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Publisher: Medknow Publishers   (Total: 355 journals)

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Showing 1 - 200 of 355 Journals sorted alphabetically
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advances in Human Biology     Open Access   (Followers: 1)
African J. for Infertility and Assisted Conception     Open Access  
African J. of Business Ethics     Open Access   (Followers: 6)
African J. of Medical and Health Sciences     Open Access   (Followers: 1)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.269, h-index: 10)
African J. of Trauma     Open Access  
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 6)
Anesthesia : Essays and Researches     Open Access   (Followers: 7)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.331, h-index: 15)
Annals of Bioanthropology     Open Access   (Followers: 3)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 13, SJR: 0.408, h-index: 15)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.308, h-index: 14)
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 7, SJR: 0.441, h-index: 10)
Annals of Saudi Medicine     Open Access   (SJR: 0.24, h-index: 29)
Annals of Thoracic Medicine     Open Access   (Followers: 4, SJR: 0.388, h-index: 19)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 15, SJR: 0.148, h-index: 5)
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Intl. Surgery     Open Access   (Followers: 9)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Pharmacy Practice     Open Access   (Followers: 5)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 3)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.879, h-index: 49)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 2, SJR: 0.362, h-index: 10)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Cancer Translational Medicine     Open Access   (Followers: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 1)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access   (Followers: 1)
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 12, SJR: 0.82, h-index: 12)
Contemporary Clinical Dentistry     Open Access   (Followers: 4)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.339, h-index: 19)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.131, h-index: 4)
Dental Research J.     Open Access   (Followers: 9)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 5, SJR: 0.205, h-index: 22)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access  
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.121, h-index: 3)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access   (Followers: 1)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Orthopaedic J.     Open Access  
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.473, h-index: 8)
Environmental Disease     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.496, h-index: 11)
European J. of General Dentistry     Open Access   (Followers: 1)
European J. of Prosthodontics     Open Access   (Followers: 2)
European J. of Psychology and Educational Studies     Open Access   (Followers: 7)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.107, h-index: 5)
Genome Integrity     Open Access   (Followers: 4, SJR: 1.227, h-index: 12)
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
IJS Short Reports     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 8, SJR: 0.302, h-index: 13)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (SJR: 0.318, h-index: 26)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.618, h-index: 16)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.307, h-index: 16)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.243, h-index: 24)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.448, h-index: 16)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 3, SJR: 0.563, h-index: 29)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.292, h-index: 9)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.53, h-index: 34)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.716, h-index: 60)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.207, h-index: 31)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 1, SJR: 0.233, h-index: 12)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.213, h-index: 5)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 4, SJR: 0.203, h-index: 13)
Indian J. of Ophthalmology     Open Access   (Followers: 5, SJR: 0.536, h-index: 34)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 9, SJR: 0.393, h-index: 15)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.218, h-index: 5)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.35, h-index: 12)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 1, SJR: 0.285, h-index: 22)
Indian J. of Pharmacology     Open Access   (SJR: 0.347, h-index: 44)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.303, h-index: 13)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.496, h-index: 15)
Indian J. of Psychological Medicine     Open Access   (Followers: 1, SJR: 0.344, h-index: 9)
Indian J. of Public Health     Open Access   (Followers: 1, SJR: 0.444, h-index: 17)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4, SJR: 0.253, h-index: 14)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.169, h-index: 7)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.313, h-index: 9)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.366, h-index: 16)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 3)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 4, SJR: 0.229, h-index: 13)
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 7)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.239, h-index: 4)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.523, h-index: 15)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 7, SJR: 0.611, h-index: 9)
Intl. J. of Trichology     Open Access   (SJR: 0.37, h-index: 10)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 2)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 4, SJR: 0.427, h-index: 15)
J. of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 8, SJR: 0.416, h-index: 14)
J. of Applied Hematology     Open Access  
J. of Association of Chest Physicians     Open Access   (Followers: 2)
J. of Basic and Clinical Reproductive Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Therapeutics     Open Access   (Followers: 4, SJR: 0.359, h-index: 21)
J. of Carcinogenesis     Open Access   (Followers: 1, SJR: 1.152, h-index: 26)
J. of Cardiothoracic Trauma     Open Access  
J. of Cardiovascular Disease Research     Open Access   (Followers: 3, SJR: 0.351, h-index: 13)
J. of Cardiovascular Echography     Open Access   (SJR: 0.134, h-index: 2)
J. of Cleft Lip Palate and Craniofacial Anomalies     Open Access   (Followers: 2)
J. of Clinical and Preventive Cardiology     Open Access   (Followers: 1)
J. of Clinical Imaging Science     Open Access   (Followers: 1, SJR: 0.277, h-index: 8)
J. of Clinical Neonatology     Open Access   (Followers: 1)
J. of Clinical Ophthalmology and Research     Open Access   (Followers: 2)
J. of Clinical Sciences     Open Access  
J. of Conservative Dentistry     Open Access   (Followers: 4, SJR: 0.532, h-index: 10)
J. of Craniovertebral Junction and Spine     Open Access   (Followers: 4, SJR: 0.199, h-index: 9)
J. of Current Medical Research and Practice     Open Access  
J. of Current Research in Scientific Medicine     Open Access  
J. of Cutaneous and Aesthetic Surgery     Open Access   (Followers: 1)
J. of Cytology     Open Access   (Followers: 1, SJR: 0.274, h-index: 9)
J. of Dental and Allied Sciences     Open Access   (Followers: 1)
J. of Dental Implants     Open Access   (Followers: 7)
J. of Dental Lasers     Open Access   (Followers: 2)
J. of Dental Research and Review     Open Access   (Followers: 1)
J. of Digestive Endoscopy     Open Access   (Followers: 3)
J. of Dr. NTR University of Health Sciences     Open Access  
J. of Earth, Environment and Health Sciences     Open Access   (Followers: 1)
J. of Education and Ethics in Dentistry     Open Access   (Followers: 5)
J. of Education and Health Promotion     Open Access   (Followers: 5)
J. of Emergencies, Trauma and Shock     Open Access   (Followers: 9, SJR: 0.353, h-index: 14)
J. of Engineering and Technology     Open Access   (Followers: 6)
J. of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
J. of Family and Community Medicine     Open Access   (Followers: 2)
J. of Family Medicine and Primary Care     Open Access   (Followers: 10)

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Journal Cover Asian Journal of Transfusion Science
  [SJR: 0.362]   [H-I: 10]   [2 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 0973-6247 - ISSN (Online) 1998-3565
   Published by Medknow Publishers Homepage  [355 journals]
  • A handy chart for the interpretation of sequential differential
           adsorption–elution procedure

