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Publisher: Medknow Publishers   (Total: 354 journals)

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Showing 1 - 200 of 354 Journals sorted alphabetically
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advances in Human Biology     Open Access   (Followers: 2)
African J. for Infertility and Assisted Conception     Open Access  
African J. of Business Ethics     Open Access   (Followers: 6)
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.269, h-index: 10)
African J. of Trauma     Open Access  
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 6)
Anesthesia : Essays and Researches     Open Access   (Followers: 8)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.331, h-index: 15)
Annals of Bioanthropology     Open Access   (Followers: 4)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.408, h-index: 15)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.308, h-index: 14)
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 7, SJR: 0.441, h-index: 10)
Annals of Saudi Medicine     Open Access   (SJR: 0.24, h-index: 29)
Annals of Thoracic Medicine     Open Access   (Followers: 4, SJR: 0.388, h-index: 19)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 15, SJR: 0.148, h-index: 5)
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Intl. Surgery     Open Access   (Followers: 10)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Pharmacy Practice     Open Access   (Followers: 6)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 3)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.879, h-index: 49)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 2, SJR: 0.362, h-index: 10)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Cancer Translational Medicine     Open Access   (Followers: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 1)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 12, SJR: 0.82, h-index: 12)
Contemporary Clinical Dentistry     Open Access   (Followers: 4)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.339, h-index: 19)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.131, h-index: 4)
Dental Research J.     Open Access   (Followers: 11)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 5, SJR: 0.205, h-index: 22)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.121, h-index: 3)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Orthopaedic J.     Open Access   (Followers: 1)
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.473, h-index: 8)
Environmental Disease     Open Access   (Followers: 2)
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.496, h-index: 11)
European J. of General Dentistry     Open Access   (Followers: 1)
European J. of Prosthodontics     Open Access   (Followers: 3)
European J. of Psychology and Educational Studies     Open Access   (Followers: 9)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.107, h-index: 5)
Genome Integrity     Open Access   (Followers: 4, SJR: 1.227, h-index: 12)
Global J. of Transfusion Medicine     Open Access   (Followers: 2)
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
IJS Short Reports     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 8, SJR: 0.302, h-index: 13)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (SJR: 0.318, h-index: 26)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.618, h-index: 16)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.307, h-index: 16)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.243, h-index: 24)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.448, h-index: 16)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 3, SJR: 0.563, h-index: 29)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.292, h-index: 9)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.53, h-index: 34)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.716, h-index: 60)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.207, h-index: 31)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.233, h-index: 12)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.213, h-index: 5)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 4, SJR: 0.203, h-index: 13)
Indian J. of Ophthalmology     Open Access   (Followers: 5, SJR: 0.536, h-index: 34)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 10, SJR: 0.393, h-index: 15)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.218, h-index: 5)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.35, h-index: 12)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 1, SJR: 0.285, h-index: 22)
Indian J. of Pharmacology     Open Access   (SJR: 0.347, h-index: 44)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.303, h-index: 13)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.496, h-index: 15)
Indian J. of Psychological Medicine     Open Access   (Followers: 1, SJR: 0.344, h-index: 9)
Indian J. of Public Health     Open Access   (Followers: 1, SJR: 0.444, h-index: 17)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4, SJR: 0.253, h-index: 14)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.169, h-index: 7)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.313, h-index: 9)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.366, h-index: 16)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 4, SJR: 0.229, h-index: 13)
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 7)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.239, h-index: 4)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.523, h-index: 15)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 7, SJR: 0.611, h-index: 9)
Intl. J. of Trichology     Open Access   (SJR: 0.37, h-index: 10)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 5)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 3)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 4, SJR: 0.427, h-index: 15)
J. of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 8, SJR: 0.416, h-index: 14)
J. of Applied Hematology     Open Access  
J. of Association of Chest Physicians     Open Access   (Followers: 2)
J. of Basic and Clinical Reproductive Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Therapeutics     Open Access   (Followers: 4, SJR: 0.359, h-index: 21)
J. of Carcinogenesis     Open Access   (Followers: 1, SJR: 1.152, h-index: 26)
J. of Cardiothoracic Trauma     Open Access  
J. of Cardiovascular Disease Research     Open Access   (Followers: 3, SJR: 0.351, h-index: 13)
J. of Cardiovascular Echography     Open Access   (SJR: 0.134, h-index: 2)
J. of Cleft Lip Palate and Craniofacial Anomalies     Open Access   (Followers: 2)
J. of Clinical and Preventive Cardiology     Open Access   (Followers: 1)
J. of Clinical Imaging Science     Open Access   (Followers: 1, SJR: 0.277, h-index: 8)
J. of Clinical Neonatology     Open Access   (Followers: 1)
J. of Clinical Ophthalmology and Research     Open Access   (Followers: 2)
J. of Clinical Sciences     Open Access  
J. of Conservative Dentistry     Open Access   (Followers: 4, SJR: 0.532, h-index: 10)
J. of Craniovertebral Junction and Spine     Open Access   (Followers: 4, SJR: 0.199, h-index: 9)
J. of Current Medical Research and Practice     Open Access  
J. of Current Research in Scientific Medicine     Open Access  
J. of Cutaneous and Aesthetic Surgery     Open Access   (Followers: 1)
J. of Cytology     Open Access   (Followers: 1, SJR: 0.274, h-index: 9)
J. of Dental and Allied Sciences     Open Access   (Followers: 2)
J. of Dental Implants     Open Access   (Followers: 7)
J. of Dental Lasers     Open Access   (Followers: 2)
J. of Dental Research and Review     Open Access   (Followers: 1)
J. of Digestive Endoscopy     Open Access   (Followers: 3)
J. of Dr. NTR University of Health Sciences     Open Access  
J. of Earth, Environment and Health Sciences     Open Access   (Followers: 1)
J. of Education and Ethics in Dentistry     Open Access   (Followers: 5)
J. of Education and Health Promotion     Open Access   (Followers: 5)
J. of Emergencies, Trauma and Shock     Open Access   (Followers: 9, SJR: 0.353, h-index: 14)
J. of Engineering and Technology     Open Access   (Followers: 6)
J. of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
J. of Family and Community Medicine     Open Access   (Followers: 2)
J. of Family Medicine and Primary Care     Open Access   (Followers: 11)

