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Publisher: Bangladesh Journals Online   (Total: 103 journals)

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Anwer Khan Modern Medical College J.     Open Access   (Followers: 1)
Bangabandhu Sheikh Mujib Medical University J.     Open Access  
Bangladesh Critical Care J.     Open Access  
Bangladesh J. of Agricultural Research     Open Access   (Followers: 3)
Bangladesh J. of Anatomy     Open Access  
Bangladesh J. of Animal Science     Open Access  
Bangladesh J. of Bioethics     Open Access   (Followers: 2)
Bangladesh J. of Botany     Open Access   (SJR: 0.226, h-index: 9)
Bangladesh J. of Child Health     Open Access  
Bangladesh J. of Dental Research & Education     Open Access   (Followers: 2)
Bangladesh J. of Endosurgery     Open Access   (Followers: 2)
Bangladesh J. of Library and Information Science     Open Access   (Followers: 33)
Bangladesh J. of Medical Biochemistry     Open Access   (Followers: 2)
Bangladesh J. of Medical Education     Open Access   (Followers: 1)
Bangladesh J. of Medical Microbiology     Open Access  
Bangladesh J. of Medical Physics     Open Access  
Bangladesh J. of Medical Science     Open Access   (SJR: 0.21, h-index: 3)
Bangladesh J. of Medicine     Open Access   (Followers: 1)
Bangladesh J. of Nuclear Medicine     Open Access  
Bangladesh J. of Nutrition     Open Access   (Followers: 4)
Bangladesh J. of Orthodontics and Dentofacial Orthopedics     Open Access  
Bangladesh J. of Otorhinolaryngology     Open Access  
Bangladesh J. of Pharmacology     Open Access   (SJR: 0.243, h-index: 10)
Bangladesh J. of Physiology and Pharmacology     Open Access  
Bangladesh J. of Plant Breeding and Genetics     Open Access   (Followers: 2)
Bangladesh J. of Plant Taxonomy     Open Access   (Followers: 1, SJR: 0.248, h-index: 6)
Bangladesh J. of Plastic Surgery     Open Access  
Bangladesh J. of Scientific and Industrial Research     Open Access  
Bangladesh J. of Scientific Research     Open Access   (Followers: 1)
Bangladesh J. of Urology     Open Access   (Followers: 2)
Bangladesh J. of Veterinary Medicine     Open Access   (Followers: 1)
Bangladesh Medical J.     Open Access  
Bangladesh Medical J. Khulna     Open Access  
Bangladesh Medical Research Council Bulletin     Open Access   (SJR: 0.295, h-index: 13)
Bangladesh Pharmaceutical J.     Full-text available via subscription   (Followers: 2)
Bangladesh Rice J.     Open Access  
Bangladesh Veterinarian     Open Access   (Followers: 1)
BIRDEM Medical J.     Open Access   (Followers: 2)
Cardiovascular J.     Open Access   (Followers: 2)
Chattagram Maa-O-Shishu Hospital Medical College J.     Open Access  
Chemical Engineering Research Bulletin     Open Access   (Followers: 1, SJR: 0.207, h-index: 2)
Chittagong University J. of Biological Sciences     Open Access  
City Dental College J.     Open Access   (Followers: 2)
Community Based Medical J.     Open Access  
Delta Medical College J.     Open Access   (Followers: 2)
Dhaka University J. of Biological Sciences     Open Access  
Dhaka University J. of Pharmaceutical Sciences     Open Access   (Followers: 2, SJR: 0.171, h-index: 6)
Dhaka University J. of Science     Open Access  
Eastern Librarian     Open Access   (Followers: 13)
Faridpur Medical College J.     Open Access   (Followers: 1)
GANIT : J. of Bangladesh Mathematical Society     Open Access  
