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Publisher: Bangladesh Journals Online   (Total: 108 journals)

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Anwer Khan Modern Medical College J.     Open Access   (Followers: 1)
Asian J. of Medical and Biological Research     Open Access   (Followers: 1)
Bangabandhu Sheikh Mujib Medical University J.     Open Access  
Bangladesh Agronomy J.     Open Access  
Bangladesh Critical Care J.     Open Access   (Followers: 1)
Bangladesh Heart J.     Open Access  
Bangladesh J. of Agricultural Research     Open Access   (Followers: 3)
Bangladesh J. of Anatomy     Open Access   (Followers: 1)
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Bangladesh J. of Bioethics     Open Access  
Bangladesh J. of Botany     Open Access   (SJR: 0.226, h-index: 9)
Bangladesh J. of Child Health     Open Access  
Bangladesh J. of Dental Research & Education     Open Access  
Bangladesh J. of Endosurgery     Open Access   (Followers: 2)
Bangladesh J. of Library and Information Science     Open Access   (Followers: 37)
Bangladesh J. of Medical Biochemistry     Open Access   (Followers: 2)
Bangladesh J. of Medical Education     Open Access   (Followers: 1)
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Bangladesh J. of Medical Science     Open Access   (SJR: 0.21, h-index: 3)
Bangladesh J. of Medicine     Open Access   (Followers: 1)
Bangladesh J. of Nuclear Medicine     Open Access  
Bangladesh J. of Nutrition     Open Access   (Followers: 5)
Bangladesh J. of Orthodontics and Dentofacial Orthopedics     Open Access   (Followers: 3)
Bangladesh J. of Otorhinolaryngology     Open Access  
Bangladesh J. of Pharmacology     Open Access   (SJR: 0.243, h-index: 10)
Bangladesh J. of Physiology and Pharmacology     Open Access  
Bangladesh J. of Plant Breeding and Genetics     Open Access   (Followers: 4)
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Bangladesh J. of Urology     Open Access   (Followers: 3)
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Bangladesh Medical J.     Open Access  
Bangladesh Medical J. Khulna     Open Access  
Bangladesh Medical Research Council Bulletin     Open Access   (SJR: 0.295, h-index: 13)
Bangladesh Pharmaceutical J.     Full-text available via subscription   (Followers: 1)
Bangladesh Rice J.     Open Access  
Bangladesh Veterinarian     Open Access  
BIRDEM Medical J.     Open Access   (Followers: 1)
Cardiovascular J.     Open Access   (Followers: 4)
Chattagram Maa-O-Shishu Hospital Medical College J.     Open Access  
Chemical Engineering Research Bulletin     Open Access   (Followers: 8, SJR: 0.207, h-index: 2)
Chittagong University J. of Biological Sciences     Open Access  
City Dental College J.     Open Access   (Followers: 1)
Community Based Medical J.     Open Access  
Delta Medical College J.     Open Access  
Dhaka University J. of Biological Sciences     Open Access  
Dhaka University J. of Pharmaceutical Sciences     Open Access   (Followers: 1, SJR: 0.171, h-index: 6)
Dhaka University J. of Science     Open Access  
Eastern Librarian     Open Access   (Followers: 10)
Faridpur Medical College J.     Open Access  
GANIT : J. of Bangladesh Mathematical Society     Open Access  
Ibrahim Cardiac Medical J.     Open Access  
Ibrahim Medical College J.     Open Access  
Intl. Current Pharmaceutical J.     Open Access   (Followers: 1)
Intl. J. of Agricultural Research, Innovation and Technology     Open Access   (Followers: 2)
Intl. J. of Natural Sciences     Open Access   (Followers: 1)
Intl. J. of Pharmaceutical and Life Sciences     Open Access   (Followers: 5)
J. of Advanced Veterinary and Animal Research     Open Access   (Followers: 5)
J. of Armed Forces Medical College, Bangladesh     Open Access  
J. of Bangladesh Society of Physiologist     Open Access  
J. of Bio-Science     Open Access   (Followers: 1, SJR: 0.103, h-index: 2)
J. of Business and Technology (Dhaka)     Open Access  
J. of Chemical Engineering     Open Access   (Followers: 13)
J. of Current and Advance Medical Research     Open Access   (Followers: 1)
