Publisher: Medknow Publishers   (Total: 427 journals)

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Showing 1 - 200 of 427 Journals sorted alphabetically
Acta Medica Intl.     Open Access   (SJR: 0.101, CiteScore: 0)
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advanced Biomedical Research     Open Access  
Advances in Human Biology     Open Access   (Followers: 5)
Advances in Skeletal Muscle Function Assessment     Open Access  
African J. for Infertility and Assisted Conception     Open Access   (Followers: 1)
African J. of Medical and Health Sciences     Open Access   (Followers: 3)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.25, CiteScore: 1)
African J. of Trauma     Open Access   (Followers: 1)
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 2)
Al-Azhar Assiut Medical J.     Open Access   (Followers: 2)
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Alexandria J. of Pediatrics     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 5)
Anesthesia : Essays and Researches     Open Access   (Followers: 10)
Annals of African Medicine     Open Access   (Followers: 2, SJR: 0.258, CiteScore: 1)
Annals of Bioanthropology     Open Access   (Followers: 5)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 15, SJR: 0.308, CiteScore: 1)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery     Open Access  
Annals of Indian Psychiatry     Open Access  
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 12, SJR: 0.352, CiteScore: 1)
Annals of Saudi Medicine     Open Access   (SJR: 0.238, CiteScore: 1)
Annals of Thoracic Medicine     Open Access   (Followers: 6, SJR: 0.524, CiteScore: 1)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 14, SJR: 0.152, CiteScore: 0)
Annals of Tropical Pathology     Open Access  
Apollo Medicine     Open Access  
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access   (Followers: 1)
Archives of Cardiovascular Imaging     Open Access   (Followers: 2, SJR: 0.187, CiteScore: 0)
Archives of Intl. Surgery     Open Access   (Followers: 10, SJR: 0.302, CiteScore: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 5)
Archives of Medicine and Surgery     Open Access   (Followers: 1)
Archives of Pharmacy Practice     Open Access   (Followers: 12, SJR: 0.102, CiteScore: 0)
Archives of Trauma Research     Open Access   (Followers: 4, SJR: 0.37, CiteScore: 2)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access   (Followers: 1)
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 5)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.856, CiteScore: 2)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 2)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.35, CiteScore: 1)
Asian Pacific J. of Reproduction     Open Access   (SJR: 0.227, CiteScore: 1)
Asian Pacific J. of Tropical Biomedicine     Open Access   (Followers: 2, SJR: 0.491, CiteScore: 2)
Asian Pacific J. of Tropical Medicine     Open Access   (Followers: 1, SJR: 0.561, CiteScore: 2)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
Biomedical and Biotechnology Research J.     Open Access   (Followers: 1)
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access   (Followers: 1)
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 2)
Canadian J. of Rural Medicine     Full-text available via subscription   (Followers: 1, SJR: 0.202, CiteScore: 0)
Cancer Translational Medicine     Open Access   (Followers: 2)
Cardiology Plus     Open Access   (Followers: 1)
Chinese Medical J.     Open Access   (Followers: 10, SJR: 0.52, CiteScore: 1)
CHRISMED J. of Health and Research     Open Access   (Followers: 2)
Clinical Cancer Investigation J.     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 5)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access   (Followers: 2)
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 10, SJR: 0.811, CiteScore: 2)
Contemporary Clinical Dentistry     Open Access   (Followers: 5, SJR: 0.353, CiteScore: 1)
Current Medical Issues     Open Access   (Followers: 2)
CytoJ.     Open Access   (Followers: 3, SJR: 0.543, CiteScore: 1)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 5, SJR: 0.152, CiteScore: 0)
Dental Research J.     Open Access   (Followers: 14, SJR: 0.416, CiteScore: 1)
Dentistry and Medical Research     Open Access   (Followers: 1)
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 8, SJR: 0.242, CiteScore: 0)
Education in the Health Professions     Open Access   (Followers: 2)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1, SJR: 1.799, CiteScore: 2)
Egyptian J. of Chest Diseases and Tuberculosis     Open Access   (Followers: 3, SJR: 0.155, CiteScore: 0)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 1)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Nursing J.     Open Access  
Egyptian Orthopaedic J.     Open Access   (Followers: 2)
Egyptian Pharmaceutical J.     Open Access   (Followers: 3)
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access   (Followers: 2)
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.822, CiteScore: 2)
Environmental Disease     Open Access   (Followers: 4)
Eurasian J. of Pulmonology     Open Access  
European J. of Dentistry     Open Access   (Followers: 4, SJR: 0.749, CiteScore: 2)
European J. of General Dentistry     Open Access   (Followers: 2, SJR: 0.12, CiteScore: 0)
European J. of Prosthodontics     Open Access   (Followers: 4)
European J. of Psychology and Educational Studies     Open Access   (Followers: 11, SJR: 0.113, CiteScore: 0)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.112, CiteScore: 0)
Genome Integrity     Open Access   (Followers: 2, SJR: 0.153, CiteScore: 0)
Glioma     Open Access  
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Gynecology and Minimally Invasive Therapy     Open Access   (SJR: 0.311, CiteScore: 1)
Hamdan Medical J.     Open Access  
Heart and Mind     Open Access  
Heart India     Open Access   (Followers: 2)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
Ibnosina J. of Medicine and Biomedical Sciences     Open Access   (Followers: 1)
IJS Short Reports     Open Access  
Imam J. of Applied Sciences     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.478, CiteScore: 1)
Indian J. of Burns     Open Access   (Followers: 3)
Indian J. of Cancer     Open Access   (Followers: 1, SJR: 0.361, CiteScore: 1)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.37, CiteScore: 1)
Indian J. of Dental Research     Open Access   (Followers: 5, SJR: 0.266, CiteScore: 1)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.468, CiteScore: 1)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 4, SJR: 0.445, CiteScore: 1)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1, SJR: 0.791, CiteScore: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4, SJR: 0.568, CiteScore: 1)
Indian J. of Health Sciences and Biomedical Research KLEU     Open Access   (Followers: 3)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.425, CiteScore: 1)
Indian J. of Medical Microbiology     Open Access   (Followers: 2, SJR: 0.503, CiteScore: 1)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.656, CiteScore: 1)
Indian J. of Medical Sciences     Open Access   (Followers: 3, SJR: 0.102, CiteScore: 0)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.347, CiteScore: 1)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.23, CiteScore: 0)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 3, SJR: 0.225, CiteScore: 1)
Indian J. of Ophthalmology     Open Access   (Followers: 5, SJR: 0.498, CiteScore: 1)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 8, SJR: 0.392, CiteScore: 1)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.199, CiteScore: 0)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 2)
Indian J. of Palliative Care     Open Access   (Followers: 8, SJR: 0.454, CiteScore: 1)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 4, SJR: 0.276, CiteScore: 1)
Indian J. of Pharmacology     Open Access   (SJR: 0.412, CiteScore: 1)
Indian J. of Psychiatry     Open Access   (Followers: 2, SJR: 0.408, CiteScore: 1)
Indian J. of Psychological Medicine     Open Access   (SJR: 0.368, CiteScore: 1)
Indian J. of Public Health     Open Access   (Followers: 1)
Indian J. of Radiology and Imaging     Open Access   (Followers: 5)
Indian J. of Research in Homoeopathy     Open Access   (Followers: 2)
Indian J. of Respiratory Care     Open Access   (Followers: 3)
Indian J. of Rheumatology     Open Access   (Followers: 1, SJR: 0.119, CiteScore: 0)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.34, CiteScore: 0)
Indian J. of Social Psychiatry     Open Access   (Followers: 1)
Indian J. of Transplantation     Open Access  
Indian J. of Urology     Open Access   (Followers: 5, SJR: 0.434, CiteScore: 1)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Indian Spine J.     Open Access  
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intervention     Open Access   (Followers: 2)
Intl. Archives of Health Sciences     Open Access  
Intl. J. of Abdominal Wall and Hernia Surgery     Open Access   (Followers: 1)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Clinicopathological Correlation     Open Access   (Followers: 1)
Intl. J. of Community Dentistry     Open Access  
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1, SJR: 0.192, CiteScore: 0)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 8, SJR: 0.142, CiteScore: 0)
Intl. J. of Growth Factors and Stem Cells in Dentistry     Open Access  
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 6)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.535, CiteScore: 1)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4, SJR: 0.17, CiteScore: 0)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 3)
Intl. J. of Orofacial Biology     Open Access   (Followers: 1)
Intl. J. of Orofacial Research     Open Access   (Followers: 2)
Intl. J. of Orthodontic Rehabilitation     Open Access   (Followers: 2)
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 2)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.623, CiteScore: 1)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 5, SJR: 0.653, CiteScore: 1)
Intl. J. of the Cardiovascular Academy     Open Access   (SJR: 0.105, CiteScore: 0)
Intl. J. of Trichology     Open Access   (SJR: 0.4, CiteScore: 1)
Intl. J. of Yoga     Open Access   (Followers: 16)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 7)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 3)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  

