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Anwer Khan Modern Medical College J.     Open Access   (Followers: 2)
Asian J. of Medical and Biological Research     Open Access   (Followers: 3)
Bangabandhu Sheikh Mujib Medical University J.     Open Access   (Followers: 1)
Bangladesh Agronomy J.     Open Access   (Followers: 1)
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Bangladesh J. of Agricultural Research     Open Access   (Followers: 4)
Bangladesh J. of Anatomy     Open Access   (Followers: 1)
Bangladesh J. of Animal Science     Open Access   (Followers: 2)
Bangladesh J. of Bioethics     Open Access  
Bangladesh J. of Botany     Open Access   (SJR: 0.168, h-index: 10)
Bangladesh J. of Child Health     Open Access  
Bangladesh J. of Dental Research & Education     Open Access   (Followers: 2)
Bangladesh J. of Endosurgery     Open Access   (Followers: 2)
Bangladesh J. of Library and Information Science     Open Access   (Followers: 47)
Bangladesh J. of Medical Biochemistry     Open Access   (Followers: 3)
Bangladesh J. of Medical Education     Open Access   (Followers: 2)
Bangladesh J. of Medical Microbiology     Open Access   (Followers: 3)
Bangladesh J. of Medical Physics     Open Access  
Bangladesh J. of Medical Science     Open Access   (SJR: 0.147, h-index: 4)
Bangladesh J. of Medicine     Open Access   (Followers: 1)
Bangladesh J. of Nuclear Medicine     Open Access  
Bangladesh J. of Nutrition     Open Access   (Followers: 6)
Bangladesh J. of Orthodontics and Dentofacial Orthopedics     Open Access   (Followers: 3)
Bangladesh J. of Otorhinolaryngology     Open Access   (Followers: 1)
Bangladesh J. of Pharmacology     Open Access   (SJR: 0.283, h-index: 13)
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Bangladesh J. of Plant Breeding and Genetics     Open Access   (Followers: 5)
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Bangladesh J. of Plastic Surgery     Open Access   (Followers: 11)
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Bangladesh J. of Scientific Research     Open Access   (Followers: 1)
Bangladesh J. of Urology     Open Access   (Followers: 3)
Bangladesh J. of Veterinary Medicine     Open Access   (Followers: 2)
Bangladesh J. of Zoology     Open Access  
Bangladesh Medical J.     Open Access  
Bangladesh Medical J. Khulna     Open Access  
Bangladesh Pharmaceutical J.     Full-text available via subscription   (Followers: 1)
Bangladesh Rice J.     Open Access   (Followers: 2)
Bangladesh Veterinarian     Open Access  
BIRDEM Medical J.     Open Access   (Followers: 1)
Cardiovascular J.     Open Access   (Followers: 5)
Chattagram Maa-O-Shishu Hospital Medical College J.     Open Access  
Chemical Engineering Research Bulletin     Open Access   (Followers: 16, SJR: 0.152, h-index: 3)
Chittagong University J. of Biological Sciences     Open Access  
City Dental College J.     Open Access   (Followers: 1)
Community Based Medical J.     Open Access  
Delta Medical College J.     Open Access  
Dhaka University J. of Biological Sciences     Open Access  
Dhaka University J. of Pharmaceutical Sciences     Open Access   (Followers: 1, SJR: 0.225, h-index: 8)
Dhaka University J. of Science     Open Access  
Eastern Librarian     Open Access   (Followers: 11)
Faridpur Medical College J.     Open Access  
GANIT : J. of Bangladesh Mathematical Society     Open Access  
Ibrahim Cardiac Medical J.     Open Access  
Ibrahim Medical College J.     Open Access  
IMC J. of Medical Science     Open Access   (Followers: 10)
Intl. Current Pharmaceutical J.     Open Access  
Intl. J. of Agricultural Research, Innovation and Technology     Open Access   (Followers: 2)
Intl. J. of Natural Sciences     Open Access   (Followers: 1)
Intl. J. of Pharmaceutical and Life Sciences     Open Access   (Followers: 5)
J. of Advanced Veterinary and Animal Research     Open Access   (Followers: 6)
J. of Armed Forces Medical College, Bangladesh     Open Access  
J. of Bangladesh Society of Physiologist     Open Access  
J. of Bio-Science     Open Access   (Followers: 1, SJR: 0.106, h-index: 3)
J. of Business and Technology (Dhaka)     Open Access  
J. of Chemical Engineering     Open Access   (Followers: 25)
J. of Current and Advance Medical Research     Open Access   (Followers: 1)
J. of Dhaka Medical College     Open Access  
J. of Dhaka National Medical College & Hospital     Open Access  
