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Anwer Khan Modern Medical College J.     Open Access   (Followers: 2)
Bangabandhu Sheikh Mujib Medical University J.     Open Access  
Bangladesh Critical Care J.     Open Access  
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Bangladesh J. of Anatomy     Open Access  
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Bangladesh J. of Bioethics     Open Access   (Followers: 2)
Bangladesh J. of Botany     Open Access   (SJR: 0.242, h-index: 8)
Bangladesh J. of Child Health     Open Access  
Bangladesh J. of Dental Research & Education     Open Access   (Followers: 1)
Bangladesh J. of Endosurgery     Open Access   (Followers: 2)
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Bangladesh J. of Medical Biochemistry     Open Access   (Followers: 2)
Bangladesh J. of Medical Education     Open Access   (Followers: 1)
Bangladesh J. of Medical Physics     Open Access  
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Bangladesh J. of Medicine     Open Access   (Followers: 1)
Bangladesh J. of Nutrition     Open Access   (Followers: 2)
Bangladesh J. of Orthodontics and Dentofacial Orthopedics     Open Access  
Bangladesh J. of Otorhinolaryngology     Open Access  
Bangladesh J. of Pharmacology     Open Access  
Bangladesh J. of Plant Breeding and Genetics     Open Access   (Followers: 2)
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Bangladesh J. of Plastic Surgery     Open Access  
Bangladesh J. of Scientific and Industrial Research     Open Access  
Bangladesh J. of Scientific Research     Open Access  
Bangladesh J. of Urology     Open Access   (Followers: 2)
Bangladesh J. of Veterinary Medicine     Open Access  
Bangladesh Medical J. Khulna     Open Access  
Bangladesh Medical Research Council Bulletin     Open Access   (SJR: 0.148, h-index: 12)
Bangladesh Pharmaceutical J.     Full-text available via subscription   (Followers: 1)
BIRDEM Medical J.     Open Access   (Followers: 2)
Cardiovascular J.     Open Access   (Followers: 2)
Chittagong University J. of Biological Sciences     Open Access  
City Dental College J.     Open Access   (Followers: 2)
Community Based Medical J.     Open Access  
Delta Medical College J.     Open Access  
Dhaka University J. of Biological Sciences     Open Access  
Dhaka University J. of Pharmaceutical Sciences     Open Access   (Followers: 2, SJR: 0.184, h-index: 6)
Dhaka University J. of Science     Open Access  
Eastern Librarian     Open Access   (Followers: 10)
Faridpur Medical College J.     Open Access   (Followers: 1)
GANIT : J. of Bangladesh Mathematical Society     Open Access  
Ibrahim Cardiac Medical J.     Open Access  
Ibrahim Medical College J.     Open Access  
Intl. Current Pharmaceutical J.     Open Access   (Followers: 2)
Intl. J. of Agricultural Research, Innovation and Technology     Open Access   (Followers: 1)
Intl. J. of Natural Sciences     Open Access   (Followers: 1)
Intl. J. of Pharmaceutical and Life Sciences     Open Access   (Followers: 3)
J. of Advanced Veterinary and Animal Research     Open Access   (Followers: 4)
J. of Armed Forces Medical College, Bangladesh     Open Access  
J. of Bangladesh Society of Physiologist     Open Access  
J. of Bio-Science     Open Access  
J. of Business and Technology (Dhaka)     Open Access  
J. of Chemical Engineering     Open Access   (Followers: 3)
J. of Dhaka Medical College     Open Access  
J. of Dhaka National Medical College & Hospital     Open Access  
J. of Enam Medical College     Open Access  
J. of Environmental Science and Natural Resources     Open Access   (Followers: 2)
J. of Life and Earth Science     Open Access  
J. of Medicine     Open Access   (Followers: 1)
J. of Paediatric Surgeons of Bangladesh     Open Access  
J. of Science Foundation     Open Access   (Followers: 1)
J. of Scientific Research     Open Access  
J. of Shaheed Suhrawardy Medical College     Open Access  