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Similar Journals
Journal Cover
Indian Journal of Pathology and Microbiology
Journal Prestige (SJR): 0.276
Citation Impact (citeScore): 1
Number of Followers: 4  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0377-4929 - ISSN (Online) 0974-5130
Published by Medknow Publishers Homepage  [427 journals]
  • From Editor's desk

    • Authors: Ranjan Agrawal
      Pages: 169 - 170
      Abstract: Ranjan Agrawal
      Indian Journal of Pathology and Microbiology 2020 63(2):169-170

      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):169-170
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/0377-4929.282723
      Issue No: Vol. 63, No. 2 (2020)
       
  • COVID-19 and lung pathology

    • Authors: Amita Jain
      Pages: 171 - 172
      Abstract: Amita Jain
      Indian Journal of Pathology and Microbiology 2020 63(2):171-172

      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):171-172
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_280_20
      Issue No: Vol. 63, No. 2 (2020)
       
  • Why is SARS-CoV-2 testing not possible in every medical laboratory?

    • Authors: Prashant Gupta
      Pages: 173 - 174
      Abstract: Prashant Gupta
      Indian Journal of Pathology and Microbiology 2020 63(2):173-174

      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):173-174
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/0377-4929.282722
      Issue No: Vol. 63, No. 2 (2020)
       
  • Plagiarism

    • Authors: Ranjan Agrawal
      Pages: 175 - 176
      Abstract: Ranjan Agrawal
      Indian Journal of Pathology and Microbiology 2020 63(2):175-176

      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):175-176
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/0377-4929.282724
      Issue No: Vol. 63, No. 2 (2020)
       
  • Clear cell lesions in pathology: Histomorphologic approach to diagnosis

    • Authors: Asaranti Kar, Kaumudee Pattnaik, Tushar Kar, Priyadarshini Biswal, Chandraprava Mishra, Lilabati Guru
      Pages: 177 - 187
      Abstract: Asaranti Kar, Kaumudee Pattnaik, Tushar Kar, Priyadarshini Biswal, Chandraprava Mishra, Lilabati Guru
      Indian Journal of Pathology and Microbiology 2020 63(2):177-187
      There has been remarkable progress in the field of surgical pathology; however, histomorphology has remained the most important and essential tool of the surgical pathologist in everyday practice till now. It is surprising that the hematoxylin–eosin (H and E) stain, introduced more than a century ago, has still remained the gold standard stain for histological examination and diagnosis of human diseases. Besides different findings or clues observed in histopathology sections like inclusions, granules, grooving, globules, halo, or clearing, which would enable the pathologist to provide a precise and accurate diagnosis; observation of clear cells is one of the important findings and clue for reporting. It may also sometimes lead to difficulties and delays in establishing the diagnosis. It can be focal or extensive and primary or rarely it may be secondary. Clear cell changes may be observed in many non-neoplastic, benign, or malignant tumors of diverse origin. Clear cell tumors contain a preponderance of clear cells. It can be seen in almost all the organs of human body and can be classified according to location or biological behavior. Commonly seen clear-cell tumors are usually malignant and common organs involved are female genital tract, urogenital tract, head and neck areas, central nervous system, skin, and rarely in bone and soft tissues. For approach to clear cell lesions, one has to decide if the change is artifactual, a mimic of clear cell tumors, or a clear cell tumor in reality. Once the mimics and artifactual/degenerative changes have been ruled out, a tumor either primarily of clear cell origin or showing secondary change has to be decided. The tumor next is to be diagnosed as benign/malignant and epithelial/mesenchymal based on morphology.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):177-187
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_791_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • A comparison between unifocal papillary thyroid microcarcinoma with
           noninvasive follicular thyroid neoplasm with papillary-like nuclear
           features and other patterns: A retrospective clinicopathological study

    • Authors: Emel Cakir, Ismail Saygin, Savas Kisioglu
      Pages: 188 - 193
      Abstract: Emel Cakir, Ismail Saygin, Savas Kisioglu
      Indian Journal of Pathology and Microbiology 2020 63(2):188-193
      Background: Papillary thyroid microcarcinoma (mPTC) is defined as a tumor with low malignancy potential. Different treatment protocols have been used at different centers for analyzing this tumor which has common recurrence and metastasis rates. Consequently, in 2016, the definition of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was accepted which included the lesions > cm. It is important to explain the clinical course and appropriate treatment options for mPTC and its subtypes. Aims: In this study, we aimed to describe the clinical course of mPTC with and without NIFTP and to determine different risk groups among these subtypes. Material and Methods: We performed microscopic reexamination of about 280 unifocal mPTCs retrieved from our archives between 2007–2018 and analyzed the results of morphological and clinical comparison among these cases that had 0–11-years of clinical follow-up. Results: Among 280 unifocal mPTCs, 127 cases (45.4%) had classical morphology, 58 (20.7%) had NIFTP, 53 (18.9%) had infiltrative pattern, 27 (9.6%) had oncocytic pattern, 12 (4.3%) showed capsular invasion, and 3 (1.1%) showed other morphologies. Seven patients were detected with lymph node metastasis and one with distant metastasis at diagnosis. Lymph node metastasis (recurrence) was postoperatively detected in five patients. All patients with recurrence were women. Moreover, three of these patients were in their 30s and two in 70s. The median diameter of the tumor was 3 mm. Both invasive and noninvasive cases have recurred. Conclusion: Contrary to the results of the previous studies, the results of our study did not confirm the indolent course of mPTC with NIFTP. However, metastasis was detected both at the time of diagnosis and during the postoperative period. The malignancy potential of these tumors may not be low. Therefore, more clinicopathological and molecular studies are needed to determine the biological behavior of mPTC cases with different histology.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):188-193
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_586_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Dual-color dual-hapten in situ hybridization (D-DISH) – Comparison
           with fluorescence in situ hybridization (FISH) for HER2/neu testing in
           breast cancer

    • Authors: Pooja K Gajaria, Sonali Tambe, Trupti Pai, Asawari Patil, Sangeeta B Desai, Tanuja M Shet
      Pages: 194 - 199
      Abstract: Pooja K Gajaria, Sonali Tambe, Trupti Pai, Asawari Patil, Sangeeta B Desai, Tanuja M Shet
      Indian Journal of Pathology and Microbiology 2020 63(2):194-199
      Context: HER2/neu testing in breast cancer is a mandate due to availability of trastuzumab, a monoclonal antibody targeted against this biomarker. Dual-color dual-hapten in situ hybridization (D-DISH) is a new test for assessment of HER2/neu gene overexpression on light microscopy. Aims: This was a validation study for D-DISH in our laboratory and was conducted to study the concordance between fluorescence in situ hybridization (FISH) and D-DISH for HER2/neu testing in breast cancer. Materials and Methods: In all, 150 cases of invasive breast carcinoma requested for FISH analysis were selected. Immunohistochemistry by Ventana PATHWAY anti-HER2/neu (4B5) antibody, FISH by ZytoLight SPEC ERBB2/CEN17 Dual Color Probe, and D-DISH using the Ventana INFORM HER2 Dual ISH DNA Probe Cocktail Assay was carried out. Statistical Analysis: Cohen's kappa coefficient was used to calculate concordance between FISH and D-DISH assays. The ratios and average number of signals were compared with Lin's concordance correlation coefficient. Results: About 93.1% of the cases showed concordance between FISH and D-DISH results. Cohen's kappa correlation coefficient was 0.836, indicating almost perfect level of agreement. Lin's concordance correlation coefficient (ρc) showed moderate strength of agreement for HER2/chromosome 17 ratios between FISH and D-DISH assays (ρc 0.9452). As per the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) 2018 updated guidelines, four of the cases that were nonamplified on FISH showed low-level amplification on D-DISH due to counting errors caused by faint signals or background dust. Genomic heterogeneity and larger red chromosome 17 signals on D-DISH led to discordance of the six cases amplified by FISH. D-DISH failure rate was 3.33%. Conclusion: Overall, D-DISH showed good concordance with FISH but needs expertise for reporting.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):194-199
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_861_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Quantitative mast cell analysis and hormone receptor study (ER, PR and
           HER2/neu) in invasive carcinoma of breast