    • Authors: Shamee Shastry, Soumya Das
      Pages: 77 - 78
      Abstract: Shamee Shastry, Soumya Das
      Asian Journal of Transfusion Science 2017 11(2):77-78

      Citation: Asian Journal of Transfusion Science 2017 11(2):77-78
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/0973-6247.214338
      Issue No: Vol. 11, No. 2 (2017)
       
  • Hemolysis during component preparation: An inadvertent cause

    • Authors: Puneet Sachdeva, Anubhav Gupta, Hari Krishan Dhawan, Ratti Ram Sharma, Neelam Marwaha
      Pages: 79 - 80
      Abstract: Puneet Sachdeva, Anubhav Gupta, Hari Krishan Dhawan, Ratti Ram Sharma, Neelam Marwaha
      Asian Journal of Transfusion Science 2017 11(2):79-80

      Citation: Asian Journal of Transfusion Science 2017 11(2):79-80
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_89_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • Extracorporeal photopheresis: Review of technical aspects

    • Authors: Satyam Arora, Rasika Setia
      Pages: 81 - 86
      Abstract: Satyam Arora, Rasika Setia
      Asian Journal of Transfusion Science 2017 11(2):81-86
      Extracorporeal photochemotherapy (ECP) is considered as an immune modulating therapy majorly targeting the T cells of the Immune system. ECP induces an anti-inflammatory condition with tolerogenic responses without inducing a global immunosuppression state which is a typical feature of other therapeutic options such as steroids. Clinical indication of ECP has grown over time since its initial applications. Our review discusses the technical aspects of the concept of photopheresis with the available methods for its clinical applications.
      Citation: Asian Journal of Transfusion Science 2017 11(2):81-86
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_87_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • Effectiveness of team-based learning methodology in teaching transfusion
           

    • Authors: Neena Piyush Doshi
      Pages: 87 - 94
      Abstract: Neena Piyush Doshi
      Asian Journal of Transfusion Science 2017 11(2):87-94
      Background: Team-based learning (TBL) combines small and large group learning by incorporating multiple small groups in a large group setting. It is a teacher-directed method that encourages student–student interaction. This study compares student learning and teaching satisfaction between conventional lecture and TBL in the subject of pathology.Aims: The present study is aimed to assess the effectiveness of TBL method of teaching over the conventional lecture.SETTINGS AND DESIGN: The present study was conducted in the Department of Pathology, GMERS Medical College and General Hospital, Gotri, Vadodara, Gujarat. The study population comprised 126 students of second-year MBBS, in their third semester of the academic year 2015–2016.Methodology: “Hemodynamic disorders” were taught by conventional method and “transfusion medicine” by TBL method. Effectiveness of both the methods was assessed. A posttest multiple choice question was conducted at the end of “hemodynamic disorders.” Assessment of TBL was based on individual score, team score, and each member's contribution to the success of the team. The individual score and overall score were compared with the posttest score on “hemodynamic disorders.” A feedback was taken from the students regarding their experience with TBL.Statistical Analysis Used: Tukey's multiple comparisons test and ANOVA summary were used to find the significance of scores between didactic and TBL methods. Student feedback was taken using “Student Satisfaction Scale” based on Likert scoring method.Results and Conclusions: The mean of student scores by didactic, Individual Readiness Assurance Test (score “A”), and overall (score “D”) was 49.8% (standard deviation [SD]-14.8), 65.6% (SD-10.9), and 65.6% (SD-13.8), respectively. The study showed positive educational outcome in terms of knowledge acquisition, participation and engagement, and team performance with TBL.
      Citation: Asian Journal of Transfusion Science 2017 11(2):87-94
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_123_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • Factors influencing transfusion requirement in patients undergoing
           first-time, elective coronary artery bypass graft surgery

    • Authors: Ailin Mazuita Mazlan, Yasmin Ayob, Abd Rahim Hussein, Thiru Kumar Namasiwayam, Wan Mohd. Zahiruddin Wan Mohammad
      Pages: 95 - 101
      Abstract: Ailin Mazuita Mazlan, Yasmin Ayob, Abd Rahim Hussein, Thiru Kumar Namasiwayam, Wan Mohd. Zahiruddin Wan Mohammad
      Asian Journal of Transfusion Science 2017 11(2):95-101
      Context: Coronary artery bypass graft (CABG) operation is associated with high frequency of allogeneic blood transfusion due to the acquired hemostatic challenges in patients undergoing CABG. However, allogeneic blood transfusion carries risks of infection, adverse reaction, and mortality as well as prolonged hospital stay and increased hospital cost. It is important to identify patients who require blood transfusion to mitigate their risk factors and reduce the chance of exposure to allogeneic blood.Aims: This study was conducted to evaluate factors that influence the decision to transfuse red cell in first-time elective CABG patients.Settings and Design: This was a cross-sectional study based on a retrospective record review. The study was done in the National Heart Institute.Materials and Methods: All patients who underwent first-time elective CABG were included in this study. Variables analyzed include age, gender, body weight, preoperative hemoglobin (Hb) level, patients' comorbidities, and other clinical parameters.Statistical Analysis Used: Data were analyzed using SPSS software version 20.Results: A total of 463 patients underwent first-time elective CABG during the period of the study. Three hundred and eighty-six (83.4%) patients received red cell transfusion. From multiple logistic regression analysis, only age (odds ratio [OR] = 1.040, 95% confidence interval [CI]: 1.003, 1.077, P = 0.032), body weight (OR = 0.951, 95% CI: 0.928, 0.974, P < 0.001), Hb level (OR = 0.500, 95% CI: 0.387, 0.644, P < 0.001), and cardiopulmonary bypass time (OR = 1.013, 95% CI: 1.004, 1.023, P < 0.001) were the significant independent predictors of red cell transfusion.Conclusions: By stratifying patients according to their risk factor for red cell transfusion, the high-risk patients could be recognized and should be enrolled into effective patient blood management program to minimize their risk of exposure to allogeneic blood transfusion.
      Citation: Asian Journal of Transfusion Science 2017 11(2):95-101
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_51_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • Role of low plasma volume treatment on clinical efficacy of plasmapheresis
           in neuromyelitis optica

