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Publisher: Medknow Publishers   (Total: 355 journals)

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Showing 1 - 200 of 355 Journals sorted alphabetically
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advances in Human Biology     Open Access   (Followers: 1)
African J. for Infertility and Assisted Conception     Open Access  
African J. of Business Ethics     Open Access   (Followers: 6)
African J. of Medical and Health Sciences     Open Access   (Followers: 1)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.269, h-index: 10)
African J. of Trauma     Open Access  
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 6)
Anesthesia : Essays and Researches     Open Access   (Followers: 7)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.331, h-index: 15)
Annals of Bioanthropology     Open Access   (Followers: 3)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 12, SJR: 0.408, h-index: 15)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.308, h-index: 14)
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 7, SJR: 0.441, h-index: 10)
Annals of Saudi Medicine     Open Access   (SJR: 0.24, h-index: 29)
Annals of Thoracic Medicine     Open Access   (Followers: 4, SJR: 0.388, h-index: 19)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 15, SJR: 0.148, h-index: 5)
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Intl. Surgery     Open Access   (Followers: 9)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Pharmacy Practice     Open Access   (Followers: 5)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 3)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.879, h-index: 49)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 2, SJR: 0.362, h-index: 10)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Cancer Translational Medicine     Open Access   (Followers: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 1)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access   (Followers: 1)
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 12, SJR: 0.82, h-index: 12)
Contemporary Clinical Dentistry     Open Access   (Followers: 4)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.339, h-index: 19)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.131, h-index: 4)
Dental Research J.     Open Access   (Followers: 9)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 5, SJR: 0.205, h-index: 22)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access  
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.121, h-index: 3)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access  
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Orthopaedic J.     Open Access  
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.473, h-index: 8)
Environmental Disease     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.496, h-index: 11)
European J. of General Dentistry     Open Access   (Followers: 1)
European J. of Prosthodontics     Open Access   (Followers: 2)
European J. of Psychology and Educational Studies     Open Access   (Followers: 7)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.107, h-index: 5)
Genome Integrity     Open Access   (Followers: 4, SJR: 1.227, h-index: 12)
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
IJS Short Reports     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 8, SJR: 0.302, h-index: 13)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (SJR: 0.318, h-index: 26)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.618, h-index: 16)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.307, h-index: 16)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.243, h-index: 24)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.448, h-index: 16)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 3, SJR: 0.563, h-index: 29)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.292, h-index: 9)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.53, h-index: 34)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.716, h-index: 60)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.207, h-index: 31)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 1, SJR: 0.233, h-index: 12)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.213, h-index: 5)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 4, SJR: 0.203, h-index: 13)
Indian J. of Ophthalmology     Open Access   (Followers: 5, SJR: 0.536, h-index: 34)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 9, SJR: 0.393, h-index: 15)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.218, h-index: 5)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.35, h-index: 12)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 1, SJR: 0.285, h-index: 22)
Indian J. of Pharmacology     Open Access   (SJR: 0.347, h-index: 44)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.303, h-index: 13)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.496, h-index: 15)
Indian J. of Psychological Medicine     Open Access   (Followers: 1, SJR: 0.344, h-index: 9)
Indian J. of Public Health     Open Access   (Followers: 1, SJR: 0.444, h-index: 17)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4, SJR: 0.253, h-index: 14)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.169, h-index: 7)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.313, h-index: 9)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.366, h-index: 16)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 3)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 4, SJR: 0.229, h-index: 13)
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 2)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 7)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.239, h-index: 4)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.523, h-index: 15)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 7, SJR: 0.611, h-index: 9)
Intl. J. of Trichology     Open Access   (SJR: 0.37, h-index: 10)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 2)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 4, SJR: 0.427, h-index: 15)
J. of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 8, SJR: 0.416, h-index: 14)
J. of Applied Hematology     Open Access  
J. of Association of Chest Physicians     Open Access   (Followers: 2)
J. of Basic and Clinical Reproductive Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Therapeutics     Open Access   (Followers: 4, SJR: 0.359, h-index: 21)
J. of Carcinogenesis     Open Access   (Followers: 1, SJR: 1.152, h-index: 26)
J. of Cardiothoracic Trauma     Open Access  
J. of Cardiovascular Disease Research     Open Access   (Followers: 3, SJR: 0.351, h-index: 13)
J. of Cardiovascular Echography     Open Access   (SJR: 0.134, h-index: 2)
J. of Cleft Lip Palate and Craniofacial Anomalies     Open Access   (Followers: 2)
J. of Clinical and Preventive Cardiology     Open Access   (Followers: 1)
J. of Clinical Imaging Science     Open Access   (Followers: 1, SJR: 0.277, h-index: 8)
J. of Clinical Neonatology     Open Access   (Followers: 1)
J. of Clinical Ophthalmology and Research     Open Access   (Followers: 2)
J. of Clinical Sciences     Open Access  
J. of Conservative Dentistry     Open Access   (Followers: 4, SJR: 0.532, h-index: 10)
J. of Craniovertebral Junction and Spine     Open Access   (Followers: 4, SJR: 0.199, h-index: 9)
J. of Current Medical Research and Practice     Open Access  
J. of Current Research in Scientific Medicine     Open Access  
J. of Cutaneous and Aesthetic Surgery     Open Access   (Followers: 1)
J. of Cytology     Open Access   (Followers: 1, SJR: 0.274, h-index: 9)
J. of Dental and Allied Sciences     Open Access   (Followers: 1)
J. of Dental Implants     Open Access   (Followers: 7)
J. of Dental Lasers     Open Access   (Followers: 2)
J. of Dental Research and Review     Open Access   (Followers: 1)
J. of Digestive Endoscopy     Open Access   (Followers: 3)
J. of Dr. NTR University of Health Sciences     Open Access  
J. of Earth, Environment and Health Sciences     Open Access   (Followers: 1)
J. of Education and Ethics in Dentistry     Open Access   (Followers: 5)
J. of Education and Health Promotion     Open Access   (Followers: 5)
J. of Emergencies, Trauma and Shock     Open Access   (Followers: 9, SJR: 0.353, h-index: 14)
J. of Engineering and Technology     Open Access   (Followers: 6)
J. of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
J. of Family and Community Medicine     Open Access   (Followers: 2)
J. of Family Medicine and Primary Care     Open Access   (Followers: 9)