    • Authors: Rama D Pyla, RM Potekar, Vijayalaxmi S Patil, Anil K Reddy, KV Sathyashree
      Pages: 200 - 204
      Abstract: Rama D Pyla, RM Potekar, Vijayalaxmi S Patil, Anil K Reddy, KV Sathyashree
      Indian Journal of Pathology and Microbiology 2020 63(2):200-204
      Context: Breast cancer constitutes nearly one third of cancers among women. Immune responses caused by neoplastic cells lead to the accumulation of inflammatory cells like mast cells (MCs), macrophages, lymphocytes, and plasma cells around the tumor tissue forming the tumor microenvironment. Aim: The study aims at quantifying the role of MCs in different grades of invasive carcinoma of breast with respect to estrogen receptor (ER), progesterone receptor (PR), and Human Epidermal growth factor Receptor 2 (HER2/neu). Materials and Methods: This study included 60 cases of invasive carcinoma of breast. Toluidine blue staining was used for quantitative MC analysis and correlated with immunohistochemistry analysis for hormonal markers' positivity—ER, PR and HER2/neu. Results: The mean age was 52 years (range: 25–75 years). The average number of MCs in Grade I, II, and III were 24.05, 18.4, and 7.9, respectively, with a significant P value. ER, PR, and HER2/neu positivity was found in 60%, 55%, and 32% of the cases, respectively. ER positivity with mean MC count of 23.55 was found in 36 cases, and 33 cases were positive for PR with a mean MC count of 24.18 and a significant P value. HER2 positive cases were 28 with a mean MC count of 20.82. Conclusion: The presence of MCs in breast cancer is inversely proportional to the grade of tumor, i.e., a maximum number of MCs were seen in low grade tumors. In addition, there is a positive correlation between ER and PR receptor positivity with the presence of MCs in the stroma of breast cancer.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):200-204
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_155_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Microvessel density and vascular endothelial growth factor receptors in
           breast carcinoma under the influence of rapamycin and platelet factor 4

    • Authors: Muhammad Shahidan Muhammad Sakri, Wan Faiziah Wan Abdul Rahman, Tengku Ahmad Damitri Al-Astani Tengku Din, Fauziah Mohd Idris, Hasnan Jaafar
      Pages: 205 - 209
      Abstract: Muhammad Shahidan Muhammad Sakri, Wan Faiziah Wan Abdul Rahman, Tengku Ahmad Damitri Al-Astani Tengku Din, Fauziah Mohd Idris, Hasnan Jaafar
      Indian Journal of Pathology and Microbiology 2020 63(2):205-209
      Background: Vascular endothelial growth factor receptors (VEGFRs) are major endothelial growth factor receptors that influence the growth of a tumor. Microvessel density ( MVD) is the quantification method of various aspects of tumor vasculature that indicates angiogenic activity. This study aims to analyze the correlation between MVD to the expression of VEGFRs on breast cancer tissue. Materials and Method: A total of 60 N-methyl-N-nitrosourea (MNU)-induced breast carcinomas in rats were suppressed by using antiangiogenic drugs. The rats were then sacrificed, and the tumor was fixed in 10% formalin, paraffin embedded, and immunohistochemistry stained using VEGFRs and CD34. Result: One-way ANOVA test showed a significant difference in all markers that have been used (P < 0.05) on MNU-breast tumor treated with rapamycin (M= 90.1664, SD= 7.4487), PF4 (M= 93.7946, SD= 7.1303) and rapamycin + PF4 (M= 93.6990, SD= 1.8432). We obtained a significant reduction of MVD count on breast carcinoma for rapamycin group (M= 25.6786, SD= 9.7075) and rapamycin + PF4 group (M= 30.5250, SD= 13.6928) while PF4 group (M=47.7985, SD=4.8892) showed slightly increase compared to control (M= 45.1875, SD= 4.4786). There was a moderately strong, positive correlation between angiogenic markers; Flt-1 (r= 0.544, n=60, P < 0.005) and Flt-4 (r= 0.555, n= 60, P < 0.005) while Flk-1 (r= 0.797, n= 60, P < 0.005) showed a strong, positive correlation with MVD. Conclusion: MVD was strongly correlated to the VEGFRs expression on breast carcinoma.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):205-209
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_496_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Diagnosis of pulmonary tuberculosis from gastric aspirate samples in
           nonexpectorating pediatric patients in a tertiary care hospital

    • Authors: Shiwangi Sharma, Anuradha Shulania, Arvind Achra, Hishmi Jeram, Stuti Kansra, Nandini Duggal
      Pages: 210 - 213
      Abstract: Shiwangi Sharma, Anuradha Shulania, Arvind Achra, Hishmi Jeram, Stuti Kansra, Nandini Duggal
      Indian Journal of Pathology and Microbiology 2020 63(2):210-213
      Objectives: The aim of this study was to assess the utility of Xpert assay, Ziehl–Neelsen (ZN) staining, and Mycobacteria Growth Indicator Tube (MGIT™) culture for diagnosis of pediatric pulmonary tuberculosis from gastric aspirate (GA) samples and to compare Xpert assay and ZN staining with MGIT rapid liquid culture. Materials and Methods: GA samples from 210 nonexpectorating children, aged between 6 months to 12 years, presenting to the pediatric out-patient department (OPD) with clinical suspicion of tuberculosis (TB) were collected. The samples were tested by GeneXpert, ZN staining, and MGIT liquid culture. Results: GeneXpert is a more sensitive method for rapid and early diagnosis of pediatric TB when compared with microscopy.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):210-213
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_694_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • HER-2/neu over expression in gall bladder adenocarcinoma: A quest for
           potential therapeutic target

    • Authors: Pragya Jain, Surbhi Goyal, Geeta Chauhan, Kaushik Majumdar, Shahajad Ali, Puja Sakhuja, Anil K Agarwal
      Pages: 214 - 220
      Abstract: Pragya Jain, Surbhi Goyal, Geeta Chauhan, Kaushik Majumdar, Shahajad Ali, Puja Sakhuja, Anil K Agarwal
      Indian Journal of Pathology and Microbiology 2020 63(2):214-220
      Background: Gall bladder carcinoma (GBC) is an aggressive malignancy with high mortality and aggressive course, with palliation as the only available option. Objectives: To evaluate frequency of HER-2/neu overexpression in GBC and to seek its correlation, if any with conventional clinicopathological parameters and survival. Methods: Immunohistochemistry (IHC) was performed on 200 cases of GBC, 32 cases of dysplasia, and 100 cases of chronic cholecystitis. Fluorescent in situ hybridization (FISH) was performed on 30 randomly selected cases of GBC to validate IHC. HER-2/neu overexpression (IHC 3+/FISH amplification ≥2.2) was correlated with clinicopathological parameters by Chi-square test.P < 0.05 was considered significant. Survival analysis was done by log-rank test and Kaplan-Meier analysis. Results: HER-2/neu overexpression was seen in 14% (28/200) GBC cases but was not found in dysplasia and chronic cholecystitis. Majority of these cases were ≤grade 2 and in advanced stage, however this was not statistically significant. A lower mean survival in HER-2/neu positive group as compared to HER-2/neu negative group (17.1 ± 2.3 month versus 67.6 ± 8.5 month, respectively) was observed. Concordance between IHC and FISH was seen in 18/19 cases. Conclusion: This study delineates a subset of GBC patients with HER-2/neu overexpression, in whom targeted therapy can offer a survival benefit.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):214-220
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_664_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Loss of ASXL1 expression is associated with lymph node metastasis in
           colorectal cancer

