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Publisher: Medknow Publishers   (Total: 425 journals)

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Showing 1 - 200 of 425 Journals sorted alphabetically
Acta Medica Intl.     Open Access   (SJR: 0.101, CiteScore: 0)
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advanced Biomedical Research     Open Access  
Advances in Human Biology     Open Access   (Followers: 4)
Advances in Skeletal Muscle Function Assessment     Open Access  
African J. for Infertility and Assisted Conception     Open Access   (Followers: 1)
African J. of Medical and Health Sciences     Open Access   (Followers: 3)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.25, CiteScore: 1)
African J. of Trauma     Open Access   (Followers: 1)
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 2)
Al-Azhar Assiut Medical J.     Open Access   (Followers: 2)
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Alexandria J. of Pediatrics     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 5)
Anesthesia : Essays and Researches     Open Access   (Followers: 10)
Annals of African Medicine     Open Access   (Followers: 2, SJR: 0.258, CiteScore: 1)
Annals of Bioanthropology     Open Access   (Followers: 5)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.308, CiteScore: 1)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery     Open Access  
Annals of Indian Psychiatry     Open Access  
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 12, SJR: 0.352, CiteScore: 1)
Annals of Saudi Medicine     Open Access   (SJR: 0.238, CiteScore: 1)
Annals of Thoracic Medicine     Open Access   (Followers: 6, SJR: 0.524, CiteScore: 1)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 13, SJR: 0.152, CiteScore: 0)
Annals of Tropical Pathology     Open Access  
Apollo Medicine     Open Access  
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access   (Followers: 1)
Archives of Cardiovascular Imaging     Open Access   (Followers: 2, SJR: 0.187, CiteScore: 0)
Archives of Intl. Surgery     Open Access   (Followers: 10, SJR: 0.302, CiteScore: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 4)
Archives of Medicine and Surgery     Open Access  
Archives of Pharmacy Practice     Open Access   (Followers: 10, SJR: 0.102, CiteScore: 0)
Archives of Trauma Research     Open Access   (Followers: 3, SJR: 0.37, CiteScore: 2)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 5)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.856, CiteScore: 2)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 2)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.35, CiteScore: 1)
Asian Pacific J. of Reproduction     Open Access   (SJR: 0.227, CiteScore: 1)
Asian Pacific J. of Tropical Biomedicine     Open Access   (Followers: 2, SJR: 0.491, CiteScore: 2)
Asian Pacific J. of Tropical Medicine     Open Access   (Followers: 1, SJR: 0.561, CiteScore: 2)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
Biomedical and Biotechnology Research J.     Open Access   (Followers: 1)
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access   (Followers: 1)
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 2)
Canadian J. of Rural Medicine     Full-text available via subscription   (Followers: 1, SJR: 0.202, CiteScore: 0)
Cancer Translational Medicine     Open Access   (Followers: 2)
Cardiology Plus     Open Access   (Followers: 1)
Chinese Medical J.     Open Access   (Followers: 10, SJR: 0.52, CiteScore: 1)
CHRISMED J. of Health and Research     Open Access   (Followers: 2)
Clinical Cancer Investigation J.     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 4)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 8, SJR: 0.811, CiteScore: 2)
Contemporary Clinical Dentistry     Open Access   (Followers: 5, SJR: 0.353, CiteScore: 1)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.543, CiteScore: 1)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 4, SJR: 0.152, CiteScore: 0)
Dental Research J.     Open Access   (Followers: 13, SJR: 0.416, CiteScore: 1)
Dentistry and Medical Research     Open Access   (Followers: 1)
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 7, SJR: 0.242, CiteScore: 0)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1, SJR: 1.799, CiteScore: 2)
Egyptian J. of Chest Diseases and Tuberculosis     Open Access   (Followers: 3, SJR: 0.155, CiteScore: 0)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 1)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Nursing J.     Open Access  
Egyptian Orthopaedic J.     Open Access   (Followers: 2)
Egyptian Pharmaceutical J.     Open Access   (Followers: 3)
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access   (Followers: 2)
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.822, CiteScore: 2)
Environmental Disease     Open Access   (Followers: 4)
Eurasian J. of Pulmonology     Open Access  
European J. of Dentistry     Open Access   (Followers: 4, SJR: 0.749, CiteScore: 2)
European J. of General Dentistry     Open Access   (Followers: 2, SJR: 0.12, CiteScore: 0)
European J. of Prosthodontics     Open Access   (Followers: 4)
European J. of Psychology and Educational Studies     Open Access   (Followers: 11, SJR: 0.113, CiteScore: 0)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.112, CiteScore: 0)
Genome Integrity     Open Access   (Followers: 2, SJR: 0.153, CiteScore: 0)
Glioma     Open Access  
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Gynecology and Minimally Invasive Therapy     Open Access   (SJR: 0.311, CiteScore: 1)
Hamdan Medical J.     Open Access  
Heart and Mind     Open Access  
Heart India     Open Access   (Followers: 2)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
Ibnosina J. of Medicine and Biomedical Sciences     Open Access   (Followers: 1)
IJS Short Reports     Open Access  
Imam J. of Applied Sciences     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.478, CiteScore: 1)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (Followers: 1, SJR: 0.361, CiteScore: 1)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.37, CiteScore: 1)
Indian J. of Dental Research     Open Access   (Followers: 5, SJR: 0.266, CiteScore: 1)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.468, CiteScore: 1)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 4, SJR: 0.445, CiteScore: 1)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1, SJR: 0.791, CiteScore: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4, SJR: 0.568, CiteScore: 1)
Indian J. of Health Sciences and Biomedical Research KLEU     Open Access   (Followers: 3)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.425, CiteScore: 1)
Indian J. of Medical Microbiology     Open Access   (Followers: 2, SJR: 0.503, CiteScore: 1)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.656, CiteScore: 1)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.102, CiteScore: 0)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.347, CiteScore: 1)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.23, CiteScore: 0)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 3, SJR: 0.225, CiteScore: 1)
Indian J. of Ophthalmology     Open Access   (Followers: 4, SJR: 0.498, CiteScore: 1)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 8, SJR: 0.392, CiteScore: 1)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.199, CiteScore: 0)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 2)
Indian J. of Palliative Care     Open Access   (Followers: 6, SJR: 0.454, CiteScore: 1)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 3, SJR: 0.276, CiteScore: 1)
Indian J. of Pharmacology     Open Access   (SJR: 0.412, CiteScore: 1)
Indian J. of Psychiatry     Open Access   (Followers: 2, SJR: 0.408, CiteScore: 1)
Indian J. of Psychological Medicine     Open Access   (SJR: 0.368, CiteScore: 1)
Indian J. of Public Health     Open Access   (Followers: 1)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Respiratory Care     Open Access  
Indian J. of Rheumatology     Open Access   (Followers: 1, SJR: 0.119, CiteScore: 0)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.34, CiteScore: 0)
Indian J. of Social Psychiatry     Open Access   (Followers: 1)
Indian J. of Transplantation     Open Access  
Indian J. of Urology     Open Access   (Followers: 4, SJR: 0.434, CiteScore: 1)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Indian Spine J.     Open Access  
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intervention     Open Access   (Followers: 1)
Intl. Archives of Health Sciences     Open Access  
Intl. J. of Abdominal Wall and Hernia Surgery     Open Access   (Followers: 1)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Clinicopathological Correlation     Open Access   (Followers: 1)
Intl. J. of Community Dentistry     Open Access  
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1, SJR: 0.192, CiteScore: 0)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 8, SJR: 0.142, CiteScore: 0)
Intl. J. of Growth Factors and Stem Cells in Dentistry     Open Access  
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 6)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.535, CiteScore: 1)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4, SJR: 0.17, CiteScore: 0)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 3)
Intl. J. of Orofacial Biology     Open Access   (Followers: 1)
Intl. J. of Orofacial Research     Open Access   (Followers: 2)
Intl. J. of Orthodontic Rehabilitation     Open Access   (Followers: 1)
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 2)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.623, CiteScore: 1)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 5, SJR: 0.653, CiteScore: 1)
Intl. J. of the Cardiovascular Academy     Open Access   (SJR: 0.105, CiteScore: 0)
Intl. J. of Trichology     Open Access   (SJR: 0.4, CiteScore: 1)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 3)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Acute Disease     Open Access   (SJR: 0.163, CiteScore: 1)