    • Authors: Akshay Batra, Sundar Periyavan
      Pages: 102 - 107
      Abstract: Akshay Batra, Sundar Periyavan
      Asian Journal of Transfusion Science 2017 11(2):102-107
      Background: Neuromyelitis optica (NMO) is an autoimmune demyelinating disease preferentially targeting the optic nerves and spinal cord. Plasmapheresis (PP) is an effective adjunct therapy in severe NMO attacks. The recommended minimum plasma volume to be treated per session of PP is equivalent to total plasma volume (TPV) of the patient.Aim: To study the effect of lower plasma volume treated in patients with NMO on clinical efficacy of plasmapheresis in comparison to minimum recommended volume.Methods: This retrospective study was done on acute NMO patients who were managed with PP at our center. Patients who had 5 sessions of PP, spread over 10 days, were included. Clinical outcome was defined as per predefined criteria.Results: 24 patients who underwent PP for acute NMO met our inclusion criteria. Females (age; mean (SD) 33.7 (11.2) years) were more common (n = 18). The minimum recommended plasma volume (PV) that was supposed to be treated per patient during entire acute therapeutic period was 195.5 (14.6) mL per kilogram-body-weight (kg-bw). We treated lower plasma volume (mean (SD) 112.7 (17.0) mL per kg-bw); the difference was significant (P < 0.05). The volume treated was same across the gender (P > 0.05). Significant clinical improvement was observed in 79% of patients (n = 19) after 6 months. There were no significant differences in volume of plasma treated, between patients who had moderate and marked improvement; also, who did, and did not have significant clinical improvement (P > 0.05; for both).Conclusions: Plasmapheresis is a safe and efficient add-on therapy in NMO, especially in steroid-resistant cases. Although the volumes of plasma treated during acute plasmapheresis were less than recommended minimum volumes, majority of patients had significant clinical improvement.
      Citation: Asian Journal of Transfusion Science 2017 11(2):102-107
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_111_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • Compliance score as a monitoring tool to promote treatment adherence in
           children with thalassemia major for improved physical growth

    • Authors: Sarala Kannan, Amarjeet Singh
      Pages: 108 - 114
      Abstract: Sarala Kannan, Amarjeet Singh
      Asian Journal of Transfusion Science 2017 11(2):108-114
      Background/Hypothesis: Creeping monotony in the treatment provides minimal motivation for children with beta-thalassemia major, leading to noncompliance for adequate blood transfusions and iron chelation therapy. This study was envisaged to formulate a clinical compliance score and correlate the score with their linear growth velocity and weight gain.Materials and Methods: A prospective longitudinal study among 30 thalassemia children aged between 1 and 18 years was conducted in the Department of Pediatrics, Tata Main Hospital (TMH), Jamshedpur, from July 2012 to January 2014. Relevant clinical information and investigations were recorded using a predesigned pro forma. Compliance score was calculated using pre-, post-transfusion hemoglobin and serum ferritin levels. The height velocity and weight gain were calculated. The same patients were re-assessed in January 2015.Results and Discussion: Mean age of children was 10.18 ± 4.98 years. Forty percent were females. Using the scoring table, 33% were in good category of compliance while 4% had poor compliance. The mean height velocity was significantly higher in good compliance category as compared to average or poor score category in 2014 (P = 0.017). Good compliance score children continued to maintain higher height velocity during the 1-year follow-up (P = 0.02). Average weight gain was higher in good compliance category.Conclusion: This paper brings out a simple, regularly monitored scoring system to promote growth in thalassemia children through improved compliance to treatment, which incentivized them to maintain or improve their scores for better height velocity and weight gain. No such compliance score has been tabulated for thalassemia patients as of date.
      Citation: Asian Journal of Transfusion Science 2017 11(2):108-114
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_61_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • Red cell alloimmunization in repeatedly transfused patients

    • Authors: Dimel K Bhuva, Jitendra H Vachhani
      Pages: 115 - 120
      Abstract: Dimel K Bhuva, Jitendra H Vachhani
      Asian Journal of Transfusion Science 2017 11(2):115-120
      Introduction: Repeated blood transfusions can result in the production of alloantibodies against one or more red cell antigens, which complicates subsequent transfusions. Aims: The study was done to find incidence of various red cell alloantibodies; to determine the type of alloantibody; to identify the factors such as frequency of transfusion, splenectomy status, donor ethnicity and gender and their association with the development of antibody in repeatedly transfused patients. Materials and Methods: This study was carried out in Dept. of IHBT, Shree M. P. Shah Medical College, Jamnagar, Gujarat. Blood was taken from the patients of thalassemia major, sickle cell disease, chronic renal failure, post partum haemorrhage, aplastic anemia, Myelodysplastic syndrome with more than 10 red cell transfusions. The plasma/serum was used for antibody screening and antibody identification test. Three cell antibody screening was performed using antihuman globulin gel cards (ID-Card LISS/Coombs) and three cell panel (ID-DiaCell I,II,III-Asia). Those with positive antibody screening were analyzed further for antibody identification test using eleven cell panel (Set ID-Dia Panel). Results: Antibody screening and identification was done in 2 consecutive set of samples (n = 300) which showed, nine (9) patients (3%) were alloimmunized. All repeatedly transfused patients had developed alloantibody before the starting of study period, no patient developed new alloantibody during study period. Conclusions: Alloantibodies should be identified in repeatedly transfused patients and should be given corresponding antigen negative blood unit which will minimize the antibody mediated destruction of transfused red cells.
      Citation: Asian Journal of Transfusion Science 2017 11(2):115-120
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/0973-6247.214347
      Issue No: Vol. 11, No. 2 (2017)
       
  • INRA, a new high-frequency antigen in the INDIAN (IN023) blood group
           system

    • Authors: Sanmukh R Joshi, Ankita Sheladiya, Kinjal V Mendapara-Dobariya
      Pages: 121 - 123
      Abstract: Sanmukh R Joshi, Ankita Sheladiya, Kinjal V Mendapara-Dobariya
      Asian Journal of Transfusion Science 2017 11(2):121-123
      Background: The INDIAN blood group system comprises 4 antigens sensitive to enzymes and 2-aminoethyl isothiouronium bromide (AET).AIM: The patient's antibody was investigated for its specificity to the high-frequency antigens (HFA) of this system.Material and Methods: Low ionic strength solution (LISS)-tube/LISS-indirect antiglobulin test (IAT) methods were used. The patient's red blood cells (RBCs) were tested with antisera to HFA. Her antibody was tested with RBCs lacking the HFA. Furthermore, it was tested with RBCs as untreated or treated with enzyme or AET. The genetic sequence was studied for mutation in CD44 gene that encodes INDIAN antigens.Results: The patient was grouped A1B, RhD+, antibody screening test positive, direct antiglobulin test negative. A negative autocontrol test had suggested to the alloantibody being present. Antibody had agglutinated RBCs in LISS-tube at RT and by LISS-IAT at 37°C. The RBCs of the 11-cell panel, those lacking HFA and from 50 random donors, were agglutinated by her antibody indicating its specificity to the HFA, though the RBCs of Lu (a-b-)/In (Lu) type showed a weaker reaction. The patient's RBCs were agglutinated by antisera to a number of the enzyme-sensitive HFA, including those of INDIAN blood groups. The antibody showed reduced reactivity with the RBCs treated with papain, chymotrypsin, and AET but resistant to trypsin and dithiothreitol. The patient's genetic sequence revealed a novel homozygous mutation 449G>A in exon 5 of CD44.Conclusion: The antibody to enzyme sensitive HFA was tested for serological and molecular genetics studies and found to be directed to the novel HFA, named as INRA of the INDIAN blood group system and was assigned a numerical symbol IN: 005 by the International Society of Blood Transfusion (ISBT).
      Citation: Asian Journal of Transfusion Science 2017 11(2):121-123
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/0973-6247.214337
      Issue No: Vol. 11, No. 2 (2017)
       