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Journal Cover Indian Journal of Dermatology
  [SJR: 0.448]   [H-I: 16]   [2 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 0019-5154
   Published by Medknow Publishers Homepage  [355 journals]
  • Indian Journal of Dermatology (IJD®) gets its first impact
           factor of 1.069

    • Authors: Koushik Lahiri
      Pages: 329 - 331
      Abstract: Koushik Lahiri
      Indian Journal of Dermatology 2017 62(4):329-331

      Citation: Indian Journal of Dermatology 2017 62(4):329-331
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_314_17
      Issue No: Vol. 62, No. 4 (2017)
       
  • Mycetoma: An update

    • Authors: Vineet Relhan, Khushbu Mahajan, Pooja Agarwal, Vijay Kumar Garg
      Pages: 332 - 340
      Abstract: Vineet Relhan, Khushbu Mahajan, Pooja Agarwal, Vijay Kumar Garg
      Indian Journal of Dermatology 2017 62(4):332-340
      Mycetoma is a localized chronic, suppurative, and deforming granulomatous infection seen in tropical and subtropical areas. It is a disorder of subcutaneous tissue, skin and bones, mainly of feet, characterized by a triad of localized swelling, underlying sinus tracts, and production of grains or granules. Etiological classification divides it into eumycetoma caused by fungus, and actinomycetoma caused by bacteria. Since the treatment of these two etiologies is entirely different, a definite diagnosis after histopathological and microbiological examination is mandatory, though difficult. Serological test exists but is not so reliable; however, molecular techniques to identify relevant antigens have shown promise. The disease is notoriously difficult to treat. Eumycetoma may be unresponsive to standard antifungal therapy. Actinomycetoma responds to antibiotic therapy, but prolonged treatment is necessary.This review focuses on the etiopathogenesis, clinical features, laboratory diagnosis, and treatment of mycetoma.
      Citation: Indian Journal of Dermatology 2017 62(4):332-340
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_476_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Synchronizing pharmacotherapy in acne with review of clinical care

    • Authors: Sarvajnamurthy Aradhya Sacchidanand, Koushik Lahiri, Kiran Godse, Narendra Gajanan Patwardhan, Anil Ganjoo, Rajendra Kharkar, Varsha Narayanan, Dhammraj Borade, Lyndon D'souza
      Pages: 341 - 357
      Abstract: Sarvajnamurthy Aradhya Sacchidanand, Koushik Lahiri, Kiran Godse, Narendra Gajanan Patwardhan, Anil Ganjoo, Rajendra Kharkar, Varsha Narayanan, Dhammraj Borade, Lyndon D'souza
      Indian Journal of Dermatology 2017 62(4):341-357
      Acne is a chronic inflammatory skin disease that involves the pathogenesis of four major factors, such as androgen-induced increased sebum secretion, altered keratinization, colonization of Propionibacterium acnes, and inflammation. Several acne mono-treatment and combination treatment regimens are available and prescribed in the Indian market, ranging from retinoids, benzoyl peroxide (BPO), anti-infectives, and other miscellaneous agents. Although standard guidelines and recommendations overview the management of mild, moderate, and severe acne, relevance and positioning of each category of pharmacotherapy available in Indian market are still unexplained. The present article discusses the available topical and oral acne therapies and the challenges associated with the overall management of acne in India and suggestions and recommendations by the Indian dermatologists. The experts opined that among topical therapies, the combination therapies are preferred over monotherapy due to associated lower efficacy, poor tolerability, safety issues, adverse effects, and emerging bacterial resistance. Retinoids are preferred in comedonal acne and as maintenance therapy. In case of poor response, combination therapies BPO-retinoid or retinoid-antibacterials in papulopustular acne and retinoid-BPO or BPO-antibacterials in pustular-nodular acne are recommended. Oral agents are generally recommended for severe acne. Low-dose retinoids are economical and have better patient acceptance. Antibiotics should be prescribed till the inflammation is clinically visible. Antiandrogen therapy should be given to women with high androgen levels and are added to regimen to regularize the menstrual cycle. In late-onset hyperandrogenism, oral corticosteroids should be used. The experts recommended that an early initiation of therapy is directly proportional to effective therapeutic outcomes and prevent complications.
      Citation: Indian Journal of Dermatology 2017 62(4):341-357
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_41_17
      Issue No: Vol. 62, No. 4 (2017)
       