Ibrahim Cardiac Medical J.     Open Access  
Ibrahim Medical College J.     Open Access  
Intl. Current Pharmaceutical J.     Open Access   (Followers: 3)
Intl. J. of Agricultural Research, Innovation and Technology     Open Access   (Followers: 1)
Intl. J. of Natural Sciences     Open Access   (Followers: 1)
Intl. J. of Pharmaceutical and Life Sciences     Open Access   (Followers: 5)
J. of Advanced Veterinary and Animal Research     Open Access   (Followers: 6)
J. of Armed Forces Medical College, Bangladesh     Open Access  
J. of Bangladesh Society of Physiologist     Open Access  
J. of Bio-Science     Open Access   (Followers: 1, SJR: 0.103, h-index: 2)
J. of Business and Technology (Dhaka)     Open Access  
J. of Chemical Engineering     Open Access   (Followers: 4)
J. of Current and Advance Medical Research     Open Access  
J. of Dhaka Medical College     Open Access  
J. of Dhaka National Medical College & Hospital     Open Access  
J. of Enam Medical College     Open Access  
J. of Environmental Science and Natural Resources     Open Access   (Followers: 3)
J. of Life and Earth Science     Open Access  
J. of Mechanical Engineering     Open Access   (Followers: 4, SJR: 0.11, h-index: 1)
J. of Medicine     Open Access   (Followers: 1, SJR: 0.111, h-index: 22)
J. of National Institute of Neurosciences Bangladesh     Open Access  
J. of Naval Architecture and Marine Engineering     Open Access  
J. of Paediatric Surgeons of Bangladesh     Open Access  
J. of Science Foundation     Open Access   (Followers: 2)
J. of Scientific Research     Open Access   (Followers: 1)
J. of Shaheed Suhrawardy Medical College     Open Access  
J. of Surgical Sciences     Open Access  
J. of the Asiatic Society of Bangladesh, Science     Open Access  
J. of the Bangladesh Agricultural University     Open Access  
J. of the Bangladesh Association of Young Researchers     Open Access  
J. of the Bangladesh Chemical Society     Open Access  
J. of the Bangladesh Society of Anaesthesiologists     Open Access  
Jahangirnagar University Environmental Bulletin     Open Access  
KYAMC J.     Open Access   (Followers: 1)
Medicine Today     Open Access   (SJR: 0.188, h-index: 5)
Mediscope     Open Access  
Microbes and Health     Open Access   (Followers: 2)
Northern Intl. Medical College J.     Open Access  
Northern University J. of Law     Open Access  
Philosophy and Progress     Open Access  
Progressive Agriculture     Open Access   (Followers: 1)
Pulse : Medical J. of Apollo Hospitals Dhaka     Open Access  
Rajshahi University J. of Life & Earth and Agricultural Sciences     Open Access   (Followers: 1)
Research in Agriculture, Livestock and Fisheries     Open Access  
SAARC J. of Agriculture     Open Access  
South East Asia J. of Public Health     Open Access   (Followers: 3)
Stamford J. of English     Open Access   (Followers: 1)
Stamford J. of Microbiology     Open Access  
The Agriculturists     Open Access  

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Journal Cover   Bangladesh Pharmaceutical Journal
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   Full-text available via subscription Subscription journal
   ISSN (Print) 0301-4606
   Published by Bangladesh Journals Online Homepage  [103 journals]
  • Analgesic and Neuropharmacological Activities of Methanol Extract from the
           Leaf of Nicotiana plumbaginifolia Viv.