J. of Enam Medical College     Open Access  
J. of Environmental Science and Natural Resources     Open Access   (Followers: 3)
J. of Life and Earth Science     Open Access  
J. of Mechanical Engineering     Open Access   (Followers: 53, SJR: 0.122, h-index: 2)
J. of Medicine     Open Access   (Followers: 1, SJR: 0.114, h-index: 1)
J. of National Institute of Neurosciences Bangladesh     Open Access  
J. of Naval Architecture and Marine Engineering     Open Access   (Followers: 4, SJR: 0.161, h-index: 2)
J. of Paediatric Surgeons of Bangladesh     Open Access  
J. of Science Foundation     Open Access   (Followers: 3)
J. of Scientific Research     Open Access  
J. of Shaheed Suhrawardy Medical College     Open Access  
J. of Surgical Sciences     Open Access   (Followers: 1)
J. of the Asiatic Society of Bangladesh, Science     Open Access  
J. of the Bangladesh Agricultural University     Open Access   (Followers: 1)
J. of the Bangladesh Association of Young Researchers     Open Access  
J. of the Bangladesh Chemical Society     Open Access  
J. of the Bangladesh Society of Anaesthesiologists     Open Access  
Jahangirnagar University Environmental Bulletin     Open Access  
Jahangirnagar University J. of Biological Sciences     Open Access  
KYAMC J.     Open Access  
Medicine Today     Open Access   (SJR: 0.116, h-index: 5)
Mediscope     Open Access   (Followers: 1)
Microbes and Health     Open Access   (Followers: 1)
Northern Intl. Medical College J.     Open Access  
Northern University J. of Law     Open Access  
Philosophy and Progress     Open Access  
Progressive Agriculture     Open Access   (Followers: 1)
Pulse : Medical J. of Apollo Hospitals Dhaka     Open Access  
Rajshahi University J. of Life & Earth and Agricultural Sciences     Open Access  
Research in Agriculture, Livestock and Fisheries     Open Access  
SAARC J. of Agriculture     Open Access  
South East Asia J. of Public Health     Open Access   (Followers: 3)
Stamford J. of English     Open Access   (Followers: 1)
Stamford J. of Microbiology     Open Access  
The Agriculturists     Open Access  
University Heart J.     Open Access  
University J. of Zoology, Rajshahi University     Open Access   (SJR: 0.101, h-index: 2)
Update Dental College J.     Open Access  

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Journal Cover Bangladesh Pharmaceutical Journal
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   Full-text available via subscription Subscription journal
   ISSN (Print) 0301-4606
   Published by Bangladesh Journals Online Homepage  [108 journals]
  • Evaluation of the Knowledge and Perceptions about Pharmacovigilance
           Activities among Pharmacy Students in Nigeria: A Cross-Sectional Study
    • Authors: Osemene Kanayo Patrick, Afolabi Margaret Olubunmi
      Pages: 1 - 13
      Abstract: Studies on pharmacovigilance (PV) activities in Nigeria focused on perceptions of PV among professional healthcare workers are described here. There is paucity of information on pharmacy students’ knowledge about PV activities. Hence, this study, evaluated the knowledge and perceptions of final year pharmacy students about PV activities using descriptive and inferential statistics. A cross sectional study was undertaken in three Nigerian universities with a pretested questionnaire during the period of January and February, 2016. The questionnaire included closed-ended questions on demographic variables and questions designed to achieve the objectives of the study. Data was analyzed with IBM SPSS Statistics 20 and presented in percentages, means, standard deviations and median at 50% percentile. The mean knowledge score of pharmacovigilance and adverse drug reporting for the final year students was 4.25±0.18. There were significant differences in the mean scores of knowledge domain by age groups 21-24 years 4.8±0.70, 25-30 years 6.2 ± 0.84 and >30 years 4.6±0.72 at p=0.001; gender: male 4.1±1.20 and female 4.4±0.98 at (p=0.0001) as well as the current universities attended as follows University 1 with a scrore of 5.1±1.03, University 2 had a mean score of 6.3±0.99 at p=0.0120 and University 3 with a mean score of 4.3±1.01 at p=0.012. Furthermore, significant difference exist in the mean values of pharmacovigilance knowledge between those who had taking some courses in pharmacovigilance (7.3± 0.22) and those who did not (4.7 ± 0.13) at p=0.0001. Generally, the students had inadequate knowledge of PV activities. Therefore, emphasis on relevant PV courses in their curriculum is necessary.Bangladesh Pharmaceutical Journal 20(1): 1-13, 2017