J. of Surgical Sciences     Open Access  
J. of the Asiatic Society of Bangladesh, Science     Open Access  
J. of the Bangladesh Association of Young Researchers     Open Access  
J. of the Bangladesh Chemical Society     Open Access  
Jahangirnagar University Environmental Bulletin     Open Access  
KYAMC J.     Open Access  
Medicine Today     Open Access  
Microbes and Health     Open Access   (Followers: 2)
Northern Intl. Medical College J.     Open Access  
Northern University J. of Law     Open Access  
Philosophy and Progress     Open Access  
Progressive Agriculture     Open Access   (Followers: 1)
SAARC J. of Agriculture     Open Access  
South East Asia J. of Public Health     Open Access   (Followers: 2)
Stamford J. of English     Open Access   (Followers: 1)
Stamford J. of Microbiology     Open Access  
The Agriculturists     Open Access  
University Heart J.     Open Access  
University J. of Zoology, Rajshahi University     Open Access  
Update Dental College J.     Open Access  
Bangladesh Pharmaceutical Journal
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     ISSN (Print) 0301-4606
     Published by Bangladesh Journals Online Homepage  [85 journals]
  • New Health Concerns Vol.16(1)
    • Authors: Md Akbar Hossain, Sharif Tanvir
      DOI : Bangladesh Pharmaceutical Journal 16(1): 117-120, 2013
      PubDate: 2013-04-09
      Issue No: Vol. 16 (2013)
  • New Drugs Approval Vol.16(1)
    • Authors: Md Akbar Hossain, Sharif Tanvir
      DOI : Bangladesh Pharmaceutical Journal 16(1): 121-123, 2013
      PubDate: 2013-04-09
      Issue No: Vol. 16 (2013)
  • Design and Development of Sustained Release Microspheres of Ibuprofen by
           Emulsification Solvent Evaporation Method Using Polymeric Blend
    • Authors: Nandini Saha, Ikramul Hasan, Mehrina Nazmi, Md Selim Reza
      Abstract: Ibuprofen, a non-steroidal anti-inflammatory drug was formulated as microspheres by using Methocel K4M & Eudragit RSPO. These microspheres were prepared by emulsification solvent evaporation method to provide sustained action and to minimize local side effect of Ibuprofen by avoiding the drug release in the upper gastrointestinal tract. The prepared microspheres were subjected to various evaluation and in-vitro release studies. In-vitro drug release was studied in a paddle type dissolution apparatus (USP Type II Dissolution Apparatus) using Phosphate buffer (pH 7.4) as the dissolution medium at 37.5oC for 6 hours (paddle speed 50 RPM). The release mechanisms were explored and explained with Zero Order, First Order, Higuchi and Korsmeyer-Peppas equations. The correlation coefficients values of the trend lines of the graphs showed that the formulations best fit with Korsmeyer-Peppas release pattern. Microspheres’ morphology and chemical integrity were studied by a scanning electron microscope (SEM) and Fourier transforms infrared spectroscopy (FTIR) respectively.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 39-44, 2013
      PubDate: 2013-04-08
      Issue No: Vol. 16 (2013)
  • Enhancement of Dissolution Rate of Gliclazide Using Solid Dispersions:
           Characterization and Dissolution Rate Comparison
    • Authors: Sharmi Islam, Laboni Rani Dey, Mohammad Shahriar, Irin Dewan, SM Ashraful Islam
      Abstract: In this study solid dispersion (SDs) of gliclazide were prepared by solvent evaporation technique using poloxamer 407 as carrier. Drug carrier weight ratio were 1:1, 1:3 and 1:5. Physical mixtures of the same ratio were also prepared for comparison. The solid dispersions were investigated for drug loading and dissolution behavior and were found effective to enhance the solubility of gliclazide in dissolution medium significantly. Evaluation of the properties of the SDs was also performed by using Fourier-transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) studies. The FTIR spectroscopic studies showed the stability of gliclazide and absence of interaction between gliclazide and poloxomer 407. The XRD studies indicated the amorphous state of gliclazide in SDs. Dissolution data of SDs were compared by using both model dependant and model independent techniques. No significant difference in % DE (dissolution efficiency) was found among the SDs. But the drug release rate from SDs differs from that of physical mixture. So, solid dispersion technique may be an effective way to enhance dissolution rate of gliclazide.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 45-52, 2013