  • Biostatistics series module 10: Brief overview of multivariate methods

    • Authors: Avijit Hazra, Nithya Gogtay
      Pages: 358 - 366
      Abstract: Avijit Hazra, Nithya Gogtay
      Indian Journal of Dermatology 2017 62(4):358-366
      Multivariate analysis refers to statistical techniques that simultaneously look at three or more variables in relation to the subjects under investigation with the aim of identifying or clarifying the relationships between them. These techniques have been broadly classified as dependence techniques, which explore the relationship between one or more dependent variables and their independent predictors, and interdependence techniques, that make no such distinction but treat all variables equally in a search for underlying relationships. Multiple linear regression models a situation where a single numerical dependent variable is to be predicted from multiple numerical independent variables. Logistic regression is used when the outcome variable is dichotomous in nature. The log-linear technique models count type of data and can be used to analyze cross-tabulations where more than two variables are included. Analysis of covariance is an extension of analysis of variance (ANOVA), in which an additional independent variable of interest, the covariate, is brought into the analysis. It tries to examine whether a difference persists after “controlling” for the effect of the covariate that can impact the numerical dependent variable of interest. Multivariate analysis of variance (MANOVA) is a multivariate extension of ANOVA used when multiple numerical dependent variables have to be incorporated in the analysis. Interdependence techniques are more commonly applied to psychometrics, social sciences and market research. Exploratory factor analysis and principal component analysis are related techniques that seek to extract from a larger number of metric variables, a smaller number of composite factors or components, which are linearly related to the original variables. Cluster analysis aims to identify, in a large number of cases, relatively homogeneous groups called clusters, without prior information about the groups. The calculation intensive nature of multivariate analysis has so far precluded most researchers from using these techniques routinely. The situation is now changing with wider availability, and increasing sophistication of statistical software and researchers should no longer shy away from exploring the applications of multivariate methods to real-life data sets.
      Citation: Indian Journal of Dermatology 2017 62(4):358-366
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_296_17
      Issue No: Vol. 62, No. 4 (2017)
       
  • Methodology series module 10: Qualitative health research

    • Authors: Maninder Singh Setia
      Pages: 367 - 370
      Abstract: Maninder Singh Setia
      Indian Journal of Dermatology 2017 62(4):367-370
      Although quantitative designs are commonly used in clinical research, some studies require qualitative methods. These designs are different from quantitative methods; thus, researchers should be aware of data collection methods and analyses for qualitative research. Qualitative methods are particularly useful to understand patient experiences with the treatment or new methods of management or to explore issues in detail. These methods are useful in social and behavioral research. In qualitative research, often, the main focus is to understand the issue in detail rather than generalizability; thus, the sampling methods commonly used are purposive sampling; quota sampling; and snowball sampling (for hard to reach groups). Data can be collected using in-depth interviews (IDIs) or focus group discussions (FGDs). IDI is a one-to-one interview with the participant. FGD is a method of group interview or discussion, in which more than one participant is interviewed at the same time and is usually led by a facilitator. The commonly used methods for data analysis are: thematic analysis; grounded theory analysis; and framework analysis. Qualitative data collection and analysis require special expertise. Hence, if the reader plans to conduct qualitative research, they should team up with a qualitative researcher.
      Citation: Indian Journal of Dermatology 2017 62(4):367-370
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_290_17
      Issue No: Vol. 62, No. 4 (2017)
       
  • Ethical issues pertinent to current clinical research environment in India

    • Authors: Nilay Kanti Das
      Pages: 371 - 372
      Abstract: Nilay Kanti Das
      Indian Journal of Dermatology 2017 62(4):371-372

      Citation: Indian Journal of Dermatology 2017 62(4):371-372
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_270_17
      Issue No: Vol. 62, No. 4 (2017)
       
  • Evolution of ethics in clinical research and ethics committee

    • Authors: Nilay Kanti Das, Amrita Sil
      Pages: 373 - 379
      Abstract: Nilay Kanti Das, Amrita Sil
      Indian Journal of Dermatology 2017 62(4):373-379
      Ethics are the moral values of human behavior and the principles which govern these values. The situation becomes challenging for a doctor when he assumes the role of researcher. The doctor-researcher has to serve both the roles and at times the zeal of an investigator has the potential to cloud the morality of the physician inside. It is very important to realize that exploiting the faith of patients is an offence that tantamount to a crime. Medical science is one discipline where the advancement of knowledge is hugely guided by research and mankind has benefitted from many experiments. However benefit and risk are the two faces of the same coin. Various unethical human experiments made us realize that the whims of researchers need to be reined and led to the evolution of the first guidelines for researcher, the Nuremberg code. Thereafter the Good Clinical Practice guidelines serve as the guiding doctrine of clinical research. The principles of ethics rest on the four pillars of autonomy, beneficence, justice, non-maleficence and recently two more pillars are added which includes, confidentiality and honesty. Ethics committees serve as a guardian of these principles. The multidisciplinary Ethics Committee ensures a competent review of the ethical aspects of the project proposal submitted and does it free from any bias or external influence. Ethical review of clinical trial applications follows a decentralized process in India, and requires Ethics Committee approval for each trial site. All Ethics committees have to be registered with Drug Controller General of India (DCGI) without which they cannot approve any clinical trial protocol and has come into effect from 25th February 2013.
      Citation: Indian Journal of Dermatology 2017 62(4):373-379
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_271_17
      Issue No: Vol. 62, No. 4 (2017)
       