    • Authors: Jun H Lee, Ju-Hee Lee, Byung K Ahn, Seung S Paik, Hyunsung Kim, Kang H Lee
      Pages: 221 - 225
      Abstract: Jun H Lee, Ju-Hee Lee, Byung K Ahn, Seung S Paik, Hyunsung Kim, Kang H Lee
      Indian Journal of Pathology and Microbiology 2020 63(2):221-225
      Context: The function of ASXL1 in colorectal cancer (CRC) has not been investigated yet. Aims: The purpose of this study was to investigate the clinicopathological and prognostic impact of ASXL1 expression on CRC. Settings and Design: The intensity of expression was scored as 0–3, and the extent of staining was scored as 0–4, based on the percentage of positive cells. The immunoreactivity score (IRS) was calculated by multiplying the two scores. Materials and Methods: We performed immunohistochemical staining of ASXL1 using tissue microarrays of 408 CRCs, 46 normal colonic mucosae, 48 adenomas, and 92 metastatic lymph nodes. Statistical Analysis Used: Clinicopathological variables were compared using Fisher's exact test, χ2-test, or unpaired Student's t-test, depending on the nature of the data. Results: A negative expression of ASXL1 was observed in 10.9% of normal mucosae, 27.1% of adenomas, 55.6% of adenocarcinomas, and 71.7% of metastatic lymph nodes (P < 0.001). With respect to the IRS cut-off score, lymph node metastasis and lymphatic invasion were more frequent in the IRS 0–6 group than in the IRS 8–12 group (56.3% vs. 33.3%, P = 0.034; 56.0% vs. 33.3%, P = 0.035). The 5-year disease-free survival rate was significantly lower in patients with IRS 0–6 group than those with IRS 8–12 group (78.7 ± 2.5 vs. 100%, P = 0.034). Conclusion: ASXL1 might act as a tumor suppressor in CRC. The loss of ASXL1 expression might be associated with lymph node metastasis and lymphatic invasion in CRC.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):221-225
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_822_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Anti-glomerular basement membrane disease: A clinicomorphological study of
           16 cases

    • Authors: Srinivasrao Vavilapalli, Nishika Madireddy, Megha S Uppin, Karthik Kalidindi, Swarnalatha Gudithi, Gangadhar Taduri, Sree Bhushan Raju
      Pages: 226 - 229
      Abstract: Srinivasrao Vavilapalli, Nishika Madireddy, Megha S Uppin, Karthik Kalidindi, Swarnalatha Gudithi, Gangadhar Taduri, Sree Bhushan Raju
      Indian Journal of Pathology and Microbiology 2020 63(2):226-229
      Introduction: Antiglomerular basement membrane disease manifests as rapidly progressive glomerulonephritis and alveolar hemorrhage. It encompasses 10–15% of crescentic glomerulonephritis and is associated with poor outcome. In this study, we have elaborated on the clinical details, morphological features, and outcome of anti-GBM glomerulonephritis. Materials and Methods: All the consecutive biopsy-proven cases of anti-GBM glomerulonephritis over a period of 4½ years were analyzed, retrospectively. Results: Sixteen cases were diagnosed as anti-GBM glomerulonephritis during the study period. Twelve patients presented with rapidly progressive renal failure of which four patients required hemodialysis at the time of presentation. Goodpasture's syndrome was noted in two patients. Thirteen cases were positive for circulating anti-GBM antibodies and two patients showed double positivity for both anti-GBM antibodies and ANCA. Fifteen biopsies revealed crescentic glomerulonephritis with linear deposition of IgG along the glomerular basement membrane in all the 16 cases. Conclusion: Renal biopsy analysis is important in the diagnosis of Anti GBM nephritis. Morphology is an important predictor of disease progression.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):226-229
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_712_18
      Issue No: Vol. 63, No. 2 (2020)
       
  • Immunohistochemical expression of interlukin10 (IL10) and heat shock
           protein-90 (HSP-90) in prostatic carcinoma

    • Authors: Wasan Abdul-ilah Bakir, Hiba Ahmed Gaidan, Methaq Mueen Al-kaabi
      Pages: 230 - 234
      Abstract: Wasan Abdul-ilah Bakir, Hiba Ahmed Gaidan, Methaq Mueen Al-kaabi
      Indian Journal of Pathology and Microbiology 2020 63(2):230-234
      Background: Specific cytokines are related to pathologically changed prostate, propose that the balance in cytokine differs in normal and pathological prostate. Of these cytokines the interleukins 10, due to its “pleiotropic” actions in inflammation and angiogenesis, and HSP-90 due to its expression in tumor cells at high levels, suggesting that it has an important role for growth and/or survival of tumor cells. Aims: Evaluation of HSP-90 and IL10 immunoreactivity in benign prostatic hyperplasia (BPH) and prostatic carcinoma and to correlate this expression with clinicopathological parameters. Settings and Design: A retrospective study in which 83 Paraffin-embedded tissue specimens including (43) BPH, (40) prostatic carcinoma and (20) normal prostate as control were included between the period of January 2015 and January 2017. Patients, Material and Methods: All the cases were evaluated histopathologically and stained immunohistochemically for IL10 and HSP-90. Only cytoplasmic staining was considered as positive. Immunoreactivity scoring for both markers expression was calculated based on both staining intensity and percentage. Statistical Analysis: Was done using SPSS Version 21 statistical analysis software. P value of <0.05 was considered statistically significant. Result: Statistical analysis of HSP-90 and IL10 expression revealed a highly significant correlation of expression of these two markers in advanced Gleason grading and tumor, node, and metastasis (TNM) staging cases of prostatic carcinoma. Conclusion: High expression of IL10 and HSP-90 is associated with high grade and stage of prostatic carcinoma. This provides a base for further studies and researches on the role of these investigated proteins as prognostic markers immunotherapy targets for carcinoma of the prostate.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):230-234
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_460_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Expression of p53 in epithelial ovarian tumors

    • Authors: Nihad Abdul Razak Amanullah, Usha Poothiode, Letha Vilasiniamma
      Pages: 235 - 240
      Abstract: Nihad Abdul Razak Amanullah, Usha Poothiode, Letha Vilasiniamma
      Indian Journal of Pathology and Microbiology 2020 63(2):235-240
      Background: Ovarian cancers remain the most lethal of all gynecological malignancies despite major developments in their treatment. Objectives: To study the rate of expression and staining patterns of p53 in various histological types and grades of epithelial ovarian tumors (EOT). Materials and Methods: Sixty EOTs received in a tertiary care center were studied for gross, microscopy, and p53 immunohistochemistry (IHC) expression patterns. Parameters such as age, laterality of tumor, ascites, capsule rupture, tumor size, stage at presentation, metastasis, tumor grade, and number of mitosis were correlated. Results: Of the sixty cases studied, 23 (38.3%) were malignant. Serous carcinomas were the largest group with 17 cases (74%) followed by mucinous with 4 cases (17%) and 2 clear cell carcinomas (9%). All benign and borderline EOT were p53 negative. 65.2% of the malignancies were p53 positive and all of them were serous malignancies. 15 out of 16 high-grade serous carcinomas were p53 positive (94%), while one case was negative (6%). 10 cases (63%) showed intense diffuse positivity of more than 60% of the nucleus, while 5 cases (31%) showed aberrant null staining <5% staining of the nucleus. All mucinous, clear cell carcinomas, and the only low-grade serous carcinoma in the study were p53 negative. P53 staining had positive correlations with variables like capsule rupture, ascites, laterality, and CA 125. Conclusions: The study highlights the different rates of expression and staining patterns of p53 and the need for correct interpretation of p53 IHC for the diagnosis of various EOT.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):235-240
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_526_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Frequency and clinical significance of red cell antibodies in pregnancy
           – A prospective study from India

    • Authors: Soumya Das, Shamee Shastry, Lavanya Rai, Poornima B Baliga
      Pages: 241 - 246
      Abstract: Soumya Das, Shamee Shastry, Lavanya Rai, Poornima B Baliga
      Indian Journal of Pathology and Microbiology 2020 63(2):241-246
      Background: For appropriate management of hemolytic disease of the fetus and newborn (HDFN), it is important to detect irregular red cell antibody in the antenatal period. Though it is a simple one-step method, it is not part of routine antenatal screening in many developing countries. To reiterate the importance of antenatal antibody screening, we have assessed the frequency and clinical significance of irregular red cell antibodies in our patient population. Materials and Methods: A prospective study was carried out from October 2013 to May 2015 at a tertiary care center from south India. All antenatal samples received by the laboratory for red cell antibody screening were screened using a commercial three-cell screening panel. Antibody identification along with further Immunohematological techniques as required were performed for cases with positive screening results. Neonates of the alloimmunized cases were followed up to determine the clinical significance of the antibody. Results: A total of 2336 antenatal mothers were screened for red cell antibodies. The overall rate of alloimmunization in the study group was 2.27%. Alloimmunization rate among RhD-negative pregnancies was 6.9%. Other than anti-D (49%), we identified anti-D + anti-C (5%), anti-G (5%), anti-c (5%), anti-E (2%), anti-e (2%), anti-H (Bombay phenotype) (7%), anti-M (2%), anti-Lea (2%), anti-Leb (12%), and autoantibodies (9%) in the maternal serum. Anti-D, anti-D + anti-C, anti-G, anti-c, and anti-H were found to be clinically significant in this study. Conclusion: This study showed that 1 in 125 RhD-positive pregnancies can develop red cell alloantibodies. Hence, implementing routine antenatal antibody screening irrespective of RhD status is essential.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):241-246
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_737_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Comparative analysis of “APTT vs RVVT” based activated protein
           C resistance assay in the diagnosis of Factor V Leiden mutation