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Journal Cover
Indian Journal of Pathology and Microbiology
Journal Prestige (SJR): 0.276
Citation Impact (citeScore): 1
Number of Followers: 3  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0377-4929 - ISSN (Online) 0974-5130
Published by Medknow Publishers Homepage  [425 journals]
  • From Editor's desk

    • Authors: Ranjan Agrawal
      Pages: 521 - 522
      Abstract: Ranjan Agrawal
      Indian Journal of Pathology and Microbiology 2019 62(4):521-522

      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):521-522
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/0377-4929.269091
      Issue No: Vol. 62, No. 4 (2019)
       
  • p16 as an independent marker for detection of high-risk HPV in oral
           submucous fibrosis and oral squamous cell carcinoma

    • Authors: Archana Sudhakaran, Kaveri Hallikeri, Biji Babu
      Pages: 523 - 528
      Abstract: Archana Sudhakaran, Kaveri Hallikeri, Biji Babu
      Indian Journal of Pathology and Microbiology 2019 62(4):523-528
      Background: An alarming increase in incidence of high-risk human papillomavirus (HPV) positive tumors in head and neck squamous cell carcinoma (HNSCC) by 25% and 70% in oropharyngeal HNSCC cannot be ignored. The early oncogenes of HPV, E6, and E7 play a key role in carcinogenesis. HPV associated tumors have a better clinical outcome and a favorable prognosis. The p16 expression has high concordance with other methods of HPV detection, ascertaining p16 as a surrogate marker for HPV. Objective: To assess the immunohistochemical expression of p16 in oral submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC) with and without coexistent OSF as a marker for high-risk HPV detection. Materials and Methods: Tissue blocks of 70 cases including normal, OSF, OSCC with and without OSF were subjected to IHC staining with a p16INK4A monoclonal antibody. (Biogenex, San Roman). The p16 expression was noted according to percent positivity and pattern. The data were tabulated, statistically analyzed using the Chi-square test and the P value was assessed. Results: The percentage of p16 positive cells raised from normal to OSF to OSCC with and without OSF. In addition, a shift from nuclear to cytoplasmic expression from normal to OSCC was noted with a statistical significance (P < 0.001). However, no statistical significance was established with any clinicopathologic parameters except age (P = 0.012) and habits (P= 0.023). Conclusion: The presence of HPV using p16 was not detected in OSF but was positive in OSCC. Altered pattern of expression from normal to OSF to OSCC indicates promising use of p16 as a diagnostic marker.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):523-528
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_838_18
      Issue No: Vol. 62, No. 4 (2019)
       
  • Omics data-driven analysis identifies laminin-integrin-mediated signaling
           pathway as a determinant for cell differentiation in oral squamous cell
           carcinoma

    • Authors: Spoorti Kulkarni, Riaz Abdulla, Maji Jose, Soniya Adyanthaya, DA B Rex, Arun H Patil, Sneha M Pinto, Yashwanth Subbannayya
      Pages: 529 - 536
      Abstract: Spoorti Kulkarni, Riaz Abdulla, Maji Jose, Soniya Adyanthaya, DA B Rex, Arun H Patil, Sneha M Pinto, Yashwanth Subbannayya
      Indian Journal of Pathology and Microbiology 2019 62(4):529-536
      Background: In recent years, high-throughput omics technologies have been widely used globally to identify potential biomarkers and therapeutic targets in various cancers. However, apart from large consortiums such as The Cancer Genome Atlas, limited attempts have been made to mine existing datasets pertaining to cancers. Methods and Results: In the current study, we used an omics data analysis approach wherein publicly available protein expression data were integrated to identify functionally important proteins that revealed consistent dysregulated expression in head and neck squamous cell carcinomas. Our analysis revealed members of the integrin family of proteins to be consistently altered in expression across disparate datasets. Additionally, through association evidence and network analysis, we also identified members of the laminin family to be significantly altered in head and neck cancers. Members of both integrin and laminin families are known to be involved in cell-extracellular matrix adhesion and have been implicated in tumor metastatic processes in several cancers. To this end, we carried out immunohistochemical analyses to validate the findings in a cohort (n = 50) of oral cancer cases. Laminin-111 expression (composed of LAMA1, LAMB1, and LAMC1) was found to correlate with cell differentiation in oral cancer, showing a gradual decrease from well differentiated to poorly differentiated cases. Conclusion: This study serves as a proof-of-principle for the mining of multiple omics datasets coupled with selection of functionally important group of molecules to provide novel insights into tumorigenesis and cancer progression.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):529-536
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_1_19
      Issue No: Vol. 62, No. 4 (2019)
       
