue No: Vol. 11, No. 03 (2017)
       
  • Shalmali (Bombax ceiba): Versatility in its therapeutics

    • Authors: Vandana Meena
      Abstract: The medicinal plants are widely used by the traditional medical practitioners for curing various diseases in their day-to-day practice. Shalmali is a well-known plant used in the traditional system for treatment of many diseases. The therapeutic activity of Shalmali is partly due to the presence of flavonoids, phenolics, sesquiterpenoids, shamimicin, bombamalosides, bombamalones, bombasin, bombasin 4-o-glucoside, and bombalin. In the present review, efforts have been made to recapitulate different aspects of scientific studies on the Shalmali such as ethnopharmacology, phytochemistry, and mainly the pharmacological activities. In vitro and in vivo studies, for various pharmacological activities of the Shalmali, for example, antioxidant, antimicrobial, anticarcinogenic, anti-inflammatory, immunemodulatory, hypotensive, hypolipidemic, antihyperglycemic, and analgesic have been demonstrated.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1148
      Issue No: Vol. 11, No. 03 (2017)
       
  • Nutritional and medicinal properties of Korean cedar cones and seeds in
           Russian Far East

    • Authors: Natalya G. Rozlomiy
      Abstract: Cedar-broadleaf forests developed by Korean cedar (Pinus koraiensis Siebold et Zucc.) are the most ancient and most valuable forest formation of the Far East. More than half of these forests areas and reserves are located in Primorsky Krai, where multidimensional works are carried out during the past decades to restore its range and timber reserves. This is due to the fact that all parts of this relic species (needles, wood, cones, seeds, etc.) have different medicinal properties, which were well known to local people and were used to treat many diseases.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1149
      Issue No: Vol. 11, No. 03 (2017)
       
  • Protective potential of royal jelly against hepatotoxicity

    • Authors: Sazal Patyar
      Abstract: Objective: The objective is to study the hepatoprotective effect of royal jelly (RJ) against antitubercular drug-induced hepatotoxicity in rats. Materials and Methods: A total of 30 Wistar albino rats of either sex were divided into five groups (n = 6): Group I - Vehicle control (gum acacia, 1%), Group II - combination of isoniazid (H), rifampicin (R), and pyrazinamide (Z) (H + R + Z suspension – 27 + 54 + 135 mg/kg), Group III - H + R + Z suspension (27 + 54 + 135 mg/kg) + RJ (50 mg/kg), Group IV - H + R + Z suspension (27 + 54 + 135 mg/kg) + RJ (100 mg/kg), and Group V - H + R + Z suspension (27 + 54 + 135 mg/kg) + silymarin (50 mg/kg). The animals were treated for 30 days with H + R + Z suspension and the test group was concomitantly administered RJ. After 30 days, the animals were sacrificed for the investigation of morphological, histopathological, and biochemical parameters. Results: Antitubercular drug-induced hepatotoxicity was successfully reproduced. Concurrent administration of RJ along with antitubercular drugs significantly prevented the rise in levels of serum alanine aminotransferase, serum aspartate aminotransferase, and tissue malondialdehyde. Administration of RJ reduced inflammation, degeneration, necrotic changes in hepatocytes and significantly prevented fall in superoxide dismutase as compared to the group receiving antitubercular drugs alone. Conclusion: RJ is an effective hepatoprotective agent and prevented the antitubercular drug-induced hepatotoxicity.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1150
      Issue No: Vol. 11, No. 03 (2017)
       
  • Evaluation of nootropic activity of Sida cordifolia in mice

    • Authors: Navneet Khurana
      Abstract: Introduction: In the present study, nootropic effect of aqueous and hydroethanolic extracts of Sida cordifolia (AESC and EESC, respectively) was investigated in mice using transfer latency (TL) and step-down latency (SDL) tests. S. cordifolia is a well-known Ayurvedic plant which has been administered anciently for the various nervous disorders including loss of memory. Materials and Methods: Varying doses (50, 100, 250 mg/kg; p.o.) of AESC and EESC were administered along with standard drug (donepezil; 5 mg/kg) for 15 successive days to different groups. They were subjected TL and SDL tests on the 16th day. Results: EESC dose dependently increased the SDL and decreased the TL in mice as compared to control group, and this effect was comparable to the standard drug. No significant effect on TL and SDL was observed following varying dose treatment of AESC. Conclusion: These findings suggest the nootropic effect of EESC and predict its scope in the possible treatment of diseases associated with memory dysfunctions such as Alzheimer’s disease
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1151
      Issue No: Vol. 11, No. 03 (2017)
       
  • Design, synthesis and antibacterial evaluation of pyrano[3,2-H]quinoline
           carbonitriles

    • Authors: Sravanthi Siliveri
      Abstract: Aim: To synthesize novel pyrano quinolines by one-pot multicomponent reaction under noncatalytic conditions, further it was proposed to investigate the reactivity of pyrano quinolines with the oxidizing agent like iodobenzene diacetate (IBD). Synthesized compounds were evaluated for antibacterial activity. Materials and Methods: Synthetic procedure: A mixture of aldehyde (1 mmol), malononitrile (1 mmol) in 10 ml of ethanol-water (1:1) was stirred for 10 min and then followed by addition of 8-hydroxy quinoline (1 mmol) and refluxed at 100°C for 1-2 h. The precipitated solid was collected by filtration. In the next step, to a suspension of pyrano[3,2-h]quinoline carbonitrile (1 mmol) in 5 mL of alcohol was added IBD (1.1 mmol) with stirring at room temperature open to air. The reaction mixture immediately became a clear solution followed by the precipitation of the product. The mixture was filtered and washed with the corresponding alcohol to afford the desired product. Antibacterial activity: All the synthesized compounds were screened for antimicrobial activity at a concentration of 100 μg/50 μl using ciprofloxacin as a standard drug. The minimum inhibitory concentrations (MICs) of these compounds were determined using broth microdilution MIC method. Results and Discussion: Synthetic studies: At the outset, pyrano[3,2-h]quinoline carbonitrile analogs 1(a-j) were constructed by a catalyst-free protocol via a one-pot, three-component condensation. Further, catalytic oxidative difunctionalization of the chromene double bond was achieved using hypervalent iodine reagents such as IBD in alcoholic medium and total 14 novel compounds 2(a-k) have been synthesized and confirmed on the basis of spectral data (infrared, nuclear magnetic resonance, and mass). Antibacterial activity: Among all the tested compounds, 1g, 1h, 1j, 2d, 2f, 2h, and 2k showed antibacterial activity against both Gram-positive and Gram-negative standard strains, and their MICs ranged between 1.56 and 12.55 μg/mL. Conclusion: In summary, an efficient, economical and eco-friendly multicomponent protocol for the construction of pyrano[3,2-h]quinoline carbonitriles has been achieved, and an oxidative difunctionalization of chromene double bond has been studied in the alcoholic solvent medium in the presence of IBD.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1152
      Issue No: Vol. 11, No. 03 (2017)
       
  • Molecular genetic tagging of wheat varieties genes resistant to Septoria
           tritici in northern Kazakhstan

    • Authors: Sandukash A. Babkenova
      Abstract: Aim: The aim of the research was to isolate sources of wheat resistance to Septoria tritici and identify genes that provide resistance to this disease based on the methodology common for phytopathological and molecular genetic studies. Materials and Methods: During the study, 303 spring wheat varietiesof different ecological and geographical origin were screened. At this, 36 samples resistant to S. tritici were isolated at the artificial infectious background. Results: In consequence of molecular genetic tagging of resistance genes in 36 varieties of wheat, it was determined that the majority of the analyzed samples carried in their genotype resistance genes ineffective to S. tritici. Just resistance gene Stb2 was characterized by the moderate efficiency. Among the studied varieties with this gene, eight samples were identified: Strain 36/12-1, Laban, GN06600, MN 94382, SD 80-89, Roblin, Yesaul, and Nota. Field resistance against the disease can be provided by varieties with a large number of resistance genes, such as Laban and Krabat. Varieties of gene Stb8 with efficient resistance to the S. tritici pathogen are of the greatest interest for selection for immunity to S. tritici. Conclusion: In consequence of the conducted research, two varieties of Laban and A.C. crystal with an effective resistance gene Stb8 were identified. These varieties should be used in breeding process as resistance donors to S. tritici.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1153
      Issue No: Vol. 11, No. 03 (2017)
       
