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Publisher: Medknow Publishers   (Total: 356 journals)

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Showing 1 - 200 of 356 Journals sorted alphabetically
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advances in Human Biology     Open Access  
African J. for Infertility and Assisted Conception     Open Access  
African J. of Business Ethics     Open Access   (Followers: 7)
African J. of Medical and Health Sciences     Open Access  
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.269, h-index: 10)
African J. of Trauma     Open Access  
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access  
Ancient Science of Life     Open Access   (Followers: 6)
Anesthesia : Essays and Researches     Open Access   (Followers: 7)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.331, h-index: 15)
Annals of Bioanthropology     Open Access   (Followers: 2)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 12, SJR: 0.408, h-index: 15)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.308, h-index: 14)
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 5, SJR: 0.441, h-index: 10)
Annals of Saudi Medicine     Open Access   (SJR: 0.24, h-index: 29)
Annals of Thoracic Medicine     Open Access   (Followers: 4, SJR: 0.388, h-index: 19)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 15, SJR: 0.148, h-index: 5)
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Intl. Surgery     Open Access   (Followers: 9)
Archives of Medicine and Health Sciences     Open Access   (Followers: 2)
Archives of Pharmacy Practice     Open Access   (Followers: 4)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 3)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.879, h-index: 49)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.362, h-index: 10)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access   (Followers: 1)
Bulletin of Faculty of Physical Therapy     Open Access  
Cancer Translational Medicine     Open Access   (Followers: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Dermatology Review     Open Access  
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 10, SJR: 0.82, h-index: 12)
Contemporary Clinical Dentistry     Open Access   (Followers: 4)
Current Medical Issues     Open Access  
CytoJ.     Open Access   (Followers: 2, SJR: 0.339, h-index: 19)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.131, h-index: 4)
Dental Research J.     Open Access   (Followers: 9)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 4, SJR: 0.205, h-index: 22)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access  
Egyptian J. of Dermatology and Venerology     Open Access  
Egyptian J. of Haematology     Open Access  
Egyptian J. of Internal Medicine     Open Access  
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.121, h-index: 3)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access  
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Orthopaedic J.     Open Access  
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.473, h-index: 8)
Environmental Disease     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.496, h-index: 11)
European J. of General Dentistry     Open Access   (Followers: 1)
European J. of Prosthodontics     Open Access   (Followers: 2)
European J. of Psychology and Educational Studies     Open Access   (Followers: 6)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.107, h-index: 5)
Genome Integrity     Open Access   (Followers: 4, SJR: 1.227, h-index: 12)
Global J. of Transfusion Medicine     Open Access  
Heart India     Open Access  
Heart Views     Open Access  
Hepatitis B Annual     Open Access   (Followers: 3)
IJS Short Reports     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 2)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.302, h-index: 13)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (SJR: 0.318, h-index: 26)
Indian J. of Cerebral Palsy     Open Access  
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.618, h-index: 16)
Indian J. of Critical Care Medicine     Open Access   (Followers: 1, SJR: 0.307, h-index: 16)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.243, h-index: 24)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.448, h-index: 16)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 2, SJR: 0.563, h-index: 29)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access  
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4)
Indian J. of Health Sciences     Open Access   (Followers: 1)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.292, h-index: 9)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.53, h-index: 34)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.716, h-index: 60)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.207, h-index: 31)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 1, SJR: 0.233, h-index: 12)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.213, h-index: 5)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 4, SJR: 0.203, h-index: 13)
Indian J. of Ophthalmology     Open Access   (Followers: 3, SJR: 0.536, h-index: 34)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 9, SJR: 0.393, h-index: 15)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.218, h-index: 5)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 1)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.35, h-index: 12)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 1, SJR: 0.285, h-index: 22)
Indian J. of Pharmacology     Open Access   (SJR: 0.347, h-index: 44)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.303, h-index: 13)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.496, h-index: 15)
Indian J. of Psychological Medicine     Open Access   (Followers: 1, SJR: 0.344, h-index: 9)
Indian J. of Public Health     Open Access   (Followers: 1, SJR: 0.444, h-index: 17)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4, SJR: 0.253, h-index: 14)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.169, h-index: 7)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.313, h-index: 9)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.366, h-index: 16)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Critical Illness and Injury Science     Open Access  
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 2)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 4, SJR: 0.229, h-index: 13)
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 1)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 2)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 7)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.239, h-index: 4)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.523, h-index: 15)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 6, SJR: 0.611, h-index: 9)
Intl. J. of Trichology     Open Access   (SJR: 0.37, h-index: 10)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 2)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 4, SJR: 0.427, h-index: 15)
J. of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 8, SJR: 0.416, h-index: 14)
J. of Applied Hematology     Open Access  
J. of Association of Chest Physicians     Open Access   (Followers: 2)
J. of Basic and Clinical Reproductive Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Therapeutics     Open Access   (Followers: 4, SJR: 0.359, h-index: 21)
J. of Carcinogenesis     Open Access   (Followers: 1, SJR: 1.152, h-index: 26)
J. of Cardiothoracic Trauma     Open Access  
J. of Cardiovascular Disease Research     Open Access   (Followers: 3, SJR: 0.351, h-index: 13)
J. of Cardiovascular Echography     Open Access   (SJR: 0.134, h-index: 2)
J. of Cleft Lip Palate and Craniofacial Anomalies     Open Access   (Followers: 2)
J. of Clinical and Preventive Cardiology     Open Access  
J. of Clinical Imaging Science     Open Access   (Followers: 1, SJR: 0.277, h-index: 8)
J. of Clinical Neonatology     Open Access   (Followers: 1)
J. of Clinical Ophthalmology and Research     Open Access   (Followers: 1)
J. of Clinical Sciences     Open Access  
J. of Conservative Dentistry     Open Access   (Followers: 4, SJR: 0.532, h-index: 10)
J. of Craniovertebral Junction and Spine     Open Access   (Followers: 4, SJR: 0.199, h-index: 9)
J. of Current Medical Research and Practice     Open Access  
J. of Current Research in Scientific Medicine     Open Access  
J. of Cutaneous and Aesthetic Surgery     Open Access   (Followers: 1)
J. of Cytology     Open Access   (Followers: 1, SJR: 0.274, h-index: 9)
J. of Dental and Allied Sciences     Open Access   (Followers: 1)
J. of Dental Implants     Open Access   (Followers: 7)
J. of Dental Lasers     Open Access   (Followers: 2)
J. of Dental Research and Review     Open Access   (Followers: 1)
J. of Digestive Endoscopy     Open Access   (Followers: 3)
J. of Dr. NTR University of Health Sciences     Open Access  
J. of Earth, Environment and Health Sciences     Open Access   (Followers: 1)
J. of Education and Ethics in Dentistry     Open Access   (Followers: 5)
J. of Education and Health Promotion     Open Access   (Followers: 5)
J. of Emergencies, Trauma and Shock     Open Access   (Followers: 8, SJR: 0.353, h-index: 14)
J. of Engineering and Technology     Open Access   (Followers: 6)
J. of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
J. of Family and Community Medicine     Open Access  
J. of Family Medicine and Primary Care     Open Access   (Followers: 8)

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Journal Cover CytoJournal
  [SJR: 0.339]   [H-I: 19]   [2 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 1742-6413 - ISSN (Online) 1742-6413
   Published by Medknow Publishers Homepage  [356 journals]
  • Evaluation of polymerase chain reaction in space-occupying lesions of
           liver reported as granulomatous inflammation/tuberculosis on fine-needle
           aspiration cytology