    • Authors: Mehedi Shahriar, Sadia Afreen Chowdhury, Mohammad Zafar Imam, Bidyut Kanti Datta
      Pages: 85 - 89
      Abstract: The aim of study was to evaluate the analgesic and neuropharmacological activities of the leaf of Nicotiana plumbaginifolia. The central analgesic activity of the methanolic extract was evaluated in Swiss Albino mice by using tail immersion, hot plate and acetic acid-induced writhing tests at 100, 200 and 400 mg/kg body weight. These tests showed significant analgesic activity of the extract compared to the standard drug, diclofenac-Na (1 mg/kg b.w.). The neuropharmacological activities were evaluated using hole cross, open field, light/dark box and elevated plus maze stage tests in mice model at 100, 200 and 400 mg/kg body weight. The results of neuropharmacological assays demonstrated potential CNS depressant activity of the extract when compared to the standard drug, diazepam (1 mg/kg b.w.)Bangladesh Pharmaceutical Journal 18(2): 85-89, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • In Silico Molecular Docking Studies of Lichen Metabolites against
           Cyclooxygenase-2 Enzyme
    • Authors: Mohammad Firoz Khan, Sabreena Aleem Nabila, Ridwan Bin Rashid, Mohammad Sharifur Rahman, Abu Asad Chowdhury, Mohammad Abdur Rashid
      Pages: 90 - 96
      Abstract: Cyclooxygenase-2 (COX-2) is an inducible enzyme that causes inflammation. COX-2 inhibitors are clinically effective anti-inflammatory agents with less gastrointestinal and renal toxicities. However, they lack anti-thrombotic activity and hence lead to increased incidences of adverse cardiovascular thrombotic events, including myocardial infarction. Therefore, there is still need to develop COX-2 inhibitors with better therapeutic effects and tolerability. The aim of the present study is to explore the anti-inflammatory activity of five lichen metabolites by conducting virtual screenings. In this regard, molecular docking simulations were carried out for the lichen metabolites namely atranorin, diffractic acid, lecanoric acid, salazinic acid and usnic acid with human COX-2 enzyme and the docked results were compared with the standard reference ligands (Celecoxib and Rofecoxib). Among all the docked ligands, the lecanoric acid demonstrated best binding affinity -9.83 kcal/mol followed by atranorin (-8.7 kcal/mol) and diffractic acid (-8.6 kcal/mol) which are comparable to the reference ligands celecoxib (-12.3 kcal/mol) and rofecoxib (-11.2 kcal/mol). The salazinic acid and usnic acid has shown binding affinity of -7.9 kcal/mol and -4.7 kcal/mol, respectively. Moreover, all the ligands except atranorin and diffractic acid satisfied Lipinski’s rule of 5. From the docking results it was revealed that the lichen metabolites might have inhibitory activity against COX-2 enzyme, and are expected to be useful in conducting in vivo anti-inflammatory screenings on animal model which may lead to the development of more effective and potent new chemical entities with anti-inflammatory properties.Bangladesh Pharmaceutical Journal 18(2): 90-96, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • Preparation and Evaluation of Metronidazole Benzoate Periodontal Patches
    • Authors: Farhana Tasneem, Marzia Alam, Md Saiful Islam Pathan
      Pages: 97 - 102
      Abstract: Periodontitis is a serious gum disease that damages the soft tissue and destroys the bone that supports the teeth. According to WHO, globally 15–20% of middle-aged (35-44 years) adults, suffer from severe periodontal (gum) diseases. Metronidazole benzoate is an antibacterial agent prescribed against different diseases including, periodontitis and several other protozoal infestations. The aim of this experiment was to formulate intrapocket periodontal patches of metronidazole benzoate to provide site specific therapeutic activity with very small loading dose. Nine (F1 to F9) formulations of metronidazole benzoate were prepared by solvent casting method using ethyl cellulose and Eudragit RLPO as polymers, dibutyl phthalate as plasticizer and alcohol and chloroform as solvent system. Various physicochemical evaluations including FTIR, Trinocular Microscopic images, folding endurance, surface pH and content uniformity were determined. All the batches revealed content uniformity between 94.0% to 98.0%. It was observed that the thickness and weight of the films were directly proportional to the total solid content of the film. F1 showed the lowest thickness and weight (232.5 μm and 35.45 mg respectively) and F9 displayed the highest (864.7 μm and 85.23 mg respectively). Folding endurance was directly proportional to the content of plasticizer. Formulation F3 was considered as the best formulation based on its transparent appearance, folding endurance (>200 times), surface pH (6-7) and 97.5% content uniformity.Bangladesh Pharmaceutical Journal 18(2): 97-102, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • Evaluation of Antibacterial, Antifunfgal and Cytotoxic Potentials of Crude