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Journal Cover International Journal of Green Pharmacy
  [SJR: 0.229]   [H-I: 13]   [4 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 0973-8258 - ISSN (Online) 1998-4103
   Published by Medknow Publishers Homepage  [354 journals]
  • Remedial merits of Piper longum Linn with astonishing antidiabetic
           potential

    • Authors: K. R. C. Reddy
      Abstract: Over the past three decades, the number of people with diabetes mellitus (DM) has doubled globally, making it one of the most important public health challenges to all nations. This has been stimulating the development of novel and potentially more effective therapeutic approaches to treat the disease. Even after the availability of a massive amount of hypoglycemic drugs in conventional system, herbals are gaining much attention because of its spectacular therapeutic potential and also help to sustain the healthy condition of the body. In this review article, a highly valuable drug Pippali (Piper longum) has been evaluated on the basis of its pharmacognostical, pharmacological, and therapeutical background. The plant possesses significant antidiabetic activity. The systemic dysfunction associated with DM can also be cured by Pippali. Plant through exhibiting synergistic action gives a valuable response in hepatic, digestive, cardiac, and respiratory disorders. The purpose of this review is to enlighten all the remedial aspects of P. longum with a special focus on its antidiabetic potential.
      PubDate: 2018-01-04
      Issue No: Vol. 10, No. 04 (2018)
       
  • Phytochemistry, traditional uses, and pharmacological activities of Azima
           tetracantha Lam. (Salvadoraceae) - An updated review