  • Informed consent process: Foundation of the
           researcher–participant bond

    • Authors: Amrita Sil, Nilay Kanti Das
      Pages: 380 - 386
      Abstract: Amrita Sil, Nilay Kanti Das
      Indian Journal of Dermatology 2017 62(4):380-386
      Consenting to participate in a clinical research study after being properly and correctly informed upholds the basic ethical principle of “autonomy” in human research. The informed consent is a process by which the physician sensitizes the patient about the nature, procedures, risks benefits, treatment schedules, etc of the study in a language that is non-technical and understandable by the study participant. Informed consent document (ICD) has got two parts: the 'Subject Information Sheet' and the 'Informed Consent Form' (ICF); and they have to be approved by the Institutional Ethics Committee (IEC) before administration. Consent should be obtained without any coercion. In case of a situation where a participant is not able to give informed consent (e.g. unconscious, minor or those suffering from severe mental illness or disability) or is illiterate, it has be obtained from a legally acceptable representative (LAR). If the participant or LAR is unable to read/write, then an impartial witness should be present during the entire informed consent process and must append his/her signatures to the consent form. For children < 7 years, verbal consent is essential and for mature minors (age group 7 to 18 years) informed assent should be obtained.
      Citation: Indian Journal of Dermatology 2017 62(4):380-386
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_272_17
      Issue No: Vol. 62, No. 4 (2017)
       
  • Ethics of safety reporting of a clinical trial

    • Authors: Amrita Sil, Nilay Kanti Das
      Pages: 387 - 391
      Abstract: Amrita Sil, Nilay Kanti Das
      Indian Journal of Dermatology 2017 62(4):387-391
      Clinical trial related injury and serious adverse events (SAE) are a major area of concern. In all such scenarios the investigator is responsible for medical care of the trial participant and also ethically bound to report the event to all the stakeholders of the clinical trial. The trial sponsor is responsible for ongoing safety evaluation of the investigational product, reporting and compensating the participant in case of any SAE. The Ethics Committee and regulatory body of the country are to uphold the ethical principles of beneficence, justice, non-maleficence in such cases. Any unwanted and noxious effect of a drug when used in recommended doses is an adverse drug reaction (ADR) whereas if causal association is not yet established it is termed adverse event (AE). An AE or ADR that is associated with death, in-patient hospitalization, prolongation of hospitalization, persistent or significant disability or incapacity, a congenital anomaly, or is otherwise life threatening is termed as an SAE. The principal investigator reports the event to the licensing authority (DCGI), sponsor and Chairperson of the Ethics Committee (EC) within 24 hours of occurrence of the SAE. This report is furthered by a detailed report by both the investigator and the EC and given to the DCGI who then gives a final decision on the amount of compensation to be given by the sponsor or the sponsor's representative to the grieving party.
      Citation: Indian Journal of Dermatology 2017 62(4):387-391
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_273_17
      Issue No: Vol. 62, No. 4 (2017)
       
  • Propionibacterium acnes and the Th1/Th17 Axis, implications in acne
           pathogenesis and treatment

    • Authors: Kabir Sardana, Gunjan Verma
      Pages: 392 - 394
      Abstract: Kabir Sardana, Gunjan Verma
      Indian Journal of Dermatology 2017 62(4):392-394
      Acne vulgaris is one of the most commonly seen conditions and the immunological link is a topic of active research. Recently, the Th17 pathway has been found to play a pivotal role in acne. The adaptive immune response toward Propionibacterium acnes leads to activation of Th17 axis. Consequently, the Th17 cytokines (IL-17, IL-1 β, IL-6, and tumor growth factor, in turn, activate the various pathogenic steps in acne. Drugs such as Vitamin D3 and isotretinoin which target the Th17 pathway may offer an additional pathway for their therapeutic response.
      Citation: Indian Journal of Dermatology 2017 62(4):392-394
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_483_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Efficacy and safety of terbinafine 500 mg once daily in patients with
           dermatophytosis

    • Authors: P Ravindra Babu, A J S Pravin, Gaurav Deshmukh, Dhiraj Dhoot, Aniket Samant, Bhavesh Kotak
      Pages: 395 - 399
      Abstract: P Ravindra Babu, A J S Pravin, Gaurav Deshmukh, Dhiraj Dhoot, Aniket Samant, Bhavesh Kotak
      Indian Journal of Dermatology 2017 62(4):395-399
      Introduction: Dermatophytosis are the most common fungal infections globally. Terbinafine is considered to have good potency against dermatophytes, but resistance to terbinafine is on the rise. Objective: The objective of this study was to evaluate the efficacy and safety of terbinafine 500 mg given once daily in treatment of patients with superficial dermatophytosis. Materials and Methods: It was a retrospective questionnaire-based survey. Each doctor was given survey questionnaire booklet containing survey forms. Clinical response was graded according to the improvement in the affected lesion. Mycological cure was defined as negative microscopy under potassium hydroxide examination and a negative culture in Sabouraud's dextrose agar. Patients were divided into three groups depending on the duration of therapy, Group A – terbinafine 500 mg for 2 weeks, Group B – terbinafine 500 mg for 4 weeks, and Group C – terbinafine 500 mg for 6 weeks. Results: Total 50 doctors completed the survey involving 440 patients. In Group A, out of 194 patients, 87% (n = 169) patients showed very good response. In Group B, out of 211 patients, 92% (n = 194) of the patients showed very good response with >75% improvement in their lesion. In Group C, out of 35 patients, 80% (n = 30) patients showed very good response. Adverse drug reactions of mild to moderate intensity related to terbinafine were seen in 57 patients. Conclusion: Our survey indicates that terbinafine in a dose of 500 mg given once daily was efficacious and safe in the treatment of patients with dermatophytosis.
      Citation: Indian Journal of Dermatology 2017 62(4):395-399
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_191_17
      Issue No: Vol. 62, No. 4 (2017)
       