  • Collagen fibers in oral submucous fibrosis - A polarizing microscopy study
           using two special stains

    • Authors: Roquaiya Nishat, Harish Kumar
      Pages: 537 - 543
      Abstract: Roquaiya Nishat, Harish Kumar
      Indian Journal of Pathology and Microbiology 2019 62(4):537-543
      Background: Oral submucous fibrosis (OSMF), a well-recognized oral potentially malignant disorder, results due to increased collagen production and reduced collagen degradation. Aims and Objectives: To qualitatively compare the staining properties of collagen in OSMF using two special stains based on their birefringent property using polarizing microscopy. The study also assessed the distribution and orientation of collagen fibers in different grades of OSMF. Materials and Methods: A total of 73 subjects with different clinical and histopathological staging of OSMF comprised the study population. Histopathological examination was done using hematoxylin and eosin stain, Van Gieson and picrosirius red. Collagen fibers were analyzed for polarization colors, distribution, and orientation. Results: Picrosirius red stained both thick and thin collagen fibers. Irrespective of the histopathological grades reddish orange and yellowish orange were the most predominant colors. Parallel arrangement of fibers was observed when stained with Van Gieson but picrosirius red stained sections showed a majority of parallel type I fibers with perpendicular type III fibers which increased with advancement in the histopathological grade. Yellowish orange and greenish yellow fibers were predominant in the lamina propria, while reddish orange fibers were predominant in the submucosa. Conclusion: Picrosirius red was found to be a better stain. Histopathological grading and polarization colors showed no association with each other. Collagen fibers were more thickly and tightly packed in the submucosa indicating that the process of fibrosis began there. The increase in perpendicular type III fibers with advancing histopathological grades suggested their role in fibrosis.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):537-543
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_324_19
      Issue No: Vol. 62, No. 4 (2019)
       
  • Risk of malignancy in Thyroid “Atypia of undetermined
           significance/Follicular lesion of undetermined significance” and its
           subcategories – A 5-year experience

    • Authors: Abha Thakur, Haimanti Sarin, Dilpreet Kaur, Deepak Sarin
      Pages: 544 - 548
      Abstract: Abha Thakur, Haimanti Sarin, Dilpreet Kaur, Deepak Sarin
      Indian Journal of Pathology and Microbiology 2019 62(4):544-548
      Context: Atypia of undetermined significance/Follicular lesion of undetermined significance [AUS/FLUS] is a heterogeneous category with a wide range of risk of malignancy [ROM] reported in the literature. The Bethesda system for reporting thyroid cytopathology [TBSRTC], 2017 has recommended subcategorization of AUS/FLUS. Aims: To evaluate the ROM in thyroid nodules categorized as AUS/FLUS, as well as separate ROM for each of the five subcategories. Settings and Design: Retrospective analytic study. Methods and Materials: A retrospective audit was conducted for all thyroid fine-needle aspiration cytology (FNAC) from January 2013 to December 2017. Slides for cases with follow-up histopathology were reviewed, classified into the five recommended subcategories, and differential ROM was calculated. Statistical Analysis Used: z test for comparison of proportions was done to evaluate the difference in ROM among different subcategories of AUS/FLUS. The P value of less than 0.05 was taken as statistically significant. Results: Total number of thyroid FNACs reported was 1,630, of which 122 were AUS/FLUS (7.5%). Histopathology was available in 49 cases, out of which 18 were malignant (ROM = 36.7%). The risk of malignancy (ROM) for nodules with architectural and cytologic atypia was higher (43.8%) than ROM for nodules with only architectural atypia (16.7%). Conclusions: The sub-classification of AUS/FLUS into subcategories as recommended by TBSRTC, 2017 may better stratify the malignancy risk and guide future management guidelines.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):544-548
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_319_19
      Issue No: Vol. 62, No. 4 (2019)
       
  • Loss of c-Cbl expression correlates with de-differentiation status and
           lymphatic metastasis in gastric cancer

    • Authors: Chuchu Chen, Yi Hui, Yunzhao Chen, Chengjia Qian, Minxuan Sun
      Pages: 549 - 555
      Abstract: Chuchu Chen, Yi Hui, Yunzhao Chen, Chengjia Qian, Minxuan Sun
      Indian Journal of Pathology and Microbiology 2019 62(4):549-555
      Context: C-Cbl is an important negative regulator of the cell signaling that acts as an adaptor protein and E3 ubiquitin ligase. The role of c-Cbl in development and regulation of human cancer has aroused intensive attention. Aims: In this study, we aimed to assess the correlation between the expression of c-Cbl and clinicopathological parameters and explored the role of c-Cbl in the development and progression of GC. Settings and Design: This is a Pilot study. Methods and Materials: In total, 84 tissue samples including 44 gastric cancers (GC) and 40 matched adjacent normal tissues were collected after surgery. Then tissue microarray (TMA) and immunohistochemistry (IHC) technology were combined to detect the protein expression of c-Cbl. Statistical Analysis Used: Statistical analysis was performed using SPSS 22.0 (IBM Corporation, Armonk, NY, USA). Results: We have studied the correlation between c-Cbl expression and clinicopathological parameters. Our study showed that c-Cbl has a low expression in 61.4% (27/44) of GC tissues, and the incidence of cases was significantly higher than that in adjacent normal tissues (P < 0.0001). In addition, the correlation between c-Cbl expression and gastric carcinoma subtype (P = 0.027), histological type (P = 0.033), Borrmann classification (P = 0.009), histological differentiation (P = 0.0005), lymph node metastasis (P = 0.007), and intravascular tumor thrombus (P = 0.036) has also been revealed. Conclusions: Our results show that c-Cbl is down-regulated in GC tissues compared with normal gastric tissue, which may play an important role in the development and progression of GC.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):549-555
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_824_18
      Issue No: Vol. 62, No. 4 (2019)
       
  • Clinicopathological profile of hepatoblastoma: An experience from a
           tertiary care center in India