    • Authors: Kusum Sharma, Nalini Gupta, Kapil Goyal, Ajay Kumar Duseja, Aman Sharma, Arvind Rajwanshi
      Pages: 1 - 1
      Abstract: Kusum Sharma, Nalini Gupta, Kapil Goyal, Ajay Kumar Duseja, Aman Sharma, Arvind Rajwanshi
      CytoJournal 2017 14(1):1-1
      Background: Tubercular involvement of the liver is uncommon, but is a serious consideration in differential diagnosis of granulomatous conditions, especially in endemic regions like India. Objective: To assess the role of polymerase chain reaction (PCR) done on archival cytological material in diagnosing tuberculosis (TB) in cases reported as granulomatous inflammation/TB in liver lesions. Materials and Methods: This was a retrospective study including a total of 17 cases of liver space-occupying lesions (SOLs) reported as granulomatous inflammation (n = 12) and TB (n = 5). The smears were retrieved from the archives of the department and were reviewed for the cytomorphologic features. Air-dried smears stained with May–Grünwald–Giemsa (MGG) stain were assessed for the representative material in the form of epithelioid granulomas and giant cells. One/two MGG smears from each case were destained and the material was used for performing PCR for Mycobacterium tuberculosis by amplification of 123 bp fragment of the IS6110 insertion element. Results: The age of the patients ranged from 3 to 61 years. There were 12 females and 5 males. The patients presented with solitary/multiple liver SOLs. DNA could be extracted from 10/17 cases from archival MGG smears. PCR positivity was noted in 8/10 cases (including four acid-fast bacilli smear-positive cases), confirming a diagnosis of TB. Conclusion: Cytomorphology alone may not be sufficient for differentiating various granulomatous lesions reported in liver SOLs. DNA can be extracted from the archival cytological MGG-stained smears. PCR should be carried out if Ziehl–Neelsen staining is negative in granulomatous lesions, especially when material has not been submitted for culture.
      Citation: CytoJournal 2017 14(1):1-1
      PubDate: Fri,20 Jan 2017
      DOI: 10.4103/1742-6413.198815
      Issue No: Vol. 14, No. 1 (2017)
       
  • Primary orbital mantle cell lymphoma: Flow cytometric immunophenotyping as
           an adjunct to fine-needle aspiration cytology for diagnosis

    • Authors: Sangeeta Verma, Nalini Gupta, Satyawati Mohindra, Manupdesh Singh Sachdeva, Arvind Rajwanshi
      Pages: 2 - 2
      Abstract: Sangeeta Verma, Nalini Gupta, Satyawati Mohindra, Manupdesh Singh Sachdeva, Arvind Rajwanshi
      CytoJournal 2017 14(1):2-2

      Citation: CytoJournal 2017 14(1):2-2
      PubDate: Fri,20 Jan 2017
      DOI: 10.4103/1742-6413.198816
      Issue No: Vol. 14, No. 1 (2017)
       
  • Thyroid fine-needle aspiration of an immunocompromised patient:
           Cytomorphological clues

    • Authors: Longwen Chen, Nirvikar Dahiya, Matthew A Zarka
      Pages: 3 - 3
      Abstract: Longwen Chen, Nirvikar Dahiya, Matthew A Zarka
      CytoJournal 2017 14(1):3-3

      Citation: CytoJournal 2017 14(1):3-3
      PubDate: Fri,24 Feb 2017
      DOI: 10.4103/1742-6413.200934
      Issue No: Vol. 14, No. 1 (2017)
       
  • Detection of BRAF mutation in the cytocentrifugation supernatant fluid
           from fine-needle aspiration of thyroid lesions may enhance the diagnostic
           yield

    • Authors: Ashley E Brown, Khin Sandar Lim, George Corpus, Martha T Hustek, Tien Anh N Tran, Chung-Che Chang
      Pages: 4 - 4
      Abstract: Ashley E Brown, Khin Sandar Lim, George Corpus, Martha T Hustek, Tien Anh N Tran, Chung-Che Chang
      CytoJournal 2017 14(1):4-4
      Objective: BRAF mutations using cellular DNA from fine-needle aspiration (FNA) specimens are commonly used to support the diagnosis of papillary thyroid carcinoma (PTC). The goal of this study was to preliminarily evaluate the diagnostic utility of detecting BRAF mutations in the routinely discarded FNA specimen supernatant fluid. Materials and Methods: Seventy-eight FNAs of thyroid lesions were evaluated for BRAF mutations using both cellular and supernatant DNA. BRAF mutation data were correlated with cytology and surgical pathology. Results: Of the 78 samples evaluated, 68 (87%) had amplifiable DNA in the supernatant with 2 (3%) positive for BRAF mutations. These two samples showed no mutations in the cellular counterpart. Among the 11 samples showing morphologic findings (FNA/surgical pathology) suspicious/diagnostic of PTC, 6 (55%) samples (one supernatant and five cellulars) were positive for BRAF mutations. This suggests that testing supernatant DNA in FNA specimens may increase the diagnostic yield by 1/11 (9%) in this setting. Conclusions: The vast majority of routinely discarded FNA supernatants contain amplifiable DNA. In addition, profiling the mutations of BRAF and other genes using supernatant DNA may provide valuable diagnostic information to assist the diagnosis of PTC in patients with clinical/morphologic findings suspicious for malignancies and cellular DNA showing no mutations.
      Citation: CytoJournal 2017 14(1):4-4
      PubDate: Fri,24 Feb 2017
      DOI: 10.4103/1742-6413.200935
      Issue No: Vol. 14, No. 1 (2017)
       
  • KRAS detection on archival cytological smears by the novel fully automated
           polymerase chain reaction-based Idylla mutation test

    • Authors: Caterina De Luca, Elena Vigliar, Melania d'Anna, Pasquale Pisapia, Claudio Bellevicine, Umberto Malapelle, Giancarlo Troncone
      Pages: 5 - 5
      Abstract: Caterina De Luca, Elena Vigliar, Melania d'Anna, Pasquale Pisapia, Claudio Bellevicine, Umberto Malapelle, Giancarlo Troncone
      CytoJournal 2017 14(1):5-5
      Background: Molecular techniques are relevant to modern cytopathology, but their implementation is difficult without molecular expertise and infrastructure. The assessment of KRAS mutational status on cytological preparations may be useful either to refine uncertain diagnoses on pancreatic aspirates or to yield predictive information to plan targeted treatment of metastatic colorectal cancer (mCRC). The novel test Idylla™ enables fully automated KRAS genotyping in approximately 2 h, even in less experienced hands. Materials and Methods: This study aims to validate this methodology to detect KRAS mutations on archival cytological preparations of pancreatic cancer (n = 9) and mCRC (n = 9) by comparing the Idylla™ performance to that of standard real-time polymerase chain reaction. Results: The same 11 mutations (n = 4: p.G12D; n = 2: p.G12V; n = 2: p.A59E/G/T; n = 1: p.G12R; n = 1: p.G13D; n = 1: p.Q61H) were detected by both techniques. Conclusion: Even in less experienced laboratories, a cytopathologist may easily integrate morphological diagnostic report with accurate KRAS mutation detection, which is relevant for diagnostic and treatment decisions.
      Citation: CytoJournal 2017 14(1):5-5
      PubDate: Fri,24 Feb 2017
      DOI: 10.4103/1742-6413.200936
      Issue No: Vol. 14, No. 1 (2017)
       
  • Falling under the umbrella cells: A single institutional experience and
           literature review of urothelial carcinoma presenting as a primary
           pancreatic mass on endoscopic ultrasound-guided fine-needle aspiration

    • Authors: Michael Chambers, Konrad Krall, Shantel Hébert-Magee
      Pages: 6 - 6
      Abstract: Michael Chambers, Konrad Krall, Shantel Hébert-Magee
      CytoJournal 2017 14(1):6-6
      Metastases to the pancreas are much less common than primary pancreatic lesions, and there are few reports in the literature of metastatic urothelial carcinoma (UC) found in the pancreas. We report two cases of metastatic UC mimicking a primary pancreatic lesion. Two female patients, aged 48 and 83 years, presented with isolated pancreatic lesions causing obstructive jaundice suspicious for pancreatic adenocarcinoma and underwent endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) with rapid on-site evaluation (ROSE). On cytopathology, the lesions were found to be UC, confirmed with immunohistochemical (IHC) staining. UC rarely metastasizes to the pancreas, and diagnosis through EUS-FNA can be challenging. However, the utilization of ROSE, dedicated cell block passes, and IHC have proved to be effective in obtaining this unusual pancreatic diagnosis by EUS-FNA.
      Citation: CytoJournal 2017 14(1):6-6
      PubDate: Mon,20 Mar 2017
      DOI: 10.4103/1742-6413.202601
      Issue No: Vol. 14, No. 1 (2017)
       
  • Next-generation sequencing of non-small cell lung cancer using a
           customized, targeted sequencing panel: Emphasis on small biopsy and
           cytology