J. of Dhaka Medical College     Open Access  
J. of Dhaka National Medical College & Hospital     Open Access  
J. of Enam Medical College     Open Access  
J. of Environmental Science and Natural Resources     Open Access   (Followers: 2)
J. of Life and Earth Science     Open Access  
J. of Mechanical Engineering     Open Access   (Followers: 28, SJR: 0.11, h-index: 1)
J. of Medicine     Open Access   (Followers: 1, SJR: 0.111, h-index: 22)
J. of National Institute of Neurosciences Bangladesh     Open Access  
J. of Naval Architecture and Marine Engineering     Open Access   (Followers: 3)
J. of Paediatric Surgeons of Bangladesh     Open Access  
J. of Science Foundation     Open Access   (Followers: 3)
J. of Scientific Research     Open Access  
J. of Shaheed Suhrawardy Medical College     Open Access  
J. of Surgical Sciences     Open Access  
J. of the Asiatic Society of Bangladesh, Science     Open Access  
J. of the Bangladesh Agricultural University     Open Access  
J. of the Bangladesh Association of Young Researchers     Open Access  
J. of the Bangladesh Chemical Society     Open Access  
J. of the Bangladesh Society of Anaesthesiologists     Open Access  
Jahangirnagar University Environmental Bulletin     Open Access  
Jahangirnagar University J. of Biological Sciences     Open Access  
KYAMC J.     Open Access  
Medicine Today     Open Access   (SJR: 0.188, h-index: 5)
Mediscope     Open Access   (Followers: 1)
Microbes and Health     Open Access   (Followers: 1)
Northern Intl. Medical College J.     Open Access  
Northern University J. of Law     Open Access  
Philosophy and Progress     Open Access  
Progressive Agriculture     Open Access   (Followers: 1)
Pulse : Medical J. of Apollo Hospitals Dhaka     Open Access  
Rajshahi University J. of Life & Earth and Agricultural Sciences     Open Access  
Research in Agriculture, Livestock and Fisheries     Open Access  
SAARC J. of Agriculture     Open Access  
South East Asia J. of Public Health     Open Access   (Followers: 2)
Stamford J. of English     Open Access   (Followers: 1)
Stamford J. of Microbiology     Open Access  
The Agriculturists     Open Access  
University Heart J.     Open Access  
University J. of Zoology, Rajshahi University     Open Access   (SJR: 0.102, h-index: 2)
Update Dental College J.     Open Access  

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Journal Cover Bangladesh Pharmaceutical Journal
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   Full-text available via subscription Subscription journal
   ISSN (Print) 0301-4606
   Published by Bangladesh Journals Online Homepage  [108 journals]
  • Preparation and Evaluation of Ornidazole Periodontal Films
    • Authors: Jayera Islam Urmi, Marzia Alam, Md Saiful Islam Pathan
      Pages: 133 - 146
      Abstract: Periodontitis is a local infection in the gingival crevices, which affects the structural organs surrounding the teeth like periodontal ligament, connective tissue and bone. Ornidazole is an antimicrobial drug widely used to treat periodontitis. The primary objective of this study was to design and evaluate periodontal films of ornidazole for placement into the periodontal pockets for targeted delivery of drug. Nine formulations (F1 to F9) were prepared by solvent casting method using polymer A, polymer B and plasticizer A. Chloroform and dichloromethane were used as solvent system. The API and dental films were then evaluated for various parameters including trinocular microscopic image, melting point, weight variation, thickness, folding endurance, surface pH, swelling index, percentage moisture loss, antimicrobial activity, content uniformity, in vitro drug release and release kinetics as well as RTIR and DSC. Formulation F1 showed the minimum weight and thickness and F9 showed the maximum. It was observed that weight and thickness of film were directly proportional to the total solid content of the film. RSDs of content uniformity test for all the batches were below 3.0%. Folding endurance and swelling index of films were inversely proportional to the amount of polymer in the film. The surface pH of all the batches were between 6-7. Formulation F1 revealed the maximum percentage of moisture loss (19.34%), while F8 showed the minimum (3.654%). Formulation F2 demonstrated data the highest zone of inhibition (21.91 mm).Bangladesh Pharmaceutical Journal 19(2): 133-146, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Antioxidant and Membrane Stabilizing Activities of Bark of Sonneratia