    • Authors: B Archana, J Thanka, Latha M Sneha, J Julius Xavier Scott, M Arunan, Prakash Agarwal
      Pages: 556 - 560
      Abstract: B Archana, J Thanka, Latha M Sneha, J Julius Xavier Scott, M Arunan, Prakash Agarwal
      Indian Journal of Pathology and Microbiology 2019 62(4):556-560
      Background: Hepatoblastoma is the most common primary hepatic malignancy in the pediatric population. Advances in pathological evaluation, imaging, risk stratification, neo-adjuvant chemotherapy, and surgery including transplantation have improved survival of these children in the western countries. However, a successful outcome in developing countries such as India with limited resources poses great challenges to the clinician and the family. Histology plays a major role in determining the prognosis of these patients. Methods: A retrospective study was done on 10 children diagnosed with hepatoblastoma between January 2010 and December 2015 in our institution. Clinical, laboratory, radiological, histopathological diagnoses, treatment, and outcome data were collected and analyzed. Results: The median age of these children at diagnosis was 11 months, and only 1 child was premature at birth. Most children were presented with abdominal distension. One child had lung metastasis at presentation. Elevated alpha fetoprotein levels were present in 90% of the children. The histological types were fetal, embryonal, macrotrabecular, and mixed epithelial-mesenchymal types. SIOPEL risk stratification was done, which showed 40% of the children to be of high risk. Three children had PRETEXT 1, 2, and 4, respectively. Conclusion: Our study is significant with respect to the information on PRETEXT staging, risk status, and histological favorability. In developing countries with limited resources and low-socioeconomic status, it is important to have a multidisciplinary team approach and tailor treatment to manage these patients effectively and improve the overall survival.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):556-560
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_200_19
      Issue No: Vol. 62, No. 4 (2019)
       
  • The role of p53, Ki-67 and laminin expression in the differential
           diagnosis of keratoacanthoma and well-differentiated SCC

    • Authors: Gulay Turan, Eren Altun, Figen Aslan, Ozgur Kulahci
      Pages: 561 - 565
      Abstract: Gulay Turan, Eren Altun, Figen Aslan, Ozgur Kulahci
      Indian Journal of Pathology and Microbiology 2019 62(4):561-565
      Introduction: We have aimed to evaluate the difference between the expression of p53, Ki-67, and laminin in keratoacanthoma and well-differentiated SCC (SCC) and to determine its importance in differential diagnosis. Methods: This study totally included 46 cases consisting of 23 cases with keratoacanthoma and 23 with SCC. As well as age, gender, localization, and diameter of the lesion, the expression of p53, Ki-67 and laminin was evaluated. Results: No statistically significant difference was found between KA and well-differentiated SCC in terms of diameter, age, and localization. There was a statistically significant difference between KA and well-differentiated SCC in terms of p53 and Ki-67 staining (P < 0.001). Increased expression of p53 and Ki-67 was found in well-differentiated SCC. A statistically significant correlation was present between the expression of p53 and Ki-67 in KA. A statistically significant difference was detected between KA and well-differentiated SCC in terms of laminin staining (P = 0.018). Increased laminin expression was determined in well-differentiated SCC. Conclusion: We have determined in this study that p53, Ki-67 and laminin may be used as adjuvant immunohistochemical markers in differential diagnosis of KA and well-differentiated SCC.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):561-565
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_752_18
      Issue No: Vol. 62, No. 4 (2019)
       
  • Morphological characterization and molecular profiling of malignant
           pericardial effusion in patients with pulmonary adenocarcinoma

    • Authors: Bing Zhou, Lin Li, Dayou Shi, Tao Jiang, Guohui Xue, Jianping Xiong
      Pages: 566 - 571
      Abstract: Bing Zhou, Lin Li, Dayou Shi, Tao Jiang, Guohui Xue, Jianping Xiong
      Indian Journal of Pathology and Microbiology 2019 62(4):566-571
      Context: Malignant pericardial effusions (MPCEs) is a common complication observed in advanced pulmonary adenocarcinoma. In such cases, investigating molecular alterations can have significant therapeutic implication in determining anticancer drugs. Aim: The objective was to evaluate the significance of cell block technique in the diagnosis of MPCE and further investigate the morphological and molecular profiles of MPCE in patients with pulmonary adenocarcinoma. Setting and Design: Cytopathological and molecular profiles of 19 MPCE cases in patients with pulmonary adenocarcinoma were retrospectively analyzed. The control group consisted of 14 malignant pleural effusion (MPE) cases in patients with pulmonary adenocarcinoma. Materials and Methods: Anaplastic lymphoma kinase (ALK) and tyrosine-protein kinase Met (C-MET) expression was evaluated by fluorescence in situ hybridization (FISH). Epithelial growth factor receptor (EGFR) and K-Ras (KRAS) mutations were detected by ARMS real-time polymerase chain reaction (RT-PCR). Statistical Analysis Used: Associations between MPCE and MPE were analyzed using Fisher's exact test. Results: MPCE was found to have micropapillary and solid pattern predominant with mucin secretion compared to acinar patterns, as seen in MPE. Seventeen MPCE cases (89.5%) and all MPE cases (100%) underwent molecular analysis. Mutations in EGFR and KRAS, ALK rearrangement, and C-MET amplification were observed in MPCE and MPE with statistical differences. Additionally, two MPCE cases demonstrated EGFR T790M mutation and multiple insertions at L858. Conclusions: MPCE shows micropapillary and solid cytological patterns predominant with mucin secretion. MPCE are suitable to analyze oncogenic mutations and to develop targeted therapy for patients with pulmonary adenocarcinoma. Further molecular investigations may reveal novel molecular alterations.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):566-571
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_69_19
      Issue No: Vol. 62, No. 4 (2019)
       
  • Evaluation of high-fluorescence body fluid (HF-BF) parameter as a
           screening tool of malignancy in body fluids