    • Authors: David M DiBardino, David W Rawson, Anjali Saqi, Jonas J Heymann, Carlos A Pagan, William A Bulman
      Pages: 7 - 7
      Abstract: David M DiBardino, David W Rawson, Anjali Saqi, Jonas J Heymann, Carlos A Pagan, William A Bulman
      CytoJournal 2017 14(1):7-7
      Background: Next-generation sequencing (NGS) with a multi-gene panel is now available for patients with lung adenocarcinoma, but the performance characteristics and clinical utility of this testing are not well-described. We present the results of an extended 467 gene panel in a series of advanced, highly selected nonsmall cell lung cancer (NSCLC) patients using a range of specimens, including predominantly small biopsy and cytology specimens. Materials and Methods: A retrospective review of 22 NSCLC biopsies sent for NGS using an extended gene panel from January 2014 to July 2015. The customized NGS panel sequences 467 cancer-associated genes with exonic and intronic sequences obtained from purified tumor DNA. Genomic alterations, patient characteristics, and success of testing were determined. Results: The majority of samples tested were metastatic lung adenocarcinoma on final pathology. Of the 22 specimens tested, 5 (22.7%) were surgical resections and 17 (77.3%) were small biopsy and cytology specimens. Twenty-one (95%) of the specimens were adequate for full sequencing and yielded a total of 204 genomic alterations (average 8.9 per tumor), of which 17 (average 0.81 per tumor) were actionable and/or clinically relevant. Genomic alterations were found most commonly in the TP53, EGFR, EPHB1, MLL3, APC, SETD2, KRAS, DNMT3A, RB1, CDKN2A, ARID1A, EP300, KDM6B, RAD50, STK11, and BRCA2 genes. Conclusions: NGS using a comprehensive gene panel was performed successfully in 95% of all NSCLC cases in this series, including 94% small biopsy and cytology specimens and 100% surgical resections. This custom assay was performed on a range of tumor specimens and demonstrates that small specimens are able to provide a similar depth of information as larger ones. As many patients present at an advanced stage and only small specimens are obtained, the information these provide has the potential for guiding treatment in highly selected patients with advanced lung adenocarcinoma.
      Citation: CytoJournal 2017 14(1):7-7
      PubDate: Mon,20 Mar 2017
      DOI: 10.4103/1742-6413.202602
      Issue No: Vol. 14, No. 1 (2017)
       
  • Ultrasound-guided fine-needle aspiration of hyperenhancing lesion
           suspicious for pancreatic neuroendocrine tumor in the tail of
           pancreas-potential pitfalls

    • Authors: Kinda Hayek, Tatyana Kalinicheva, Vinod B Shidham
      Pages: 8 - 8
      Abstract: Kinda Hayek, Tatyana Kalinicheva, Vinod B Shidham
      CytoJournal 2017 14(1):8-8

      Citation: CytoJournal 2017 14(1):8-8
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/1742-6413.205311
      Issue No: Vol. 14, No. 1 (2017)
       
  • Indian visceral leishmaniasis with extensive lymphadenopathy – An
           unusual presentation: A case report with literature review

    • Authors: Poojan Agarwal, Vijay Kumar, Manju Kaushal, Manju Kumari, Arvind Chaudhary
      Pages: 9 - 9
      Abstract: Poojan Agarwal, Vijay Kumar, Manju Kaushal, Manju Kumari, Arvind Chaudhary
      CytoJournal 2017 14(1):9-9
      Visceral leishmaniasis (VL), also known as kala-azar, is a life-threatening systemic disease caused by the obligate intracellular protozoan, Leishmania, and transmitted to humans by the female phlebotomine sand fly (Phlebotomus argentipes). The disease is fatal, if left untreated. We report a case of a patient clinically suspected of disseminated tuberculosis, but fine needle aspiration cytology of cervical and axillary lymph nodes yielded a diagnosis of leishmaniasis. Diagnosis of VL was challenging as the disease closely mimicked tuberculosis in the setting of extensive lymphadenopathy including conglomerate of mesenteric lymph nodes, on and off fever, and granulomatous lymphadenitis on aspiration. Bone marrow examination was further performed. A detailed workup revealed patient to be severely immunocompromised and newly diagnosed human immunodeficiency virus (HIV) positive. Worldwide, India has the largest number of VL cases, accounting for 40%–50% of world's disease burden and the second largest HIV-infected population, accounting for approximately 10% of the global disease burden. HIV increases the risk of developing VL by 100–2320 times in endemic areas and concurrently VL promotes the clinical progression of HIV disease. Co-infection with HIV alters the body's immune response to leishmaniasis thus leading to unusual presentations. This case highlights the diagnostic problem in the aforesaid setting. Moreover, co-infection with HIV in VL can be a potential source of drug resistance. An early diagnosis and intensified treatment is the key to patient management.
      Citation: CytoJournal 2017 14(1):9-9
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/1742-6413.205312
      Issue No: Vol. 14, No. 1 (2017)
       
  • Cytomorphologic features distinguishing Bethesda category IV thyroid
           lesions from parathyroid

    • Authors: Simon Sung, Anjali Saqi, Elizabeth M Margolskee, John P Crapanzano
      Pages: 10 - 10
      Abstract: Simon Sung, Anjali Saqi, Elizabeth M Margolskee, John P Crapanzano
      CytoJournal 2017 14(1):10-10
      Background: Thyroid follicular cells share similar cytomorphological features with parathyroid. Without a clinical suspicion, the distinction between a thyroid neoplasm and an intrathyroidal parathyroid can be challenging. The aim of this study was to assess the distinguishing cytomorphological features of parathyroid (including intrathyroidal) and Bethesda category IV (Beth-IV) thyroid follicular lesions, which carry a 15%–30% risk of malignancy and are often followed up with surgical resection. Methods: A search was performed to identify “parathyroid” diagnoses in parathyroid/thyroid-designated fine-needle aspirations (FNAs) and Beth-IV thyroid FNAs (follicular and Hurthle cell), all with diagnostic confirmation through surgical pathology, immunocytochemical stains, Afirma® analysis, and/or clinical correlation. Unique cytomorphologic features were scored (0-3) or noted as present versus absent. Statistical analysis was performed using R 3.3.1 software. Results: We identified five FNA cases with clinical suspicion of parathyroid neoplasm, hyperthyroidism, or thyroid lesion that had an eventual final diagnosis of the parathyroid lesion (all female; age 20–69 years) and 12 Beth-IV diagnoses (11 female, 1 male; age 13–64 years). The following cytomorphologic features are useful distinguishing features (P value): overall pattern (0.001), single cells (0.001), cell size compared to red blood cell (0.01), nuclear irregularity (0.001), presence of nucleoli (0.001), nuclear-to-cytoplasmic ratio (0.007), and nuclear chromatin quality (0.028). Conclusions: There are cytomorphologic features that distinguish Beth-IV thyroid lesions and (intrathyroidal) parathyroid. These features can aid in rendering correct diagnoses and appropriate management.
      Citation: CytoJournal 2017 14(1):10-10
      PubDate: Fri,28 Apr 2017
      DOI: 10.4103/1742-6413.205313
      Issue No: Vol. 14, No. 1 (2017)
       
  • Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary
           tumors involving the pancreas: An institution's experience

    • Authors: Almed K Alomari, Berrin Ustun, Harry R Aslanian, Xinquan Ge, David Chhieng, Guoping Cai
      Pages: 1 - 1
      Abstract: Almed K Alomari, Berrin Ustun, Harry R Aslanian, Xinquan Ge, David Chhieng, Guoping Cai
      CytoJournal 2016 13(1):1-1
      Background: Pancreatic masses may seldom represent a metastasis or secondary involvement by lymphoproliferative disorders. Recognition of this uncommon occurrence may help render an accurate diagnosis and avoid diagnostic pitfalls during endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). In this study, we review our experience in diagnosing secondary tumors involving the pancreas. Materials and Methods: The electronic database of cytopathology archives was searched for cases of secondary tumors involving the pancreas at our institution and a total of 31 cases were identified. The corresponding clinical presentations, imaging study findings, cytological diagnoses, the results of ancillary studies, and surgical follow-up, if available, were reviewed. Results: Nineteen of the patients were male and 12 female, with a mean age of 66 years. Twenty-three patients (74%) had a prior history of malignancy, with the latency ranging from 6 months to 19 years. The secondary tumors involving the pancreas included metastatic carcinoma (24 cases), metastatic sarcoma (3 cases), diffuse large B-cell lymphoma (2 cases), and plasma cell neoplasm (2 cases). The most common metastatic tumors were renal cell carcinoma (8 cases) and lung carcinoma (7 cases). Correct diagnoses were rendered in 29 cases (94%). The remaining two cases were misclassified as primary pancreatic carcinoma. In both cases, the patients had no known history of malignancy, and no ancillary studies were performed. Conclusions: Secondary tumors involving the pancreas can be accurately diagnosed by EUS-FNA. Recognizing uncommon cytomorphologic features, knowing prior history of malignancy, and performing ancillary studies are the keys to improve diagnostic performance and avoid diagnostic pitfalls.
      Citation: CytoJournal 2016 13(1):1-1
      PubDate: Thu,28 Jan 2016
      DOI: 10.4103/1742-6413.173585
      Issue No: Vol. 13, No. 1 (2016)
       