      PubDate: 2013-04-08
      Issue No: Vol. 16 (2013)
  • Antibiotic Sensitivity of Pathogens Causing Urinary Tract Infection
    • Authors: Taslima Akter, Zakaria Mia, Masum Shahriar
      Abstract: Diagnosis of urinary tract infection (UTI) causing pathogens with their sensitivity to different antibiotics was performed with a total of 96 samples from both male (n=31; 32.3%) and female (n=65; 67.7%) of different age groups. Out of 96 urine samples, 55 (57.3%) were found positive after culturing in MacConkey agar plates. The percent distribution of positive cases against collected samples was higher for female (67%) than male (32%). However, female and male at the reproductive age of 16-30 years were more susceptible to UTI. A total of 55 bacterial isolates were identified by conventional methods and their antibiotic sensitivity was tested using Mueller- Hinton agar plates. The predominant isolates were Escherichia coli (34.5%), Klebsiella sp. (18.2%) and Staphylococci (20.0%). The sensitivity pattern for most of the isolated organisms showed 50% and/or higher sensitivity to imipenem, azithromycin and cephalexin, except Staphylococci (only 9.09% to azithromycin).
      DOI : Bangladesh Pharmaceutical Journal 16(1): 53-58, 2013
      PubDate: 2013-04-08
      Issue No: Vol. 16 (2013)
  • Evaluation of Analgesic and Anti-inflammatory Effects of a Poly-herbal
           Ayurvedic Formulation
    • Authors: Mohammad Jashim Uddin, Md Abdul Motaleb Bhuiyan, Kishor Mazumder, Mohammad Shohel, Md Belayet Hossain, Abu Asad Chowdhury, Md Abdul Mazid
      Abstract: A poly-herbal ayurvedic formulation containing Sida retusa (root), Withania somnifera, Frillaria roylei, and Paederia foetida (prasarini) is used in the treatment of inflammation and pain based on the long-term experience of the ayurvedic physicians, but no scientific study has been carried out so far. We have evaluated the analgesic and anti-inflammatory activities of the poly-herbal preparation using different animal models such as hot plate method for analgesic activity and anti-inflammatory activity by carrageenan-induced inflammation. Significant analgesic activity of the poly-herbal formulation was found after 2 hours as compared to the control. The product also showed sufficient anti-inflammatory activity while checked against carrageenan induced inflammation.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 59-62, 2013
      PubDate: 2013-04-08
      Issue No: Vol. 16 (2013)
  • Bioactivities of Artocarpus chaplasha Roxb. and Bougainvillea spectabillis
    • Authors: Farjana Chowdhury, Senjuti Pal, Tasnuva Sharmin, Ridwan Bin Rashid, Md. Al Amin Sikder, Shaila Kabir, Mohammad S Rahman, Mohammad A Rashid
      Abstract: The methanol extracts of leaf of Artocarpus chaplasha Roxb. and Bougainvillea spectabillis Willd. as well as their petroleum ether, carbon tetrachloride, chloroform and aqueous soluble partitionates were subjected to screenings for antioxidant, cytotoxic, thrombolytic, membrane stabilizing and antimicrobial activities. The antioxidant potential was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and Folin- Ciocalteau reagent using butylated hydroxytolune (BHT) and ascorbic acid as standards. The aqueous soluble fraction of the crude methanol extract of A. chaplasha and the methanolic crude extract of B. spectabillis