  • Histopathological analysis of skin adnexal tumors: A three year study of
           110 cases at a tertiary care center

    • Authors: Kanwalpreet Kaur, Karuna Gupta, Deepika Hemrajani, Ajay Yadav, Kalpana Mangal
      Pages: 400 - 406
      Abstract: Kanwalpreet Kaur, Karuna Gupta, Deepika Hemrajani, Ajay Yadav, Kalpana Mangal
      Indian Journal of Dermatology 2017 62(4):400-406
      Background: Skin adnexal tumors (SAT) encompass wide spectrum of benign and malignant tumors that differentiate toward one or more adnexal structures found in normal skin. Overall incidence of SATs is low yet they can be challenging to diagnose. Aims: The aim of this study is to study the spectrum and microscopic features of SATs. Materials and Methods: It was a retrospective cross-sectional, descriptive study conducted over a period of 3 years. Formalin fixed, paraffin-embedded sections were stained with hematoxylin and eosin for histopathological analysis. Results: Out of the total 34,400 biopsies, 110 cases were diagnosed as SATs comprising 39.09% of tumors with follicular differentiation followed by tumors showing sweat gland differentiation (37.27%), and sebaceous differentiation (23.63%). The age ranged from 5 years to 85 years and male:female ratio was 1.03:1. Most of the tumors were benign (82.73%) while only 17.27% were malignant. Pilomatricoma (28.2%) was the most common benign tumor while sebaceous carcinoma (11.8%) was the most common malignant tumor. Conclusion: Architectural features are of great importance in differentiating benign tumors from malignant.
      Citation: Indian Journal of Dermatology 2017 62(4):400-406
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_380_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Vitamin D level in alopecia areata

    • Authors: Yasmeen Jabeen Bhat, Insha Latif, Rauf Malik, Iffat Hassan, Gousia Sheikh, Kouser Sideeq Lone, Sabiya Majeed, Peerzada Sajad
      Pages: 407 - 410
      Abstract: Yasmeen Jabeen Bhat, Insha Latif, Rauf Malik, Iffat Hassan, Gousia Sheikh, Kouser Sideeq Lone, Sabiya Majeed, Peerzada Sajad
      Indian Journal of Dermatology 2017 62(4):407-410
      Background: Alopecia areata (AA) is an immune-mediated disease in which autoantigens play an important part in activating T-lymphocytes. Vitamin D has been associated with various autoimmune diseases, and Vitamin D receptors are strongly expressed in hair follicles and their expression in keratinocytes is necessary for the maintenance of the normal hair cycle. Aim: The aim of this study was to find the association between Vitamin D level and AA. Materials and Methods: This was a hospital-based cross-sectional study in which 50 patients with clinically and trichoscopically diagnosed AA cases, and 35 healthy age- and sex-matched controls were studied in summer months. Blood samples were taken from both cases as well as controls and samples were immediately processed by centrifugation (4000 rpm) at room temperature. Plasma 25-hydroxyvitamin D (25(OH)D) was analyzed by chemiluminescence method. A deficiency in Vitamin D was defined as serum 25(OH)D concentrations <30 ng/ml. Results: The mean body mass index in cases was 20.96 ± 1.91, whereas in controls, it was 21.37 ± 1.70 (P = 0.31). The mean serum 25(OH)D levels of AA patients was 16.6 ± 5.9 ng/ml, whereas in control group, the mean level was 40.5 ± 5.7, the difference being statistically significant (P < 0.001). A significant negative correlation was found between severity of alopecia tool score and Vitamin D level (P < 0.001; r = −0.730) and also between the number of patches and Vitamin D level (P < 0.001, r = −0.670). Conclusion: In our study, we found that the levels of 25(OH)D were low in AA patients when compared to healthy controls. Furthermore, there was a significant negative correlation between the levels of serum Vitamin D and severity of AA. Thus, the study suggests the role of Vitamin D in pathogenesis of AA and hence a possible role of Vitamin D supplementation in treatment of same. Limitations: Our study was limited by the lesser number of patients and lack of therapeutic trial of Vitamin D for these patients.
      Citation: Indian Journal of Dermatology 2017 62(4):407-410
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_677_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Mucocutaneous manifestations in patients with rheumatoid arthritis: A
           cross-sectional study from Eastern India