  • Primary ovarian non-Hodgkin lymphoma: Diagnosis of two cases on fine
           needle aspiration cytology

    • Authors: Rajni Yadav, Partheeban Balasundaram, Asit R Mridha, Venkateswaran K Iyer, Sandeep R Mathur
      Pages: 2 - 2
      Abstract: Rajni Yadav, Partheeban Balasundaram, Asit R Mridha, Venkateswaran K Iyer, Sandeep R Mathur
      CytoJournal 2016 13(1):2-2
      Lymphoma of the female genital tract is a rare condition. Involvement of the ovary by non- Hodgkin lymphoma (NHL) is usually secondary to systemic disease and primary ovarian lymphomas are unusual. In most cases, the diagnosis is not suspected initially and is confirmed only after detailed histopathological evaluation. We describe two cases of primary ovarian NHL which were diagnosed on fine needle aspiration cytology (FNAC). One of the patients was a 40 years old female who presented with abdominal distension and lump. She was found to have bilateral adnexal masses on ultrasound and computed tomography (CT) scan. A USG guided fine needle aspiration of the ovarian masses was performed, following which a diagnosis of primary ovarian diffuse large B-cell lymphoma was established. The second patient was a 14 years old female who presented with pelvic lump, which was lobulated and mildly enhancing on contrast enhanced CT. A diagnosis of high grade NHL of ovaries was made on cytology. Subsequently, the lymphoma was characterized as Burkitt's on histopathological examination. Both the patients were started on R-CHOP chemotherapy regimen. FNAC serves as an extremely useful minimally invasive procedure for the diagnosis of ovarian lymphomas and early institution of appropriate chemotherapeutic regimens.
      Citation: CytoJournal 2016 13(1):2-2
      PubDate: Thu,28 Jan 2016
      DOI: 10.4103/1742-6413.173588
      Issue No: Vol. 13, No. 1 (2016)
       
  • Detecting uterine glandular lesions: Role of cervical cytology

    • Authors: Baneet Bansal, Parikshaa Gupta, Nalini Gupta, Arvind Rajwanshi, Vanita Suri
      Pages: 3 - 3
      Abstract: Baneet Bansal, Parikshaa Gupta, Nalini Gupta, Arvind Rajwanshi, Vanita Suri
      CytoJournal 2016 13(1):3-3
      Background: The sensitivity of cervical cytology for detection of glandular lesions is reported to be low. We conducted this study to assess the diagnostic accuracy of cervical Papanicolaou (Pap) smears for uterine glandular lesions and to compare the diagnostic utility of conventional and liquid-based cytology (LBC) smears for glandular lesions. Materials and Methods: Archived histopathology records of all cases reported as endocervical and endometrial adenocarcinoma in the study period were identified and the available corresponding Pap smears (in preceding 1 year) were retrieved. In addition, the Pap smears reported as glandular cell abnormalities (GCA) during the same study period were retrieved. The overall prevalence of GCA, sensitivity, and specificity of Pap smears for the detection of GCA was calculated. The diagnostic accuracy of conventional and LBC smears for the diagnosis of GCA was also compared. Results: The prevalence of GCA in our study was 0.32%. The overall specificity of Pap smears for the diagnosis of GCA was 60.8%, this was not significantly different between conventional and LBC smears (P = 0.4). The overall sensitivity of Pap smears for the detection of GCA was 41.8%; LBC smears had significantly better sensitivity as compared to conventional smears for the detection of endometrial as compared to endocervical adenocarcinoma (P < 0.05). Conclusions: The prevalence of GCA in Pap smears is low. The specificity of Pap smears, for diagnosis of GCA, was found to be moderate. However, the overall sensitivity of Pap smears for the detection of GCA was low, though better for LBC as compared to conventional smears.
      Citation: CytoJournal 2016 13(1):3-3
      PubDate: Mon,22 Feb 2016
      DOI: 10.4103/1742-6413.177156
      Issue No: Vol. 13, No. 1 (2016)
       
  • Fine needle aspiration biopsy of metastatic malignant mesothelioma with
           myxoid change and signet ring cells: A case report and review of the
           literature

    • Authors: Manisha M Mishra, Carol F Farver, Deborah J Chute
      Pages: 4 - 4
      Abstract: Manisha M Mishra, Carol F Farver, Deborah J Chute
      CytoJournal 2016 13(1):4-4
      Malignant mesothelioma (MM) is a rare neoplasm, which is most commonly encountered in cytology through effusion specimens. Fine needle aspiration biopsy of MM, particularly the epithelioid subtype, can be a source of diagnostic difficulty and may mimic sampling of an adenocarcinoma. This is the first case report to demonstrate abundant extracellular myxoid material and numerous intracellular vacuoles, including signet ring cells, in a fine needle aspirate of metastatic MM. A review of the literature for myxoid change and vacuoles in fine needle aspiration biopsies of MM discloses that vacuoles are found in up to 35% of aspirates of MM, but myxoid change is very rare, reported in
      Citation: CytoJournal 2016 13(1):4-4
      PubDate: Mon,22 Feb 2016
      DOI: 10.4103/1742-6413.177157
      Issue No: Vol. 13, No. 1 (2016)
       
  • Cytopathological yarn of a suprasellar mass lesion: Diagnostic clues and
           pitfalls

    • Authors: GV Manjunath, CS Sheeladevi, Sunila, MC Sapna Patel, BN Kumarguru
      Pages: 5 - 5
      Abstract: GV Manjunath, CS Sheeladevi, Sunila , MC Sapna Patel, BN Kumarguru
      CytoJournal 2016 13(1):5-5

      Citation: CytoJournal 2016 13(1):5-5
      PubDate: Mon,22 Feb 2016
      DOI: 10.4103/1742-6413.177158
      Issue No: Vol. 13, No. 1 (2016)
       
  • Estimation of iron overloads using oral exfoliative cytology in
           beta-thalassemia major patients

    • Authors: Swati Leekha, Amit Kumar Nayar, Preeti Bakshi, Aman Sharma, Swati Parhar, Sugandhi Soni
      Pages: 6 - 6
      Abstract: Swati Leekha, Amit Kumar Nayar, Preeti Bakshi, Aman Sharma, Swati Parhar, Sugandhi Soni
      CytoJournal 2016 13(1):6-6
      Background: Iron overload is a medical condition that occurs when too much of the mineral iron builds up inside the body and produces a toxic reaction. Thalassemia is a genetic disorder of hemoglobin synthesis, which requires regular blood transfusion therapy, and the lack of specific excretory pathways for iron in humans leads to iron overload in the body tissues. It is a major cause of morbidity and mortality in these patients. The estimation of iron levels in exfoliated buccal mucosal cells may provide a simple, noninvasive, and a safe procedure for estimating the iron overload by using the Perls' Prussian blue stain. Methods: Smears were obtained from buccal mucosa of 40 randomly selected beta-thalassemia major patients and 40 healthy subjects as controls. Smears were stained with Perls' Prussian blue method. Blood samples were taken for estimation of serum ferritin levels. Images of smears were analyzed using the software image J software version 1.47v and correlated with serum ferritin. Results: Perls' positivity was observed in 87.5% of thalassemic patients with a positive correlation to serum ferritin levels. Conclusion: The use of exfoliative buccal mucosal cells for the evaluation of iron overloads in the body provides us with a diagnostic medium that is noninvasive, easy to collect, store, and transport, cost effective, and above all reliable.
      Citation: CytoJournal 2016 13(1):6-6
      PubDate: Fri,18 Mar 2016
      DOI: 10.4103/1742-6413.178993
      Issue No: Vol. 13, No. 1 (2016)
       
  • Clear cell neuroendocrine tumor of pancreas: Endoscopic Ultrasound-guided
           fine needle aspiration diagnosis of an uncommon variant