    • Authors: Mirza Asif Baig
      Pages: 247 - 250
      Abstract: Mirza Asif Baig
      Indian Journal of Pathology and Microbiology 2020 63(2):247-250
      Background: Thrombophilia is a hypercoagulable state characterized by increased venous thrombosis. The most common cause of heritable thrombophilia is Factor V Leiden (FVR506Q) homozygous state, with a relative risk of 10–80 times as compared to normal individuals and Lupus anticoagulant is the most common cause of acquired thrombophilia. The main objective of this study is to compare the sensitivity of activated partial thromboplastin time (APTT) vs dilute Russell viper venom test (DRVVT) based APCR assays with predilution in Factor V-deficient plasma for diagnosis of Factor V Leiden mutation. Materials And Methods: The coagulometer used for APCR test was Sysmex CS-5100. APTT reagent used is Pathrombin SL supplied by Siemens. All data were expressed as mean ± SD. Statistical analysis was done using unpaired students t-test and a P value <0.05 was considered as statistical significance. Results: A total of 300 cases of APCR (200 cases of Factor V Leiden mutation was confirmed by PCR and 100 acquired) were studied. The sensitivity of screening APTT-based APCR for detection of Factor V Leiden mutation is 67% and for the noncarrier state, it is 62%. The sensitivity of modified APTT and DRVVT with predilution in FV-deficient plasma for detection of Factor V Leiden mutation is 82% and 84%, respectively and for acquired causes, it is 48% and 86%, respectivelyConclusion: Screening APTT test has increased in activated protein C resistance (APCR) due to Factor V Leiden mutation as well as acquired causes such as patients on direct-acting oral anticoagulants, warfarin, lupus anticoagulants, and oral contraceptive pills which are independent risk factors of venous thrombosis. Modified DRVVT with predilution in FV-deficient plasma is more sensitive than screening and modified APTT-based APCR test in the diagnosis of Factor V Leiden mutation and the former test can distinguish homozygous and heterozygous states from normal individuals.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):247-250
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_899_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Management of transfusion needs in a case of immunizing anti-M antibody in
           a patient with acute myeloid leukemia

    • Authors: Anisha Navkudkar, Priti Desai, Rajesh Thakkar, Sunil Rajadhyaksha
      Pages: 251 - 254
      Abstract: Anisha Navkudkar, Priti Desai, Rajesh Thakkar, Sunil Rajadhyaksha
      Indian Journal of Pathology and Microbiology 2020 63(2):251-254
      Anti-M is a relatively common “naturally occurring” antibody. Unexpected alloantibodies in patient's serum other than ABO isoagglutinins (e.g., anti-M) may cause a discrepancy in the reverse grouping. As long as anti-M does not react at 37°C, it is clinically insignificant for transfusion. However, we found this antibody to be of “immunizing” type which was reactive at 37°C and AHG phase and showing problems in blood grouping and crossmatch. This antibody had both IgM and IgG components. When “M” antibodies active at 37°C are encountered, antigen-negative or red cells that are compatible with an indirect antiglobulin test should be provided.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):251-254
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_166_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Utility of grey zone testing strategy in transfusion transmissible
           infection testing in blood bank is of limited value!

    • Authors: Gunjan Bhardwaj, Aseem K Tiwari, Dinesh Arora, Geet Aggarwal, Swati Pabbi, Divya Setya
      Pages: 255 - 257
      Abstract: Gunjan Bhardwaj, Aseem K Tiwari, Dinesh Arora, Geet Aggarwal, Swati Pabbi, Divya Setya
      Indian Journal of Pathology and Microbiology 2020 63(2):255-257
      Several blood banks use grey zone (GZ) phenomenon (defined as samples with optical density within 10% below the cut off in enzyme immuno-assay [EIA]/chemiluminescence immunoassay [CLIA]) to further augment blood safety. There is paucity of data regarding usefulness of GZ sample and its application in Transfusion Transmissible Infection (TTI) screening procedures in blood transfusion services. We looked at our GZ sample results and their confirmatory test results to verify if it adds to blood safety in our set-up? We performed a prospective analytical study on blood donors' samples over two years. All the donors' samples were screened for TTI using CLIA. Samples with signal/cut-off ratio between ≥0.90 and <1.00 were classified under GZ. They were re-tested in duplicate and submitted to confirmatory testing: Neutralization Test for HBsAg, Immunoblot for HCV, and Western blot for HIV. Among the 50,064 blood donors donating the blood during study period, 573 (1.14%) donors were reactive for HBsAg, HCV, and HIV. Forty-seven (0.1%) TTI samples were GZ, but none was “confirmed positive.” The utility of GZ testing seems to be limited. However, this may be continued for sake of “erring on the side of caution” and since this only results in negligible wastage (0.1%) of blood units.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):255-257
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_404_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Development and applicability of a smartphone torch based emergency light
           source for microscopy

    • Authors: Himel Mondal, Shaikat Mondal, Debasish Das
      Pages: 258 - 261
      Abstract: Himel Mondal, Shaikat Mondal, Debasish Das
      Indian Journal of Pathology and Microbiology 2020 63(2):258-261
      Background: Modern microscopes are equipped with built-in illuminator. However, during a power outage, microscopy is not possible with extra mirror system if an alternative light source is not available. Smartphone torch can serve as a light source. Holding it under the microscope is difficult when both hands are engaged in microscopy. Aim: The aim of the study was to develop a stand for smartphone torch and to check the applicability of smartphone torch-based light source in microscopy. Materials and Methods: A stand was made with cardboard for keeping the smartphone on it. An optical diffuser was made with white polyethylene plastic. Smartphone with the stand and optical diffuser can serve as a soft light source. A convenient sample of 16 faculty member rated 11 slides first under the microscope with its built-in light source and then twice with the new device as a light source on 10-point Likert type scale. Applicability of the device was checked by validity and reliability by Intraclass Correlation Coefficients (ICC) with α = 0.05. Results: The raters were able to examine the slides under the microscope with the new devices as a light source. An overall score (11 slides, 16 observers) for the image quality was 9.36 ± 0.86 (range 6-10). Interrater, intrarater, and test-retest ICC were 0.939 (P < 0.001), 0.853 (P = 0.003), and 0.889 (P < 0.001) respectively which indicate “good” to “excellent” level of reliability. Conclusion: Developed smartphone torch stand with an optical diffuser can serve as an emergency light source in microscopy. This may be a useful tool for settings with a frequent power outage.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):258-261
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_263_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Cerebral hemispheric glioblastoma with PNET-like morphology and histone
           H3.3 G34 mutation in younger patients: Report of three rare cases and
           diagnostic pitfalls