    • Authors: Dr. H. L. Raghavendra
      Abstract: Plants form an integral part of daily life of human beings. The term ethnobotany refers to relationships and interactions between people and plants. Worldwide, plants are being used as sources of food, medicine, dyes, and timber. Traditional medicinal practitioners and indigenous systems of medicine (such as Ayurveda, Siddha and Unani) make use of several plant species to treat a range of ailments of humans and livestock. The therapeutic potential of plants lies in the presence of secondary metabolites such as alkaloids, terpenes, and polyphenolic compounds. Azima tetracantha Lam., belonging to the family Salvadoraceae, is a small, armed shrub with quadrangular branches. The present review is a compilation of available data on the ethnomedicinal uses, phytochemistry, and pharmacological activities of A. tetracantha. Phytochemical investigations on the plant revealed the presence of chemicals such friedelin, euphanol, gallic acid, genstisic acid, cinnamate, ferulic acid, azimine, azcarpine, and carpaine. An extensive literature survey was carried out to compile data on traditional uses, phytochemicals, and the pharmacological activities shown by A. tetracantha. It is evident from the literatures that the plant is versatile with respect to its traditional uses as a remedy for various illnesses and disorders in humans and animals. The plant is used for treatment of asthma, cold, cough, rheumatism, diabetes, dysentery, fever, toothache, dog bite, snake bite, and liver diseases. It is experimentally shown that the plant exhibits pharmacological activities such as antimicrobial, antioxidant, anti-inflammatory, cytotoxic, antivenom, hepatoprotective, antiepileptic, diuretic, antiulcer, antiasthmatic, antidiarrheal, analgesic, nephroprotective, antipyretic, and insecticidal activity. The nanoparticles synthesized from A. tetracantha have shown antimicrobial, antioxidant, and insecticidal properties. A pentacyclic triterpenoid friedelin isolated from the plant is shown to exhibit many bioactivities such as antimicrobial, hypolipidemic, antidiarrheal, anti-inflammatory, antipyretic, insecticidal, gastroprotective and antiradical activity. The therapeutic potential and pharmacological properties of A. tetracantha could be ascribed to the presence of a wide array of phytochemicals in it. The pharmacological activities of the plant reported justify the traditional use of A. tetracantha in treating several diseases or disorders.
      PubDate: 2018-01-04
      Issue No: Vol. 10, No. 04 (2018)
       
  • Anticancer potential of nutraceutical formulation through antioxidant,
           anti-inflammatory, and antiproliferative mechanisms in
           N-methyl-N-nitrosourea-induced mammary cancer

    • Authors: Gummalla Pitchaiah
      Abstract: Background: Previous investigation has shown the promising anticancer potential of nutraceutical formulations prepared using fine powders of amla, apple, garlic, onion, papaya, turmeric, wheatgrass, and cow urine distillate in N-methyl-N-nitrosourea (MNU)-induced mammary cancer. Combination of nutraceuticals is known to act by multiple mechanisms in the prevention of cancer. Aim: An evaluation was performed to study the possible mechanisms involved in the anticancer potential of self-fortified nutraceutical formulation (SFNF) in MNU-induced mammary cancer in Sprague Dawley rats. Materials and Methods: Mammary cancer was induced using MNU in female Sprague Dawley rats. At the end of experimental period, mammary tissues were analyzed for malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), myeloperoxidase (MPO), and tumor necrosis factor-alpha (TNF-α) levels. Similarly, serum samples were analyzed for Estradiol (E2) and insulin-like growth factor 1 (IGF-1) levels. Immunohistochemical analysis of Ki-67 antigen was performed in mammary tissues. Results: Findings from this study showed that the tissue MDA levels were decreased; SOD and CAT levels were increased in SFNF supplemented rats. SFNF supplemented rats also showed decrease in MPO and TNF-α level compared to MNU control rats. SFNF supplemented rats showed significant reduction in serum E2 (P < 0.01) and IGF-1 (P < 0.001) levels. Significant reduction in Ki-67 (P < 0.01) immunoreactive cells of tumors of SFNF supplemented rats was also observed. Conclusion: SFNF was effective in the prevention of MNU-induced mammary cancer through antioxidant, anti-inflammatory, and antiproliferative mechanisms in rats.
      PubDate: 2018-01-04
      Issue No: Vol. 10, No. 04 (2018)
       
  • A study of antibacterial, antioxidant and neuroprotective effect of stem
           of Syzygium cumini