    • Authors: Gagandeep Kaur, Pooja Bakshi, Vikas Singla, Kusum Verma
      Pages: 7 - 7
      Abstract: Gagandeep Kaur, Pooja Bakshi, Vikas Singla, Kusum Verma
      CytoJournal 2016 13(1):7-7
      The cytomorphologic features of clear cell neuroendocrine tumor of pancreas have been rarely reported in cytology literature. The cytomorphology of this rare variant mimics many primary and metastatic clear cell tumors of the pancreas. However, a precise cytological diagnosis can be rendered by awareness of this entity and judicious use of immunohistochemistry. We report one such case in a young woman diagnosed on endoscopic ultrasound fine needle aspiration. The tumor cells showed positive staining with synaptophysin, chromogranin, and also with inhibin.
      Citation: CytoJournal 2016 13(1):7-7
      PubDate: Fri,18 Mar 2016
      DOI: 10.4103/1742-6413.178995
      Issue No: Vol. 13, No. 1 (2016)
       
  • Abdominal lymphadenopathy: An interesting and rare case diagnosed on
           endoscopic ultrasound-guided fine needle aspiration cytology

    • Authors: Ankita Grover, Gagandeep Kaur, Ashish Kumar, Varun Gupta, Pooja Bakshi, Sunila Jain, Anil Arora, Kusum Verma
      Pages: 8 - 8
      Abstract: Ankita Grover, Gagandeep Kaur, Ashish Kumar, Varun Gupta, Pooja Bakshi, Sunila Jain, Anil Arora, Kusum Verma
      CytoJournal 2016 13(1):8-8

      Citation: CytoJournal 2016 13(1):8-8
      PubDate: Fri,18 Mar 2016
      DOI: 10.4103/1742-6413.178997
      Issue No: Vol. 13, No. 1 (2016)
       
  • Sclerosing hemangioma: A diagnostic dilemma in fine needle aspiration
           cytology

    • Authors: Jennifer Zeng, Fang Zhou, Xiao-Jun Wei, Sandor Kovacs, Aylin Simsir, Yan Shi
      Pages: 9 - 9
      Abstract: Jennifer Zeng, Fang Zhou, Xiao-Jun Wei, Sandor Kovacs, Aylin Simsir, Yan Shi
      CytoJournal 2016 13(1):9-9
      Sclerosing hemangioma of the lung is a benign neoplasm with a widely debated histogenesis. It has a polymorphic histomorphology characterized by a biphasic cell population of "surface cells" and "round cells" arranged in four general patterns: Papillary, solid, angiomatous, and sclerotic. This variability in histomorphology makes it difficult to diagnose sclerosing hemangioma by fine needle aspiration (FNA). We present a case of sclerosing hemangioma diagnosed on FNA with immunohistochemistry performed on an accompanied cell block. The clinical presentation, cytomorphology, immunohistochemistry, and differential diagnoses are discussed.
      Citation: CytoJournal 2016 13(1):9-9
      PubDate: Wed,20 Apr 2016
      DOI: 10.4103/1742-6413.180783
      Issue No: Vol. 13, No. 1 (2016)
       
  • Cervical cytology as a diagnostic tool for female genital schistosomiasis:
           Correlation to cervical atypia and Schistosoma polymerase chain reaction

    • Authors: Pavitra Pillay, Lisette van Lieshout, Myra Taylor, Motshedisi Sebitloane, Siphosenkosi Gift Zulu, Elisabeth Kleppa, Borghild Roald, Eyrun Floerecke Kjetland
      Pages: 10 - 10
      Abstract: Pavitra Pillay, Lisette van Lieshout, Myra Taylor, Motshedisi Sebitloane, Siphosenkosi Gift Zulu, Elisabeth Kleppa, Borghild Roald, Eyrun Floerecke Kjetland
      CytoJournal 2016 13(1):10-10
      Background: Female genital schistosomiasis (FGS) is a tissue reaction to lodged ova of Schistosoma haematobium in the genital mucosa. Lesions can make the mucosa friable and prone to bleeding and discharge. Women with FGS may have an increased risk of HIV acquisition, and FGS may act as a cofactor in the development of cervical cancer. Objectives: To explore cytology as a method for diagnosing FGS and to discuss the diagnostic challenges in low-resource rural areas. The correlation between FGS and squamous cell atypia (SCA) is also explored and discussed. Cytology results are compared to Schistosoma polymerase chain reaction (PCR) in vaginal lavage and urine and in urine microscopy. Materials and Methods: In a clinical study, 394 women aged between 16 and 23 years from rural high schools in KwaZulu-Natal, South Africa, underwent structured interviews and the following laboratory tests: Cytology Papanicolaou (Pap) smears for S. haematobium ova and cervical SCA, real-time PCR for Schistosoma-specific DNA in vaginal lavage and urine samples, and urine microscopy for the presence of S. haematobium ova. Results: In Pap smears, S. haematobium ova were detected in 8/394 (2.0%). SCA was found in 107/394 (27.1%), seven of these had high-grade squamous intraepithelial lesion (HSIL). Schistosoma specific DNA was detected in 38/394 (9.6%) of vaginal lavages and in 91/394 (23.0%) of urines. Ova were found microscopically in 78/394 (19.7%) of urines. Conclusion: Schistosoma PCR on lavage was a better way to diagnose FGS compared to cytology. There was a significant association between S. haematobium ova in Pap smears and the other diagnostic methods. In low-resource Schistosoma-endemic areas, it is important that cytology screeners are aware of diagnostic challenges in the identification of schistosomiasis in addition to the cytological diagnosis of SCA. Importantly, in this study, three of eight urines were negative but showed Schistosoma ova in their Pap smear, and one of them was also negative for Schistosoma DNA in urine. In this study, SCA was not significantly associated with schistosomiasis. HSIL detected in this young population might need future consideration.
      Citation: CytoJournal 2016 13(1):10-10
      PubDate: Wed,20 Apr 2016
      DOI: 10.4103/1742-6413.180784
      Issue No: Vol. 13, No. 1 (2016)
       
  • The role of intraoperative scrape cytology in vertebroplasty

    • Authors: Renuka Venkata Inuganti, Rami Reddy Mettu, Harsha Vardhan Surath, Amarnath Surath
      Pages: 11 - 11
      Abstract: Renuka Venkata Inuganti, Rami Reddy Mettu, Harsha Vardhan Surath, Amarnath Surath
      CytoJournal 2016 13(1):11-11
      Aims: To assess the adequacy of intraoperative scrape cytology during percutaneous vertebroplasty by correlating results with corresponding histopathology. Settings and Design: Vertebroplasty is a procedure increasingly used to treat painful vertebral compression fractures. The history and presentation of osteoporotic fractures are straightforward, but difficulty arises in differentiating infective from neoplastic lesions, especially in cases where the magnetic resonance imaging is equivocal. The procedure involves injection of polymethyl methacrylate (bone cement) into the pathological vertebral body and gives dramatic pain relief. It is indicated in osteoporotic and neoplastic lesions but contraindicated in infections. Hence, intraoperative evaluation of a specimen is essential to aid in the decision of performing vertebroplasty. Subjects and Methods: A total of 128 patients with vertebral lesions underwent core biopsy and scrape cytology from June 2006 to June 2015. Based on the findings of cytological examination, malignant lesions were subjected to vertebroplasty. In lesions with infective etiology, vertebroplasty was abandoned and antibiotic or antituberculous therapy started. Results: The overall diagnostic accuracy of scrape cytology was excellent with 97.58% cases correlating with the final histopathological diagnosis. Specificity was 100%, positive predictive value was 100% and negative predictive value was 33.33%. Conclusion: Scrape cytology is a simple, rapid, accurate cytodiagnostic technique and should be routinely utilized in vertebral lesions for intraoperative consultation and decision making during vertebroplasty.
      Citation: CytoJournal 2016 13(1):11-11
      PubDate: Wed,25 May 2016
      DOI: 10.4103/1742-6413.182954
      Issue No: Vol. 13, No. 1 (2016)
       
  • Cytomorphological features of papillary cystadenocarcinoma of parotid
           gland: A case report with review of literature

    • Authors: Usha Joshi, Sanjay Singh Chufal, Naveen Thapliyal, Harsh Khetan
      Pages: 12 - 12
      Abstract: Usha Joshi, Sanjay Singh Chufal, Naveen Thapliyal, Harsh Khetan
      CytoJournal 2016 13(1):12-12
      Papillary cystadenocarcinoma is a very rare slow growing malignant neoplasm characterized by cysts and intraluminal papillary projections. It is defined by WHO as a separate entity. On FNA, cytological features can mimic with various papillary and cystic neoplasms of salivary gland. It is also difficult to distinguish from benign salivary gland neoplasms as it has bland nuclear features. Thus we present cytomorphological features and discuss its differential diagnosis with neoplasms having prominent papillary architecture with review of literature.
      Citation: CytoJournal 2016 13(1):12-12
      PubDate: Wed,25 May 2016
      DOI: 10.4103/1742-6413.182955
      Issue No: Vol. 13, No. 1 (2016)
       