demonstrated the highest free radical scavenging activity with the IC50 of 15.60±0.27 μg/ml and 18.33±0.17 μg/ml, which could be correlated to their total phenolic content of 61.26±0.23 and 50.00±0.19 mg of GAE/gm of extractive, respectively. Different extractives of A. chaplasha and B. spectabillis showed clot lysis activity ranging from 2.56±0.68% to 17.07±0.23% and 2.24±0.71% to 17.59±0.74% as compared to 66.77% and 3.791 % produced by the standard streptokinase and water, respectively. In hypotonic solution and heat induced conditions, the crude extract of A. chaplasha inhibited the haemolysis of human erythrocyte by 41.96±0.87% and 40.00±0.78%, while the carbon tetrachloride soluble fraction of methanol extract of B. spectabillis inhibited haemolysis by 65.68±0.36% and 35.62±0.82%, respectively. Here, acetyl salicylic acid (0.1 mg/ml) was used as reference showing 72.79% and 42.12% of haemolysis of RBCs in hypotonic and heat induced conditions, respectively. Among the extractives of both plants, the crude methanol extract of A. chaplasha and the chloroform soluble fraction of B. spectabillis extract revealed mild to moderate antimicrobial activity with zone of inhibition ranging from with 7.0 to 13.0 mm. The general toxicity was determined by brine shrimp lethality bioassay where the pet-ether soluble fraction of A. chaplasha (LC50 0.781±0.36 μg/ml) and the aqueous soluble partitionate of B. spectabillis (LC50 1.28±0.57 μg/ml) suggested the presence of considerable bioactive principles.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 63-68, 2013
      PubDate: 2013-04-08
      Issue No: Vol. 16 (2013)
  • A Validated RP-HPLC Method for Simultaneous Estimation of Antidiabetic
           Drugs Pioglitazone HCl and Glimepiride
    • Authors: Khohinur Hossain, Asma Rahman, Md Zakir Sultan, Farhana Islam, Md Akteruzzaman, Md Abdus Salam, Mohammad A Rashid
      Abstract: A simple, fast and economic reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed and validated for simultaneous and quantitative analyses of pioglitazone HCl and glimepiride in pharmaceutical dosage forms. The method was developed using the mobile phase comprising of potassium dihydrogen phosphate buffer (KH2PO4) at pH 3.4 and acetonitrile in the ratio of 40:60 (v/v) over C-18 bonded silica column (250 x 4.6 mm, 5 um, Phenomenex Inc.) at ambient temperature. The flow rate was at 0.8 min/min and the eluent was monitored by UV detection at 235 nm. The recoveries were found to be >97% for pioglitazone and >99% for glimepiride, demonstrative of accuracy of the protocol. Inter-day and intra-day precision of the new method were less than the maximum allowable limit (RSD% ≤ 2.0) according to ICH, USP and FDA guidelines. The method showed linear response with correlation coefficient (r2) values of 0.9991 for pioglitazone and 0.9999 for glimepiride. Therefore, the method was found to be accurate, reproducible, sensitive and less time consuming and can be successfully applied for the assay of pioglitazone and glimepiride in combined formulations.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 69-75, 2013
      PubDate: 2013-04-08
      Issue No: Vol. 16 (2013)
  • Capacity of Non Ionic and Ionic Surfactants for Solubilisation of
    • Authors: Tamanna Rahaman, Jannatul Fardous, Faria Farzana Perveen, Sakina Sultana
      Abstract: The present study was conducted to investigate the solubilising capacity of polyvinylpyrrollidone (PVP K-30), Polyethylene glycol (PEG 6000), Polysorbate (Tween 80) and Sodium lauryl sulphate (SLS) for paracetamol. In our study, PVP K-30 exhibited 5 times, Tween 80 showed 3 times and SLS displayed 2 times higher solubilising capacity than water. Here, PVP K-30 exhibited the highest solubilising capacity and the value was 6.36 ± 0.063 (mg /ml), whilst PEG 6000 in the same study failed to show any significant increase (p> 0.05, unpaired t-test, two-tailed).