           apetala
    • Authors: Md Emdadul Hasan Mukul, Mohammad Salim Hossain, Sayed Koushik Ahamed, Pankaj Debnath, Mariyam Akter
      Pages: 147 - 151
      Abstract: This study was carried out to investigate the antioxidant activity in terms of free radical scavenging capacity and membrane stabilizing ability of methanol extract of bark of Sonneratia apetala. The total phenol content of the extract was measured by Folin-Ciocalteu reagent. The antioxidant potential was investigated using 2,2 diphenylpicrylhydrazyl (DPPH), reducing power assay and chelating power determination. The membrane stabilizing capacity was assessed by monitoring the hypotonic solution - and heat-induced haemolysis of human erythrocytes. The total phenolic content was found 50.75 mg/gm of gallic acid equivalent. The extract exhibited significant antioxidant activity in DPPH free radical scavenging assay with IC50 value of 81.42 µg/ml as compared to the standard, BHT (IC50=42.56 µg/ml), Fe2+ ion reducing power assay and chelating power ability. In case of assay for chelating ability, EDTA represented 98.76% chelation while the plant extract showed 82.83% at concentration of 100 μg/ml. In addition, the methanol extract of bark of this plant was found to moderately inhibit the haemolysis of human erythrocyte. In conclusion, the methanol extract of S. apetala could be valuable candidate for future development for antioxidant activity.Bangladesh Pharmaceutical Journal 19(2): 147-151, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Formulation and Optimization of Carbamazepine Microspheres by 2 Factor 2
           Level Central Composite Design
    • Authors: Nusrat Ahmed, Ikramul Hasan, Mohammad Saifuddin, Jakir Ahmed Chowdhury, Md Selim Reza
      Pages: 152 - 160
      Abstract: The present investigation was designed to prepare controlled release microspheres of carbamazepine using two polymers of different solubility and permeability characteristics, Ethocel standard 45 premium and Eudragit RL 100. The drug release profile was optimized with the aid of design of experiments (DoE). Microspheres of combined polymers were designed according to 22 factorial central composite design (CCD), taking drug loading and polymeric ratio as the independent variables. Total thirteen batches were prepared. The dependent variables were percentage of drug released in 3 hours and 6 hours and mean dissolution time (MDT). The regression parameters of the developed model and graphical interpretation for each response with statistical significance were calculated by using Minitab 17. The relationship between the experimental variables and responses were evaluated by generating response surface plots. Increased amount of Eudragit RL 100 had impact on surface morphology of prepared microspheres. It produced larger holes on the surface due to its higher permeability characteristics. Polynomial mathematical models generated for various response variables using multiple linear regression analysis, were found to be statistically significant (p < 0.05). One optimum formulation (O1) was selected based on USP specification and the second optimum formulation (O2) was selected for the maximization of MDT (hours). Batch O1 showed 22.85 % and 48.78 % drug release after 3 and 6 hours, respectively which were found to be in close agreement with those predicted by the mathematical model. Another optimum formulation, batch O2 showed MDT as 160.61 hours.Bangladesh Pharmaceutical Journal 19(2): 152-160, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Cytotoxic, Membrane Stabilizing and Anti-diarrheal Activities of Bambusa
           bambos Linn.