  • Dedicated donor unit transfusions reduces donor exposure in pediatric
           surgery patients

    • Authors: Satyam Arora, Neelam Marwaha, Hari Krishan Dhawan, K. L. N. Rao
      Pages: 124 - 130
      Abstract: Satyam Arora, Neelam Marwaha, Hari Krishan Dhawan, K. L. N. Rao
      Asian Journal of Transfusion Science 2017 11(2):124-130
      Background: Many strategies have been explored to reduce multiple donor exposures in neonates such as use of restrictive transfusion protocols, limiting iatrogenic blood loss, use of recombinant erythropoietin and single donor programs. Method: In our study we assessed the feasibility of dedicating single donor units with reserving all the components from the same donor for the specified neonates/ infants undergoing surgery and estimating reduction of donor exposure. Fifty neonates undergoing surgery were included in the prospective study group and the transfusion details were compared with 50 retrospective cases with same inclusion criteria. Results: An intra-operative blood loss of >13 ml/Kg was significantly associated with transfusion (P<0.05) which was most frequently administered in the intra-operative period. Donor exposure rate of overall transfusion was 1.15 in the study group as compared to 4.03 in the retrospective control group. In study group Donor Exposure Rate (DER): Transfusion Rate (TR) ratio was 1:1.5 and Transfusion per Donor Unit (TPDU) of 1.5, means that one donor unit contributed to 1.5 transfusions in each patient and contributed to 50% reduction in donor exposure in each patient as compared to retrospective control group. Conclusion: Our study showed that by practicing dedicated donor unit transfusion policy, for neonates undergoing surgery we could significantly reduce the donor exposure.
      Citation: Asian Journal of Transfusion Science 2017 11(2):124-130
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_57_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • Comparison of antibody titers using conventional tube technique versus
           column agglutination technique in ABO blood group incompatible renal
           transplant

    • Authors: Amit Bhangale, Amardeep Pathak, Smita Pawar, Tarun Jeloka
      Pages: 131 - 134
      Abstract: Amit Bhangale, Amardeep Pathak, Smita Pawar, Tarun Jeloka
      Asian Journal of Transfusion Science 2017 11(2):131-134
      Introduction: Measurement of alloantibody titer to a red cell antigen (ABO titers) is an integral part of management of ABO incompatible kidney transplants (ABOiKT). Material and Methods: There are different methods of titer estimation. Alloantibody detection by tube titration and Gel agglutination columns are accepted methodologies. It is essential to find the difference in titers between the two methods so as to set the 'cut-off' titer accordingly, depending upon the method used. Results: We did a prospective observational study to compare and correlate the ABO titers using these two different techniques – conventional tube technique (CTT) and the newer column agglutination technique (CAT). A total of 67 samples were processed in parallel for anti-A/B antibodies by both tube dilution and column agglutination methods. The mean titer by conventional tube method was 38.5 + 96.6 and by the column agglutination test was 96.4 + 225. The samples correlated well with Spearman rho correlation coefficient of 0.94 (P = 0.01). Conclusion: The column agglutination method for anti A/B titer estimation in an ABO incompatible kidney transplant is more sensitive, with the column agglutination results being approximately two and half fold higher (one more dilution) than that of tube method.
      Citation: Asian Journal of Transfusion Science 2017 11(2):131-134
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/0973-6247.214343
      Issue No: Vol. 11, No. 2 (2017)
       
  • Evaluation of process excellence tools in improving donor flow management
           in a tertiary care hospital in South India

    • Authors: Divya Venugopal, Aboobacker Mohamed Rafi, Susheela Jacob Innah, Bibin T Puthayath
      Pages: 135 - 139
      Abstract: Divya Venugopal, Aboobacker Mohamed Rafi, Susheela Jacob Innah, Bibin T Puthayath
      Asian Journal of Transfusion Science 2017 11(2):135-139
      Background: Process Excellence is a value based approach and focuses on standardizing work processes by eliminating the non-value added processes, identify process improving methodologies and maximize capacity and expertise of the staff.Aim and Objectives: To Evaluate the utility of Process Excellence Tools in improving Donor Flow Management in a Tertiary care Hospital by studying the current state of donor movement within the blood bank and providing recommendations for eliminating the wait times and to improve the process and workflow.Materials and Methods: The work was done in two phases; The First Phase comprised of on-site observations with the help of an expert trained in Process Excellence Methodology who observed and documented various aspects of donor flow, donor turn around time, total staff details and operator process flow. The Second Phase comprised of constitution of a Team to analyse the data collected. The analyzed data along with the recommendations were presented before an expert hospital committee and the management.Results: Our analysis put forward our strengths and identified potential problems. Donor wait time was reduced by 50% after lean due to better donor management with reorganization of the infrastructure of the donor area. Receptionist tracking showed that 62% of the total time the staff wastes in walking and 22% in other non-value added activities. Defining Duties for each staff reduced the time spent by them in non-value added activities. Implementation of the token system, generation of unique identification code for donors and bar code labeling of the tubes and bags are among the other recommendations.Conclusion: Process Excellence is not a programme; it's a culture that transforms an organization and improves its Quality and Efficiency through new attitudes, elimination of wastes and reduction in costs.
      Citation: Asian Journal of Transfusion Science 2017 11(2):135-139
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/0973-6247.214354
      Issue No: Vol. 11, No. 2 (2017)
       
  • Comparison of two algorithms to confirm and discriminate samples initially
           reactive for nucleic acid amplification tests