      PubDate: 2017-04-05
      DOI: 10.3329/bpj.v20i1.32082
      Issue No: Vol. 20, No. 1 (2017)
  • The Effects of Acute Stress on Memory, Attention and Cognition in Healthy
           Human Volunteers
    • Authors: Md Monir Hossain, Shahnaz Naznin, Dolly Sen, Mahnaz Hossain Fariba
      Pages: 14 - 19
      Abstract: The study was designed to investigate the effects of an acute naturalistic stressor, namely, examination of stress on memory, attention and cognition in healthy human volunteers. Fifty-three students participated in this study. All the volunteers were assessed for their neuropsychological states, which are memory, attention and cognition, during non-examination and examination period. The neuropsychological tests used in this study were- logical memory test, digit span test, letter cancellation test, trail making test and Stroop test. It was revealed that there was significant difference (p<0.05) in the score of logical memory II, backward and total score of digit span, time taken to complete letter cancellation test and score in part C of Stroop test in the exam period. The present study thus demonstrated that acute naturalistic stress improves attention while impairs delayed memory retrieval and cognition.Bangladesh Pharmaceutical Journal 20(1): 14-19, 2017
      PubDate: 2017-04-05
      DOI: 10.3329/bpj.v20i1.32088
      Issue No: Vol. 20, No. 1 (2017)
  • Identification and Quantification of Sodium Benzoate in Different Brands
           of Mango Juices Available in Tangail Region, Bangladesh
    • Authors: Shamoli Akter, Md Abu Zubair, Md Shahinul Haque Khan, Luthfunnesa Bari, Md Azizul Huq, Mohammad A Rashid
      Pages: 20 - 26
      Abstract: Chemical preservation has become an increasingly important practice in modern food technology. Sodium benzoate is a permitted food additive in restrictive amounts by international laws, but their content must be declared and must not exceed the established limits by legislation. An experimental study for the level of sodium benzoate in different brands of mango juices available in the markets, stores and shops in Tangail region of Bangladesh was determined by high performance liquid chromatography. A Luna 5 μ C18 (2) 100A column (250 × 4.6 mm) was used for the chromatographic analysis. Chromatographic separation was achieved with isocratic solvent system comprising of sodium acetate and acetic acid buffer (pH =4.0)/acetonitrile in the ratio of 80:20 (1 ml/min) at 37oC and the chromatograms were recorded at 254 nm. The limit of detection and quantification for sodium benzoate was 0.00076 mg/100 ml and 0.00231 mg/100 ml, respectively. Quantification of the selected brand juices revealed that the level of the used sodium benzoate was within the FDA standard range. But by comparing with the Bangladesh Standard and Testing Institute (BSTI), brand-1 and brand-3 of the analyzed juice samples was found to deviate the current legal limits. The percentage recovery was found to be 92.04 ± 1.98 to 98.01 ± 1.91. It was found that some of the brands used excess amount of sodium benzoate which may be harmful for our health.Bangladesh Pharmaceutical Journal 20(1): 20-26, 2017
      PubDate: 2017-04-05
      DOI: 10.3329/bpj.v20i1.32089
      Issue No: Vol. 20, No. 1 (2017)
  • Isolation and Biochemical Characterization of Lactobacillus species from
           Yogurt and Cheese samples in Dhaka Metropolitan Area
    • Authors: Sultana Juhara Mannan, Refaya Rezwan, Md Shajidur Rahman, Kohinur Begum
      Pages: 27 - 33