    • Authors: Loveena Rastogi, Jasmita Dass, Vandana Arya, Jyoti Kotwal
      Pages: 572 - 577
      Abstract: Loveena Rastogi, Jasmita Dass, Vandana Arya, Jyoti Kotwal
      Indian Journal of Pathology and Microbiology 2019 62(4):572-577
      Introduction: Automated body fluid (BF) analysis is gradually replacing the traditional methods of cell counting in all BFs. This study was done to analyze the high-fluorescence (HF)-BF parameter generated on Sysmex XN-1000 and study its correlation with the presence of malignant cells in the body fluids. A correlation between manual and automated differential counts was also done. Materials and Methods: A total of 1985 samples including 797 ascitic fluids (AF), 532 pleural fluids (PF), and 656 cerebrospinal fluids (CSF) were run on Sysmex XN-1000 in BF mode and cytopathology was available for 924 BFs including 389 AF, 379 PF, and 156 CSF. Both manual and automated methods were used for cell differential and cell morphology. Results: Of the 924 samples with corresponding cytopathology, malignancy was found in 59 samples. The HF-BF%/100 WBCs (24.8 ± 72.5) and HF-BF#/μL (329.86 ± 932.35) for malignant BF samples were found to be significantly higher than the nonmalignant samples (4.41 ± 8.1) and (19.57 ± 61.91), respectively. Receiver–operator-characteristic curve cutoffs for all BF for percentage and absolute HF-BF were 2.85%/100 WBCs and >12/μL. A good correlation was found between the manual and automated WBC differential counts in all fluids except CSF with total count
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):572-577
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_802_18
      Issue No: Vol. 62, No. 4 (2019)
       
  • Role of procalcitonin, Il-6 and C- reactive protein in suspected cases of
           sepsis

    • Authors: Shiwangi Sharma, Nandini Duggal
      Pages: 578 - 581
      Abstract: Shiwangi Sharma, Nandini Duggal
      Indian Journal of Pathology and Microbiology 2019 62(4):578-581
      Objectives: To study the role of serum procalcitonin as a diagnostic biomarker in sepsis and to compare it with other sepsis markers (IL-6, CRP) in patients of suspected sepsis. Materials and Methods: A total of 80 patients were included in this study from ICU and each patient was investigated for serum Procalcitonin, Interleukin-6 and C-reactive protein levels by ELISA along with blood cultures by BacT/Alert system. Result: Procalcitonin along with CRP is a better diagnostic tool for sepsis.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):578-581
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_762_18
      Issue No: Vol. 62, No. 4 (2019)
       
  • Metastatic hepatocellular carcinoma to the parotid gland: A diagnostic
           dilemma with review of the literature

    • Authors: Hema Malini Aiyer, Sanjay Deb, Garima Rawat
      Pages: 582 - 585
      Abstract: Hema Malini Aiyer, Sanjay Deb, Garima Rawat
      Indian Journal of Pathology and Microbiology 2019 62(4):582-585
      Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy and is a leading cause of cancer-related death worldwide. It has a very aggressive clinical course, with a mean survival rate of much less than a year if left untreated. Here, we present a case of a 68-year-old male with progressively enlarging painful right facial swelling, involving the ramus and condyle of mandible on contrast-enhanced computed tomography mimicking an osteosarcoma. Eventually, the final diagnosis of HCC metastatic to the right parotid gland was made. We report a case of a rare metastasis of HCC to the parotid gland. Furthermore, the present case demonstrates the importance of tissue biopsy and immunohistochemistry for obtaining an accurate final diagnosis.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):582-585
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_272_19
      Issue No: Vol. 62, No. 4 (2019)
       
  • Primary epiglottic follicular variant of peripheral T-cell lymphoma

    • Authors: Jienan Kong, Lin Zhong, Xue Gao, Wenjing Qi, Lizhi Zhang, Zhenhua Lin
      Pages: 586 - 588
      Abstract: Jienan Kong, Lin Zhong, Xue Gao, Wenjing Qi, Lizhi Zhang, Zhenhua Lin
      Indian Journal of Pathology and Microbiology 2019 62(4):586-588
      The follicular variant of peripheral T-cell lymphoma, not otherwise specified, is very rare. Primary epiglottic follicular variant of peripheral T-cell lymphoma is extremely rare in clinical practice. Here, we report the first case of a follicular variant of peripheral T-cell lymphoma not otherwise specified in a 44-year-old Chinese man, who presented with a tumor in the middle of the epiglottis tongue surface. Microscopically, the tumor had a vague nodular growth pattern and the morphology of the nodules was different from each other at low power. Atypical lymphoid cells were medium to large in size and had round nuclei, with an irregular nuclear membrane, distinct nucleoli, and rapid mitotic activity. Plasma cells were found surrounding the nodules. The tumor cells were positive for follicular helper T-cell markers (CD10, PD-1, CXCL13, and BCL-6). The EBER was negative by in situ hybridization. Polymerase chain reaction-based analysis showed monoclonal rearrangements of TCRβ, TCRγ, and polyclonal rearrangements of IgH, IgK, and IgL. The clinical and imaging features and the prognostic factors of FV PTCL-NOS remain poorly understood. Thus, investigation of more cases and longer follow-up is necessary to understand the disease and to identify the best treatment to improve prognosis.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):586-588
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_849_18
      Issue No: Vol. 62, No. 4 (2019)
       
  • Fever work-up unfolds a rare diagnosis of native valve endocarditis caused
           by Mycobacterium abscessus

    • Authors: Anita Sharma, Irneet Mundi, Karun Behal, Navreet Kaur, Pooja Singh, Manish Mahant
      Pages: 589 - 591
      Abstract: Anita Sharma, Irneet Mundi, Karun Behal, Navreet Kaur, Pooja Singh, Manish Mahant
      Indian Journal of Pathology and Microbiology 2019 62(4):589-591
      Endocarditis caused by Mycobacterium abscessus is rare and often missed without appropriate blood cultures. It does not respond to standard antitubercular treatment and is also resistant to many other antibiotics. The course of the disease may be indolent and often results in a fatal outcome. Accurate identification and sensitivity, combination therapy, and prolonged duration of antibiotics are, therefore, important for a successful outcome.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):589-591
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_19_19
      Issue No: Vol. 62, No. 4 (2019)
       
  • Sympathetic ophthalmia with incidental finding of chicken pox supported by
           histopathology and immunohistochemistry

    • Authors: Dipankar Das, Subramanium Krishnakumar, Jyotirmay Biswas
      Pages: 592 - 594
      Abstract: Dipankar Das, Subramanium Krishnakumar, Jyotirmay Biswas
      Indian Journal of Pathology and Microbiology 2019 62(4):592-594
      Sympathetic ophthalmia (SO) is a rare bilateral diffuse granulomatous panuveitis that occurs in few days to several years after penetrating injury. This intraocular inflammation can occur in any age group without a sex predilection. Pathology and immunohistochemistry-supported evidence is important to know the disease in a better way. We present a case of a 24-year-old female with clinical diagnosis of SO with an atypical past history of chicken pox in that eye and residual corneal opacity.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):592-594
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_192_19
      Issue No: Vol. 62, No. 4 (2019)
       