    • Authors: Aseem Kumar Tiwari, Ravi C Dara, Dinesh Arora, Geet Aggarwal, Ganesh Rawat, Vimarsh Raina
      Pages: 140 - 146
      Abstract: Aseem Kumar Tiwari, Ravi C Dara, Dinesh Arora, Geet Aggarwal, Ganesh Rawat, Vimarsh Raina
      Asian Journal of Transfusion Science 2017 11(2):140-146
      Background: Blood centers in India have published individual donor nucleic acid testing (ID-NAT) data based on an algorithm (Algorithm A) where serologically negative, NAT reactive sample was subsequently tested with discriminatory NAT (d-NAT), and on the basis of d-NAT, initial reactive samples were classified as “NAT yield” or inconclusive. We followed Algorithm B based on replicate testing and Ultrio Plus assay and compared the results with Algorithm A with Ultrio assay.Materials and Methods: Results of ID-NAT using two algorithms were analyzed.Results: A total of 88,583 (31,844 with Algorithm A and 56,739 with Algorithm B) samples were tested. Among serology nonreactive donations, NAT inconclusive results came down from 95.2% in Algorithm A to 73.1% in Algorithm B (P = 0.0001). Discriminated yield (DY) rate went up from 4.7% in Algorithm A to 21.9% in Algorithm B (P = 0.001).Conclusion: The study data suggest that replicate testing strategy and Ultrio Plus reduce the number of “inconclusive results” seen with earlier commonly used algorithm. We recommend a replicate testing strategy in ID-NAT testing since it will increase the DY and will eliminate the unnecessary discriminatory tests.
      Citation: Asian Journal of Transfusion Science 2017 11(2):140-146
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/0973-6247.214330
      Issue No: Vol. 11, No. 2 (2017)
       
  • Rapid dry plasma thawing system: An alternative to conventional thawing
           baths

    • Authors: S Sanooja Pinki, Ganesh Mohan, Aboobacker Mohamed Rafi, Susheela Jacob Innah, Tom Thomas
      Pages: 147 - 150
      Abstract: S Sanooja Pinki, Ganesh Mohan, Aboobacker Mohamed Rafi, Susheela Jacob Innah, Tom Thomas
      Asian Journal of Transfusion Science 2017 11(2):147-150
      Background: Fresh frozen plasma (FFP) should be thawed before transfusing to the patient. Prolonged or uncontrolled thawing can denature plasma proteins. The potential risk of contamination by wet thawing had always been a point of concern.Aims: Here, we compared and evaluated the effect of thawing on clotting factor activities by two different methods (wet and dry) and other factors such as risk of bacterial contamination, throughput, turnaround time, and efficacy of thawing.Subjects and Methods: All FFPs were prepared from Group O donors and stored at −40°C. Twenty-one FFPs were thawed in Plasmatherm II at 45°C for 15 min and another 21 were thawed in thawing bath at 37°C for 20–30 min randomly. Analysis of prothrombin time, activated partial thromboplastin time, fibrinogen, and factor VIII was done in ACL TOP 300 (IL) at the time of preparation and immediately after thawing of FFPs. Volume, duration of thawing, ease of use, accessibility, and equipment maintenance were also compared.Results: There was a statistically significant difference in coagulation parameters after thawing in both methods compared to the time of preparation (P < 0.05), but all values were within normal limits. There was no significant difference in coagulation parameters between the two methods (P > 0.05). Mixed bacterial growth was observed from swabs taken from the water bath.Conclusion: Plasmatherm II can be a good alternative to water bath to rapidly thaw FFPs by preserving coagulation factors and eliminating the risk of bacterial contamination.
      Citation: Asian Journal of Transfusion Science 2017 11(2):147-150
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/0973-6247.214356
      Issue No: Vol. 11, No. 2 (2017)
       
  • Insight into donor deferral pattern based on peripheral blood counts: An
           experience from South Pakistan

    • Authors: Sadia Sultan, Syed Mohammed Irfan, Mohammad Amjad Baig, Syed Mohammad Usman, Umme Aiman Shirazi
      Pages: 151 - 155
      Abstract: Sadia Sultan, Syed Mohammed Irfan, Mohammad Amjad Baig, Syed Mohammad Usman, Umme Aiman Shirazi
      Asian Journal of Transfusion Science 2017 11(2):151-155
      Background: Donor deferral owing to anemia is one of the major causative factors of temporary donor rejection, which is preventable and treatable. The basic knowledge about frequency, types, and severity of anemia among donors will help plan a strategy to promote donor recruitment and overall national health.Objective: The objective of this study was to provide the predonation deferral rate of the healthy blood donors based on peripheral blood counts and second to determine the types of anemia along with its severity.Materials and Methods: Prospective records of all the reported donors were collected from January 2014 to December 2015 at Liaquat National Hospital, Karachi, Pakistan. Donor samples were analyzed on an automated hematology analyzer.Results: Overall, 36,954 potential donors reported to the blood bank, out of which 33,853 were selected and 3101 were deferred, which makes the deferral rate of 8.39%. Majority of donors (n = 2663 [7.20%]) were deferred based on peripheral blood counts. Based on peripheral count, anemia (91.8%) represents the major cause of deferral, followed by raised total leukocyte count (3.7%) and polycythemia (3.3%), and thrombocytopenia (1.0%) was the least potential cause. Microcytic-hypochromic anemia was found in 58.5% of the donors followed by normocytic and macrocytic anemia in 38.9% and 2.4%, respectively. Mild anemia was seen in 78.2% followed by moderate and severe anemia in 20.5% and 1.18%, respectively.Conclusion: A high prevalence of anemia among blood donors signifies deteriorating health status not only in donor population but also in general population. This situation calls for more concerted efforts as otherwise it would lead to decreased blood donor pool.
      Citation: Asian Journal of Transfusion Science 2017 11(2):151-155
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/0973-6247.214357
      Issue No: Vol. 11, No. 2 (2017)
       
  • Therapeutic leukocyte reduction for acute and chronic myeloid leukemias: A
           4-year experience from an oncology center in India