      Abstract: The purpose of this study was to explore Lactobacillus species from yogurt and cheese that can be used as potential probiotics. In this study, a total of twenty five samples, fifteen from cheese and ten from yogurt were collected from local markets, Dhaka city during May-July, 2016. Single colonies were isolated by enriching in MRS broth and subsequent streaking on MRS agar plate. Total twenty five isolated bacteria were identified as Lactobacillus species by morphological, gram staining and short biochemical tests. All isolated strains were characterized for probiotic properties including acid and salt tolerance, phenol tolerance, sugar fermentation, lactose fermentation and proteolytic activity. Acid tolerance test was performed at pH 2, 3, 4, 5, 6, 7 and 8 in MRS broth. Results showed all isolates survived in highly acidic pH, however most of the strains also survived in alkaline media (pH 8). Salt tolerance test was performed at 2%, 4% and 8% NaCl in MRS broth. All isolates survived in 2% and 4% NaCl concentrations. Phenol tolerance test was performed in MRS broth with 0.1%, 0.2%, 0.3% and 0.4% phenol concentration. All strains survived in 0.1% and 0.2% phenol concentrations. Sugars such as glucose, fructose, sucrose, xylose and lactose were used for fermentation tests. Results of fermentation test showed that most isolates fermented all sugars. All strains digested casein by producing protease enzyme in skim milk agar plate. This study indicated that Lactobacillus species from yogurt and cheese samples have potential probiotic properties. Further study is needed to find specific probiotics with specific benefit from yogurt and cheese.Bangladesh Pharmaceutical Journal 20(1): 27-33, 2017
      PubDate: 2017-04-05
      DOI: 10.3329/bpj.v20i1.32090
      Issue No: Vol. 20, No. 1 (2017)
  • Evaluation of Physical Properties of Selected Excipients for Direct
           Compressible Tablet
    • Authors: SM Moshiur Rahman, Tushar Saha, Zia Uddin Masum, Jakir Ahmed Chowdhury
      Pages: 34 - 38
      Abstract: Excipients play important roles in the manufacturing of direct compressible tablet. The physical properties of excipients like flow properties, bulk density, tapped density, compressibility and diameter of particles are the most important studies which should be taken under consideration. Excipients like lactose, ludipress, avicel, povidone, sodium starch glycolate, sodium lauryl sulfate, sodium carboxy methyl cellulose, polyethylene glycol 4000 (PEG 4000) and maize starch are used and found that PEG 4000, avicel PH-101, ludipress and sodium lauryl sulfate showed an angle of repose below 400 which indicates good flow properties and others are not. The highest compressibility value is obtained from lactose and compressibility value was lowest for PEG 4000. It was found from the average diameter of excipients that sodium starch glycolate is very fine graded powder because all particles pass through a sieve (100 mesh) and the highest value is obtained from PEG 4000.Bangladesh Pharmaceutical Journal 20(1): 34-38, 2017
      PubDate: 2017-04-05
      DOI: 10.3329/bpj.v20i1.32091
      Issue No: Vol. 20, No. 1 (2017)
  • In vivo CNS Depressant and Antinociceptive Studies of Microcos paniculata
           Stem Extracts on Animal Model
    • Authors: Md Anamul Haque, Md Anwarul Haque, Md Anwar Ul Islam
      Pages: 39 - 45
      Abstract: The main objective of the study was to evaluate the possible central nervous system (CNS) depressant and antinociceptive effects of methanol (MMPS), petroleum ether (PMPS), chloroform (CMPS), dichloromethane (DMPS) and aqueous (AMPS) extracts of the Microcos paniculata (M. paniculata). The CNS-depressant effect of different extracts of M. paniculata stem on Swiss albino mice was assessed by using open field, hole cross and head deep tests at 100 and 200 mg/kg dose. Analgesic effect was evaluated by acetic acid-induced writhing and hot plate methods at 100 and 200 mg/kg dose. All the extracts had exhibited significant (Pb < 0.01, Pa < 0.001) CNS depressant and analgesic effects in a dose dependant manner. MMPS had shown highest CNSdepressant effect with 93.39% inhibition of mice movement (open field), 78.92% inhibition of hole cross and 86.90% inhibition of head deeping at 200 mg/kg dose. Besides, DMPS extracts showed maximum analgesic effect with 75.52% inhibition of abdominal writhing and 65.55% elongation of paw licking time at 200mg/kg dose. Among the five extracts, MMPS possesses potent CNS depressant effect while DMPS possesses potent analgesic effect. These findings may expose effectiveness of the extracts on anxiety and pain that may help to formulate a herbal medicine or to search a lead compound.Bangladesh Pharmaceutical Journal 20(1): 39-45, 2017
      PubDate: 2017-04-05
      DOI: 10.3329/bpj.v20i1.32092
      Issue No: Vol. 20, No. 1 (2017)
  • Measuring the Impacts of Quality of Work Life Indicators on the Marketing
           Representatives of Pharmaceutical Industries