           Metabolite of ANAM-39, a Marine Bacterium Isolated from Sundarbans,
           Bangladesh
    • Authors: Ashish Kumar Sarker, Md Anwarul Haque, Urmi Saha, Md Ajijur Rahman, Md Anwar Ul Islam
      Pages: 103 - 109
      Abstract: The present study was undertaken to screen the antimicrobial, antifungal and cytotoxic potentials of crude metabolite of a marine bacterium isolated from a soil sample collected from Sundarbans, Bangladesh. Primary and secondary screenings for antimicrobial activity were conducted by cross streak and agar well diffusion method, respectively. The antifungal potency of the crude extract was also tested by agar well-diffusion method. The brine shrimp lethality test was conducted to determine the cytotoxic nature of crude metabolites, which showed that the degree of lethality of metabolite was directly proportional to the concentration (LC50 30.19 μg/ml). Further studies are needed to isolate and characterize the active principles present in the crude metabolite and determine their biological activity. The results of this investigation suggested that the soils of Sundarbans are rich sources of microorganisms with potent biological activities and systematic screening programs need to be conducted to explore the presence of pharmacologically active marine bacterial metabolites.Bangladesh Pharmaceutical Journal 18(2): 103-109, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • Chemical Modification of Chitosan in order to Inverse Swelling Behavior:
           Comparison between Crosslinking, Michael Addition and Graft
           Copolymerization Reactions
    • Authors: Solmaz Zakhireh, Mehrdad Mahkam, Yousef Toomari, Saeed Jafarirad
      Pages: 110 - 117
      Abstract: In the present work, three methods were used to inverse chitosan swelling behavior including, conjugation of p-amino benzoic acid (PABA) on cross-linked chitosan in different condition, Michael addition reaction of acrylic acid (AA) on chitosan and finally graft copolymerization of methacrylic acid (MMA) on chitosan. We couldn’t inverse chitosan swelling behavior by the Michael addition reaction of acrylic acid, but conjugation of PABA on cross-linked chitosan inversed the chitosan swelling behavior. In addition, the graft copolymerization of MMA on chitosan was also successful. In general, the third method, among the above-mentioned modifications provided the best results.Bangladesh Pharmaceutical Journal 18(2): 110-117, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • In vitro and in vivo Antiamoebic Potential of Actinopyga lecanora (Jaeger)
    • Authors: Vijai Lakshmi, Sheela Ghosal
      Pages: 118 - 120
      Abstract: Human amoebiasis, due to Entamoeba histolytica infection, is mainly associated with morbidity thus affecting the quality of life and pace of development in the countries with warm climatic conditions. So far, the available drugs provide only symptomatic relief and they are not devoid of side effects. This leads to obtain novel molecules from natural sources having antiamoebic activity. The methanol extract of Actinopyga lecanora (Jaeger) displayed antiamoebic activity. It showed MIC 125 μg/ml in our in-vitro studies, but when it was tested in rats, it revealed 88% inhibition of trophozoites at the dose of 900 mg/kg body weight against Entamoeba histolytica. Further work is in progress for the isolation and characterization of active molecules.Bangladesh Pharmaceutical Journal 18(2): 118-120, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • Antibiotic Sensitivity of Staphylococcus aureus and Staphylococcus
           epidermidis Isolated from Acne Patients
    • Authors: Ashfia Fatima Khan, Humayera Kabir Hana, Jakaria Sheak, Kohinur Begum
      Pages: 121 - 125
      Abstract: In this study, twenty five samples were collected from acne, ranging from 20 to 25 years old patients. The specimens were cultured on trypticase soy agar (TSA) plate. 25 suspected single colonies were isolated using mannitol salt agar. Isolates were identified by short biochemical tests such as catalase, coagulase, oxidase and Gram staining test. Five Staphylococcus aureus and eleven Staphylococcus epidermidis strains were identified. Antibiotic sensitivity of all strains was tested according to the Kirby-Bauer method using commercially available gentamicin, erythromycin, azithromycin, oxacillin, clindamycin and rifampicin discs. 100% of the isolates were sensitive to gentamicin and rifampicin. On the other hand, 93.75% isolates were sensitive to oxacillin, erythromycin and azithromycin and 81.25% isolates were sensitive to clindamicin. Minimum inhibitory concentration (MIC) of rifampicin and gentamicin was determined by test tube serial dilution method and it was found to be 4 μg/ml for both. Our results showed that both rifampicin and gentamicin are effective antibacterial agents for acne.Bangladesh Pharmaceutical Journal 18(2): 121-125, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • Bioactivities of Chukrasia tabularis (A. Juss.)