    • Authors: Anita A Tendulkar, Puneet A Jain, Abhaykumar Gupta, Nidhi Sharma, Anisha Navkudkar, Vijaya Patle
      Pages: 156 - 161
      Abstract: Anita A Tendulkar, Puneet A Jain, Abhaykumar Gupta, Nidhi Sharma, Anisha Navkudkar, Vijaya Patle
      Asian Journal of Transfusion Science 2017 11(2):156-161
      Introduction: Hyperleukocytosis (HL) and leukostasis seen in myeloid leukemias are a medical emergency. We present a case series of ten such patients in a 4-year period. Sixteen therapeutic leukocyte reduction (TLR) were done in ten cases along with other supportive measures. The American Society for Apheresis supports the routine implementation of TLR in cases of HL secondary to myeloid leukemias with signs of leukostasis.Materials and Methods: The procedures were performed on the intermittent flow cell separator after discussion with the treating physician about patient's condition. Clinical, demographic, analytical, and technical variables were reviewed retrospectively and the patients were followed up at the end of 4 years. Descriptive analysis was performed for all variables, and relationships between quantitative variables and categorical variables were determined by applying the Student's t-test.Results: The mean age of presentation was 34 years. Priapism was the most common symptom followed by respiratory distress and neurological disturbances. After an average of 1.6 TLR procedures, the mean leukocyte count reduction achieved was 39.9% along with symptomatic relief. The mean survival at 4-year follow-up was 12.8 months and the overall mortality was 20%. Acute myeloid leukemia patients presented with lower mean platelet counts compared to chronic myeloid leukemia patients; however, the platelet loss in the final product was minimized.Conclusion: TLR is a safe and effective therapy for leukoreduction in hematological malignancies in our experience.
      Citation: Asian Journal of Transfusion Science 2017 11(2):156-161
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_103_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • Knowledge and attitude of donating and using cord blood for transfusion
           among patients attending Nnamdi Azikiwe University Teaching Hospital,
           Nnewi, South East Nigeria

    • Authors: Chide E Okocha, Nkiru N Ezeama, John C Aneke, Chinyere U Onubogu, Charles I Okafor, Chijioke G Egbunike
      Pages: 162 - 170
      Abstract: Chide E Okocha, Nkiru N Ezeama, John C Aneke, Chinyere U Onubogu, Charles I Okafor, Chijioke G Egbunike
      Asian Journal of Transfusion Science 2017 11(2):162-170
      Background: Allogeneic blood for transfusion is in short supply in most parts of the developing world. Cord blood for transfusion can be a significant source of blood supply to our health institutions.Aims: This study aims to investigate the knowledge and attitude to the donation and use of umbilical cord blood (UCB) for transfusion among the patients receiving services in a tertiary health institution in South-East Nigeria.Materials and Methods: This was a cross-sectional study; an anonymous structured questionnaire was used. A total of 549 consenting patients randomly selected from the antenatal, postnatal, sickle cell clinics, and wards were the subjects. Statistical analysis of the data was done using SPSS version 20.0. Results: The mean age of the participants was 31.9 ± 9.5 years. The majority were females (77.2%), married (86.4%). About 26.2% of the respondents were willing to accept UCB for transfusion to them or their child. Following counseling, the acceptance rate increased to 71.5%. Most of the respondents (80.0%) were willing to donate the UCB of their baby; or be tested for HIV (93.3%), if necessary. Educational level was significantly associated with knowledge of UCB. After logistic regression, occupation, and gender were significantly associated with acceptance of UCB for transfusion. Up to 52% belonged to low income family background, approximately 150 US dollars monthly family income (50,000 naira).Conclusion: The knowledge and acceptance of UCB for transfusion are low in our environment. However, proper counseling and public enlightenment could change this attitude.
      Citation: Asian Journal of Transfusion Science 2017 11(2):162-170
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_113_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • Detection of T and B cells specific complement-fixing alloantibodies using
           flow cytometry: A diagnostic approach for a resource limited laboratory

    • Authors: Dharmendra Jain, Pranav Dorwal, Amit Pande, Neetu Tyagi, Simmi Mehra, Vimarsh Raina
      Pages: 171 - 179
      Abstract: Dharmendra Jain, Pranav Dorwal, Amit Pande, Neetu Tyagi, Simmi Mehra, Vimarsh Raina
      Asian Journal of Transfusion Science 2017 11(2):171-179
      Background and Objectives: Various methods have been reported for the detection of antibodies in recipient sera, which can be human leukocyte antigens (HLAs) or non-HLA specific, complement- or noncomplement fixing, as well as donor T (HLA-Class-I) and/or B cell (HLA-Class-I and II) specific. These alloantibodies play a pivotal role in antibody-mediated renal transplantation rejection. Deposition of C4d in peritubular capillaries of a kidney biopsy is a marker of antibody-mediated rejection. The C4d flow-panel reactive antibodies (PRAs) are a screening method for HLA-specific and complement fixing antibodies. However, the method is limited by the lack of donor specificity.Design and Settings: Here, we present a new and simple flow cytometric method referred to as C4d-flow cytometry crossmatch (C4d-FCXM) for the detection of donor-specific (T and/or B cell) and C4d-fixing alloantibodies.Results: The method was applied in a series of clinical cases and judged to be useful. The method may limit unwanted deferral of the donor due to positivity in C4d Flow-PRA and/or FCXM and may be helpful in prediction of antibody mediated rejections. Furthermore, this method can provide information pretransplant in contrast to kidney biopsy and C4d evaluation done posttransplant.Conclusions: We postulate that this method incorporates most of the features of all the available modalities (i.e., National Institute of Health-complement dependent lymphocytotoxicity, FCXM, cytotoxic FCXM and C4d-flowPRA) yet cost-effective and best suited for resource-limited laboratory/ies which is a common scenario in developing countries.
      Citation: Asian Journal of Transfusion Science 2017 11(2):171-179
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/0973-6247.214355
      Issue No: Vol. 11, No. 2 (2017)
       
  • Transfusion-related adverse reactions in pediatric and surgical patients
           at a tertiary care teaching hospital in India

    • Authors: Kunal J Ghataliya, Jigar D Kapadia, Mira K Desai, KM Mehariya, GH Rathod, Nidhi Bhatnagar, MD Gajjar
      Pages: 180 - 187
      Abstract: Kunal J Ghataliya, Jigar D Kapadia, Mira K Desai, KM Mehariya, GH Rathod, Nidhi Bhatnagar, MD Gajjar
      Asian Journal of Transfusion Science 2017 11(2):180-187
      Background: Use of blood and its components is lifesaving. However, their use is often associated with adverse events.Objective: To analyze the pattern of adverse reactions associated with transfusion of blood and its components in pediatric and surgical patients at a tertiary care teaching hospital.Materials and Methods: Patients receiving transfusion of blood or its components in a randomly selected unit each from Departments of Pediatrics, including thalassemia OPD and surgery, were monitored intensively for a period of 6 months. Clinical course, management, outcome, causality, severity, seriousness, and preventability of observed transfusion reactions (TRs) were analyzed.Results: A total of 411 pediatric and 433 surgical patients received 594 and 745 transfusions respectively during the study period. Of these, TRs were observed in 69 (11.6%) children and 63 (8.4%) surgical patients. Majority of reactions in children (48, 69.5%) and surgical patients (51, 80.9%) were acute, developing within 24 h of transfusion. TRs were observed with packed cells (13.2%), cryoprecipitate (10%), platelet concentrate (14.3%) and fresh frozen plasma (1.3%) in pediatric patients and with packed cells (7.2%), whole blood (25%) and platelet concentrate (62.5%) in surgical patients. Most common TRs included febrile nonhemolytic TRs (FNHTRs) and allergic reactions. Reactions were more frequent in patients with a previous history of transfusion or those receiving more than one transfusion and in children, when transfusion was initiated after 30 min of issue of blood component. Majority of reactions were managed with symptomatic treatment, were nonserious, moderately severe, probably preventable and probably associated with the suspect blood component in both populations. Conclusion: Transfusion reactions in children and surgical patients are commonly observed with cellular blood components. Majority of reactions are acute and nonserious. FNHTRs and allergic reactions are the most common transfusion reactions. Risk of transfusion reactions is more in patients receiving multiple transfusions.
      Citation: Asian Journal of Transfusion Science 2017 11(2):180-187
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/0973-6247.214348
      Issue No: Vol. 11, No. 2 (2017)
       