    • Authors: Yuanyuan Cheng, Weiqi Bao, Qian Wu
      Pages: 262 - 266
      Abstract: Yuanyuan Cheng, Weiqi Bao, Qian Wu
      Indian Journal of Pathology and Microbiology 2020 63(2):262-266
      Recurrent mutations in H3F3A that encodes the histone 3 variant H3.3, lead to amino acid substitutions including K27M and G34R/V-which are observed in high-grade gliomas (HGGs) of children and young adults. Previous studies have focused on gliomas with K27M mutation, whereas gliomas with G34R/V mutation have received little attention. Herein, we report three rare cases of glioblastoma (GBM) with H3.3 G34 mutation arising from a cerebral hemisphere in two children and one young adult. All three cases showed microscopic characteristics of central nervous system primitive neuroectodermal tumor (CNS-PNET, called CNS embryonal tumors in WHO 2016 Revised 4th Edition) and presented H3.3 G34 mutation. H3.3 G34-mutant brain tumors were formerly a group of histopathologically distinct neoplasms, involved in GBM, CNS-PNET, and astroblastoma. However, recent studies have demonstrated that different CNS tumors with H3.3 G34 mutation display coherent epigenetic signatures, implying a single biological origin. Correspondingly, our three cases showed high consistency in tumor location, histological morphology, and molecular phenotype. Their immunophenotypes are similar to astrocytoma, with ATRX loss and TP53 mutation. Therefore it suggests that these H3.3 G34-mutant brain tumors may be a rare entity of HGG.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):262-266
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_544_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Myxoid meningioma: A case report of an extremely rare subtype of
           metaplastic meningioma

    • Authors: Seema Rahar, Arvind Ahuja, Purnima Bharati, Minakshi Bhardwaj, Ajay Chaudhary
      Pages: 267 - 269
      Abstract: Seema Rahar, Arvind Ahuja, Purnima Bharati, Minakshi Bhardwaj, Ajay Chaudhary
      Indian Journal of Pathology and Microbiology 2020 63(2):267-269
      Myxoid meningioma is a rare histological variant of meningiomas grouped into the subtype of metaplastic meningiomas (World Health Organization grade I) characterized by the presence of myxoid areas and meningothelial cells along with unique ultrastructural features that help distinguish it from other meningiomas. Hereby, we report a case of a myxoid meningioma in a 40-year-old female who presented with altered sensorium and loss of consciousness. Imaging studies showed a dura-based solitary mass located in the left frontal lobe. The tumor was excised completely. Histopathology revealed a benign appearing myxoid neoplasm with uniform elongated cells, without any atypia and a very low mitotic activity. Immunohistochemical stains showed positivity for vimentin and epithelial membrane antigen confirming the diagnosis of myxoid meningioma. Only seven cases of myxoid meningioma have been reported till date in the literature and ours is the eighth case.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):267-269
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_111_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Ocular basidiobolomycosis &#8211; Rare presentation: A case report

    • Authors: Vasant Baradkar, Nirjhar Chatterjee, Jayanthi S Shastri, Manoj U Vedpathak
      Pages: 270 - 272
      Abstract: Vasant Baradkar, Nirjhar Chatterjee, Jayanthi S Shastri, Manoj U Vedpathak
      Indian Journal of Pathology and Microbiology 2020 63(2):270-272
      Basidiobolus ranarum is an uncommon pathogen in ocular infections. It has been previously reported from subcutaneous and gastrointestinal infections. Here, we report a rare case of ocular infection caused by B. ranarum. A 21-year-old male patient presented with visual loss and pain in the right eye due to corneal abscess following an injury while welding. KOH mount performed was indicative of fungal hyphae. Fungal culture revealed growth of B. ranarum. Meanwhile, the patient was treated with antifungal (topical natamycin and oral ketoconazole) along with total corneal transplantation. B. ranarum is a fungus very uncommonly causing ocular pathogenesis. This results in diagnostic confusion leading to poor treatment outcomes. Hence, a mycology laboratory has to be aware about this fungus and need to consider it as a differential diagnosis in patients with infectious corneal abscess.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):270-272
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_687_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Lung metastasis, an incidental finding in maxilla &#8211; A case
           report

    • Authors: Sandhya Tamgadge, Treville Pereira, Sandeep Kale, Subraj Shetty, Avinash Tamgadge
      Pages: 273 - 275
      Abstract: Sandhya Tamgadge, Treville Pereira, Sandeep Kale, Subraj Shetty, Avinash Tamgadge
      Indian Journal of Pathology and Microbiology 2020 63(2):273-275
      The aim of this article was to present an asymptomatic lesion with insignificant clinical findings which turned out to be metastatic lesion in the jaws with primary in lung. The most common site of lung metastasis in the orofacial region is the mandible, but in our case it was seen in the maxilla. Metastases to the jaw bones occur in later stages. Hence, a careful examination of patients with jaw bone lesions is strongly suggested. Metastasis to the jaw should be considered while doing oral examination as observed in the current case because such lesions usually develop at terminal stage of cancer.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):273-275
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_325_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Solitary intraosseous neurofibroma of the mandible: Report of an extremely
           rare histopathologic feature

    • Authors: Samira Behrad, Shabnam Sohanian, Arash Ghanbarzadegan
      Pages: 276 - 278
      Abstract: Samira Behrad, Shabnam Sohanian, Arash Ghanbarzadegan
      Indian Journal of Pathology and Microbiology 2020 63(2):276-278
      Neurofibroma (NF) is a benign tumor derived from the peripheral nerve sheath. Neurofibromas may present either as solitary lesions or as part of the generalized syndrome of neurofibromatosis or von Recklinghausen's disease of the skin. The intraosseous variant of NF is very rare. We report a case of a 32-year-old female who was diagnosed with a solitary intraosseous neurofibroma of the mandible. The present case is rare with respect to its unique histopathologic feature.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):276-278
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_28_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Sinusoidal hemangioma with secondary intravascular papillary endothelial
           hyperplasia

    • Authors: Radhika Yajaman Gurumurthy, Nadig Siddharth Shankar, CS Mohan Raj, Nadig Sriram
      Pages: 279 - 281
      Abstract: Radhika Yajaman Gurumurthy, Nadig Siddharth Shankar, CS Mohan Raj, Nadig Sriram
      Indian Journal of Pathology and Microbiology 2020 63(2):279-281
      In this case report, we present a case of a 47-year-old man with sinusoidal hemangioma with secondary intravascular papillary endothelial hyperplasia arising in the subcutaneous tissue. To the best of our knowledge, there are only two cases of sinusoidal hemangioma with secondary intravascular papillary endothelial hyperplasia reported till date, both of which were intramuscular hemangiomas. These are rare entities that also have overlapping histomorphological features with that of various other vascular tumors making histopathological diagnosis troublesome at times. Careful histopathological examination aided by immunohistochemical studies in difficult cases is essential to avoid these diagnostic pitfalls.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):279-281
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_230_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Does IgG4 level evaluation in pancreatic mass play role in avoiding major
           surgery in uncertain presentation: A case report

    • Authors: Rakesh Kumar Gupta, Puja Sakhuja, Hari Govind, Anil Kumar Agarwal
      Pages: 282 - 285
      Abstract: Rakesh Kumar Gupta, Puja Sakhuja, Hari Govind, Anil Kumar Agarwal
      Indian Journal of Pathology and Microbiology 2020 63(2):282-285
      A 66-year-old male presented with chief complaints of anorexia associated with mild dull, intermittent epigastric pain for 6 months. The patient was a known diabetic on oral hypoglycemic and on routine checkup was found to have deranged liver function profile. On radiology, an ill-defined hypoechoic enhancing lesion involving head, neck, and uncinate process of pancreas was noted. Whipple's pancreaticodudenectomy was done and reported as IgG4-related autoimmune pancreatitis. Later, IgG (slightly) and IgG4 were found to be markedly raised. We report this case to highlight the importance of IgG4 evaluation prior to major surgery in uncertain pancreatic mass.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):282-285
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_289_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Primary low-grade mucinous adenocarcinoma spleen resulting in Pseudomyxoma
           peritonei: A case report

    • Authors: Bhumika Gupta, Richa Jindal, Molly Joseph, Kuldeep Kaur, Shikha Chopra, Lipakshi Lakhiani
      Pages: 286 - 288
      Abstract: Bhumika Gupta, Richa Jindal, Molly Joseph, Kuldeep Kaur, Shikha Chopra, Lipakshi Lakhiani
      Indian Journal of Pathology and Microbiology 2020 63(2):286-288
      A 61-year-old man presented with complaints of abdominal pain, loss of weight, and splenomegaly since past 6 months. On computed tomography, the spleen was totally replaced by multiloculated cysts and splenectomy was performed. Pathological examination revealed a low-grade mucinous adenocarcinoma. Postoperative PET scan was negative, and in the absence of a primary tumor elsewhere, we considered this tumor to be primary in the spleen, and it was presumed that the tumor arose from invaginated capsular mesothelium of the spleen.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):286-288
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_624_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Hansen's disease with lepra reaction presenting with IgA dominant
           infection related glomerulonephritis