    • Authors: Yash Sharma
      Abstract: Aims: The purpose of the present study was to investigate the antibacterial activity, antioxidant activity, and neuroprotective ability of aqueous and alcoholic extracts of the stem of Syzygium cumini. Materials and Methods: Antibacterial activity of the aqueous and alcoholic extracts of stem of S. cumini was observed against two Gram-positive bacteria (Bacillus amyloliquefaciens and Staphylococcus aureus) and two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) by agar well diffusion method. Phytochemical screening was done to reveal the presence of flavonoids in its aqueous, ethanolic, and methanolic extracts of stem of S. cumini. Antioxidant activity was estimated by its enzymatic and non-enzymatic biochemical assay such as superoxide dismutase, catalase, glutathione content, glutathione S-transferase, and malondialdehyde content in the aqueous and methanolic extract. Neuroprotective ability of aqueous and ethanolic extract of stem of S. cumini were observed on Rat pheochromocytoma (PC)-12 cell line, by giving neurotoxic shock to Rat PC-12 cells using 6-hydroxydopamine, Statistical Analysis Used: To estimate the accuracy of the experimental data, each experiment was performed in triplicates, and the result was expressed as mean ± standard deviation of three replications. P < 0.05 was regarded as significant. Results: Antibacterial activity of the aqueous and alcoholic extracts of stem of S. cumini was observed where alcoholic extract showed maximum antibacterial activity against B. amyloliquefaciens and S. aureus. Methanolic extract showed higher level of antioxidant activity as comparative to aqueous extract. Ethanolic extract has shown maximum number of viable cells, i.e., 75% and aqueous extract showed 50% of it. Conclusions: This study suggests that stem can be utilized as a good source of antibacterial, antioxidant, and neuroprotective agent.
      PubDate: 2018-01-04
      Issue No: Vol. 10, No. 04 (2018)
       
  • Assessment of in vitro anthelmintic activity of Heracleum afghanicum
           Kitamura leaves

    • Authors: Dr. Ashish Suttee
      Abstract: Aim and Objective: The present study was carried to determine the anthelmintic activity of Heracleum afghanicum Kitamura (Umbelliferae) collected from the mountainous region of Karmi, Afghanistan. Material and Methods: Different extracts of H. afghanicum Kitamura were screened for anthelmintic activity against Indian earthworm Eisenia foetida. Different concentrations (2–10 mg/ml) of various extracts were tested, and results were expressed in terms of time for paralysis and time for the death of worms. Albendazole (20 mg/ml) was used as the reference standard and normal saline (0.9%) as a control group. Results and Discussion: Dose-dependent activity was observed in the plant extracts. Ethyl acetate extract was found to be exhibit more activity as compared to others. The anthelmintic activity of H. afghanicum Kitamura leaves extract has therefore been demonstrated for the first time. The efficacy of the extracts may be due to the presence of various phytoconstituents. Further studies on isolation of phytoconstituents and their biological activities in vitro and in vivo are to be carried out.
      PubDate: 2018-01-04
      Issue No: Vol. 10, No. 04 (2018)
       
  • Mugdha Rasa an ayurvedic proprietary medicine to treat acne vulgaris

    • Authors: Dr. Vandana Meena
      Abstract: Background: Acne is the disease which agitates the face during the primary phase of life, and if deserted or mistreated might give scar for lifetime, ayurvedic treatment for acne vulgaris has much to offer but lacks in standardization of products. After an investigative search of classics and contemporary science regarding various herbs and minerals, a formulation was selected keeping in the view of attractive hypnotizing behavior of the facial beauty and was named Mugdha Rasa. Objectives: In this study, an attempt was made to standardize Mugdha Rasa on the basis of its classical parameters along with contemporary parameters. Settings and Designs: The formulation contains following ingredients, i.e., Shankha Bhasma, Manjistha (Rubia cordifolia), Sariva (Hemidesmus indicus), Nimba (Azadirachta indica), and Haridra (Curcuma longa) in the ratio 1:4:4:2:2. Initially, Bhavana of Kumari swarasa was given followed by Tulsi swarasa and lastly with Kumari swarasa, to maintain the standard operative procedure. Materials and Methods: Final formulation was analyzed on the parameters of organoleptic characterization and physicochemical analysis. It was further evaluated for microbial limit tests which include tests for total viable count (bacteria and fungi). Results: Mugdha Rasa possessed the reddish brown in color, smooth, and soft on touch with Tikta, Kashaya Rasa and with some non-specific smell. In terms of physicochemical analysis, it was evident that the parameters were within the permissible limits. pH of Mugdha Rasa was 8.88 indicating its compatibility with human skin. The results of total microbial count reported that it is safe for use.
      PubDate: 2018-01-04
      Issue No: Vol. 10, No. 04 (2018)
       
  • Efficacy of screening tests for 11-nor-delta-9-tetrahydrocannabinol
           -carboxylic acid detection in urine