      DOI : Bangladesh Pharmaceutical Journal 16(1): 77-80, 2013
      PubDate: 2013-04-08
      Issue No: Vol. 16 (2013)
  • Levels of Heavy Metals in Different Tissues of Pigeon (Columba livia) of
           Bangladesh for Safety Assessment for Human Consumption
    • Authors: Aleya Begum, Sabrina Sehrin
      Abstract: Heavy metal pollution was reported in commercially valuable and edible pigeon (Columba livia, Gmelin 1789) of Bangladesh. The concentrations of As, Pb, Cd, Cr, Zn, and Cu were investigated in the muscle, intestine, kidney, gizzard and liver. For this 60 C. livia were selected from five locations to assess the degree of pollution by heavy metals in pigeon. Significant differences in heavy metal concentrations were observed among different tissues, but not among the locations. The ranges of the measured concentrations (μg/g dry weight) in the tissues of C. livia were as follows: arsenic: (0.01–0.04), (0.02–0.04), (0.02–0.08), (0.02–0.04) and (0.03–0.07); lead: (0.21–0.56), (0.07–1.64), (0.62–1.97), (0.41–0.79) and (1.47–5.75); cadmium: (0.01–-0.05), (0.13–0.97), (0.53–1.85), (0.32– 0.78) and (0.22–2.41); chromium: (0.25–1.93), (1.18–5.90), (1.59–4.40), (1.15–1.65) and (1.38–8.36); zinc: (73.22–256.56), (95.62–130.75), (19.87–67.18), (108.99–124.77) and (159.80–280.76); copper: (3.44–7.64), (5.30–17.50), (8.72–16.55), (1.19–34.42) and (26.09–43.60) in the muscle, intestine, kidney, gizzard, and liver, respectively. This research showed that the liver appeared to be the main storage site of heavy metals, while the muscle had the lowest levels of the analyzed metals. The concentrations of metal in the muscles were not found to exceed the acceptable level for human consumption.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 81-87, 2013
      PubDate: 2013-04-08
      Issue No: Vol. 16 (2013)
  • Membrane Stabilizing and Preliminary Hypoglycemic Activities of Picrasma
    • Authors: Tasnuva Sharmin, Farhana Islam, Md. Al Amin Sikder, Shaila Kabir, Mohammad Rashedul Haque, Mohammad A Rashid
      Abstract: The methanol extract of leaves of Picrasma javanica Blume and its n-hexane, carbon tetrachloride, chloroform and aqueous soluble partitionates were evaluated for membrane stabilizing and preliminary hypoglycemic activities. In hypotonic solution and heat-induced conditions, the crude methanol extract inhibited 65.30±0.52% and 36.79±0.38% haemolysis of RBC as compared to 72.79% and 42.12% produced by standard drug, acetyl salicylic acid, respectively (0.10 mg/ml). The crude extract also showed blood sugar lowering efficacy at 200 and 400 mg/ kg body weight, with 48.63% reduction of blood sugar level at 400 mg/kg body weight while the standard drug, Glibenclamide (10 mg/kg body weight) demonstrated 53.7% reduction of blood sugar level at 3rd hour of administration.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 89-92, 2013
      PubDate: 2013-04-08
      Issue No: Vol. 16 (2013)
  • Removal of Remazol Red from Textile Waste Water Using Treated Sawdust - An
           Effective Way of Effluent Treatment
    • Authors: Nargish Jahan Ara, Md Abu Hasan, Mohammad Arifur Rahman, Md Abdus Salam, Abdus Salam, AM Shafiqul Alam
      Abstract: Activated carbon prepared from sawdust is endeavored as adsorbent for the removal of reactive dye, namely Remazol Red (RR) from aqueous media. The adsorption of RR has been studied onto activated sawdust at various particle size, adsorbent dose, temperature and pH values. The adsorptions of the above mentioned dye were designed for the Langmuir and Freundlich Isotherms. Pseudo first and second order kinetic models were used to calculate the amount adsorbed at equilibrium (q<sub>e</sub>). The calculated values of qe for pseudo-second order equation were found to be in good agreement with those of experimental values. The monolayer capacity (qm) for treated sawdust (8.00 mg g–1) is greater than commercial charcoal (0.074 mg g–1). It is established that treated sawdust has been used as a better adsorbent for the removal of RR as compared to commercial charcoal. This process may eventually be used to get industrial waste free purified water.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 93-98, 2013
      PubDate: 2013-04-08
      Issue No: Vol. 16 (2013)