    • Authors: Sharmin Aktar, Marzia Bilkiss, Faiza Tahia, Md Al Amin Sikder, Ridwan B Rashid, Mohammad A Rashid
      Pages: 126 - 131
      Abstract: The methanol extracts of bark and leaves of Chukrasia tabularis and their organic and aqueous soluble materials were subjected to screenings for antioxidant, cytotoxic, thrombolytic, membrane stabilizing, antimicrobial, analgesic and antidiarrhoel activities. In the DPPH free radical scavenging assay, the methanolic extract of bark of C. tabularis and the aqueous soluble fraction of methanol extract of leaves of C. tabularis revealed the highest free radical scavenging activity with IC50 values of 2.95 μg/ml and 5.31 μg/ml, respectively. The pet ether soluble fraction of methanolic extract of leaves and bark of C. tabularis displayed the highest cytotoxic potential having LC50 values 0.0167 μg/ml and 3.89 μg/ml, as compared to standard vincristine sulphate (LC50 value of 0.45 μg/ml). During thrombolytic assay, the aqueous soluble fraction of leaves and carbon tetrachloride soluble fraction of bark of C. tabularis showed 34.04% and 56.37% clot lysis, respectively. In the membrane stabilizing assay, the carbontetrachloride and aqueous soluble materials of methanol extract of leaf inhibited 21.03% and 49.68% hypotonic solution- and heat-induced haemolysis of RBC, respectively. The crude extract of leaves of C. tabularis exhibited mild antibacterial activity, while that of leaves and bark revealed significant central analgesic activity at 400 mg/kg body weight. The crude extracts demonstrated significant peripheral analgesic activity at 200- and 400- mg/kg body weight. On the other hand, the crude extract of leaves of C. tabularis revealed significant antidiarrhoel activity.Bangladesh Pharmaceutical Journal 18(2): 126-131, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • Development and Evaluation of Salbutamol Sulphate Loaded Ethyl Cellulose
           Microcapsules using Emulsion Solvent Evaporation Technique
    • Authors: Md Shamsul Alam, Jakir Ahmed Chowdhury, Sams Mohammad Anowar Sadat, Md Selim Reza
      Pages: 132 - 136
      Abstract: Ethyl cellulose (EC) microcapsules containing Salbutamol sulphate (SS) were prepared through emulsion-solvent evaporation technique. Microcapsules were compressed and in-vitro release profiles were studied from both microcapsules and their compressed matrix tablets. Different amounts of drug were added in order to obtain various drugs to polymer ratios and it was found that the size of microcapsules reduced with the increase in core loading. In the preparation of formulations, Tween 80 was used as an emulsifying or dispersing agent and light liquid paraffin (LLP) was used as oil phase. The in-vitro release of EC microcapsules was studied in distilled water at 37º ± 0.5°C. A biphasic release behavior of SS from microcapsules was observed. In case of microcapsules, an immediate release was observed but for their compressed tablet form, initially a burst effect and then slow release were observed which was extended for 8 hours. In order to further investigate the type of drug release mechanism, the dissolution data were plotted according to the different kinetic models. In-vitro dissolution studies showed that zero-order and square-root of time (Higuchi model) release characteristics were exhibited.Bangladesh Pharmaceutical Journal 18(2): 132-136, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • A Survey of the Role of Community Pharmacists in Dhaka city, Bangladesh
    • Authors: Abdur Rakib, Md Shahid Sarwar, Shaheda Zannah, Sayema Khanum, Mamunur Rashid
      Pages: 137 - 141
      Abstract: Community pharmacists play a vital role in improving medication safety and better healthcare facility to the community. Unfortunately, the field of community pharmacy in Bangladesh is still to be developed and there is scarcity of data regarding current role of community pharmacists in Bangladesh. The present study was conducted to find out the role of community pharmacists in Bangladesh. For the study purpose, we visited 42 retail pharmacies in Banani, Khilkhet and Uttra areas of Dhaka city and interviewed the community pharmacists working there. We found that there were total 50 community pharmacists in 42 retail pharmacy and also observed that most of the pharmacists (64%) worked alone. Interestingly, we didn’t