  • Type I pleuropulmonary blastoma presenting as congenital pulmonary airway
           malformation: A report of two cases

    • Authors: Kalpana Kumari, Moanaro Longchar, Ganganath Gunathilaka, Priyanka Narange, Sandeep Aggarwal, Sudheer Arava
      Pages: 595 - 598
      Abstract: Kalpana Kumari, Moanaro Longchar, Ganganath Gunathilaka, Priyanka Narange, Sandeep Aggarwal, Sudheer Arava
      Indian Journal of Pathology and Microbiology 2019 62(4):595-598
      Pleuropulmonary blastoma (PPB) is a rare aggressive intrathoracic tumor which is believed to originate from embryonic uncommitted lung mesenchymal cells, which are important for developing the lung. Type I PPB is cystic, type II is cystic and solid, while type III is predominantly solid. Diagnosing type 1 PPB is a challenge for both radiologists as well as pathologists. Owing to its purely cystic nature, type I PPB it is often mistaken for unrelated entities such as congenital pulmonary airway malformation and congenital lobar emphysema which delays surgical intervention. Here, we report two such cases presenting clinically and radiologically as congenital pulmonary airway malformation. On histology, a final diagnosis of type I pleuropulmonay blastoma was made. Thereafter, chemotherapy was administered following complete surgical excision.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):595-598
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_713_18
      Issue No: Vol. 62, No. 4 (2019)
       
  • Cardiac myxoma with cartilaginous differentiation-An uncommon variant
           presented as mitral stenosis

    • Authors: Sunil V Jagtap, Pravin Salunkhe, Avinash Mane, Sujata Kumbhar, Purva Mayekar, Saswati Boral
      Pages: 599 - 601
      Abstract: Sunil V Jagtap, Pravin Salunkhe, Avinash Mane, Sujata Kumbhar, Purva Mayekar, Saswati Boral
      Indian Journal of Pathology and Microbiology 2019 62(4):599-601
      The estimated incidence of primary cardiac tumors is extremely rare. Among it, cardiac myxoma represents the most common benign cardiac tumor constituting about 80% of cases. We are presenting a 30–year-old female with large left atrial myxoma. She was presented with severe dyspnea, palpitations, and systolic murmurs. On 2D echocardiography, left atrial mass obstructing mitral flow was noted. On cardiac magnetic resonance imaging, a single, large, mobile pedunculated mass lesion in left atrium attached to inferior interatrial septum with heterogeneous enhancement was noted, which was likely represented to be myxoma. The mass was surgically excised and valve repairing was done. We received large, solid, lobulated, gray white, soft-to-firm mass measuring 4.5 × 4.1 × 2.5 cm, and on microscopy showed cardiac myxoma with cartilaginous differentiation. We are presenting this case for its clinical, imaging, and uncommon histological features.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):599-601
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_281_19
      Issue No: Vol. 62, No. 4 (2019)
       
  • Myeloid sarcoma of bile ducts presenting as obstructive jaundice
           &#8211; A case report

    • Authors: Ayushi Agarwal, Tina Dadu, VP Bhalla, Veena Malhotra
      Pages: 602 - 604
      Abstract: Ayushi Agarwal, Tina Dadu, VP Bhalla, Veena Malhotra
      Indian Journal of Pathology and Microbiology 2019 62(4):602-604
      Myeloid sarcoma is an extra medullary manifestation of acute myeloid leukemia (AML). Primary involvement of the biliary tract with myeloid sarcoma presenting as obstructive jaundice without evidence of leukemia is very rare. Here we present a case of 72 year old lady, who initially presented with features of biliary obstruction and was clinically considered as cholangiocarcinoma. She was diagnosed as myeloid sarcoma involving right and left hepatic duct, common bile duct (CBD) on histopathological and immunohistochemistry (IHC) examination after surgical resection. Since she did not show evidence of leukemia on peripheral blood and bone marrow examination treatment was deferred. However, she developed full blown picture of AML within two months and succumbed to her disease. We conclude that obstructive jaundice can be the presenting symptom in myeloid sarcoma without evidence of AML in peripheral blood and bone marrow. However, these cases have to be treated aggressively to obtain remission.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):602-604
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_371_18
      Issue No: Vol. 62, No. 4 (2019)
       
  • Primary epithelial splenic cyst: A rare encounter

    • Authors: Pooja Sharma Kala, Sheenam Azad, Trisha Sharma, Seema Acharya
      Pages: 605 - 607
      Abstract: Pooja Sharma Kala, Sheenam Azad, Trisha Sharma, Seema Acharya
      Indian Journal of Pathology and Microbiology 2019 62(4):605-607
      Splenic cysts are rare with an overall incidence of 0.07% in a large autopsy series and 0.5% among all the splenectomies done. The parasitic splenic cysts, usually caused by Echinococcus granulosus, account for 60% of all primary splenic cysts. The primary epithelial cysts account for 10% of all splenic cysts. We report a case of 30-year-old female presenting with left upper abdominal pain and heaviness. Computed tomography revealed a multiloculated cyst in spleen. Hydatid serology was negative. Total splenectomy was done. Histopathological evaluation was done and a diagnosis of primary epithelial splenic cyst was given.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):605-607
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_335_19
      Issue No: Vol. 62, No. 4 (2019)
       
  • &#8220;Endolymphatic sac tumour&#8221;: A case report with
           review of literature

    • Authors: B Rajeshwari, Salapathi Shanmugam, Niamath Sadiya, Ghosh Mitra, B Chendilnathan
      Pages: 608 - 610
      Abstract: B Rajeshwari, Salapathi Shanmugam, Niamath Sadiya, Ghosh Mitra, B Chendilnathan
      Indian Journal of Pathology and Microbiology 2019 62(4):608-610
      Endolymphatic sac tumour (ELST) is a non-metastasizing low grade adenocarcinoma of endolymphatic sac origin. It is also known as Heffner tumour, low grade adenocarcinoma of endolymphatic sac origin and aggressive papillary middle ear tumour. These tumours are closely associated with Von Hippel Lindau (VHL) disease. Here we report a case of Endolymphatic sac tumour in a 63 yr old lady who presented with left sided facial palsy. Since the tumour was highly vascular and required preoperative embolization, initial clinicoradiological diagnosis was Jugulotymphanic paraganglioma. Histopathology showed features of Endolymphatic sac tumour, which was confirmed by immunohistochemistry. Since this tumour is locally aggressive low grade adenocarcinoma, the diagnosis is difficult in advanced cases where there is erosion of petrous temporal bone or the lesion shows extension into cerebellopontine angle as in our case. Since the association of this tumour with VHL disease is well established, it is important to screen all the patients of VHL disease for this lesion and also all the patients of ELST should be screened for other lesions of VHL disease to aid in early diagnosis and treatment. The case is presented here for its rarity and difficulty in initial diagnosis.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):608-610
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_345_18
      Issue No: Vol. 62, No. 4 (2019)
       