    • Authors: Sudip Kumar Ghosh, Debabrata Bandyopadhyay, Surajit Kumar Biswas, Ivoreen Darung
      Pages: 411 - 417
      Abstract: Sudip Kumar Ghosh, Debabrata Bandyopadhyay, Surajit Kumar Biswas, Ivoreen Darung
      Indian Journal of Dermatology 2017 62(4):411-417
      Background: Cutaneous manifestations are fairly common in rheumatoid arthritis (RA) and they can help in early diagnosis, prompt treatment, and hence reduced morbidity from the disease. Aims: The objective of the present study was to find out the different patterns of dermatoses in a group of patients with RA from Eastern India. Methodology: Consecutive patients fulfilling the American Rheumatism Association 1987 revised criteria for the classification of RA and who had different dermatoses were included in this cross-sectional study done over a period of 8 years in a tertiary care hospital in Eastern India. Thorough clinical examination and appropriate laboratory investigations were performed as needed. Data were recorded in a predesigned schedule, and appropriate statistical analysis was done. Results: We studied 111 evaluable patients with an age range of 19–71 years and a female to male ratio of 7:1. The mean disease duration of RA was 6.5 years. Cutaneous infections as a group was the most common mucocutaneous manifestation (34.2%) followed by xerosis including ichthyotic skin changes (27%), pigmented purpuric dermatoses (14.4%), leg ulcer (9.9%), periungual telangiectasia (9.9%), rheumatoid nodules (RNs) (8.1%), purpura and ecchymoses (7.2%), small vessel vasculitis in (7.2%), corn and callosities (6.3%), palmar erythema (4.5%), and neutrophilic dermatosis (4.5%). Raynaud's phenomenon was found in 3.6% patients and panniculitis in (3.6%) patients. Rheumatoid factor (RF) and anti-cyclic citrullinated peptides antibody were positive in 74.8% and 88.3% patients, respectively. No statistically significant difference of incidence of leg ulcer, small vessel vasculitis, RN, or Raynaud's phenomenon could be noted between RF positive and negative groups. Limitations: Being an institution-based study, the study findings may not reflect the true situation in the community which remained a limitation of this study. Conclusion: While some of the features of this study were analogous to Western data, other features showed discordance which may be due to ethnic variations among the patients with RA.
      Citation: Indian Journal of Dermatology 2017 62(4):411-417
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_260_17
      Issue No: Vol. 62, No. 4 (2017)
       
  • Itolizumab in psoriasis

    • Authors: Ankita Srivastava
      Pages: 418 - 421
      Abstract: Ankita Srivastava
      Indian Journal of Dermatology 2017 62(4):418-421
      A number of biologics is being used for the treatment of psoriasis. Itolizumab is one such agent which has been approved in India. It is an anti-CD6 monoclonal antibody that acts by binding to scavenger receptor cysteine-rich (SRCR) distal domain 1 of CD6. Itolizumab has been found to be safe, with infusion reactions as the most common adverse effect. However, its advantages and disadvantages over other biologicals and immunosuppressants need to be established. Also, its utility in treating other immune-mediated disorders is being explored.
      Citation: Indian Journal of Dermatology 2017 62(4):418-421
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_467_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Keratin 17 mutations in four families from India with pachyonychia
           congenita

    • Authors: Manoj Agarwala, Pankaj Salphale, Dincy Peter, Neil J Wilson, Susanne Pulimood, Mary E Schwartz, Frances J D Smith
      Pages: 422 - 426
      Abstract: Manoj Agarwala, Pankaj Salphale, Dincy Peter, Neil J Wilson, Susanne Pulimood, Mary E Schwartz, Frances J D Smith
      Indian Journal of Dermatology 2017 62(4):422-426
      Pachyonychia congenita (PC) is a rare autosomal dominant genetic skin disorder due to a mutation in any one of the five keratin genes, KRT6A, KRT6B, KRT6C, KRT16, or KRT17. The main features are palmoplantar keratoderma, plantar pain, and nail dystrophy. Cysts of various types, follicular hyperkeratosis, oral leukokeratosis, hyperhidrosis, and natal teeth may also be present. Four unrelated Indian families presented with a clinical diagnosis of PC. This was confirmed by genetic testing; mutations in KRT17 were identified in all affected individuals.
      Citation: Indian Journal of Dermatology 2017 62(4):422-426
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_321_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Methodological issues with sampling strategy

    • Authors: Partha Haldar
      Pages: 427 - 427
      Abstract: Partha Haldar
      Indian Journal of Dermatology 2017 62(4):427-427

      Citation: Indian Journal of Dermatology 2017 62(4):427-427
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_241_17
      Issue No: Vol. 62, No. 4 (2017)
       
  • Author&#39;s reply

    • Authors: Suzan Demir Pektas
      Pages: 427 - 428
      Abstract: Suzan Demir Pektas
      Indian Journal of Dermatology 2017 62(4):427-428

      Citation: Indian Journal of Dermatology 2017 62(4):427-428
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_305_17
      Issue No: Vol. 62, No. 4 (2017)
       
  • Myeloma-associated systemic amyloidosis with an extensive cutaneous
           involvement

    • Authors: Parul Aggarwal, Kamal Aggarwal, Sarabjit Kaur, Vijay Kumar Jain
      Pages: 428 - 429
      Abstract: Parul Aggarwal, Kamal Aggarwal, Sarabjit Kaur, Vijay Kumar Jain
      Indian Journal of Dermatology 2017 62(4):428-429