    • Authors: Kazi Nazmul Huda
      Pages: 46 - 53
      Abstract: In modern Human Resource Management (HRM) practice, the concept of ‘Quality of Work Life’ (QWL) is relatively a new strategy for employee retention. The idea of QWL is developed upon the increasing importance of reducing employee turnover rate in a highly competitive market. Better QWL practice in sales and marketing oriented companies is inevitable to ensure employee productivity and therefore needs to be studied in detail. The core objective of the study was to measure the impact of QWL variables on the lives of Marketing Representatives (MR) of pharmaceutical companies. First, the variables influencing QWL are elaborated with the help of extensive literature review. Then this study tried to identify the current scenario of QWL Practices in ten renowned pharmaceutical companies through a survey of 112 MRs. This was supplemented with in-depth interviews of HR executives of three different companies. The study discovered job stress as a high priority indicator of QWL. The research also revealed organizational atmosphere based on fairness, experience sharing culture, employee suggestion scheme, opportunity to use skill and satisfactory reward system as influential determinants of QWL. This paper recommends the installation of QWL practices in other pharmaceutical companies with few short and long-term suggestions. There is room for conceptualizing and actualizing standard QWL practice in the Bangladeshi pharmaceutical companies. An initiative like this one will encourage discussion and debates in applying much needed QWL practices in other sectors.Bangladesh Pharmaceutical Journal 20(1): 46-53, 2017
      PubDate: 2017-04-05
      DOI: 10.3329/bpj.v20i1.32093
      Issue No: Vol. 20, No. 1 (2017)
  • Release Kinetics Study of Azithromycin from Bi-layered Tablets
    • Authors: FM Shah Noman Ul Bari, Muhammad Rashedul Islam, Md Mizanur Rahman Moghal, Israt Jahan Ira
      Pages: 54 - 63
      Abstract: The objective of this study was to analysis in vitro release kinetics of Azithromycin from bi-layer tablets prepared by direct compression using high viscosity to low viscosity grades of hydroxypropyl methyl cellulose (HPMC K15M, HPMC K4M, HPMC 50 cps), Carbopol 934p and Carbopol 974p. In addition, it also includes evaluating the effect of formulation variables like polymer proportion and polymer viscosity on the release of Azithromycin. In vitro release studies were performed using USP Type-II (Rotating paddle method) at 100 rpm. The dissolution medium consisted of 0.1N HCl (900 ml) for the first 2 hr and the phosphate buffer (pH 6.0) from 3rd to 10th hour. From twenty five different formulations (F-1 to F-25) based on polymer variation, model-dependent and independent methods were used for data analysis and the best results were observed for HPMC 50cps in Korsmeyer- Peppas (R2=0.995 on F-23) kinetic model. The release mechanism of all formulations was Fickian.Bangladesh Pharmaceutical Journal 20(1): 54-63, 2017
      PubDate: 2017-04-05
      DOI: 10.3329/bpj.v20i1.32094
      Issue No: Vol. 20, No. 1 (2017)
  • Formulation Development and Characterization of Levosalbutamol Sulphate
           Oral Thin Film using Propylene glycol as a Plasticizer
    • Authors: Md Masud Morshed, Jewel Mallick, Fahamida Islam, Md Kamrul Islam, Md Didaruzzaman Sohel, Md Hassan Kawsar
      Pages: 64 - 70
      Abstract: The present study was concerned with the preparation and evaluation of oral thin films of levosalbutamol sulphate (LS) is to avoid presystemic elimination by gastrointestinal degradation and first pass hepatic metabolism. The films were prepared using four different water soluble polymers in various proportions and combinations using propylene glycol as plasticizers. Total five formulations were developed and evaluated for the various physicochemical characteristics namely mass uniformity, thickness, folding endurance, density, surface pH, swelling index, disintegration time, content uniformity, in vitro release profile, percent moisture absorption and loss and ex vivo mucoadhesion time. Data of every parameter were taken in triplicate. Results of film thickness, mass, density and swelling index of medicated films of LS were found with relatively low standard deviation along with high folding endurance (>300). The