    • Authors: Dr. Yuttana Sudjaroen
      Abstract: Context: Cannabis-abused drivers in Thailand were lower prevalence than alcoholic and amphetamine addicts and police officers were often disregarded. Thus, determination of cannabis metabolites by Thai screening test kits was most important driver inspection. However, missing of interpretation on results of cannabis screening test kits were commonly happening, which according by different of immunoassay application and/or procedure. Urine storage condition was affected to screening results and also may affect to results of confirmatory test by gas chromatography/mass spectrometry (GC/MS). Aims: To compare efficacy of test kits for 11-nor-delta-9-tetrahydrocannabinol-carboxylic acid (THC-COOH) detection in urine and studied on urine storage condition effects on THC-COOH detection using different test kits and GC/MS for screening and confirmatory method, respectively. Materials and Methods: Each standard THC-COOH solution was dissolved in pooled-urine (10–200 ng/ml), which was applied to three commercial test kits. The calculation of sensitivity, specificity, positive predictive value, negative predictive value, and efficiency of test was done. Each pooled-urine containing with THC-COOH (50 ng/ml) was stored in different temperatures and duration prior analysis by test kits and GC/MS. Results and Discussion: Three commercial test kits were gave positive results at 50–200 ng/ml of THC-COOH. No false positive result was appeared. THC-COOH in pooled-urine was detected at 25, 4, and −20°C during 1, 7, and 14 days for all test kits. THC-COOH in storage urine at room temperature (25°C) and longest period (14 days) was able to detect by GC-MS, however, in low concentration. Conclusions: Research finding was providing useful information for forensic laboratory where perform THC-COOH detection for both screening and confirmatory tests
      PubDate: 2018-01-04
      Issue No: Vol. 10, No. 04 (2018)
       
  • Determination of active substances of the “Propolis-Derma”
           pharmaceutical compositions by reverse-phase high-performance liquid
           chromatographic method

    • Authors: O. S. Shpychak
      Abstract: Aim: This study presents the material devoted to working out the methods of identification and quantitative determination of active substances of medicated products “Propolis-Derma” (“Propolis-PNH,” “Propolis-PSC,” and “Propolis-PCD”) with antifungal, antimicrobial, and keratolytic activity, created for the treatment of dermatomycoses, pityriasis versicolor, as well as diseases caused by yeast-like fungi of Candida albicans. Materials and Methods: As a result, the conditions, methods, and opportunity have presented for the quantitative determination of the content of active pharmaceutical ingredients of “Propolis-Derma” pharmaceutical compositions by the method of the reverse-phase high-performance liquid chromatography on the basis of milichrom A-02 chromatograph. Results and Discussion: By comparing the retention times and the values of spectral ratios of the peaks obtained with such data in the database of chromatograph, the presence of naftifine hydrochloride has been confirmed in the composition of the medicated product “Propolis-PNH,” chlorquinaldol and salicylic acid – in the composition of “Propolis-PSC,” and chlorhexidine digluconate – in “Propolis-PCD” composition. In addition, in each of five series of experimental samples, the presence of phenolic propolis compounds which are part of the propolis tincture has been established as one of the main active components of the pharmaceutical compositions offered. Conclusions: It has been defined that experimental data on the content of biologically active substances of pharmaceutical compositions “Propolis-PNH,” “Propolis-PSC,” and “Propolis-PCD” are well correlated with the composition of the medicated preparations developed and the literary data on the chemical structure and composition of the basic substances, and the method offered gives the possibility to carry out standardization of the composition of the medicine developed, namely, “Propolis-Derma.”
      PubDate: 2018-01-04
      Issue No: Vol. 10, No. 04 (2018)
       
  • Phytochemical and in vivo pharmacological evaluation of various extracts
           of Ficus racemosa L.

    • Authors: Divyash Singh
      Abstract: Background: Ficus racemosa Linn. (FR) is commonly known as gula fig/cluster fig. It is moderate sized avenue tree found throughout India either wild or cultivated for its fruits eaten by villagers. Objective: The main aim of the study was to evaluate the antidiabetic potential of various polar and non-polar extracts of leaves and bark of FR in animals. Materials and Methods: The crude drugs were extracted using various polar and non-polar solvents and preliminary phytochemical screening was performed for the presence of various phytocompounds. Diabetes was induced by a single I.P. injection of streptozotocin in normal control animals and treatment of different polar and non-polar extracts of leaves and bark of FR in diabetic animals. Blood glucose levels and various lipid parameters were evaluated in normal, diabetic, and various drug-treated animals. Results: In 21-day, glibenclamide as standard drug restored the blood glucose level and it is highly significantly(P < 0.001) in 14 days, where as methanolic extracts of FR (200 and 400 mg/kg) reduced the glucose level moderately and highly significant (P < 0.001). Petroleum ether, chloroform, ethyl acetate, and ethanolic extracts of FR had moderately significant effects (P < 0.01) on 14th and 21st days. Conclusion: This study reveals that methanolic extract of the plant is more effective in both cause of potential evaluation. In future, this plant can be used as antidiabetic and hypolipidemic drug for developing new pharmaceuticals and treatment of several diseases.
      PubDate: 2018-01-04
      Issue No: Vol. 10, No. 04 (2018)
       