      Citation: Indian Journal of Dermatology 2017 62(4):428-429
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_358_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Nevus lipomatosus cutaneous superficialis with unusual presentation over
           the nipple

    • Authors: Shilpa Bairwa, Mahak Sharma, Ashok Sangwaiya, Sapna Singla, Karuna Gupta, Ajay Yadav
      Pages: 429 - 431
      Abstract: Shilpa Bairwa, Mahak Sharma, Ashok Sangwaiya, Sapna Singla, Karuna Gupta, Ajay Yadav
      Indian Journal of Dermatology 2017 62(4):429-431

      Citation: Indian Journal of Dermatology 2017 62(4):429-431
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_384_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Leishmanial abscess

    • Authors: Sandeep Arora, Satish Mendonca, Ajay Malik, V Ramesh, Renu Khandpal
      Pages: 431 - 433
      Abstract: Sandeep Arora, Satish Mendonca, Ajay Malik, V Ramesh, Renu Khandpal
      Indian Journal of Dermatology 2017 62(4):431-433

      Citation: Indian Journal of Dermatology 2017 62(4):431-433
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_533_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Confusing concepts in study design

    • Authors: Anupam Das, Aparajita Ghosh
      Pages: 433 - 434
      Abstract: Anupam Das, Aparajita Ghosh
      Indian Journal of Dermatology 2017 62(4):433-434

      Citation: Indian Journal of Dermatology 2017 62(4):433-434
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_251_17
      Issue No: Vol. 62, No. 4 (2017)
       
  • Pyodermatitis-pyostomatitis vegetans

    • Authors: Surajit Nayak, Sibasish Patro
      Pages: 434 - 436
      Abstract: Surajit Nayak, Sibasish Patro
      Indian Journal of Dermatology 2017 62(4):434-436

      Citation: Indian Journal of Dermatology 2017 62(4):434-436
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_59_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Multiple noduloulcerative lesions over extremities: Can cytology be
           diagnostic?

    • Authors: Krishnendu Mondal, Rupali Mandal
      Pages: 437 - 439
      Abstract: Krishnendu Mondal, Rupali Mandal
      Indian Journal of Dermatology 2017 62(4):437-439

      Citation: Indian Journal of Dermatology 2017 62(4):437-439
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_460_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Superimposed segmental manifestation of juvenile amyopathic
           dermatomyositis in a 9-year-old boy

    • Authors: Isil Bulur, Hilal Kaya Erdogan, Zeynep Nurhan Saracoglu, Rudolf Happle, Funda Canaz
      Pages: 440 - 440
      Abstract: Isil Bulur, Hilal Kaya Erdogan, Zeynep Nurhan Saracoglu, Rudolf Happle, Funda Canaz
      Indian Journal of Dermatology 2017 62(4):440-440
      Dermatomyositis is a well-known autoimmune disorder. On the other hand, juvenile amyopathic dermatomyositis (JADM) occurs rather rarely. Here, we report an unusual case in a 9-year-old Turkish boy showing a unilateral linear inflammatory skin lesion that was followed, after 16 months, by the appearance of bilateral disseminated features JADM.
      Citation: Indian Journal of Dermatology 2017 62(4):440-440
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_335_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Dermatoscopy in diagnosis of cutaneous myiasis arising in pemphigus
           vulgaris lesions

    • Authors: Keshavamurthy Vinay, Sanjeev Handa, Sumeeta Khurana, Sonu Agrawal, Dipankar De
      Pages: 440 - 440
      Abstract: Keshavamurthy Vinay, Sanjeev Handa, Sumeeta Khurana, Sonu Agrawal, Dipankar De
      Indian Journal of Dermatology 2017 62(4):440-440
      Myiasis, infestation of live human and vertebrate animals by larvae, can complicate ulcers and open wounds. Although myiasis occurs in neglected erosions of pemphigus, such a complication is not documented in the literature. Herein, we report a case of myiasis complicating pemphigus vulgaris and describe its dermatoscopic features.
      Citation: Indian Journal of Dermatology 2017 62(4):440-440
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_354_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Autoimmune bullous disease in childhood

    • Authors: Andac Salman, Burak Tekin, Deniz Yucelten
      Pages: 440 - 440
      Abstract: Andac Salman, Burak Tekin, Deniz Yucelten
      Indian Journal of Dermatology 2017 62(4):440-440
      Background: Autoimmune bullous disorders (AIBDs) are a heterogeneous group of diseases which are rarely seen in children. Studies concerning the immunobullous diseases in pediatric patients are scarce. Aims and Objectives: In this study, we aimed to investigate the clinical features and treatment outcomes of AIBDs in children. Materials and Methods: The electronic records of the patients in our AIBDs outpatient clinic were retrospectively reviewed. All cases diagnosed before the age of 16 years were included in the analysis of clinical features, treatment outcomes, and follow-up data. Results: Of the 196 patients with immunobullous diseases, 9 (4.6%) were diagnosed before the age of 16 years. Mean age of the patients at the time of diagnosis was 7.72 ± 5.66 years. Among nine patients, linear immunoglobulin A disease (LAD), pemphigus vulgaris (PV), and bullous pemphigoid (BP) were seen in 5, 2, and 2 children, respectively. All patients were treated with at least two systemic agents (including methylprednisolone, dapsone, methotrexate, salazopyrine, intravenous Ig [IVIg], and rituximab) leading to clinical remission in all of them after a mean period of 31.77 ± 27.99 months. Conclusion: In line with earlier studies, LAD was the most common immunobullous disease and in general, associated with a favorable response to dapsone. This study was noteworthy in that the patients with PV and BP demonstrated a relatively more recalcitrant course, requiring rituximab and IVIg for remission, respectively. Overall, patients had a good prognosis.
      Citation: Indian Journal of Dermatology 2017 62(4):440-440
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_366_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Severely crusted cheilitis as an initial presentation of systemic lupus
           erythematosus