  • Pleural fluid metastases of myoepithelial carcinoma: A case report and
           review of the literature

    • Authors: Alicia Calderon Bhambra, Yanhong Zhang, Eric C Huang, John Bishop, Mahan Matin, Alaa Afify
      Pages: 13 - 13
      Abstract: Alicia Calderon Bhambra, Yanhong Zhang, Eric C Huang, John Bishop, Mahan Matin, Alaa Afify
      CytoJournal 2016 13(1):13-13
      Myoepithelial carcinoma (MECA) is one of the rarest salivary gland neoplasms, which may either arise de novo or develop within a preexisting pleomorphic adenoma or benign myoepithelioma. The tumor occurs mainly in the parotid gland followed by minor salivary glands and other body sites. As a result of their morphologic heterogeneity, they can be confused easily with many tumors. Awareness of their unique cytoarchitectural patterns and immunohistochemical profile is crucial for accurate identification. Herein, we report a rare case of a 51-year-old female patient with MECA of the maxillary sinus that metastasized to the pleural fluid. To the best of our knowledge, this is the first case of pleural fluid involvement by MECA reported in the literature.
      Citation: CytoJournal 2016 13(1):13-13
      PubDate: Fri,10 Jun 2016
      DOI: 10.4103/1742-6413.183829
      Issue No: Vol. 13, No. 1 (2016)
       
  • Unsatisfactory rate in liquid-based cervical samples as compared to
           conventional smears: A study from tertiary care hospital

    • Authors: Nalini Gupta, Vikrant S Bhar, Arvind Rajwanshi, Vanita Suri
      Pages: 14 - 14
      Abstract: Nalini Gupta, Vikrant S Bhar, Arvind Rajwanshi, Vanita Suri
      CytoJournal 2016 13(1):14-14
      Background: Developed countries adopted liquid-based cytology (LBC) cervical cytology, partly because of its lower proportions of unsatisfactory (U/S)/inadequate samples. This study was carried out to evaluate effect on the rate of U/S samples after introduction of LBC in our laboratory. Materials and Methods: An audit of U/S cervical samples was performed, which included split samples (n = 1000), only conventional Pap smear (CPS) smears (n = 1000), and only LBC samples (n = 1000). The smears were reviewed by two observers independently, and adequacy for the samples was assessed as per The Bethesda System 2001. The reasons for U/S rate in split samples were categorized into various cytologic and/or technical reasons. Results: U/S rate was far less in only LBC samples (1.2%) as compared to only CPS (10.5%) cases. Cases in the satisfactory but limited category were also less in only LBC (0.4%) as compared to only CPS (3.2%) samples. The main reasons for U/S smears in split samples were low cell count (37.2% in CPS; 58.8% in LBC). The second main reason was low cellularity with excess blood and only excess blood in CPS samples. Conclusion: There was a significant reduction of U/S rate in LBC samples as compared to CPS samples, and the difference was statistically significant. The main cause of U/S samples in LBC was low cellularity indicating a technical fault in sample collection. The main cause of U/S rate in CPS was low cellularity followed by low cellularity with excess blood. Adequate training of sample takers and cytologists for the precise cell count to determine adequacy in smears can be of great help in reducing U/S rate.
      Citation: CytoJournal 2016 13(1):14-14
      PubDate: Fri,10 Jun 2016
      DOI: 10.4103/1742-6413.183831
      Issue No: Vol. 13, No. 1 (2016)
       
  • CytoJournal Quiz Cases: Publishing open-access, PubMed-searchable
           cytopathology cases with educational messages

    • Authors: Katherine G Akers, Vinod B Shidman
      Pages: 15 - 15
      Abstract: Katherine G Akers, Vinod B Shidman
      CytoJournal 2016 13(1):15-15

      Citation: CytoJournal 2016 13(1):15-15
      PubDate: Wed,27 Jul 2016
      DOI: 10.4103/1742-6413.187015
      Issue No: Vol. 13, No. 1 (2016)
       
  • Fine needle aspiration cytology of cervical lymph node involvement by
           ovarian serous borderline tumor

    • Authors: Longwen Chen, Kristina A Butler, Debra A Bell
      Pages: 16 - 16
      Abstract: Longwen Chen, Kristina A Butler, Debra A Bell
      CytoJournal 2016 13(1):16-16
      Serous borderline tumor (SBT) involving a cervical lymph node is extremely rare. In addition, fine needle aspiration (FNA) cytology of the involved cervical lymph node shares tremendous morphologic similarity with other low-grade papillary carcinomas. Thus, it can be easily misdiagnosed as metastatic carcinoma. A 42-year-old female had a history of bilateral SBT and postbilateral salpingo-oophorectomy. She presented with left cervical lymphadenopathy 6 months later. FNA cytology showed a low-grade papillary neoplasm with psammoma bodies. Needle core biopsy along with immunostains was diagnostic of cervical lymph node involvement (LNI) of SBT. although extremely rare, cervical LNI can be found in patients with SBTs. FNA cytology, sometimes, is indistinguishable from metastatic papillary adenocarcinoma. Cell block or needle core biopsy is essential to make the correct diagnosis.
      Citation: CytoJournal 2016 13(1):16-16
      PubDate: Wed,27 Jul 2016
      DOI: 10.4103/1742-6413.187052
      Issue No: Vol. 13, No. 1 (2016)
       
  • Tuberculous lymphadenitis: Comparison of cytomorphology, Ziehl-Neelsen
           staining, and rapid mycobacterial culture at a pediatric superspecialty
           hospital

    • Authors: Sonam Mahana, Reena Tomar, Rawi Agrawal, Rushika Saksena, Vikas Manchanda, Ruchika Gupta
      Pages: 17 - 17
      Abstract: Sonam Mahana, Reena Tomar, Rawi Agrawal, Rushika Saksena, Vikas Manchanda, Ruchika Gupta
      CytoJournal 2016 13(1):17-17
      Background: To evaluate and compare the role of Ziehl-Neelsen (ZN) staining and mycobacterial culture in diagnosis of tuberculous lymphadenitis. Materials and Methods: A total of 56 fine needle aspirations (FNAs) from patients who were clinically suspected to have tuberculous lymphadenitis were included. Acid-fast Bacilli detection was attempted by ZN staining on smears as well as culture on Middlebrook 7H9 broth. Percentage positivity of both smears and culture was calculated. Results: Of the 56 cases, 46 showed cytomorphological features consistent with tuberculosis (TB). The most common pattern was only necrosis in 37 cases followed by necrotizing granulomas in 13 cases. ZN-stained smears were positive in 40 cases while culture was positive in only 27 cases. The highest smear and culture positivity was noted in cases with only necrosis. In six cases, diagnosis of TB was made on culture alone since smear was negative in these cases. Conclusion: FNA is a reliable technique for early and accurate diagnosis of tuberculous lymphadenitis in many cases. Mycobacterial culture by newer rapid techniques can assist in bacillary detection in smear-negative cases and also allows for drug sensitivity testing. Hence, culture should be resorted to in such cases.
      Citation: CytoJournal 2016 13(1):17-17
      PubDate: Wed,27 Jul 2016
      DOI: 10.4103/1742-6413.187070
      Issue No: Vol. 13, No. 1 (2016)
       
  • Fine-needle aspiration and core biopsy in the diagnosis of breast lesions:
           A comparison and review of the literature

    • Authors: Suvradeep Mitra, Pranab Dey
      Pages: 18 - 18
      Abstract: Suvradeep Mitra, Pranab Dey
      CytoJournal 2016 13(1):18-18
      In recent times, the diagnosis of breast lesions has mostly become dependent on core needle biopsies (CNBs) with a gradual reduction in the rate of performing fine-needle aspiration cytology (FNAC). Both the procedures have their pros and cons and outsmart each other taking into account different parameters. Both the methods are found to be fraught with loopholes, taking into account different performance indices, diagnostic accuracy and concordance, patient benefit, and cost-effectiveness. Unlike the popular belief of an absolute superiority of CNB over FNAC, the literature review does not reveal a very distinct demarcation in many aspects. We recommend judicious use of these diagnostic modalities in resource-limited settings and screening programs taking into account parameters such as palpability and availability of an experienced cytopathologist.
      Citation: CytoJournal 2016 13(1):18-18
      PubDate: Wed,31 Aug 2016
      DOI: 10.4103/1742-6413.189637
      Issue No: Vol. 13, No. 1 (2016)
       