  • Characteristics of 2-(tetrazol[1,5-c]quinazolin-5-ylthio) acetate effect
           on the level of adenine nucleotides in intense physical activity

    • Authors: Olena Toziuk
      Abstract: Introduction: We investigated changes in the energy state of the skeletal muscle cells in rats under physical load (15 days). Materials and Methods: The experiments were performed on nonlinear white rats. On the 15th day of the experiment, the rats were loaded with running at a speed of 42 m/min and slope angle 10°. The test substance sodium 2-(tetrazol[1,5-c]quinazolin-5-ylthio)acetate (compound КВ-28) at a dose of 1.7 mg/kg and reference compound 2-ethylthiobenzimidazole hydrobromide (32.0 mg/kg) were administered to animals intraperitoneally 60 min before treadmill training. Concentration of adenine nucleotides (ATP, ADP, and AMP) was determined in skeletal muscles by thin layer chromatography test. Results and Discussion: It was first found that a course of intraperitoneal injection of sodium 2-(tetrazol[1,5-c]quinazolin-5-ylthio)acetate (compound KB-28) contributed to 88.5% (P < 0.05) growth of physical endurance. We proved, that unlike the trained control, administration of compound KB-28 prevented imbalance in the system of adenine nucleotides. It was indicated by a significantly important increase of the level of ATP by 54.8% while parallel reducing concentration of ADP and AMP by 16.8 and 43.4%, respectively. Conclusions: Restoration of balance in the adenine nucleotides system may be one of the components of sodium 2-(tetrazol[1,5-c]quinazolin-5-ylthio)acetate (compound KB-28) actoprotective effect.
      PubDate: 2018-01-04
      Issue No: Vol. 10, No. 04 (2018)
       
  • Antiurolithiatic activity of Phaseolus vulgaris seeds against ethylene
           glycol-induced renal calculi in Wistar rats

    • Authors: K. V. S. R. G. Prasad
      Abstract: Objective: The present study was aimed to evaluate the antiurolithiatic potential of the ethanolic extract of the seed of Phaseolus vulgaris (EPV). Materials and Methods: Calcium oxalate urolithiasis in male Wistar rats was induced by ethylene glycol (EG) (0.75% v/v) and ammonium chloride (1% w/v) administration in drinking water. Cystone (750 mg/kg, p.o.) was used as a standard drug, and EPV was administered at doses of 200 and 400 mg/kg, p.o. Both preventive and curative effects of EPV were evaluated. Urinary biochemical parameters such as calcium, oxalate, phosphate, uric acid and creatinine; deposition of calcium and oxalate in the kidney; and serum uric acid, creatinine, and blood urea nitrogen (BUN) were assessed. Creatinine clearance was calculated. Oxalate associated oxidative stress in the kidney was assessed by estimating in vivo antioxidant parameters such as lipid peroxidation, superoxide dismutase, catalase, and reduced glutathione. Histopathological studies of the kidney were carried out. Results: In the preventive and curative disease-control groups, urinary excretion of calcium, oxalate, and their deposition in the kidney were significantly increased. Elevated levels of phosphate and uric acid in urine and uric acid, creatinine, and BUN in serum were observed in both the control groups. Creatinine clearance was reduced in the control groups. On treatment with cystone and EPV, all the urinary, serum biochemical, and oxidative stress parameters were reversed to almost normal values. Cystone and EPV significantly restored the in vivo antioxidant enzymes by decreasing the lipid peroxidation in the kidney. This study demonstrated the antiurolithiatic activity of the ethanolic extract of P. vulgaris seeds against EG-induced renal calculi in Wistar rats.
      PubDate: 2018-01-04
      Issue No: Vol. 10, No. 04 (2018)
       
 
 
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