surface pH of all films approached to the salivary fluid pH range (6.1~7.0). Disintegration time and content uniformity complied with standard for all formulations. Among the total five formulations, F-2 and F-5 followed first order release and F-1 and F-4 followed Higuchi release and F-5 followed zero order and hixon-crowell release. The residence time for mucoadhesion of the tested films ranged between 1 to 5 minutes. Percent moisture absorption and loss study revealed the excellent stability of the films in dried conditions and relatively low standard deviation indicated the stability also in humid conditions.Bangladesh Pharmaceutical Journal 20(1): 64-70, 2017
      PubDate: 2017-04-05
      DOI: 10.3329/bpj.v20i1.32095
      Issue No: Vol. 20, No. 1 (2017)
  • In Silico Virulence and Resistance Profile Analysis of Staphylococcus
    • Authors: Nusrat Nahar, Ridwan Bin Rashid, ANM Hamidul Kabir, Mohammad Sharifur Rahman
      Pages: 71 - 84
      Abstract: In silico studies of the genes of Staphylococcus spp. might establish some correlations with multiple pathological factors. Sixty isolates of Staphylococcus spp. have been studied here targeting virulence and antibiotic resistance genes through in silico tools. Here, in silico PCR (polymerase chain reaction) amplification detected both virulence and antibiotic resistance genes. Study revealed that most of the isolates harboured either cap5 (40%) or cap8 (31.67%) locus gene. Staphylococcal enterotoxin was detected in 63.33% of the isolates. The sea gene, responsible for food poisoning, was detected in 26.67% of the isolates. The tst positive isolates (5%), responsible for toxic shock syndrome, were present in only genotype 8. No exfoliative toxin was detected. The icaA gene, responsible for intracellular adherence, appeared in 80% of the isolates. Alpha hemolysin gene, hla, was detected in 63.33% of the isolates. Sixty-five percent of the isolates harboured the mecA genes. Both β-lactamase (blaZ) and erythromycin resistance, ermA genes were available in 38.33% of the isolates. In silico pulsed field gel electrophoresis (PFGE) digestion was able to divide isolates into 23 genotypes. Genotype 8 and 11 harboured tetracycline resistance genes, tetM and tetK. The tetM gene (18.33%) was more prevalent than tetK gene (11.67%). Genotype 1 and 11 were considered more virulent than others. Genotype 11 also carried six antibiotic resistance genes but did not carry the genes msrA, msrB, ermB and ermC. The data generated here might aid in the prediction of the virulence and resistance profile based on genotyping as well as contribute in vaccine development.Bangladesh Pharmaceutical Journal 20(1): 71-84, 2017
      PubDate: 2017-04-05
      DOI: 10.3329/bpj.v20i1.32096
      Issue No: Vol. 20, No. 1 (2017)
  • Pharmacological Investigation on Ethanol Extract of Scindapsus hederaceus
    • Authors: Md Mazharul Islam, Mohammed Ibrahim, Mohiminul Adib, Syed Mohammed Tareq, Mohammad Rashedul Haque, Mohammad A Rashid
      Pages: 85 - 89
      Abstract: The present study was conducted to evaluate the antipyretic, anti-inflammatory and membrane stabilizing, antioxidant, thrombolytic, anti-diarrheal activities of Scindapsu shederaceus belonging to the Araceae family. In antipyretic test, temperature reduced from 101.53°F to 99.86°F (p<0.05), 99.20°F (p<0.05) and 99.06°F (p<0.05) in 1st, 2nd and 3rd hour, respectively and caused maximum reduction of temperature in 1st hour. In the hot plate method, the extract increased the reaction time of heat sensation significantly to 14.32 seconds. In in vitro anti-inflammatory test, the extract significantly inhibited protein denaturation by 85.17% at 500 μg/ml, 71.72% at 250 μg/ml and by 66.55% at 125 μg/ml. It also inhibited the hypotonic solution-induced haemolysis by 73.19%, 49.69% and 29.15% at same concentration in membrane stabilizing assay. In DPPH inhibition assay the extract showed maximum % inhibition of 65.5% at 100 μg/ml. In the assay of thrombolytic activity, the extract showed thrombolytic activity of 14.39%. Amylase inhibitory activity was found to be 22.38% at a concentration 100 μg/ml. In case of antidiarrheal investigation, the extract reveled total inhibition of defection by 35.30%.Bangladesh Pharmaceutical Journal 20(1): 85-89, 2017
      PubDate: 2017-04-05
      DOI: 10.3329/bpj.v20i1.32097