  • Preparation and characterization of PLGA loaded nanoparticles obtained
           from D. melanoxylon Roxb. leaves for their antiproliferative and
           antidiabetic activity

    • Authors: Harun Al Rashid
      Abstract: Introduction: Diospyros melanoxylon Roxb. is traditionally used medicinal plant. Previously, we confirmed the better antiproliferative and antidiabetic activity of ethyl acetate fractions (EAF) obtained from D. Melanoxylon. To assessment the hypothesis if nanoparticle-encapsulated fraction could progress bioactivity. Materials and Methods: We prepared nanoparticle encapsulation based on poly (lactide-co-glycolide) (PLGA) and confirmed encapsulation by scanning electron microscopy. Sub EAF (SEAF) and nanoparticles of sub ethyl acetate (NSEAF) were characterized for their antiproliferative and antidiabetic activity. Antiproliferative activity was performed using the methylene blue assay. Antidiabetic activity was performed on the basis of α-amylase and α-glucosidase assay. Results and Discussion: Comparatively, NSEAF showed better activity on different cancerous cell lines HCT116 (inhibitory concentration 50% [IC50] 32.89 ± 1.71 μg/ml), MCF-7 (IC50 36.13 ± 0.96 μg/ml) and PC-3 (IC50 32.39 ± 1.91 μg/ml), and antidiabetic activity on the basis of α-amylase (IC50 35.62 ± 2.56 μg/ml), and α- glucosidase (IC50 73.52 ± 1.13 μg/ml) action at a dose-dependent manner. It is also demonstrated that NSEAF exerted very low toxic effect against normal cell lines. Conclusion: For this reason, NSEAF studied in the present research may be considered as possible future drug candidates for the treatment and management of cancer and diabetes
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1154
      Issue No: Vol. 11, No. 03 (2017)
       
  • Evaluation of solanaceous crops source material for resistance to abiotic
           factors

    • Authors: Nadezhda V. Kotsareva
      Abstract: Aim: The results of the evaluation of the solanaceous crops source material for resistance to abiotic factors are presented. A number of studies are conducted on the development and improvement of rapid methods for assessing the source material: laboratory-based method for evaluation of solanaceous crops’ cold resistance and salinity tolerance due to changes of the intensity of seeds germination under the effect of unfavorable factors (reduced positive temperatures and salinization) and for evaluation of drought resistance due to water-retaining capacity and water restoring ability of tomato leaves. Materials and Methods: The basis of the method for establishing salt tolerance is standard method for determining the germination, where along with the germination of seeds in the water, the option of cultivation of samples on selective backgrounds (with high levels of salinity) their parallel germination in saline solutions is introduced. To determine cold resistance was used high-quality collection of seeds of sweet pepper, bitter pepper, and eggplant with a high germination, same year, and place of reproduction. Results and Discussion: The results of determination of cold resistance of collection samples in the laboratory confirmed the existence of correlation dependence of “cold resistance” and “earliness” signs for sweet pepper and eggplant (r = −0.58 ± 0.15 and r = −0.62 ± 0.14, respectively) as well as signs of “cold resistance” and “the presence of anthocyanin coloration” for eggplant (r = −0.65 ± 0.15). While creating a valuable breeding material of tomato to a certain extent, the research on water holding and water recovery capacity of leaves during their most sensitivity to lack of water in the flowering stage can be used. It is found that the majority of varieties have quite high (80.1-85.0%) level of water content in the leaves. The tendency of the maximum water content in the leaves of the well-leafy varieties, which were withdrawn in the Southern Regions, is noted. A significant difference in the parameters of drought resistance of tomato plants, the maximum expression of the indicator - 83.9 ± 1.7, the minimum - 56.1 ± 1.3 is found. Indicators of high drought tolerance were detected in breeding varieties of Moldova, Southern Russia, and Southern Ukraine.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1155
      Issue No: Vol. 11, No. 03 (2017)
       
  • Statistic evaluation of food security of Russia

    • Authors: Tatyana G. Khramtsova
      Abstract: Aim: The aim of article is to presents one of aspects of food security: Provision of accessibility of food products for the population. Materials and Methods: Carrying out of analysis of dynamics of production of major agricultural products, giving an assessment of extent to which norms of rational consumption and availability of products for the population; simulation of indexes of production and volume of private consumption of certain foods has been carried out. Result: Revealing of certain problems in the sphere of provision of economic and physical availability of food products for the population of the country. Representing regional approach to assessment of problem of provision of food security. Conclusion: Offering to use indexes of localization of agricultural indications is done for assessment of food security which allowed to make assessments about regional differentiation of food security level
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1156
      Issue No: Vol. 11, No. 03 (2017)
       
  • Morphofunctional parameters of erythrocytes in blood of chickens at
           adaptation to different light status

    • Authors: Lyudmila K. Buslovskaya
      Abstract: Aim: The aim is to study the dynamics of morphofunctional parameters of erythrocytes in the process of chickens adapting to the changes in light status. Materials and Methods: Atomic force microscopy was used in the study to find out changes that were primarily related to the ability of cells to deform in various light conditions. Result and Discussion: This study revealed a reduction in the size of erythrocytes due to the depth and width of the paranuclear area, as well as a fall in the stiffness of cell membranes that indicate changes in contact and elastic properties of cellular structures, which provide oxygen transport by the blood and microcirculation.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1157
      Issue No: Vol. 11, No. 03 (2017)
       
  • Comparative infrared spectra analysis of one territory soil humic acids by
           IR-EXPERT computer system

    • Authors: Yu. M. Deryabina
      Abstract: Background and Objective: Humic acids (HAs) extracted from different soils of the Western Tuva have been studied using infrared-EXPERT information-analytical computer system and database. Methods: A total of 10 samples of HA were extracted from the humic horizon of some modern soils of the Western Tuva according to standard methods. Results: The most similar spectral analogs, their structures, and structural fragments of the HA have been identified and compared with those, which had been investigated earlier. Conclusion: Analysis of the obtained 10-node fragments showed that all HAs contain a linear, weakly branched, conjugated chains of double C-C-bonds. HA of mountain chestnut soils, with high probability, contains fragments of aromatic amines and amides.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1158
      Issue No: Vol. 11, No. 03 (2017)
       
  • Chemical study of the composition and quantitative analysis of
           hydroxycinnamic acids in experimental samples of propolis

    • Authors: Elena T. Zhilyakova
      Abstract: Background and Objective: This article presents the results of the determination of hydroxycinnamic acids in 6 experimental propolis samples. Using reversed-phase high-performance liquid chromatography in a gradient elution mode is able to identify hydroxyl and cinnamic acids by comparing retention times of analytes, the standard samples and the corresponding acids according to the results of diode-matrix detection. Method: Six prototype propolis samples from different regions of Russia were taken as research objects. From the experiment, samples were prepared extracts by 80% ethanol extraction, according to the traditional production scheme of tinctures in a ratio of 1:10. It was found that the composition of propolis has a stable set hydroxycinnamic acids comprising about 6 components: Trans-p-coumaric, ferulic, isoferulic, caffeic, 3,4-dimethyl caffeic and cinnamic acids. The internal normalization method calculates the specific weight of each of the components within the specified group. Results: It has been established that about 90% of all oxycinnamic acids are trans-para-coumaric, ferulic, and caffeic acids with a predominance of the first. The quantitative content of the dominant hydroxycinnamic acids in propolis prototypes was determined by the absolute calibration method. The content of trans-para-coumaric acid was in the range 1.43-2.1%; ferulic acid - 0.93-1.6%; and caffeic acid - 0.193-0.44%. Conclusion: The results of the conducted experiments make it possible to recommend an assessment of the quality of propolis by any of the dominant acids.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1159
      Issue No: Vol. 11, No. 03 (2017)
       