    • Authors: Ridwan Bin Rashid, Sharmin Khandker Shampa, Md Al Faruk, Mohiminul Adib, Mohammad Firoz Khan
      Pages: 161 - 165
      Abstract: Bambusa bambos Linn., a herbal medicine belonging to the family Poaceae, is locally known as Kanta bans or only bans. The crude methanolic extract of leaves of B. bambos and its different partitionates were evaluated for in vitro cytotoxicity, membrane stabilizing and anti-diarrheal activities. In the cytotoxicity screening, the dichloromethane and pet ether soluble fractions displayed the highest lethality to brine shrimps with LC50 of 3.91 and 8.45μg/ml, respectively, whereas the standard vincristine sulphate had LC50 value of 0.45μg/ml. In the membrane stabilizing assay, the crude methanolic extract exhibited highest inhibition of haemolysis of human RBCs by 71.08 ± 0.43% and 49.44 ± 0.73% in heat- and hypotonic solution-induced haemolysis, respectively. The extract exhibited significant (p < 0.05) anti-diarrheal effect at a dose of 400 mg/kg body weight in the castor oil induced anti-diarrheal assay.Bangladesh Pharmaceutical Journal 19(2): 161-165, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Flavonoid and Steroids from Polygonum viscosum
    • Authors: Bidyut Kanti Datta, Tahamina Iasmin, Mohammad A Rashid
      Pages: 166 - 169
      Abstract: Repeated chromatographic separation and purification of the n-hexane-ethyl acetate (3:1) extract of aerial parts of Polygonum viscosum provided a flavonoid- ternatin (1) and two steroids- stigmasterol (2) and stigmasta-4,22-dien-3-one (3). The structure of these compounds were determined on the basis of extensive NMR and other spectroscopic techniques and comparison with published data. The identity of steroids 2 and 3 was confirmed by co-TLC with authentic sample.Bangladesh Pharmaceutical Journal 19(2): 166-169, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Computational Study of Geometry, IR Spectrum and Molecular Properties of
           Acetanilide
    • Authors: Mohammad Firoz Khan, Rahatullah Razan, Ridwan Bin Rashid, Faiza Tahia, Mohammad A Rashid
      Pages: 170 - 178
      Abstract: In this paper an effort has made to conduct and repot the computational study of geometry, IR spectrum and different molecular properties like Molecular Electrostatic Potential (MESP), Mulliken Charge Distribution, Global Reactivity Descriptors such as chemical hardness, softness, chemical potential, electronegativity, and electrophilicity index of acetanilide. All calculations were performed on Hartee-Fock (HF), Becke and 3-parameter, Lee-Yang-Parr (B3LYP) with 6-31G(d) and 6-31+G(d,p) basis sets. The calculated geometries (bond length, bond angle and dihedral angle) were in a good agreement with the experimental data for both level of theories and basis sets. In case of IR frequencies the scaled calculated frequencies agreed reasonably well with the experimental results.Bangladesh Pharmaceutical Journal 19(2): 170-178, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Prevalence and Risk Factors of Obesity and Hypertension Among University
           Students in Rajshahi City, Bangladesh
    • Authors: Md Uzzal Haque, SK Benozir Ahmmed, Md Khokon Miah Akanda, Md Tarek Hasan, Sumaiya Akter Mou, Sadiur Rahman Sajon, Md Anwar Ul Islam
      Pages: 179 - 184
      Abstract: Obesity has become a new challenge for health care providers in the world, which leads to reduced life expectancy or increased health problems. The aim of the present study was to assess the prevalence and risk factors of obesity and hypertension among the undergraduate and postgraduate students in Rajshahi city. About 675 students were interviewed by standard questionnaires with their verbal consents. In this study, we found that a major portion of the population (13.93% which is about 94 students out of 675) were overweight and 61 students (9.04%) were obese at different stages on the basis of Body Mass Index (BMI) values where 75.41% and 31.15% were male and female students, respectively. About 31.15% of the obese students came from families with monthly income of 31000-40000 taka and 29.50% obese students have at least one obese parent. We also observed that about 32 students (52.46%) out of 61 obese students were pre-hypertensive and 34.43% obese students were stage I hypertensive patient. In this study, we found that the most common risk factors of obesity and hypertension among university students were sedentary life style, physical activity less than 30 min/day, smoking, frequent intake of soft drinks, fast food and food rich in fats (Junk food). This may be the first health survey conducted regarding obesity and hypertension among these university students in Bangladesh, which might be helpful for health workers to raise awareness among the mass people.Bangladesh Pharmaceutical Journal 19(2): 179-184, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • In vitro Membrane Stabilizing and In vivo Analgesic Activities of