  • Tale of a mermaid

    • Authors: Pranjali Vasisht, Manoj G Madakshira, Nandita Kakkar, Veenu Singla, Vanita Jain
      Pages: 611 - 613
      Abstract: Pranjali Vasisht, Manoj G Madakshira, Nandita Kakkar, Veenu Singla, Vanita Jain
      Indian Journal of Pathology and Microbiology 2019 62(4):611-613
      Sirenomelia is a rare congenital anomaly characterized by the presence of a median single lower appendage. The affected fetus is popularly referred to as a “Mermaid baby,” due to the uncanny resemblance to the fictious fable character. The manifestation is a result of the merger of the lower limbs with variable fusion or complete absence of bones. Sirenomelia is universally fatal due to the associated lethal anomalies involving the internal organs, which are usually part of the VACTER or VACTERL complex. However, this sirenomelia-afflicted fetus is unique in being associated with VACTERL as well as congenital hydrocephalus.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):611-613
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_668_18
      Issue No: Vol. 62, No. 4 (2019)
       
  • FLI1 and MIC2 expression in precursor B-lymphoblastic leukemia with
           Burkitt-like morphology and extensive extramedullary involvement: A
           diagnostic challenge in pediatric small round cell tumor

    • Authors: Nupur Das, Deepshi Thakral, Geetika Singh, Ankit Malhotra, Ravi Hari Phulware, Ajay Gogia, Ritu Gupta
      Pages: 614 - 617
      Abstract: Nupur Das, Deepshi Thakral, Geetika Singh, Ankit Malhotra, Ravi Hari Phulware, Ajay Gogia, Ritu Gupta
      Indian Journal of Pathology and Microbiology 2019 62(4):614-617
      Pediatric small round cell tumors (PSRCTs) constitute a large proportion of childhood malignancies with overlapping diagnostic and clinical features but radically different therapies. Here, we report a case of 16-year-old male child presenting with diffuse abdominal and mediastinal mass, axillary lymphadenopathy, and pleural effusion. Bone marrow aspirate showed near total replacement by small round malignant cells. The bone marrow biopsy showed interstitial infiltration by malignant cells, which were CD45− CD3− CD20− MIC2+ FLI1+ and diagnosis of Ewing's sarcoma was established. In contrast, flowcytometric immunophenotyping of the bone marrow aspirate showed CD45− cells, which were CD19+ cytCD79a+ CD10+ CD81+ CD38+ HLA-DR+ CD22+ CD20− consistent with B-cell acute lymphoblastic leukemia (B-ALL). The extended immunostaining panel on bone marrow biopsy also showed positivity for cytCD79a, CD10, CD19, and BCL-2, whereas fluorescent in-situ hybridization for EWSR1 gene rearrangement was negative. Thus, a final diagnosis of CD45− FLI1+ MIC2+ B-ALL was established. Rare cases of CD45− B-ALL with immunoreactivity for MIC2 and Friend leukemia virus integration 1 (FLI1) have posed a diagnostic challenge for PSRCTs in the recent past. This case report highlights the role of multimodality approach in establishing a correct diagnosis in CD45− PSRCTs to ensure definitive therapy and better clinical outcome.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):614-617
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_520_18
      Issue No: Vol. 62, No. 4 (2019)
       
  • Invasive, gangrenous mucormycosis of arm: A fatal opportunistic infection
           in a highly immunocompromised host

    • Authors: Vijayanth Kanagaraju, Venkatesh Kumar Narayanasamy, Sanjeev Sukumaran, Udaya Moorthy, V Shyam Sundar, S Vidhya Lakshmi
      Pages: 618 - 620
      Abstract: Vijayanth Kanagaraju, Venkatesh Kumar Narayanasamy, Sanjeev Sukumaran, Udaya Moorthy, V Shyam Sundar, S Vidhya Lakshmi
      Indian Journal of Pathology and Microbiology 2019 62(4):618-620
      Opportunistic fungal infections occur predominantly in immunocompromised (IC) patients. Mucormycosis has the highest mortality among fungal infections. The organism is ubiquitous in its presence. The infection is commonly acquired by inhalation of fungal spores or by inoculation by direct trauma. Rhinocerebral and pulmonary mucormycosis present commonly with high mortality rates. Cutaneous mucormycosis (CM) is rarely reported and usually presents in two forms, superficial and disseminated. The superficial infection occurs commonly in immunocompetent hosts, and it can sometimes turn angioinvasive and become a fatal and very aggressive disseminated disease, especially in IC hosts. Coexistant risk factors increase the mortality rate. We report a case of posttraumatic, highly lethal, angioinvasive, and gangrenous type of CM of the arm in an IC patient. Diabetic ketoacidosis and cirrhosis due to chronic alcoholic liver disease were the risk factors.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):618-620
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_854_15
      Issue No: Vol. 62, No. 4 (2019)
       
  • A case report of Nocardia cyriacigeorgica presenting as cellulitis with
           multiple discharging sinuses

    • Authors: Archana Bora, Laxmi Rathore, Prabhat K Khatri, CS Chattopadhyay
      Pages: 621 - 623
      Abstract: Archana Bora, Laxmi Rathore, Prabhat K Khatri, CS Chattopadhyay
      Indian Journal of Pathology and Microbiology 2019 62(4):621-623
      Nocardia spp. are filamentous Gram positive bacteria that are ubiquitous soil saprophytes. The majority of nocardial infections occur in severely immunocompromised patients who are particularly susceptible to pulmonary disease and dissemination. Extrapulmonary nocardiosis is relatively common and can occur through hematogenous dissemination or a contiguous spread of necrotizing pneumonitis. Primary cutaneous and soft tissue nocardiosis can result from traumatic injury to the skin that involves contamination with soil. After skin inoculation, a superficial abscess or localized cellulitis can develop. Co-trimoxazole is the drug of choice for all types of nocardiosis. We are reporting a case of Nocardia cyriacigeorgica presenting as cellulitis followed tooth extraction.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):621-623
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_714_18
      Issue No: Vol. 62, No. 4 (2019)
       