      Issue No: Vol. 20, No. 1 (2017)
  • Improving Micromeritic Properties of Ibuprofen: An Agglomeration Approach
    • Authors: Md Sazzadul Islam, Md Saiful Islam Pathan
      Pages: 90 - 98
      Abstract: Ibuprofen is one of the common NSAIDs having poor water solubility, low dissolution, weak flow properties and reduced compressibility. These downsides of ibuprofen crystal upraise crucial challenges during development of a dosage form. The aim of this present work was to modify the physical form of ibuprofen by changing micromeritic properties. Seven different formulations of ibuprofen agglomerates such as F-1, F-2, F-3, F-4, F-5, F-6 and F-7 were prepared to convert the needle shaped ibuprofen crystals into agglomerates so that the desired micromeritic properties can be achieved. In this study, agglomerates of ibuprofen were prepared by Quasi emulsion solvent diffusion (QESD) method in association with two surfactants (sodium lauryl sulphateand Tween 80) at three different concentrations for each. The micromeritic properties of the prepared agglomerates were evaluated for bulk density, tapped density, Carr’s index, Hausner’s ratio, angle of repose along with the release behavior of agglomerates. From dissolution study, it was observed that the release of drug was directly proportional to the surfactant concentration. Here, it was also revealed that there was no interaction among ibuprofen and other excipients as evident from DSC and FTIR studies.Bangladesh Pharmaceutical Journal 20(1): 90-98, 2017
      PubDate: 2017-04-05
      DOI: 10.3329/bpj.v20i1.32098
      Issue No: Vol. 20, No. 1 (2017)
  • Applications of Aptamers in Medicine: A Mini Review
    • Authors: Nusrat Nahar, Ridwan Bin Rashid, Mohammad Sharifur Rahman
      Pages: 99 - 104
      Abstract: Aptamers are single-stranded DNA or RNA molecules that bind to its target with high affinity and specificity. Nucleic acid aptamers are an attractive class of carrier molecules because of their tissue penetration capability, high chemical flexibility, low immunogenicity, low toxicity and cost effective production. These characteristics make aptamers an alternative to the antibody. An aptamer can be developed for the treatment of age-related macular degeneracy disease, blood clotting, cancer and auto-immune diseases etc. Macugen is so far the only aptamer-based drug that received FDA approval. Cancer patients are treated by targeting two proteins named nucleolin and CXCL12. Targeted delivery of aptamers has been successfully developed that reduce the occurrence of the unwanted off-target effects. Aptamers are susceptible to renal filtration and endonuclease cleavage. Conjugation with PEG or cholesterol and chemical modification can decrease renal clearance and increase serum stability.Bangladesh Pharmaceutical Journal 20(1): 99-104, 2017
      PubDate: 2017-04-05
      DOI: 10.3329/bpj.v20i1.32099
      Issue No: Vol. 20, No. 1 (2017)
  • Review on Pharmacovigilance Practice for Safety of Medication System in
    • Authors: Nusrat Jahan, Md Akter Hossain, Md Aslam Hossain, Md Shah Amran
      Pages: 105 - 114
      Abstract: Pharmacovigilance is a system that provides safety to the patients in case of medication. It mainly deals with adverse drug reactions. With the outbreak of new diseases new medicines are developing worldwide. So to ensure the safety of drug, pharmacovigilance is very necessary. National pharmacovigilance center of a country coordinates the overall activity of pharmacovigilance in collaboration with international regulatory authorities like WHO, the Uppsala Monitoring Centre etc. Integration of pharmacovigilance system in public health has positive impact on improvement of health care system. In Bangladesh Directorate General of Drug Administration (DGDA) is playing an active role to ensure the safety of medication system.Bangladesh Pharmaceutical Journal 20(1): 105-114, 2017
      PubDate: 2017-04-05
      DOI: 10.3329/bpj.v20i1.32100
      Issue No: Vol. 20, No. 1 (2017)
  • Recent Health Issues Vol 20(1)
    • Authors: Md Akbar Hossain
      First page: 115
      Abstract: not availableBangladesh Pharmaceutical Journal 20(1): 115, 2017
      PubDate: 2017-04-05
      DOI: 10.3329/bpj.v20i1.32101
      Issue No: Vol. 20, No. 1 (2017)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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