find a single A-grade pharmacist working as community pharmacist. B-grade pharmacists who completed a 3 year diploma in pharmacy were only 4 in number and 92% of them were C-grade pharmacists with 3-4 months training. The average age of the participants was 29.6 ± 1.2 years. The average length of service for the community pharmacists was 7.6 ± 1.3 years. The top issues that patients consulted with the pharmacists were on medication use (76%), which physician they should visit (54%) and therapy (26%). There was not a significant effect of work experience of community pharmacists on their attitudes toward community-based clinical services. In this study, we observed that 95% community pharmacies provide blood pressure measurement facility, 90% provide diabetes screening, 76% provide dressing services, and only 47% provide nebulization. No community pharmacist was found to be involved with adverse drug reaction reporting. In conclusion, we recommend that the government and the pharmacy regulatory authority should take sufficient initiatives to develop the community pharmacy sector in Bangladesh for the welfare of mankind.Bangladesh Pharmaceutical Journal 18(2): 137-141, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • Antitumor, Analgesic and Anti-inflammatory Activities of Glochidion
           multiloculare (Rottler ex Willd) Voigt
    • Authors: Selina Kabir, Ronok Zahan, Abdullah Mohammad Sarwaruddin Chowdhury, Mohammad Rashedul Haque, Mohammad Abdur Rashid
      Pages: 142 - 148
      Abstract: The antitumor, analgesic and anti-inflammatory activities of the methanol extract (MEGM) of Glochidion multiloculare and its petroleum ether (PEFGM), carbon tetrachloride (CTFGM) and chloroform (CHFGM) soluble fractions were investigated. The antitumor activity of the extract/fractions was determined against Ehrlich’s ascites carcinoma (EAC) in mice at 20 mg/kg body weight intraperitoneally. Increase of survival time by 24 ± 0.12, 26 ± 0.40, 21 ± 0.12 and 27 ± 0.42 days was observed by the MEGM, PEFGM, CTFGM and CHFGM treated tumor bearing mice compared to the control group (20 ± 0.12 days). Hematological studies revealed that heamoglobin (Hb) content was decreased in EAC treated mice whereas restoration to normal levels was observed in extract/fractions treated animals. Significant decrease in RBC and increase in WBC counts were observed in extract/fractions treated animals when compared to EAC affected animals. Both extract and fractions at the dose of 100 mg/kg b.w. significantly increased the pain threshold in tail immersion method and reduced the writhing caused by acetic acid induced method. The MEGM, PEFGM, CTFGM and CHFGM showed anti-inflammatory activities at 100 mg/kg b.w. This is the first report of antitumor, analgesic and anti-inflammatory potential of G. multiloculare.Bangladesh Pharmaceutical Journal 18(2): 142-148, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • Screening and Characterization of Bacteriocin-Like Inhibitory Substances
           Produced by Bangladeshi Strains of Bacillus thuringiensis
    • Authors: Md Nahidul Islam, Nahinur Rahman Akhand, Arafat Al Mamun, Asaduzzaman Shishir, Marufa Zerin Aktar, Shakila Nargis Khan, Md Mozammel Hoq, Mohammad Shahnoor Hossain
      Pages: 149 - 156
      Abstract: Bacteriocins are ribosomally synthesized antibacterial peptides which have the potential to be used as natural food preservatives as well as alternative to antibiotics. Here, we report the production of bacteriocin-like inhibitory substances (BLIS) from the indigenous strains of Bacillus thuringiensis. Deferred antagonism bacteriocin assay and agar well diffusion methods suggested that several of the tested strains have high levels of bacteriocin-like activity against the common food-borne pathogens, Listeria monocytogenes, Staphylococcus aureus and Bacillus cereus. These bacteriocins are generally produced at the mid-logarithmic phase of growth with optimum temperature of 37 ºC, pH-7.0 and 24 h of incubation. Heat stability assay demonstrated that the bacteriocins produced from the strains are highly heat stable and can retain activity up to 100 ºC. Our study suggests that these bacteriocins may be potential candidates for use as biodegradable natural food preservatives and alternative antimicrobial agents to solve the increasing trends of problems of antibiotic resistance.Bangladesh Pharmaceutical Journal 18(2): 149-156, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • Formulation and in vitro Evaluation of Glimepiride Sustained Release