    • Authors: Wai Man Mandy Chan, Shiu Ming Pang, See Ket Ng
      Pages: 440 - 440
      Abstract: Wai Man Mandy Chan, Shiu Ming Pang, See Ket Ng
      Indian Journal of Dermatology 2017 62(4):440-440
      Lupus erythematosus (LE) is an autoimmune disease which may initially present solely with lip lesions. Due to a wide spectrum of presentation, these features may initially be misdiagnosed as other oral diseases such as lichen planus, erythema multiforme (EM), and actinic cheilitis, leading to a delay in diagnosis and treatment. We discuss a case of severely crusted cheilitis which was initially diagnosed as EM, with subsequent development of subacute cutaneous LE, and progression to systemic LE. We will discuss the clinical and histological features of lupus cheilitis.
      Citation: Indian Journal of Dermatology 2017 62(4):440-440
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_559_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Cortisol homeostasis in the epidermis is influenced by topical
           corticosteroids in patients with atopic dermatitis

    • Authors: Mototsugu Fukaya
      Pages: 440 - 440
      Abstract: Mototsugu Fukaya
      Indian Journal of Dermatology 2017 62(4):440-440
      Background: The skin produces cortisol by itself and regulates its own proliferation and differentiation. There is a possibility that topical corticosteroids (TCSs) influence the cortisol homeostasis in the skin. Aims and Objectives: The author described the density and distribution of cortisol and its parties in the epidermis after application of topical steroids immunohistologically. Materials and Methods: The forearm skin was biopsied before and after 2 weeks' application of clobetasol propionate 0.05% two times a day in one healthy volunteer. The biopsied skin was stained immunohistologically by ant-MLN64, StAR, CPY11A1, cortisol, HSD11B1, HSD11B2, glucocorticoid receptor alpha, glucocorticoid receptor beta (GRB), and mineralocorticoid receptor (MCR) antibodies. The skin biopsy was performed similarly in 19 adult patients with atopic dermatitis who had used TCS for a considerable period. They were 4 TCS present users (TCS+), 12 TCS nonusers with skin manifestation on the biopsied site (TCS-E+) and 3 TCS nonusers without skin manifestation on the biopsied site (TCS-E−). Results: The staining density increased during TCS application in MLN64, cortisol and HSD11B2 in a healthy volunteer. The staining density was stronger in HSD11B2 of the basal layer and MCR of the spinous layer in the TCS-E+ patients than in the TCS+ and TCS-E− patients. The staining density was weaker in MLN64 of the basal and granular layers, HSD11B1 of the basal layer and GRB of the whole layer in the TCS-E+ patients than in the TCS+ and TCS-E− patients. Conclusion: The hypertrophy of the epidermis and insufficient keratinization recognized in the TCS-E+ patients might be caused by the decreased cortisol synthesis regulated by MLN64 and the increased cortisol inactivation by HSD11B2. Decreased GRB and increased MCR might enhance the reactivity of cortisol in the keratinocytes.
      Citation: Indian Journal of Dermatology 2017 62(4):440-440
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_702_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Disappearance of all nevi as initial sign of metastatic melanoma

    • Authors: Antonio Martinez-Lopez, Gonzalo Blasco-Morente, Israel Perez-Lopez, Salvador Arias-Santiago
      Pages: 441 - 441
      Abstract: Antonio Martinez-Lopez, Gonzalo Blasco-Morente, Israel Perez-Lopez, Salvador Arias-Santiago
      Indian Journal of Dermatology 2017 62(4):441-441

      Citation: Indian Journal of Dermatology 2017 62(4):441-441
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_260_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Culture-bounded skin lesion - A case due to Chinese Gua Sha

    • Authors: Viroj Wiwanitkit
      Pages: 441 - 441
      Abstract: Viroj Wiwanitkit
      Indian Journal of Dermatology 2017 62(4):441-441

      Citation: Indian Journal of Dermatology 2017 62(4):441-441
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_352_16
      Issue No: Vol. 62, No. 4 (2017)
       
  • Refractory psoriasis vulgaris with itching successfully treated with the
           anti-interleukin-17A antibody secukinumab: A case of secondary failure of
           other biologic agents

    • Authors: Yuko Kurosaki, Kenji Takamori, Yasushi Suga
      Pages: 441 - 441
      Abstract: Yuko Kurosaki, Kenji Takamori, Yasushi Suga
      Indian Journal of Dermatology 2017 62(4):441-441

      Citation: Indian Journal of Dermatology 2017 62(4):441-441
      PubDate: Mon,10 Jul 2017
      DOI: 10.4103/ijd.IJD_97_17
      Issue No: Vol. 62, No. 4 (2017)
       
 
 
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