  • Biological resources of the Hyssopus l on the south of European Russia and
           prospects of its introduction

    • Authors: Elena V. Dumacheva
      Abstract: Background and Objective: The south of European Russia (geographically - the southern part of the Central Russian Upland) has large biological and plant genetic resources. There is a concept considering the region as the second anthropogenic microgen center of formation of economically valuable plants. In the south of the Central Russian Upland, the genus Hyssopus L. is represented by two species: Hyssopus cretaceus Dubjan. and Hyssopus officinalis L. We accomplished the study of biological resources of species of the genus Hyssopus L. in vivo and in vitro. Several geobotanical expeditions were carried out to identify local, stable in space and time, self-renewal cenopopulations of the species Hyssopus L. which have a number of economically useful traits. Methods: There were revealed vast populations of the species H. Cretaceous Dubjan in Belgorod region, particularly in Alexeyevsky disrtict. The frequency of occurrence of the species amounts 26.7%, and on the, especially, protected natural territory of the tract Varvarovka it can reach 75.0%. The species H. cretaceous Dubjan. is also distributed on chalky slopes of the river basins Quiet Pine (Tichaya Sosna), Black Kalitva (Chernaya Kalitva), Aidar, and Demina. With the aim of introducing, and reintroducing, as well as the industrial production of raw materials there was created a collection of valuable ecotypes of H. cretaceous Dubjan. in vitro. Results: The vast population of H. officinalis L. was found on the slopes of the Oskol River near the villages Lower and Upper Lubyanka of Volokonovsky district of Belgorod region. The starting material of the wild population formed the basis for the creation of a new hybrid of H. officinalis L. – Volokonovsky. The hybrid is suitable for commercial seed growing. Seed productivity of the hybrid Volokonovsky is more than 350 kg/ha. Conclusion: As a result of the completed research, there was created a new hybrid of H. officinalis L. - Volokonovsky. The hybrid has high-seed productivity, potential melliferous capacity, and good decorative properties. It is suitable for using as a plant for the green building, as well as for commercial seed growing.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1160
      Issue No: Vol. 11, No. 03 (2017)
       
  • Evaluation of the effectiveness of complex therapy with the inclusion of a
           prebiotic in children with non-alcoholic fatty liver disease and excess
           body weight

    • Authors: Margarita M. Gurova
      Abstract: Aim: The present study aimed to evaluated the effectiveness of complex therapy of non-alcoholic fatty liver disease (NAFLD) with the inclusion of prebiotic lactulose on the functional state of the liver, biliary tract, intestinal microbiota, lipid and carbohydrate metabolism in 54 adolescents with excess body weight and insulin resistance (IR). Materials and Methods: The diagnosis of NAFLD was established based on the accepted criteria of ultrasound examination. Result and Discussion: Ultrasound criteria typical for liver steatosis were detected in 48% of cases, along with signs of steatosis of the pancreas and violations of the motor function of the biliary tract in 70% of patients. Conclusion: It has been shown that the combination of prebiotic with insulin sensitizer metformin contributes to a greater decrease in body weight, in the manifestations of steatosis of the liver and pancreas, normalization of the state of the intestinal microbiota, a decrease in IR, a level of triglycerides compared to monotherapy with metformin
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1161
      Issue No: Vol. 11, No. 03 (2017)
       
  • Orenburg Region soil and vegetation complex pollution risk evaluation

    • Authors: I. V. Efremov
      Abstract: Aim: The objective of the present study to find out the heavy metal accumulation in steppe landscapes soils and vegetation. Materials and Methods: On imitating modeling basis, the dependence of heavy metals in “soil-plant” system preferential distribution on their subsystems transition intensity was obtained. Result and Discussion: On the basis of experimental data system contamination risk analysis, a major percentage of soil trace elements accumulated in the plant root system with lowest pollution elements in aboveground parts. Conclusion: Based on the changes in soil-plant absorption capacity, different percentage of heavy metal migrates above and underground part of vegetation. The proposed method of analysis will help in the future environmental pollution risks evaluation studies
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1162
      Issue No: Vol. 11, No. 03 (2017)
       
  • Features of morphology and biology of broad bean samples in the south of
           the central black earth region (Russia)

    • Authors: Yulia N. Kurkina
      Abstract: Background and Objective: Studied morphobiological features of collection varieties of broad beans in the conditions of the South of the Central Black Earth Region (Russia): The duration of the growing season; level seed production and its components; biochemical composition of seeds; structure of microbial interactions in the rhizosphere; and relation to pathogens. Materials and Methods: In field experiments 2014-2016, the first reproduction seeds of 24 varieties, were cultivated according to the requirements of the zonal farming. It was revealed early-maturing, high-yielding varieties with large seeds, and high protein. Were determined the parameters of a promising variety of broad beans and were revealed indirect signs of high-protein and productivity when working with initial material. On average, the vegetation period of broad bean lasted 89 days. The duration of the periods before the seedling and after flowering was highly correlated with the duration of the vegetation period (r = +0.61 and r = +0.87, respectively). The seed weight per plant was significantly correlated with the number of bean per plant (r = +0.8) and the number of pods on the lateral stem (r = +0.68). Results: The averaged correlation was observed for the seed weight per plant and the number of producing lateral stem (r = +0.42), the number of productive nodes of the main stem (r = +0.54), the number of inflorescences per plant (r = +0.36), number of inflorescences of lateral stem (r = +0.39). The number of seeds per pod was negatively correlated with the number of pods per plant (r = −0.46). The pod size was negatively correlated with the number of bean per plant (r = −0.54). Protein content of the broad bean seeds is 18-33%. An indirect indicator of the high protein content of the seeds can be served as “the number of nodes on the main stem” with the inverse relationship (r = −0.4) and “the weight of 1000 seeds” with a positive relationship (r = +0.7). Conclusion: The study of the initial material of broad beans in the soil and climatic conditions of the Belgorod region made it possible to identify a group of early ripening, with the fastest formation of pods.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1163
      Issue No: Vol. 11, No. 03 (2017)
       
  • The study of the elemental composition of humic acids of sapropels of
           lakes of the upper and Middle Priobye of West Siberia

    • Authors: M. P. Sartakov
      Abstract: Background and Objective: For the first time, the elemental composition of humic acids (HA) of sapropel of lakes of the Middle Priobye and the southern Ob-Irtysh basin of West Siberia, formed in different hydrothermal and environmental conditions. Specific features of their elemental composition that are evident in the content of elements, the atomic relations, and the degree of oxidation, indicating the ratio of aromatic and aliphatic parts, and the conditions in which the process of humification carries have been identified. HA of sapropels of the Novosibirsk region is almost two times higher than nitrogen content of HA of sapropels of Khanty-Mansiysk Autonomous Okrug. Materials and Methods: It is established that HA of sapropels of the southern part of West Siberia have the relations H/C vary from 0.83 to 1.19, and in the Middle Priobye vary from of 0.87 to 1.24, that argues for the less degree of aromaticity (or “benzoidnost” in Russian) (α), the “maturity” of macromolecules in the taiga region. Results: The found values of the degree of oxidation ω indicate that HA of sapropels have restored form and a negative value of ω with the exception of HA of sapropels of some lakes of the Middle Priobye, where there are also the oxidized forms and the positive values of ω. The results can be used for large-scale evaluation of sapropel fields, serve as a source of information for producing humic preparations. Research is needed to develop technology of production of new products for agriculture, medicine, and technology. Principles of analysis of HA can be used by students, young professionals, teachers, and researchers in scientific research institutes, universities. Conclusion: Thus, we can assume based on the study of the elemental composition of HA of sapropels of lakes of the Middle Priobye and south of the Ob-Irtysh basin of West Siberia, that their composition and properties are caused to some extent not only by hydrothermal conditions and typology of lakes but also the type of anthropogenic load, the influence of oil production in the northern region.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1164
      Issue No: Vol. 11, No. 03 (2017)
       
  • Comparative characteristics of productivity elements among film and
           huskless forms of oat