           Tablets: Comparison with Immediate Release Tablets
    • Authors: Samira Karim, Mohiuddin Ahmed Bhuiyan, Md Sohel Rana
      Pages: 157 - 162
      Abstract: This work aims at the design of a sustained release formulation of glimepiride which is currently available in the treatment of type 2 diabetes mellitus and to investigate the effect of polymers on the release profile of glimepiride. Glimepiride sustained release tablets were prepared by direct compression method using different ratios of various release retarding polymers such as carbopol, ethyl cellulose, methocel K4 MCR, methocel K15 MCR, methocel K100 MCR and xanthum gum. These formulations were also compared with glimepiride immediate release tablets. The prepared tablets were subjected to various physical parameter tests including weight variation, friability, hardness, thickness, diameter, etc. In vitro dissolution studies of the formulations were done at pH 6.8 in phosphate buffer using USP apparatus 2 (paddle method) at 50 rpm. The percent releases of all the formulations (30) were 73.11%- 98.76% after 8 hours. The release pattern followed zero order kinetics and the release of the drug was hindered by the polymers used in the study. On the other hand, 100% drug was released within 1 hour from the immediate release tablet of glimepiride. The study reveals that the polymers used have the capacity to retard the release of the drug from the sustained release tablets and the more is the amount of the polymer in the formulation the less is the release of drug showing more retardation of drug release.Bangladesh Pharmaceutical Journal 18(2): 157-162, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • Development and Validation of a UV-Spectrophotometric Method for
           Determination of Vildagliptin and Linagliptin in Bulk and Pharmaceutical
           Dosage Forms
    • Authors: Sujan Banik, Palash Karmakar, Md Anowar Hossain Miah
      Pages: 163 - 168
      Abstract: The present study was undertaken to develop a spectrophotometric method for determination of vildagliptin and Linagliptin in pharmaceutical dosage forms. This paper describes a simple, rapid, accurate and precise UVspectrophotometric method for the assay of vildagliptin and linagliptin in bulk and marketed tablet dosage forms. The validation of the developed method was carried out according to ICH guidelines with respect to linearity, precision, accuracy, specificity, limit of detection and limit of quantification. Calibration curves were obtained in the concentration range of 8-32 μg/ml for vildagliptin and 5-25 μg/ml for linagliptin with good correlation coefficients (r=0.999). The precisions of the new method for both drugs were less than the maximum allowable limit (%RSD < 2.0) specified by the USP, ICH and FDA. Therefore, the method was found to be an accurate, reproducible and sensitive for analysis of vildagliptin and linagliptin in pharmaceutical dosage forms.Bangladesh Pharmaceutical Journal 18(2): 163-168, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • Anti-inflammatory and Antioxidant Activities of Cucumis sativus Leaves
    • Authors: Fatema Nasrin, Israt Jahan Bulbul, Fahima Aktar, Mohammad A Rashid
      Pages: 169 - 173
      Abstract: This study was carried out to evaluate the anti-inflammatory and antioxidant activities of Cucumis sativus Linn. (Family: Cucurbitaceae) leaves. The methanolic extract of C. sativus leaves (MCS) was investigated for antiinflammatory activities in Long Evans rat model at two different doses of 150 and 250 mg/kg body weight and the effects were compared with the standard, indomethacin (10 mg/kg body weight). It exhibited highest antiinflammatory activity at the dose 250 mg/kg. In the formalin test, the extract at both doses (150 and 250 mg/kg body weight) significantly prevented the increase in volume of paw edema (P<0.05 and P<0.001). In carrageenan-induced paw edema test the MCS significantly (P≤0.001) reduced inflammation by 57.35 % (150 mg/kg body weight) and 72.06% (250 mg/kg body weight) in comparison to the standard drug, indomethacin (79.41%) at the end of 5h. MCS was also screened for DPPH scavenging activity, total antioxidant capacity, reducing ability as well as total phenolics content to assess its antioxidant potential. Total phenolic content and total antioxidant capacity of MCS were found to be 262.31 mg/g equivalent of gallic acid and 267.2 mg/g equivalent of ascorbic acid, respectively. The IC50 of free radical scavenging of DPPH was 13.06 μg/ml while that of standard ascorbic acid was 13.17 μg/ml. The reducing power of MCS was found to be concentration dependent.Bangladesh Pharmaceutical Journal 18(2): 169-173, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • Survey on Antibiotic Practices in Chittagong City of Bangladesh