  • The prozone effect exerted by the complement-binding anti-Lea on anti-D

    • Authors: Sanmukh R Joshi, Kamlesh H Parekh
      Pages: 188 - 191
      Abstract: Sanmukh R Joshi, Kamlesh H Parekh
      Asian Journal of Transfusion Science 2017 11(2):188-191
      Background: Prozone phenomenon is seen with very high-titer antibodies in an immune serum.Aim: The prozone effect on anti-D by a low-titer anti-Lea was investigated associated with neonatal jaundice. Materials and Methods: Standard methods were used in investigations.Results: The child was born at full-term developed mild jaundice. With weak direct antiglobulin test+, her indirect serum bilirubin was progressed to 27.5 mg/dL in 48 h. Anti-D and anti-Lea were detected in the mother. Both these antibodies were detected in the child's serum though the eluate from red blood cells (RBCs) contained only anti-D. Mother's anti-D was masked by anti-Lea if the RBCs possessed both the antigens together. Anti-D was revealed only with D-positive RBCs lacking Lea or if the serum was modified by mixing with Lea+ saliva or was heated at 56°C or fortified with citrate solution.Conclusion: An anti-D showed prozone effect exerted by the complement-fixing anti-Lea in the test.
      Citation: Asian Journal of Transfusion Science 2017 11(2):188-191
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/0973-6247.214328
      Issue No: Vol. 11, No. 2 (2017)
       
  • Successful surgical procedure in a patient of aplastic anemia with
           platelet refractoriness, using cross-match compatible platelets

    • Authors: Ritam Chakrabarty, Sudipta Sekhar Das
      Pages: 192 - 194
      Abstract: Ritam Chakrabarty, Sudipta Sekhar Das
      Asian Journal of Transfusion Science 2017 11(2):192-194
      This case marks the beginning of issuing cross-matched platelet products in Eastern India. A known case of aplastic anemia, on regular transfusion support, now presented with obstructed ventral periumbilical hernia requiring urgent surgical intervention. Platelet count at presentation was 13,000/μL. Platelet cross-matching was done by solid phase method. Ten units of random donor platelets were crossmatched. Five units were compatible and transfused. Counts rose to 84,000/μL after 1 h. Surgery was completed successfully. Thus, 50% units were compatible. This indicates possible underlying alloimmunization. Rapid count rise enabled completion of this urgent surgery. This rapid rise of platelet count would not have been possible without cross matching. We conclude that platelet cross matching is a powerful tool for alloimmunized patients.
      Citation: Asian Journal of Transfusion Science 2017 11(2):192-194
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_115_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • Autoimmune hemolytic anemia caused by anti “e”: A challenge: A
           case report with review of literature

    • Authors: Sangeeta Pahuja, Deepti Verma
      Pages: 195 - 198
      Abstract: Sangeeta Pahuja, Deepti Verma
      Asian Journal of Transfusion Science 2017 11(2):195-198
      Autoimmune hemolytic anemia (AIHA) is featured by short red cell survival due to autoantibodies. AIHA caused by anti 'e' is a tough clinical situation as antigen 'e' is a highly prevalent antigen. The present case highlights the same and different issues related to it.
      Citation: Asian Journal of Transfusion Science 2017 11(2):195-198
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_76_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • Coinheritance of hemoglobin D-Punjab and &#946;0-thalassemia 3.4 kb
           deletion in a Thai girl

    • Authors: Sitthichai Panyasai, Sarinna Rahad, Sakorn Pornprasert
      Pages: 199 - 202
      Abstract: Sitthichai Panyasai, Sarinna Rahad, Sakorn Pornprasert
      Asian Journal of Transfusion Science 2017 11(2):199-202
      Hemoglobin (Hb) D-Punjab [β 121(GH4) Glu→ln; HBB: C.364G>C] and β0-thalassemia 3.4 kb deletion are very rare in the Thai population. For the first time, the coinheritance of HbD-Punjab with β0-thalassemia 3.4 kb deletion was reported in a 7-year-old Thai girl. She had mild anemia (Hb 115.0 g/L and mean corpuscular hemoglobin 18.1 pg) with red blood cell microcytosis (mean corpuscular volume 52.5 fL). By capillary electrophoresis (CE), HbD-Punjab was found at a migration position of 180 s with the value of 81.9% while the level of HbA2was 7.3%. Based on the elevated HbA2, the molecular analysis for detection of β0-thalassemia mutations was performed. The 490 bp amplified fragments from β0-thalassemia 3.4 kb deletion was observed. Thus, the coinheritance of HbD-Punjab with β0-thalassemia can be found in the Thai population. The HbA2measured on CE is a reliable parameter for differentiating the homozygote of HbD-Punjab and compound heterozygote of HbD-Punjab and β0-thalassemia.
      Citation: Asian Journal of Transfusion Science 2017 11(2):199-202
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_117_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • Acute respiratory distress syndrome in a neonate due to possible
           transfusion-related acute lung injury

    • Authors: Arti Maria, Sheetal Agarwal, Anu Sharma
      Pages: 203 - 205
      Abstract: Arti Maria, Sheetal Agarwal, Anu Sharma
      Asian Journal of Transfusion Science 2017 11(2):203-205
      Transfusion-related acute lung injury (TRALI) is a potentially life-threatening complication of blood component transfusion. It is relatively underdiagnosed entity in neonates with scant literature. We report a case of TRALI in a preterm neonate developing acute respiratory distress within 6 h of blood product transfusion in the absence of preexisting lung disease. Prompt ventilator and supportive management were instituted. The baby showed clinical and radiological improvement within 12 h; however, he succumbed to death due to acute massive pulmonary hemorrhage 36 h later. Possibility of TRALI should be kept if there is sudden deterioration of lung function after blood transfusion.
      Citation: Asian Journal of Transfusion Science 2017 11(2):203-205
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_120_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • Daily plasma exchange in severe Guillain–Barré syndrome helps
           in early weaning from ventilator: A lesson from a case