    • Authors: Magharamov Bashir Gadisovich
      Abstract: Background and Objective: The study of comparative agrobiological characteristics of productivity elements and their conjugation among various sort samples of huskless and filmed forms of oats were carried out under the conditions of the Republic of Dagestan. In the Republic of Dagestan, oat is one of the promising grain fodder and fodder crops. The interest in this culture is explained by high feed qualities of grain, vegetative mass, and protein content. Besides, oat grain is an indispensable food for most types of farm animals and poultry. A particular importance is given to the huskless forms since their grain has great prospects during the production of mixed fodders, dietary, and baby food. Methods: A comparative study of film and huskless forms of oats according to the structural elements that determine the productivity of heads revealed an actual homogeneity according to these indices, which indicates the selection potential of huskless forms. The revealed lag by the weight of 1000 grains points to the need for further study of huskless forms diversity to identify large-grain donors. Results: The study of correlation links showed that the main structural elements of head productivity, of which the final result is developed, that is, a crop, closely interact with each other positively. The revealed negative interrelationships of 1000 grain weight with the head length and the number of grains among huskless oats confirm our conclusion about the expediency of breeding-valuable genotypes search and selection according to this feature. Conclusion: AS-7 was revealed among the studied varieties of oats and among film forms in terms of productivity, and Aldan among huskless forms, both from Kemerovo region.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1165
      Issue No: Vol. 11, No. 03 (2017)
       
  • The approaches to the choice of starting antibacterial agents in patients
           with diabetic foot syndrome undergoing inpatient treatment in St. Joseph
           Belgorod Regional Clinical Hospital

    • Authors: Tatyana N. Malorodova
      Abstract: Background and Objective: Persistent ulcers in patients with diabetic foot syndrome in 85% of cases lead to amputation because of secondary infection and growing gangrene that significantly worsen the prognosis. Methods: It was found, that in patients with diabetic foot infection dominated Gram-positive microorganisms (62.7%). It was detected Staphylococcus aureus (23.4%), Staphylococcus spp. (25.8%), and Enterococcus spp. (14.5%). Among the Gram-negative aerobes, Pseudomonas spp. was the more frequently isolate (14.5%). Enterobacteriaceae were detected in 18.5% cases. Candida spp. was isolated in 1.6% cases. It was dominated Gram-positive cocci in Wagner Grade I-III: S. aureus was isolated in 36.34% - 23.89% cases; Staphylococcus spp. was detected in 22.22% - 28.94% cases; Enterococcus spp. was determined at 8.33% - 18.5% cases in Wagner Grade IV and V was found increased amount Gram-negative rods from 39.18% tо 63.63%, respectively. It was presented Enterobacteriaceae spp. and Pseudomonas aeruginosa. Results: The analysis of antibiotic susceptibility of Gram-positive strains recorded increase of resistance to oxacillin in isolated strains of Staphylococcus spp. (S. aureus and coagulase-negative staphylococci) from 25% to 100% in Wagner Grade I and V, respectively. In Wagner Grade IV and V was detected Enterobacteriaceae producing extended spectrum beta lactamase in 75% (Escherichia coli, Klebsiella pneumoniae, and Citrobacter diversus) and 83.3% (E. coli, Proteus vulgaris, and K. pneumonia) cases, respectively. Studying the P. aeruginosa sensitivity to antibiotics in Wagner Grade IV and V was registered decrease susceptibility to ceftazidime in 36.36% and 0%, meropenem in 85.7% and 50%, levofloxacin in 68.18% and 50%, ciprofloxacin in 54.54% and 50%, and amikacin in 42.7% and 33.3%, respectively. Conclusion: It is discussed the approaches to the choice of starting antibacterial agents depend on the structure of pathogens and their sensitivity to antibiotics in patients with diabetic foot ulcers with different Wagner grades in patients with diabetic foot syndrome undergoing inpatient treatment in St. Joseph Belgorod Regional Clinical Hospital.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1166
      Issue No: Vol. 11, No. 03 (2017)
       
  • The state of monocultures in the territory of green zones of vladivostok
           agglomeration (the program “Big Vladivostok”)

    • Authors: Natalya G. Rozlomiy
      Abstract: Aim: The article presents the taxation data and the description of artificially created cultures, such as Manchurian walnut, Manchurian ash, Amur cork tree, Maximovich poplar, Korean pine, and common pine. The analysis of growth of these wood species was made. The existing cultures of woody species were created in the late 1960s and early 1980s. Materials and Methods: A total of 40 sampling areas within the boundaries of green zones of “Big Vladivostok” cities were laid down for the analysis of the growth of different woody species. Results: No young growth found from plantations of forest culture in close proximity to the cities. Primarily, in the first class of the planting age, they have the III Class of growth. With further growth, the bonitet rises to I and the II Class. Conclusion: The analysis of the growth of the studied woody species, growing in different geobiological conditions, testifies to the high energy of their growth, by every taxation measure; therefore, given species can be recommended for the creation of environmentally sustainable green belt.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1167
      Issue No: Vol. 11, No. 03 (2017)
       
  • The monitoring of the irregular disturbances in the arctic on the basis of
           the processing data of the distributed network of the geophysical
           observatories

    • Authors: Oleg R. Kuzichkin
      Abstract: Background and Objective: The article discusses a data processing method for geomagnetic field of the earth on a distributed network of geophysical observatories. Method: The proposed method allows to detect and monitor irregular disturbances of the geomagnetic field, evaluate their options, determine the epicenter of the occurrence of disturbances and to estimate the parameters of the epicenter. For monitoring irregular disturbances in the Arctic the application of the developed method would prevent the effects of strong magnetic storms and substorms: Failure of cable lines, railway, accidents and damage to transformers, electronic equipment, and other ground-based technological systems. The article the effect of magnetic substorms on technical objects and biosphere of the Arctic area also examines, the organization of monitoring of geomagnetic disturbances describes, the mechanism of advanced and distributed processing irregular disturbances describes. Results: The results of approbation of the proposed methods and algorithms on a real example are this article. Conclusion: The application of the developed approaches allowed to increase the precision of determining the epicentral zone, the direction of the propagation and the intensity of geomagnetic disturbances. In addition, the ambiguity of the definition of the epicenter is completely gone, all other local extrema of the value of the correlation coefficient are not >0.78. At the same time, in the processing, the possible loss of the measuring point is due to a preselection of informative areas on them, by the primary processing of geomagnetic waves.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1168
      Issue No: Vol. 11, No. 03 (2017)
       
  • Hydrologic and hydrochemical condition of the mid-Caspian Sea

    • Authors: Sakinat A. Guseinova
      Abstract: Background and Objective: The author surveys the research papers investigating the differences in the temperature and salt levels in the sea and ocean waters depending on the space-time factors as well as rivers inflow. These differences are explained by the fact that ocean and marine areas have a high density of biological resources, as well as an anthropogenic load. Methods: Current data on the hydrochemical condition of the mid-Caspian Sea as a whole and its individual regions allocated to the exploration and development of oil fields show that this condition is formed mainly under the influence of natural processes. Results: Analytically defined silicon form in sea water is metasilicon acid. Except the dissolved state, silicon is in sea water in the form of colloidal solutions of polysilicon acids. Variability of silicon concentration in natural waters generally depends on processes of diatomic seaweed activity and its destruction. Conclusion: The author concludes that the hydrochemical condition of the marine environment within the range of inherent fluctuations does not hamper the development of oil fields on the Caspian shelf.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1169
      Issue No: Vol. 11, No. 03 (2017)
       
  • The climatic factors, determining the biological diversity of the middle
           Caspian Sea and coastal ecosystems, the atmospheric-synoptic processes,
           commotions and currents