    • Authors: Mohammed Abu Sayeed, Nurunnobi Iqbal, Md Sekendar Ali, Md Masudur Rahman, Md Rafikul Islam, Md Jakaria
      Pages: 174 - 178
      Abstract: We aimed to determine the amount of antibiotic prescribed by physicians and also sold by pharmacies in Chittagong city of Bangladesh by using a cross sectional survey. Patients, physicians, pharmacies and prescriptions based study was conducted in May 01, 2012 to May 30, 2012. A total of 118 prescriptions were collected and 82 local pharmacies were selected for data collection about daily sales of antibiotics. It was evident that 69.49% of the prescriptions contained antibiotics. Azithromycin and cefixim were found to be the most preferred antibiotics in physician’s prescriptions survey. On the other hand, it was evident from the pharmacy survey (without prescription) selling rates of azithromycin and ciprofloxacin were more predominant. The diseases which were seen in the studies include cough, typhoid, diarrhea, nausea, chronic UTI, RTI, fever and rhinitis. The result of the present survey indicates that antibiotics are widely and inappropriately practiced without following standard guidelines. This is an alarming condition in the health sector of Bangladesh and therefore, the respective authority should take necessary steps to minimize the harmful effects of antibiotics.Bangladesh Pharmaceutical Journal 18(2): 174-178, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • Bioaccumulation and Toxicity of Iron Salt on Shingi Fish Heteropneustes
           fossils (Bloch) and its Possible Impacts on Human Health
    • Authors: Iftear Jahan, AKM Nur Alam Siddiki, M Niamul Naser, Md Abdus Salam
      Pages: 179 - 182
      Abstract: The freshwater Stinging catfish locally known as Shingi (Heteropneustes fossilis) is exposed to various concentrations of analytical grade FeSO4.7H2O. The LC50 values for Fe2+ were found to be 109, 68 and 45 mg/l at 24, 48 and 72 hrs, respectively indicating that the toxicity increased with time. Gills appear to be the first target organ for iron toxicity followed by the liver and muscle. Moisture contents in fish tissue increased due to release of the toxicant by biological way. Protein and lipid contents are decreased and ash content is increased with the increase of exposure time. In contrast, iron is relatively nontoxic to Shingi fish at low dose, but long time exposure has adverse effects in fish tissue. Thus, exposure to iron salt at toxic level resulted in accumulation of iron in fish tissue. Hence, the consumption of this type of contaminated fish might have detremental effect on human health. However, this needs extensive study to make any final conclusion.Bangladesh Pharmaceutical Journal 18(2): 179-182, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • Active Fractions from Asparagus racemosus Willd. with Thrombolytic,
           Membrane Stabilizing and Free Radical Scavenging Activities
    • Authors: Md Abdul Jalil, Mohammad Sharifur Rahman, SM Ashikur Rahman, Ridwan B Rashid, Mohammad A Rashid
      Pages: 183 - 186
      Abstract: Abstract not availableBangladesh Pharmaceutical Journal 18(2): 183-186, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • Recent Pharma News 18(2)
    • Authors: Md Akbar Hossain
      Pages: 187 - 191
      Abstract: Abstract not availableBangladesh Pharmaceutical Journal 18(2): 187-191, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
  • New drugs approval 18(2)
    • Authors: Md Akbar Hossain
      Pages: 192 - 194
      Abstract: Abstract not availableBangladesh Pharmaceutical Journal 18(2): 192-194, 2015
      PubDate: 2015-07-26
      Issue No: Vol. 18, No. 2 (2015)
       
 
 
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