           Boehmeria glomerulifera Miq. in Swiss-Albino Mice Model
    • Authors: Sabikunnahar Papia, Muhammed Mahfuzur Rahman, Md Mustafezur Rahman, Mohaiminul Adib, Mohammad Firoz Khan
      Pages: 185 - 189
      Abstract: Boehmeria glomerulifera Miq. is an indigenous plant of Bangladesh. Traditional healers use this plant to treat various diseases. The crude methanol extract of whole plant of B. glomerulifera and its Kupchan fractions were screened for in vitro membrane stabilizing and only the crude extract at doses of 200- and 400- mg/kg body weight were screened for analgesic activity in mice model in order to establish the medicinal values of this plant. The membrane stabilizing activity of the extractives was evaluated by the ability of test materials to inhibit hypotonic solution- and heat-induced haemolysis of human erythrocytes. Moreover, the analgesic activity of methanol extract was evaluated by acetic acid induced writhing method and tail immersion method in mice. In hypotonic solution- and heat-induced conditions, the crude methanol extract showed inhibition of haemolysis by 64.80±0.34% and 21.63±0.76%, respectively as compared to 77.74±0.67% and 40.41±0.69% demonstrated by the standard, acetyl salicylic acid. On the other hand, the analgesic activity was determined for its peripheral and central pharmacological responses using acetic acid-induced writhing test and tail immersion method at doses of 200- and 400- mg/kg body weight. The extract reduced the acetic acid-induced writhings significantly (p < 0.05) in a dose dependent manner with the highest activity observed at 400 mg/kg (46.0%) body weight when compared to that of Diclofenac sodium (64.0%), as the standard drug. A significant increase (p < 0.01) of latency period was also found in tail immersion method. Therefore, the present study established that the methanol extract of B. glomerulifera possesses moderate membrane stabilizing and significant analgesic activities.Bangladesh Pharmaceutical Journal 19(2): 185-189, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Prevention of Cap-Locking of Syrup Product by Treating the Manufacturing
           Process of Sugar Syrup with Citric Acid Monohydrate
    • Authors: Mia Mohammad Dulal, Md Kaisarul Islam, Abu Asad Chowdhury, Jakir Ahmed Chowdhury
      Pages: 190 - 196
      Abstract: The aim of the study was to prevent crystallization of sucrose on the bottle neck and cap of sugar syrup containing products by treating the manufacturing process with citric acid monohydrate. Diphenhydramine HCl syrup was selected as a model product for the experiment. Sugar syrup (66% w/w sucrose) and partially inverted sugar syrup (in which 66% w/w sucrose was treated with citric acid monohydrate for partially conversion of sucrose into invert sugars) were prepared and the content of invert sugar of both the sugar syrups were determined. Sugar syrup and citric acid monohydrate treated sugar syrup (partially inverted) were considered as control and test sugar syrup, respectively which were used to manufacture the Diphenhydramine HCl syrup product. The Diphenhydramine HCl syrup product that prepared using sugar syrup was considered as control syrup product and that was prepared using citric acid monohydrate treated sugar syrup (partially inverted) was considered as the test syrup product. Then experiments were designed in such a way that both control (sugar syrup and product prepared by it) and test samples (partially inverted syrup and product prepared by it) were spread on open petridishes and also spread on the neck of filled bottle, inside of caps and the bottles, which were kept at room temperature (25 0C) for 2 weeks observation. At zero time and after two weeks, crystal growths of sucrose for each experiment were checked visually. No crystal was observed in open petridishes and bottle necks of partially inverted sugar syrup of Diphenhydramine HCl syrup prepared by using partially inverted sugar syrup, where content of invert sugars was more than 75 % w/w, but remarkable crystal growths were found in open petridishes and bottle necks of sugar syrup and Diphenhydramine HCl syrup prepared by using sugar syrup, where the content of invert sugars was less than 15 % w/w.Bangladesh Pharmaceutical Journal 19(2): 190-196, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Study of Interaction of Dextromethorphan Hydrobromide with
           Deoxyribonucleic Acid by Fluorescence Quenching
    • Authors: Toufiq Ul Amin, Md Reazul Islam, Md Zakir Sultan, Sonia Sultana, Md Saiful Islam, Abul Hasnat
      Pages: 197 - 205