    • Authors: Sakinat A. Guseinova
      Abstract: Background and Objective: The main climatic factors and atmospheric-synoptic processes, determining the biological diversity of the middle Caspian Sea and coastal ecosystems, are outlined. The characteristic features of the wind pattern and the currents are described. The characteristics of commotions, allowing to determine the extreme values of wave elements, are provided. That is necessary for the development of oil and gas deposits on the shelf. Method: The features of climate formation, atmospheric-synoptic processes, commotions and currents of the Caspian Sea, are given according to the information, described in numerous scientific publications and reference books, and also according to the Dagestan Center for Hydrometeorology and Environmental Monitoring. Results: The peculiarities of climate formation, atmospheric-synoptic processes, commotions and currents of the Caspian Sea, affecting the biological diversity of the middle Caspian and coastal ecosystems, are determined by the geographic position of the sea, the conditions of atmospheric circulation, the nature of the underlying surface, and the orography of the coasts. Conclusion: Assessment of the main climatic factors of atmospheric-synoptic processes, peculiarities of the wind regime, characteristics of currents, commotions, extreme values of wave elements, determining the biological diversity of the middle Caspian and coastal ecosystems, is necessary for the development of oil and gas deposits on the shelf
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1170
      Issue No: Vol. 11, No. 03 (2017)
       
  • Development of the pharmacological product identification system with
           guaranteed reliability

    • Authors: Irina V. Spichak
      Abstract: Background and Objective: The article is a considerate system, designed for marking and the identification of goods and the subsequent monitoring of their movement. The system designed to provide a guaranteed authenticity of the markings applied to a controlled product. The system’s reliability is based on the principles of symmetric and asymmetric key encryption and on “point-to-point” encryption of the markers, as well as on the technology of a secure communication channel. Materials and Methods: The article considers an algorithm for creating an encrypted token and transmitting data over closed channels. Special attention is paid to the key formation with the special PBKDF2 library, the generation of 512-bit hashes according to the GOST R 34.11-2012 and the subsequent formation of a symmetric cipher GOST R 34.12-2015. This encryption algorithm allows to view the marker on the medicine package as an encrypted message in the precision time protocol. The author also considers the use of encrypted secure sockets layer and transport layer security protocols when communicating between client devices and infrastructure devices that provide the functioning of a monitoring system. Results: In addition, the article highlights the federal grain inspection service Federal State Information System for Monitoring the Movement of Drugs (FSIS MMDP) system which is created by the Federal Service for Supervision in Health Care, its organizational and legal base and the possibility of integration of these systems. Conclusion: As a result of the research it was established that protocols for data exchange and coding of markers, which allow to make reliable operation of the system for monitoring the movement of medical products and to design a unified system for monitoring the movement of goods, or the definition of their owner and also the study showed possible vulnerabilities of the system FSIS MMD.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1171
      Issue No: Vol. 11, No. 03 (2017)
       
  • Ensuring a rational nature management in the transition of land use onto
           the basin principles and organization of large nature protection areas

    • Authors: Yulia V. Yudina
      Abstract: Background and Objective: It is proposed to use the basin concept of organization of the territory as a preliminary stage of a detailed design of the functional zoning of the natural park. The principles of creating natural parks are substantiated. Materials and Methods: The projects for basin nature management in the Vorskla and Gotnya river basins in the Belgorod region were implemented within the framework of the concept of the basin nature management, which was approved by order of the Government of the Belgorod Region No. 166-rp dated 27.02.2012. Results: The project works on the basin-based nature management and functional zoning of the natural park were carried out on the basis of integration of geoanalytical procedures with spatially distributed information using ArcGIS. The developed measures will improve the ecological stability of the area of the river Vorskla and the River Gotnya, and in the natural park «Hotmyzhsky» the following functional zones have been created: Reserved, specially protected, recreational, cognitive tourism, protection of historical and cultural sites, servicing of visitors, and economic purposes. Conclusion: The application of basin principles of organization of the territory allows optimizing the structure of the land resources of the territory, improving its ecological stability, and outlining the main functional zones, among which may include nature parks.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1172
      Issue No: Vol. 11, No. 03 (2017)
       
  • Chemical composition of biotite from the Lar Cu-Mo prospect igneous rocks,
           Southeastern part of Iran

    • Authors: Rahele Moradi
      Abstract: Background and Objective: The Lar Cu-Mo prospect is located in Sistan suture zone, southeast of Iran. In this study, the chemical composition of biotite is determined using electron probe micro-analyzer in shoshonitic igneous rocks. Shoshonitic rocks are syenitic to monzonitic in composition that can be divided into the granular and porphyroid groups. Methods: Studying biotites generally occurs as primary and secondary types. The primary biotites are large poikilitic phenocrysts associated with Fe-Ti oxides, giving the rocks a spotted texture. In addition, secondary biotites show varying size, color, and shape. All of the Lar analyzed biotites are Mg-and Ti-rich and F- and Cl-poor. Analyses of the Lar biotites suggested that crystallization took place at an average temperature of 731°C and 640°C for primary and secondary samples, respectively. Results: Estimation of the oxygen fugacity, based on chemical composition and Fe3+ content of biotite, shows that the oxygen fugacity was limited in fayalite-magnetite quartz to middle of HM buffers in quality and was about 10−12 to 10−14 bar in quantity for primary and secondary type, respectively. Halogen fugacity ratios in biotite show that the Lar porphyroid rocks (ore-bearing) are affected mainly by meteoric water than granular type (barren). Calculated halogen fugacity values for biotite in the Lar Cu-Mo prospect are consistent with many other porphyry copper-forming systems. Conclusion: The Lar Cu-Mo prospect was formed by the hydrothermal activity related to the syenitic to monzonitic porphyroid igneous rocks with shoshonitic nature which introduces the Lar igneous complex volcanic sequence. The hydrothermal alterations are limited and occurred as silicic, potassic, phyllic, propylitic, and argillic. Hypogene sulfide minerals mainly occur as disseminated and sulfidic and silicic veins and veinlets consisting of chalcopyrite, bornite, molybdenite, and minor pyrite. Biotite as main ferromagnesian mineral of host rocks occurs as primary in less altered rocks and secondary in the alteration areas.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1173
      Issue No: Vol. 11, No. 03 (2017)
       
  • Study of commercial product range and rules of use of medical thermometers

    • Authors: I. I. Baranova
      Abstract: Aim: The aim of this study is to analyze the assortment, purpose, principles of work, and commodity characteristics of medical thermometers, which are present in the modern pharmaceutical market of Ukraine. Materials and Methods: Logical and analytical methods were used for the analysis of the data of specialized literature and the regulatory legal framework, as well as the data of the state registration, which are presented in the state register of medical equipment and medical products in the group: Medical thermometers. Results and Discussion: The commercial product range of medical thermometers, their varieties and structural features, and principles of work is analyzed. The data from our carried out research work indicate the relevance of further study for this assortment segment of medical products to systematize medical thermometers and analyze in detail the consumer characteristics of them. Conclusions: Based on the analysis of the Ukrainian market, it was established that the dominant positions in the range of medical thermometers were occupied by foreign manufacturers from China, Japan, USA, Great Britain, and Germany. Ukraine needed to improve its own research in the field of development of new types of this product, as well as to take over the experience of foreign manufacturers regarding the variety of additional functions for thermometers, their range, and methods of their manufacture.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1174
      Issue No: Vol. 11, No. 03 (2017)
       
  • Antimicrobial activity of Heterodermia incana (Stirt.) D.D. Awasthi

    • Authors: H. L. Raghavendra
      Abstract: Objectives: Lichens represent one of the most successful symbiotic interactions and are formed from a photobiont and a mycobiont. The foliose lichen genus Heterodermia is one of the cosmopolitan lichen genera. The present study was conducted to investigate antibacterial and antifungal activity of Heterodermia incana (Stirt.) D.D. Awasthi, a foliose macrolichen belonging to the family Physciaceae. Materials and Methods: Extraction of dried and powdered lichen was carried out by maceration process. Antibacterial activity of the extract was evaluated against 2 Gram-positive and 2 Gram-negative bacteria by agar well diffusion assay. Antifungal activity of extract was determined against 3 seedborne fungi by poisoned food technique. Results: Extract was effective in inhibiting the growth of all test bacteria in a concentration dependent manner with marked activity against Gram-positive bacteria. Bacillus cereus (zone of inhibition 2.26 ± 0.05 cm) and Pseudomonas aeruginosa (zone of inhibition 1.76 ± 0.05 cm) were inhibited to higher extent among Gram-positive and Gram-negative bacteria, respectively, at 10 mg/ml extract concentration. The extract was effective in inhibiting the mycelial growth of test fungi in a concentration dependent manner. Among three fungi, the susceptibility to extract was in the order: Fusarium sp. > Curvularia sp. > Alternaria sp. At extract concentration 1 mg/ml, >60% inhibition of all test fungi was observed. Conclusion: The lichen H. incana is a promising resource of antimicrobial agents. The observed bioactivities could be attributed to the presence of secondary metabolites such as atranorin and zeorin present in the extract. In suitable form, the lichen can be used as anti-infective agent and in the management of seedborne fungal diseases.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1175
      Issue No: Vol. 11, No. 03 (2017)
       