  • Diagnostic relevance of cell block procedure in secondary tumors of the
           pancreas

    • Authors: Antonio Ieni, Valeria Barresi, Giovanni Tuccari
      Pages: 19 - 19
      Abstract: Antonio Ieni, Valeria Barresi, Giovanni Tuccari
      CytoJournal 2016 13(1):19-19

      Citation: CytoJournal 2016 13(1):19-19
      PubDate: Wed,31 Aug 2016
      DOI: 10.4103/1742-6413.189638
      Issue No: Vol. 13, No. 1 (2016)
       
  • Stromal tissue as an adjunct tool in the diagnosis of follicular thyroid
           lesions by fine-needle aspiration biopsy

    • Authors: Kien T Mai, Kevin Hogan
      Pages: 20 - 20
      Abstract: Kien T Mai, Kevin Hogan
      CytoJournal 2016 13(1):20-20
      Background: The stroma in fine-needle aspiration biopsy (FNAB) of thyroid lesions has not been well investigated. Design : We studied 256 consecutive cases of thyroid FNAB prepared with traditional smear technique. The stroma was categorized: Type 1a consisted of long (more than 3 mm), broad bands composed of mesh containing collagen fibrils thickened by entrapped blood components and follicular cells. Type 1b consisted of dense strands/bands. Type 2 was similar to Type 1a but with shorter (
      Citation: CytoJournal 2016 13(1):20-20
      PubDate: Wed,31 Aug 2016
      DOI: 10.4103/1742-6413.189639
      Issue No: Vol. 13, No. 1 (2016)
       
  • A case of S-100 negative melanoma: A diagnostic pitfall in the workup of a
           poorly differentiated metastatic tumor of unknown origin

    • Authors: Anna Biernacka, Konstantinos D Linos, Peter A DeLong, Arief A Suriawinata, Vijayalakshmi Padmanabhan, Xiaoying Liu
      Pages: 21 - 21
      Abstract: Anna Biernacka, Konstantinos D Linos, Peter A DeLong, Arief A Suriawinata, Vijayalakshmi Padmanabhan, Xiaoying Liu
      CytoJournal 2016 13(1):21-21
      When confronted with a metastatic poorly differentiated tumor of unknown origin, the initial workup includes the standard panel of immunostains to rule out carcinoma, sarcoma, lymphoma, and the greatest mimicker in pathology - malignant melanoma. Although not specific, the S-100 protein is expressed in over 95% of malignant melanomas. Herein, we present a case of multiorgan metastatic malignancy with a dominant hilar and mediastinal mass in a current smoker; clinically, highly suggestive of widespread primary lung cancer. This case was eventually classified as malignant melanoma, despite a significant diagnostic challenge due to lack of prior history, unusual cytomorphology, and S-100 protein negativity. A battery of immunostains was performed and the addition of other melanocytic-associated markers confirmed the melanocytic lineage of the neoplasm. This case highlights the pitfalls in the differential diagnosis of a metastatic tumor of unknown origin by fine needle aspiration cytology due to the significant morphologic overlap of poorly differentiated malignancies. We emphasize that, albeit rare, malignant melanomas can be completely negative for S-100 protein and the use of additional melanocytic-associated markers in the differential workup maybe critical in arriving promptly at a proper diagnosis. We also briefly discuss other currently available immunohistochemical markers that can assist in the identification of the S-100 negative melanoma.
      Citation: CytoJournal 2016 13(1):21-21
      PubDate: Tue,20 Sep 2016
      DOI: 10.4103/1742-6413.190914
      Issue No: Vol. 13, No. 1 (2016)
       
  • Prognostic markers in smear preparations for pancreatic endocrine
           neoplasms: A cytomorphologic study and statistical analysis of 20
           potential prognostic features

    • Authors: Lester J Layfield, Robert L Schmidt, Jack Campbell, Magda Esebua
      Pages: 22 - 22
      Abstract: Lester J Layfield, Robert L Schmidt, Jack Campbell, Magda Esebua
      CytoJournal 2016 13(1):22-22
      Background: Papanicolaou Society of Cytopathology guidelines place low- and intermediate-grade pancreatic endocrine tumors into the "neoplastic, other" category whereas high-grade pancreatic endocrine tumors are placed in the "malignant" category. No attempt was made to stratify pancreatic endocrine tumors in the "neoplastic, other" category by likelihood for metastases. Histologically, pancreatic endocrine tumors are divided into well, intermediate, and poorly differentiated examples based on mitotic count and Ki-67 proliferation index (PI). PI has been used in the evaluation of cytologic specimens utilizing cell block material. Unfortunately, cell block material may not always be available for analysis, and little data exists as to cytomorphologic features in smear preparations which might distinguish between low- and intermediate-grade endocrine neoplasms and predict metastases. Methods: We studied 36 cases of Diff-Quik stained smear preparations for 20 morphologic features to determine which best-classified cases into poor and not poor outcome categories. Hierarchical logistic regression analysis was used to determine associations between the morphologic features and outcomes. Results: Absolute agreement between raters ranged from 51% to 97% across the 20 morphologic features. About 12 of the 20 morphologic features showed statistically significant associations with poor outcome. Mitoses, irregular nuclear membranes, and 3-fold variation in nuclear size are the best discriminators between poor and not poor outcomes. Conclusions: A scoring system was developed utilizing mitoses, irregular nuclear membranes, and 3-fold variation in nuclear size to divide smears of pancreatic endocrine tumors into poor and not poor outcome groups. The scoring system achieved 84% accuracy in separating cases into poor and not poor outcomes.
      Citation: CytoJournal 2016 13(1):22-22
      PubDate: Tue,20 Sep 2016
      DOI: 10.4103/1742-6413.190915
      Issue No: Vol. 13, No. 1 (2016)
       
  • Oncocytic variant of poorly differentiated thyroid carcinoma: "Is
           diagnosis possible by fine-needle aspiration?"

    • Authors: Mine Onenerk, Sule Canberk, Pembegul Gunes, Murat Erkan, Gamze Z Kilicoglu
      Pages: 23 - 23
      Abstract: Mine Onenerk, Sule Canberk, Pembegul Gunes, Murat Erkan, Gamze Z Kilicoglu
      CytoJournal 2016 13(1):23-23
      Poorly differentiated thyroid carcinoma (PDTC) is a very rare entity, and the diagnosis can be made on histopathology specimens. However, recognition of characteristic features of PDTC is significant on fine-needle aspirations (FNAs) to differentiate this entity from well-differentiated and anaplastic thyroid carcinomas. Here, we present an FNA case concordant with "oncocytic variant of PDTC" and discuss whether definitive diagnosis can be given on FNAs to assess the prognosis in clinically inoperable patients.
      Citation: CytoJournal 2016 13(1):23-23
      PubDate: Thu,13 Oct 2016
      DOI: 10.4103/1742-6413.192188
      Issue No: Vol. 13, No. 1 (2016)
       
  • Endoscopic ultrasound-guided fine needle aspiration cytology of metastatic
           renal cell carcinoma to the pancreas: A multi-center experience

    • Authors: Rahul Pannala, Karyn M Hallberg-Wallace, Amber L Smith, Aziza Nassar, Jun Zhang, Matthew Zarka, Jordan P Reynolds, Longwen Chen
      Pages: 24 - 24
      Abstract: Rahul Pannala, Karyn M Hallberg-Wallace, Amber L Smith, Aziza Nassar, Jun Zhang, Matthew Zarka, Jordan P Reynolds, Longwen Chen
      CytoJournal 2016 13(1):24-24
      Introduction: The increasing use of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) cytology to examine pancreatic neoplasms has led to an increase in the diagnosis of metastases to the pancreas. Renal cell carcinoma (RCC) is the most common metastasis to the pancreas. Our study examines 33 cases of metastatic RCC to the pancreas sampled by EUS-FNA from four large tertiary care hospitals. Materials and Methods: We searched the cytopathology database for RCC metastatic to the pancreas diagnosed by EUS-FNA from January 2005 to January 2015. Patient age, history of RCC, nephrectomy history, follow-up postnephrectomy, radiological impression, and EUS-FNA cytologic diagnosis were reviewed. Results: Thirty-three patients were identified. The average age was 67.5 years (range, 49-84 years). Thirty-two patients had a previous documented history of RCC. One patient had the diagnosis of pancreatic metastasis at the same time of the kidney biopsy. Thirty-one patients had been treated with nephrectomy. Twenty-seven patients were being monitored annually by computed tomography or magnetic resonance imaging. Twenty-five patients had multiple masses by imaging, but 8 patients had a single mass in the pancreas at the time of EUS-FNA. EUS-FNA of 20 cases showed classic morphology of RCC. Thirteen cases had either "atypical" clinical-radiologic features or morphologic overlaps with primary pancreatic neoplasms or other neoplasms. Cell blocks were made on all 13 cases and immunochemical stains confirmed the diagnosis. Conclusions: EUS-FNA cytology is useful for the diagnosis of metastatic RCC to the pancreas. Cytomorphology can be aided with patient history, imaging analyses, cell blocks, and immunochemical stains.
      Citation: CytoJournal 2016 13(1):24-24
      PubDate: Thu,13 Oct 2016
      DOI: 10.4103/1742-6413.192191
      Issue No: Vol. 13, No. 1 (2016)
       
  • Erratum: CytoJournal Quiz Cases: Publishing open access, PubMed searchable
           cytopathology cases with educational messages.