      Abstract: Interactions with many clinically active therapeutic agents with deoxyribonucleic acid (DNA) are well studied and it expedites deciphering the structure of DNA and to investigate the pathological implication of those molecules in a living organism. The interaction of dextromethorphan hydrobromide (DEX) with calf thymus DNA (ct DNA) was studied employing UV absorption and fluorescence spectroscopic techniques. The binding affinity of DEX to DNA was calculated at different temperatures and the stoichiometry of binding was characterized to be about 1 dextromethorphan molecule per nucleotide. Hypochromic effect was found in the absorption spectra of dextromethorphan, and its wavelength had no shift in the presence of DNA indicating external binding mode of dextromethorphan to DNA. Quenching constants 3532 L/ mol and 12446L/ mol at 298 K and 308 K respectively with correlation co-efficient of 0.974 and 0.976, using Stern-Volmer equation and the quenching mechanism was found to be dynamic. Fluorescence spectroscopic results showed the quenching of fluorescence intensity of DEX in the presence of DNA, indicating the interaction between DEX and DNA. Based on this, hydrophobic interaction were found to play the dominating role in DEX-DNA binding and those binding forces also indicate the binding site of dextromethorphan to be in the minor groove of DNA.Bangladesh Pharmaceutical Journal 19(2): 197-205, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Detection of Escherichia coli in Drinking Water Sources of Filter Units
           and Supply Water
    • Authors: Arman Chowdhory, Nafisa Kabir, Md Mazharul Islam Chowdhury, Jakir Ahmed Chowdhury
      Pages: 206 - 210
      Abstract: The identification of coliforms has been extensively used as an indicator of drinking water quality. The study was aimed to identify the presence or absence of E. coli from drinking water. Samples were collected from different filtration units and tap water sources of an institution in Dhaka city. All the samples were tested through presumptive, confirmed and completed bacteriological test through MPN (most probable number) using 3 sets of lactose broth (LB) media and MF (membrane filtration) technique using bacteriological filter and nutrient agar media to find out the CFU (colony forming unit). About 10% of samples showed positive results for E. coli in completed test, and also gave positive results in confirmed test and gram staining; having no more than 1100 MPN per 100 ml for samples of filter taps but the source water remained negative.Bangladesh Pharmaceutical Journal 19(2): 206-210, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Synthesis, Characterization and Antimicrobial Studies of Schiff Base
           Ligand-Derived from Amoxicillin and Benzaldehyde
    • Authors: Asif Iqbal, Farhana Hoque
      Pages: 211 - 214
      Abstract: Advanced research into synthetic chemistry has pointed out several organic compounds with antimicrobial potential. Schiff bases are one of such compounds. This research aims at the synthesis of a Schiff base out of a fairly common antibiotic amoxicillin and benzaldehyde. The synthesized compound was characterized by different spectroscopic techniques. It was also subjected to melting point determination, TLC and solubility tests. The Schiff base was screened for antibacterial and antifungal activities in-vitro by disc diffusion method.Bangladesh Pharmaceutical Journal 19(2): 211-214, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Analgesic and Antidiarrheal Activities of Leaf of Podocarpus neriifolius
           D. Don
    • Authors: Md Rahatullah Razan, Muhammed Mahfuzur Rahman, Faiza Tahia, Md Khalid Hossain, Mohammad A Rashid
      Pages: 215 - 218
      Abstract: The methanol extract of leaf of Podocarpus neriifolius D. Don exhibited in vivo peripheral analgesic and antidiarrheal activities in Swiss Albino mice. In the peripheral analgesic activity assay, the methanolic extract showed 50.00 ± 8.57% and 70.25 ± 1.18% inhibition of acetic acid-induced writhing at 200 and 400 mg/kg body weight, respectively. In addition, the extract also revealed a dose dependant inhibition of castor oil- induced diarrhea with 43.77 ± 3.13% and 56.23 ± 6.49% inhibition of feces at 200 and 400 mg/kg body weight, respectivelyBangladesh Pharmaceutical Journal 19(2): 215-218, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Release Modification of Indomethacin Controlled Release Press Coated
           Tablets
    • Authors: Muhammad Rashedul Islam, Md Elias al Mamun, Md Mizanur Rahman Moghal
      Pages: 219 - 225