    • Authors: Elayaperumal Indhumathi, Jeyachandran Dhanapriya, Thanigachalam Dineshkumar, Ramanathan Sakthirajan, Natarajan Gopalakrishnan
      Pages: 289 - 291
      Abstract: Elayaperumal Indhumathi, Jeyachandran Dhanapriya, Thanigachalam Dineshkumar, Ramanathan Sakthirajan, Natarajan Gopalakrishnan
      Indian Journal of Pathology and Microbiology 2020 63(2):289-291
      Various renal abnormalities in leprosy have been described largely in literature but the occurrence of IgA dominant infection related glomerulonephritis in leprosy with type 2 lepra reaction has not been reported so far. We present here a 60-year-old man with a history of leprosy in the past admitted with type 2 lepra reaction, rapidly progressive glomerulonephritis with severe renal failure requiring dialysis and diagnosed to have IgA dominant infection related glomerulonephritis.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):289-291
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_654_17
      Issue No: Vol. 63, No. 2 (2020)
       
  • A case of giant anastomosing hemangioma of the kidney with extramedullary
           hematopoiesis: A great mimicker

    • Authors: Vidhya Manohar, Shantha Krishnamurthy, Jyothi Ranganathan, Vishwas D Pai
      Pages: 292 - 294
      Abstract: Vidhya Manohar, Shantha Krishnamurthy, Jyothi Ranganathan, Vishwas D Pai
      Indian Journal of Pathology and Microbiology 2020 63(2):292-294
      Anastomosing hemangioma (AH) are rare mesenchymal neoplasms affecting kidney with about 50 cases reported in English literature. In general, they are accidentally detected during examination or imaging done for nonspecific symptoms or wellness check-up. There are no key diagnostic features on the imaging modalities. The most common preoperative diagnosis has been a malignant primary renal carcinoma. Surgical resection remains the mainstay of treatment and of choice in symptomatic lesions. We are presenting a rare case of giant AH of the kidney mimicking a renal cell carcinoma on imaging. The lesions are characterized by anastomosing sinusoidal-like vascular spaces lined by banal endothelial cells with occasional hobnail morphology and associated with extramedullary hematopoiesis. The treatment of choice could be a conservative approach in small and asymptomatic lesions and patients with pre-existing renal dysfunction; hence, this entity should be in the differential of vascular renal neoplasms considering its proclivity to the urogenital tract. This is the first case in Indian literature to the best of our knowledge.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):292-294
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_434_18
      Issue No: Vol. 63, No. 2 (2020)
       
  • Endometrial and cervical osseous metaplasia with extramedullary
           haematopoiesis presenting as amenorrhea: Report of three cases

    • Authors: Iffat Jamal, Rakesh K Gupta, Surabhi Raj, Punam P Bhadani
      Pages: 295 - 297
      Abstract: Iffat Jamal, Rakesh K Gupta, Surabhi Raj, Punam P Bhadani
      Indian Journal of Pathology and Microbiology 2020 63(2):295-297
      Endometrial and cervical osseous metaplasia (OM) is a rare phenomenon seen mostly in reproductive age group. Patients generally present with complaints of secondary infertility. Although few cases of endometrial OM have been described in literature, to the best of our knowledge, only six cases of OM in cervix have been reported so far. We report three cases of endometrial OM with extramedullary hematopoiesis, presented with complaints of amenorrhea and secondary infertility. In addition, one of the patients also had cervical OM.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):295-297
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_574_18
      Issue No: Vol. 63, No. 2 (2020)
       
  • A rare case of small cell neuroendocrine tumor of the urinary bladder

    • Authors: B Praveen, Jophy Varghese, H Krishnamoorthy, Biju S Pillai
      Pages: 298 - 300
      Abstract: B Praveen, Jophy Varghese, H Krishnamoorthy, Biju S Pillai
      Indian Journal of Pathology and Microbiology 2020 63(2):298-300
      Small cell neuroendocrine tumor of the bladder is a rare tumor characterized by poor differentiation and high aggressiveness. Very few cases worldwide have been reported till date. Recent literature shows equivalent survival data for localized disease treated with chemoradiotherapy combined with either bladder sparing surgery or radical cystectomy. We report a case of small cell neuroendocrine carcinoma of the bladder diagnosed after transurethral resection of bladder tumor, then followed by adjuvant chemotherapy for six cycles and awaiting radical cystectomy.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):298-300
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_692_18
      Issue No: Vol. 63, No. 2 (2020)
       
  • Spindle cell lipoma, dorsum of hand in a 4 year old child: A rare entity

    • Authors: Parveen Kumar, Nidhi Mahajan, Rishabh Jain, Arti Khatri
      Pages: 301 - 304
      Abstract: Parveen Kumar, Nidhi Mahajan, Rishabh Jain, Arti Khatri
      Indian Journal of Pathology and Microbiology 2020 63(2):301-304
      Lipogenic tumors are an uncommon entity in children. There are several variants of lipoma, of which spindle cell lipoma is an extremely rare and accounts for only 1.5% of all lipoma diagnosis. Spindle cell lipoma rarely involves distal extremities. We report a 4-year old boy with swelling over dorsum of hand operated for aesthetic purposes. The report also highlights the salient cytological features, which can help differentiate this entity from other closer mimics on aspiration cytology, guiding the surgeon for appropriate management.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):301-304
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_475_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Non-bullous neutrophilic lupus erythematosus&#8212;Muted bullous
           disease?

    • Authors: Purnima Malhotra, Preeti Singh, Bijit K Kundu, Minakshi Bhardwaj
      Pages: 305 - 308
      Abstract: Purnima Malhotra, Preeti Singh, Bijit K Kundu, Minakshi Bhardwaj
      Indian Journal of Pathology and Microbiology 2020 63(2):305-308
      Non-bullous neutrophilic lupus erythematosus is a rare form of cutaneous lupus erythematosus (LE). We hereby present a case of 24-year-old female, known case of discoid LE (DLE) with negative ANA stabilized on hydroxychloroquine for 2 years. She reported new occurrence of erythematous, mildly pruritic, papular lesions and painful mucosal ulceration. The ANA became strongly positive by ELISA and urine showed proteinuria. A provisional diagnosis of Rowell syndrome was made, skin biopsy was taken, and patient started on steroids. Histopathology showed interface vacuolar change and many neutrophils in the dermis with leukocytoclasia without any bulla formation. The skin lesions responded promptly to addition of dapsone following biopsy report. We conclude that the presence of neutrophils associated with interface pathology on biopsy represents a muted form of bullous LE, especially in patients on immunosuppression. This case highlights the importance of histopathologic examination in the evaluation of any new skin lesions in a patient of lupus on therapy.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):305-308
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_704_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Cytological diagnosis of primary cutaneous histoplasmosis with
           hemophagocytosis in immunocompetent patient – A rare case from non
           endemic region

    • Authors: Smita Chandra, Manveer K Raina, Dushyant S Gaur, Vinish K Agarwal
      Pages: 309 - 311
      Abstract: Smita Chandra, Manveer K Raina, Dushyant S Gaur, Vinish K Agarwal
      Indian Journal of Pathology and Microbiology 2020 63(2):309-311
      Histoplasma capsulatum is an opportunistic dimorphic fungus caused by inhalation of spores present in the soil. It is extremely rare in the northern Himalayan region of India and is usually asymptomatic. It may rarely progress to disseminated histoplasmosis which is usually observed in immunocompromised patients associated with malignancy, acquired immunodeficiency syndrome or diabetes. The present case is being reported because of unusual cutaneous presentation of disseminated histoplasmosis in an immunocompetent patient of non-endemic region. The case also highlights the importance of fine needle aspiration cytology for its precise early diagnosis and avoiding of further complications.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):309-311
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_792_18
      Issue No: Vol. 63, No. 2 (2020)
       
  • A progressive neurological condition with acquired sea-blue histiocytosis
           further the diagnosis of Niemann-Pick type C1 in a 10-year-old boy