    • Authors: Arunpreet Kaur, Archana Bajpayee, Nitin Kumar Bajpai, Nikhil Kothari
      Pages: 206 - 208
      Abstract: Arunpreet Kaur, Archana Bajpayee, Nitin Kumar Bajpai, Nikhil Kothari
      Asian Journal of Transfusion Science 2017 11(2):206-208
      Intravenous immunoglobulin (IVIG) and therapeutic plasma exchange (TPE) are well-known therapeutic modalities in Guillain–Barré syndrome (GBS). In developing countries like India, where plasma-derived products (IVIG) are not easily available, and affordable TPE is preferred. Here, we reported a case of severe GBS, who was treated with daily plasma exchange (PLEX) rather than recommended alternate day schedule. A 16-year-old male adolescent of severe GBS, i.e., on mechanical ventilator was treated with the plasmapheresis regimen consisted of removal of 1.3 plasma volumes in each cycle for total of five cycles, on daily basis. The patient's condition started improving after three cycles of TPE with power in the upper limbs 4/5 and lower limbs 3/5 and completely weaned off from ventilator after the 4th TPE, i.e. the 4th day of admission. This case emphasizes the need of daily PLEX regimen particularly in severe GBS patients because early weaning from ventilator reduces the ventilator-associated complications, hospital stay as wells as less morbidity, and mortality in severe GBS.
      Citation: Asian Journal of Transfusion Science 2017 11(2):206-208
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/0973-6247.214346
      Issue No: Vol. 11, No. 2 (2017)
       
  • Interference of daratumumab with pretransfusion testing, mimicking a
           high-titer, low avidity like antibody

    • Authors: Mei-Hwa Lin, Fei-Yun Liu, Hsiu-Mien Wang, Hsin-Ching Cho, Shyh-Chyi Lo
      Pages: 209 - 211
      Abstract: Mei-Hwa Lin, Fei-Yun Liu, Hsiu-Mien Wang, Hsin-Ching Cho, Shyh-Chyi Lo
      Asian Journal of Transfusion Science 2017 11(2):209-211
      Daratumumab is a monoclonal immunoglobulin against CD38 and has been approved for treating patients with refractory multiple myeloma. The presence of daratumumab in the sera can interfere with pretransfusion testing due to the weakly expression of CD38 on red cells. The reactivity could be mistaken as autoantibody (if autocontrol is positive) or alloantibody (if autocontrol is negative). We present a case that demonstrates daratumumab could mimic a high titer low avidity (HTLA) alloantibody. A 34-year-old male patient of refractory myeloma was recruited in phase three clinical trial involving daratumumab. Samples were sent to the blood bank for pretransfusion testing. Without knowledge of patient having used daratumumab, we mistook the reactivity in the patient's sera as an HTLA antibody due to the results of negative autocontrol and high titers of antibody activity. Antibody screen showed a panreactive pattern and the reactivity against screening cells was up to a titer of 1: 1240. The reactivity was weaker against cord cells than adult cells, became weaker against ZZAP-treated cells and became negative against DDT-treated cells. A discussion with attending physician finally revealed the reactivity was due to the interference caused by daratumumab. The case demonstrates good communication is essential in performing pretransfusion testing for patients receiving daratumumab and other new biological regimens that can interfere with compatibility test.
      Citation: Asian Journal of Transfusion Science 2017 11(2):209-211
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/0973-6247.214358
      Issue No: Vol. 11, No. 2 (2017)
       
  • Out of the blue: Blue blood.!

    • Authors: Lenin Babu Elakkumanan, Jayasree Cherukat, Jane Nithya Tolson, Sarath Sistla, Abhishekh Basavarajegowda
      Pages: 212 - 212
      Abstract: Lenin Babu Elakkumanan, Jayasree Cherukat, Jane Nithya Tolson, Sarath Sistla, Abhishekh Basavarajegowda
      Asian Journal of Transfusion Science 2017 11(2):212-212

      Citation: Asian Journal of Transfusion Science 2017 11(2):212-212
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_75_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • HIV risk associated with nucleic acid testing tested seronegative blood
           donation where the donor was not preassessed for the risk

    • Authors: Kanjaksha Ghosh, Kanchan Misra
      Pages: 213 - 214
      Abstract: Kanjaksha Ghosh, Kanchan Misra
      Asian Journal of Transfusion Science 2017 11(2):213-214

      Citation: Asian Journal of Transfusion Science 2017 11(2):213-214
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_136_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • Adding up the evidence: Trigger for prophylactic plasma transfusion

    • Authors: Manish Raturi, Shamee Shastry, Poornima B Baliga
      Pages: 214 - 215
      Abstract: Manish Raturi, Shamee Shastry, Poornima B Baliga
      Asian Journal of Transfusion Science 2017 11(2):214-215

      Citation: Asian Journal of Transfusion Science 2017 11(2):214-215
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_63_16
      Issue No: Vol. 11, No. 2 (2017)
       
  • Hello&#8230;. there is a blob of quark in my cryo bag!!

    • Authors: Atul Sonker, Anju Dubey, Rajendra Chaudhary
      Pages: 215 - 216
      Abstract: Atul Sonker, Anju Dubey, Rajendra Chaudhary
      Asian Journal of Transfusion Science 2017 11(2):215-216

      Citation: Asian Journal of Transfusion Science 2017 11(2):215-216
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/0973-6247.214351
      Issue No: Vol. 11, No. 2 (2017)
       
  • Use of “smartphone” technology for managing workload in
           transfusion-transmissible infection (nucleic acid testing) laboratory for
           platelet concentrate inventory management resulting in timely issue of
           platelets: Experience from a tertiary care center

    • Authors: Rekha Hans, Suresh Sharma, Neelam Marwaha, Suchet Sachdev, Hari Krishan Dhawan, Ashish Jain, Ratti Ram Sharma
      Pages: 217 - 218
      Abstract: Rekha Hans, Suresh Sharma, Neelam Marwaha, Suchet Sachdev, Hari Krishan Dhawan, Ashish Jain, Ratti Ram Sharma
      Asian Journal of Transfusion Science 2017 11(2):217-218

      Citation: Asian Journal of Transfusion Science 2017 11(2):217-218
      PubDate: Mon,11 Sep 2017
      DOI: 10.4103/ajts.AJTS_149_16
      Issue No: Vol. 11, No. 2 (2017)
       
 
 
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