      Abstract: The study was carried out to evaluate the release modification of indomethacin press coated tablets through different polymers. Several batches of press coated tablets were prepared with indomethacin and Avicel PH 102. The core tablet was compression coated with minimal compression pressure. Formulation IX was modified by incorporating PEG 6000, sodium chloride and sodium lauryl sulphate (SLS). In vitro dissolution studies of the formulations of different excipients were done at pH 7.2 in phosphate buffer using USP apparatus 2 (paddle method) at 50 rpm and 37 ± 0.5 °C temperature. The drug release data was treated in different mathematical fashion to identify the kinetic behaviour. It was found that, drug release which was inversely proportional to the amount of xanthan gum in the coating formulations was significantly changed by the polymers used in the study. Incorporation of SLS caused the drug to be released in near zero order fashion. Drug release was found to follow Higuchi mechanism for all the formulations. The study reveals that the polymers used may be a significant factor for the discrepancy in release rate of indomethacin.Bangladesh Pharmaceutical Journal 19(2): 219-225, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Evaluation of Thrombolytic, Membrane Stabilizing, Antidiarrhoeal and
           Analgesic Activities of Leaves of Triumfetta pilosa
    • Authors: Tanvir Ahmed, Amiyo Bala, Jalal Uddin, Zubair Khalid Labu
      Pages: 226 - 232
      Abstract: The aim of the research has been focused on the phytochemical investigation of the plants which have ethno-botanical and folkloric importance for drug discovery. The widespread availability and folkloric use of Triumfetta pilosa leaves led us to determine the pharmacological potential of the plant through in vitro and in vivo experiments. The crude ethanolic extract (EE) of T. pilosa leaves were partitioned successively using solvent of different polarities. Then these fractions were subjected to qualitative and quantitative phytochemical screening by standard procedures. The extract of T. pilosa and its fractions were evaluated for their possible thrombolytic, membrane stabilizing, antidiarrhoeal and analgesic activities by using standard drugs streptokinase, acetyl salicylic acid, loperamide and diclofenac-Na, respectively. In the study for thrombolytic activity, among all partitionates, the ethyl acetate soluble fraction (ESF) showed the highest percent of clot lysis (58.67%) as compared to standard streptokinase (69.23%) and water (3.77%). Also, in case of membrane stabilizing activity, ESF significantly inhibited the haemolysis of human erythrocyte membrane both induced by hypotonic solution (65.33 ± 0.50%) and heat (56.22 ± 0.69%), as compared to standard acetyl salicylic acid (ASA) (71.12 ± 26%) and (75.92 ± 0.29%), respectively. In the antidiarrheal assay, the crude ethanolic extract inhibited the mean number of defecation by 45.71% and 63.18% at 200 and 400-mg/kg body weight, respectively. During assay for central and peripheral analgesic activity at dose of 400-mg/kg, the extract showed reaction times of 5.11 (p < 0.001) and 1.96 (p < 0.001) min in the tail-flick and tail-immersion models, while the normal and reference groups exhibited reaction times of 11.66, 1.46; (p < 0.001) and 4.91, 1.16; (p < 0.001) in the tail flick and tail immersion method, respectively. At 400 mg/kg, the extract showed 49.22% inhibition of acetic acid induced writhing in mice model.Bangladesh Pharmaceutical Journal 19(2): 226-232, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Chemical and Biological Investigations of Leaves of Abroma augusta Linn.
    • Authors: SM Ashikur Rahman, Muhammed Mahfuzur Rahman, Md Aslam Hossain, Mohammad A Rashid
      Pages: 233 - 236
      Abstract: Abstract not availableBangladesh Pharmaceutical Journal 19(2): 233-236, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Constituents of Erythrina - a Potential Source of Secondary Metabolities:
           A Review
    • Authors: Mohammad Musarraf Hussain, Md Tariqul Haque Tuhin, Fahima Akter, Mohammad A Rashid
      Pages: 237 - 253
      Abstract: The genus Erythrina is a potential source of chemical constituents, many of which medicinal properties. Although some reviews on chemical constituents of particular Erythrina species could be found, no detailed review covering the chemistry of different Erythrina species has been reported to the best of my knowledge. Therefore, the aim of this review was to compile the phytoconstituents reported from various species of Erythrina. A total of 155 secondary metabolites have been published from 15 species of Erythrina. Among them E. subumbrans and E. variegata consist of the highest number of chemical constituents.Bangladesh Pharmaceutical Journal 19(2): 237-253, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
  • Recent Health Issues Vol 19(2)
    • Authors: Md Akbar Hossain
      Pages: 254 - 257
      Abstract: Abstract not availableBangladesh Pharmaceutical Journal 19(2): 254-257, 2016
      PubDate: 2016-08-12
      Issue No: Vol. 19, No. 2 (2016)
       
 
 
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