    • Authors: Li Wang, Jingmin Sun, Xiaoyan Xu, Longxiang Tao, De Wu, Ying Zhang
      Pages: 312 - 314
      Abstract: Li Wang, Jingmin Sun, Xiaoyan Xu, Longxiang Tao, De Wu, Ying Zhang
      Indian Journal of Pathology and Microbiology 2020 63(2):312-314
      Sea-blue histiocytes in bone marrow can be associated with a number of conditions and have indeed often been reported in Niemann-Pick diseases, mostly in Niemann-Pick type B, but also Niemann-Pick type C. Rarely, it was reported to be related to a progressive neurological condition. In this work, early bone marrow aspirations in a boy following the discovery of hepatosplenomegaly at 1 month of age and later isolated splenomegaly did not reveal abnormal cells (which is not uncommon). Numerous sea-blue histiocytes were found in a repeated exam when the child was 10-year old, at a time he had developed a progressive neurological condition with frequent falls, clumsiness, slow and slurred speech, intellectual disability, dystonic movements, and dysphagia. Acquired sea-blue histiocytes should be considered initially on the basis of clinical symptoms. Whole-exome sequencing identified two variants in the NPC1 gene, leading to the diagnosis of Niemann-Pick type C1. This case points out the presence of sea-blue histiocytes in the bone marrow and has helped to reach a diagnosis of NPC1 which was very difficult to establish even after years of study. Given the rarity of this pathology and the variety of clinical presentations, it is important to communicate the possible forms of presentation of this syndrome.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):312-314
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_728_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Granuloma in marrow with lurking &#8220;Leuk&#8221;: Two
           happenstances

    • Authors: Saraswathy Sreeram, Sridevi Hanaganahalli Basavaiah, Nirupama Murali, Prashantha Balanthimogru
      Pages: 315 - 318
      Abstract: Saraswathy Sreeram, Sridevi Hanaganahalli Basavaiah, Nirupama Murali, Prashantha Balanthimogru
      Indian Journal of Pathology and Microbiology 2020 63(2):315-318
      Granulomas are described very rarely in marrow biopsies. They have hardly been reported in association with acute lymphoblastic leukemia. We herein report two cases of ALL associated with granulomas each at different stage of their clinical course that led to a diagnostic and therapeutic dilemma. First case was of a 42-year-old woman diagnosed with tuberculosis who presented with bleeding gums during anti-tubercular therapy. In the second scenario, a 51-year-old man presented with pyrexia of unknown origin and splenomegaly who was put on a trial of ATT. Peripheral smear showed only 1–2% abnormal cells, however, bone marrow aspiration and flow cytometry pattern was diagnostic of ALL. Both the patients received chemotherapy and have been on remission so far. These case scenarios put forward a relevant question on this rare coexistence, as the implications on management are manifold.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):315-318
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_96_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Anomalies in milk line: Case report of two cases

    • Authors: Mani Krishna, Taiba Khan, Asim Khan
      Pages: 319 - 321
      Abstract: Mani Krishna, Taiba Khan, Asim Khan
      Indian Journal of Pathology and Microbiology 2020 63(2):319-321
      Congenital anomalies of breast, especially polymastia and polythelia, confuse clinicians because of their varied presentations, associated renal anomalies, and pathologies arising in them. Case 1: A 30-year-old Asian Indian female presented with swelling in left inguinal region since 2 years, increased in size in last 2 months with history of milk discharge. Diagnosis of ectopic breast tissue inguinal region with lactational changes was made on fine-needle aspiration cytology (FNAC). Case 2: A 28-year-old female presented with complaints of bilateral axillary mass for 2 years which is gradually increasing in size and associated with pain and discomfort along with intrareolar polythalia (left breast). FNAC was done from both axillary swelling which came out to be the fibroadenoma in ectopic breast tissue. Both the cases are discussed because of their rarity and to screen ectopic breast tissue for any pathology during routine screening of breast.
      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):319-321
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_281_18
      Issue No: Vol. 63, No. 2 (2020)
       
  • Colonic malakoplakia in a cardiac transplant recipient: A case report

    • Authors: Sadiya Shafijan
      Pages: 322 - 324
      Abstract: Sadiya Shafijan
      Indian Journal of Pathology and Microbiology 2020 63(2):322-324

      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):322-324
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_144_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Bubbly bowel: A life-threatening condition

    • Authors: Divya S Shetty, Leena P Naik, Anjali D Amarapurkar
      Pages: 325 - 326
      Abstract: Divya S Shetty, Leena P Naik, Anjali D Amarapurkar
      Indian Journal of Pathology and Microbiology 2020 63(2):325-326

      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):325-326
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_474_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Oncocytic variant of papillary renal cell carcinoma: A rare or
           underreported entity?

    • Authors: Ashutosh Rath, Wonchibeni T Murry, Varuna Mallya, Nita Khurana, Sudhir Kumar Jain
      Pages: 327 - 329
      Abstract: Ashutosh Rath, Wonchibeni T Murry, Varuna Mallya, Nita Khurana, Sudhir Kumar Jain
      Indian Journal of Pathology and Microbiology 2020 63(2):327-329

      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):327-329
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_424_18
      Issue No: Vol. 63, No. 2 (2020)
       
  • Intraconal dermoid cyst &#8211; A common condition at uncommon
           location and age

    • Authors: Archana N Rijhsinghani, Nikhil K Majethia
      Pages: 330 - 331
      Abstract: Archana N Rijhsinghani, Nikhil K Majethia
      Indian Journal of Pathology and Microbiology 2020 63(2):330-331

      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):330-331
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_590_18
      Issue No: Vol. 63, No. 2 (2020)
       
  • Squamous cell carcinoma larynx with concurrent Warthin's tumor of the
           submandibular gland: A rarely reported co-existence

    • Authors: Utpal Kumar, Bindu Rajkumar, Arvind Kumar, Sanjeev Kishore, Bhinyaram Jat
      Pages: 331 - 333
      Abstract: Utpal Kumar, Bindu Rajkumar, Arvind Kumar, Sanjeev Kishore, Bhinyaram Jat
      Indian Journal of Pathology and Microbiology 2020 63(2):331-333

      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):331-333
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_436_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • Brunner&#39;s gland hamartoma presenting as large duodenal polyp

    • Authors: Smita Nath, Gadadhar Panda, Rahul Karna, Naresh Kumar, Ravindra K Saran, Premashis Kar
      Pages: 334 - 335
      Abstract: Smita Nath, Gadadhar Panda, Rahul Karna, Naresh Kumar, Ravindra K Saran, Premashis Kar
      Indian Journal of Pathology and Microbiology 2020 63(2):334-335

      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):334-335
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_650_18
      Issue No: Vol. 63, No. 2 (2020)
       
  • Amyloidosis presenting as right adrenal mass—diagnosed on endoscopic
           ultrasound-guided fine needle aspiration

    • Authors: Abha Thakur, Haimanti Sarin, Narendra S Choudhary, Ishani Mohapatra, Rajesh Puri, AS Soin
      Pages: 335 - 337
      Abstract: Abha Thakur, Haimanti Sarin, Narendra S Choudhary, Ishani Mohapatra, Rajesh Puri, AS Soin
      Indian Journal of Pathology and Microbiology 2020 63(2):335-337

      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):335-337
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_575_19
      Issue No: Vol. 63, No. 2 (2020)
       
  • A rare case of primary signet ring-like cell carcinoma of prostate in an
           elderly male

    • Authors: Avinash Gupta, Hanni Vasudev Gulwani
      Pages: 338 - 339
      Abstract: Avinash Gupta, Hanni Vasudev Gulwani
      Indian Journal of Pathology and Microbiology 2020 63(2):338-339

      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):338-339
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_172_18
      Issue No: Vol. 63, No. 2 (2020)
       
  • A rare case of therapy-associated acute megakaryoblastic leukemia

    • Authors: Roshini Shekhar, Amit Rauthan, Swati Pai
      Pages: 339 - 341
      Abstract: Roshini Shekhar, Amit Rauthan, Swati Pai
      Indian Journal of Pathology and Microbiology 2020 63(2):339-341

      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):339-341
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_579_18S
      Issue No: Vol. 63, No. 2 (2020)
       
  • Catechism (Quiz 8)

    • Authors: Mona Agnihotri, Kanchan Kothari, Ameya Khadilkar
      Pages: 342 - 344
      Abstract: Mona Agnihotri, Kanchan Kothari, Ameya Khadilkar
      Indian Journal of Pathology and Microbiology 2020 63(2):342-344

      Citation: Indian Journal of Pathology and Microbiology 2020 63(2):342-344
      PubDate: Sat,18 Apr 2020
      DOI: 10.4103/IJPM.IJPM_15_20
      Issue No: Vol. 63, No. 2 (2020)
       
 
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