  • Evaluation of Cardiovascular Activity of an Ayurvedic Product
           ‘Mrityunjay’ in Rat Model
    • Authors: Most Shammi Rahman, Shahana Jahan, Kamrun Nahar, Nazia Islam, Danis Rahman, Ridwan Bin Rashid, Abu Asad Chowdhury, Rebecca Banoo, Mohammad Shah Amran
      Abstract: Ayurvedic system of medicine is a major component of indigenous systems of medicine in Bangladesh. We used an Ayurvedic drug ‘Mrityunjay’ which is traditionally used for high blood pressure, heart diseases and heartquake. We measured the electrocardiographical (ECG) parameters using an ECG machine (Vet 300, EDAN, China) in rat model before and after administration of the test drug. We observed that, Mrityunjay at high doses (800 μg/Kg, 1600μg/kg, 3200μg/kg) produced heart blocks and other arrhythmias, but in normal dose (200μg/Kg) it has no serious untoward effects on cardiac muscle.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 99-105, 2013
      PubDate: 2013-04-08
      Issue No: Vol. 16 (2013)
  • Preparation and Evaluation of Gastroretentive Floating Pellets of
    • Authors: Shahriar Nowshad, Md Saiful Islam Pathan
      Abstract: Traditionally metronidazole is used in the treatment of bacterial vaginosis, trichomoniasis, amoebiasis and is also used in combination with other drugs to treat Helicobacter pylori (H. pylori) that causes stomach or intestinal ulcers. The main aim of this study was to develop a gastroretentive floating pellets for the treatment of above pathological conditions. Such kind of dosage form may provide an extension of drug presence in the upper GI tract resulting enhanced absorption and improved bioavailability for the treatment against protozoa and bacteria. Nine formulations of metronidazole floating pellets such as F1, F2, F3, F4, F5, F6, F7, F8 and F9 were prepared by ionic gelation method using different quantities of sodium alginate and psyllium husk. The drug and polymer ratio were 1:1.4, 1:1.5, 1:1.6, 1:1.6; 1:1.7, 1:1.8, 1:1.8, 1:1.9 and 1:2.0, respectively. The in vitro drug release study was carried out in 900 ml phosphate buffer (pH 7.4) at 37±0.50C and 50 rpm for 12 hours using USP XXIV paddle method and the content of drug release was determined by UV spectrometer at 277nm. Maximum and minimum drug release were found in F1 (88.63%) and in F6 (73.21%), respectively. It indicates that increase in sodium alginate concentration decreases drug release. All the formulations were buoyant for more than 12 hours in simulated gastric fluid at 370C. The maximum and minimum bulk density tapped were 0.57 and 0.52 in F1 and F9, respectively where drug loading were 14.07% in F1 and 12.56% in F9 which indicates that bulk density of the pellets is directly proportional to drug loading. The maximum and minimum swelling were in F3 (75%) and F7 (59%), respectively which demonstrate that swelling of pellets were inversely proportional to the sodium alginate concentration but it is directly proportional to psyllium husk content. In addition, the psyllium husk keeps the GI tract healthy by scavenging toxins and residues of digestive systems. Therefore, it can be concluded that combination of sodium alginate and biodegradable psyllium husk can be prospectively used for the preparation of gastroretentive floating pellets.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 107-115, 2013
      PubDate: 2013-04-08
      Issue No: Vol. 16 (2013)
  • Effects of Ethanolic Extract of Hibiscus rosa-sinensis Leaves on
           Alloxan-Induced Diabetes with Dyslipidemia in Rats
    • Authors: Al Mamun, Saiful Islam, AHM Khurshid Alam, Md Aziz Abdur Rahman, Mamunur Rashid
      Abstract: Diabetes associated dyslipidemia is one of the major causes of disability in western as well as in developing countries. The present study was designed to investigate the effect of ethanolic extract of Hibiscus rosa sinensis (EHBS) leaves on alloxan-induced diabetes with dyslipidemia in rats. Treatment of alloxan-induced diabetes with most effective observed dose (2.0 mg/kg body weight) of EHBS for 1 week significantly reduced glucose level, TC, TG and LDL-C, with the increase of HDL-C and weight of kidney, pancreas and liver when compared with diabetic rats. The observation was also made for consecutive 4 weeks to confirm the results obtained in one week model. Like one week, we got similar results when the treatment of alloxan-induced rats was done with the EHBS for 4 weeks. The results indicated that the EHBS leaves, in comparison with metformin, had profound hypoglycemic and hypolipidemic activities.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 27-31, 2013