  • Phytochemical and antioxidant evaluation of Ipomoea reniformis

    • Authors: Ajay Raghuvanshi
      Abstract: Objective: Ipomoea reniformis was studied for its traditionally claimed activity, and still, it is unexplored. The plant can be further explored for the study of traditionally claimed unexplored activities, as well as isolation and identification of active constituents may lead to new findings. The objective of our study is to investigate antioxidant activity of the extracts of I. reniformis using in vitro models. The measured quantity of extract of I. reniformis was evaluated for its antioxidant activity as compared with standard by different models. The present investigation may be concluded that the plant I. reniformis is endowed with significantly antioxidant activity due to the presence of phenolics and flavonoids, thereby justifying its use in the indigenous system of medicine. Materials and Methods: I. reniformis was collected, dried, and extracted with different solvents, and finally, five extracts were studied for their total phenolics and flavonoids content followed by determination of antioxidant activity by 1, 1-diphenyl-2-picrylhydrazyl, superoxide radical scavenging, and α-amylase inhibitory activity. Results: The obtained results showed that ethanolic extract contains a higher concentration of phenolics and flavonoids and showed highest antioxidant activity among all the samples. Conclusion: The plant showed the antioxidant activity, and we believe that antioxidant activity of I. reniformis was due to synergistic effect of phytochemicals present in it. Further evidencing the need to conduct studies that can identify the active components responsible for the activity.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1176
      Issue No: Vol. 11, No. 03 (2017)
       
  • Protective properties of dietary inclusion of Ocimum sanctum on
           cisplatin-induced nephrotoxicity in rats

    • Authors: Ashish Manigauha
      Abstract: Background: Nephrotoxicity is a frequent severe side effect of cisplatin chemotherapy, limiting its clinical use despite being one of the most potent chemotherapy drugs. In this study, we investigated the nephroprotective potential of dietary containing Ocimum sanctum against cisplatin-induced nephrotoxicity in rats. Materials and Methods: Adult male rats were randomly divided into four groups with six animals in each group. Groups 1 and 2 were fed basal diet (50% skimmed milk, 36% corn starch, 10% groundnut oil, and 4% mineral and vitamin premix) for 6 weeks. Groups 3 and 4 were fed basal diet supplemented with 2% and 4% O. sanctum leaves, respectively, for 6 weeks. Groups 2-4 received a single intraperitoneal dose of cisplatin (7.5 mg/kg BW) after the 5th week of the experiment. Histopathological study of kidney was performed using light microscopy. Results: The blood urea, creatinine, uric acid, total protein, blood urea nitrogen (BUN), urine volume, and urine pH were analyzed. The administration of basal diet supplemented with 2% and 4% O. sanctum to rats significantly reduced the creatinine, urea, uric acid, urine pH, BUN, and total protein compared to cisplatin control group, while a significant increase in urine output was observed. Pretreatment with a basal diet supplemented with 2% and 4% O. sanctum were significantly prevented histopathological changes in kidney toward normal. Conclusion: These results suggest that dietary inclusion of O. sanctum could protect against cisplatin-induced nephrotoxicity.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1177
      Issue No: Vol. 11, No. 03 (2017)
       
  • Diaplant: Manufacturing technology and rationalization of costs of acute
           intestinal infection pharmacotherapy

    • Authors: T. Ivko
      Abstract: Aim: To the development of the technological scheme of a new drug Diaplant, and rationalization of the costs of the acute intestinal infection (AII) pharmacotherapy. Materials and Methods: Development of the technological scheme of the new drug in tablets called Diaplant; analysis of the Ukraine pharmaceutical market of the analogs of Diaplant; pharmacoeconomic advantages of Diaplant compared with its analogs. Results and Discussion: In the pharmaceutical market of Ukraine, there are groups А07 antidiarrheals, intestinal anti-inflammatory/anti-infective agents according to Anatomical Therapeutic Chemical (ATC)-classification. ATC/defined daily dose (DDD)-analysis showed that the cost for DDD of Diaplant was 9.60 UAH. The total cost of the average recommended daily doses of separate drugs (nifuroxazide and plantaglucidum) ranged from 14 to 27.42 UA. The use of the drug Diaplant for the treatment 1000 patients requires 9600 UAH daily and 288000 UAH monthly. The use of other drugs with nifuroxazide and plantaglucidum requires from 14000 to 27420 UAH daily and from 420,000 to 822,600 UAH monthly. Savings of financial resources can be from 4400 to 17,820 UAH/day and – from 132,000 to 534,600 UAH/month for 1000 patients receiving Diaplant. It has been found that the Diaplant can provide the treatment from 1460 to 2860 patients instead of only 1000 patients receiving its analogs at the pharmaceutical market of Ukraine. Conclusion: The technological scheme of production of the drug in capsules Diaplant that contains nifuroxazide and plantaglucidum were developed for pharmacotherapy of AIIs. The use of Diaplant in clinical practice allows reducing the cost of pharmacotherapy from 46% to 286%.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1178
      Issue No: Vol. 11, No. 03 (2017)
       
  • Functional complementation of pop2-3 T-DNA insertion mutant of Arabidopsis
           thaliana by overexpression of gamma-aminobutyric acid transaminase gene to
           reveals its role in complex pattern of leaf senescence

    • Authors: Mohammad Israil Ansari
      Abstract: Aim: Gamma-aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the mammalian central nervous system, and its important role is reducing the neuronal excitability throughout the nervous system. The GABA transaminase (GABA-T) enzyme catalyzes the transamination of GABA to form succinic semialdehyde using pyruvate as amino acid acceptor in GABA shunt pathway. The Arabidopsis thaliana GABA-T gene (pollen-pistil incompatibility 2 [POP2]; At3g22200) belongs to Class III pyridoxal-phosphate-dependent aminotransferase family. The full-length cDNA of the gene encodes a protein of 513 amino acids residues and located at chromosome 3. It could be demonstrated that the GABA-T is involved in the regulation of leaf senescence in A. thaliana. Materials and Methods: To ensure the role of GABA-T gene in leaf senescence, we have performed functional complementation using transformation of pPZP200GB-GABA-T construct into pop2-3 T-DNA insertion mutant (GABA-T knockout mutant) of A. thaliana (GABA-T complement plant) that the mutant plant reverts back to wild-type plant. We have measured and compared the physiological characteristics associated with senescence (chlorophyll content, ion leakage and lipid peroxidation) and quantified the GABA shunt components (GABA content, GABA-T, and glutamate decarboxylase activity) of the wild-type, pop2-3 mutant, and GABA-T complement plant of A. thaliana. Results: The result showed the low chlorophyll content, increased ion leakage, and higher level of lipid peroxidation in pop2-3 mutant than wild-type plant after 30 days in normal growth condition. GABA-T pop2-3 mutants act as signals that mediate early leaf senescence. GABA-T complement plant shared similar characteristics of senescence parameters with wild-type plants. Conclusion: These data concluded that GABA-T is involved in the regulation of leaf senescence in A. thaliana.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1179
      Issue No: Vol. 11, No. 03 (2017)
       
  • Protective effect of dietary inclusion of Aegle marmelos fruit on
           gentamicin-induced hepatotoxicity in rats