  • Solid pseudopapillary neoplasm of pancreas metastasizing to spleen in a
           post menopausal female

    • Authors: Tanisha Singla, Charanjeet Ahluwalia, Gaurav Singla, Sachin Kolte, Swati Singla, Rashmi Arora
      Pages: 624 - 626
      Abstract: Tanisha Singla, Charanjeet Ahluwalia, Gaurav Singla, Sachin Kolte, Swati Singla, Rashmi Arora
      Indian Journal of Pathology and Microbiology 2019 62(4):624-626

      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):624-626
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_43_19
      Issue No: Vol. 62, No. 4 (2019)
       
  • Incidentally detected acalculous tubercular cholecystitis: A rare case
           report with a comprehensive review of literature

    • Authors: Dimple Chaudhary, Navpreet Kaur, Shramana Mandal, Nita Khurana, CB Singh
      Pages: 627 - 628
      Abstract: Dimple Chaudhary, Navpreet Kaur, Shramana Mandal, Nita Khurana, CB Singh
      Indian Journal of Pathology and Microbiology 2019 62(4):627-628

      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):627-628
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_107_19
      Issue No: Vol. 62, No. 4 (2019)
       
  • Primary actinomycosis of anterior abdominal wall: A rare occurrence,
           diagnosed on fine needle aspiration cytology

    • Authors: Mona Agnihotri, Kanchan Kothari, Leena Naik
      Pages: 629 - 630
      Abstract: Mona Agnihotri, Kanchan Kothari, Leena Naik
      Indian Journal of Pathology and Microbiology 2019 62(4):629-630
      Actinomycosis, a chronic suppurative and granulomatous infection, is caused by Actinomyces israeli. The common clinical presentations are cervicofacial, abdominal, and thoracic regions. Abdominal wall actinomycosis following pelvic or intraperitoneal involvement is known, but isolated abdominal wall involvement is extremely rare and can mimic malignancy. We report a case of primary actinomycosis of anterior abdominal wall, diagnosed on fine needle aspiration cytology (FNAC). Identifying fluffy colonies and branching swirling filaments positive for fungal and Gram stain on cytology smears aid correct diagnosis. FNAC is an effective and reliable tool for early diagnosis of actinomycosis. The treatment is centered around antibiotics, and thus it is essential to diagnose accurately and avoid unnecessary surgery.
      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):629-630
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_193_18
      Issue No: Vol. 62, No. 4 (2019)
       
  • Cavernous hemangioma of uvula: A rare site

    • Authors: Sharada Rane, Mayur V Parkhi, Gourav Agrawal, Ashwini Ghodke
      Pages: 631 - 632
      Abstract: Sharada Rane, Mayur V Parkhi, Gourav Agrawal, Ashwini Ghodke
      Indian Journal of Pathology and Microbiology 2019 62(4):631-632

      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):631-632
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_435_18
      Issue No: Vol. 62, No. 4 (2019)
       
  • EBV positive mucocutaneous ulcer of palate: A mimicker of malignancy

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      Pages: 632 - 634
      Abstract: Deepa Goel, Mandeep Singh
      Indian Journal of Pathology and Microbiology 2019 62(4):632-634

      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):632-634
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_51_19
      Issue No: Vol. 62, No. 4 (2019)
       
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      Pages: 635 - 636
      Abstract: Divya Basa, Pasyanthi Balijepalli, Kaustubh Mulay
      Indian Journal of Pathology and Microbiology 2019 62(4):635-636

      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):635-636
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_103_19
      Issue No: Vol. 62, No. 4 (2019)
       
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      Pages: 636 - 638
      Abstract: Ting Wang, Meng Cui, Asmitananda Thakur
      Indian Journal of Pathology and Microbiology 2019 62(4):636-638

      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):636-638
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_538_18
      Issue No: Vol. 62, No. 4 (2019)
       
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    • Authors: Arvind Ahuja, Vishal Sharma, Minakshi Bhardwaj, Sadhna Marwah, Sandeep Lamoria
      Pages: 638 - 640
      Abstract: Arvind Ahuja, Vishal Sharma, Minakshi Bhardwaj, Sadhna Marwah, Sandeep Lamoria
      Indian Journal of Pathology and Microbiology 2019 62(4):638-640

      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):638-640
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_630_18
      Issue No: Vol. 62, No. 4 (2019)
       
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    • Authors: Nouha Mahmood Alwani, Sohaila Fatima, Balkur Krishnamoorthi Adiga, Nazima Haider
      Pages: 641 - 642
      Abstract: Nouha Mahmood Alwani, Sohaila Fatima, Balkur Krishnamoorthi Adiga, Nazima Haider
      Indian Journal of Pathology and Microbiology 2019 62(4):641-642

      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):641-642
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_636_18
      Issue No: Vol. 62, No. 4 (2019)
       
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    • Authors: Priyanka Maity Chaudhuri, Nelofar Islam, Mou Das, Uttara Chatterjee, Chhanda Datta
      Pages: 643 - 645
      Abstract: Priyanka Maity Chaudhuri, Nelofar Islam, Mou Das, Uttara Chatterjee, Chhanda Datta
      Indian Journal of Pathology and Microbiology 2019 62(4):643-645

      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):643-645
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_510_18
      Issue No: Vol. 62, No. 4 (2019)
       
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    • Authors: Kavita Gaur, Vandana Puri, Manjula Jain, Sunaina Hooda, Sunita Sharma, Manoj Andley
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      Abstract: Kavita Gaur, Vandana Puri, Manjula Jain, Sunaina Hooda, Sunita Sharma, Manoj Andley
      Indian Journal of Pathology and Microbiology 2019 62(4):645-646

      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):645-646
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_246_18
      Issue No: Vol. 62, No. 4 (2019)
       
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    • Authors: Bharat Rekhi
      Pages: 647 - 649
      Abstract: Bharat Rekhi
      Indian Journal of Pathology and Microbiology 2019 62(4):647-649

      Citation: Indian Journal of Pathology and Microbiology 2019 62(4):647-649
      PubDate: Mon,14 Oct 2019
      DOI: 10.4103/IJPM.IJPM_690_19
      Issue No: Vol. 62, No. 4 (2019)
       
 
 
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