      PubDate: 2013-04-07
      Issue No: Vol. 16 (2013)
  • In vitro Effect of Aqueous Extract of Fresh Leaves of Abroma augusta L on
           the Diffusion of Glucose
    • Authors: Md Tariqul Islam, Md Ajijur Rahman, Md Anwar-Ul Islam
      Abstract: There have been a number of reports concerning the role of dietary fiber in hampering the diffusion of glucose and lowering the postprandial serum glucose. The present study investigates the effect of viscous aqueous leaf extract of Abroma augusta L (Family: Sterculiaceae, Bengali name: Ulatkambal, English name: Devil's cotton, DC) on the diffusion of glucose in vitro. Different mixtures were prepared using varying concentrations of sodium carboxymethylcellulose (Na-CMC) and aqueous extract of A. augusta with a fixed concentration of glucose. The diffusion of glucose from these systems into the outer medium through the ultra-fine membrane was measured. The results showed that both Na-CMC and aqueous extract of ulatkambal significantly (p<0.05) reduced the diffusion of glucose compared to control in a concentration-dependent manner. The result of this study suggested that dietary fiber present in the aqueous leaf extract of A. augusta may be potentially effective in the management of type 2 diabetes mellitus by reducing post-prandial glucose absorption from the gastrointestinal tract.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 21-26, 2013
      PubDate: 2013-04-07
      Issue No: Vol. 16 (2013)
  • Antimicrobial and Cytotoxic Activities of Secondary Metabolites Obtained
           from a Novel Species of Streptomyces
    • Authors: Tahmida Sharmin, Md Ajijur Rahman, Abu Sayeed Md Anisuzzaman, Md Anwar-Ul Islam
      Abstract: With an aim to isolate actinomycetes having antimicrobial and cytotoxic activities, five colonies of actinomycetes were collected from soils of a vegetable garden of Rajshahi District, Bangladesh and designated as ANTS-1 to ANTS-5. Initial screening for antibacterial activity showed that the isolate ANTS-1 produced potent antimicrobial metabolites in the culture media. The crude ethyl acetate extract obtained from the yeast-extract glucose agar (YEGA) medium showed strong activity against pathogenic bacteria and moderate activity against fungi. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of the extract against the test bacteria were in the range of 1-2 μg/ml and 4-8 μg/ml, respectively. The LC50 value of the crude extract against brine-shrimp nauplii was only 0.4μg/ml indicating its potent cytotoxic activity. One component of the extract was identified as actinomycin D by interpretation of the spectral data and by comparison with published values.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 15-19, 2013
      PubDate: 2013-04-07
      Issue No: Vol. 16 (2013)
  • Binding Affinity of Candesartan, Losartan, Telmisartan and Valsartan with
           Angiotensin II Receptor 1 Subtype
    • Authors: Mohiuddin Ahmed Bhuiyan, Mohammad Shahriar, Takafumi Nagatomo
      Abstract: This study was designed to examine the interaction in the binding of selective angiotensin II receptor antagonists towards angiotensin II type 1 receptor. The AT1 antagonists used in this study were valsartan, candesartan and losartan. Wild type AT1 receptors were transiently expressed in COS-7 cells and the expressed protein was isolated. The binding affinities of agonist and these four AT1 antagonists were determined towards AT1 receptors with the help of radioligand binding studies. The binding affinity of candesartan has been found to be maximum having a pKi value of 8.61±0.21 whereas losartan showed lowest binding affinity among the antagonists (pKi=7.17±0.07). Telmisartan also showed high (pKi=8.19±0.04) and valsartan had moderate binding affinity (pKi=7.65±0.12) towards AT1 receptors. The results of the study suggested that candesartan interacts very strongly with the receptor which is consistent with the maximum number of binding sites of in the chemical structure of candesartan. On the other hand, losartan has lower number of binding sites with the amino acid residues of AT1 receptor and as a result it showed the minimum affinity towards the receptor.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 10-14, 2013