    • Authors: Ram Kumar Sahu
      Abstract: Background: The present study was undertaken to investigate the modulatory efficacy of dietary inclusion of Aegle marmelos fruit against gentamicin-induced liver injury in Wistar albino rats. Methods: The animals were divided into five groups and each containing six animals. Group I and Group II received basal diets and basal diets with 4% w/w A. marmelos, respectively. Group III, Group IV, and Group V fed basal diets, basal diets containing 2% w/w, and 4% w/w A. marmelos, respectively for 27 days before gentamicin administration. The intraperitoneal administration of gentamicin (100 mg/kg body weight) for 3 days leads to disturbed the hepato-specific serum markers. Liver functions were measured by the valuation of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), serum acid phosphatase (ACP), and total bilirubin. The oxidative stress parameter and antioxidant markers were also evaluated. Moreover, histopathological evaluation was performed to assess liver case regarding inflammatory infiltration or necrosis. Results: Gentamicin produced significant changes in liver marker enzymes (increase in SGOT, SGPT, ALP, ACP, and bilirubin level) and histological (damage to hepatocytes). Gentamicin also leads to significant changes in the level of lipid peroxidation, superoxide dismutase, glutathione, and catalase in liver homogenate. The administration of basal diet supplemented with 2% and 4% A. marmelos to rats significantly reversed the above changes compared to the control group as observed in the gentamicin-treated rats. Conclusions: The results propose that dietary inclusion of A. marmelos fruits possesses promising hepatoprotective effects and could protect the liver against gentamicin-induced hepatic injury.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1180
      Issue No: Vol. 11, No. 03 (2017)
       
  • Bioaccumulation of chromium and nickel by fungal isolates from tannery
           effluent collection site from Kanpur, Uttar Pradesh, India

    • Authors: Monowar Alam Khalid
      Abstract: Aim: The aim of study was to analyze the physicochemical properties of tannery effluent and to isolate the promising fungi from heavy metals contaminated effluent to assess their metals accumulating abilities against chromium and nickel. Materials and Methods: The physiochemical parameters of tannery wastewater were analyzed. Aspergillus niger and Penicillium species were isolated and identified on the basis of their morphological and microscopic studies. The 6 heavy metals (Ni, Cu, Cr, Pb, Hg, and As) were analyzed through atomic absorption spectrometer from collected sample. Isolated fungal strains were assessed for their tolerance level against chromium and nickel heavy metals. Minimum inhibitory concentration was determined by well diffusion plate assays in Sabouraud dextrose agar medium. Bioaccumulation of chromium and nickel was determined on the basis of left metal ion concentration in aqueous medium. Results: Total dissolved solids, total suspended solids, and chloride were found to be 21300 mg/l, 1250 mg/l, and 740 mg/l, respectively. The pH and temperature of the wastewater were recorded to be 8.3 and 31°C, respectively. Dissolved oxygen (DO), biochemical oxygen demand, and chemical oxygen demand was found to be 2.72 mg/l, 3000 mg/l, and 3584 mg/l, respectively. The heavy metals such as nickel, chromium, copper, lead, mercury, and arsenic were found to be 0.280 mg/l, 0.478 mg/l, 0.006 mg/l, 0.0001 mg/l, 6.899 μg/l, and 0.790 μg/l, respectively. Aspergillus niger and Penicillium species were isolated and identified from the tannery effluent. A. niger tolerated 600 mg/l Cr and 100 mg/l Ni. Penicillium species tolerated up to 800 mg/l Cr and 400 mg/l Ni. Accumulation of A. niger at 25 mg/l aqueous medium of chromium was found to be 50.12%, at 50 mg/l 42.76%, at 100 mg/l 27.18% while Penicillium accumulation at 25 mg/l was 27.08%, at 50 mg/l 35.68%, at 100 mg/l 27.62%. In case of nickel accumulation of A. niger at 25 mg/l aqueous medium of nickel 66.64%, at 50 mg/l 37.70%, at 100 mg/l 34.47% while Penicillium accumulation at 25 mg/l 49.92%, at 50 mg/l 44.76%, at 100 mg/l 18.02%. Conclusion: The results of the study indicated the potential of these fungi in removal of heavy metals from industrial effluents containing higher concentration of heavy metals, namely, chromium and nickel. The further studies warranted to identify different fungi species capable of bioaccumulation of toxic heavy metals.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1181
      Issue No: Vol. 11, No. 03 (2017)
       
  • Agrogeosystems of Krasnoyarsk Krai: Natural resource potential,
           environmental stability, optimization of functioning

    • Authors: Alexander A. Shpedt
      Abstract: Aim: The article presents the estimation of natural resource potential (NRP) of agrogeosystems of taiga-forest and forest-steppe zones, environmental stability and anthropogenic transformation to further optimization of their functioning. Methods: Agrogeosystems of the typical forest-steppe possess the greatest NRP; the ones of the south taigaforest zone have middle potential. Agrogeosystems of the open forest-steppe adjoining to a large megalopolis possesses low potential. The intensification of farming determines the degree of anthropogenic transformation of the territory. Agrogeosystems of the open and typical forest-steppe are environmentally unstable, but those of the south taiga-forest zone are stable, which is determined by a small fraction of plowland in the total structure of land resources and extensive territory of subtaiga, occupied by forests of natural origin and idle lands. Result and Discussion: The integral estimation of the whole set of climatic, soil, hydrological, geomorphological, and geological components allows to state the agrogeosystem of the typical foreststeppe has the largest NRP, the one of the taiga-forest zones possesses the middle NRP, and the agrogeosystem of the open forest-steppe, located near a large megalopolis, has the lower NRP. Conclusion: Long-term application of organic fertilizers on gray forest soils of subtaiga increases the humus content and base saturation reduces the acidity of the soil, provides a positive balance of elements of a mineral delivery, which causes an increased reproduction of fertility and stabilizes a high level of production processes in the agrolandscape.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1182
      Issue No: Vol. 11, No. 03 (2017)
       
  • Ecological aspects of multi-locus variability of DNA markers in animals

    • Authors: Eduard A. Snegin
      Abstract: Aim: The work presents the algorithm for calculating the potential number of genetic combinations with an increase in the animal population to infinity. Methods: Calculations were carried out using the methods of bias corrected form for the Chao 1 and the 1st order jackknife, based on the multi-locus variability of DNA markers (RAPD and ISSR) in two specially protected species of Lucanus cervus (stag-beetle) and Helicopsis striata (steppe snail). Results: According to the obtained data, the groups, inhabiting relict biocenoses, are the most prominent among the populations of two species. There is the largest number of multi-locus genotypes, most of which are unique.The most monomorphic are the populations, inhabiting technogenic territories, because strongly isolated and small groups of animals are formed here very often. Their drift of genes leads to a decrease in allelic diversity. Conclusion: In addition, it has been established, that dapper animals (insects) are better adapted for existence in anthropogenic environment, than sedentary species (snails).
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1183
      Issue No: Vol. 11, No. 03 (2017)
       
  • Productivity and health markers for large cattle

    • Authors: I. M. Donnik
      Abstract: Aim: For the first time, the Ural region reported positive results on the study of syncytial test diagnostic value at an early detection of the cattle leukemia virus carriers. Method: Study includes an intraperitoneal infection of laboratory animals (small ruminants) by the leukocyte suspension containing viral material. To perform the comparative diagnostic studies, they developed a group of animals kept in isolation, weekly studied by serological (infectious disease requisition [IDR] and enzyme-linked immunosorbent assay [ELISA]), molecular genetic (polymerase chain reaction [PCR]), cultural (ST) diagnostic research starting from the 6th day after infection. Results: Performed laboratory studies confirmed the diagnostic value of direct method identification concerning the causative agent of cattle leukemia. Thus in the earliest period (13 days) after the artificial infection of laboratory animals, they revealed a positive reaction in the syncytial method of research, which is confirmed by the controls. Positive PCR was revealed in 21 days, during the third study, and IDR and ELISA were revealed only on the 37th day (week 5). Conclusion: The developed early diagnosis of leukemia will improve the efficiency of agricultural enterprise recovery from the infection as the isolation of infected animals during the earliest period is one of the priority tasks during the implementation of health programs.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1184
      Issue No: Vol. 11, No. 03 (2017)
       