    • Pages: 25 - 25
      Abstract:
      CytoJournal 2016 13(1):25-25

      Citation: CytoJournal 2016 13(1):25-25
      PubDate: Thu,13 Oct 2016
      DOI: 10.4103/1742-6413.192192
      Issue No: Vol. 13, No. 1 (2016)
       
  • Diagnostic utility of double immunostaining of a urine cytology
           preparation for cytokeratin 20/p53 expression in a young woman with
           micropapillary urothelial carcinoma of the renal pelvis presenting as an
           unknown primary malignancy

    • Authors: Hyun-Jung Kim, Lucky Sung, Jung-Yeon Kim, Kyeongmee Park
      Pages: 26 - 26
      Abstract: Hyun-Jung Kim, Lucky Sung, Jung-Yeon Kim, Kyeongmee Park
      CytoJournal 2016 13(1):26-26
      Atypical urine cytology (CYT) triggers a cystoscopic or another ancillary investigation that targets urothelial neoplasms. We report a case presenting as an unknown primary malignancy, which illustrated the diagnostic utility of direct double immunostaining for cytokeratin 20 (CK20)/p53 expression in a urine CYT specimen. A 42-year-old woman visited the emergency room for pain in her right lower abdominal quadrant. Computed tomography revealed postrenal obstructive hydronephrosis, and her urine CYT showed malignancy, type undetermined. Atypical cells that are positive for cytoplasmic expression of CK20 and nuclear expression of p53 could facilitate the decision to perform a nephroureterectomy for urothelial carcinoma.
      Citation: CytoJournal 2016 13(1):26-26
      PubDate: Wed,16 Nov 2016
      DOI: 10.4103/1742-6413.194162
      Issue No: Vol. 13, No. 1 (2016)
       
  • The effect of the small amount of formaldehyde in the SurePath liquid when
           establishing protocols for immunocytochemistry

    • Authors: Ellen Cathrine Bjonness-Jacobsen, Anne Kristine Kallevag Eriksen, Vidar Nylokken Hagen, Kirsten Margrethe Ostbye, Anna Witterso, Mette Kristin Pedersen, Torill Sauer
      Pages: 27 - 27
      Abstract: Ellen Cathrine Bjonness-Jacobsen, Anne Kristine Kallevag Eriksen, Vidar Nylokken Hagen, Kirsten Margrethe Ostbye, Anna Witterso, Mette Kristin Pedersen, Torill Sauer
      CytoJournal 2016 13(1):27-27
      Background: SurePath® is an ethanol-based liquid fixative. In addition to ethanol, it also contains a small amount of formaldehyde (
      Citation: CytoJournal 2016 13(1):27-27
      PubDate: Wed,16 Nov 2016
      DOI: 10.4103/1742-6413.194163
      Issue No: Vol. 13, No. 1 (2016)
       
  • Detection of in situ and invasive endocervical adenocarcinoma on ThinPrep
           Pap Test: Morphologic analysis of false negative cases

    • Authors: Michael Chaump, Edyta C Pirog, Vinicius J. A. Panico, Alexandre Buckley d Meritens, Kevin Holcomb, Rana Hoda
      Pages: 28 - 28
      Abstract: Michael Chaump, Edyta C Pirog, Vinicius J. A. Panico, Alexandre Buckley d Meritens, Kevin Holcomb, Rana Hoda
      CytoJournal 2016 13(1):28-28
      Background: The goal of this study was to calculate the sensitivity and false negative (FN) rate of ThinPrep Pap Test (TPPT) and carefully analyze missed cases for educational purposes. Materials and Methods: Patients with histologically proven adenocarcinoma in-situ (AIS) or invasive endocervical adenocarcinoma (EAC) over a 17-year-period (1998-2015) were identified. The TPPT immediately preceding the histological diagnosis of AIS/ECA was designated as index Pap (IP). Paps up to 122 months before histologic diagnosis of AIS/ECA were considered for this study. All available negative and unsatisfactory TPPT were re-reviewed. Results: There were 78 patients with histologically-proven AIS (56) or ECA (22) with 184 TPPTs, and 95 of these TPPTs were abnormal. Of the abnormal cases, 55.7% TPPTs were diagnosed as endocervical cell abnormality (atypical endocervical cells/AIS/ECA). Notably, 44.2% of abnormal TPPTs were diagnosed as squamous cell abnormality (atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion/high grade squamous intraepithelial lesion). Including the diagnoses of squamous cell abnormality, the sensitivity of index TPPT for histologically-confirmed AIS/ECA was 88%. Eighty-eight of 184 TPPT, including 10 IP, were negative = 87, or unsatisfactory = 1. Forty-two of these slides were available for re-review. Upon review, 21 TPPT (50%) were confirmed negative and 21 TPPT (50%) were reclassified as abnormal = 20, or unsatisfactory = 1. Of the FN cases, the main difficulty in correct diagnosis was the presence of few diagnostic cell clusters which had less "feathering," and consisted of smaller, rounder cells in small and tighter clusters, with nuclear overlap. In particular, nuclear overlap in three-dimensional groups precluded the accurate diagnosis. Rare FN cases showed squamous cell abnormality on re-review, and rare cases showed obscuring blood or inflammation. Conclusion: A significant proportion of AIS/EAC is discovered after Pap showing squamous cell abnormality. FN cases were most commonly related to nuclear overlap in tight three-dimensional clusters.
      Citation: CytoJournal 2016 13(1):28-28
      PubDate: Tue,20 Dec 2016
      DOI: 10.4103/1742-6413.196237
      Issue No: Vol. 13, No. 1 (2016)
       
  • An unexpected diagnosis of ectopic liver diagnosed by fine needle
           aspiration

    • Authors: Gonzalo Barazza, Douglas G Adler, Rachel E Factor
      Pages: 29 - 29
      Abstract: Gonzalo Barazza, Douglas G Adler, Rachel E Factor
      CytoJournal 2016 13(1):29-29
      The differential diagnosis of perigastric masses is broad, ranging from benign to malignant entities. Among the benign entities, accessory liver lobes and ectopic liver are unusual and often incidentally discovered. Here, we report a patient with malignant melanoma who was clinically suspected to have a perigastric metastasis or a gastrointestinal stromal tumor but was ultimately diagnosed by fine needle aspiration (FNA) to have benign ectopic liver. A 47-year-old male was diagnosed with malignant melanoma of the scalp in May 2015 at a tertiary care hospital. He was found to have a 2.6 cm enhancing mass adjacent to the fundus of the stomach and below the diaphragm by computed tomography imaging. To exclude metastasis, the patient was referred to endoscopy, and an endoscopic ultrasound-guided FNA was performed with rapid on-site evaluation (ROSE) by a cytopathologist. A relatively new FNA needle (Shark Core) was used, which produced useful core biopsy material. Cytopathology demonstrated flat sheets, single cells, and small clusters of polygonal cells. There was abundant granular cytoplasm, often containing pigment. Cells lacked pleomorphism. The smear findings appeared consistent with hepatocytes. The cell block demonstrated small core fragments of hepatic parenchyma with portal tracts. Immunohistochemistry for arginase-1 confirmed that this was hepatic tissue. ROSE was useful for communicating with the endoscopist that the mass was both far from, and not connected to, the liver. This is the first documented account of perigastric ectopic liver diagnosed by FNA. This entity should be considered in the differential of perigastric masses.
      Citation: CytoJournal 2016 13(1):29-29
      PubDate: Tue,20 Dec 2016
      DOI: 10.4103/1742-6413.196239
      Issue No: Vol. 13, No. 1 (2016)
       
 
 
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