      PubDate: 2013-04-07
      Issue No: Vol. 16 (2013)
  • Fexofenadine HCl Immediate Release Tablets: In vitro Characterization and
           Evaluation of Excipients
    • Authors: Shahriar Ahmed, Mehrina Nazmi, Ikramul Hasan, Sabiha Sultana, Shimul Haldar, Md Selim Reza
      Abstract: Fexofenadine HCl immediate release tablets were designed to increase the dissolution rate by using superdisintegrants. Different formulations of Fexofenadine HCl were prepared by direct compression method. These formulations were evaluated for hardness, thickness, friability, weight variation, disintegration time, and in vitro dissolution study. The drug release from the formulations were studied according to USP specification (USP paddle method at 50 rpm for 60 minutes) maintaining the temperature to 37°C. Sodium starch glycolate, cross carmellose sodium, crospovidone (kollidon CL), ludiflash and xanthan gum were used in 3%, 6% and 8% concentrations as superdisintegrants. Thus, the ratio of superdisintegrants was changed whereas all the other excipients as well as the active drug (Fexofenadine HCl) remained same in every formulation. Here, 0.001N HCl was used as dissolution medium according to USP and absorbances were determined by using UV spectrophotometer at 217 nm. The F-3 and F-6 formulation prepared by 8% of Sodium starch glycolate and 8% of Cross carmellose sodium showed 99.99% drug release within 30 minutes and 45 minutes, respectively. The disintegration times of F-3 and F-6 formulation were within 9 seconds. The interactions between drug and excipients were characterized by FTIR spectroscopic study.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 1-9, 2013
      PubDate: 2013-04-07
      Issue No: Vol. 16 (2013)
  • Pharmacological and Phytochemical Screenings of Ethanol Extract of
           Etlingera linguiformis (Roxb.) R.M.Sm. Growing in Bangladesh
    • Authors: Md Arafat Hossan, Mohammed Ibrahim, Md Qamrul Ahsan, Fahima Aktar, Md Ruhul Kuddus, M Mohi Uddin Chowdhury, Mohammad A Rashid
      Abstract: The present study was conducted to investigate the bio-activities of ethanol extract of Etlingera linguiformis (Roxb.) R.M.Sm. as well as to determine the chemical profiles of the extract. The antibacterial and antifungal activities of the crude extract were evaluated by the disc diffusion method against 4 Gram positive and 7 Gram negative pathogenic bacteria and 7 fungi using Ciprofloxacin and Fluconazole as standards, respectively. The minimum inhibitory concentration (MIC) was determined by the serial dilution method. The anti-atherothrombosis activity was assessed by using Streptokinase (SK) as standard. Moreover, the in-vitro anti-inflammatory and membrane stablization tests were performed. In the anti-bacterial and antifungal activity test, the zones of inhibition were found within the range of 10.0-15.0 and 10.0-22.0 mm, respectively. The highest zone of inhibition was obtained against Bacillus cereus (15.0 mm) and Blastomyces dermatitidis (22.0 mm). In the minimum inhibitory concentration (MIC) test the crude extract inhibited the growth of Blastomyces dermatitidis significantly at 31.2 μg/ml. In the anti-atherothrombosis activity test, the extract revealed moderate clot lysis by 15.15%. Moreover, the extract produced inhibition of protein denaturation and haemolysis by 34% and 38.98% in the in vitro antiinflammatory and membrane stablization tests. Preliminary phytochemical screenings of the crude extractives demonstrated the presence of alkaloids, steroids, tannins, reducing sugars and gums. The extract also exhibited good biological activities. Therefore, the plant should be subjected to systematic bioactivity guided isolation in order to obtain the active molecules.
      DOI : Bangladesh Pharmaceutical Journal 16(1): 33-37, 2013
      PubDate: 2013-04-07
      Issue No: Vol. 16 (2013)
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