  • The state of gray forest soils, conditioned by microclimatic variability,
           in the south of the forest-steppe of the Central Russian Upland

    • Authors: Lidia G. Smirnova
      Abstract: Aim: The present study aimed to address the issues, relating to indicators of the soils state in conditions of climatic dynamics for the forest type phytocenoses of the south of the forest-steppe of the Central Russian Upland. Materials and Methods: The terrain of the studied area is a river valley of the Seversky Donets. A field study of soils and laboratory soil diagnostics were the basis of the research methodology. Soil survey data were analyzed for the period from 2011 to 2014. Chemical analysis of soil samples was carried out at the Federal State Funded Research Institution “Belgorod Agricultural Research Institute.” The geoinformational system ArcGis (in ArcMap software) with satellite mapping was used to prepare the map of the study area on the right bank of the river Seversky Donets 9. Results and Discussion: In the south of the forest-steppe of the Central Russian Upland, on the right bank of the river Seversky Donets, a certain regularity in the spatial arrangement of the subtypes of gray forest soils is observed: Gray forest soils are formed on the steep slopes (from 5° to 18°) of the north-eastern, north-north-eastern, and eastern exposures, in forest phytocenoses; and dark gray forest soils are formed on the upland and upper slope territories (from 0° to 5°). When calculating microclimatic parameters, it was established that the amount of multiyear temperatures over 10°C on slopes decreases with increasing their steepness. Humidity factor increases with the steepness of the slope in the northeast and north-north-east directions; the reverse pattern is noted for the eastern slope. Conclusion: Dark gray forest soils have a thickness of humus horizon from 42 to 52 cm. They have a higher level of fertility that is expressed in a low value of hydrolytic acidity, in a higher content of calcium and magnesium in the absorbing complex, compared to gray forest soils under the conditions of given forest phytocenosis. In both soil subtypes, a very low content of liable phosphorus, mobile potassium, and nitrate nitrogen was observed.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1185
      Issue No: Vol. 11, No. 03 (2017)
       
  • The analysis of the flora invasive component in the southwest of the
           Central Russian Upland (Russia)

    • Authors: Ludmila A. Tokhtar
      Abstract: Aim: Analytical characteristics of the flora invasive component in the southwest of the Central Russian Upland are presented in this work. Methods: The intensification of allogenic plants relocation into the region is confirmed by the findings of 13 new adventitious species: Amaranthus cruentus, Campanula × spryginii, Centaurea montana, Commelina communis, Grindelia squarrosa, Jurinea charcoviensis, Lupinus polyphyllus, Nicotiana rustica, Onobrychis tanaitica, Panicum dichotomiflorum, Physalis philadelphica, Ptelea trifoliata, and Thladiantha dubia.Results: It was defined, that Asteraceae (21.2%) and Poaceae (9.3%) took the leading position in the hierarchy of the flora invasive component. Eumosophytes (48.8%), xeromesophytes (31.6%), and mesocerphophytes (13.1%) prevailed with regard to moisture conditions.According to the life forms of Raunkier, invasive species of the region were represented mainly by terophytes (35.6%), and phanerophytes (31.6%). Conclusion: The greatest number of invasive species was found within the boundaries of transport highways, valleys of small rivers, floodplain meadows, and the fewest number - in the areas of cereal-meadow steppes and in the forest phytocenoses.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1186
      Issue No: Vol. 11, No. 03 (2017)
       
  • The research of clonal micropropagation efficiency of Schisandra chinensis
           under the influence of low-intensity coherent radiation

    • Authors: Ludmila A. Tokhtar
      Abstract: Aim: The present study reveals the results of an investigation on the effect of low-intensity coherent radiation (LCR) on the efficacy of clonal micropropagation of medicinal plant - Schisandra chinensis (Turcz.) Baill. Experimental: Cultivation of plants in vitro, a mineral base of the nutrient medium was used with the addition of 30 g/l sucrose, 100 mg/l mesoinositol, 250 mg/l casein hydrolyzate, 8 g/l agar and vitamin complex of Murashige-Skoog. During microcuttings, rooting macrosalts and sucrose concentration reduced to half; indole butyric acid at a concentration kept at 1.0 mg/l. Sterile microcuttings were treated with radiation from a helium-neon laser, GN-40 (wavelength 632.8 nm, power density 2 W/m2), and semiconductor HLDPM12-655-10HJ (wavelength 655 nm, power density 2 W/m2) at various exposures (30, 60, 120, 240, 480, 960 s) on 3-4 days after their planting into the propagation medium or rooting directly in the culture bottles. Result and Discussion: It has been established, that the use of LCR at the stage of rhizogenesis significantly stimulates the process of microcuttings rooting in vitro and promotes an increase in the number and length of roots and growth of shoots. The selection of in vitro conditions and irradiation treatment of the obtained S. chinensis microshoots by helium-neon laser, during the propagation stage, allow to increase the number of viable explants of this culture from 60.0% ± 6.3% in the control sample, up to 90.9% ± 3.5% in the test sample with 120 s exposure of irradiation. With this exposure, the share of microshoots with a net reproduction more than 1, increased from 44.4% to 75.5%. Conclusion: Due to low rates of reproduction and rooting, a slow growth rate of shoots and roots, latent bacterial infections, significantly reduce the method clonal micropropagation for S. chinensis. Laser coherent radiation stimulates the process of microcuttings rooting in vitro at the stage of rhysogenesis of S. chinensis (Turcz.) Baill leads to increase in number and length of root and shoot system.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1187
      Issue No: Vol. 11, No. 03 (2017)
       
  • Development of novel docetaxel-loaded gelatin nanoparticles for
           intravenous application: Hemolytic activity, hematological study, and
           biodistribution profile or in vivo cancer study

    • Authors: Alok Pal Jain
      Abstract: Aim: The aim of this study to evaluates the physiochemical properties, drug loading, in vitro release, and anticancer study. Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death. Docetaxel is used to treat primary breast cancer (cancer that started in the breast and has not spread to other parts of the body) in combination with other specific chemotherapy drugs. Docetaxel is also used alone or with other drugs to treat cancer that has spread to areas around the breast such as the lymph nodes above or below the collarbone (known as regional or locally advanced recurrence), or to other parts of the body (secondary breast cancer). Materials and Methods: Docetaxel-loaded gelatin nanoparticles using ultraviolet-visible spectroscopy, X-ray diffraction, particle size and size distribution, scanning electron microscopy, drug entrapment efficiency, differential scanning calorimetry, and energy dispersive X-ray were characterized. Results: Solubility, crystallinity, and the crystal properties of an active pharmaceutical ingredient play a critical role in the value chain of pharmaceutical development, manufacturing, and formulation. The rate of drug release for formulation stored at 45 ± 1°C was increased as compared with the fresh formulation; it might be due to the formation of more pores in the nanoparticles due to evaporation of residual amount of solvent. The tissue distribution studies were performed with docetaxel-loaded gelatin nanoparticles after intravenous (IV) injection in Ehrlich ascites tumor-bearing mice. The tissue distribution studies showed a higher concentration of docetaxel- in the tumor as compared with gelatin nanoparticles. The in vivo tumor inhibition study was also performed after IV injection of docetaxel-loaded gelatin nanoparticles up to 15 days. The docetaxel-loaded gelatin nanoparticles reduced tumor volume significantly as compared with plain docetaxel. Our results revealed that docetaxel-loaded gelatin nanoparticles may perhaps maintain the antioxidant levels and reduce the tumor markers thereby exerting chemopreventive potential. Conclusion: These findings support the use of docetaxel-loaded gelatin nanoparticles in target-specific therapy for cancer treatment.
      PubDate: 2017-10-16
      DOI: 10.22377/ijgp.v11i03.1188
      Issue No: Vol. 11, No. 03 (2017)
       
 
 
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